Дисертації з теми "Real tori"

In this thesis we study real structures on compact toric varieties. After proving that their number (up to conjugation) is finite, we limit ourselves to toric real structures i. E. , real structures that normalize the action of the torus and define equivalencies between them. Then we calculate an upper bound of the number of non-equivalent such structures. We list explicitely the groups generated by toric real structures in dimension 2 and 3 and determine some minimal models for surfaces. We are also interested in the real toric variety. We prove that it is pathwise-connected when it is non-empty and give the complete list of its topological types in case of surfaces and fano-threefolds. We end this work by the application to the toric threefolds equipped with their canonical real structures of a Kollar's conjecture:Is a real hyperbolic connected treefold the real part of some complex projective rational variety ?

The essay makes a case for the use of the Nobel Prize-winning (1993) author Toni Morrison's novel The Bluest Eye (1970) in the English language classroom. The essay argues that the novel is an excellent reading choice and to what is appropriate according to the learning goals stated in Gy11's course syllabus English 6. Since the course English 6 syllabus is new some aspects different from previous course syllabus English B are mentioned by way of comparison.  In order to develop the arguments for using the novel, different perspectives of reading and the learning process are discussed and how they match the curriculum Gy 11. Some points about how Morrison has managed to voice the former unspoken experiences of African American society are made to make it clear why reading The Bluest Eye is such a superb text in relation to the learning goals that are outlined in Gy11.The essay focuses mainly on mother - daughter relationships because most pupils will easily relate to this theme since they have experiences of this relation themselves, and therefore they will find it easy to find issues to discuss after reading the novel.

O objetivo principal deste trabalho é o estudo da regularidade anallítica global de certos operadores diferenciais definidos no toro. Uma ferramenta fundamental utilizada neste estudo são as séries parciais de Fourier, que nos permitem caracterizar tanto as distribuições periódicas quanto as funções anallíticas reais periódicas através do comportamento assintótico de seus coeficientes parciais de Fourier. Neste sentido, apresentamos também um estudo detalhado das relações destes objetos com seus coeficientes parciais de Fourier
The main goal of this work is to study global analytic regularity properties of certain differential operators acting in the torus. A main tool that will be used to achieve our goals are the partial Fourier series, which allow us to characterize objects such as periodic distributions or periodic real analytic functions in terms of the growth of their partial Fourier coefficients

Le superfici topologiche possono essere modellate a proprio piacimento attraverso degli omeomorfismi, poichè due superfici omeomorfe sono topologicamente equivalenti. Tuttavia la proprietà del genere rimane invariata per omeomorfismi, quindi è possibile classificare una superficie in base al suo genere. Una curva algebrica nel proiettivo complesso è topologicamente equivalente ad una superficie compatta e orientabile.

This research develops eight recommendations for amendments to key Ontario legislation affecting Brownfield redevelopment that, if implemented, will reduce the liability and risk associated with the development of contaminated land and benefit stakeholders, such as, municipalities and developers. Utilizing the methodology of law and economics, this research examines the legal landscape in Ontario and expands the dialogue regarding the risks of developing contaminated land. Through this examination, this research uncovers the origins of the risks of Brownfield redevelopment and extrapolates recommendations for amendments to legislation and policy that balance the liability of Brownfield redevelopment with the protection of the environment. Recent developments in environmental law appear to increase environmental protection, but actually limit Brownfield redevelopment in Ontario by increasing liability and costs. The polluter pays principle that has been entrenched in Canadian law has governed the law in respect of contaminated lands for decades. However, as society evolves, the common law is forced to re-evaluate environmental protection in the face of contaminated lands. This evolution of the law is an attempt to intervene to correct a market failure that exists with respect to contaminated lands. The increased liability associated with Brownfield redevelopment translates into heightened costs to redevelop the land, which also severely threatens environmental justice in Ontario. The recommendations in this research will benefit stakeholders, the public, and the environment. With respect to stakeholders, it will be of assistance to municipalities, cities, developers, corporations, secured lenders, mortgage insurers and the government. The risks associated with Brownfield redevelopment can be offset by the recommended corrections to legislation regarding liability and stronger policies that create accessible programs and incentives to promote just, innovative, and sustainable redevelopment.

Definované markery tvoří základ určování polohy kamery pro velké množství aplikací s rozšířenou realitou, v případě že jsou přísné požadavky na rychlost a robustnost. Tato práce popisuje účinnou metodu pro určení pózy kamery pomocí Uniformního pole markerů a několik realistických aplikací na bázi popsané metody. Metoda je velice výpočetně levná a poskytuje spolehlivou detekci pro několik výpočetních platforem, včetně běžných chytrých telefonů. Markery jako část zobrazené informace na monitorech jsou použité v této práci pro určení relativní orientaci mezi poskytovatelem obsahu a užívatelským zařízením, sloužícím pro výběr prvků užívatelského rozhraní při  interakci a migraci úkolů. Ve filmařském průmyslu poskytuje popsaná metoda pro zjištění polohy kamery jako součást klíčovaní pozadí filmářům živý náhled virtuální scény. Výsledky ukazují, že popsaná metoda pro detekci pole markerů má srovnatelnou úspěšnost a přesnost v porovnání s ostatními metodami na bázi markerů a je několikrát rýchlejší. Aplikace zahrnuté v této práci podle výsledků testů jsou životaschopné - rychlejší a levnější - alternativy k existujícím řešením.

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Introdução: O transplante renal é considerado uma opção de terapia renal substitutiva segura para pacientes acima de 60 anos, entretanto, não há consenso sobre o melhor esquema imunossupressor para o paciente transplantado renal idoso. Objetivo: Avaliar a eficácia e segurança da combinação de tacrolimus e sirolimus em doses reduzidas comparada com a associação tacrolimus e micofenolato. Métodos: Estudo prospectivo randomizado de centro único comparando a combinação de tacrolimus e sirolimus em dose reduzida (grupo sirolimus) contra tacrolimus e micofenolato (grupo micofenolato). Foram incluídos todos os pacientes transplantados renais maiores de 60 anos. Foram avaliadas a sobrevida do paciente e enxerto, taxas de rejeição, função renal e incidência de infecção por citomegalovírus (CMV) em 12 meses de seguimento. Resultados: Foram randomizados 46 pacientes e analisados 44 casos (dois casos excluídos por não terem sido transplantados). As características basais dos grupos foram semelhantes sendo todos os casos transplantados com doador falecido e a maioria induzida com basiliximabe. O grupo micofenolato (n=23) e o grupo sirolimus (n=21) apresentaram sobrevida do paciente e enxerto censurado óbito respectivamente de 95,7% e 100% para o micofenolato e 79,6% e 90,5% para o sirolimus sem diferenças estatísticas. A incidência de rejeição e função renal ao longo de 12 meses foi semelhante entre os grupos. A infecção de ferida operatória, retardo de função do enxerto e proteinúria foram semelhantes entre os grupos. O colesterol total e HDL colesterol foram maiores no grupo sirolimus. A infecção por CMV ocorreu em 60,9% no grupo micofenolato e 16,7% no grupo sirolimus apresentando um risco relativo 3,54 [1,2 – 10,3] vezes maior no grupo micofenolato, p=0,004. Conclusão: No grupo de transplantados renais idosos a combinação de tacrolimus e sirolimus em doses reduzidas foi segura mantendo taxas semelhantes de função renal em 12 meses, rejeição e sobrevida do enxerto e paciente. As principais complicações associadas ao sirolimus foram semelhantes com exceção de maiores taxas de colesterol total. A incidência de CMV foi significativamente menor no grupo sirolimus.
Introduction: Renal transplantation is considered safe for patients over 60 years, however, there is no consensus on the best immunosuppressive regimen in elderly. Objective: To evaluate the combination of tacrolimus and sirolimus in reduced dose in renal function comparing the combination tacrolimus and mycophenolate. Methods: A single-center prospective randomized study comparing the combination of tacrolimus and sirolimus in reduced dose (sirolimus group) against tacrolimus and mycophenolate (mycophenolate group). We included all kidney transplant patients over 60 years of age. We evaluated patient survival, biopsy prove acute rejection, renal function and incidence of cytomegalovirus (CMV) at 12 months of follow-up. Results: 46 patients were randomized and we analyzed 44 cases (two cases excluded because they were not transplanted). Baseline characteristics were similar between groups, all patients were transplanted with deceased donor, and the majority were induced with basiliximab. Mycophenolate group (n = 23) and sirolimus group (n = 21) had patient survival, and death censored graft survival respectively 95.7% and 100% for mycophenolate and 79.6% and 90.5% for the sirolimus without statistical differences. The incidence of acute rejection and kidney function over 12 months was similar between the groups. Infection of the surgical wound, delayed graft function and proteinuria were similar between groups. The total cholesterol and HDL cholesterol were higher in the sirolimus group. CMV infection occurred in 60.9% and 16.7% in mycophenolate and sirolimus group respectively. The relative risk of CMV were 3.54 [1, 2 - 10.3] times greater in mycophenolate group, p=0.004. Conclusion: In the sample of elderly kidney transplant combining tacrolimus and sirolimus in low doses was safe keeping similar rates of renal function at 12 months, rejection and graft survival. The main complications associated with sirolimus were similar except for a higher total cholesterol rates. The incidence of CMV was significantly lower in the sirolimus group.

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RESUMO Bruder R. Redução da Incidência de Citomegalovírus no esquema Sirolimo associado à Tacrolimo em paciente idoso transplantado renal. Tese (Doutorado). Faculdade de Medicina de Botucatu. Universidade Estadual Paulista, 2018. Introdução: O transplante renal é considerado uma opção de terapia renal substitutiva segura para pacientes acima de 60 anos, entretanto, não há consenso sobre o melhor esquema imunossupressor para o paciente transplantado renal idoso. Objetivo: Avaliar a incidência de infecção por citomegalovírus na combinação de tacrolimo e sirolimo em doses reduzidas comparada com a associação tacrolimo e micofenolato. Métodos: Estudo prospectivo randomizado de centro único comparando a combinação de tacrolimo e sirolimo em dose reduzida (grupo sirolimo) contra tacrolimo e micofenolato (grupo micofenolato). Foram incluídos todos os pacientes transplantados renais maiores de 60 anos. Foram avaliadas a incidência de infecção por citomegalovírus (CMV), a sobrevida do paciente e enxerto, taxas de rejeição e função renal em 12 meses de seguimento. Resultados: Foram randomizados 46 pacientes e analisados 44 casos (dois casos excluídos por não terem sido transplantados). As características basais dos grupos foram semelhantes sendo todos os casos transplantados com doador falecido e a maioria induzida com basiliximab. O grupo micofenolato (n=23) e o grupo sirolimo (n=21) apresentaram sobrevida do paciente e enxerto censurado óbito respectivamente de 95,7% e 100% para o micofenolato e 87,3% e 90,5% para o sirolimo sem diferenças estatísticas. A infecção por CMV ocorreu em 60,9% no grupo micofenolato e 16,7% no grupo sirolimo apresentando um risco relativo 3,54 [1,2 – 10,3] vezes maior no grupo micofenolato, p=0,004. A incidência de rejeição e função renal ao longo de 12 meses foi semelhante entre os grupos. A infecção de ferida operatória, retardo de função do enxerto e proteinúria foram semelhantes entre os grupos. O colesterol total e HDL colesterol foram maiores no grupo sirolimo. Conclusão: No grupo de transplantados renais idosos a combinação de tacrolimo e sirolimo em doses reduzidas resultou na redução de 40% da incidência de infecção por CMV. A função renal em 12 meses, taxa de rejeição e sobrevida do enxerto e paciente foram semelhantes.
ABSTRACT Bruder R. Reduced incidence of cytomegalovirus in the Sirolimus associated with tacrolimus in elderly kidney transplant patient. Tese (Doutorado). Faculdade de Medicina de Botucatu. Universidade Estadual Paulista, 2018. Introduction: Renal transplantation is considered safe for patients over 60 years, however, there is no consensus on the best immunosuppressive regimen in elderly. Objective: To evaluate the incidence of cytomegalovirus infection in the combination of tacrolimus and sirolimus in reduced doses compared to the combination tacrolimus and mycophenolate. Methods: A single-center prospective randomized study comparing the combination of tacrolimo and sirolimo in reduced dose (sirolimo group) against tacrolimo and mycophenolate (mycophenolate group). We included all kidney transplant patients over 60 years of age. The incidence of cytomegalovirus (CMV) infection, patient survival and graft, rejection rates and renal function were evaluated at 12 months of follow-up. Results: 46 patients were randomized and we analyzed 44 cases (two cases excluded because they were not transplanted). Baseline characteristics were similar between groups, all patients were transplanted with deceased donor, and the majority were induced with basiliximab. Mycophenolate group (n = 23) and sirolimo group (n = 21) had patient survival, and death censored graft survival respectively 95.7% and 100% for mycophenolate and 87,3% e 90,5% for the sirolimo without statistical differences. The incidence of CMV infection occurred in 60.9% and 16.7% in mycophenolate and sirolimo group respectively. The relative risk of CMV were 3.54 [1, 2 - 10.3] times greater in mycophenolate group, p=0.004. The incidence of acute rejection and kidney function over 12 months was similar between the groups. Infection of the surgical wound, delayed graft function and proteinuria were similar between groups. The total cholesterol and HDL cholesterol were higher in the sirolimo group. Conclusion: In the elderly renal transplant group, the combination of tacrolimus and sirolimus at reduced doses resulted in a 40% reduction in the incidence of CMV infection. Renal function at 12 months, rejection rate and graft and patient survival were similar.

Nous retracerons le parcours de la topologie dans l’enseignement lacanien : de la topologie algébrique, nous traiterons des figures topologiques (tore, bande de Mœbius, bouteille de Klein, cross-cap) pour en arriver à la topologie nodale dont le paradigme est le nœud borroméen. Nous considérerons alors les conséquences théoriques qu’elle implique : de l’inconscient freudien ou l’inconscient symbolique nous passerons à l’inconscient réel et l’une-bévue, et du symptôme nous envisagerons le sinthome et sa logique. Nous affinerons ainsi le double rapport du sujet au signifiant et à la jouissance mettant en avant l’importance du corps pris comme vivant. Pour ce faire, nous étudierons plus précisément le rapport du sujet au trou, manque fondamental qui le constitue, à la fois extérieur et intérieur. Nous verrons comment, dans son creux et dans ses bords, le sujet y loge sa singularité, son « x ». Nous l’articulerons à la clinique afin de révéler l’apport qu’elle représente dans la pratique
We will trace the course of topology in Lacan’s teaching: from algebraic topology, where we will deal with topological surfaces (torus, Moebius strip, Klein bottle, cross-cap) we will reach topology whose paradigm is the Borromean knot. We will then consider the theoretical consequences implied: from the Freudian unconscious or symbolic unconscious we will move to the real unconscious and the une-bévue, and from the symptom we will consider the sinthome and its logic. We will refine the dual relationship of the subject to signifier and Jouissance, and highlight the importance of the body as living. To do this, we will study more precisely the relationship of the subject to the hole, a fundamental lack that constitutes him, both exterior and interior. We will see how, in its hollow and its edges, the subject lodges its singularity, its "x". We will link it to clinic to reveal the contribution of topology in practice

Orientador: Luis Gustavo Modelli de Andrade
Resumo: Introdução: O transplante renal é considerado uma opção de terapia renal substitutiva segura para pacientes acima de 60 anos, entretanto, não há consenso sobre o melhor esquema imunossupressor para o paciente transplantado renal idoso. Objetivo: Avaliar a eficácia e segurança da combinação de tacrolimus e sirolimus em doses reduzidas comparada com a associação tacrolimus e micofenolato. Métodos: Estudo prospectivo randomizado de centro único comparando a combinação de tacrolimus e sirolimus em dose reduzida (grupo sirolimus) contra tacrolimus e micofenolato (grupo micofenolato). Foram incluídos todos os pacientes transplantados renais maiores de 60 anos. Foram avaliadas a sobrevida do paciente e enxerto, taxas de rejeição, função renal e incidência de infecção por citomegalovírus (CMV) em 12 meses de seguimento. Resultados: Foram randomizados 46 pacientes e analisados 44 casos (dois casos excluídos por não terem sido transplantados). As características basais dos grupos foram semelhantes sendo todos os casos transplantados com doador falecido e a maioria induzida com basiliximabe. O grupo micofenolato (n=23) e o grupo sirolimus (n=21) apresentaram sobrevida do paciente e enxerto censurado óbito respectivamente de 95,7% e 100% para o micofenolato e 79,6% e 90,5% para o sirolimus sem diferenças estatísticas. A incidência de rejeição e função renal ao longo de 12 meses foi semelhante entre os grupos. A infecção de ferida operatória, retardo de função do enxerto e proteinúria for... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Introduction: Renal transplantation is considered safe for patients over 60 years, however, there is no consensus on the best immunosuppressive regimen in elderly. Objective: To evaluate the combination of tacrolimus and sirolimus in reduced dose in renal function comparing the combination tacrolimus and mycophenolate. Methods: A single-center prospective randomized study comparing the combination of tacrolimus and sirolimus in reduced dose (sirolimus group) against tacrolimus and mycophenolate (mycophenolate group). We included all kidney transplant patients over 60 years of age. We evaluated patient survival, biopsy prove acute rejection, renal function and incidence of cytomegalovirus (CMV) at 12 months of follow-up. Results: 46 patients were randomized and we analyzed 44 cases (two cases excluded because they were not transplanted). Baseline characteristics were similar between groups, all patients were transplanted with deceased donor, and the majority were induced with basiliximab. Mycophenolate group (n = 23) and sirolimus group (n = 21) had patient survival, and death censored graft survival respectively 95.7% and 100% for mycophenolate and 79.6% and 90.5% for the sirolimus without statistical differences. The incidence of acute rejection and kidney function over 12 months was similar between the groups. Infection of the surgical wound, delayed graft function and proteinuria were similar between groups. The total cholesterol and HDL cholesterol were higher in the siro... (Complete abstract click electronic access below)
Mestre

The Internet presents a constantly evolving frontier for criminology and policing, especially in relation to online predators – paedophiles operating within the Internet for safer access to children, child pornography and networking opportunities with other online predators. The goals of this qualitative study are to undertake behavioural research – identify personality types and archetypes of online predators and compare and contrast them with behavioural profiles and other psychological research on offline paedophiles and sex offenders. It is also an endeavour to gather intelligence on the technological utilisation of online predators and conduct observational research on the social structures of online predator communities. These goals were achieved through the covert monitoring and logging of public activity within four Internet Relay Chat(rooms) (IRC) themed around child sexual abuse and which were located on the Undernet network. Five days of monitoring was conducted on these four chatrooms between Wednesday 1 to Sunday 5 April 2009; this raw data was collated and analysed. The analysis identified four personality types – the gentleman predator, the sadist, the businessman and the pretender – and eight archetypes consisting of the groomers, dealers, negotiators, roleplayers, networkers, chat requestors, posters and travellers. The characteristics and traits of these personality types and archetypes, which were extracted from the literature dealing with offline paedophiles and sex offenders, are detailed and contrasted against the online sexual predators identified within the chatrooms, revealing many similarities and interesting differences particularly with the businessman and pretender personality types. These personality types and archetypes were illustrated by selecting users who displayed the appropriate characteristics and tracking them through the four chatrooms, revealing intelligence data on the use of proxies servers – especially via the Tor software – and other security strategies such as Undernet’s host masking service. Name and age changes, which is used as a potential sexual grooming tactic was also revealed through the use of Analyst’s Notebook software and information on ISP information revealed the likelihood that many online predators were not using any safety mechanism and relying on the anonymity of the Internet. The activities of these online predators were analysed, especially in regards to child sexual grooming and the ‘posting’ of child pornography, which revealed a few of the methods in which online predators utilised new Internet technologies to sexually groom and abuse children – using technologies such as instant messengers, webcams and microphones – as well as store and disseminate illegal materials on image sharing websites and peer-to-peer software such as Gigatribe. Analysis of the social structures of the chatrooms was also carried out and the community functions and characteristics of each chatroom explored. The findings of this research have indicated several opportunities for further research. As a result of this research, recommendations are given on policy, prevention and response strategies with regards to online predators.

Providing a socio-legal analysis of the issues, expert evidence and judgment in Reay and Hope v BNFL plc., the thesis offers an insight into the complexity of the toxic tort. Starting with an overview of the history of Sellafield, the thesis reflects on the scientific and epidemiological concerns surrounding the link between childhood cancer and nuclear installations. Drawing on scientific knowledge and epistemological considerations, the thesis moves on to the difficulties of verifying causation in science and the problems of establishing causation in law. Outlining the role of the expert witness and scientific expert evidence, the thesis proceeds with a case analysis, before broaching the thorny issue of judicial decision making and in particular, the difference between the 'discovery' and 'justification' process. Moving on to the Judgment in Reay and Hope, attention is given to the potential application of probability theory to the judicial decision making process. Lasting just short of one hundred days and including the testimony of numerous scientific experts, Reay and Hope marked new ground in a number of ways; it was the first personal injury claim to test the concept of genetic damage from radiation; the only time that a Queen's Bench Division Judge had been allocated a full-time judicial assistant; and one of the first trials to endorse a satellite video link for examination of international expert witnesses. As far as judicial management is concerned, the case was a forerunner in having Counsels' Opening Statements in writing in advance of the trial, as well as having written daily submissions of key issues from plaintiffs and defendants upon conclusion of oral evidence. The circumstances that led to the trial relate to events in excess of thirty to forty years ago when the fathers of Dorothy Reay and Viven Hope were employed by the Defendants and their predecessors (the United Kingdom Atomic Energy Authority) as fitters for the Sellafield Plant. Intrinsic to the litigation was whether paternal preconception irradiation caused or materially contributed to a predisposition to cancer leading to Dorothy's death from leukaemia and Vivien Hope's non-Hodgkin's lymphoma. As a consequence of the various statutory provisions, the Plaintiffs did not need to prove negligence on the part of the Defendants. In order to succeed the Plaintiffs had to prove on the balance of probabilities that radiation from Sellafield was a material contributory cause of the Plaintiffs' disease. The fundamental issue therefore was causation. In addition to the case analysis, two pieces of empirical research were conducted for the purposes of this thesis. The first, a Social Survey (consisting of thirty four questions) was circulated to 160 members of the Academy of Experts (quantitative research); the second, a letter, involved written communication with sixty five judges from the Queen's Bench Division of the High Court (qualitative research). Underlying this socio-legal case analysis are fundamental questions with regard to existing legal principles, liability and judicial decision making.

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Introdu??o: Existem relatos de maior sobrevida em pacientes do g?nero feminino, portadoras de carcinoma br?nquico n?o-pequenas c?lulas (CBNPC). Trabalho preliminar, realizado no Hospital S?o Lucas da PUCRS (HSLPUCRS), mostrou resultados semelhantes. O objetivo deste trabalho foi avaliar do papel do g?nero em rela??o ? sobrevida em pacientes com CBNPC. Metodologia: Em desenho tipo coorte retrospectiva, foi avaliada a sobrevida de 478 pacientes com CBNPC tratados cirurgicamente com inten??o curativa, conforme estadiamento, no HSL-PUCRS, entre 1990 e 2009. A sobrevida foi analisada atrav?s do m?todo Kaplan-Meier. O modelo de regress?o de Cox foi utilizado para avaliar potenciais fatores de confus?o. Resultados: A sobrevida ap?s 5 anos de acompanhamento foi de 55,6% e 38,8% para mulheres e homens, respectivamente, em an?lise sem censura dos pacientes com perda de acompanhamento (P=0,005). Em an?lise de pior cen?rio as taxas foram de 25,5% e 19,4% para mulheres e homens, respectivamente. Ap?s ajuste para v?rios fatores (idade, histologia do tumor, estadiamento, extens?o da cirurgia, anemia e complica??es p?s-operat?ria), o efeito protetor do g?nero feminino persistiu apenas para os pacientes em est?gio I. O risco relativo em homens em est?gio I foi de 1,95 (IC95%: 1,16 a 3.27, P=0,012). Conclus?o: Os resultados aqui encontrados mostram que o g?nero feminino foi fator protetor, em rela??o ? mortalidade, em pacientes com CBNPC submetidos ? cirurgia com inten??o curativa, em est?gio I, quando comparado aos homens. Este efeito n?o se manteve nos pacientes nos est?gios ≥II.