Добірка наукової літератури з теми "Recombination activating genes"
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Статті в журналах з теми "Recombination activating genes"
Haines, Brian B., Chun Jeih Ryu, and Jianzhu Chen. "Recombination Activating Genes (RAG) in Lymphoma Development." Cell Cycle 5, no. 9 (April 19, 2006): 913–16. http://dx.doi.org/10.4161/cc.5.9.2732.
Повний текст джерелаPanchin, Yuri, and Leonid L. Moroz. "Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes." Biochemical and Biophysical Research Communications 369, no. 3 (May 2008): 818–23. http://dx.doi.org/10.1016/j.bbrc.2008.02.097.
Повний текст джерелаLi, Tong-Tong, Shuhua Han, Mike Cubbage, and Biao Zheng. "Continued expression of recombination-activating genes and TCR gene recombination in human peripheral T cells." European Journal of Immunology 32, no. 10 (October 2002): 2792–99. http://dx.doi.org/10.1002/1521-4141(2002010)32:10<2792::aid-immu2792>3.0.co;2-i.
Повний текст джерелаOhmori, Hitoshi, та Masaki Hikida. "Expression and Function of Recombination Activating Genes in Mature В Cells". Critical Reviews™ in Immunology 18, № 3 (1998): 221–35. http://dx.doi.org/10.1615/critrevimmunol.v18.i3.30.
Повний текст джерелаGennery, Andrew R., Elizabeth Hodges, Anthony P. Williams, Susan Harris, Anna Villa, Brian Angus, Andrew J. Cant, and John L. Smith. "Omenn's syndrome occurring in patients without mutations in recombination activating genes." Clinical Immunology 116, no. 3 (September 2005): 246–56. http://dx.doi.org/10.1016/j.clim.2005.04.014.
Повний текст джерелаLamb, Teresa M., and Aaron P. Mitchell. "Coupling of Saccharomyces cerevisiae Early Meiotic Gene Expression to DNA Replication Depends Upon RPD3 and SIN3." Genetics 157, no. 2 (February 1, 2001): 545–56. http://dx.doi.org/10.1093/genetics/157.2.545.
Повний текст джерелаYannoutsos, Nikos, Patrick Wilson, Wong Yu, Hua Tang Chen, Andre Nussenzweig, Howard Petrie, and Michel C. Nussenzweig. "The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo." Journal of Experimental Medicine 194, no. 4 (August 20, 2001): 471–80. http://dx.doi.org/10.1084/jem.194.4.471.
Повний текст джерелаJessen, Jason R., Tammy N. Jessen, Steven S. Vogel, and Shuo Lin. "Concurrent expression of recombination activating genes 1 and 2 in zebrafish olfactory sensory neurons." genesis 29, no. 4 (2001): 156–62. http://dx.doi.org/10.1002/gene.1019.
Повний текст джерелаTsai, Albert G., and Michael R. Lieber. "RAGs found “not guilty”: cleared by DNA evidence." Blood 111, no. 4 (February 15, 2008): 1750. http://dx.doi.org/10.1182/blood-2007-09-113381.
Повний текст джерелаOltz, E. M., F. W. Alt, W. C. Lin, J. Chen, G. Taccioli, S. Desiderio, and G. Rathbun. "A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination." Molecular and Cellular Biology 13, no. 10 (October 1993): 6223–30. http://dx.doi.org/10.1128/mcb.13.10.6223-6230.1993.
Повний текст джерелаДисертації з теми "Recombination activating genes"
Verkoczy, Laurent Karl. "Regulation studies of the human recombination activating genes, RAG-1 and RAG-2." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1995. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ51544.pdf.
Повний текст джерелаHsu, Lih-Yun. "Regulation of recombination activating genes and B cell development by cis-activating elements and trans-acting protein pax-5." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080681.
Повний текст джерелаZarrin, Ali Akbar. "Characterization of the human recombination activating gene 1 (RAG1) and RAG2 promoter regions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0024/NQ49915.pdf.
Повний текст джерелаCabral, Barreto Vasco. "Allelic exclusion of the murine immunoglobulin heavy chain." Paris 6, 2001. http://www.theses.fr/2001PA066537.
Повний текст джерелаBas, Anna. "Extrathymic T cell receptor gene rearrangement in human alimentary tract." Doctoral thesis, Umeå University, Clinical Microbiology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169.
Повний текст джерелаT lymphocytes regulate the initiation, duration, and magnitude of adaptive immune responses and function as effector cells in cell mediated immunity. To become immunologically competent they must generate functional antigen receptors. This process takes place in the thymus and requires somatic recombination of T cell receptor (TCR) genes. It is mediated by the endonucleases recombination activating gene-1 (RAG1) and RAG2. Although the thymus regresses at puberty, T cells are present throughout life implying that other tissues must provide the proper milieu for T cell development. This thesis describes extrathymic T cell maturation in man. RAG1, RAG2, and the preTα-chain (pTα), which is exclusively utilized in developing T cells, were used as markers for TCR gene rearrangement. Two new exons (1A and 1B) encoding sequences in the 5’ untranslated region (5’UTR) of mRNA were discovered in the human RAG1 gene. The previously described 5’UTR exon (renamed 1C) was located between the new exons and exon 2, the latter containing the entire coding sequence. We found that small intestinal lymphocytes of the T cell lineage expressed the new exons in three different splice forms. RAG1 mRNA containing the 1C exon was not expressed in small intestinal lymphocytes. In contrast, splice forms containing the 1A exon were not expressed in thymocytes. RAG1 and pTα mRNA expressing lymphocytes were seen both within the epithelium and in lamina propria. Thymocyte-like CD2+CD7+CD3-, CD4+CD8+, CD1a+, and IL7-R+ lymphocytes were identified in the small intestinal mucosa. CD2+CD7+CD3- cells had the highest expression levels of mRNA for RAG1 and pTα, suggesting that the small intestinal mucosa is indeed a site for T cell maturation. Small intestinal T lymphocytes were also shown to kill via the Fas/FasL pathway in a TCR/CD3 independent manner and via the perforin/granzyme pathway in a TCR/CD3 dependent manner. The Fas/FasL-mediated cytotoxicity may reflect an ongoing selection process of extrathymically maturated T cells.
The nasopharyngeal tonsil is the major inductive site for immune reactions against inhaled antigens. Previous demonstration of RAG1 expression in tonsillar B cells was interpreted as antigen driven receptor revision. The present study confirms the expression of RAG1 in B cells. We also found that RAG1, RAG2, and pTa mRNAs were expressed in lymphocytes of the T cell lineage. A small population of cells with the immature phenotype CD2+CD7+CD3- was demonstrated. This population had the highest expression levels of mRNA for RAG1, RAG2, pTα and terminal deoxynucleotidyl transferase. All four splice-forms of RAG1 mRNA were expressed. RAG1 and pTα mRNA expressing cells were mainly located in the proximity of the surface epithelium and in the outer rim of the follicles. These results suggest that the nasopharyngeal tonsil is a site where extrathymic T cell development and antigen driven TCR revision are occurring in parallel.
Celiac disease (CD) is a small intestinal enteropathy characterized by permanent intolerance to gluten. Gluten reactive intestinal T cells are central in the pathogenesis and CD can be regarded as a failure to maintain tolerance to this food antigen. Expression of the RAG1 1A/2 splice form was significantly decreased in small intestinal T cell subsets of CD patients suggesting that impaired TCR gene rearrangement could contribute to failure of maintain tolerance in CD.
Together, these findings show that both small intestinal and nasopharyngeal tonsillar lymphocytes of T cell lineage have the molecular machinery for antigen receptor rearrangement and that thymocyte-like lymphocytes are present in both tissues. Thus these organs are likely sites of T lymphocyte ontogeny as well as for secondary T cell receptor rearrangement in man.
Kumari, Rupa. "Mechanism of RAG Regulation During Its Physiological and Pathological Functions in Lymphoid Cells." Thesis, 2015. http://etd.iisc.ernet.in/2005/3944.
Повний текст джерелаWang, Ya-Jean, and 王雅貞. "Cloning recombination activating gene 1 and 2 ( rag1 and rag2 ) and analyzing of the genes expression in adaptive immunity ontogenesis of Orange-Spotted Grouper (Epinephelus coioides)." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/38350825233940536103.
Повний текст джерела國立成功大學
生物學系碩博士班
97
Orange-spotted grouper (Epinephelus coioides) is a fish species with a high economic importance in the aquaculture industry in Taiwan. The high mortalities observed throughout early development such as viral nervous necrosis (VNN) causes the highest mortalities up to 100% always occur among 1-month-old larvae with total body lengths of 2.0 cm. Teleost is the oldest species has the adaptive immune system. However, there is a risk of inducing immunological tolerance if fish that are immunised at a very early age before they are immunocompetent. Thus, it is important to establish the earliest time that grouper can be vaccinated or give immunopotentiating agent. Recombination activating genes, rag1 and rag2, encode components of the recombinase involved in V(D)J recombination. During B lymphocyte development, the variable region of Ig gene is assembled by the recombination of multiple V, D, J segments, which can generate a vast array of immunoglobulin M (IgM) to against numerous antigen. IgM produced by B lymphocytes is also an important gene that can be used in the study of the ontogenesis of the immune system, as it is the first formed antibody of the primary humoral component of the acquired immune system in fish species. These genes are expressed together in this study in order to understand the expression profile of them. The genes, rag1 and rag2, of E. coioides were cloned and sequenced the open reading frames. The full-length cDNA of rag1 and rag2 were 3653 and 1875 base pairs (bp) long respectively. The lengths of rag1 and rag2 open reading frame were 3216 and 1602 bp encoding 1071 and 533 amino acids with the molecular weight of putative protein were about 117 and 58 kDa. Subsequently, the rag1, rag2 and IgM mRNA expression level in ontogeny of fish and different organs was evaluated by reverse transcriptase PCR (RT-PCR). The result showed the expression level of rag1, rag2 and IgM mRNA raised after 13, 13 and 22 dpf of fries respectively. This data was suggested that orange-spotted grouper at this stage might possess mature immunity and is able to produce immunoglobulin. The expression of rag1 was observed in thymus, head kidney and trunk kidney. The expression of rag2 was observed in thymus and head kidney. The expression of IgM was observed in thymus, head kidney, trunk kidney, spleen, intestines and pancreas. This data forms the basis for a proposal that the thymus and head kidney of teleost species play an essential developmental role in lymphopoiesis and thus can be regarded as a primary lymphoid organ.
Naik, Abani Kanta. "Mechanism Of RAG Action As A Structure-Specific Nuclease : Implications In Genomic Instability In Lymphoid Cells." Thesis, 2011. http://etd.iisc.ernet.in/handle/2005/2127.
Повний текст джерелаDeepthi, R. "Molecular Insights into Lymphoid Malignancy : Role of Transcription Factor BCL11B in T-cell Leukemia Genesis and Biochemical Characterization of DNA Binding Domain of RAG1." Thesis, 2017. http://etd.iisc.ernet.in/2005/3773.
Повний текст джерелаOrthwein, Alexandre. "Importance of the HSP90 molecular chaperoning pathway for antibody diversification by determining AID stability." Thèse, 2012. http://hdl.handle.net/1866/7105.
Повний текст джерелаActivation induced deaminase (AID) plays a central role in adaptive immunity. AID deaminates deoxycytidine to deoxyuridine in defined regions of the immunoglobulin (Ig) genes and initiates somatic hypermutation (SHM), gene conversion (iGC) and class switch recombination (CSR). While being essential for an effective immune response by underpinning antibody affinity maturation and isotype switching, the mutagenic activity of AID can also be oncogenic and causes genomic instability leading to the development of cancer, or exacerbate autoimmune diseases. Therefore, AID regulation, including the control of its protein level, is central to balancing effective immunity with cancer/autoimmunity. Notably, AID shuttles between the cytoplasm and the nucleus but is predominantly cytoplasmic at steady-state, with cytoplasmic AID being much more stable than nuclear AID. These regulatory steps contribute to limit the exposure of the genome to AID but their mechanisms are unknown. This thesis aimed at identifying AID partners and intrinsic determinants regulating its stability and modulating its biological functions. Firstly, we identified AID as a novel HSP90 client protein. We demonstrated that HSP90 interacts with AID in the cytoplasm and prevents its polyubiquitination and subsequent proteasomal degradation. Consequently, HSP90 inhibition results in a significant reduction of endogenous AID levels and correlates with a proportional reduction in both AID-mediated antibody diversification and off-target mutations. Secondly, we showed that the first step in the HSP90 molecular chaperoning pathway and stabilization is the interaction of AID with the HSP40 and HSP70 system. In fact, a specific HSP40 protein, DnaJa1, is the limiting step in cytoplasmic AID stabilization. DnaJa1 farnesylation is required for DnaJa1-AID interaction and modulation of DnaJa1 levels or its farnesylation impacts endogenous AID levels and antibody diversification. In vivo, DnaJa1- deficient mice display compromized response to immunization, resulting from reduced AID protein levels and isotype switching. Thirdly, we found that AID is intrinsically less stable than its APOBEC paralogs. We identified the AID N-terminal aspartic acid residue at position two and an internal PEST-like motif as destabilizing modulators of AID protein turnover. Disruption of these motifs increases AID protein stability and antibody diversification.We conclude that AID’s intrinsic instability directly contributes to regulating antibody diversification. This intrinsic instability is at least partially compensated for in the cytoplasm by the protective action of the DnaJa1-HSP90 molecular chaperoning pathway. Pharmacologically targeting AID in an indirect way, by using HSP90 or farnesyltransferase inhibitors, could be relevant for treating some AID-associated lymphomas/leukemias and/or autoimmune diseases.
Книги з теми "Recombination activating genes"
Verkoczy, Laurent Karl. Regulation studies of the human recombination activating genes (RAG-1 and RAG-2). Ottawa: National Library of Canada, 1995.
Знайти повний текст джерелаJoyner, Alexandra, ed. Gene Targeting. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637928.001.0001.
Повний текст джерелаVoll, Reinhard E., and Barbara M. Bröker. Innate vs acquired immunity. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048.
Повний текст джерелаЧастини книг з теми "Recombination activating genes"
Hansen, J. D., and J. F. McBlane. "Recombination-Activating Genes, Transposition, and the Lymphoid-Specific Combinatorial Immune System: A Common Evolutionary Connection." In Current Topics in Microbiology and Immunology, 111–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-59674-2_6.
Повний текст джерелаBaltimore, D., M. Oettinger, and D. Schatz. "The Recombination Activating Gene and Lymphoid Differentiation." In Progress in Immunology, 385–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83755-5_50.
Повний текст джерелаTeubl, Fabian, Katrin Schwank, Uli Ohmayer, Joachim Griesenbeck, Herbert Tschochner, and Philipp Milkereit. "Tethered MNase Structure Probing as Versatile Technique for Analyzing RNPs Using Tagging Cassettes for Homologous Recombination in Saccharomyces cerevisiae." In Ribosome Biogenesis, 127–45. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_8.
Повний текст джерелаGrawunder, Ulf, Thomas H. Winkler, and Fritz Melchers. "Regulation of Recombination Activating Gene Expression During Lymphocyte Development." In Current Topics in Microbiology and Immunology, 31–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-50140-1_3.
Повний текст джерелаHamaguchi, Yasushi, Norisada Mastunami, Yoshiki Yamamoto, Kogo Kuze, Kenji Kangawa, Hisayuki Matsuo, Masashi Kawaichi, and Tasuku Honjo. "Cloning and Characterization of a Protein Binding to the Jκ Recombination Signal Sequence of Immunoglobulin Genes." In Mechanisms of Lymphocyte Activation and Immune Regulation III, 177–86. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5943-2_20.
Повний текст джерела"RAG1, RAG2 (recombination activating gene)." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1630–31. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_14074.
Повний текст джерелаChun, Jerold J. M., and David G. Schatz. "Recombination activating gene-1 (RAG-1) transcription in the mammalian CNS." In Neuronal Cell Death and Repair, 283–95. Elsevier, 1993. http://dx.doi.org/10.1016/b978-0-444-81470-8.50027-2.
Повний текст джерелаVoll, Reinhard E., and Barbara M. Bröker. "Innate vs acquired immunity." In Oxford Textbook of Rheumatology, 356–64. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048_update_001.
Повний текст джерелаТези доповідей конференцій з теми "Recombination activating genes"
Hu, Jiazhi, Yu Zhang, Lijuan Zhao, Richard Frock, Zhou Du, Robin M. Meyers, Feilong Meng, David G. Schatz, and Frederick W. Alt. "Abstract A180: Topologically associated domains genome-wide restrict the off-target activity of recombination activating gene 1/2 endonuclease." In Abstracts: CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr15-a180.
Повний текст джерелаЗвіти організацій з теми "Recombination activating genes"
Hodges, Thomas K., and David Gidoni. Regulated Expression of Yeast FLP Recombinase in Plant Cells. United States Department of Agriculture, September 2000. http://dx.doi.org/10.32747/2000.7574341.bard.
Повний текст джерелаNorelli, John L., Moshe Flaishman, Herb Aldwinckle, and David Gidoni. Regulated expression of site-specific DNA recombination for precision genetic engineering of apple. United States Department of Agriculture, March 2005. http://dx.doi.org/10.32747/2005.7587214.bard.
Повний текст джерела