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Статті в журналах з теми "Régulation spatio-temporelle"
Zanin, Natacha, and Cedric M. Blouin. "Contrôle endosomal de la signalisation intracellulaire." Biologie Aujourd'hui 212, no. 1-2 (2018): 45–51. http://dx.doi.org/10.1051/jbio/2018023.
Повний текст джерелаMorin, Morgane, Hadia Moindjie, and Clara Nahmias. "Le transport mitochondrial." médecine/sciences 38, no. 6-7 (June 2022): 585–93. http://dx.doi.org/10.1051/medsci/2022085.
Повний текст джерелаFAVERDIN, P., and M. PICARD. "Dossier : Préhensibilité des aliments par les herbivores et les volailles - Avant-propos." INRAE Productions Animales 10, no. 5 (December 9, 1997): 375. http://dx.doi.org/10.20870/productions-animales.1997.10.5.4013.
Повний текст джерелаДисертації з теми "Régulation spatio-temporelle"
Rouault, Hervé. "Réseaux génétiques et dynamique spatio-temporelle d'ensembles cellulaires." Paris 7, 2009. http://www.theses.fr/2009PA077265.
Повний текст джерелаThis thesis presents a series of works dealing with some aspects of development and cellular differentiation. The first part exposes a bioinformatics algorithm, that we have developed, allowing to study the sequences from the genome responsible for the specific expression of genes in the various tissues constituting an organism. It aims at extracting the key components and some syntax of the cis-regulatory sequences. We present its application to the specification of sensory organ precursors in Drosophila melanogaster. A second part consists in the theoretical study of the structure of the networks of interactions between genes and proteins leading to cell fate specification. We have used a method of evolution in silico, to build genetic networks, needing or not cell-cell communication, mimicking cell differentiation. The underlying phenomena are responsible for the settlement and maintenance of the specialized functions of cells. Finally, in a third part, we propose a model of mechanical control of growth, likely to explain several surprising observation in the formation of organs. In particular, we have modeled the proliferation of cells constituting the Drosophila melanogaster wings and propose a mechanism which make the tissue growth rate uniform
Aguilera, Aguilera Paula. "Régulation spatio-temporelle de la recombinaison télomérique au cours de la sénescence réplicative." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0681.
Повний текст джерелаChromosome ends are formed by structures called telomeres, which are necessary for genome integrity and cell survival. Upon aberrant proliferation, as in precancerous cells, telomere alterations blocks cell proliferation, a mechanism called replicative senescence. However, some cells escape this control and become immortals. Using budding yeast as model, my work aimed to understand the mechanisms that allow cells to reconstitute functional telomeres using homologous recombination. The nucleus is divided in sub-compartments that are differently permissive for recombination. I investigated how the localization of dysfunctional telomeres to the nuclear pore complex (NPC) determines their repair and favors cell proliferation. I showed that replicative lesions at telomeres relocate to the NPC allowing conservative repair by recombination. I further shed light on the presence at NPC of telomeric DNA circles that may serve as template for telomere elongation and thus escape from senescence
Hatte, Guillaume. "Régulation spatio-temporelle de la cytodiérèse des cellules épithéliales chez l'embryon de Xenopus laevis." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B008.
Повний текст джерелаEpithelia act as mechanical and chemical barriers essential to the body. Those functions rely on the cohesion of cells by tight and adherens junctions, which are linked to the actomyosin network. During development and adult life, epithelia develop or regenerate through cell division. During division, epithelial cells undergo important cell shape remodeling without altering the epithelium integrity. During cell division, mechanical forces applied to the adherens junctions and forces produced by the contractile ring are opposed, contributing to the maintenance of the epithelium integrity. However, the mechanisms involved in the regulation of the forces involved during cell division are poorly understood. The aim of my thesis project was to characterize cytokinesis in vertebrate epithelial cells using the Xenopus laevis embryo as an in situ model. In the first part of this manuscript, we described in vivo a space transiently forms between the two daughter cells during cell division. This space is intimately linked to the cytokinetic ring. In the second part, we have deciphered the role of tight junctions on cytokinesis. Our results show that the scaffold protein ZO-1 and the regulatory protein GEF-H1, which is associated to tight junctions, negatively regulate global tension applied to adherens junctions. The active role of tight junctions in regulating adherens junction is supported by the finding that GEF-H1 acts by activating the Rho/RockII/myosin pathway and by regulating membrane trafficking via the exocyst complex. The increase tension observed in ZO-1 and GEF-H1 depleted cells is correlated with defect in cytokinesis duration and contractile ring shape during cytokinesis. Finally, our results suggest that GEF-H1 can locally control tensions at division site. In the last part, we have studied contractile ring formation and activation. Our results show that recruitment of contractile ring proteins begins apically and progresses along the lateral membrane. We are now studying the role of apical junctions in this recruitment
Dussutour, Audrey. "Organisation spatio-temporelle des déplacements collectifs chez les fourmis." Toulouse 3, 2004. http://www.theses.fr/2004TOU30242.
Повний текст джерелаVallentin, Alice. "Dynamique et régulation de la localisation spatio-temporelle de la PKC alpha dans les cellules hypophysaires GH3B6." Montpellier 1, 2001. http://www.theses.fr/2001MON1T002.
Повний текст джерелаGautier, Aude. "Régulation spatio-temporelle de l'expression des gènes dans la gonade : identification de séquences promotrices fonctionnelles in vivo." Rennes 1, 2011. http://www.theses.fr/2011REN1S030.
Повний текст джерелаRegulation of spermatogenesis relies on the coordinated action of paracrine factors showing distinct and highly restricted spatio-temporal expression patterns. In order to better understand the mechanisms responsible for cell-specific gene expression in the male gonad, we have carried out a functional approach to assess promoter activity in vivo by transgenesis. The 2kb-long 5’ flanking regions of genes specifically expressed in the gonad were cloned from zebrafish (Danio rerio) genome and inserted upstream the GFP (green fluorescent protein) reporter gene. Transgenic zebrafish lines were produced and we showed that the proximal promoters of gsdf (gonadal soma derived factor), fshr (follicle stimulating hormone receptor) and amhrII (anti-Müllerian hormone receptor II) were sufficient to target high expression levels of the transgene in Sertoli cells. Similarly, the promoters of vasa and sycp1 (synaptonemal complex protein 1) genes were sufficient to target distinct germ cell populations. In silico analysis of Sertoli-specific proximal promoters revealed evolutionarily conserved cis DNA motifs, some of them being shared between promoters. However, when these promoters were placed in a heterologous context, in medaka (Oryzias latipes), they did not generate an efficient expression of the transgene. This suggests that the interactions between trans and/or cis regulatory elements could not be conserved in Teleost. Endly, the GFP expressing transgenic lines will be valuable models to follow and characterize gonadal cell lineages
Testenière, Olivier. "Caractérisation d'une calciprotéïne du crustacé Orchestia cavimana : étude de l'expression spatio-temporelle et de la régulation hormonale du gène." Dijon, 1998. http://www.theses.fr/1998DIJOS050.
Повний текст джерелаEl, Kanbi Karim. "Les rythmes lents du sommeil NREM : caractérisation, régulation spatio-temporelle et stimulations auditives : Étude transversale du sommeil chez l’homme et la souris." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS644.
Повний текст джерелаSleep is an essential state in animals that is characterized by immobility, brain oscillations and homeostatic regulation. The slow rhythms of the NREM sleep phase are a strong marker of this homeostasis and sleep pressure. Several terms and methods are used to define and detect these slow rhythms, however, they are all supposed to be associated with the occurrence of a DOWN state of cortical neurons. The different detection methods are first evaluated and compared. Auditory stimuli, by exciting cortical neurons, are able to induce or destroy slow rhythms: by means of a brain-machine interface in mice, the stimulation process is then analysed to understand its mechanisms and effects. Then, a new approach is proposed to better understand the link between the spatial and temporal regulations of slow rhythms: the observed homeostasis of phenomena such as slow waves or delta waves could be explained by their spatial evolution. A final part focuses on the evolution of the dynamics of slow rhythms with ageing in humans. Using a database of hundreds of EEG device users, the analysis of large-scale electrophysiological sleep data shows a decline in several NREM sleep indicators with age. This thesis therefore provides new insights into the understanding of slow rhythms and their regulation in rodents and humans
Fant, Bruno. "Importance du contexte cellulaire et de la régulation spatio-temporelle de l'expression du facteur de transcription Otx2 dans la modulation de ses fonctions." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4100/document.
Повний текст джерелаThe molecular mechanisms explaining several functions of the homeogene Otx2 during embryonic development are the focus of this work. In a first part the importance of the regulation of its expression in the regionalisation of the central nervous system is studied. At the end of gastrulation the posterior border of Otx2 expression will position the isthmic organizer responsible for the induction of the midbrain and hindbrain. A mouse model was developed where this border is replaced by an ubiquitous expression of the gene. Contrary to the predictions of the current model, the organizer then correctly arises, and is shifted anteriorly. A concentration threshold of Otx2 thus appears necessary to its regionalising function. In a second part the importance of the cellular context in Otx2 function in the adult retina is examined. Otx2 is expressed in both tissues of this organ, the neural retina and RPE. A ChIP-seq analysis performed on both tissues revealed that this homeogene occupies very different sets of binding sites, which suggests distinct functions of the transcription factor. Most Otx2-bound sites in the neural retina were also bound by its paralogue Crx, with which a functional redundancy may therefore exist. A new mouse line finally allowed the study of the complete Otx2 interactome in the neural retina; this analysis showed that Otx2 does not interact with other important transcription factors of this tissue, and that Crx may therefore be the main actor of the Otx family in neural retina function. It also led to the discovery of a series of previously unknown partners of Otx2, which could be associated to new functions of this homeogene
Chamaillé-Jammes, Simon. "Sous le ciel africain : des fluctuations climatiques à la régulation des populations, le rôle de l'eau de surface dans la dynamique spatio-temporelle d'une populations d'éléphants." Paris 6, 2006. http://www.theses.fr/2006PA066246.
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