Добірка наукової літератури з теми "Ribosomal leaky scanning"
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Статті в журналах з теми "Ribosomal leaky scanning":
Smirnova, Victoria V., Ekaterina D. Shestakova, Daria S. Nogina, Polina A. Mishchenko, Tatiana A. Prikazchikova, Timofei S. Zatsepin, Ivan V. Kulakovskiy, Ivan N. Shatsky, and Ilya M. Terenin. "Ribosomal leaky scanning through a translated uORF requires eIF4G2." Nucleic Acids Research 50, no. 2 (January 8, 2022): 1111–27. http://dx.doi.org/10.1093/nar/gkab1286.
Zhou, Weihui, and Weihong Song. "Leaky Scanning and Reinitiation Regulate BACE1 Gene Expression." Molecular and Cellular Biology 26, no. 9 (May 1, 2006): 3353–64. http://dx.doi.org/10.1128/mcb.26.9.3353-3364.2006.
Pisareva, Vera P., and Andrey V. Pisarev. "DHX29 reduces leaky scanning through an upstream AUG codon regardless of its nucleotide context." Nucleic Acids Research 44, no. 9 (April 11, 2016): 4252–65. http://dx.doi.org/10.1093/nar/gkw240.
Schneider, P. A., R. Kim, and W. I. Lipkin. "Evidence for translation of the Borna disease virus G protein by leaky ribosomal scanning and ribosomal reinitiation." Journal of virology 71, no. 7 (1997): 5614–19. http://dx.doi.org/10.1128/jvi.71.7.5614-5619.1997.
de Breyne, Sylvain, and Théophile Ohlmann. "Focus on Translation Initiation of the HIV-1 mRNAs." International Journal of Molecular Sciences 20, no. 1 (December 28, 2018): 101. http://dx.doi.org/10.3390/ijms20010101.
Liu, Q., and G. Hobom. "Evidence for translation of VP3 of avian polyomavirus BFDV by leaky ribosomal scanning." Archives of Virology 145, no. 2 (February 15, 2000): 407–16. http://dx.doi.org/10.1007/s007050050032.
Smith, E. "Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo." Nucleic Acids Research 33, no. 4 (February 23, 2005): 1298–308. http://dx.doi.org/10.1093/nar/gki248.
Ferreira, Joshua P., William L. Noderer, Alexander J. Diaz de Arce, and Clifford L. Wang. "Engineering ribosomal leaky scanning and upstream open reading frames for precise control of protein translation." Bioengineered 5, no. 3 (January 14, 2014): 186–92. http://dx.doi.org/10.4161/bioe.27607.
Stacey, Simon N., Deborah Jordan, Andrew J. K. Williamson, Michael Brown, Joanna H. Coote, and John R. Arrand. "Leaky Scanning Is the Predominant Mechanism for Translation of Human Papillomavirus Type 16 E7 Oncoprotein from E6/E7 Bicistronic mRNA." Journal of Virology 74, no. 16 (August 15, 2000): 7284–97. http://dx.doi.org/10.1128/jvi.74.16.7284-7297.2000.
Latorre, Patrizia, Daniel Kolakofsky, and Joseph Curran. "Sendai Virus Y Proteins Are Initiated by a Ribosomal Shunt." Molecular and Cellular Biology 18, no. 9 (September 1, 1998): 5021–31. http://dx.doi.org/10.1128/mcb.18.9.5021.
Дисертації з теми "Ribosomal leaky scanning":
Chan, Mine Emeric. "La protéine C du virus Nipah : mécanismes d'expression et implications virales." Electronic Thesis or Diss., Lyon, École normale supérieure, 2024. http://www.theses.fr/2024ENSL0002.
The Nipah virus (NiV) is a non-segmented negative-sense RNA virus belonging to the Paramyxoviridae family. The NiV genome contains only 6 genes but codes for 9 different proteins. Several proteins are expressed from the P gene, including the phosphoprotein P and the C protein. The C protein, expressed from an alternative open reading frame through a ribosomal leaky scanning mechanism, plays a yet poorly understood role in viral replication. To study its function, numerous studies have been conducted on a recombinant NiV deficient in C expression (rNiV CKO), where the initiator codons of C have been removed, without altering other reading frames of the proteins derived from the P gene. We hypothesized that the absence of the C translation initiation site does not prevent the ribosomal leaky scanning mechanism but that these mutations lead to a disorganization of the expression of proteins derived from the P gene. We confirmed this hypothesis by demonstrating that rNiV CKO expresses truncated forms of the C and P proteins, named respectively C’ and P’. Furthermore, our comparative evaluation of rNiV CKO and wild-type NiV (WT) revealed that rNiV CKO produces less infectious viral particles, which directed our research towards the impact of C, C', and P' proteins on viral replication. We developed a NiV minigenome system and studied the effect of these proteins on the viral polymerase activity in this system. C and C' showed negative regulation of polymerase activity, with a more pronounced regulation by C'. Additionally, we observed differences in cellular localization between C and C', with the latter localizing in inclusion bodies in the presence of viral proteins involved in RNA synthesis. Regarding the P' protein, although it lost its primary function of binding to monomeric nucleoproteins, no dominant negative effect was observed on NiV polymerase activity. Moreover, a mixture of P’ and P lacking their C-terminal Px domain can effectively substitute for wild-type P in the minigenome system, providing new insights into the NiV replication mechanism. In conclusion, our results collectively suggest that the organization of P gene expression is complex, likely due to two interdependent requirements: the synthesis of C depends on weak initiation of P translation, and the translation initiation of C protein is necessary to prevent potentially aberrant expression of truncated forms of C and P
Частини книг з теми "Ribosomal leaky scanning":
Stepicheva, N. A., P. Shang, S. Ghosh, V. Koontz, S. Hose, J. S. Zigler, and D. Sinha. "Multifunctional Proteins and Alternative Translation: Functional Diversification of BetaA3/A1-Crystallin Via Leaky Ribosomal Scanning." In Essentials in Ophthalmology, 131–43. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-4436-1_9.