Статті в журналах: "Regeneration technology"

1

Zhang, Haitao, Ying Wang, Zuoqiang Liu, and Quansheng Sun. "Study on Mechanical Behavior of Aging Asphalt Based on Composite Regeneration and Modification." Advances in Materials Science and Engineering 2020 (March 16, 2020): 1–11. http://dx.doi.org/10.1155/2020/1325048.

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Although the aging asphalt and its regeneration were researched by many researchers, the poor low-temperature performance of regenerating asphalt has still not been solved yet. In this project, the composite technology of regeneration and modification will be used to solve the problem mentioned above. Through the investigation and analysis on the composite mechanism of regeneration and modification for aging asphalt, the objective of the project attempts to explore a method for the synchronized recovery of high- and low-temperature performance of aging asphalt. The research results show that the single regenerating technology cannot fully recover the low-temperature performance of aging asphalt, and the composite technology of regeneration and modification can make the performance of aging asphalt recovery well. The indexes of aging asphalt after composite regeneration and modification have been recovered, which are better than the indexes of 90# asphalt (25°C penetration is 80–100/0.1 mm) and close with the indexes of styrene-butadiene-styrene (SBS) modified asphalt. The project has demonstrated that the composite technology of regeneration and modification can make the high- and low-temperature performance of aging asphalt recovery well. The research results can obtain better economic and social benefits.

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2

Li, Junxiao, Wei Fu, and Xiaobo Yin. "Finite Element Simulation and Construction Technology Research of Cement-Emulsified Asphalt Cold Recycling System." MATEC Web of Conferences 238 (2018): 05010. http://dx.doi.org/10.1051/matecconf/201823805010.

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The force model of pavement structure is established. In order to investigate the force on pavement when the ratio and thickness of cold recycled pavement vary, three concrete pavement structures, material parameters and vehicle load parameters are designed. By finite element analysis, type 2 pavement structure make the cold-regenerative pavement structure anti-XY surface shear stress, anti-Z compressive stress and anti-Z deformation three aspects are kept in a reasonable range, and it is considered that the cold regenerative pavement structure type 2 is the best. Type 2 is specifically composed of 8 cm new asphalt surface layer +20 cm no stabilized soil regeneration base +20 cm stabilized soil regeneration base + original road soil base. The results of this paper can provide some reference for the actual design of emulsified asphalt cold regeneration construction process.

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3

Tabata, Yasuhiko. "A New Concept of Biomaterials to Induce Tissue Regeneration." Materials Science Forum 561-565 (October 2007): 1467–70. http://dx.doi.org/10.4028/www.scientific.net/msf.561-565.1467.

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A new therapeutic trial based on the self-healing potential of cells to naturally induce tissue regeneration, has been recently noted. To realize this regenerative medical therapy, it is highly required to efficiently combine cells with their local environment which basically allows cells to survive and biologically function in vivo through the essential interaction. Tissue engineering is a biomedical technology or methodology to create the local environment which promotes the proliferation and differentiation of cells to induce tissue regeneration. There are some cases where tissue regeneration can be induced only by supplying a cell scaffold of biomaterials. Drug delivery system (DDS) with biomaterials enhanced the in vivo biological activities of un-stable growth factor and gene for cell-induced tissue regeneration. The controlled release technology enabled growth factors to achieve the regeneration of various tissues experimentally and clinically. The DDS technology also augmented the biological functions of plasmid DNA and small interference RNA. The cells genetically engineered by the DDS gene system showed an enhanced therapeutic efficacy in cell-based tissue regeneration (cell-gene hybrid therapy). By making use of DDS technology, it is possible to suppress the deterioration and proceeding of chronic fibrotic diseases based on the self-healing potential inherently equipped in the living body. This paper emphasizes significance of biomaterials in tissue engineering for regenerative medical therapy.

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4

IEDA, Masaki. "Heart regeneration using reprogramming technology." Proceedings of the Japan Academy, Series B 89, no. 3 (2013): 118–28. http://dx.doi.org/10.2183/pjab.89.118.

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5

Zhang, Yue, Congjie Ou, Bihong Lin, and Jincan Chen. "The Regenerative Criteria of an Irreversible Brayton Heat Engine and its General Optimum Performance Characteristics." Journal of Energy Resources Technology 128, no. 3 (October 22, 2005): 216–22. http://dx.doi.org/10.1115/1.2213272.

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An irreversible cycle model of the Brayton heat engine is established, in which the irreversibilities resulting from the internal dissipation of the working substance in the adiabatic compression and expansion processes and the finite-rate heat transfer in the regenerative and constant-pressure processes are taken into account. The power output and efficiency of the cycle are expressed as functions of temperatures of the working substance and the heat sources, heat transfer coefficients, pressure ratio, regenerator effectiveness, and total heat transfer area including the heat transfer areas of the regenerator and other heat exchangers. The regenerative criteria are given. The power output is optimized for a given efficiency. The general optimal performance characteristics of the cycle are revealed. The optimal performance of the Brayton heat engines with and without regeneration is compared quantitatively. The advantages of using the regenerator are expounded. Some important parameters of an irreversible regenerative Brayton heat engine, such as the temperatures of the working substance at different states, pressure ratio, maximum value of the pressure ratio, regenerator effectiveness and ratios of the various heat transfer areas to the total heat transfer area of the cycle, are further optimized. The optimal relations between these parameters and the efficiency of the cycle are presented by a set of characteristic curves for some assumed compression and expansion efficiencies. The results obtained may be helpful to the comprehensive understanding of the optimal performance of the Brayton heat engines with and without regeneration and play a theoretical instructive role for the optimal design of a regenerative Brayton heat engine.

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6

Suzuki-Horiuchi, Yoko, Henning Schmitz, Carlotta Barlassina, David Eccles, Martina Sinn, Claudia Ortmeier, Sören Moritz, and Luca Gentile. "Transcription Factors Active in the Anterior Blastema of Schmidtea mediterranea." Biomolecules 11, no. 12 (November 28, 2021): 1782. http://dx.doi.org/10.3390/biom11121782.

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Regeneration, the restoration of body parts after injury, is quite widespread in the animal kingdom. Species from virtually all Phyla possess regenerative abilities. Human beings, however, are poor regenerators. Yet, the progress of knowledge and technology in the fields of bioengineering, stem cells, and regenerative biology have fostered major advancements in regenerative medical treatments, which aim to regenerate tissues and organs and restore function. Human induced pluripotent stem cells can differentiate into any cell type of the body; however, the structural and cellular complexity of the human tissues, together with the inability of our adult body to control pluripotency, require a better mechanistic understanding. Planarians, with their capacity to regenerate lost body parts thanks to the presence of adult pluripotent stem cells could help providing such an understanding. In this paper, we used a top-down approach to shortlist blastema transcription factors (TFs) active during anterior regeneration. We found 44 TFs—31 of which are novel in planarian—that are expressed in the regenerating blastema. We analyzed the function of half of them and found that they play a role in the regeneration of anterior structures, like the anterior organizer, the positional instruction muscle cells, the brain, the photoreceptor, the intestine. Our findings revealed a glimpse of the complexity of the transcriptional network governing anterior regeneration in planarians, confirming that this animal model is the perfect playground to study in vivo how pluripotency copes with adulthood.

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7

Nigmatullin, V. R. "Technology of used motor oil regeneration." Chemistry and Technology of Fuels and Oils 48, no. 1 (March 2012): 29–32. http://dx.doi.org/10.1007/s10553-012-0332-5.

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8

Tani, Shoichiro, Hiroyuki Okada, Ung-il Chung, Shinsuke Ohba, and Hironori Hojo. "The Progress of Stem Cell Technology for Skeletal Regeneration." International Journal of Molecular Sciences 22, no. 3 (January 30, 2021): 1404. http://dx.doi.org/10.3390/ijms22031404.

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Skeletal disorders, such as osteoarthritis and bone fractures, are among the major conditions that can compromise the quality of daily life of elderly individuals. To treat them, regenerative therapies using skeletal cells have been an attractive choice for patients with unmet clinical needs. Currently, there are two major strategies to prepare the cell sources. The first is to use induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs), which can recapitulate the skeletal developmental process and differentiate into various skeletal cells. Skeletal tissues are derived from three distinct origins: the neural crest, paraxial mesoderm, and lateral plate mesoderm. Thus, various protocols have been proposed to recapitulate the sequential process of skeletal development. The second strategy is to extract stem cells from skeletal tissues. In addition to mesenchymal stem/stromal cells (MSCs), multiple cell types have been identified as alternative cell sources. These cells have distinct multipotent properties allowing them to differentiate into skeletal cells and various potential applications for skeletal regeneration. In this review, we summarize state-of-the-art research in stem cell differentiation based on the understanding of embryogenic skeletal development and stem cells existing in skeletal tissues. We then discuss the potential applications of these cell types for regenerative medicine.

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9

Kaszuba, Marcin D., Paweł Widomski, Tomasz Kiełczawa, and Zbigniew Gronostajski. "The use of a measuring arm with a laser scanner for analysis and support of regenerative surfacing processes of forging dies." Welding Technology Review 92, no. 3 (April 11, 2020): 23–32. http://dx.doi.org/10.26628/wtr.v92i3.1103.

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The article presents the results of research conducted in order to develop the technology of regenerative surfacing of forging dies. The selected example shows how the use of a measuring arm with a laser scanner can be used to support the regeneration process. The tests were conducted in industrial conditions of a forging die. The analysis of the regeneration process was carried out at each of 4 stages: after wear in the forging process, after initial machining, after regenerative surfacing and after final machining. It has been shown that scanning can be used to develop programs for mechanical pre- treatment, to measure the volume of padding welds, to determine the amount of finishing allowance, to verify the effectiveness of the surfacing process and to control the quality of the die before the forging process. The obtained results confirmed the effectiveness of the regeneration carried out. In terms of performance, it has been shown that too much padding weld's material is a machining allowance. For this reason, the treatment is time and energy consuming and about 68% of the padding weld's material is waste or chips. The analysis showed the possibility of saving up to 45% of the weld metal material by using reasonable allowances of smaller thickness. These results indicate the need to modify the regeneration technology and the legitimacy of using robotic surfacing, which can provide greater precision and repeatability in the layingof padding weld’s beads. The next stage of research will be robotization of the analyzed forging die regeneration process using WAAM technology.

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10

Wang, Kun, Feng Wang, Yu Hai Guo, Hong Yan Tang, and Hua Peng Zhang. "Regeneration of the Absorbent by the PTFE Hollow Fiber Membranes Using Vacuum Membrane Regeneration Technology." Key Engineering Materials 671 (November 2015): 300–305. http://dx.doi.org/10.4028/www.scientific.net/kem.671.300.

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The polytetrafluoroethylene (PTFE) hollow fiber membranes were prepared through a cold pressing method including paste extruding, stretching and sintering in this study. Membrane vacuum regeneration technology (MVR) was developed as a novel regeneration technology for regeneration of the absorbent. The membrane structures of the PTFE hollow fiber membranes were investigated. The mixture of N-methyldiethanolamine and piperazine was selected as the absorbent. The PTFE hollow fiber membranes were used for regeneration through vacuum membrane regeneration technology. The CO2 regeneration flux and regeneration ratio increased with the increase of the regeneration temperature and the CO2 loading. The regeneration pressure was negative to the regeneration flux and regeneration ratio. When the flow rate of the rich solution increased, the regeneration ratio decreased and CO2 regeneration flux increased significantly.

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11

Yang, Dong, and Xin Du. "A review about microwave regeneration technology of waste activated carbon." IOP Conference Series: Earth and Environmental Science 983, no. 1 (February 1, 2022): 012101. http://dx.doi.org/10.1088/1755-1315/983/1/012101.

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Abstract Activated carbon (AC) can concentrate and transfer pollutants using its own adsorption capacity. Waste AC is a kind of solid waste, its adsorption capacity of pollutants is greatly reduced after adsorption saturation. If handled improperly, it will cause secondary pollution to the environment. Therefore, it is necessary to regenerate the waste AC to restore its adsorption performance and reduce environmental pollution and resource waste. Microwave regeneration technology is of great research value because of its low energy consumption, time saving and high efficiency. Based on the characteristics of microwave heating and regeneration mechanism, this paper summarizes the advantages of microwave regeneration compared with conventional heating regeneration, and the application status of microwave technology in the regeneration of waste AC was reviewed. The influence of different types of pollutants adsorbed by AC, the change of control conditions for microwave regeneration of AC and the characteristics of AC itself on microwave regeneration were briefly described. And the development direction of microwave regeneration of AC in the future is also prospected.

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12

Zhang, Cheng Hu, Na Meng, and De Xing Sun. "Anti-Blocking Technology for Urban Sewage Source Heat Pump System." Advanced Materials Research 472-475 (February 2012): 637–40. http://dx.doi.org/10.4028/www.scientific.net/amr.472-475.637.

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The extremely poor sewage quality could make the sewage heat utilization difficult. The paper introduces the content and distribution property of the sewage dirt. For the dirt properties and project experience, it proposes the two basic points of the anti-blocking technique in sewage source heat pump system: filtering surface continuous regeneration and dirt continuous reduction and the request for filtering pore size parameters. It also describes the principle of filtering surface hydraulic continuous regenerative technique and establishes its mathematical model and design method of the device. The calculation and application result indicates that filtering surface hydraulic continuous regenerative technique can guarantee the filtering effect and operation flow stable.

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13

Ma, Yuan Ze, Xiu Xia Zhang, and Rong Fan. "Study on the Preparation Technology and Regeneration Technology of Activated Carbon." Key Engineering Materials 807 (June 2019): 159–64. http://dx.doi.org/10.4028/www.scientific.net/kem.807.159.

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Due to the developed pore structure ,high specific surface area, low cost, accessible raw materials and stable physical and chemical properties, activated carbon has caused high attention of society. Nowadays activated carbon has been widely used in capacitor electrode production, water pollution treatment, medicine and other fields. We review the various preparation methods of activated carbon and analyze the advantages and disadvantages of them in this paper. The characteristics of activated carbon regeneration technology are also discussed from the perspective of improving the utilization rate of activated carbon. With the development of China's green economy and the increasing awareness of people's environmental protection, the research on the preparation and regeneration of activated carbon will surely have a broader development prospect.

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14

Wachelder, Joseph. "Regeneration: Generations remediated." Time & Society 28, no. 3 (December 2, 2016): 883–903. http://dx.doi.org/10.1177/0961463x16678253.

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This paper proposes a model for a dynamic and constructivist perspective on generations. To study synchronous, contemporary interrelations between technology, media and generations, many different methodologies are available. Yet many historical, diachronic studies are marred by flaws and ambiguities in their use of ‘generation’ as a concept. To counter those problems, this paper argues for a process-oriented approach of generations – one which is modelled after Bolter and Grusin’s remediation. By distinguishing three mechanisms – immediate generation, immediate regeneration and hypermediate regeneration – the model of regeneration is linked to three theoretical concerns: the long-standing dilemmas in the sociological study of generations, the controversy around technological determinism in technology studies and contemporary challenges in research of ageing and youth cultures. The feasibility of the regeneration approach is elucidated by applying it to toys, especially educational toys. This paper also provides a methodology for the historical study of generations interacting with media and technology by recommending the combined use of three types of biographies as source materials.

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15

Xu, Yuan. "Regeneration Aggregate Concretes Enhancement Technology Experimental Study." Applied Mechanics and Materials 193-194 (August 2012): 298–302. http://dx.doi.org/10.4028/www.scientific.net/amm.193-194.298.

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The article analyzed the filling and repairing effect of ultra-fine fly ash about recycled concrete under different gradations. And obtained something by analyzing test data: ultra-fine fly ash could improve the recycled concrete workability and strength to some extent, but different gradations of the recycled concrete have different effects on strengthen. Recycled concrete strength increased by an average of about 15% after incorporation of ultra-fine fly ash. These conclusions could provide a certain reference value for the recycled concrete research and application of enhanced technology.

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16

YOSHIZAKI, Shinji. "SPECIAL ISSUE “Coastal Environment and Regeneration Technology”." Journal of the Japanese Society of Revegetation Technology 35, no. 4 (2009): 497. http://dx.doi.org/10.7211/jjsrt.35.497.

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17

SEINO, Satoquo. "SPECIAL ISSUE “Coastal Environment and Regeneration Technology”." Journal of the Japanese Society of Revegetation Technology 35, no. 4 (2009): 498–502. http://dx.doi.org/10.7211/jjsrt.35.498.

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18

OKA, Kohei. "SPECIAL ISSUE “Coastal Environment and Regeneration Technology”." Journal of the Japanese Society of Revegetation Technology 35, no. 4 (2009): 503–7. http://dx.doi.org/10.7211/jjsrt.35.503.

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19

NOGUCHI, Hideaki. "SPECIAL ISSUE “Coastal Environment and Regeneration Technology”." Journal of the Japanese Society of Revegetation Technology 35, no. 4 (2009): 508–12. http://dx.doi.org/10.7211/jjsrt.35.508.

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KAWAI, Eiji. "SPECIAL ISSUE “Coastal Environment and Regeneration Technology”." Journal of the Japanese Society of Revegetation Technology 35, no. 4 (2009): 513–17. http://dx.doi.org/10.7211/jjsrt.35.513.

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21

TANAKA, Kenji. "SPECIAL ISSUE “Coastal Environment and Regeneration Technology”." Journal of the Japanese Society of Revegetation Technology 35, no. 4 (2009): 518–22. http://dx.doi.org/10.7211/jjsrt.35.518.

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22

Al-Farayedhi, A. A., P. Gandhidasan, and S. Younus Ahmed. "Regeneration of liquid desiccants using membrane technology." Energy Conversion and Management 40, no. 13 (September 1999): 1405–11. http://dx.doi.org/10.1016/s0196-8904(99)00036-9.

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23

Ouchi, Takehito. "iPS cell technology for periodontal tissue regeneration." Impact 2019, no. 2 (March 18, 2019): 30–32. http://dx.doi.org/10.21820/23987073.2019.2.30.

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24

Sato, Masato, Masayuki Yamato, Kosuke Hamahashi, Teruo Okano, and Joji Mochida. "Articular Cartilage Regeneration Using Cell Sheet Technology." Anatomical Record 297, no. 1 (December 2, 2013): 36–43. http://dx.doi.org/10.1002/ar.22829.

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25

Wertheim, Jason A. "Novel technology for liver regeneration and replacement." Liver Transplantation 22, S1 (October 26, 2016): 41–46. http://dx.doi.org/10.1002/lt.24635.

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26

Tabata, Yasuhiko. "Tissue regeneration based on tissue engineering technology." Congenital Anomalies 44, no. 3 (September 2004): 111–24. http://dx.doi.org/10.1111/j.1741-4520.2004.00024.x.

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27

Xiancheng, Liu, Lu Chunxi, and Shi Mingxian. "Post-riser regeneration technology in FCC unit." Petroleum Science 4, no. 2 (June 2007): 91–96. http://dx.doi.org/10.1007/bf03187448.

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28

Metcalfe, Anthony D., and Mark W. J. Ferguson. "Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration." Journal of The Royal Society Interface 4, no. 14 (December 5, 2006): 413–37. http://dx.doi.org/10.1098/rsif.2006.0179.

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Advanced therapies combating acute and chronic skin wounds are likely to be brought about using our knowledge of regenerative medicine coupled with appropriately tissue-engineered skin substitutes. At the present time, there are no models of an artificial skin that completely replicate normal uninjured skin. Natural biopolymers such as collagen and fibronectin have been investigated as potential sources of biomaterial to which cells can attach. The first generation of degradable polymers used in tissue engineering were adapted from other surgical uses and have drawbacks in terms of mechanical and degradation properties. This has led to the development of synthetic degradable gels primarily as a way to deliver cells and/or molecules in situ , the so-called smart matrix technology. Tissue or organ repair is usually accompanied by fibrotic reactions that result in the production of a scar. Certain mammalian tissues, however, have a capacity for complete regeneration without scarring; good examples include embryonic or foetal skin and the ear of the MRL/MpJ mouse. Investigations of these model systems reveal that in order to achieve such complete regeneration, the inflammatory response is altered such that the extent of fibrosis and scarring is diminished. From studies on the limited examples of mammalian regeneration, it may also be possible to exploit such models to further clarify the regenerative process. The challenge is to identify the factors and cytokines expressed during regeneration and incorporate them to create a smart matrix for use in a skin equivalent. Recent advances in the use of DNA microarray and proteomic technology are likely to aid the identification of such molecules. This, coupled with recent advances in non-viral gene delivery and stem cell technologies, may also contribute to novel approaches that would generate a skin replacement whose materials technology was based not only upon intelligent design, but also upon the molecules involved in the process of regeneration.

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Itoh, Y., J. I. Sasaki, M. Hashimoto, C. Katata, M. Hayashi, and S. Imazato. "Pulp Regeneration by 3-dimensional Dental Pulp Stem Cell Constructs." Journal of Dental Research 97, no. 10 (April 27, 2018): 1137–43. http://dx.doi.org/10.1177/0022034518772260.

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Dental pulp regeneration therapy for the pulpless tooth has attracted recent attention, and clinical trial studies are underway with the tissue engineering approach. However, there remain many concerns, including the extended period for regenerating the dental pulp. In addition, the use of scaffolds increases the risk of inflammation and infection. To establish a basic technology for novel dental pulp regenerative therapy that allows transplant of pulp-like tissue, we attempted to fabricate scaffold-free 3-dimensional (3D) cell constructs composed of dental pulp stem cells (DPSCs). Furthermore, we assessed viability of these 3D DPSC constructs for dental pulp regeneration through in vitro and in vivo studies. For the in vitro study, we obtained 3D DPSC constructs by shaping sheet-like aggregates of DPSCs with a thermoresponsive hydrogel. DPSCs within constructs remained viable even after prolonged culture; furthermore, 3D DPSC constructs possessed a self-organization ability necessary to serve as a transplant tissue. For the in vivo study, we filled the human tooth root canal with DPSC constructs and implanted it subcutaneously into immunodeficient mice. We found that pulp-like tissues with rich blood vessels were formed within the human root canal 6 wk after implantation. Histologic analyses revealed that transplanted DPSCs differentiated into odontoblast-like mineralizing cells at sites in contact with dentin; furthermore, human CD31–positive endothelial cells were found at the center of regenerated tissue. Thus, the self-organizing ability of 3D DPSC constructs was active within the pulpless root canal in vivo. In addition, blood vessel–rich pulp-like tissues can be formed with DPSCs without requiring scaffolds or growth factors. The technology established in this study allows us to prepare DPSC constructs with variable sizes and shapes; therefore, transplantation of DPSC constructs shows promise for regeneration of pulpal tissue in the pulpless tooth.

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He, San, Xiaozhuo Zhang, Xingyu Xia, Chuanjun Wang, and Sulin Xiang. "Low energy consumption electrically regenerated ion-exchange for water desalination." Water Science and Technology 82, no. 8 (September 17, 2020): 1710–19. http://dx.doi.org/10.2166/wst.2020.442.

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Abstract A new regeneration method of ion exchange resin named Adjacent Bed Electrically Regenerated Ion-exchange (ABERI) was proposed to eliminate the environmental impact of traditional chemical regeneration and improve the economy of replacing chemical regeneration with electrical regeneration. The desalting operation of ABERI was the same as the conventional mixed bed. When the resins were exhausted, anion and cation resins were separated and then packed in a dedicated regenerator adjacently. The resins were regenerated by the H+ and OH− ions produced from a pair of electrodes installed on both sides of the resin bed. By optimizing the regeneration time, current, and feed water flow rate, the energy consumption of ABERI was 0.38 kWh/m3 water; that is, 54% of that of another electrical regeneration technology, membrane-free electrodeionization (MFEDI). Compared with MFEDI, the quality and quantity of purified water produced after regeneration were improved. In ABERI, the average conductivity and the volume (times of bed volumes) of the purified water are 0.9 μS/cm and 109; that is, 75 and 133% of that of MFEDI, respectively. The preliminary economic analysis showed that ABERI offers the potential to regenerate ion exchange resin in an eco-friendly and cost-effective manner.

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Bousnaki, Maria, Anastasia Beketova, and Eleana Kontonasaki. "A Review of In Vivo and Clinical Studies Applying Scaffolds and Cell Sheet Technology for Periodontal Ligament Regeneration." Biomolecules 12, no. 3 (March 11, 2022): 435. http://dx.doi.org/10.3390/biom12030435.

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Different approaches to develop engineered scaffolds for periodontal tissues regeneration have been proposed. In this review, innovations in stem cell technology and scaffolds engineering focused primarily on Periodontal Ligament (PDL) regeneration are discussed and analyzed based on results from pre-clinical in vivo studies and clinical trials. Most of those developments include the use of polymeric materials with different patterning and surface nanotopography and printing of complex and sophisticated multiphasic composite scaffolds with different compartments to accomodate for the different periodontal tissues’ architecture. Despite the increased effort in producing these scaffolds and their undoubtable efficiency to guide and support tissue regeneration, appropriate source of cells is also needed to provide new tissue formation and various biological and mechanochemical cues from the Extraccellular Matrix (ECM) to provide biophysical stimuli for cell growth and differentiation. Cell sheet engineering is a novel promising technique that allows obtaining cells in a sheet format while preserving ECM components. The right combination of those factors has not been discovered yet and efforts are still needed to ameliorate regenerative outcomes towards the functional organisation of the developed tissues.

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Wang, Yixi, Haider Mohammed Khan, Changchun Zhou, Xiaoxia Liao, Pei Tang, Ping Song, Xingyu Gui, et al. "Apoptotic cell-derived micro/nanosized extracellular vesicles in tissue regeneration." Nanotechnology Reviews 11, no. 1 (January 1, 2022): 957–72. http://dx.doi.org/10.1515/ntrev-2022-0052.

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Abstract Extracellular vesicles (EVs), products released by cells in multiple biological activities, are currently widely accepted as functional particles and intercellular communicators. From the orthodox perspective, EVs derived from apoptotic cells (apoEVs) are responsible for cell debris clearance, while recent studies have demonstrated that apoEVs participate in tissue regeneration. However, the underlying mechanisms and particular functions in tissue regeneration promotion of apoEVs remain ambiguous. Some molecules active during apoptosis also function in tissue regeneration triggered by apoptosis, such as caspases. ApoEVs are generated in the process of apoptosis, carrying cell contents to manifest biological effects and possess biomarkers to target phagocytes. The regenerative effect of apoEVs might be due to their abilities to facilitate cell proliferation and regulate inflammation. Such regenerative effect has been observed in various tissues, including skin, bone, cardiovascular system, and kidneys. Engineered apoEVs are produced to amplify the biological benefits of apoEVs, rendering them optional for drug delivery. Meanwhile, challenges exist in thorough mechanistic exploration and standardization of production. In this review, we discussed the link between apoptosis and regeneration, current comprehension of the origination and investigation strategies of apoEVs, and mechanisms in tissue regeneration of apoEVs and their applications. Challenges and prospects are also addressed here.

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Wang, Yixi, Haider Mohammed Khan, Changchun Zhou, Xiaoxia Liao, Pei Tang, Ping Song, Xingyu Gui, et al. "Apoptotic cells derived micro/nano-sized extracellular vesicles in tissue regeneration." Nanotechnology Reviews 11, no. 1 (January 1, 2022): 1193–208. http://dx.doi.org/10.1515/ntrev-2022-0049.

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Abstract Extracellular vesicles (EVs), products released by cells in multiple biological activities, are currently widely accepted as functional particles and intercellular communicators. From the orthodox perspective, EVs derived from apoptotic cells (apoEVs) are responsible for cell debris clearance, while recent studies have demonstrated that apoEVs participate in tissue regeneration. However, the underlying mechanisms and particular functions in tissue regeneration promotion of apoEVs remain ambiguous. Some molecules, such as caspases, active during apoptosis also function in tissue regeneration triggered by apoptosis,. ApoEVs are generated in the process of apoptosis, carrying cell contents to manifest biological effects, and possessing biomarkers to target phagocytes. The regenerative effect of apoEVs might be due to their abilities to facilitate cell proliferation and regulate inflammation. Such regenerative effect has been observed in various tissues, including skin, bone, cardiovascular system, and kidney. Engineered apoEVs are produced to amplify the biological benefits of apoEVs, rendering them optional for drug delivery. Meanwhile, challenges exist in thorough mechanistic exploration and standardization of production. In this review, we discussed the link between apoptosis and regeneration, current comprehension of the origination and investigation strategies of apoEVs, and mechanisms in tissue regeneration by apoEVs and their applications. Challenges and prospects are also discussed here.

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34

Wei, Jian Guo, and Bin Wang. "PFWD's Application in the Evaluation of Structural Strength of Field Hot Regeneration Asphalt Pavement." Advanced Materials Research 723 (August 2013): 141–48. http://dx.doi.org/10.4028/www.scientific.net/amr.723.141.

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To evaluate the pre and post change of structure strength of old asphalt pavement field hot regeneration, we use the portable falling weight deflectometer method (PFWD) and benkelman beam method (BB) respectively to do the field test research. The field test researches rely on the ANXIN highway old asphalt pavement field hot regeneration project. We got the data about pre and post regenerations asphalt pavement static bending deflection (l0), PFWD dynamic deflection (lp) and PFWD dynamic modulus (EP). The correlation analysis among static bending deflection, PFWD dynamic deflection and PFWD dynamic modulus suggest that PFWD method is a more stable and reliable method than BB method and PFWD method can be a new evaluation technology for the old asphalt pavement field hot regenerations pavement strength.

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35

Kawaguchi, Nanako, Kota Hatta, and Toshio Nakanishi. "3D-Culture System for Heart Regeneration and Cardiac Medicine." BioMed Research International 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/895967.

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3D cultures have gained attention in the field of regenerative medicine for their usefulness asin vitromodel of solid tissues. Bottom-up technology to generate artificial tissues or organs is prospective and an attractive approach that will expand as the field of regenerative medicine becomes more translational. We have characterized c-kit positive cardiac stem cells after long-term cultures and established a 3D-nanoculture system using collagen scaffolds. By combining informatics-based studies, including proteomic analyses and microarrays, we sought to generate methods that modeled cardiac regeneration which can ultimately be used to build artificial hearts. Here, we describe the use of biodegradable beads or 3D cultures to study cardiac regeneration. We summarize recent work that demonstrates that, by using a combination of molecular analyses with 3D cultures, it is possible to evaluate concise mechanisms of solid tissue stem cell biology.

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36

Sanker, Subramaniam, Maria Cecilia Cirio, Laura L. Vollmer, Natasha D. Goldberg, Lee A. McDermott, Neil A. Hukriede, and Andreas Vogt. "Development of High-Content Assays for Kidney Progenitor Cell Expansion in Transgenic Zebrafish." Journal of Biomolecular Screening 18, no. 10 (July 5, 2013): 1193–202. http://dx.doi.org/10.1177/1087057113495296.

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Reactivation of genes normally expressed during organogenesis is a characteristic of kidney regeneration. Enhancing this reactivation could potentially be a therapeutic target to augment kidney regeneration. The inductive events that drive kidney organogenesis in zebrafish are similar to the initial steps in mammalian kidney organogenesis. Therefore, quantifying embryonic signals that drive zebrafish kidney development is an attractive strategy for the discovery of potential novel therapeutic modalities that accelerate kidney regeneration. The Lim1 homeobox protein, Lhx1, is a marker of kidney development that is also expressed in the regenerating kidneys after injury. Using a fluorescent Lhx1a-EGFP transgene whose phenotype faithfully recapitulates that of the endogenous protein, we developed a high-content assay for Lhx1a-EGFP expression in transgenic zebrafish embryos employing an artificial intelligence–based image analysis method termed cognition network technology (CNT). Implementation of the CNT assay on high-content readers enabled automated real-time in vivo time-course, dose-response, and variability studies in the developing embryo. The Lhx1a assay was complemented with a kidney-specific secondary CNT assay that enables direct measurements of the embryonic renal tubule cell population. The integration of fluorescent transgenic zebrafish embryos with automated imaging and artificial intelligence–based image analysis provides an in vivo analysis system for structure-activity relationship studies and de novo discovery of novel agents that augment innate regenerative processes.

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37

Liu, Jin, Jianping Ruan, Michael D. Weir, Ke Ren, Abraham Schneider, Ping Wang, Thomas W. Oates, Xiaofeng Chang, and Hockin H. K. Xu. "Periodontal Bone-Ligament-Cementum Regeneration via Scaffolds and Stem Cells." Cells 8, no. 6 (June 4, 2019): 537. http://dx.doi.org/10.3390/cells8060537.

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Periodontitis is a prevalent infectious disease worldwide, causing the damage of periodontal support tissues, which can eventually lead to tooth loss. The goal of periodontal treatment is to control the infections and reconstruct the structure and function of periodontal tissues including cementum, periodontal ligament (PDL) fibers, and bone. The regeneration of these three types of tissues, including the re-formation of the oriented PDL fibers to be attached firmly to the new cementum and alveolar bone, remains a major challenge. This article represents the first systematic review on the cutting-edge researches on the regeneration of all three types of periodontal tissues and the simultaneous regeneration of the entire bone-PDL-cementum complex, via stem cells, bio-printing, gene therapy, and layered bio-mimetic technologies. This article primarily includes bone regeneration; PDL regeneration; cementum regeneration; endogenous cell-homing and host-mobilized stem cells; 3D bio-printing and generation of the oriented PDL fibers; gene therapy-based approaches for periodontal regeneration; regenerating the bone-PDL-cementum complex via layered materials and cells. These novel developments in stem cell technology and bioactive and bio-mimetic scaffolds are highly promising to substantially enhance the periodontal regeneration including both hard and soft tissues, with applicability to other therapies in the oral and maxillofacial region.

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38

Lu, Zhao Feng, Min Qin, and Xiao Hong Guo. "A New Regeneration and Restoration Technology of Asphalt Pavement." Advanced Materials Research 150-151 (October 2010): 262–66. http://dx.doi.org/10.4028/www.scientific.net/amr.150-151.262.

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In order to defer early damages of asphalt pavement, a new regeneration and restoration technology of asphalt pavement surface is presented in preventive maintenance. The regeneration mechanism and the restoration mechanism were analyzed and the applicable conditions of the technology were proposed. Based on the application of tested road, the relevant construction technology and requirements were put forward. The results show that the new regeneration and restoration technology can better restore the surface performances of original asphalt pavement and prolong the service life of asphalt pavement；in contrast with the traditional preventive maintenance technology, it has a good economic benefit, which is worthy of making more widespread popularization and application in preventive maintenance of asphalt pavement.

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Intan Listiyana, Nidia, Yeni Rahmawati, Siti Nurkhamidah, Hafan Rofiq Syahnur, and Yusuf Zaelana. "CO2 desorption from activated DEA using membrane contactor with vacuum regeneration technology." MATEC Web of Conferences 156 (2018): 08012. http://dx.doi.org/10.1051/matecconf/201815608012.

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Carbondioxide (CO2) content in natural gas must be removed because it inhibits liquefication process of natural gas. CO2 gas separation technology using membrane contactor has been developed, however solvent regeneration using membrane contactors are still rare because it requires a larger energy. The regeneration process by using membrane vacuum technology was put forward to reduce the regeneration energy consumption. In this work, arginine, piperazine (PZ), and potassium carbonate (K2CO3) as activators were added into diethanolamine (DEA) solution to form aqueous solutions of activated DEA. The experiment of CO2 desorption from activated DEA was carried out in hollow fibre membrane contactor (HFMC). The solvent with rich CO2 at 30-70°C was flowed in the lumen of the hydrophobic polypropylene HFMC, and the shell side was maintained at a reduced pressure by a vacuum pump at 20 kPa. The effect of solvent temperature and activators were investigated to get CO2 desorption flux and regeneration efficiency. Experimental result shows that increasing of solvent temperature could enhance CO2 desorption flux and regeneration efficiency. Instead of that, the activated DEA also give better result compared with non-activated DEA. Among three activators, K2CO3 give the best result for desorption flux and regeneration efficiency.

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40

Mezzetti, B., L. Landi, H. B. Phan, I. Mantovani, S. Ruggieri, P. Rosati, and K. Y. Lim. "PROTOPLAST TECHNOLOGY AND REGENERATION STUDIES FOR RUBUS BREEDING." Acta Horticulturae, no. 505 (November 1999): 215–22. http://dx.doi.org/10.17660/actahortic.1999.505.27.

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41

Taniguchi, D., K. Matsumoto, R. Machino, Y. Takeoka, S. Oyama, T. Tetsuo, M. Moriyama, et al. "Trachea Regeneration by Bio-three-dimensional Printing Technology." Nihon Kikan Shokudoka Gakkai Kaiho 70, no. 2 (April 10, 2019): 184–86. http://dx.doi.org/10.2468/jbes.70.184.

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42

Murphy, Mary, and Frank Barry. "Cellular Chondroplasty: A New Technology for Joint Regeneration." Journal of Knee Surgery 28, no. 01 (September 30, 2014): 045–50. http://dx.doi.org/10.1055/s-0034-1390329.

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43

Kishimoto, Keiji. "Electric Power Regeneration Technology for Power-assist Bicycle." Proceedings of the Transportation and Logistics Conference 2008.17 (2008): 8. http://dx.doi.org/10.1299/jsmetld.2008.17.8.

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44

Chen, Jia-Xin, Jian-Zhong Jiang, and Xin-Yao Wang. "Research of energy regeneration technology in electric vehicle." Journal of Shanghai University (English Edition) 7, no. 2 (June 2003): 173–77. http://dx.doi.org/10.1007/s11741-003-0087-7.

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45

Layer, Paul G., and Elmar Willbold. "Regeneration of the avian retina by retinospheroid technology." Progress in Retinal and Eye Research 13, no. 1 (January 1994): 197–230. http://dx.doi.org/10.1016/1350-9462(94)90010-8.

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46

Li, Xiaoran, Zhenni Chen, Haimin Zhang, Yan Zhuang, He Shen, Yanyan Chen, Yannan Zhao, Bing Chen, Zhifeng Xiao, and Jianwu Dai. "Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine." Polymers 11, no. 2 (February 15, 2019): 341. http://dx.doi.org/10.3390/polym11020341.

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Aligned topography and biomolecular gradients exist in various native tissues and play pivotal roles in a set of biological processes. Scaffolds that recapitulate the complex structure and microenvironment show great potential in promoting tissue regeneration and repair. We begin with a discussion on the fabrication of aligned scaffolds, followed by how biomolecular gradients can be immobilized on aligned scaffolds. In particular, we emphasize how electrospinning, freeze drying, and 3D printing technology can accomplish aligned topography and biomolecular gradients flexibly and robustly. We then highlight several applications of aligned scaffolds and biomolecular gradients in regenerative medicine including nerve, tendon/ligament, and tendon/ligament-to-bone insertion regeneration. Finally, we finish with conclusions and future perspectives on the use of aligned scaffolds with biomolecular gradients in regenerative medicine.

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47

Yan, Shuiping, Mengxiang Fang, Zhen Wang, and Zhongyang Luo. "Regeneration performance of CO2-rich solvents by using membrane vacuum regeneration technology: Relationships between absorbent structure and regeneration efficiency." Applied Energy 98 (October 2012): 357–67. http://dx.doi.org/10.1016/j.apenergy.2012.03.055.

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48

Song, Pengyuan, Hansong Xiao, Baolong Wang, Wenxing Shi, Xianting Li, and Guohui Zhang. "Experimental investigation of the regeneration performance of an internally heated regenerator used for heating tower solution regeneration." Energy Conversion and Management 189 (June 2019): 184–94. http://dx.doi.org/10.1016/j.enconman.2019.03.089.

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49

Kirankumar, Shivaani, Narasimman Gurusamy, Sheeja Rajasingh, Vinoth Sigamani, Jayavardini Vasanthan, Selene G. Perales, and Johnson Rajasingh. "Modern approaches on stem cells and scaffolding technology for osteogenic differentiation and regeneration." Experimental Biology and Medicine 247, no. 5 (October 14, 2021): 433–45. http://dx.doi.org/10.1177/15353702211052927.

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The process of bone repair has always been a natural mystery. Although bones do repair themselves, supplemental treatment is required for the initiation of the self-regeneration process. Predominantly, surgical procedures are employed for bone regeneration. Recently, cell-based therapy for bone regeneration has proven to be more effective than traditional methods, as it eliminates the immune risk and painful surgeries. In clinical trials, various stem cells, especially mesenchymal stem cells, have shown to be more efficient for the treatment of several bone-related diseases, such as non-union fracture, osteogenesis imperfecta, osteosarcoma, and osteoporosis. Furthermore, the stem cells grown in a suitable three-dimensional scaffold support were found to be more efficient for osteogenesis. It has been shown that the three-dimensional bioscaffolds support and simulate an in vivo environment, which helps in differentiation of stem cells into bone cells. Bone regeneration in patients with bone disorders can be improved through modification of stem cells with several osteogenic factors or using stem cells as carriers for osteogenic factors. In this review, we focused on the various types of stem cells and scaffolds that are being used for bone regeneration. In addition, the molecular mechanisms of various transcription factors, signaling pathways that support bone regeneration and the senescence of the stem cells, which limits bone regeneration, have been discussed.

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Laurencin, Cato, and Naveen Nagiah. "Regenerative Engineering-The Convergence Quest." MRS Advances 3, no. 30 (2018): 1665–70. http://dx.doi.org/10.1557/adv.2018.56.

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ABSTRACTWe define Regenerative Engineering as a Convergence of Advanced Materials Science, Stem Cell Science, Physics, Developmental Biology, and Clinical Translation. We believe that an “un-siloed’ technology approach will be important in the future to realize grand challenges such as limb and organ regeneration. We also believe that biomaterials will play a key role in achieving overall translational goals. Through convergence of a number of technologies, with advanced materials science playing an important role, we believe the prospect of engaging future grand challenges is possible. Regenerative Engineering as a field is particularly suited for solving clinical problems that are relevant today. The paradigms utilized can be applied to the regeneration of tissue in the shoulder where tendon and muscle currently have low levels of regenerative capability, and the consequences, especially in alternative surgical solutions for massive tendon and muscle loss at the shoulder have demonstrated significant morbidity. Polymer, polymer-cell, and polymer biological factor, and polymer-physical systems can be utilized to propose a range of solutions to shoulder tissue regeneration. The approaches, possibilities, limitations and future strategies, allow for a variety of clinical solutions in musculoskeletal disease treatment.

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