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Статті в журналах з теми "Renal histology"

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Автор: Grafiati

Опубліковано: 22 червня 2024

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1

Spaliviero, Massimiliano, Kelly Lynn Stratton, Timothy F. Donahue, Banumathy Gowrishankar, Charles Ma, Jeremy C. Durack, Stephen Barnett Solomon, Jane Houldsworth, and Jonathan A. Coleman. "Fluorescence in situ hybridization (FISH) and array-comparative genomic hybridization (a-CGH) from percutaneous needle biopsy compared to renal mass histology." Journal of Clinical Oncology 31, no. 6_suppl (February 20, 2013): 471. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.471.

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471 Background: Image-guided percutaneous needle biopsies are increasingly utilized for the diagnosis of renal tumors. Histologic diagnosis of renal mass subtypes, including malignant clear cell (ccRCC), papillary (pRCC), chromophobe (chrRCC) renal cell carcinoma, and benign oncocytomas (OC) can be challenging due to the low cellularity and damaged architecture of needle biopsy specimens. However, each subtype exhibits unique genetic aberrations that can assist in histologic classification and potentially assist in guiding management decisions. We report our initial experience correlating renal mass histology to subtype-associated genomic alterations detected by FISH and a-CGH of percutaneous needle biopsy specimens. Methods: In an ongoing IRB-approved blinded study, 17 samples obtained from 15 patients with known renal masses were submitted to FISH (FReCaD) and targeted a-CGH (UroGenRA-Kidney). Specimens were classified using a subtype classification decision tree algorithm based on the presence/absence of genomic abnormalities. The results were compared to biopsy histology or surgical specimen when available. Results: Histology revealed ccRCC in 6 patients, pRCC in 4, OC in 2, Angiomyolipoma in 1, and unclassified type RCC in 2. In 6 of 9 cases FISH achieved a diagnosis, which correlated with histology in 4. FISH incorrectly classified as ccRCC two cases with pRCC on histology. A-CGH was diagnostic in 14 of 15 cases and correlated with histology in 13. In one case, a-CGH showed a genomic profile not consistent with ccRCC, pRCC, chrRCC, or OC according to the algorithm. Conclusions: The addition of genetic tumor tissue studies to complement histology from biopsy tissues may supplement or improve the accuracy of classification and biological characterization of renal tumor biopsies and influence treatment planning. In our initial experience, a-CGH showed better correlation with histology in subtype classification of malignant and benign renal masses than FISH. Prospective testing will be required to validate these results.

2

Zajjari, Yassir, Taoufiq Aatif, Kawtar Hassani, Sanaa Benbria, and Driss El Kabbaj. "Renal histology in diabetic patients." Saudi Journal of Medicine and Medical Sciences 7, no. 1 (2019): 22. http://dx.doi.org/10.4103/sjmms.sjmms_76_18.

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3

d'Ardenne, A. J., M. S. Dunnill, J. F. Thompson, D. McWhinnie, R. F. Wood, and P. J. Morris. "Cyclosporin and renal graft histology." Journal of Clinical Pathology 39, no. 2 (February 1, 1986): 145–51. http://dx.doi.org/10.1136/jcp.39.2.145.

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4

Serón, Daniel, Dolores Burgos, and Ángel Alonso. "Histology and proteinuria after renal transplantation." Transplantation Reviews 26, no. 1 (January 2012): 20–26. http://dx.doi.org/10.1016/j.trre.2011.07.009.

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5

Malluche, H. H., M. C. Langub, and M. C. Monier-Faugere. "Pathogenesis and histology of renal osteodystrophy." Osteoporosis International 7, S3 (May 1997): 184–87. http://dx.doi.org/10.1007/bf03194369.

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6

Rice-Stitt, Travis, Aida Valencia-Guerrero, Kristine M. Cornejo, and Chin-Lee Wu. "Updates in Histologic Grading of Urologic Neoplasms." Archives of Pathology & Laboratory Medicine 144, no. 3 (March 1, 2020): 335–43. http://dx.doi.org/10.5858/arpa.2019-0551-ra.

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Context.— Tumor histology offers a composite view of the genetic, epigenetic, proteomic, and microenvironmental determinants of tumor biology. As a marker of tumor histology, histologic grading has persisted as a highly relevant factor in risk stratification and management of urologic neoplasms (ie, renal cell carcinoma, prostatic adenocarcinoma, and urothelial carcinoma). Ongoing research and consensus meetings have attempted to improve the accuracy, consistency, and biologic relevance of histologic grading, as well as provide guidance for many challenging scenarios. Objective.— To review the most recent updates to the grading system of urologic neoplasms, including those in the 2016 4th edition of the World Health Organization (WHO) Bluebook, with emphasis on issues encountered in routine practice. Data Sources.— Peer-reviewed publications and the 4th edition of the WHO Bluebook on the pathology and genetics of the urinary system and male genital organs. Conclusions.— This article summarizes the recently updated grading schemes for renal cell carcinoma, prostate adenocarcinomas, and bladder neoplasms of the genitourinary tract.

7

&NA;. "Ciclosporin withdrawal improves renal histology and function?" Inpharma Weekly &NA;, no. 1449 (August 2004): 12. http://dx.doi.org/10.2165/00128413-200414490-00028.

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8

LEE, BENJAMIN R., JEFFREY A. CADEDDU, GYONGYI MOLNAR-NADASDY, DEBBIE ENRIQUEZ, TIBOR NADASDY, LOUIS R. KAVOUSSI, and LLOYD E. RATNER. "Chronic Effect of Pneumoperitoneum on Renal Histology." Journal of Endourology 13, no. 4 (May 1999): 279–82. http://dx.doi.org/10.1089/end.1999.13.279.

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9

Van Loon, Elisabet, Evelyne Lerut, and Maarten Naesens. "The time dependency of renal allograft histology." Transplant International 30, no. 11 (September 28, 2017): 1081–91. http://dx.doi.org/10.1111/tri.13042.

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10

Gaber, L. W., L. W. Moore, L. Reed, W. Russell, R. Alloway, D. Hathaway, M. H. Shokouh-Amiri, and A. O. Gaber. "Renal histology with varying FK506 blood levels." Transplantation Proceedings 29, no. 1-2 (February 1997): 186. http://dx.doi.org/10.1016/s0041-1345(97)82525-0.

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11

Chan, K. W. "Cost effectiveness of routine necropsy renal histology." Journal of Clinical Pathology 41, no. 2 (February 1, 1988): 233. http://dx.doi.org/10.1136/jcp.41.2.233.

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12

Krishnappa, Premkumar, Mohan keshavamurthy, Shakir Tabrez, Sreeharsha Harinatha, and Mohan Balaiah Aswathaiya. "Primary Renal Synovial Sarcoma - A rare histology." Urology Case Reports 33 (November 2020): 101402. http://dx.doi.org/10.1016/j.eucr.2020.101402.

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13

Daugherty, Michael R., Stephen Blakely, Oleg Shapiro, and Gennady Bratslavsky. "Comparision of histologic distribution of RCC in young and older patients: Results from the SEER database." Journal of Clinical Oncology 31, no. 6_suppl (February 20, 2013): 419. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.419.

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419 Background: Renal cell cancer (RCC) incidence is relatively low in younger patients, encompassing 3-5% of all RCC tumors. These tumors tend to be due to hereditary syndromes and genetic mutations that predispose to cancer development. Patients with hereditary renal cancer (HRC) are at a higher risk of multiple tumors and bilateral disease. We hypothesize that there is a difference in histologic distribution in the younger patients and that the younger distribution contains more aggressive histologic subtypes. Methods: SEER 18-registries database was queried for all patients ≥20 years old that were surgically treated for renal cell carcinoma between the years 2001 and 2008. Patients with unknown race, grade, stage, or histology were excluded from the study. Histologies selected were clear cell, papillary, chromophobe, sarcomatoid, and collecting duct. Three cohorts were created with the ages 20-44, 45-64, and ≥65 year olds that contained 3,926, 19,661, and 16,323 patients respectively. Chi-square analysis was used to compare the histologic distributions between the cohorts. Results: There was no difference in the incidence of clear cell RCC between the three cohorts (p = 0.63). The histology distribution was not different in the 45-64 year olds compared to those ≥65 (p = 0.47). The non-clear cell histologies were different between the 3 age groups (p < 0.001). There were a larger percentage of patients in the younger patients that had chromophobe tumors compared to all non-clear cell histologies (p< 0.001). Conclusions: The difference in the non-clear cell histologic distribution between the groups is most likely due to genetic mutations predisposing these patients to chromophobe RCC. There has been limited data on HRCs, due in large part to its low incidence. Although the HRCs are known to have a most common histology, it is likely that this information is incomplete, as younger patients have undiagnosed genetic mutations that led to development of chromophobe tumors. [Table: see text]

14

Zeier, Martin, Peter Fehrenbach, Steffen Geberth, Klaus Möhring, Rüdiger Waldherr, and Eberhard Ritz. "Renal histology in polycystic kidney disease with incipient and advanced renal failure." Kidney International 42, no. 5 (November 1992): 1259–65. http://dx.doi.org/10.1038/ki.1992.413.

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15

Ahmad, H. R., J. A. Faruk, M. A. Bugaje, A. Solomon, M. O. A. Samaila, and R. M. Akuse. "Sarcomatoid Renal Cell Carcinoma in an Adolescent with Sickle Cell Anaemia." Case Reports in Oncological Medicine 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/2129450.

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Malignancies have been reported to occur in people with sickle cell disease. Renal medullary carcinoma (RMC), also tagged seventh sickle cell nephropathy, is an aggressive cancer seen almost exclusively in people with sickle cell disease with more than 160 cases reported worldwide, but only few cases were reported in patients with sickle cell anaemia (HBSS) and from Nigeria. Sarcomatoid renal cell carcinoma is a renal tumour of any histologic variant containing foci of high-grade malignant spindle cells. We report an adolescent girl with sickle cell anaemia (HBSS) who presented with left renal tumour, histology of which confirmed a diagnosis of sarcomatoid renal cell carcinoma (sRCC). Surgical debulking and palliative care with chemotherapy were given, and she demised 10 months after. The rarity of the case and challenges of managing a cancer in the background of a chronic haematologic disorder are highlighted.

16

Brown, Catherine M., Lieneke Scheven, Patrick O’Kelly, Anthony M. Dorman, and John J. Walshe. "Renal histology in the elderly: indications and outcomes." Journal of Nephrology 25, no. 2 (June 28, 2011): 240–44. http://dx.doi.org/10.5301/jn.2011.8447.

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17

Sahay, M., RK Mahankali, K. Ismal, PS Vali, RK Sahay, and G. Swarnalata. "Renal histology in diabetic nephropathy: "A novel perspective"." Indian Journal of Nephrology 24, no. 4 (2014): 226. http://dx.doi.org/10.4103/0971-4065.132999.

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18

Loftus, Christopher, Michael Byrne, and Manoj Monga. "High pressure endoscopic irrigation: impact on renal histology." International braz j urol 47, no. 2 (March 2021): 350–56. http://dx.doi.org/10.1590/s1677-5538.ibju.2020.0248.

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19

Isoniemi, H., J. Ahonen, B. Eklund, P. Häyry, K. Höckerstedt, L. Krogerus, K. Salmela, and E. Taskinen. "Relationship between renal histology and later graft outcome." Transplant International 7, s1 (December 1994): 318–19. http://dx.doi.org/10.1111/j.1432-2277.1994.tb01379.x.

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20

Ghazanfari, Farshad, Zulfikar Jabbar, and Johannes Nossent. "Renal histology in Indigenous Australians with lupus nephritis." International Journal of Rheumatic Diseases 21, no. 1 (August 1, 2017): 194–99. http://dx.doi.org/10.1111/1756-185x.13147.

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21

Aubia, J., J. Masramón, S. Serrano, J. Lloveras, LL Marinoso, B. Bourbigot, M. C. Moal, and J. Cledes. "BONE HISTOLOGY IN RENAL TRANSPLANT PATIENTS RECEIVING CYCLOSPORIN." Lancet 331, no. 8593 (May 1988): 1048–49. http://dx.doi.org/10.1016/s0140-6736(88)91862-4.

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22

Kuypers, Dirk R. J., Jeremy R. Chapman, Philip J. O'Connell, Richard D. M. Allen, and Brian J. Nankivell. "PREDICTORS OF RENAL TRANSPLANT HISTOLOGY AT THREE MONTHS." Transplantation 67, no. 9 (May 1999): 1222–30. http://dx.doi.org/10.1097/00007890-199905150-00005.

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23

Raj, G. V., A. Iasonos, A. Bach, L. Hann, and P. Russo. "Predicting the histology of renal masses using pre-operative Doppler ultrasonography." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 4598. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4598.

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4598 Background: Traditional imaging techniques cannot differentiate between benign, indolent and malignant renal neoplasms. Since conventional clear cell carcinomas are highly vascular, we evaluated the association between vascular flow within a renal mass on pre-operative color and/or power Doppler ultrasonography (CDUS) and surgical pathology. Methods: Nephrectomies performed at our institution between 1/2001 and 12/2004 were retrospectively evaluated. Detection of flow within the renal mass on CDUS was defined as vascular flow. A prospective validation study was performed from 1/2005 to 10/2005, and a nomogram predicting clear cell histology created using vascular flow along with clinical and radiologic parameters. Results: Of 299 renal lesions in the retrospective cohort, 210 (70%) had evidence of vascular flow, including 156 of 169 (92%) conventional clear cell carcinomas (p < 0.0001). On logistic regression analyses, vascular flow was associated with conventional clear cell histology with an odds ratio of 16.9, CI: 8.7–32.8, p < 0.0001. These findings were validated prospectively in 97 patients; CDUS detected vascular flow in 54 of 65 (83%) renal masses with conventional clear cell histology (p < 0.0001) and was associated with an odds ratio of 10.8 (95% CI 4.0–29.0; p < 0.0001). On multivariable analyses, vascular flow was still a statistically significant predictor of conventional clear cell histology. A nomogram incorporating vascular flow along with clinical and radiologic variables (clinical size, patient gender and age) to predict conventional clear cell histology was constructed on the retrospective cohort and validated on the prospective data set (concordance index 0.82 and 0.76 respectively). Conclusions: Vascular flow within a renal mass detected by CDUS is strongly associated with conventional clear cell histology with an odds ratio of 10.8–16.9. A nomogram incorporating vascular flow on CDUS and clinical and radiographic parameters may aid in the non-invasive characterization of renal lesions. [Table: see text] No significant financial relationships to disclose.

24

Gupta, Ruby, Filip Ionescu, Vishal Jindal, John Khoury, Nwabundo Ifeyinwa Anusim, and Ishmael A. Jaiyesimi. "Survival outcomes of sarcomatoid renal cell cancer (sRCC) compared to clear cell renal cell cancer (ccRCC): An analysis of SEER data." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e17101-e17101. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e17101.

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e17101 Background: Renal cell carcinoma (RCC) with sarcomatoid differentiation is a highly aggressive form of RCC. The presence of even a small component of sRCC was shown to independently predict poor survival compared to RCC without sarcomatoid features. We studied the epidemiology and survival outcome of sRCC compared to ccRCC by reviewing the SEER data. Methods: Patients (pts) with histologically confirmed sRCC and ccRCC between 2012-2015 were reviewed in SEER database. Variables included age, gender, ethnicity, histologic grade, stage at diagnosis, and nephrectomy. Primary outcome was 5 year Disease Specific Survival (DSS). Data was analyzed using Kaplan Meier curves and Cox proportional hazards model. Results: A total of 31, 293 pts with RCC were identified in SEER database between 2012 to 2015. 611 pts had sRCC while 30, 682 had ccRCC. The two groups had almost similar demographic features, including mean age (63 ±12 for sRCC vs 61±12 years for ccRCC), male: female ratio (vs 2.3:1 vs 1.7:1) and Caucasian ethnicity (82% vs 85%). More than half of sRCC patients (62%) were metastatic at diagnosis compared to only 11% of ccRCC, which presented most commonly as stage I disease (63%). The histologic grade was higher in sRCC patients (43% grade 4 vs 45% grade 2 in ccRCC subjects). Nephrectomy rates were almost similar for stages I-III in the two groups (94% in sRCC vs 93% in ccRCC) while lower in stage IV sRCC (44% vs 54%). Across all stages and at every time point, sRCC was associated with increased mortality in the univariate analysis. In the multivariate regression analysis (table), advanced stage was the strongest independent predictor of mortality (HR 11.9), followed by high histologic grade (HR 3.6) and sarcomatoid histology (HR 2.9). Nephrectomy was protective (HR 0.3). Age was associated with worse outcomes (HR 1.016 per unit change). Conclusions: sRCC are more aggressive and tend to present as metastatic disease. sRCC has worse outcomes across all stages compared to ccRCC even after adjusting for potential confounders. Advanced stage and histologic grade remain the two strongest predictors of disease-specific mortality, sarcomatoid histology demonstrated a significant impact on outcome. [Table: see text]

25

Marangoni, Marco Aurelio, Alex Hausch, Pedro Thadeu Galvão Vianna, José Reinaldo Cerqueira Braz, Rosa Marlene Viero, and Yara Marcondes Machado Castiglia. "Renal function and histology after acute hemorrhage in rats under dexmedetomidine action." Acta Cirurgica Brasileira 22, no. 4 (August 2007): 291–98. http://dx.doi.org/10.1590/s0102-86502007000400011.

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PURPOSE: About 50 % of indications for dialysis in acute renal failure are related to problems originated during the perioperative period. Intraoperative hemodynamic changes lead to renal vasoconstriction and hypoperfusion. Previous studies have not defined the dexmedetomidine renal role in hemorrhage situations. This study evaluated the effect of dexmedetomidine on renal function and histology after acute hemorrhage in rats. METHODS: Covered study with 20 Wistars rats, anesthetized with sodium pentobarbital, 50 mg. kg-1, intraperitoneal, randomized into 2 groups submitted to 30% volemia bleeding: DG - iv dexmedetomidine, 3 µg. kg-1 (10 min) and continuous infusion - 3 µg. kg-1. h-1; CG - pentobarbital. For renal clearance estimative, sodium p-aminohippurate and iothalamate were administered. Studied attributes: heart rate, mean arterial pressure, rectal temperature, hematocrit, iothalamate and p-aminohippurate clearance, filtration fraction, renal blood flow, renal vascular resistance, and histological evaluations of the kidneys. RESULTS: DG showed smaller values of heart rate, mean arterial pressure, and renal vascular resistance, but iothalamate clearance and filtration fraction values were higher. There was similarity in p-aminohippurate clearance and renal blood flow. Both groups had histological changes ischemia-like, but dexmedetomidine determined higher tubular dilatation scores. CONCLUSION: In rats, after acute hemorrhage, dexmedetomidine determined better renal function, but higher tubular dilation scores.

26

Patard, J., N. Rioux-Leclercq, K. Bensalah, and P. Fergelot. "Biological significance of serum VEGF measurement in renal cell carcinoma." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 4596. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4596.

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4596 Background: VEGF plays an important role in Renal Cell Carcinoma (RCC) tumor angiogenesis and is a relevant molecular target. Our objective was to correlate serum VEGF measurement to clinical, biological and pathological variables in renal tumors. Methods: 206 patients who were operated for a renal tumor at our institution were prospectively assessed for serum VEGF measurement (enzyme-linked immunosorbent assay, R&D systems). Informed consent was obtained in all cases. Symptoms at presentation, pre-operative biology (haemoglobin, WBC count, platelet count, serum creatinin, calcemia, CRP, ASAT, ALAT, gamma-glutamyltransferase (γGT), Alkaline Phosphatases), TNM stage, Fuhrman grade and final pathology (benign vs malignant histology, histologic subtype) were systematically recorded. Qualitative and quantitative variables were compared by using Chi-square (Fischer exact test) and Student t tests, respectively. Results: There were 128 males (62.1%) and 78 females (37.9%). 185 tumors were malignant at histology (89.8%) including 155 tumors with clear cell histology (83.8%). Median serum VEGF level was 361 ng/ml (41–3090). Mean serum VEGF was not significantly different between benign and malignant tumors as well as between clear cell and non clear cell carcinomas (p: 0.4 and 0.8 respectively). Serum VEGF was strongly associated with symptoms, T Stage (p: 0.0001), N Stage (p: 0.004), Fuhrman grade (p: 0.007) and tumor necrosis (p: 0.004) but not with M Stage (p: 0.3). Serum VEGF was also found to be strongly associated with: haemoglobin, CRP, platelet count (p: 0.0001) and Alkaline phosphatases (p: 0.001). A weaker association was found between serum VEGF and γGT, ASAT (p: 0.05) or ALAT (p: 0.09). Finally serum VEGF was associated with cancer specific survival (p: 0.01). Conclusion: Serum VEGF is strongly associated with most usual clinical, biological and pathological prognostic parameters in RCC. Serum VEGF measurement should be further evaluated for prognostic purpose as well as for treatment monitoring. No significant financial relationships to disclose.

27

Dudani, Shaan, Guillermo de Velasco, Connor Wells, Chun Loo Gan, Frede Donskov, Camillo Porta, Anna Fraccon, et al. "Characterizing sites of metastatic involvement in metastatic clear-cell, papillary, and chromophobe renal cell carcinoma." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 5071. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.5071.

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5071 Background: There exists considerable biological and clinical variability between histologic variants of metastatic renal-cell carcinoma (mRCC). Data reporting on sites of metastatic involvement in less common histologies of mRCC are sparse. We sought to characterize the frequency of metastatic site involvement across the three most common histologies of mRCC: clear-cell (ccRCC), papillary (pRCC), and chromophobe (chrRCC). Methods: Using the International mRCC Database Consortium (IMDC) database, patients with mRCC starting systemic therapy between 2002-2019 were identified and sites of metastases at the time of systemic therapy initiation were documented. Patients with multiple sites of metastatic involvement were included in analyses of all groups to which they had metastases. The primary outcomes were prevalence of metastatic site involvement and overall survival (OS). Patients with mixed histology were excluded. Results: 10,105 patients were eligible for analysis. Median age at diagnosis was 60, 72% were male and 79% underwent nephrectomy. 92%, 7% and 2% of patients had ccRCC, pRCC, and chrRCC, respectively. Frequency of metastatic site involvement across the histologic subtypes is shown in Table. Lung, adrenal, brain and pancreatic metastases were more frequent in ccRCC, lymph node involvement was most frequent in pRCC, and liver metastases were most frequent in chrRCC. Median OS for ccRCC varied by site of metastatic involvement, ranging between 16 months (brain/pleura) and 50 months (pancreas). OS by site of metastatic involvement was compared between histologies for the four most common sites of metastases (lung, lymph nodes, bone, liver). As compared to patients with ccRCC, patients with pRCC had lower OS regardless of site of metastasis (p < 0.05). Power was limited and thus differences in OS between ccRCC and chrRCC were not detectable. Conclusions: Sites of metastatic involvement differ based on histology in mRCC. These data highlight the clinical and biologic variability between histologic subtypes of mRCC and constitute the largest cohorts of patients with metastatic pRCC and chrRCC to report on sites of metastases. Sites of Metastatic Involvement by Histology. [Table: see text]

28

Heng, Daniel Y. C., and Toni K. Choueiri. "Non–Clear Cell Renal Cancer: Features and Medical Management." Journal of the National Comprehensive Cancer Network 7, no. 6 (June 2009): 659–65. http://dx.doi.org/10.6004/jnccn.2009.0046.

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The treatment of metastatic renal cell carcinoma (RCC) has changed dramatically with the introduction of targeted therapies against vascular endothelial growth factor and the mammalian target of rapamycin. Because patients with clear cell histology account for more than 80% of patients with RCC, little evidence is available on treating patients with non–clear cell histologies. Most clinical trials have excluded them from enrollment, except for a randomized study investigating temsirolimus. Many retrospective studies on the use of sunitinib, sorafenib, and temsirolimus in patients with non–clear cell histology have shown response rates ranging from 3.7% to 16%. Prospective studies in non–clear cell histologies are ongoing. Although response rates may not be as high as those in patients with clear cell histologies, targeted therapy may provide a clinically meaningful response. New investigational therapies are on the horizon for papillary RCC—the most-common non–clear cell RCC histology—targeting pathways specific to this histology, such as the c-MET pathway.

29

Rasheed, Ammara, Mohtasham Hina, Muhammad Rizwan Bashir Kiani, Raafea Tafweez, Imtiaz Aslam, and Arslan Akbar Saeed. "Effect of Red Bull on Histology of Renal Mesangium." Journal of Rawalpindi Medical College 25, no. 1 (March 30, 2021): 77–82. http://dx.doi.org/10.37939/jrmc.v25i1.1496.

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Objective: To determine the consequences of energy drink (Red bull) on renal mesangium of albino rats.Materials and Methods: This study was carried out at the Anatomy Department of King Edward Medical University, Lahore, from August 2018 to December 2019. It was an experimental randomized controlled trial. Total 90 adult albino male rats, 8-12 weeks old, weighing 130 to 160 grams were taken. Healthy animals were included. Rats were divided into three groups Group A and B experimental groups received 1.5ml/kg and 2.2ml/kg body weight of red bull energy drink, respectively. Group C received 1ml/kg body weight of distilled water.Results: The mean initial and final weight of animals was around 150g and 170g, respectively. The mean paired kidney weight and relative tissue weight index for all three groups were found insignificant. Microscopic examination showed mesangial hypercellularity and vascular congestion in renal cortex of groups A and B, none in group C. These were significant among two experimental groups with a p-value less than 0.001.Conclusion: It was found that the use of energy drinks induces histopathological changes in the renal mesangium.

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Ooms, Ariadne H. A. G., Gordan M. Vujanić, Ellen D’Hooghe, Paola Collini, Aurore L’Herminé-Coulomb, Christian Vokuhl, Norbert Graf, Marry M. van den Heuvel-Eibrink, and Ronald R. de Krijger. "Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach." Cancers 12, no. 3 (March 19, 2020): 729. http://dx.doi.org/10.3390/cancers12030729.

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Renal tumors comprise approximately 7% of all malignant pediatric tumors. This is a highly heterogeneous group of tumors, each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore pathologists with expertise in pediatric oncology are needed for dealing with these rare tumors. While each tumor shows different histologic features, they do have considerable overlap in cell type and histologic pattern, making the diagnosis difficult to establish, if based on routine histology alone. To this end, ancillary techniques, such as immunohistochemistry and molecular analysis, can be of great importance for the correct diagnosis, resulting in appropriate treatment. To use ancillary techniques cost-effectively, we propose a pattern-based approach and provide recommendations to aid in deciding which panel of antibodies, supplemented by molecular characterization of a subset of genes, are required.

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Bhindi, Bimal, Robert Houston Thompson, Christine M. Lohse, Ross Mason, Igor Frank, Stephen A. Boorjian, John C. Cheville, and Bradley C. Leibovich. "The probability of indolent versus aggressive histology based on renal tumor size: Implications for surveillance and treatment." Journal of Clinical Oncology 36, no. 6_suppl (February 20, 2018): 704. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.704.

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704 Background: While the probability of benign versus malignant histology based on renal tumor size has been described, this alone does not sufficiently inform decision-making in the modern era since indolent malignant tumors can be surveilled. Thus, we sought to characterize the probability of indolent versus aggressive histology based on radiographic tumor size. Methods: We evaluated patients who underwent radical or partial nephrectomy at Mayo Clinic for a pT1-2, pNx/0, M0 solid renal tumor between 1990-2010. Pathology was reviewed by one genitourinary pathologist. Benign tumors, low grade (1-2) clear cell and papillary renal cell carcinoma (RCC), and any chromophobe, clear cell papillary, mucinous tubular and spindle cell, SDH-B deficient, and tubulocystic RCC were considered indolent. All other histologies were considered aggressive, as were any malignancies with necrosis or sarcomatoid differentiation. Cancer-specific survival (CSS) was estimated using the Kaplan Meier method. Logistic regression models were used to estimate the probability of malignant and aggressive histology based on tumor size. Sex-stratified analyses were also performed. Results: Of the 2650 patients included, there were 1773 patients with indolent tumors (303 benign; 1470 malignant) and 877 with aggressive tumors. Ten-year CSS was 96% for indolent malignant tumors and 82% for aggressive tumors. The predicted probabilities of any malignant histology and aggressive malignant histology increased with tumor size (Table; 1-7cm point estimates shown). For example, a 3 cm tumor had an 87% probability of malignancy and a 27% probability of being aggressive. For any given tumor size, men had a greater probability of aggressive histology than women. Conclusions: We present tumor size-based estimates of the probability of aggressive histology for renal masses. This information should be useful for patient counseling and treatment decision-making. [Table: see text]

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Nebuloni, Manuela, Antonella Tosoni, Renzo Boldorini, Guido Monga, Luca Carsana, Sara Bonetto, Clara Abeli, Rita Caldarelli, Luca Vago, and Giulio Costanzi. "BK Virus Renal Infection in a Patient With the Acquired Immunodeficiency Syndrome." Archives of Pathology & Laboratory Medicine 123, no. 9 (September 1, 1999): 807–11. http://dx.doi.org/10.5858/1999-123-0807-bvriia.

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Abstract Background.—We describe herein a patient with the acquired immunodeficiency syndrome and renal failure due to biopsy-proven BK virus (BKV) infection. Three months after the diagnosis of the renal viral infection, his condition remained unchanged. Although BKV has previously been shown to be associated with ureteral stenosis and renal damage in renal transplant patients, to our knowledge, the literature contains only 3 cases describing the presence of BKV lesions in the kidneys of immunosuppressed patients who had not undergone transplantation. Methods.—The presence of BKV infection was demonstrated by means of histology, immunohistochemistry with polyclonal anti-SV40 antibody, immunoelectron microscopy, polymerase chain reaction, and enzymatic cleavage with BamHI. Results.—Histologic examination revealed interstitial inflammatory infiltrates and tubules with enlarged and eosinophilic nuclei. Conclusions.—The high frequency of latent BKV infection and its reactivation during immunosuppression suggest that the possibility of its involvement in renal damage should be considered in immunocompromised patients.

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Fanous, Rafik Nabil, Erik K. Mayer, Justin Vale, Josephine Lloyd, and Marjorie M. Walker. "Primary Renal Embryonal Rhabdomyosarcoma in Adults: A Case Report and Review of the Literature." Case Reports in Oncological Medicine 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/460749.

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Adult renal rhabdomyosarcoma is a rare subtype of renal sarcoma. We present a case of a renal mass treated with radical nephrectomy that subsequently was shown to be renal rhabdomyosarcoma. We discuss the clinical presentation, imaging findings, and histology for this case and review the available literature.

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Al-khader, A. A., M. Al-Sulaiman, and J. M. Dhar. "Renal Histology in Saudi Population with Overt Nephrotic Syndrome." Annals of Saudi Medicine 10, no. 5 (September 1990): 581. http://dx.doi.org/10.5144/0256-4947.1990.581.

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35

Malluche, Hartmut H., Hanna Mawad, and Marie-Claude Monier-Faugere. "Effects of Treatment of Renal Osteodystrophy on Bone Histology." Clinical Journal of the American Society of Nephrology 3, Supplement 3 (November 2008): S157—S163. http://dx.doi.org/10.2215/cjn.02500607.

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36

Eisenberger, Ute, Fadi Fakhouri, Philippe Vanhille, Hélène Beaufils, Alfred Mahr, Loic Guillevin, Philippe Lesavre, and Laure-Hélène Noël. "ANCA-negative pauci-immune renal vasculitis: histology and outcome." Nephrology Dialysis Transplantation 20, no. 7 (April 26, 2005): 1392–99. http://dx.doi.org/10.1093/ndt/gfh830.

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37

Abou Heidar, Nassib F., Muhieddine Labban, Mazen M. Mansour, Sami Bannoura, and Jad A. Degheili. "Radiologically missed synchronous ipsilateral renal tumours with varying histology." Journal of Clinical Urology 13, no. 1 (July 12, 2019): 72–75. http://dx.doi.org/10.1177/2051415819863581.

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38

Dempster, A. G., B. Delahunt, A. W. Malthus, and J. St J. Wakefield. "The Histology and Growth Kinetics of Canine Renal Oncocytoma." Journal of Comparative Pathology 123, no. 4 (November 2000): 294–98. http://dx.doi.org/10.1053/jcpa.2000.0416.

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39

Hironaka, Kazue, Hirofumi Makino, Toshio Ogura, and Zensuke Ota. "Renal Histology in a Patient with Nephrogenic Diabetes insipidus." Nephron 71, no. 2 (1995): 224–26. http://dx.doi.org/10.1159/000188717.

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40

Gorin, Michael A., Steven P. Rowe, and Mohammad E. Allaf. "Noninvasive determination of renal tumor histology utilizing molecular imaging." Urologic Oncology: Seminars and Original Investigations 34, no. 12 (December 2016): 525–28. http://dx.doi.org/10.1016/j.urolonc.2016.08.014.

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41

Lu, A. D., D. Desai, B. D. Myers, D. C. Dafoe, and E. J. Alfrey. "Excellent outcome despite adverse histology after cadaveric renal transplantation." Transplantation Proceedings 33, no. 1-2 (February 2001): 1148. http://dx.doi.org/10.1016/s0041-1345(00)02466-0.

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42

Reuter, Victor E., and Satish K. Tickoo. "Differential diagnosis of renal tumours with clear cell histology." Pathology 42, no. 4 (June 2010): 374–83. http://dx.doi.org/10.3109/00313021003785746.

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43

Stoll, Peter M., Peter E. Stokes, and Michiko Okamoto. "Lithium isotopes: differential effects on renal function and histology." Bipolar Disorders 3, no. 4 (August 2001): 174–80. http://dx.doi.org/10.1034/j.1399-5618.2001.30402.x.

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44

Solaini, Leonardo, Anna Bianchi, Luigi Filippini, Laura Lucini, Edda Simoncini, and Fulvio Ragni. "A Mammary Nodule Mimicking Breast Cancer." International Surgery 99, no. 3 (May 1, 2014): 200–202. http://dx.doi.org/10.9738/intsurg-d-12-00019.1.

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Abstract Metastases to the breast from extramammary tumors are rare. Several clinical, radiologic, and histologic signs can help to distinguish metastases from breast primary tumors. In the present study, we present a case of a left-sided breast metastasis from renal cancer in a 44-year-old woman whose clinical presentation was a mammary nodule in the upper internal quadrant. The patient underwent quadrantectomy with sentinel lymph node biopsy. The histology revealed a clear cell carcinoma. On computed tomography scan a 5×8-cm left renal mass with pulmonary, liver, and intrapericardial nodules was found. The patient underwent palliative care and died after 4 months. Metastasis to the breast is rare, but all of those clinical, radiologic, and histologic signs more typical of extramammary malignancies should always be considered in order to choose the best treatment strategy.

45

Hall, JE, DH Zappe, M. Alonso-Galicia, JP Granger, MW Brands, and SE Kassab. "Mechanisms of Obesity-Induced Hypertension." Physiology 11, no. 6 (December 1, 1996): 255–61. http://dx.doi.org/10.1152/physiologyonline.1996.11.6.255.

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Obesity is a major cause of human essential hypertension. Recent studies point toward increased renal tubular reabsorption and abnormal renal pressure natriuresis in mediating obesity hypertension. The mechanisms for these renal changes appear to be multifactorial, including activation of the sympathetic nervous system and altered intrarenal histology, which compresses the renal medulla.

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Katsimantas, Antonios, Spyridon Paparidis, Konstantinos Bouropoulos, and Nikolaos Ferakis. "Multiple and Bilateral Sporadic Renal Cell Carcinomas: A Surgical Challenge." Case Reports in Urology 2018 (December 20, 2018): 1–4. http://dx.doi.org/10.1155/2018/4325762.

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Sporadic, synchronous, bilateral, or unilateral Renal Cell Carcinomas constitute a rare clinical entity. We report the case of a 68-year-old male patient who presented in our department due to incidentally discovered multiple, bilateral renal tumors. Magnetic Resonance Imaging demonstrated cT1b renal tumors at the lower pole of each kidney and a cT1a renal tumor at the upper pole of the right kidney. The patient underwent transperitoneal, laparoscopic left partial nephrectomy with renal artery occlusion, histology revealed high-grade, pT1b, clear-cell renal cell carcinoma; however we observed decline of patient’s estimated glomerular filtration rate postoperatively. Forty days postoperatively, he underwent open partial nephrectomy for the right sided tumors with manual compression of the renal parenchyma and no use of ischemia. Histology revealed high-grade, pT1a, clear-cell renal cell carcinoma at the upper pole of the right kidney and low-grade, pT1b, clear-cell renal cell carcinoma at the lower pole of the right kidney. There was no additional decline in the serum creatinine value postoperatively. The patient avoided permanent or temporary dialysis and 6 months postoperatively he demonstrated no recurrence on imaging and his renal function remained stable.

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Graham, Jeffrey, Connor Wells, Frede Donskov, Jae-Lyun Lee, Anna Paola Fraccon, Felice Pasini, Camillo Porta, et al. "Cytoreductive nephrectomy in metastatic papillary renal cell carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC)." Journal of Clinical Oncology 36, no. 6_suppl (February 20, 2018): 581. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.581.

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581 Background: There is evidence that cytoreductive nephrectomy (CN) may be beneficial in metastatic renal cell carcinoma (mRCC), but the role of CN in patients with papillary histology is unclear. Methods: Using the IMDC database, a retrospective analysis was performed on patients with papillary mRCC treated with or without CN. Baseline characteristics and IMDC risk factors were collected. Median overall survival (OS) was determined for both patient groups. Multivariable Cox regression analysis was performed to control for imbalances in individual IMDC risk factors. Results: In total, 353 patients with papillary mRCC with (n = 75) or without (n = 278) a component of clear cell histology were identified. Median follow-up time was 57.1 months (95% CI 32.9-77.8) and the OS from the start of first-line targeted therapy for the entire cohort was 13.2 months (95% CI 12.0-16.1). Baseline characteristics are in Table 1 and patients who had CN were more likely to be younger, with better KPS, and have sarcomatoid histology. Median OS in patients with CN was 16.3 months (95% CI 13.1-19.2), compared to 8.6 months (95% CI 6.1-12.2; p < 0.0001) in the no CN group. When adjusted for individual IMDC risk factors, the hazard ratio (HR) of death for CN was 0.62 (95% CI 0.45-0.85; p = 0.0031). Conclusions: The use of CN in patients with mRCC and papillary histology appears to be associated with improved survival when compared to no CN after adjustment for risk criteria. A clinical trial in this rare population may not be possible but this data does corroborate with clear cell literature. [Table: see text]

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Malone, B., S. Kleyman, A. Sanni, N. Sumrani, and D. Distant. "SalmonellaAppendicitis in Renal Transplantation." Case Reports in Transplantation 2013 (2013): 1–2. http://dx.doi.org/10.1155/2013/402735.

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While appendicitis remains one of the commonest surgical diseases, there are relatively few reports following renal transplantation. A 33-year-old man was admitted with diarrhea, fever, and epigastric pain 7 years following a cadaveric renal transplant. CT scanning confirmed a diagnosis of appendicitis which was removed within 24 hours of admission. Histology and blood cultures following surgery confirmedSalmonellatype b appendicitis. Patient was safely discharged home 5 days following hospital admission.

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Flint, S., M. Jose, G. Kirkland, D. Yip, A. Landgren, M. Finlay, and S. Cohney. "ABO-INCOMPATIBLE RENAL TRANSPLANTATION WITHOUT SPLENECTOMY OR RITUXIMAB – EXCELLENT RENAL FUNCTION AND GRAFT HISTOLOGY." Transplantation 86, Supplement (July 2008): 182. http://dx.doi.org/10.1097/01.tp.0000332341.78830.ff.

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50

Woldu, Solomon L., Aaron C. Weinberg, Arindam RoyChoudhury, Herbert Chase, Sean D. Kalloo, James M. McKiernan, and G. Joel DeCastro. "Renal insufficiency is associated with an increased risk of papillary renal cell carcinoma histology." International Urology and Nephrology 46, no. 11 (July 8, 2014): 2127–32. http://dx.doi.org/10.1007/s11255-014-0780-4.

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