Дисертації: "Regeneration technology"

1

Moxey, Steven Richard. "Regeneration in high technology marketing channels : antecedents and decision outcomes." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625134.

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High technology marketing channels face environments characterised by high levels of uncertainty and change, which create continual opportunities for regeneration by forming new business relationships and acquiring new high technology. Marketing channels are an important part of the high technology vendor marketing mix for business markets and are affected by marketing decisions made by marketing executives in the UK. To date the study of relationship exit and renewal in high technology marketing channels has not received attention in the literature and the effect of specific factors that operate in the challenging high technology environment have not been investigated. This study employs a sequential mixed methods research design with an initial qualitative phase to identify specific factors of relationship exit and renewal in high technology marketing channels. The results informed a substantial quantitative phase of telephone interviews. The sample includes small-medium business high technology marketing channels in the UK market and 512 interviews were completed, supported by Cisco Systems, IBM and Vodafone. The study extends the voice-exit theory of relationship exit to the high technology marketing channels context by considering voice-exit from relationships with both high technology vendors and high technology products. Analysis confirms cost of exit as an important antecedent of voice-exit; new antecedents are identified: market adoption benefits and compatibility. These antecedents may be specific to high technology marketing channels. The study includes preliminary testing of hypotheses on the operation of voice, based on a single item measure. Four new decision outcomes for high technology marketing channels are identified: Status Quo, Switcher, Loyal Investor and Switch Investor. Decision outcomes leading to the building of new capability based on new technology, Loyal Investor and Switch Investor are the norm in high technology marketing channels. By contrast, Switcher decision outcomes that involve purely changing vendor relationships appear to be rare. Logistic regression models are developed to quantify the relationship between the antecedent factors and the decision outcomes, identifying the variables that discriminate between decision outcomes. Managerial guidance is developed for practising high technology channel managers to help vendors influence the decision outcomes, requiring new channel marketing strategies. Finally, the evolution of high technology channels into channel networks is reviewed and methods for assessing high technology channel networks are presented.

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2

Bramhall, Naomi F. "Cochlear hair cell regeneration from neonatal mouse supporting cells." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/78149.

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Thesis (Ph. D. in Speech and hearing Bioscience and technology)--Harvard-MIT Program in Health Sciences and Technology, 2012. Cataloged from PDF version of thesis. Includes bibliographical references (p. 86-91). Unlike lower vertebrates, capable of spontaneous hair cell regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated in the immature mammalian vestibular system, the cochlea has been thought to lack any spontaneous regenerative potential. Inhibition of the Notch pathway can stimulate hair cell generation in neonatal mammals, but the specific source of these new hair cells has been unclear. Here, using in vitro lineage tracing with the supporting cell markers Sox2 and Lgr5, we show that Lgr5-positive inner pillar and 3rd Deiter's cells in gentamicin-damaged organs of Corti from neonatal mice give rise to new hair cells following treatment with a Notch inhibitor. These new hair cells are generated primarily through direct transdifferentiation of supporting cells, although a small number show evidence of proliferation. Inner pillar cells show the greatest transdifferentation capability, giving rise to immature outer hair cells, and transdifferentiating in response to damage even in the absence of Notch inhibition. In vivo pharmacologic inhibition of Notch and in vivo lineage tracing with Sox2 during genetic Notch inhibition provide generally consistent results, although additional new hair cells develop in the inner hair cell region. These data suggest a spontaneous capacity for hair cell regeneration in the neonatal mammalian cochlea. In addition, the data identify Lgr5-positive supporting cells as potential hair cell progenitors, making them an attractive target for future hair cell regeneration treatments. by Naomi F. Bramhall. Ph.D.in Speech and hearing Bioscience and technology

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3

Mishra, Chinmay. "On-Site Regeneration of Granular Activated Carbon : A literature study, comparison and assessment of different regeneration methods to find potential on-site regeneration method in Sweden." Thesis, KTH, Hållbar utveckling, miljövetenskap och teknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291272.

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In this thesis project, different existing granular activated carbon regeneration methods/technologies are assessed based on existing literature. The project aims to identify and analyse the method with the highest on-site regeneration potential by using the Himmerfjärdsverket wastewater treatment plant as a reference and performing a cost estimation analysis. Information is gathered about different methods from the literature study and then sorted into the following parts: working principle, technology readiness and cost, advantages and disadvantages, and references (case studies). The methods are then assessed and compared by a scoring and weightage system, where the factors which are regeneration efficiency, ease of implementation, sustainability, cost, and reliability are weighted and then scored for each method. Furthermore, the highest scoring method is then compared to the proposed regeneration method at Himmerfjärdsverket. The results from my comparison and assessment show that chemical regeneration is the highest scored method, followed by microwave and wet-oxidation regeneration methods. On applying chemical regeneration at Himmerfjärdsverket, it is found out that it may indeed be cheaper and more sustainable than the proposed off-site regeneration method. However, thermal and biological regeneration are better alternatives at Himmerfjärdsverket than microwave and wet- oxidation. From the above results, chemical regeneration has the highest potential for on-site regeneration of granular activated carbon in Sweden. Läkemedel i vatten är ett stort hot mot miljö och hälsa. Kommunalt avloppsvatten består av avloppsvatten från hushåll, privata och offentliga institutioner och dagvattenavrinning. En viktig läkemedelskälla i avloppsvatten är ett läkemedel som kommer in via urin och / eller avföring. Olika tekniker finns för avlägsnande av farmaceutiska rester och andra mikroföroreningar från avloppsvatten. En sådan teknik är adsorptionen av dessa rester med hjälp av Granulärt Aktivtkor (GAC). Aktivtkor (AC) är ett kolhaltigt material med liten pordiameter, stora porvolymer och hög specifik yta rea vid bearbetning. Det anses vara det bästa adsorptionsmedlet för att adsorbera organiska, oorganiska och giftiga metalljoner som finns i avloppsvattnet. Det finns två typer av aktivtkol som används för att avlägsna farmaceutiska rester: Granulärt aktivtkol och pulveriserat aktivt kol. Denna forskning syftar till att identifiera, jämföra och bedöma befintlig regenereringsteknik för att hitta den teknik som har störst potential och använda den på ett referensavloppsreningsverk. Det finns olika metoder för regenerering av använt aktivt kol (SAC). Dessa är termisk regenerering, kemisk regenerering, biologisk regenerering, elektrokemisk regenerering, mikrovågsregenerering och våt-oxidationsregenerering. Metoderna listas och förklaras med hjälp av deras arbetsprincip, beredskap, kostnad, fördelar, nackdelar och referenser till studier där de har använts. Flera kriterier / faktorer beaktas för bedömning och jämförelse av olika regenereringsmetoder. Faktorerna poängsätts sedan med hjälp av ett viktat poängsystem. Var och en av de ovannämnda faktorerna görs mellan 0–5 och tilldelas en vikt mellan 1–3. En högre poäng betyder bättre prestanda i den givna faktorn. Medan en högre vikt betyder betydelsen av faktorn. Från bedömningen visar sig kemisk regenerering vara den mest lämpliga metoden för regenerering av GAC på plats. Den minst lämpliga metoden är biologisk regenerering med en total poäng på 39. De två bästa regenereringsmetoderna på plats är kemisk och mikrovågsregenerering. I procent har kemisk regenerering och mikrovågsregenerering en rating på 93,3% och 90%. För att validera resultatet av bedömningen används Himmerfjärdsverket som referensavloppsverk. Himmerfjärdsverket bygger om och expanderar till en högteknologisk anläggning. Den nya anläggningen kommer att bestå av modern reningsteknik och hög reningskapacitet. Den planerade nya anläggningen förväntas vara klar 2025, medan byggandet påbörjades i januari 2020. I en studie genomförd av Syvab i samarbete med Ramboll, IVL och SU anges att det skulle behövas kolförbrukning på 15–20 g / m3 vatten. Den totala kostnaden per behandlat avloppsvatten skulle sannolikt öka med 20–30% till 2027 om läkemedelsreningen genomförs på Himmerfjärdsverket med hjälp av GAC och av regenereringsmetoden utanför anläggningen. Himmerfjärdsverket kommer att konsumera 3,92 ton kol dagligen eller 27,56 ton varje vecka. Detta kommer att kosta 28,7 miljoner SEK / år för 20 000 EBV (i värsta fall) och 11,5 miljoner SEK / år för 50 000 EBV. Medan kostnaden för kemisk regenerering av GAC med högsta regenereringseffektivitet uppskattas till 27,4 miljoner SEK / år för användning av flytande NaOH-lösning och 17,7 miljoner SEK / år för användning av fast NaOH för 20 000 EBV. För mängden 573 t / år kol kommer NaOH-förbrukningen att vara 2083,5 t / år, vilket kommer att kosta 7,1 och 10,9 miljoner SEK / år för 50 000 EBV. Eftersom kostnad är en av de viktigaste faktorerna som motverkar tillämpningen av metoder som är lika tillförlitliga som termisk regenerering. Om termisk regenerering implementeras på Himmerfjärdsverket kan installationen användas för att regenerera GAC från andra reningsverk från Stockholm. 2 GAC-bio filter i serieskapare bättre förutsättningar för biologisk regenerering av GAC samt ger låga föroreningskoncentrationer och höga syrekoncentrationer. För att lägga till det producerar Himmerfjärdsverket biogas som kan användas för att uppnå höga temperaturer som krävs enligt denna metod eller generera den erforderliga elen eller båda. I alla tre fall kommer kostnaden att minskas ytterligare. Avslutningsvis har kemisk regenerering den högsta regenereringspotentialen på plats bland alla andra studerade metoder. Medan termisk regenerering är nära den andra på grund av kolförlusten. En pilotstudie krävs för att validera de regenereringseffektivitet som nämns i litteraturen och bearbetningsförhållandena och typerna av adsorbera vid Himmerfjärdsverket behöver utvärderas liksom behandlingsförhållandena.

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4

Zhang, Zhifen. "Use of genetic transformation technology in oil crops: soybean and sunflower." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462871872.

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5

Sarver, Emily Allyn. "The Ferrous Regeneration Process for Use in Alternate Anode Reaction Technology in Copper Hydrometallurgy." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/34291.

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The Fe(II) regeneration process is an important aspect of Alternate Anode Reaction Technology (AART) using Fe(II)/Fe(III)-SO2 reactions for copper hydrometallurgy; however little has been done to study it specifically. The process regenerates Fe(II) via Fe(III) reduction by SO2(aq), catalyzed by activated carbon particles. To better understand and improve the process, two studies have been conducted with respect to variable factors and their affects on the regeneration. A study of fundamental kinetics confirms that the regeneration reaction is mass transfer-controlled, requiring adsorption of reactants onto the catalyst surface for reaction. The reaction rate is limited by the diffusivity of Fe(III). Initial Fe(III) concentration and carbon particle size are determined to be the most influential factors on the rate under the condition studied. Furthermore, it is observed that flow rate may inhibit the reaction by reducing ion diffusivity. A rate expression for the regeneration is derived and experimentally validated, and the Fe(III) diffusivity is determined to be 1.1x10-7 cm2/s. An optimization problem is also developed and solved for the process, constrained by the requirement that negligible SO2 could be present in the process effluent. Before optimization, a relationship is developed between regeneration rate and variable factors. Again, carbon size and initial Fe(III) are the most influential factors on the regeneration rate, related to it linearly; temperature is significant with a squared relationship to the rate; initial SO2 is insignificant. Optimal conditions are found with minimum carbon particle size, maximum initial Fe(III) concentration, and moderate temperature. Master of Science

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6

Okamoto, Satoshi. "Investigation of retinal regeneration by cell therapy with the induced pluripotent stem cell technology." Kyoto University, 2013. http://hdl.handle.net/2433/175084.

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7

Prina, Elisabetta. "Recreating 3D limbal architectures by two-photon polymerization for cornea regeneration." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49875/.

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Limbal Epithelial Crypts (LECs) are stem cell niches located in the limbus, the area between the cornea and the conjunctiva, and are responsible for cornea epithelium regeneration. Their anatomical structures were identified and described by Dua et al (2005). Stem cells migrate from this area toward the cornea where they differentiate into corneal epithelial cells. The lack of the LECs determines a pathology called Limbal Stem Cell Deficiency (LSCD) that can cause conjunctivalization, neovascularisation, corneal opacification, eventually resulting in vision loss. Currently, the main carriers to support limbal stem cell proliferation and differentiation used in clinics do not include enclosed structures able to act as cell reservoirs. In addition, the driving forces that determine the migration and the differentiation of limbal stem cells are not clarified yet. The hypotheses of this thesis were that the stiffness and the geometry of the scaffold influence the limbal stem cell differentiation process. Understanding these key factors could help to inform the design of scaffolds for future cornea regeneration strategies. The effect of the stiffness on cell differentiation is a well-known mechanism, but is less investigated in the limbus-corneal tissue. In this work, it was studied by producing macro-scaffolds (d=8 mm) obtained by UV-crosslinking. The stiffness was varied by increasing the concentration of Gelatin Methacrylate (GelMA), a biocompatible, photocrosslinkable material. Compression tests, rheology, AFM, and swelling analysis were performed on the developed hydrogels and compared to the ex vivo human cornea values. The gels with a concentration between 5% and 15% (w/v) exhibited mechanical properties in the same order of magnitude obtained for the cornea. The results indicated that the increased stiffness did not have a significant impact either in the expression of cytokeratin (CK3/CK14, stem cell marker, and CK14, differentiation marker), or in the gene expression (KRT3 and KRT19). However, the secondary key factors explored, differentiation media and oxygen concentration, supported cell differentiation. Inkjet printing was investigated as an additive manufacturing technique to produce 3D architectures. Although with this technique it was possible to develop a 3D structure with a stiffness gradient, its resolution was not sufficiently high to obtain a structure with dimensions comparable to the in vivo limbal stem cell niche. The second hypothesis was verified by developing a biocompatible scaffold mimicking the structure of the limbal stem cell niche and by evaluating the impact of its architecture on stem cell differentiation. The crypt geometry was modelled as U-shaped scaffolds with a diameter narrowing from 200 μm to 20 μm and was micro-fabricated from GelMA/PEGDA-based hydrogels using a Two-Photon Polymerization system (2PP). However, it was proven that the use of riboflavin as photoinitiator was inefficient at 780 nm, the wavelength used in the 2PP system. For this reason, P2CK was used as photoinitator to obtain stable hydrogels. The 2PP system allowed the precise recreation of the exact dimensions of the native crypts. Swelling, susceptibility to enzymatic degradation and stiffness were all evaluated. The biocompatibility of the printed scaffolds was assessed using immortalized human corneal epithelial cell proliferation up to 14 days. The ability of limbal stem cells to repopulate the crypts was demonstrated via two strategies. In the first strategy, human limbal stem cells were seeded directly inside the niche whilst in the second strategy, primary human limbal explants were placed adjacent to the printed structures and cells migrated towards the scaffold. Cell distribution and differentiation along the z-axis were evaluated using confocal microscopy. Cytokeratin 14 (CK14) with p63 and Cytokeratin CK3/12 (CK3/12) were used as limbal stem cell and differentiated corneal epithelial cell markers, respectively. Limbal epithelial stem cells were cultured in two conditions: xeno-free media, and with primary cells in serum containing media on a feeder layer. Both conditions showed the zonation of markers along the z-axis, which was not observed on flat scaffolds, demonstrating that the geometry alone influences cell phenotype. This suggests that the enclosed geometry results in the generation of a microenvironment inside the niche that influences cell phenotype. The presence of soluble factors, generated by cellular secretions, a specific oxygen concentration, and a more ‘stressful’ biomechanical milieu for the cells are some hypotheses that need further investigation and will be the basis of future work. In conclusion, the hypotheses of this thesis were partially confirmed. The variation in gel stiffness did not allow for the control of the hLESC differentiation process. However, the results demonstrated the influence of the geometry on stem cell differentiation without the use of signaling molecules. Further studies are necessary to have a description of the detailed spatial variability of the scaffold’s characteristics. Overall, the 2PP approach is flexible and could be applied to the generation of stem cell niches of other tissues, and could represent a significant advance in regenerative medicine.

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8

Pound, Jodie Claire. "Strategies for cartilage regeneration : use of human mesenchymal stem cells, alginate microcapsules and bioreactor technology." Thesis, University of Southampton, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440411.

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9

Viswanath, Aiswarya. "Dental stem cell delivery through new injectable matrices for spinal cord regeneration." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/47606/.

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Traumatic spinal cord injury (SCI) is a global health problem involving complex pathophysiological cascade and afflicts both developing and developed countries. Transplantation of Mesenchymal stem cell population such as dental stem cells (DSC) have demonstrated preclinical potential for central nervous system (CNS) repair. The work presented in this thesis has evaluated the potential of dental stem cells from apical papillae (SCAP) in combination with different biomaterials for SCI repair. ECM scaffolds were produced from different mammalian tissues including spinal cord, bone and dental hard tissue using different decellularisation processes. Scaffolds were then digested with pepsin to allow solubilisation and hydrogel formation. The ECM hydrogels were characterised and embedded with SCAP to investigate the effect of morphological and biochemical properties upon cell characteristics. All the hydrogels maintained high cell viability and an increase in the cell number with a satisfactory metabolic activity. However, only ECM hydrogels from decellularised spinal cord and bone tissue supported the expression of neural lineage and pro angiogenic markers with stronger responses observed with spinal cord ECM hydrogels. Biodegradable PLGA-Triblock (PLGA-TB) microparticles were fabricated to provide controlled release of glial cell derived neurotrophic factor (GDNF) and may facilitate SCAP attachment. An optimal PLGA-TB microparticle formulation was selected based on the size, surface morphology and release profile achieved. All commercial preparation of GDNF being stabilised in salt, a modified protocol was required to prepare microparticles. The formulation was modified with 10mM sodium acetate which led to a successful encapsulation and sustained release of bioactive GDNF. To support SCAP attachment and survival, PLGA-TB microparticles surfaces were coated with different ECM pre-gel solutions (spinal cord and bone tissue ECM) and laminin. Assessment of surface coating with ToF-SIMS showed protein adsorption on all the coated microparticles, with a higher adsorption on ECM pre-gel coated microparticles. All the surface modified PLGA-TB microparticles supported prolonged SCAP attachment and survival. Laminin and bone ECM pre-gel coated microparticles promoted a significant increase in SCAP number after 7 days. Over all, the result in this thesis have shown that SCAP combined with decellularised mammalian tissue derived ECM hydrogels or GDNF loaded PLGA-TB microparticles may facilitate delivery of autologous stem cells to promote spinal cord repair.

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10

Breinan, Howard Alan 1968. "Development of a collagen-glycosaminoglycan analog of extracellular matrix to facilitate articular cartilage regeneration." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/49641.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1998. Includes bibliographical references (leaves 205-220). by Howard Alan Breinan. Ph.D.

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11

Burman, Gustav. "Evaluation of carbon regeneration kiln : Comparison of different kiln types using simulation software." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175613.

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Energy efficiency calculations and an economical analysis has been conducted on two different carbon regeneration kiln types. The purpose was do determine what economical winnings there could be by replacing the carbon regeneration system using propane burner with one heated by electricity. This project was conducted on a carbon regeneration kiln that stands at the G1A processing plant in Boliden. The two different heating solutions were implemented in the multiphysics software Comsol to determine their energy efficiency’s, and then an economical analysis was conducted by comparing the annual consumption of energy per kiln type. The models were built to be as accurate as possible, but some simplifications had to be made to make the simulations possible. The results from the study showed that the electrical heating solution was over four times more energy efficient, which would lead to an annual saving of 745 714 SEK/year. The results of this simulation must however be considered somewhat inconclusive due to implementation difficulties, but it might serve as a good predictor as to why electrical heating panels could be economically feasible.

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12

Clayton, Jane. "The art of regeneration : the establishment and development of the Foundation for Art and Creative Technology, 1985-2010." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/8413/.

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This thesis is about change. It is about the way that art organisations have increasingly been used in the regeneration of the physical environment and the rejuvenation of local communities, and the impact that this has had on contemporary society. This historical analysis of the development of a young art organisation, the Foundation for Art and Creative Technology (FACT), which has previously not been studied in depth, provides an original contribution to knowledge with regard to art and culture, and more specifically the development of media and community art practices, in Britain. The nature of FACT’s development is assessed in the context of the political, socio-economic and cultural environment of its host city, Liverpool, and the organisation is placed within broader discourses on art practice, cultural policy, and regeneration. The questions that are addressed – of local responsibility, government funding and institutionalisation – are essential to an understanding of the role that publicly funded organisations play within the institutional framework of society, without which the analysis of the influence of the state on our cultural identity cannot be achieved. The research was conducted through the triangulation of qualitative research methods including participant observation, in-depth interviews and original archival research, and the findings have been used to build upon the foundations of the historical analysis and critical examination of existing literature in the fields of regeneration and culture, art and media, and museum theory and practice. This research concludes that FACT, in its establishment and development, has been heavily influenced by the unique local conditions of Liverpool, and by wider national policy, and it asserts that the organisation’s growth was aided by its location in a city that was in receipt of increasing levels of financial support after the social unrest of the early-1980s, throughout New Labour’s policies of ‘social inclusion,’ and following the award of European Capital of Culture status in 2003. Intrinsically linked to these funding opportunities was the process of institutionalisation that FACT has undergone, and the rebranding of the organisation in 1997 and opening of the FACT Centre in 2003 are cited as the main reasons for the redefinition of the organisation’s aims and objectives. These claims are supported by the interrogation of the Video Positive festivals, the Collaboration Programme and the Moving Image Touring and Exhibitions Service, sub-brands which comprised FACT’s core offer prior to the opening of the FACT Centre. The changes that have taken place within each of these projects is identified as symptomatic of the power of national funding and government policy, the changing technological environment and the production and consumption of art.

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Owusu-Agyeman, Isaac. "Systems for ammonium concentration for further removal in the partial nitritation/anammox technology." Thesis, KTH, VA-teknik, Vatten, Avlopp och Avfall, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-99356.

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Anammox is one of the main processes discovered quite recently for removal of ammonium from wastewater. Anammox process is cost effective, in that low energy and carbon source is needed. Partial nitritation is a perquisite for anammox in wastewater treatment for removal nitrogen and therefore partial nitritation/Anammox technology is studied substantially and applied in full-scale. However, the technology at present can only be used to treat high rich ammonium streams. Application of Anammox for treatment of low ammonium wastewater is not possible because of low yield of Anammox bacteria. The study aimed at devising strategies for using the Anammox technology to treat wastewater streams with low concentration of ammonium nitrogen. The objective was to get systems that could concentrate ammonium from low ammonium waste streams, so as to be able to treat it with partial nitritation/Anammox process. Two methods were used to concentrate ammonium: ion exchange and reverse osmosis. Ion exchange method was used to concentrate UASB effluents of about 24 - 40 mg NH4-N/l to 188 - 367 mg NH4-N/l respectively which is about 9 times the initial concentrations. At VRF 5, 163 mg NH4-N/l concentrate was attained from 41.8 mg NH4-N/l RO feed. Results also showed that concentrates from both methods are able to be treated with partial nitritation/Anammox technology. However it took more than 32 hours to complete treatment of ion exchange concentrates while it took less than 24 hours to finish the partial nitritation/Anammox process of RO concentrates. The longer time taken can be attributed to high salinity of the concentrates which is as a result of NaCl which was used for regeneration in ion exchange process. Both ion exchange and reverse osmosis are viable methods for concentrating ammonium from UASB effluents. Dissolved oxygen was very important factor that influenced the biological process.

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Tabarizadeh, Elham. "PDMS-based membranes for dehydration of Triethylene glycol using pervaporation technology." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.

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This thesis is relying on membrane separation technology and it seeks to find an appropriate membrane to use in pervaporation setup for the subsea regeneration of triethylene glycol (TEG) in natural gas dehydration. Although some effort have been spent on membrane absorption for gas dehydration with glycols, there is still a lack of information about TEG dehydration using pervaporation technology with different membranes, therefore experimental data is needed to assess the feasibility of using membrane pervaporation for regeneration of TEG for subsea condition. In the present work, an experimental study of dehydration of TEG with pervaporation technology has been carried out using a composite membrane with the porous support of polysulfone (PSF) coated with a dense layer of Polydimethylsiloxane (PDMS). The membrane was characterized in terms of compatibility to TEG, chemical analysis identification using Fourier Transform Infrared (FTIR) spectroscopy, morphology and surface properties with scanning electron microscopy (SEM), and contact angle measurements. Furthermore, a method for analyzing low concentrations of TEG in aqueous solutions was used with gas chromatography (GC) as this was vital to the pervaporation study. The criteria for choosing PDMS polymer was the minimum TEG uptake, high flux, and lower price.

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Gruber, Stacey M. S. "A Platform Technology for Concurrent 3D Printing of Decellularized Matrices and Polycaprolactone for Regeneration in Homogenous and Heterogeneous Tissues." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595850037389807.

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16

Abu, Awwad Hosam Al-Deen. "Controlled release system for delivery of GET peptide and its application for transcription factor delivery for bone regeneration." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50996/.

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The repair of bone defects and non-union fractures is a significant challenge for clinicians as it requires tissue replacement. The current graft approaches used to treat these injuries have limitations with regard to quality and availability. This has resulted in research efforts to develop alternative synthetic materials that are able to aid tissue regeneration. These materials usually combined with biological factors to induce cells proliferation and differentiation. Transcription factors can provide specific regulatory effect, however, these transcription factors are very difficult to be delivered intracellularly. A recent work, conducted at Tissue Engineering group – University of Nottingham, has shown that recombinant transcription factors can be expressed, purified and delivered efficiently to control cell behaviour for further tissue engineering applications. Efficient delivery of these factors can be achieved by using Glycosaminoglycan-binding enhanced transduction (GET) peptides, which are multi-domain peptides comprising a GAG-binding peptide (to promote cell interaction) and a cell-penetrating peptide (CPP) for high efficiency membrane transduction. The aim of the work presented in this thesis was to develop a poly-(lactic-co-glycolic acid) (PLGA) based delivery system to release RUNX2 transcription factor, which is significantly involved in osteogenesis. GET peptide was utilised to enhance the intracellular delivery of RUNX2. The advantage of this system is to control the dose and localisation of the released RUNX2 as well as providing a biodegradable scaffold to support the newly formed tissue. Reproducible procedures were developed to manufacture spherical PLGA microparticles (MPs) using Solid-in-oil-in-water (S/O/W) emulsion method. Red florescent protein (RFP) coupled with GET peptide was used as model protein to evaluate the stability of peptide during microparticles fabrication and release. Efficient encapsulation (~65%) and tailored protein release profiles could be achieved, however intracellular transduction was significantly inhibited post-release. Co-encapsulation of L-Histidine, which may form a complex with the PLGA degradation products under acidic conditions, was used as a strategy to retain GET peptide activity. Simulations of the polymer microclimate showed that hydrolytic acidic PLGA degradation products directly inhibited GET peptide transduction activity, use of L-Histidine significantly enhanced released protein delivery. GET-RUNX2 was efficiently encapsulated (~60%) within PLGA MPs using the developed S/O/W method and release profile was adopted to match the optimal RUNX2 dose needed to induce osteogenesis of hMSCs (i.e. 60μg in the first 7 days of the study). GET-RUNX2 activity post release was evaluated. Results showed comparable transduction and transfection activities (compared to experimental control) throughout the release period. GET-RUNX2 loaded MPs were mixed with temperature-sensitive PLGA/PEG particles to provide scaffold structures. hMSCs were used for an in-vitro differentiation assessments. Osteogenesis gene markers were comparable to experimental controls for both early and late markers. Moreover, the scaffold formula was optimised to be 3D printable to provide complex and irregular shape scaffolds matching defect size. The ability to control intracellular transduction of functional proteins into cells will facilitate localised delivery of therapeutics, with minimised risk of systemic dosing that may lead to non-targeted activity, and allow approaches to direct cellular behaviour for regenerative medicine applications.

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17

Wattam, E. N. "Integrating social media for community empowerment : a study of community reporting in two Greater Manchester urban regeneration areas." Thesis, University of Salford, 2013. http://usir.salford.ac.uk/29486/.

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Despite an unshakable belief in the UK in the empowering and regenerating potential of ICTs locating the benefits of digital inclusion initiatives for deprived urban communities has remained elusive. Given social media discourses of empowerment and social progress this thesis explores whether and how social media may be associated with a greater potential for community empowerment and regeneration. I specifically focus upon the potential of the relationship between participation in community content creation and sharing, (community generated content), community empowerment and regeneration. The exploration is based on a qualitative case study of a Community Reporter Programme with a social media and empowerment focus being integrated within two urban regeneration areas in Greater Manchester. The study draws primarily on the experiences and insights of community reporter participants. The way in which participation in community generated content becomes meaningful within urban regeneration areas and thus potentially empowering, is found to lie in a complex interweave of individual interpretative framing, aspects of identity beyond the demographic frame and strategies for the domestication of the specific social media practice of community reporting. The study finds that empowerment value attached to participation in community generated content is primarily located at the individual level and psychological and social in nature related to a ‘reconnecting’ and ‘feel good’ factor which appears to have a particular benefit for those who have been at risk of social exclusion. The value at the collective level of empowerment constructed as ‘voice’ is found to be limited and potentially disempowering within a social context of audience inattention and subtle dangers of ‘voice’ exploitation and appropriation. The study highlights fresh perspectives on what ICTs might mean for local communities beyond the established links between online and offline social interaction and social capital frame locating empowerment value specifically in the process of social media focused content production. In line with emergent critiques of participatory culture the study also problematises assumptions of ease of participation and voice attached to social media technologies. While the study supports the emergent view within digital inclusion and community informatics research areas that the empowerment value of ICTs may indeed lie in the arena of content production, the importance of viewing the potential through a critical lens of specific co-creative media practices and shining a light on urban regeneration as a potential arena of disempowerment is identified.

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Kubilius, Tomas. "Žėlimas juodalksnynuose ir jį lemiantys veiksniai." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090615_115016-00404.

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Darbo tikslas – Ištirti žėlimo intensyvumą juodalksnynuose ir kokybę lemiančius veiksnius. Darbo uždaviniai – Ištirti žėlimo intensyvumą juodalksnynuose nuo motinio medyno amžiaus, nuo augavietės ir buvusio medyno rūšinės sudėties. Nustatyti žėlimo intensyvumą nuo kirtimui naudotos technologijos. Darbo objektas – Kazlų rūdos mokomosios miškų urėdijos Bagotosios girininkijos juodalksnynai. Darbo metodai – Tyrimui buvo atrinkta 18 juodalksnio biržių, nukirstų 1996-2006 metais. Parenkant kirtavietes, buvo atsižvelgta į tai, kad būtų skirtingos kirtimų technologijos, kad būtų įvairesnėse augavietėse, kad būtų įvairesnė rūšinė sudėtis, bet jose vyrautu juodalksnis. Atrinktuose plotuose buvo uždėtos apskaitos aikštelės, kuriuose siekiant nustatyti juodalksnio žėlimo intensyvumą, buvo atlikti tyrimai: aprašyta ploto charakteristika, nustatytas atauginių ir sėklinių juodalksnio savaiminukų, tame skaičiuje gyvybingų skaičius, kitų medžių rūšių savaiminukų skaičius, išmatuotas aukštesnių medelių aukštis ir storis. Apdorojant tyrimų duomenis, kiekvienam plotui nustatyta atauginio ir sėklinio juodalksnio žėlimo kokybė ir intensyvumas. Pagal miško atkūrimo ir įveisimo nuostatus įvertinta juodalksnio jaunuolynų būklė ir žėlinių kokybė. Darbo rezultatai – Kas met šalyje plynai iškertama šimtai hektarų juodalksnynų. 87% visų nukirstų juodalksnio kirtaviečių paliekamos žėlimui. Biržės sėkmingai želdosi tada, kai medynai kertami žiemą, kertama sėkliniais metais, kirtavietėse paliekami geri iš... [toliau žr. visą tekstą] Goal of study – to find the reason of natural regeneration of black alders forests. Task of study – To find the intensity of the regeneration of black alders and to indentify how much does it depends on the main sort, age and the area. To find the intensity of the regeneration which depends on cutting technology Object of study – Black alders forests in Kazlu Rudas ferestry enterprice. Methods of study – There was 18 different areas of blac alders forests cutted in 1996-2006. For the researc of the areas there were been looking for the different technologies of the cutting, with a different forests, but most of all of black alders. In that areas were made special places of the counting, there were done these types of analysis: describtion of the area, counting of the natural regeneration of black alders, regeneration of another type of trees, intensity and the quality of the regeneration of black alders. Made a report of the condition and the quality of a young black alders forests. Results of study– There were cutted hundreds of hectares of black alders forests each year. About 87% of all cutted black alders areas were left to generate. The cutted areas are sucsesfully regenerating if they were cutted in winter time, and the year of the seeding. It is very important to leave the goog quality trees which had grown from the seeds. In the areas there were cutted using the footstalk technology the regeneration of black alders forests was good. In the most of all areas there... [to full text]

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Tomko, Jonathan E. "The Social Future of Small Town America." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535459044034816.

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20

Гринь, Григорий Иванович, Евгений Александрович Семенов та Павел Анатольевич Козуб. "Разработка технологии регенерации марганца и никеля из растворов их солей". Thesis, Черкаський державний технологічний університет, 2004. http://repository.kpi.kharkov.ua/handle/KhPI-Press/30250.

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Предложена технологическая схема утилизации хлоридов марганца и никеля из водных растворов. Предлагаемая технологическая схема характеризуется замкнутостью по твердым, жидким и газообразным веществам, практически полным отсутствием отходов. A technological scheme for the utilization of manganese and nickel chlorides from aqueous solutions is proposed. The offered technological scheme is characterized by closedness on solid, liquid and gaseous substances, practically complete absence of waste.

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21

Webber, Nicholas R. "Technology and Commercial Assessment of a Tissue Regenerating Drug in the Regenerative Medicine Market." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1402249985.

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22

Larroque, Joël. "Etude, conception et realisation d'un demodulateur a remodulation quadriphase : application a la regeneration du signal dans les satellites de telecommunications ou de relais de donnees." Toulouse 3, 1988. http://www.theses.fr/1988TOU30087.

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Ce memoire presente l'etude d'un demolutateur a remodulation quadriphase a la frequence de b, 87 ghz permettant la regeneration des signaux hyperfrequence a bord des satellites de telecommunications (a acces multiples commutes a bord) ou de relais de donnees (pour les liaisons avec des satellites ou des navettes en orbite basse ainsi qu'avec des mobiles terrestres. Le demodulateur a remodulation quadriphase est compose de sous-equipements dont une simulation permet de connaitre leurs influences sur les performances du systeme complet

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23

Ferrand, Alice. "Développement de biomatériaux nanofibreux/microporeux actifs pour la régénération osseuse." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAE030.

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Les nanotechnologies sont en train de révolutionner le domaine biomédical et plus particulièrement l’ingénierie tissulaire. Elles permettent aujourd’hui, non seulement de réparer mais aussi de régénérer les tissus. Cette nanomédecine régénérative est particulièrement adaptée pour répondre aux besoins importants liés aux maladies dégénératives, au vieillissement et aux traumatismes.Mon travail de thèse s’inscrit dans ce contexte et concerne l’élaboration de biomatériaux nanofibreux et microporeux actifs pour la régénération osseuse. Notre objectif essentiel est de réaliser un implant biodégradable nanostructuré permettant d’accélérer la réparation du tissu osseux. Notre stratégie innovante repose non seulement sur la mise en oeuvre de membranes par électrospinning mais aussi sur leur fonctionnalisation par des facteurs de croissance. Cette fonctionnalisation originale a consisté à enrober ces principes actifs dans des nanoréservoirs en utilisant la technique multicouche de polyélectrolytes. Des membranes de polycaprolactone (PCL) nanofibreuses et microporeuses ont été obtenues par électrospinning puis les fibres ont été enrobées de réservoirs contenant le facteur ostéoinducteur, la protéine morphogénique osseuse 2 (BMP-2). L’induction osseuse engendrée par ces réservoirs actifs a été mise en évidence in vitro après culture d’ostéoblastes humains primaires. Des expérimentations in vivo chez la souris ont permis de confirmer l’accélération de la régénération osseuse grâce à ces nanoréservoirs.Cette même stratégie a été validée in vivo, chez la souris, en utilisant des membranes de collagène d’origine animal commerciales utilisées en clinique. L’activité de ces membranes fonctionnalisées par des nanoréservoirs de BMP-2 est en cours d’analyse dans le cadre de tests précliniques pour une application maxillofaciale et parodontale Nanobiotechnology enables the emergence of entirely new classes of bioactive devices intended for targeted intracellular delivery for more efficiency and less toxicities. Tissue engineering is an interdisciplinary field that has attempted to implement a variety of processing methods for synthetic and natural polymers to fabricate tissue and organ regeneration scaffolds.We report here the first demonstration of bone regeneration by using a strategy based on a synthetic nanostructured membrane. This electrospun membrane is manufactured by using a FDA approved polymer, PCL, (polycaprolactone), and functionalized with nanoreservoirs of a growth factor (BMP-2). Our expected outcomes are the development of clinical applications in the field of tissue engineering and nanomedecine and particularly in bone regeneration.We propose the development of smart nanostructured active implants for regenerative medicine. Our strategycombines a synthetic biodegradable electrospun nanofibrous membrane based on PCL and a bioactive growth factor (BMP-2) entrapped into polymer nanoreservoirs built atop the nanofibers according to the layer-by-layer technology. In this study, by using primary osteoblasts, we have shown the capacity of these sophisticated implants to promote and accelerate not only in vitro bone induction; but also, in vivo, bone formation (mouse model).We have also validated our strategy, in vivo (mouse model), by using an already used in the clinic collagen membrane (animal origin) to accelerate bone regeneration. This unique strategy is used to entrap, protect and stabilize the therapeutic agent into polymer coating acting as nanoreservoirs enrobing fibers of membranes

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Thorman, Nanny, and Mimmi Grahn. "En studie om regenerativ bomullsodling : Är regenerativt jordbruk nästa steg i utvecklingen av ekologisk bomullsodling?" Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-26451.

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Att uppnå de globala målen är av vikt för en hållbar utveckling. Odugliga jordbruksmetoder utgör en stor del av de klimathot som planeten i stunden utsätts för. Det är av intresse att undersöka vilka hållbarhetsvinster som kan erhållas vid regenerativ bomull samt definiera begreppet. Regenerativ bomull definieras utifrån det faktum att bomullen är odlad i enlighet med regenerativa jordbruksmetoder. De regenerativa jordbruksmetoderna är således både en inställning samt praxis. Metodens fokus är att bevara samt förbättra planetens jordhälsa. En frisk jord bidrar till att biologisk mångfald, kolinlagring samt fotosyntesens fortgång ökar. Konventionella metoder vid bomullsproduktionen bidrar till att jorden utarmas vilket leder till en försvagad biologisk mångfald och drastiska klimatförändringar. I den konventionella andelen bomull ingår även BCI-certifierad bomull vilken anses som något bättre i jämförelse då den innefattar principer som skall gynna den hållbara utvecklingen. Det är dock enbart initiativ till förbättring som uppmanas och inga faktiska krav ställs. Ekologiskt odlad bomull genomförs enligt den odlingsmetod som ställer mer miljövänliga krav men den globala andelen utgörs enbart av 1%. För att sammanställa litteraturstudien har en bred informationsinsamling genomförts innehållande bland annat bomull, certifieringar, jordbruk, regenerativa jordbruksmetoder samt klimatpåverkan vid dåligt utfört jordbruk. Studien tar hänsyn till ekologiska, sociala samt ekonomiska hållbarhetsaspekter och resultatet återspeglas i en sammanställd tabell där de olika jordbruksmetodernas skillnader ställs mot varandra. Slutsatsen belyser att det finns svårigheter med att få jordbrukare att konvertera till de regenerativa jordbruksmetoderna. Svårigheterna ligger bland annat i de likheter på krav som ställs vid omställning till ekologiskt jordbruk. Då denna ej har uppgått till en procentuellt större andel globalt blir det svårt att inom tidsramen för Agenda 2030 få regenerativa odlingsmetoder att lyfta. Däremot är den regenerativa odlingsmetodens krav essentiella och tillsammans utgör de en del av lösningen på världens klimatproblem. Det regenerativa jordbruket har potential att bidra till hållbarhetsvinster genom att bland annat öka kolinlagringen i jorden och motverka klimathoten. En omställning i jordbrukspraxis som gynnar hållbar utveckling är av yttersta vikt. Poor farming practices have a major impact on the environment. The current cotton production is environmentally unsustainable and to achieve the global goals, it is necessary to call for action. Included in the conventional grown cotton is BCI-cotton, these methods aim for a more environmentally friendly approach for farmers but does not include any requirements. Organically grown cotton sets certain requirements, but it does not exceed 1% globally. It is therefore of interest to investigate if regenerative cotton can obtain any sustainable profits. It is also of interest to define the concept of regenerative cotton. It is concluded that regenerative cotton is rather regenerative agriculture, and this is both an attitude and a suite of practices. The practical methods are based on the same biological components that create and maintain life on the planet. The utmost importance lies in the health of the soil. Healthy soil contributes to positive aspects including increased photosynthesis, storing carbon, and biodiversity. The literature study has been conducted to assemble information about cotton, organic certifications, regenerative farming practices, and environmental losses due to poor agriculture. The result is presented as a table which includes a comparison between the different agricultural practices and both ecological, social, and economic aspects are considered to the sustainable development. The major difficulties of converting to regenerative cotton lies in the similarities to convert to organic. It will be challenging for farmers due to the lack of knowledge for these new method’s positive aspects. It will be difficult to implement a major adjustment required within the timeframe for the 2030´s Agenda, but a shift towards sustainable development is necessary. The combined factors and requirements for regenerative agriculture are one solution to the climate change.

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Jones, Willie F. "Development of a cellular fiber spinning technology for regenerative medicine." Connect to this title online, 2006. http://etd.lib.clemson.edu/documents/1173995215/.

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26

Khan, Ameena Yasmeen. "Titanium dioxide coated activated carbon a regenerative technology for water recovery /." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000719.

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Bia, Jesse. "Sunshine technology and dream biology : perceptions of regenerative medicine in Japan." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10043354/.

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Regenerative medicine is enthusiastically celebrated in Japan. Cutting edge stem cell research and new translatable treatments are closely followed and championed: by individuals, the government, and media alike. This thesis will demonstrate how process occurs in Japan, and then explain why. Two critical reasons are posited for regenerative medicine’s extensive public endorsement. The first reason is regenerative medicine’s role in combating the effects of Japan’s demographic shift: an ongoing crisis in which the national population is both aging and shrinking at distressing rates. The demographic shift puts immense strains on healthcare infrastructure, the economy, and family dynamics, while also precipitating a rise in the prevalence of degenerative diseases. Regenerative medicine is perceived as a multivalent antidote for these demographic concerns. The second reason is regenerative medicine’s many points of continuity and symbiotic overlaps with the philosophies and methodological applications of kampo (traditional Japanese medicine). Within both regenerative medicine and kampo treatment contexts, healing is reflexive and internally oriented: medicine does not heal the body so much as small medical catalysts influence the body to heal itself – to regenerate. Participants viewed regenerative medicine and kampo as analogous, and in some cases, interchangeable. With data gathered over two consecutive years of multi-sited participant observation fieldwork in Japan, the story of regenerative medicine is deliberately told here through personal narratives, ethnography, and individual perceptions: the words and insights of participants. As a series of subjective biovalues, potentials, and imaginaries, regenerative medicine has become a malleable concept that extends far beyond just cellular therapies. In Japan, regenerative medicine manifests as hope for the immediate future, and as individuals project their optimism onto it, regenerative medicine can and does become whatever they want it to be.

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Harvey, Adam Benedict. "Study of an intermittent regenerative cycle for solar cooling." Thesis, University of Warwick, 1990. http://wrap.warwick.ac.uk/2701/.

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The study presented here is focused on the use of aqua-ammonia solution in a novel solar-powered refrigeration cycle intended to be suitable for use in the rural areas of developing countries. The cycle is referred to as a `intermittent regenerative' (IR) cycle, the term regenerative meaning in this context the use of heat recovery or recuperation. The first chapter describes the three better known cycles which may be considered for this application. The IR cycle is introduced as a hybrid development of these which offers the significant advantages of high efficiency while minimising complexity. Chapter 1 provides a methodology by which the novel aqua-ammonia system can be evaluated in comparison with existing systems. The second chapter surveys previous experimental work on solar driven aqua-ammonia cycles. Chapter 3 consists of a detailed design study of the new IR cycle based on computer modelling techniques. The study serves as an analysis of the cycle and allows the performance of the cycle, together with design features and component sizes, to be simulated in a variety of meteorological conditions. A number of original design proposals are evaluated through the modelling exercise. Chapter 4 summarises the results of a second separate modelling exercise which investigates the absorption phase of the cycle. Chapters 5 and 6 describe experimental work. The results of laboratory tests are compared with the predictions of the computer model and in the event serve to validate the theoretical characterisation made in chapter 3 of the performance of key components of the system. The energy efficiency of the system as measured by experiment is proved to correspond to theoretical prediction, so representing a significant advance on the performance of alternative systems. Chapter 7 addresses itself to the wider question of the social and economic validity of a device with the performance and cost of the IR device. A case study is undertaken which explores the potential role of the device in the fish trading economy of Zambia. The study provides data valuable in assessing the usefulness of the technology in helping to stimulate the under-capitalised rural economy of a developing country and in improving local food resource utilisation. Chapter 8 draws together the conclusions of the various chapters and provides an overall conclusion and comment on the value of the IR system. It is proved to have a high efficiency but not to have the robustness nor portability demanded for widespread application in remote locations. Nevertheless the likely life-time cost-effectiveness of the system is judged to be an improvement on existing alternatives and suggestions are made for further improvement.

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Hoover, Brett A. "Smart Cellector: A Proposal for the Development and Commercialization of a Cellular Imaging, Analysis and Processing Technology for Application in Regenerative Medicine." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1295655205.

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Sjöholm, Mikael. "Benefits of regenerative braking and eco driving for high-speed trains : Energy consumption and brake wear." Thesis, KTH, Spårfordon, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-31701.

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on mechanical brakes. The electric regenerative brakes can thus be used as normal service brake with minimum time loss.The first part of the study aims at developing a method to calculate wear on train brake pads. This is done by using a reformulated version of Archard’s wear equation with a temperature dependent wear coefficient and a temperature model to predict the brake pad temperature during braking. The temperature model is calibrated using trustworthy data from a brake system supplier and full-scale test results.By performing simulations in the program STEC (Simulation of Train Energy Consumption), energy consumption for different cases of high-speed train operations is procured and significant data for the wear calculations are found. Simulations include both “normal driving techniques” and “eco driving”. The driving styles were decided through interviews with train drivers and experts on energy optimized driving systems.The simulations show that more powerful drive systems reduce both energy consumption and travel time by permitting higher acceleration and energy regeneration while braking. Calculations show that since the electric motors could carry out more of the braking the wear of the mechanical brakes becomes lower.Eco driving techniques can help to further reduce the energy consumption and mechanical brake wear. This driving style can require some time margins though, since it takes slightly longer time to drive when using coasting and avoiding speed peaks. However, if used properly this should not have to affect the actual travel time, partly because some time margins are always included in the timetable.Even if new, more powerful, trains would have the ability to reduce energy consumption and brake wear it is also necessary to have an appropriate slip control system for the electric brakes, making it possible to use them also under slippery conditions. In this context it is important that the adhesion utilization is modest, about 12 – 15 % for speeds up to 100 km/h and lower at higher speeds.

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Singh, Pawanbir. "Enabling late-stage translation of regenerative medicine based products." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/6060.

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The primary aim of the thesis is to contribute to demonstrating how established and emerging science in the regenerative medicine (RM) domain can be translated into profitable commercial practice, and generate clinically- and cost-effective therapies. It achieves this by exploring and assessing underlying economics, including investment readiness and economic assessment, exploring regulatory and reimbursement frameworks, developing stem cell culture systems and assessing fit with clinical practice. The thesis is the first public domain wide-ranging analysis of business trends in the production, manufacturing and supply segments of the RM industry. It analyses the clinical potential of the domain as well as the translational and commercial challenges facing the industry. The industry is at a turning point as big pharmaceutical companies engage with RM in order to explore technologies as potential therapeutics and discovery tools. This unlocks the industry by confirming an exit path for RM based small- and medium-sized enterprises. Translation has come to be recognised as a core issue in the overall space and translation of regenerative therapies into the clinic is presently challenging, high-risk and expensive. This research addresses the question what are the mechanisms required to enable translation of emerging scientific knowledge into commercially viable clinical RM products? These mechanisms are particularly important as their creation involves and requires major investment decisions, which can determine the success or failure of RM developments and indeed of the companies concerned. The lack of well-established business models and the complexity of the domain suggested a conceptual approach drawing upon relevant literature from product and process development, applied business and revenue models, technological evolution and capital market ingenuity. The research was carried out in two phases. The first phase was concerned with identification of key challenges and mapping the overall industry emergence including emergence of related regulations to provide a context and framework for understanding the domain. Based on the emergence mapping a timeline of key parallel factors was identified, and their inherent connections explored to identify transforming events affecting and influencing multiple factors on the journey to clinical success within a business environment. This creates the reference model. The second phase was concerned with manufacturing a stem cell based therapeutic and applying health economic principles to determine available headroom for investment, cost of goods and return on investment, taking hearing disorders as a case exemplar, and exploring the behaviour of the net present value curve to identify key parameters affecting the economic positioning of this novel regime. A key output of the research is the investment readiness reference model. It integrates key RM business issues against reducing uncertainty and increasing value. The model argues that the complex nature of RM products means that the issues affecting industry emergence and development go well beyond the primarily scientific and technological concerns on which much current research focuses. The performance of RM firms ultimately hinges upon the successful clinical application of their developed products, the key step for creating and realising value, and their ability to deal with the fundamental business issues specific to the area. The framework deals with these business issues, which are investment & technology readiness, business models, organisational challenges, public policy and industry emergence. This thesis explores ideas that may bridge the chasm between the promise and reality of RM i.e. mechanisms to enable late stage translation of RM products. It links technological capability and business models for firms in the domain. Furthermore, it offers a unique perspective on the nature and characteristics of investment readiness and financial assessment, specifically identifying key parameters affecting economic positioning. The key contributions are therefore: New insights into the key challenges involved in realising the commercial potential of cell based therapeutics. Technology road mapping to link fundamental enabling technological capability for developing RM products with robust business plans integrating strategy, technology development and the regulatory and reimbursement framework. A generic investment readiness reference model generated from the enabling technology, value and supply chain structures to identify key indicators and characteristics of industry readiness. A novel experimental programme demonstrating expansion, maintenance and differentiation of human embryonic stem cells by manual and automated methods. New insights into economic positioning by mapping net present value, and economic analysis by estimating available headroom, cost of goods and return on investment for a putative hearing therapeutic.

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Betz, Oliver Bernd [Verfasser]. "Die Entwicklung einer beschleunigten, klinisch anwendbaren Gentransfer-Technologie zur in situ Regeneration von Knochengewebe / Oliver Bernd Betz." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1237221730/34.

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33

Wang, Ruichen. "Modelling, testing and analysis of a regenerative hydraulic shock absorber system." Thesis, University of Huddersfield, 2016. http://eprints.hud.ac.uk/id/eprint/30243/.

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Recoverable energy in vehicle suspension systems has attracted intensive attention in recent years for the improvement of vibration suppression performance and the reduction of energy dissipation. Various design concepts and structures of regenerative suspensions have been presented and investigated to recover the energy of linear motion and vibration between the vehicle body and chassis from road disturbances. These studies concentrate on the energy conversion from kinetic energy to electricity. Although a large number of concepts and models have been proposed and evaluated to regenerate power for reuse, the previous simulation works have used significantly simplified models without considering parameter uncertainties and system losses. In addition, experimental works are too simple to support for modelling optimisation. To advance the technology, a regenerative hydraulic shock absorber is investigated rigorously by examining the system at various developing stages including modelling all hydraulic, mechanical, and electromagnetic processes, simulating its behaviours, identifying its uncertain parameters/variables, fabricating a prototype of a commonly used shock absorber, testing its desirable performance and evaluating its on-road usability, which has given an accurate understanding of dynamic behaviours and power regeneration of a regenerative hydraulic shock absorber system. Based on the configuration of the prototype, a comprehensive mathematical model is developed for the regenerative hydraulic shock absorber system. The various losses and nonlinearity have been taken into account in modelling hydraulic, mechanical, and electromagnetic processes, which allow more detailed influences and agreeable predictions with the experimental work to be obtained. The introduction of the gas-charged hydraulic accumulator into the system has been explored in both modelling and testing to provide power smoothing in an attempt to give a more stable recoverable power. Model parameter identifications and refinements based on online data are systemically investigated. It has found that the pressures, rotation speeds and electrical outputs, which are readily available in the system, are sufficient to determine and refine uncertain model parameters such as the voltage constant coefficient, torque constant coefficient, generator internal resistance and rotational friction torque using a common least square method. The developed experimental rig and measurement systems for the study of regenerative hydraulic shock absorbers are designed and built. The variations in motor pressure and shaft speed under different excitations are evaluated, and also voltage output and recoverable power at different electrical loads are investigated. Additionally, the experimental work is not only used to validate the predicted results comprehensively, but also to offer a practical evaluation method for the system under various operating conditions. In particular, the system using piston-rod dimensions of 50-30mm achieves recoverable power of 260W with an efficiency of around 40% under sinusoidal excitation of 1Hz frequency and 25mm amplitude. Additionally, control strategies and their realisation on a general purpose PC computer are developed based on constant voltage, current and resistance schemes to carry out the investigation of the system performances, which allows it to be fully evaluated upon the compromise between the damping behaviour and power regeneration performance for different road conditions. Furthermore, the simulation of the entire system and parameter computations are all realised on the Matlab platform, which provides sufficient flexibility to take into account more influence factors for accurate and detailed analysis and thus can be an effective mathematical tool for further development research in this direction such as the optimisation of the structures, control strategies and system integrations.

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Hamid, Omar Abdulhakeem. "3D printing of a gradient-patterned tubular scaffold for central nervous system regenerative applications." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49801/.

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During the central nervous system (CNS) morphogenesis, chemical gradients of morphogens such as retinoic acid (RA) or sonic hedgehog play a central role in regulating CNS patterning and differentiation of neural subtypes. Recapitulation of these gradients in a 3D hydrogel matrix may provide a model for CNS tissue formation in vitro. 3D Printing technology offers an opportunity to reproduce the complex architecture of cell microenvironment. We have developed a 3D-printable alginate hydrogel bioink suitable for extrusion-based bioprinting. The bioink was characterised by shear thinning, high printing resolution and minimal adverse effects on cell viability. The bioink was successfully used to print mouse embryonic stem cells (mESCs)-laden constructs and supported their differentiation into neural-like cells. Extrusion-based bioprinting was used to 3D-print hybrid polycaprolactone (PCL)-alginate tubular scaffolds functionalised with a fluorescein isothiocyanate-conjugated bovine serum albumin (FITC-BSA) concentration gradient pattern. Quantification of the FITC-BSA concentrations in the scaffold showed a linear reduction in concentration as a function of scaffold’s distance (length). Tubular scaffolds printed with fibroblast-laden alginate supported cell viability and proliferation up to 6 days after printing. Next, the developed model was used to replicate the in vivo RA-induced directed differentiation of mESCs into spinal cord neurons. RA-concentration-dependent acquisition of neural identity was investigated using immunocytochemistry and flow cytometry analysis. RA promoted the formation of neurons with hindbrain and spinal cord identity and supressed the forebrain identity in a concentration-dependent manner. Among the investigated hydrogels, gelatine methacrylate (GelMA) supported neural differentiation and neurite outgrowth of the mESCs-derived embryoid bodies (EBs). Subsequently EBs-laden GelMA (5%) was successfully used as a bioink to print the hybrid PCL-hydrogel scaffolds. 3D Printing of EBs and RA-loaded GelMA in PCL scaffold induced differentiation of EBs into neurons with spinal cord positional identity. In conclusion, the model can be used for effective morphogens gradients delivery to replicate some of the complex processes of CNS development in vitro.

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Ahmed, Shehnaz. "Self-reporting scaffolds for in situ monitoring for regenerative medicine and tissue engineering applications." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49511/.

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This thesis describes the development and utilisation of a self-reporting scaffold to improve current monitoring methods of the cellular microenvironment. In vitro tissue models hold a lot of promise for regenerative medicine and tissue engineering. However, many models lack the ability to non-invasively monitor in situ cellular responses in a physiologically relevant environment. By development of electrospun self-reporting scaffolds and incorporation of flow culture conditions, this limitation can be overcome. Electrospun matrices have been shown to mimic the structural architecture of the native extracellular matrix, whilst flow conditions have been shown to regulate cellular processes, and enhance mass transport and nutrient exchange throughout polymeric scaffolds. Here we show the development of optically transparent self-reporting electrospun scaffolds that incorporate ratiometric pH-sensitive nanosensors and respond to biological and mechanical cues of the native extracellular matrix through exposure to shear stress. Optically transparent self-reporting scaffolds were fabricated by directly electrospinning pH responsive, ratiometric nanosensors within a gelatin biopolymer matrix. The sensors consist of a porous polyacrylamide matrix which encapsulates pH-sensitive fluorophores that exhibit an additive fluorescent response across the full physiological range between pH 3-8, and a pH-insensitive reference fluorophore. The self-reporting scaffold was able to support cell growth whilst being able to simultaneously monitor local pH changes in real time. A Quasi-Vivo® bioreactor system was also used to generate a flow of cell culture medium and expose cell-seeded scaffolds to a continual shear stress. This novel diagnostic scaffold and the use of flow conditions can help simulate enhance the understanding of in vitro conditions, and generate advanced simulations in vivo to facilitate tissue engineering and regenerative medicine applications.

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Kritzinger, Jacob Johannes. "The game of diminishing returns : Architecture as a regenerative agent of man and nature." Diss., University of Pretoria, 2018. http://hdl.handle.net/2263/63622.

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Mining related activities are more expansive than ever before, with population growth data showing an exponential increase. These societies form part of the world consumer market in which people are constantly buying products with a short life-expectancy, such as consumer electronic devices. More often than not, these mining activities occur in developing countries or rural areas. A repercussion of mines located long distances from active communities is the formation of new communities based solely on the monetary system of a mine. Various precedents show the societal damage caused by the inevitable closure of mines. This eventuality is not the only societal concern associated with mining communities; communities with few social binding factors. These spaces are often made up of individuals from geographically and culturally disparate spaces who are brought together solely in their united search for monetary stability. This often leaves these communities rife with xenophobic tendencies and unsustainably weak community identities. Can a system be created in which community identity can act as a social catalyst preventing the disintegration of communities abandoned by mines? The close-out plans, drawn up by mines, leaves a lot to be desired. Based on outdated environmental data and environmental laws, these closure plans offer very little environmental protection or land rehabilitation options, and nearly no protection of any kind for communities involved in mining activities. There lies irreversible societal and environmental damage in our near future, not only for South Africa, but worldwide, if we do not start offering up innovative ideas and possible solutions for these mining communities. This dissertation will investigate architecturally based solutions for community stability, and environmental stability, through the formation of a strong communal identity which will be based on environmental rehabilitation as the catalyst for stability. The proposed site exists as a no-man’s-land between the Refilwe Community and Cullinan diamond mines' largest slime dam. The constant expansion of the Refilwe community has pushed property development to the absolute limit, in terms of proximity to the slime dam. This community currently borders on this slime dam, hazardous to the humans and animals that live there.The history of Refilwe exemplifies pre-Apartheid and Apartheid laws of segregation; a political system which still affects the identity of the residents and the community as a whole today. Recent community-directed architectural failures leads this dissertation to reconsider how architecture can rehabilitate or assist a community. As a point of departure, this dissertation examines utilizing existing potential within a damaged space and analyses the significant community requirements at hand. The architectural response will primarily be based on information collected from various sources, including but not limited to: sites studies, environmental analyses, precedents and historical information. The programme was developed to utilize architecture as a response method for remediation of both man and nature. Myn gebasseerde aktiwiteite het 'n hoër produksie en verwagting as ooit tevore met die bevolking se eksponensiële toename. Hierdie gemeenskappe vorm deel van die wêreld se vebruikersmark. Die publiek koop aanhoudend produkte wat binne 'n paar jaar op die vullishoop beland, byvoorbeeld elektroniese objekte. Die meerderheid myne word gevind in onontwikkelde lande of in 'n plattelandse omgewing. Die nadeel van myne wat ver van stedelike gebiede is, is dat die nuwe gemeenskappe alleenlik gevorm word om die stigting van die myn. Dit is bewys dat die onvermydelike staking van produksie van myne veroorsaak sosiale verwoesting in sulke gemeenskappe. Dit is nie die enigste probleem nie. Hierdie gemeenskappe het geen sosiale groepseenheid nie en bestaan meestal van mense van verskillende agtergronde en plekke. Hulle is saamgegooi as gevolg van werksgeleenthede. Die gevolg daarvan is dat die gemeenskap se individuele identiteit swak is, en xenofobiese gevoelens ontstaan. Die vraag is, kan 'n sisteem ontwerp word om 'n gemeenskaplike identiteit te help vorm? Wat sal help om die gemeenskap bymekaar te hou en te ontwikkel na die myn toemaak? Die finale plan vir die toemaak van 'n myn is gewoonlik nie bevredigend genoeg nie. Gebaseer op verouderde omgewingsinformasie en omgewingswette word te min beskermings opsies aangebied vir die rehabilitasie van die gebied. Onomkeerbare sosiale en omgewingsvernietiging sal in die toekoms volg, nie net vir Suid-Afrika nie, maar wêreldwyd, indien ons nie begin kyk na nuwe kreatiewe idees, en moontlike oplossings vir hierdie myn gemeenskappe nie. Die verhandeling versoek en beoog 'n oplossing met argitektuur as basis en agtergrond, vir die gemeenskap en die omgewings stabiliteit, deur die vorming van 'n sterker gemeenskaps identiteit wat gebaseer word of omgewings rehabilitasie. Die voorgestelde terrein plan en ontwikkeling skep 'n buffer tussen die Refilwe gemeenskap en die Cullinan Diamant Myn se grootste slyk dam. Die aanhoudende populasie aanwas van die Refilwe gemeenskap het eindomsontwikkeling tot aan sy grense gestoot in terme van sy ligging tot die slyk dam. Huidiglik grens die gemeenskap aan die slyk dam wat 'n gesondheids risiko is vir mens en dier wat daar lewe. Die geskiedenis van Refilwe vertoonbeeld die tydperk van Apartheid en Apartheidswette van segregasie, 'n politiese sisteem wat tot vandag toe die identiteit van die inwoners en die gemeenskap negatief beinvloed. Onlangse gemeenskapsgedrewe argitektuur mislukkings, lei hierdie verhandeling na die heroorweging van hoe argitektuur 'n gemeenskap kan rehabiliteer. Ter afsluiting, ondersoek die verhandeling die moontlikheid om die huidige potensiaal te gebruik in 'n geaffekteerde ruimte en om die toepaslike gemeenskapbehoeftes te analiseer. Die argiteksgedrewe antwoord sal primêr gebaseer wees op data versamel van verskeie oorde, insluitende maar nie beperk tot: terreinstudies, omgewings analises, feite en historiese inligtig. Die projek was ontwikkel om argitektuur te gebruik as 'n moontlike antwoord vir die herstel van mens en die natuur en om 'n nuwe simbiose te skep. Mini Dissertation MArch(Prof)--University of Pretoria, 2018. Architecture MArch (Prof) Unrestricted

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Sodha, Sonal. "A microfabricated 3-D stem cell delivery scaffold for retinal regenerative therapy." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/54593.

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Thesis (M. Eng.)--Harvard-MIT Division of Health Sciences and Technology, 2009. Cataloged from PDF version of thesis. Includes bibliographical references (p. 59-61). Diseases affecting the retina, such as Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP), result in the degeneration of the photoreceptor cells and can ultimately lead to blindness in patients. There is currently no cure for AMD or RP, and only a few methods exist for slowing the progression of these diseases. Although there has been much recent headway in cell replacement therapy to restore vision loss, a number of challenges still remain. More specifically, there is a need for the development of a device that can deliver a large number of cells to the posterior segment of the eye, while promoting cell survival, differentiation and integration into the retina following transplantation. This research focuses on designing a device to meet these demands and improve the vision of those afflicted with blinding diseases. The specific hypothesis behind the proposed research is that a MEMS-based strategy to engineer a device can provide precisely defined spatial and chemical cues to influence retinal progenitor cells (RPCs) attachment, promote differentiation, and provide physical guidance in a more normal anatomical organization for their integration as neurosensory retina after transplantation to the subretinal space. Therefore, the specific aims of this research are to design, fabricate, and evaluate in vitro a novel ultrathin 3-D device made of polycaprolactone (PCL) for retinal cell replacement synthesized by the stacking, aligning, and bonding of three uniquely designed layers. (cont.)Photolithography, standard replica molding, and soft lithography techniques are used to fabricate the device elements. The 3-D device is designed with a defined cage structure to encapsulate a large number of cells. Another layer of the design allows for unidirectional cell migration out of one end into the subretinal space with the aid of contact guidance ridges. The third design layer allows for nutrient infiltration from the retinal pigment epithelium into the cell cages. The ultimate goal is to provide an environment compatible with the normal retinal tissue and conducive to the formation of functional synapses under the appropriate conditions, thereby restoring proper vision. With demonstration of efficacy and cell retention in vitro, the scaffold has the potential to reverse retinal degeneration due to disease or trauma and improve retinal function and integrity in vivo. by Sonal Sodha. M.Eng.

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Canseco, José Antoni. "Tissue engineering the anterior cruciate ligament : a regenerative medicine approach in orthopaedic surgery." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83965.

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Thesis (Ph. D. in Biomedical Engineering)--Harvard-MIT Program in Health Sciences and Technology, 2013. Vita. Cataloged from PDF version of thesis. Includes bibliographical references (pages 85-97). Anterior cruciate ligament (ACL) injuries affect over 200,000 Americans yearly, and many occur in young athletes. Current treatment options include tendon autografts and cadaveric allografts. However, these approaches often lead to secondary medical problems, such as donor-site morbidity and immune rejection. Furthermore, in younger patients these grafts fail to grow, leading to additional complications and underlining the need for the development of new approaches that improve the healing and repair of ligaments and tendons. This thesis aims to develop a technique to engineer ACL from autologous mesenchymal stem cells (MSC) and primary ACL fibroblasts using the basic principles of Tissue Engineering. The first part of the thesis characterizes MSCs isolated from tibial bone marrow as an alternative to hip-derived marrow aspirates. The proximity of the tibia to the surgical site of ACL reconstructions makes it a viable source of marrow derived-MSCs for ligament repair, with less stress for the patient and increased flexibility in the operating room. Characterization was performed by fluorescenceactivated cell sorting for MSC-surface markers, and assays to differentiate MSCs towards adipogenic, osteogenic and chondrogenic lineages. The second part of the thesis describes the effects of in vitro co-cultures of ACL fibroblast and MSC on the expression of ligament-associated markers. The goal was to optimize the cell-cell ratio in order to maximize the positive effects of co-cultures on ligament regeneration. Co-cultures of ACL fibroblasts and MSCs were studied for 14 and 28 days in vitro, and the effects assessed with quantitative mRNA expression and immunofluorescence of ligament markers Collagen type I, Collagen type III and Tenascin-C. Finally, based on the enhancing effect observed in co-cultures, the thesis explores a method to regenerate ACL using a three-dimensional polyglyconate scaffold seeded with cell-hydrogel suspensions containing ACL fibroblasts and MSCs. Constructs were analyzed biochemically and by immunofluorescence after 4 weeks in culture with and without mechanical stimulation. Together, our results establish an experimental framework from which a new technique for ACL repair can be developed. The ultimate goal is to foster the design of a one-stage surgical procedure for improved primary ACL augmentation repair that can soon be translated into clinical practice. by José Antonio Canseco. Ph.D.in Biomedical Engineering

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Chou, Hsueh-Chih, and 周學志. "Regeneration Technology Study of Valve Regulated Lead-Acid Batteries." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/85ede4.

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碩士 國立臺北科技大學 新能源電控產業碩士專班 101 Lead ingots are used to produce valve-regulated sealed lead-acid batteries. As the price of lead has increased worldwide, various domestic public and private companies have been forced to increase their budgets to replace numerous batteries each year. In the disrupted global economic situation, this generates a budgetary challenge. In this study, regeneration technology was applied to extend battery life, reduce costs and pollution, and conserve energy. Instead of employing general automotive lead-acid batteries, the researcher regenerated valve-regulated lead-acid batteries, which account for the highest percentage of the total product value in the lead-acid battery market, facilitating economically beneficiary regeneration, and exhibiting market potential. The same regeneration theory is applied to various regeneration technologies. To regenerate lead-acid batteries, the lead sulfate crystals inside are dissolved and reduced to a negative lead electrode plate of lead and a positive lead dioxide battery plate of lead dioxide. After evaluating several regeneration technologies, the researcher employed the shark-pulse technique technology for the regeneration experiment and assessed its theoretical feasibility and logic. Regeneration experiments were conducted using multiple batteries, examining whether the regenerated batteries met actual usage requirements or demonstrated only temporary effectiveness. The experimental results showed that the discharge performance of regenerated batteries was many folds higher compared with pre-regeneration batteries. Therefore, battery regeneration technology substantially contributes to cost reduction, energy conservation, and environmental protection.

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Nave, Joana Vicente. "Drug Delivery Systems for Bone Regeneration." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/88773.

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Nave, Joana Vicente. "Drug Delivery Systems for Bone Regeneration." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/88773.

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Chen, Tai-an, and 陳泰安. "Study of Reef-building Technology: Regeneration and Growth of Acropora Fragments." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/47090617134602635517.

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碩士 國立中山大學 海洋生物研究所 86 We studied how to effectively increment new reefs by using fast growing branching Acropora intermedia and A. formosa (tentatively identified) fragments from 1996 to 1998 at Nanwan. In the first part, we want to know under what conditions coral fragments survive and grow fast. We found that longer coral fragments have higher extension rates (cm/30 days) and lower mortality rates due to alga coverage than shorter ones. By cutting the original branches into more fragments would result in higher overall extensiIn the second part, we transplanted coral fragments to two different depths at Tiaoshih. We found the extension rates were higher and new branch initiation was earlier at 5 m than at 10 m depth. And we also tried two large area experiments (15 m2) at Nanwan. One was destroyed by typhoon during the first summer, but the other one at Hobihu was still intact after 13 months. The survival rate was 98.7% in the first six months. And during this period, average extension length was 6.7-8.7 cm per fragment and 11%-1 -aStudy of Reef-building Technology: Regeneration and Growth of Acropora Fragments.

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Vaz, Raquel Sofia Remoaldo. "Direct Stimulation for Ligament Regeneration." Master's thesis, 2019. https://hdl.handle.net/10216/121153.

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Faria, Matilde Lima de. "Magnetic Scaffolds for Bone Regeneration." Dissertação, 2020. https://hdl.handle.net/10216/129256.

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Faria, Matilde Lima de. "Magnetic Scaffolds for Bone Regeneration." Master's thesis, 2020. https://hdl.handle.net/10216/129256.

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Santos, Daniel Alberto Oliveira. "Multifunctional Electrospun Fibre Membranes Associated to Bone Grafts for Bone Regeneration." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/88083.

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Morgado, Marlene Marques. "Modulating the extracellular environment during axonal regeneration following spinal cord injury." Dissertação, 2014. https://repositorio-aberto.up.pt/handle/10216/89256.

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FAN, CHIU-TIEH, and 范秋鐵. "The Research on the Importance of Mold Repair Welding Regeneration Technology to Forging Plant." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/nx3ymv.

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碩士 國立雲林科技大學 高階管理碩士學位學程 107 With the rise of environmental awareness in recent years, energy conservation and carbon reduction has become an active goal of industry and manufacturing industry in various countries. In the early days, steel smelting created many environmental problems, which were replaced by the technology of mold welding and regeneration. This technology ues high alloy heat and abrasion resistant high speed steel to weld and repair the base material of the mould, which not only reduces the damage to the environment but also reduces the cost of making new mould.

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Rodrigues, Sílvia Maria do Couto. "Exploring the cardiac response to injury: new clues to enhance repair/regeneration." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/89353.

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Santos, Daniel Alberto Oliveira. "Multifunctional Electrospun Fibre Membranes Associated to Bone Grafts for Bone Regeneration." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/88083.

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