Дисертації з теми "Regulatory T cell"
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Carson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.
Повний текст джерелаStefkova, Martina. "Regulatory T cells control the CD4 T cell repertoire." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/233151/3/Table.pdf.
Повний текст джерелаRecent studies conducted in mice and humans have suggested a role for the TCR repertoire diversity in immune protection against pathogens displaying high antigenic variability. To study the CD4 T cell repertoire, we used a mouse model in which T cells transgenically express the TCRβ chain of a TCR specific to a MHCII-restricted peptide, env122-141. Upon immunization with peptide-pulsed dendritic cells, antigen-specific Vα2+ CD4+ T cells rapidly expand and display a restricted TCRα repertoire. In particular, analysis of receptor diversity by high-throughput TCR sequencing in immunized mice suggests the emergence of a broader CDR3 Vα2 repertoire in Treg-depleted mice. These results suggest that Tregs may play a role in the restriction of the CD4 T cell repertoire during an immune response, raising therefore the possibility that in addition to controlling the magnitude of an immune response, regulatory cells may also control the diversity of TCRs in response to antigen stimulation.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Sarris, Milka. "Dynamics of helper T cell and regulatory T cell interactions with dendritic cells." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611896.
Повний текст джерелаNadal-Melsio, Elisabet. "Regulatory T cells after allogeneic stem cell transplantation." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523746.
Повний текст джерелаMavin, Emily. "Regulatory T cells in haematopoietic stem cell transplantation." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2731.
Повний текст джерелаRaynor, Jana L. "Regulatory T Cell Homeostasis in Aging." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416570329.
Повний текст джерелаSmith, Trevor Robert Frank. "Modulation of CD4+ T cell responses by CD4+CD25+ regulatory T cells and modified T cell epitopes." Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/11317.
Повний текст джерелаSoper, David Michael. "Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8344.
Повний текст джерелаCabbage, Sarah E. "Reversible regulatory T cell-mediated suppression of myelin basic protein-specific T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5034.
Повний текст джерелаVanderleyden, Ine. "Follicular regulatory T cell migration and differentiation." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288422.
Повний текст джерелаWright, G. P. "Generation of antigen-specific regulatory T cells by T cell receptor gene transfer." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18952/.
Повний текст джерелаPaiva, Ricardo de Sousa. "T cell Maturation and Regulatory T Cell Differentiation:From the Thymus to the Periphery." Doctoral thesis, Universidade Nova de Lisboa.Instituto de Tecnologia Química e Biológica, 2012. http://hdl.handle.net/10362/10587.
Повний текст джерелаDissertation presented to obtain the Ph.D degree in Immunology
Lindqvist, Camilla. "T Regulatory Cells – Friends or Foes?" Doctoral thesis, Uppsala universitet, Enheten för klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128837.
Повний текст джерелаSather, Blythe Duke. "CD4+ Foxp3+ regulatory T cell homing & homeostasis /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8343.
Повний текст джерелаWarth, Sebastian. "A microRNA network in regulatory T cell differentiation." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-185611.
Повний текст джерелаKolodin, Dmitriy Pavlovich. "Dynamics of Tissue-Resident Regulatory T Cell Populations." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11555.
Повний текст джерелаHimmel, Megan Elizabeth. "Phenotypic and functional characterization of T cells and Foxp3⁺ T regulatory cells in inflammatory bowel disease : steps towards T regulatory cell therapy in mucosal disease." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42517.
Повний текст джерелаSandalova, Elena. "Regulation of the pro-apoptotic protein bim by T cell receptor triggering in human T cells /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-041-1/.
Повний текст джерелаTerry, Alexandra Margaret. "The Roles of CD4+ T cells and Regulatory T cells in Antitumour Immunity." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/17331.
Повний текст джерелаVarikuti, Sanjay. "Role of CD4+CD25+ Regulatory T Lymphocytes in Experimental Toxoplasmosis." TopSCHOLAR®, 2009. http://digitalcommons.wku.edu/theses/113.
Повний текст джерелаNissen, Jesper Klintø. "Control of regulatory T cell lineage differentiation by Foxp3." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609792.
Повний текст джерелаSalisbury, Emma. "Forward genetic analysis of natural T regulatory cell development." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/18844.
Повний текст джерелаCook, Katherine. "The Regulatory T-cell response to Helicobacter pylori infection." Thesis, University of Nottingham, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664309.
Повний текст джерелаHuynh, Alexandria. "Mechanisms of regulatory T cell lineage homeostasis and stability." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467375.
Повний текст джерелаMedical Sciences
Danby, Robert David. "A study of regulatory T cells in allogeneic haematopoietic stem cell transplantation." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:341878ee-8c3e-4eef-ab16-b1b04e34bf4d.
Повний текст джерелаHuang, Anfei [Verfasser]. "Progranulin Prevents Regulatory NK Cell Cytotoxicity Against Antiviral T Cells / Anfei Huang." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/123423341X/34.
Повний текст джерелаMeredith, Tobias. "The regulatory effects of CD161 and MAIT cells." Thesis, Federation University Australia, 2020. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/176644.
Повний текст джерелаDoctor of Philosophy
Berglund, David. "Preparatory Studies to Introduce Regulatory T Cells in Clinical Transplantation." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220873.
Повний текст джерелаUttenthal, B. J. "T cell receptor-transduced regulatory T cells : functional studies in models of graft-versus-host disease." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1379030/.
Повний текст джерелаJain, Nitya. "Multifaceted Regulation of Peripheral T Cell Tolerance and Autoimmunity by FOXP3+ T Regulatory Cells: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/416.
Повний текст джерелаLei, Hong. "Human natural regulatory T cells subsets." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16958.
Повний текст джерелаRegulatory T cells (Treg) offer new immunotherapeutic options to control undesired immune reactions, but the heterogeinetiy of Treg raises the question which Treg population should be used for clinical translation Thus, this project involves three main parts: i) investigating Treg frequency and subsets distribution with age in healthy donors and transplant (Tx) patients; ii) comparing the suppressive capacity of Treg subsets and expanding them in vitro without losing functionality; iii) clarifyjing the differiation relationship of Treg subsets and their relation to conventional T cells (Tconv) by T cell receptor (TCR) repertoire analysis. From both healthy donors and Tx patients, an age-dependent shift from naïve Treg (TregN) to the dominant central-memory Treg (TregCM) was observed,; However,Treg in Tx patients contained more effector-memory EM cells, , and they were pre-activated due to the exposure to allo antigens,. Regarding control of early Tconv activation, TregCM showed enhanced suppressive capacity compared to TregN; furthermore, only TregCM could induce apoptosis of responder cells while TregN could not, which may result from thehigherexpression of cytotoxic T-lymphocyte antigen 4 (CTLA-4) on TregM. Following in vitro expansion of the Treg subsets, however, TregN converted mainly into TregCM phenotype with enhanced suppression activity. The poor proliferation capacity of TregEM might indicate EM as the terminal differential stage. These data suggest that expansion with total Treg is optimal for adoptive Treg therapy as the majority of them are the highly potent TregCM. Lastly, TCR repertoire study by next generation sequencing (NGS) indicate that TregM derived from TregN rather than Tconv in an antigen-driven process. The highest similarity of the TCR repertoires was observed between TregCM and TregEM. These data reveal new insights for the first time into the distinct TCR repertoires of Treg subsets and Tconv in human by NGS technology.
Chen, Ye. "Induced regulatory T cells in transplantation tolerance." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:cffc275b-d32c-495e-a1da-55421a57e7e7.
Повний текст джерелаMarshall, D. J. "The role of multiple cell types in the development of regulatory T-cells." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1417081/.
Повний текст джерелаHeil, Luke. "THE ROLE OF CD8 T CELL IMMUNODOMINANCE AND REGULATORY T CELLS IN NEONATAL IMMUNITY TO INFLUENZA VIRUS." UKnowledge, 2019. https://uknowledge.uky.edu/microbio_etds/22.
Повний текст джерелаGeorge, Mariam M. B. S. "Zinc regulates tolerogenic dendritic cell phenotype and skews regulatory T cell- Th17 balance." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439305564.
Повний текст джерелаBurocchi, Alessia. "Modulation of regulatory T cell suppression in tumors through OX40." Thesis, Open University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576669.
Повний текст джерелаSharif-Paghaleh, Ehsan. "In vivo imaging of regulatory T cell mediated transplant tolerance." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/in-vivo-imaging-of-regulatory-t-cell-mediated-transplant-tolerance(4ee28e3c-431f-430f-9484-d22f030787b1).html.
Повний текст джерелаMair, Iris. "Investigating mechanisms of regulatory T cell function in inflammatory disease." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28705.
Повний текст джерелаFranchini, Fanny. "Immune regulatory networks in inflammation-driven cancer." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:2314081e-8c3f-43c7-9ea6-edf43430a43c.
Повний текст джерелаSchreiber, Taylor Houghton. "Balancing Effector and Regulatory T Cell Responses in Cancer and Autoimmunity." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/654.
Повний текст джерелаChan, Ping-lung, and 陳秉隆. "Roles of TLR5 and ICOS on the human allogenic CD40-activated B cell-induced CD4hiCD25+ regulatory T cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47149735.
Повний текст джерелаCarretero-Iglesia, Laura. "Autologous regulatory myeloid cell therapy in transplantation." Nantes, 2014. http://archive.bu.univ-nantes.fr/pollux/show.action?id=57eee07a-2290-4c76-b10e-0603a68039b7.
Повний текст джерелаL'objectif en transplantation d'organes est d'induire une tolérance spécifique du greffon à long terme. Les thérapies actuelles sont efficaces pour contrôler le rejet aigu du greffon mais sont inefficaces pour prévenir le rejet chronique. De plus, elles peuvent induire à des effets secondaires importants, rendant les patients sensibles à d'autres maladies. De nouvelles thérapies sont ainsi en cours de développement. L'utilisation de différents types cellulaires modifiés in vitro comme stratégie pour l'induction d'une tolérance spécifique d'antigène a été démontré efficace pour prolonger la survie de l'allogreffe dans plusieurs modèles animaux. Les cellules myéloïdes jouent un rôle important en transplantation. Elles sont impliquées dans la tolérance, ainsi que dans le rejet de la greffe. La modification in vitro des cellules myéloïdes pour leur utilisation en transplantation a suscité un intérêt ces dernières années. Le travail développé pendant cette thèse a eu pour objectif la génération de trois types de cellules régulatrices myéloïdes (cellules dendritiques tolérogènes, macrophages régulateurs et cellules myéloïdes suppressives). In vitro, nous avons étudié leur capacité suppressive sur l'activation des lymphocytes T et les mécanismes impliqués dans cette suppression. In vivo, nous avons testé leur potentiel à prolonger la survie de l'allogreffe après injection autologue dans un modèle de greffe chez la souris ainsi que les mécanismes qu'elles induisent. Nous supposons alors que les résultats obtenus pendant cette thèse pourront aider à développer une thérapie cellulaire efficace pour l'induction d'une tolérance en transplantation
Hoffmann, Markus [Verfasser]. "Regulatory T cell-mediated suppression of Th9 cell development and effector function / Markus Hoffmann." Mainz : Universitätsbibliothek Mainz, 2014. http://d-nb.info/104816490X/34.
Повний текст джерелаOldham, Kimberley Anne. "The recruitment and role of effector and regulatory T cells in renal cell carcinoma." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3263/.
Повний текст джерелаHirani, S. "The characterisation of human umbilical cord blood regulatory T cell subsets." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344048/.
Повний текст джерелаWalter, Gina. "Do activated monocytes impair regulatory T cell function in rheumatoid arthritis?" Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/do-activated-monocytes-impair-regulatory-t-cell-function-in-rheumatoid-arthritis(bec96e89-858a-42a3-87cf-6167ee9d633e).html.
Повний текст джерелаWhatcott, Andrew. "Assessing the impact of immunosuppressive drugs on regulatory T cell therapy." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:d3e538bc-0558-4f12-8be4-5f77d79c4323.
Повний текст джерелаPowell, Michael D. "Insights Into the Regulatory Requirements for T Follicular Helper Cell Development." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/89085.
Повний текст джерелаPh. D.
Specialized cells called T helper cells serve as a critical interface between the innate (first line of defense) and adaptive (specialized and long-term) immune systems. During the course of an infection, T helper cells are responsible for orchestrating the immune-mediated elimination of invading viruses, bacteria, and parasites. This wide breadth of functionality is achieved through the formation of distinct T helper subsets including T helper 1 (TH1), TH2, TH17, and T follicular helper (TFH) populations. Individual subsets have distinct developmental requirements and have unique functions within the immune system. For example, TFH cells are required for the production of effective antibodies that recognize invading pathogens, leading to their subsequent elimination. This naturally occurring process is the basis for a number of modern medical therapies including vaccination. Conversely, aberrant generation of antibodies that recognize host tissues can result in the onset of various autoimmune diseases including lupus, multiple sclerosis, and crohn’s disease. Due to the importance of TFH cells to human health, there is intense interest in understanding how these cells are formed. It is recognized that the generation of these therapeutically important immune cells is mediated by numerous cell-extrinsic andintrinsic influences, including proteins in their cellular environment called cytokines, and important proteins inside of the cell called transcription factors. However, as this is a complicated and multi-step process, many questions remain regarding the identity of these cytokines and transcription factors. The work in this dissertation seeks to understand how cellextrinsic cytokine signals and cell-intrinsic transcription factor activities are integrated to properly regulate TFH cell development. Collectively, this body of work significantly advances our understanding of the regulatory mechanisms that govern TFH cell differentiation, setting the basis for the rational design of novel immunotherapeutic strategies and increasingly effective vaccines.
Hu, Mingjing. "Human regulatory T cell physiology - Lessons learnt from newborns and adults." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18396.
Повний текст джерелаStrainic, Michael George Jr. "THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1363707372.
Повний текст джерела