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1
Sarbaz, Said Asif, Satish Kumar, Suresh Kumar, Kautilya Chaudhary, Jogander Kumar, and Vinod Kumar Malik. "Impact of Nitrogen Nutrition through Organic and Inorganic Sources of Fertilizer on Growth Phenology and Yield of Wheat (Triticum aestivum L.)." International Journal of Advances in Agricultural Science and Technology 8, no. 12 (December 30, 2021): 1–10. http://dx.doi.org/10.47856/ijaast.2021.v08i12.001.
Повний текст джерелаАнотація:
The field experiment was conducted at wheat research farm of CCS Haryana Agriculture University during Rabi season of 2019-20 to study nitrogen nutrition through organic and inorganic source of fertilizer on growth phenology, yield and quality of wheat (Triticum aestivum L.) The experiment was laid out in randomized block design with three replications containing 16 treatments combination i.e T1-Control; T2-100% RDN through urea; T3- 100% RDN through FYM; T4-100% RDN through vermicompost; T5-50% RDN through urea+ 50% RDN through FYM; T6-50% RDN through urea+ 50% RDN through vermicompost; T7-25% RDN through urea+ 75% RDN through FYM; T8-25% RDN through urea 75% RDN through vermicompost; T9-100% RDN through urea + Azotobacter; T10-100% RDN through FYM + Azotobacter; T11-100% RDN through vermicompost + Azotobacter; T12-50% RDN through urea+ 50% RDN through FYM + Azotobacter; T13-50% RDN through urea+ 50% RDN through vermicompost + Azotobacter; T14-25% RDN through urea+ 75% RDN through FYM + Azotobacter; T15-25% RDN through urea+ 75% RDN through vermicompost + Azotobacter; T16- Azotobacter. Treatment T9, 100% nitrogen nutrition through chemical fertilizer (urea) with seed treatment of Azotobacter has taken significantly maximum days to emergence (5.3). Days taken to 50% spike emergence (94.7) and days taken to maturity (148.0) respectively. Similarly T9 had significantly higher grain yield (5640 kg/ha), hectoliter weight (83.167 kg/ha), grain appearance score (7.933 scale/10) and protein content (12.90 %) of wheat during the research period respectively.
2
Gao, Juan, Ian B. Denys, Jane Sutphen, Luis Del Valle, and Daniel R. Kapusta. "3326 Radiofrequency Renal Denervation Prevents Further Progression of Hypertension and Decreases Renal Medullary Fibrosis in One-year-old Spontaneously Hypertensive Rats (SHR)." Journal of Clinical and Translational Science 3, s1 (March 2019): 19. http://dx.doi.org/10.1017/cts.2019.47.
Повний текст джерелаАнотація:
OBJECTIVES/SPECIFIC AIMS: We have reported that radiofrequency renal denervation (RF-RDN) in SHR at 20-weeks of age, decreased blood pressure (BP) and fibrosis in kidney cortex and medulla when rats were sacrificed at 6 months. However, whether RF-RDN can have similar benefits in older rats remains unknown. This study examined whether performing RF-RDN in older rats also has a beneficial effect on BP and renal fibrosis. METHODS/STUDY POPULATION: Baseline systolic and diastolic BP (SBP/DPB) was measured (telemetry) in nine-month-old SHR and Wistar Kyoto rats (WKY). Groups of rats then received bilateral RF-RDN or Sham-RDN (SHR-RDN, n=9; SHR-Sham, n=10; WKY-RDN, n=5; WKY-Sham, n=8). Rats were then sacrificed at 12-months of age. Kidneys were harvested, sectioned, and assessed for fibrosis by Masson’s trichrome stain. A pathologist, who was blinded to treatment groups, evaluated each kidney section for fibrosis. RESULTS/ANTICIPATED RESULTS: Compared to SHR with Sham-RDN, RF-RDN prevented a further increase in systolic and diastolic BP from baseline (9-month) in SHR as they aged to 12-months (SHR-Sham mmHg: 9-month 193±4/127±4; 12-month 207±3/142±5; SHR-RDN mmHg: 9-month 197±3/132±2; 12-month 197±4/132±3). RF-RDN did not alter SBP or DBP in aged WKY. One-year-old SHR with prior Sham-RDN showed extensive renal fibrosis in kidney cortex and medulla. In contrast, RF-RDN significantly decreased renal fibrosis in the medulla, but not cortex. There was no fibrosis in kidneys of age matched WKY. DISCUSSION/SIGNIFICANCE OF IMPACT: These findings suggest that RF-RDN may be a potential therapy for halting progression of hypertension and decreasing medullary fibrosis in the aged population.
3
Guo, Zhiqin, Yufeng Chen, Shuoxian Chen, Chao Liu, Shaonan Li, and Pingan Chen. "Renal Denervation Mitigated Fecal Microbiota Aberrations in Rats with Chronic Heart Failure." Evidence-Based Complementary and Alternative Medicine 2021 (October 15, 2021): 1–17. http://dx.doi.org/10.1155/2021/1697004.
Повний текст джерелаАнотація:
Background. Changes in the composition and diversity of gut microbiota, which can be altered by autonomic nerve activity, contribute to the development of heart failure (HF). Renal denervation (RDN) can improve cardiac function by reducing sympathetic nerve activity. However, whether the beneficial role of RDN on HF is related to gut microbiota is unknown. Methods. Thirty rats were assigned to a control, HF (with induced transverse aortic constriction (TAC)), RDN (with RDN induced 10 weeks after TAC), Nog (HF rats with Nogo-P4-administered 8 weeks after RDN), and NEP (HF rats with NEP1-40-administered 8 weeks after RDN) group. Then, 16SrRNA amplicon sequencing and analyses of fecal samples were performed. Results. Beta diversity analyses revealed that compared to the HF group, the RDN, Nog, and NEP groups clustered closer to the control group. The Firmicutes/Bacteroidetes ratio was reduced in the HF group (1.59) compared with the control group (3.21) and was significantly decreased compared to the Nog (7.19), RDN (6.20), and NEP (4.42) groups. At the genus level, the HF group showed decreased abundances of Lactobacillus and Alistipes and increased abundances of Bacteroides and Clostridium compared with the control group. The abundances of Lactobacillus and Alistipes were increased, and those of Bacteroides and Clostridium were decreased in the RDN, Nog, and NEP groups compared to the HF group. However, no differences were observed between the three groups that underwent RDN. The microbial function showed the same tendency. Conclusions. RDN reversed the abnormal changes in the gut microbiome in HF rats. Inhibition of reinnervation after RDN did not affect intestinal bacteria.
4
Ziakas, Antonios, Dimitrios Petroglou, Efstratios Moralidis, Konstantinos Tsioufis, Mihalis Doumas, Elena Argiriadou, Christos Savopoulos, et al. "Initial Experience with Renal Denervation for the Treatment of Resistant Hypertension - The Utility of Novel Anesthetics and Metaiodobenzylguanidine Scintigraphy (MIBG)." Open Cardiovascular Medicine Journal 10, no. 1 (July 29, 2016): 163–70. http://dx.doi.org/10.2174/1874192401610010163.
Повний текст джерелаАнотація:
Background: The Symplicity-HTN 3 trial failed to show significant difference in blood pressure (BP) lowering between patients undergoing catheter-based renal denervation (RDN) and the sham-procedure arm of the study. However, there is still optimism about the role of RDN in the treatment of resistant hypertension, because identification of patients with increased sympathetic activity thus being good RDN responders, improvements in the RDN procedure and new technology RDN catheters are all expected to lead to better RDN results. We present our initial experience with RDN for the treatment of resistant hypertension, and the utility of novel anesthetics and cardiac 123I-metaiodobenzylguanidine scintigraphy (123I-MIBG). Methods and Results: Seven patients with resistant hypertension underwent RDN and were followed up for 6 months. MIBG was performed before RDN, in order to estimate sympathetic activity and predict the response to RDN. All patients were sedated with dexmedetomidine and remifentanil during RDN. All patients tolerated the procedure well, were hemodynamically stable and their peri-procedural pain was effectively controlled. A median of 7.6 ± 2.1 and 6 ± 1.4 ablations were delivered in the right and left renal artery respectively, making an average of 6.8 burns per artery. No peri-procedural or late complications - adverse events (local or systematic) occurred. At 6 months, mean reduction in office BP was -26.0/-16.3 mmHg (p=0.004/p=0.02), while mean reduction in ambulatory BP was -12.3/-9.2 mmHg (p=0.118/p=0.045). One patient (14.3%) was a non-responder. None of the cardiac 123I-MIBG imaging indexes(early and late heart-to-mediastinum (H/M) count density ratio, washout rate (WR) of the tracer from the myocardium) were different between responders and non-responders. Conclusion: Patients with resistant hypertension who underwent RDN in our department had a significant reduction in BP 6 months after the intervention. 123I-MIBG was not useful in predicting RDN response. Dexmedetomidine and remifentanil provided sufficient patient comfort during the procedure, allowing an adequate number of ablations per renal artery to be performed, and this could probably lead to improved RDN results.
5
Vakhrushev, Aleksandr D., Heber Ivan Condori Leandro, Natalia S. Goncharova, Lev E. Korobchenko, Lubov B. Mitrofanova, Dmitry S. Lebedev, and Evgeny N. Mikhaylov. "Extended Renal Artery Denervation Is Associated with Artery Wall Lesions and Acute Systemic and Pulmonary Hemodynamic Changes: A Sham-Controlled Experimental Study." Cardiovascular Therapeutics 2020 (October 28, 2020): 1–8. http://dx.doi.org/10.1155/2020/8859663.
Повний текст джерелаАнотація:
Objectives. We sought to assess acute changes in systemic and pulmonary hemodynamics and microscopic artery lesions following extended renal artery denervation (RDN). Background. RDN has been proposed to reduce sympathetic nervous system hyperactivation. Although the effects of RDN on systemic circulation and overall sympathetic activity have been studied, data on the impact of RDN on pulmonary hemodynamics is lacking. Methods. The study comprised 13 normotensive Landrace pigs. After randomization, 7 animals were allocated to the group of bilateral RDN and 6 animals to the group of a sham procedure (SHAM). Hemodynamic measures, cannulation, and balloon-based occlusion of the renal arteries were performed in both groups. In the RDN group, radiofrequency ablation was performed in all available arteries and their segments. An autopsy study of the renal arteries was carried out in both groups. Results. The analysis was performed on 12 pigs (6 in either group) since pulmonary thromboembolism occurred in one case. A statistically significant drop in the mean diastolic pulmonary artery pressure (PAP) was detected in the RDN group when compared with the SHAM group (change by 13.0 ± 4.4 and 10.0 ± 3.0 mmHg , correspondingly; P = 0.04 ). In 5 out of 6 pigs in the RDN group, a significant decrease in systemic systolic blood pressure was found, when compared with baseline ( 98.8 ± 17.8 vs. 90.2 ± 12.6 mmHg , P = 0.04 ), and a lower mean pulmonary vascular resistance (PVR) ( 291.0 ± 77.4 vs. 228.5 ± 63.8 dyn ∗ sec ∗ c m − 5 , P = 0.03 ) after ablation was found. Artery dissections were found in both groups, with prevalence in animals after RDN. Conclusions. Extensive RDN leads to a rapid and significant decrease in PAP. In the majority of cases, RDN is associated with an acute lowering of systolic blood pressure and PVR. Extended RDN is associated with artery wall lesions and thrombus formation underdiagnosed by angiography.
6
Hoque, Tahsina Sharmin, Farhana Akter, and Md Rafiqul Islam. "Residual effects of different green manures on the growth and yield of wheat." Asian Journal of Medical and Biological Research 2, no. 4 (January 23, 2017): 624–30. http://dx.doi.org/10.3329/ajmbr.v2i4.31006.
Повний текст джерелаАнотація:
Green manures can enrich soils with organic matter and nitrogen. An experiment was conducted at the Soil Science Field Laboratory of Bangladesh Agricultural University, Mymensingh, Bangladesh to evaluate the residual effects of different green manures on the growth and yield of wheat (BARI Gom-26). The experiment containing nine treatments were laid out in a randomized complete block design with three replications. The treatments were T1 [No green manure + 100% Recommended dose of nitrogen (RDN)], T2 (Sesbania aculeata + 75% RDN), T3 (Sesbania aculeata + 50% RDN), T4 (Sesbania rostrata + 75% RDN), T5 (Sesbania rostrata + 50% RDN), T6 (Vigna radiata + 75% RDN), T7 (Vigna radiata + 50% RDN), T8 (Vigna mungo + 75% RDN), and T9 (Vigna mungo + 50% RDN). Residual effects of green manures with RDN significantly increased the yield attributes as well as grain and straw yields of wheat. Further, green manures exerted significant residual effects on grain, straw and total N uptake of wheat. Among various treatments with green manures, the performance of T4 (Sesbania rostrata + 75% RDN) was the best as it produced the highest grain yield (4.28 t ha-1), straw yield (4.74 t ha-1) and total N uptake (108.02 kg ha-1). The use of green manures slightly increased the organic matter content, total N and available P, K, and S contents of the post-harvest soils. As regards to the contribution of various green manures on yield contributing characters and yield of wheat, performances of two Sesbania species viz., S. aculeata and S. rostrata in association with 75% N fertilizer were effective.Asian J. Med. Biol. Res. December 2016, 2(4): 624-630
7
Edwards, Jessica K. "Microanatomy impacts on RDN." Nature Reviews Nephrology 11, no. 7 (May 19, 2015): 387. http://dx.doi.org/10.1038/nrneph.2015.80.
Повний текст джерела
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Gao, Juan, Ian B. Denys, Luis Del Valle, Mihran V. Naljayan, and Daniel R. Kapusta. "2267 Radiofrequency renal denervation attenuates kidney fibrosis in spontaneously hypertensive rats." Journal of Clinical and Translational Science 2, S1 (June 2018): 25. http://dx.doi.org/10.1017/cts.2018.113.
Повний текст джерелаАнотація:
OBJECTIVES/SPECIFIC AIMS: The goal of this study was to investigate whether RF-RDN attenuates renal fibrosis and inflammation in SHR with established hypertension. METHODS/STUDY POPULATION: Twenty-two-week-old SHR received bilateral RF-RDN or Sham-RDN (Biosense Webster Stockert 70 generator and RF-probe). Four weeks later, SHR were sacrificed and paraffin sections of kidneys were stained for fibrosis by Masson’s trichrome staining. Kidney tissue were homogenized for measurement of cytokines levels by ELISA. RESULTS/ANTICIPATED RESULTS: The results showed that Sham-RDN treated SHR had extensive fibrosis as demonstrated by moderate thickening of Bowman’s capsule, collagen deposition in glomerulus, extensive tubulointerstitial fibrosis, and segmental glomerulosclerosis. In contrast, RF-RDN significantly reduced each of these pathological components of fibrosis in kidney cortex and medulla as compared with Sham-RDN treated kidneys. In other studies, RF-RDN decreased B cells, CD4+ T cells, and CD8+ T cells in the kidney of SHR as measured by flow cytometry. Meanwhile, kidney tissue levels of IL-17, INF-γ, MIP-3a, TNF-α, and TGF-β were decreased as compared with respective levels in Sham-RDN. DISCUSSION/SIGNIFICANCE OF IMPACT: Together, these findings demonstrate that removal of the influence of heightened renal sympathetic activity by RF-RDN decreases kidney inflammatory markers and attenuates renal fibrosis in hypertensive SHR.
9
Singh, Reetu R., Zoe M. McArdle, Lindsea C. Booth, Clive N. May, Geoff A. Head, Karen M. Moritz, Markus P. Schlaich, and Kate M. Denton. "Increase in Bioavailability of Nitric Oxide After Renal Denervation Improves Kidney Function in Sheep With Hypertensive Kidney Disease." Hypertension 77, no. 4 (April 2021): 1299–310. http://dx.doi.org/10.1161/hypertensionaha.120.16718.
Повний текст джерелаАнотація:
Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in hypertensive chronic kidney disease (CKD). In sheep with hypertensive CKD and NO deficiency, renal denervation (RDN) reduces blood pressure and improves kidney function (glomerular filtration rate). We hypothesized that this improvement in glomerular filtration rate after RDN is associated with increased NO bioavailability. In this study, glomerular filtration rate response to systemic inhibition of NOS (NO synthase) was examined in healthy and CKD sheep at 2 and 30 months after a sham (intact nerves) or RDN procedure. Basal urinary total nitrate (nitrate+nitrite) excretion was examined at 2 and 30 months, and kidney protein expression of endothelial and neuronal NOS was assessed at 30 months. Urinary nitrate+nitrite in CKD-RDN and healthy sheep was ≈50% to 70% greater than in CKD-intact. During NOS inhibition, the fall in glomerular filtration rate in CKD-RDN sheep was ≈20% greater than in CKD-intact. These effects in CKD-RDN sheep were similar to those in healthy sheep. Endothelial NOS protein expression was lower in CKD-intact sheep compared with healthy sheep and compared with CKD-RDN. In summary, RDN normalizes NO bioavailability and restores contribution of NO to renal hemodynamics in CKD. These changes may promote improvements in kidney function and sustained blood pressure lowering after RDN in hypertensive CKD.
10
Singh, Reetu R., Zoe McArdle, Lindsea C. Booth, Clive N. May, Geoff A. Head, Karen M. Moritz, Markus P. Schlaich, and Kate M. Denton. "Renal Denervation in Combination With Angiotensin Receptor Blockade Prolongs Blood Pressure Trough During Hemorrhage." Hypertension 79, no. 1 (January 2022): 261–70. http://dx.doi.org/10.1161/hypertensionaha.121.18354.
Повний текст джерелаАнотація:
Majority of patients with hypertension and chronic kidney disease (CKD) undergoing renal denervation (RDN) are maintained on antihypertensive medication. However, RDN may impair compensatory responses to hypotension induced by blood loss. Therefore, continuation of antihypertensive medications in denervated patients may exacerbate hypotensive episodes. This study examined whether antihypertensive medication compromised hemodynamic responses to blood loss in normotensive (control) sheep and in sheep with hypertensive CKD at 30 months after RDN (control-RDN, CKD-RDN) or sham (control-intact, CKD-intact) procedure. CKD-RDN sheep had lower basal blood pressure (BP; ≈9 mm Hg) and higher basal renal blood flow (≈38%) than CKD-intact. Candesartan lowered BP and increased renal blood flow in all groups. 10% loss of blood volume alone caused a modest fall in BP (≈6–8 mm Hg) in all groups but did not affect the recovery of BP. 10% loss of blood volume in the presence of candesartan prolonged the time at trough BP by 9 minutes and attenuated the fall in renal blood flow in the CKD-RDN group compared with CKD-intact. Candesartan in combination with RDN prolonged trough BP and attenuated renal hemodynamic responses to blood loss. To minimize the risk of hypotension-mediated organ damage, patients with RDN maintained on antihypertensive medications may require closer monitoring when undergoing surgery or experiencing traumatic blood loss.
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Wang, Kai, Dasheng Lu, Bin Zhang, Shengchan Wang, Qian Liu, Qi Zhang, Jie Geng, and Qijun Shan. "Renal Denervation Attenuates Multi-Organ Fibrosis and Improves Vascular Remodeling in Rats with Transverse Aortic Constriction Induced Cardiomyopathy." Cellular Physiology and Biochemistry 40, no. 3-4 (2016): 465–76. http://dx.doi.org/10.1159/000452561.
Повний текст джерелаАнотація:
Background/Aims: To investigate the effects of renal denervation (RDN) on multi-organ fibrosis and vascular remodeling in cardiomyopathy. Methods: Thirty-six male Sprague-Dawley rats underwent transverse aortic constriction (TAC). Five weeks later, 28 surviving TAC rats were randomly assigned to three groups: (1) RDN, (2) Sham, (3) Carvedilol. Six male Sham TAC rats served as the Control. Ten weeks after TAC, samples were collected. Results: TAC rats showed an increased diastolic interventricular septal thickness at week 5. At 10 weeks, Masson staining showed that left ventricular and renal glomerular fibrosis were significantly reduced in RDN compared with Sham group. In comparison to Sham group, hepatic perivascular fibrosis was attenuated in both RDN and Carvedilol group, so were the media thickness and the media/lumen of aorta. The plasma levels of B-type natriuretic peptide (BNP), Cystatin C (Cys-C), Alanine Transaminase, angiotensin II (Ang II), transforming growth factor beta 1 (TGF-β1), and malondialdehyde increased, and total superoxide dismutase (T-SOD) decreased in Sham but not in RDN group, compared with Control group. Both RDN and Carvedilol reduced the Cys-C and TGF-β1 levels, and restored T-SOD concentration, compared with Sham group. While only RDN lowered the plasma levels of BNP and Ang II. No significant effects of RDN on blood pressure (BP) and heart rate (HR) were oberved. Conclusions: RDN can attenuate multi-organ fibrosis and improve vascular remodeling independent of BP and HR change in TAC-induced cardiomyopathy. These effects of RDN may be associated with the direct inhibition of renin-angiotensin-aldosterone system and oxidative stress.
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Booth, Lindsea C., R. Anethra U. de Silva, Roberto B. Pontes, Song T. Yao, Sally G. Hood, Yugeesh R. Lankadeva, Junko Kosaka, et al. "Renal, Cardiac, and Autonomic Effects of Catheter-Based Renal Denervation in Ovine Heart Failure." Hypertension 78, no. 3 (September 2021): 706–15. http://dx.doi.org/10.1161/hypertensionaha.120.16054.
Повний текст джерелаАнотація:
A growing number of clinical studies suggest that in heart failure renal denervation (RDN) has beneficial effects on the autonomic control of the heart. There is also experimental evidence that surgical RDN improves sodium handling and clearance in heart failure. The aim of this study was to determine the effects of catheter-based RDN on the sympathetic and parasympathetic control of the heart, and salt and water handling capacity of the kidneys, in sheep with established heart failure. A randomized, controlled study was conducted in 10 sheep with heart failure (ejection fraction<40%) induced by rapid ventricular pacing. Sheep underwent either bilateral RDN using the Symplicity denervation system or sham denervation and were studied 1 and 6 weeks after RDN. In established ovine heart failure, at 6 weeks after catheter-based RDN, heart rate significantly decreased, estimates of resting and maximal parasympathetic control of heart rate increased, and cardiac sympathetic nerve activity decreased. Compared with sham denervation, there was an increase in the resting sodium and water excretion 6 weeks after catheter-RDN and an improved ability of the kidneys to excrete a nonhypertensive saline load. After catheter-based RDN, renal norepinephrine levels were reduced by 70% compared with sham denervation. In established heart failure, RDN induced a beneficial shift in both arms of the autonomic nervous control of the heart and improved the ability of the kidneys to excrete sodium and water. Thus, effective catheter-based RDN may be beneficial to both the heart and kidneys in heart failure.
13
Zhang, Bin, Xiaorong Li, Chu Chen, Wanying Jiang, Dasheng Lu, Qian Liu, Kai Wang, et al. "Renal Denervation Effects on Myocardial Fibrosis and Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy." Cellular Physiology and Biochemistry 46, no. 6 (2018): 2471–79. http://dx.doi.org/10.1159/000489653.
Повний текст джерелаАнотація:
Background/Aims: To investigate the impact of renal denervation (RDN) on myocardial fibrosis and ventricular arrhythmias (VAs) in rats with ischemic cardiomyopathy. Methods: An ischemic cardiomyopathy model was reproduced with myocardial infarction (MI) in adult Sprague–Dawley male rats. The RDN/Sham-RDN procedure was performed at 2 weeks after MI. Sham-MI and sham-RDN rats served as the control group. At 4 weeks after RDN, programmed electrical stimulation (PES) was used to induce VAs, including ventricular tachycardia and ventricular fibrillation, in all 3 groups (MI+RDN, MI, and control groups). At the end of PES, heart and kidney samples were harvested. Immunofluorescence labeling was used to investigate the distribution of connexin 43 (Cx43) in the infarcted border zone. Masson’s trichrome stain was adopted to determine the degree of cardiac fibrosis. Western blotting was performed to identify the expression of transforming growth factor beta 1 (TGF-β1), α-smooth muscle actin (α-SMA), and Cx43. An enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of B-type natriuretic peptide (BNP) and the amino-terminal pro-peptides of type I and III collagen (PINP and PIIINP, respectively) and the expression level of renal norepinephrine. Results: Compared with the MI group, RDN significantly decreased the inducibility of VAs (MI+RDN 3/8 rats vs. MI 8/9 rats, P < 0.05; control 1/8 rats) with PES, reduced myocardial fibrosis estimated by collagen volume fraction (MI+RDN 31.10 ± 3.97% vs. MI 54.80 ± 16.39%, P < 0.001; control 4.41 ± 0.92% ), suppressed TGF-β1 (P < 0.01) and α-SMA (P < 0.001) levels, and attenuated both PINP (MI+RDN 41.44 ± 10.10 ng/mL vs. MI 95.49 ± 24.83 ng/mL, P < 0.001; control 11.90 ± 4.96 ng/mL) and PIIINP (MI+RDN 82.12 ± 30.79 ng/mL vs. MI 124.60 ± 26.64 ng/mL, P < 0.05; control 64.69 ± 23.84 ng/mL) levels. Moreover, RDN reversed the abnormal myocardial distribution of Cx43 and its reduction by MI damage (P < 0.01). Conclusions: RDN reduced myocardial fibrosis and suppressed VAs in a rat model of ischemic cardiomyopathy.
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Mangaraj, Satyabrata, Rabindra Kumar Paikaray, Sagar Maitra, Shriram Ratan Pradhan, Lalita Mohan Garnayak, Manoranjan Satapathy, Barsita Swain, et al. "Integrated Nutrient Management Improves the Growth and Yield of Rice and Greengram in a Rice—Greengram Cropping System under the Coastal Plain Agro-Climatic Condition." Plants 11, no. 1 (January 5, 2022): 142. http://dx.doi.org/10.3390/plants11010142.
Повний текст джерелаАнотація:
Continuous mono-cropping of rice has resulted in decline or stagnation of yield output due to the occurrence of multiple nutrient deficiencies and worsening of soil physicochemical properties accompanying increased pressure of insect pests and diseases. The basic concept of integrated nutrient management (INM) is maintenance or adjustment of soil fertility and supply of plant nutrients to an optimum level for sustaining the desired crop productivity through optimisation of benefits from all possible sources of plant nutrients in an integrated way. Augmenting a rice-based cropping system with pulses is a prevalent and indigenous cropping system under rainfed conditions. Considering the above facts, experiments were conducted to evaluate the impacts of integrated nutrient management on productivity of aromatic rice–greengram cropping system and nutrient balance of the post-harvest soil for agricultural sustainability under rainfed conditions in two consecutive years (2017–2018 and 2018–2019) with six main plots and three subplots. The experimental findings revealed that the treatment comprised of 50% recommended dose of fertiliser (RDF) through chemicals + 50% recommended dose of nitrogen (RDN) through farmyard manure (FYM) increased the plant height, tillers, dry matter accumulation, leaf area and leaf area duration, and yield parameters in short grain aromatic rice. Similarly, preceding application of 50% RDF + 50% RDN through FYM to rice and further application 75% RDF + Rhizobium+ phosphate solubilizing bacteria (PSB) to greengram increased the growth characteristics and yield parameters—such as pods/plant, seeds/pod, grain yield, stover yield, and harvest index—in greengram. It was concluded that the treatment consisting of 50% RDF (chemical fertiliser) + 50% RDN (FYM) to rice and 75% RDF + Rhizobium + PSB to greengram increased the productivity of the rice–greengram cropping system. Furthermore, the adoption of INM has positively impacted post-harvest soil nutrient balance.
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Sitkova, E. S., V. F. Mordovin, S. E. Pekarsky, T. M. Ripp, A. Yu Falkovskaya, V. A. Lichikaki, I. V. Zyubanova, et al. "Distal renal denervation: cardioprotection in patients with resistant hypertension." Cardiovascular Therapy and Prevention 19, no. 4 (September 5, 2020): 2225. http://dx.doi.org/10.15829/1728-8800-2019-2225.
Повний текст джерелаАнотація:
Aim. To study the effectiveness of using the anatomically optimized distal renal denervation (RDN) in comparison with the standard approach for reducing myocardial damage and left ventricular (LV) hypertrophy in patients with resistant hypertension (HTN).Material and methods. The randomized double-blind study of the efficacy and safety of distal RDN compared to conventional main renal artery intervention (ClinicalTrials.gov NCT02667912) for the treatment of resistant HTN included 26 patients. All patients were divided into two groups: group 1 (n=16) — distal RDN, group 2 (n=10) — conventional RDN. In addition to 24-hour blood pressure (BP) monitoring, initially and 12 months after the intervention, contrast- enhanced cardiac magnetic resonance imaging was performed to determine the left ventricular mass and non-coronary myocardial damage area. All patients signed informed consent. Twenty-four patients completed the present study.Results. After 12 months, the mean 24-hour BP significantly decreased after both distal RDN (from 167,2±28,5/93,2±19,3 to 147,0±13,7/81,5±9,3 mm Hg (p<0,05)) and conventional RDN (from 157,5±22,5/90,6±23,9 to 139,9±17,7/80,0±16,7 (p<0,05)). Also in both cases, a trend to LV mass decrease was revealed: from 252,6±85,2 to 221,0±60,3 gm (p=0,096) after the distal RDN; from 214,3±54,1 to 186,4±48,1 gm (p=0,071) after the conventional RDN. In contrast, the myocardial damage area decreased only after distal RDN (from 2,33±1,33 to 1,35±0,67 cm3 (p=0,02)) and did not change after conventional RDN.Conclusion. In comparison with the conventional main renal artery intervention, distal RDN in patients with resistant HTN has an additional cardioprotective effect — a decrease in LV myocardial damage area.
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McArdle, Zoe, Roberto B. Pontes, Song T. Yao, Yugeesh R. Lankadeva, Reetu R. Singh, Sally G. Hood, Markus P. Schlaich, Clive N. May, and Lindsea C. Booth. "Blunted diuretic and natriuretic responses to acute sodium loading early after catheter-based renal denervation in normotensive sheep." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 317, no. 2 (August 1, 2019): R319—R327. http://dx.doi.org/10.1152/ajpregu.00228.2018.
Повний текст джерелаАнотація:
Catheter-based renal denervation (RDN) was introduced as a treatment for resistant hypertension. There remain critical questions regarding the physiological mechanisms underlying the hypotensive effects of catheter-based RDN. Previous studies indicate that surgical denervation reduces renin and the natriuretic response to saline loading; however, the effects on these variables of catheter-based RDN, which does not yield complete denervation, are largely unknown. The aim of this study was to investigate the effects of catheter-based RDN on glomerular-associated renin and regulation of fluid and sodium homeostasis in response to physiological challenges. First, immunohistochemical staining for renin was performed in normotensive sheep ( n = 6) and sheep at 1 wk ( n = 6), 5.5 mo ( n = 5), and 11 mo ( n = 5) after unilateral RDN using the same catheter used in patients (Symplicity). Following catheter-based RDN (1 wk), renin-positive glomeruli were significantly reduced compared with sham animals ( P < 0.005). This was sustained until 5.5 mo postdenervation. To determine whether the reduction in renin after 1 wk had physiological effects, in a separate cohort, Merino ewes were administered high and low saline loads before and 1 wk after bilateral RDN ( n = 9) or sham procedure ( n = 8). After RDN (1 wk), the diuretic response to a low saline load was significantly reduced ( P < 0.05), and both the diuretic and natriuretic responses to a high saline load were significantly attenuated ( P < 0.05). In conclusion, these findings indicate that catheter-based RDN acutely alters the ability of the kidney to regulate fluid and electrolyte balance. Further studies are required to determine the long-term effects of catheter-based RDN on renal sodium and water homeostasis.
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Wang, Weiyi, Liying Xu, Lingming Zhou, Shanhong Wan, and Libin Jiang. "A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Rhizoma Dioscoreae Nipponicae in the Treatment of Asthma." Evidence-Based Complementary and Alternative Medicine 2022 (March 30, 2022): 1–17. http://dx.doi.org/10.1155/2022/4749613.
Повний текст джерелаАнотація:
Background. In this study, network pharmacological methods were used to analyze the targets of Rhizoma Dioscoreae Nipponicae (RDN) and investigate the potential underlying mechanism of RDN in the treatment of asthma. Methods. Asthma-related targets were obtained from the GeneCards and DisGeNET databases. The bioactive components of RDN were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database, and the targets of these compounds were predicted using the BATMAN-TCM database. The network of RDN component targets was constructed using Cytoscape. A protein-protein interaction (PPI) network was constructed in Cytoscape to determine the potential targets of RDN for the treatment of asthma. The hub genes of RDN in the treatment of asthma were screened using network topological parameters. Gene ontology (GO) and the KEGG pathways were analyzed. Molecular docking and in vivo experiments were performed to validate the network pharmacology results. Results. A total of four bioactive components and 55 targets were identified. The results of the enrichment analysis suggested that the treatment of asthma with RDN involved signaling pathways, such as those related to systemic lupus erythematosus, alcoholism, viral carcinogenesis, the cell cycle, prostate cancer, transcriptional misregulation in cancer, hepatitis B, thyroid hormone signaling, and PI3K-AKT signaling, as well as other signaling pathways. Molecular docking showed that the active components of RDN could stably bind to the predicted target. In vivo experiments showed that RDN could regulate the expression of target genes and inhibit the activation of the PI3K-AKT signaling pathway. Conclusion. To a certain extent, this study reveals the potential bioactive components and molecular mechanisms of RDN in the treatment of asthma and provides new insights for the development of new drugs for asthma.
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Versaci, Francesco, Sebastiano Sciarretta, Massimiliano Scappaticci, Riccardo Di Pietro, Simone Calcagno, Armando Del Prete, Carlo Gaspardone, and Giuseppe Biondi Zoccai. "Renal arteries denervation: from the treatment of resistant hypertension to the treatment of atrial fibrillation." European Heart Journal Supplements 23, Supplement_E (October 1, 2021): E177—E183. http://dx.doi.org/10.1093/eurheartj/suab117.
Повний текст джерелаАнотація:
Abstract Renal denervation (RDN) is a therapeutic strategy for patients with uncontrolled arterial hypertension characterized by considerable fluctuations during its progression. After initial strong enthusiasm, the procedure came to an abrupt halt following the publication of the Symplicity HTN-3 study results. The results of recently published studies highlight the reduction in blood pressure values after RDN and justify the inclusion in the Guidelines of new recommendations for the use of RDN in clinical practice, in selected patients. Additionally, RDN findings are summarized in view of other potential indications such as atrial fibrillation. Six prospective, randomized studies are presented that evaluated RDN as an adjunct therapy to pulmonary vein isolation for the treatment of atrial fibrillation. In five studies, patients had uncontrolled hypertension despite therapy with three antihypertensive drugs. The analysis of these studies showed that RDN reduced the recurrence of atrial fibrillation (AF) by 57% compared to patients with pulmonary vein isolation (PVI) only. Modulation of the autonomic nervous system by RDN has been shown not only to reduce blood pressure but also to have an antiarrhythmic effect in symptomatic AF patients when the strategy is combined with PVI, thus opening up new therapeutic scenarios.
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Alsheikh, Ammar J., Hayley Lund, John Henry Dasinger, Justine M. Abais-Battad, Daniel J. Fehrenbach, and David L. Mattson. "Renal nerves and leukocyte infiltration in the kidney during salt-sensitive hypertension." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 317, no. 1 (July 1, 2019): R182—R189. http://dx.doi.org/10.1152/ajpregu.00070.2019.
Повний текст джерелаАнотація:
Based on previous studies suggesting a role of renal nerves in renal inflammation, the present studies were performed to test the hypothesis that renal nerves mediate renal damage in Dahl salt-sensitive (SS) hypertension by increasing renal leukocyte infiltration. Experiments were performed in Dahl SS rats with bilateral renal denervation (RDN) and bilateral sham operation ( n = 10 or 11 per group) and with unilateral RDN and contralateral sham operation ( n = 10). After denervation, rats were switched from a low-salt 0.4% NaCl (LS) diet to a high-salt 4% NaCl (HS) diet and maintained on HS diet for 21 days. Bilateral RDN reduced the magnitude of hypertension assessed by radiotelemetry in Dahl SS rats compared with sham-operated rats (mean arterial pressure 140.9 ±4.8 mmHg and 159.7 ± 3.5 mmHg, respectively) and reduced proteinuria at day 21 of HS diet. However, assessment of renal leukocyte infiltration demonstrated no significant effect of bilateral RDN on the number of infiltrating leukocytes (RDN 3.6 ± 0.5 × 106 vs. sham operated 4.3 ± 0.3 × 106 CD45+ cells) or any of the subsets examined by flow cytometry. The unilateral RDN experiment showed no effect of RDN on the renal infiltration of leukocytes (RDN 6.5 ± 0.9 × 106 vs. sham operated 6.1 ± 1.1 × 106 CD45+ cells/kidney) or renal damage in RDN vs. sham-operated kidney after 21 days of HS diet. This work investigated the relationship between renal nerves and renal inflammation during Dahl SS hypertension. Contrary to our hypothesis, the results of this work suggest that immune cell infiltration in the kidney of Dahl SS rats is not mediated by the renal nerves.
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Gupta, Pratima, and Monseng N. Sangma. "Effect of inorganic fertilizer dose and vermicompost on growth and yield of Guava (Psidium guajava L.) cv. Lalit." International Journal of Agricultural Invention 2, no. 02 (November 19, 2017): 174–80. http://dx.doi.org/10.46492/ijai/2017.2.2.12.
Повний текст джерелаАнотація:
The experiment was conducted on two years old guava at Research Field, Department of Horticulture, SHUATS, Allahabad, during the year 2016-2017. It was laid out in Randomized Block Design (R.B.D) with 4 replications and 11 treatments. The treatments included different levels of inorganic fertilizer and vermicompost. The maximum increase in plant height (155.71 cm), number of branches (25.23), canopy spread E-W direction (101.88 cm) and N-S direction (104.88 cm), was obtained with the application of T10 [50% RDN through chemical fertilizer +50% RDN through vermicompost (100:50:50 g NPK+1kg vermicompost)]. Maximum number of flowers/plant (18.25), fruit set (48.42%), fruit length (7.57 cm), fruit diameter (7.78 cm), volume of fruit (118cm3) and specific gravity (1.14 g/ml), were recorded with the application of T10 (50% RDN through chemical fertilizer +50% RDN through vermicompost), which was superior as compared to other treatments taken under present study. The maximum average fruit weight (128g) and number of fruits per plant (8.53) as well as significant highest yield per plant (959.14g) were obtained with the application of 50% RDN through chemical fertilizer+50% RDN through vermicompost (T10). The maximum total soluble solids (12.040Brix), ascorbic acid (180.89mg/100 g pulp) and minimum titratable acidity (0.51%) were recorded with the soil placement of 50% RDN through chemical fertilizer +50% RDN through vermicompost (T10), which was superior and economically viable as compare to other treatments with a maximum cost benefit (C:B) ratio of (1: 1.04).
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Prado, Armando Pérez de, Claudia Pérez-Martínez, Marta Regueiro-Purriños, Carlos Cuellas-Ramón, María López-Benito, José Manuel Gonzalo-Orden, Rodrigo Estévez-Loureiro, et al. "Development and Evaluation of a Disease Large Animal Model for Preclinical Assessment of Renal Denervation Therapies." Animals 10, no. 9 (August 19, 2020): 1446. http://dx.doi.org/10.3390/ani10091446.
Повний текст джерелаАнотація:
New-generation catheters-based renal denervation (RDN) is under investigation for the treatment of uncontrolled hypertension (HTN). We assessed the feasibility of a large animal model of HTN to accommodate the human RDN devices. Ten minipigs were instrumented to measure blood pressure (BP) in an awake-state. HTN was induced with subcutaneous 11-deoxycorticosterone (DOCA, 100 mg/kg) implants. Five months after, the surviving animals underwent RDN with the Symplicity® system. Norepinephrine (NE) renal gradients were determined before and 1 month after RDN. Renal arteries were processed for histological (hematoxylin-eosin, Movat pentachrome) and immunohistochemical (S100, tyrosine-hydroxylase) analyses. BP significantly rose after DOCA implants. Six animals died prematurely, mainly from infectious causes. The surviving animals showed stable BP levels after 5 months. One month after RDN, nerve damage was showed in three animals, with impedance drop >10%, NE gradient drop and reduction in BP. The fourth animal showed no nerve damage, impedance drop <10%, NE gradient increase and no change in BP. In conclusion, the minipig model of DOCA-induced HTN is feasible, showing durable effects. High mortality should be addressed in next iterations of this model. RDN may partially offset the DOCA-induced HTN. Impedance drop and NE renal gradient could be markers of RDN success.
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Kario, Kazuomi, Byeong-Keuk Kim, Jiro Aoki, Anthony Yiu-tung Wong, Ying-Hsiang Lee, Nattawut Wongpraparut, Quang Ngoc Nguyen, et al. "Renal Denervation in Asia." Hypertension 75, no. 3 (March 2020): 590–602. http://dx.doi.org/10.1161/hypertensionaha.119.13671.
Повний текст джерелаАнотація:
The Asia Renal Denervation Consortium consensus conference of Asian physicians actively performing renal denervation (RDN) was recently convened to share up-to-date information and regional perspectives, with the goal of consensus on RDN in Asia. First- and second-generation trials of RDN have demonstrated the efficacy and safety of this treatment modality for lowering blood pressure in patients with resistant hypertension. Considering the ethnic differences of the hypertension profile and demographics of cardiovascular disease demonstrated in the SYMPLICITY HTN (Renal Denervation in Patients With Uncontrolled Hypertension)-Japan study and Global SYMPLICITY registry data from Korea and Taiwan, RDN might be an effective hypertension management strategy in Asia. Patient preference for device-based therapy should be considered as part of a shared patient-physician decision process. A practical population for RDN treatment could consist of Asian patients with uncontrolled essential hypertension, including resistant hypertension. Opportunities to refine the procedure, expand the therapy to other sympathetically mediated diseases, and explore the specific effects on nocturnal and morning hypertension offer a promising future for RDN. Based on available evidence, RDN should not be considered a therapy of last resort but as an initial therapy option that may be applied alone or as a complementary therapy to antihypertensive medication.
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Yamada, Shinya, Li-Wei Lo, Yu-Hui Chou, Wei-Lun Lin, Shih-Lin Chang, Yenn-Jiang Lin, Shin-Huei Liu, Wen-Han Cheng, Tsung-Ying Tsai, and Shih-Ann Chen. "Renal denervation ameliorates the risk of ventricular fibrillation in overweight and heart failure." EP Europace 22, no. 4 (January 29, 2020): 657–66. http://dx.doi.org/10.1093/europace/euz335.
Повний текст джерелаАнотація:
Abstract Aims Both obesity and heart failure (HF) are associated with sudden cardiac death. The current study aimed to investigate the effects of overweight and HF on the substrate for ventricular fibrillation (VF), and whether renal denervation (RDN) can protect the heart from sympathetic activation and cardiac remodelling in HF rabbits fed with high-fat diet (HFD). Methods and results Twenty-four rabbits randomized into control group fed with regular diet (Control), HFD, HFD-HF, and HFD-HF-RDN groups. Rapid ventricular pacing of 400 b.p.m. for 4 weeks was applied in HFD-HF and HFD-HF-RDN. Surgical and chemical RDNs were approached through bilateral retroperitoneal flank incisions in HFD-HF-RDN. All rabbits received electrophysiological study and a VF inducibility test. The ventricular myocardium was harvested for trichrome stain. After 3 months, mean body weight was heavier in HFD, compared with control (3.5 ± 0.1 kg vs. 2.6 ± 0.1 kg, P < 0.01). No differences in body weight among the three groups fed with HFD were observed. The ventricular refractory periods were longer in HFD-HF and HFD-HF-RDN than in control. An extension of ventricular fibrosis was observed in HFD and HFD-HF compared with control, and the degree of ventricular fibrosis was suppressed in HFD-HF-RDN compared with HFD-HF. The level of tyrosine hydroxylase staining was reduced in HFD-HF-RDN compared with HFD and HFD-HF. Importantly, VF inducibility was lower in HFD-RDN-HF (10 ± 4%), when compared with those in HFD-HF (58 ± 10%, P < 0.01) and HFD (42 ± 5%, P < 0.05), respectively. Conclusion Our results suggest that overweight and HF increase sympathetic activity, structural remodelling, and VF inducibility, but RDN prevents them.
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Berukstis, Andrius, Rokas Navickas, Gintarė Neverauskaite-Piliponiene, Ligita Ryliskyte, Jonas Misiura, Donatas Vajauskas, Nerijus Misonis, and Aleksandras Laucevicius. "Arterial Destiffening Starts Early after Renal Artery Denervation." International Journal of Hypertension 2019 (March 3, 2019): 1–7. http://dx.doi.org/10.1155/2019/3845690.
Повний текст джерелаАнотація:
Introduction. Renal artery denervation (RDN) is a new widely discussed method in treatment of hypertension. Most of the RDN studies assessed BP and arterial changes 3 and 6 months after the procedure, but there is a lack of trials that investigated early changes after RDN. Aim. To investigate aortic stiffness 24-48 hours after the procedure and thus to examine whether RDN might have an early additive value for a cardiovascular risk decline beyond the lowering of blood pressure. Methods. RDN was performed for 73 patients with resistant hypertension. Arterial stiffness and central haemodynamics were measured before the procedure, the next day after the procedure, and subsequently after 1, 3, 6, and 12 months. Results. Within 48 hours, RDN significantly reduced aortic pulse wave velocity (AoPWV) from 11.3±2.7 to 10.3±2.6 m/s (p=0.001); reduction was sustained at months 1, 3, 6, and 12. Early changes in the AoPWV value did not correlate with changes in office systolic or diastolic BP (p=0.45; p=0.33). Furthermore, the higher the initial AoPWV value, the greater the reduction of AoPWV observed after 6 months: Q1 8.4±1, Δ0.05±1.6 / Q2 10.1±0.4, Δ1.1±1.4 / Q3 12.2±0.8, Δ1.8±1.7 / Q4 15.3±1.7, Δ2.8±2.1 (p=0.002). Conclusions. Early and sustained effects on AoPWV observed in our study suggest that RDN may have additional effects on reducing arterial stiffness and cardiovascular risk.
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Sitkova, E. S., V. F. Mordovin, T. M. Ripp, S. E. Pekarskii, T. R. Ryabova, V. A. Lichikaki, A. Yu Falkovskaya, O. V. Mochula, V. Yu Usov, and A. E. Baev. "Positive effects of renal denervation on left ventricular hypertrophy and subendocardial damage." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 25, no. 1 (March 30, 2019): 46–59. http://dx.doi.org/10.18705/1607-419x-2019-25-1-46-59.
Повний текст джерелаАнотація:
Background. The high prevalence of cardiac damage in resistant hypertensive patients signifcantly increases the risk of cardiovascular complications. Despite the antihypertensive effcacy of renal denervation (RDN), the cardioprotective effect has not been suffciently studied.Objective. To study the changes in left ventricular mass (LVM) and volume of myocardial damage after the RDN and to detect a possible connection of the studied parameters with blood pressure (BP) reduction after RDN.Design and methods. RDN was applied to 84 patients with resistant hypertension. Initially, at 6 and 12 months after treatment, patients underwent the measurements of the “offce” BP, 24-h BP, echocardiography and cardiac contrast-enhanced magnet-resistance tomography.Results. At baseline, “offce” BP averaged 175,3 ± 22,1 / 100,4 ± 16,1 mmHg and the prevalence of left ventricular hypertrophy (LVH) was 84,5 %. “Offce” BP reduced signifcantly at 6 month by –27,5 (–74,0; 12,0) / –14,2 (–39,4; 10,3) mmHg (p < 0,001), at 12 month by –31,6 (–78,7; 8,3) / –15,5 (–43,3; 10,2) mmHg (p < 0,001). 24-h BP reduced signifcantly at 6 month by –13,0 (–45,2; 17,6) / –6 (–27,8; 8,9) mmHg (p < 0,001), at 12 month by –14,3 (–52; 25) / –7,3 (–26; 15,0) mmHg (p < 0,001). At 12 month after RDN LVM decreased by 6,9% (p = 0,015), LV mass index by 5,5 % (p = 0,020). According to MR study, subendocardial damage was detected in 100% of patients in the absence of coronary atherosclerosis. A volume of subendocardial damage signifcantly reduced by 29 % at 6 month (p = 0,031) and by 41,4% at 12 months after RDN (p = 0.008). LVM reduced signifcantly by 18,3 % (р = 0,008). LVM also reduced signifcantly in non-responder’s group at 6 month after RDN (р = 0,046). The regression of subendocardial damage correlated with the change in systolic BP at 12 months after RDN (р = 0,034). There was no signifcant correlation between LVH regression and baseline BP and its change after RDN.Conclusions. One year after RDN, LVH decreased independently from the BP change. Subendocardial damage was detected in 100% patients, regressed at 6 months after RDN and correlated with the regression of systolic BP at 12 month after the RDN.
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Zheng, Hong, Xuefei Liu, Neeru M. Sharma та Kaushik P. Patel. "Renal denervation improves cardiac function in rats with chronic heart failure: Effects on expression of β-adrenoceptors". American Journal of Physiology-Heart and Circulatory Physiology 311, № 2 (1 серпня 2016): H337—H346. http://dx.doi.org/10.1152/ajpheart.00999.2015.
Повний текст джерелаАнотація:
Chronic activation of the sympathetic drive contributes to cardiac remodeling and dysfunction during chronic heart failure (HF). The present study was undertaken to assess whether renal denervation (RDN) would abrogate the sympathoexcitation in HF and ameliorate the adrenergic dysfunction and cardiac damage. Ligation of the left coronary artery was used to induce HF in Sprague-Dawley rats. Four weeks after surgery, RDN was performed, 1 wk before the final measurements. At the end of the protocol, cardiac function was assessed by measuring ventricular hemodynamics. Rats with HF had an average infarct area >30% of the left ventricle and left ventricular end-diastolic pressure (LVEDP) >20 mmHg. β1- and β2-adrenoceptor proteins in the left ventricle were reduced by 37 and 49%, respectively, in the rats with HF. RDN lowered elevated levels of urinary excretion of norepinephrine and brain natriuretic peptide levels in the hearts of rats with HF. RDN also decreased LVEDP to 10 mmHg and improved basal dP/d t to within the normal range in rats with HF. RDN blunted loss of β1-adrenoceptor (by 47%) and β2-adrenoceptor (by 100%) protein expression and improved isoproterenol (0.5 μg/kg)-induced increase in +dP/d t (by 71%) and −dP/d t (by 62%) in rats with HF. RDN also attenuated the increase in collagen 1 expression in the left ventricles of rats with HF. These findings demonstrate that RDN initiated in chronic HF condition improves cardiac function mediated by adrenergic agonist and blunts β-adrenoceptor expression loss, providing mechanistic insights for RDN-induced improvements in cardiac function in the HF condition.
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Tu, Shan, Zhi-Jie Shen, Xiao-Yan Wang, Li-Xiong Zeng, and Zhi-Hui Zhang. "Catheter-Based Radiofrequency Renal Sympathetic Denervation Decreases Left Ventricular Hypertrophy in Hypertensive Dogs." Mediators of Inflammation 2021 (April 24, 2021): 1–14. http://dx.doi.org/10.1155/2021/9938486.
Повний текст джерелаАнотація:
This study explored the effects of renal sympathetic denervation (RDN) on hyperlipidity-induced cardiac hypertrophy in beagle dogs. Sixty beagles were randomly assigned to the control group, RDN group, or sham-operated group. The control group was fed with a basal diet, while the other two groups were given a high-fat diet to induce model hypertension. The RDN group underwent an RDN procedure, and the sham-operated group underwent only renal arteriography. At 1, 3, and 6 months after the RDN procedure, the diastolic blood pressure (DBP) and systolic blood pressure (SBP) levels were markedly decreased in the RDN group relative to the sham group ( P < 0.05 ). After 6 months, serum norepinephrine (NE) and angiotensin II (AngII), as well as left ventricular levels, in the RDN group were statistically lower than those in the sham group ( P < 0.05 ). Also, the left ventricular mass (LVM) and left ventricular mass index (LVMI) were significantly decreased, while the E/A peak ratio was drastically elevated ( P < 0.05 ). Pathological examination showed that the degree of left ventricular hypertrophy and fibrosis in the RDN group was statistically decreased relative to those of the sham group and that the collagen volume fraction (CVF) and perivascular circumferential collagen area (PVCA) were also significantly reduced ( P < 0.05 ). Renal sympathetic denervation not only effectively reduced blood pressure levels in hypertensive dogs but also reduced left ventricular hypertrophy and myocardial fibrosis and improved left ventricular diastolic function. The underlying mechanisms may involve a reduction of NE and AngII levels in the circulation and myocardial tissues, which would lead to the delayed occurrence of left ventricular remodeling.
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Zaldivia, Maria T. K., Dagmara Hering, Petra Marusic, Yusuke Sata, Rebecca Lee, Murray D. Esler, Nay M. Htun, et al. "Successful renal denervation decreases the platelet activation status in hypertensive patients." Cardiovascular Research 116, no. 1 (February 4, 2019): 202–10. http://dx.doi.org/10.1093/cvr/cvz033.
Повний текст джерелаАнотація:
Abstract Aims To determine whether renal denervation (RDN) in hypertensive patients affects the platelet activation status. Methods and results We investigated the effect of RDN on the platelet activation status in 41 hypertensive patients undergoing RDN. Ambulatory blood pressure (BP), plasma sympathetic neurotransmitter Neuropeptide Y, and platelet activation markers were measured at baseline, at 3 months, and 6 months after RDN. RDN significantly decreased BP at 3 months (150.6 ± 11.3/80.9 ± 11.4 mmHg to 144.7 ± 12.0/77.1 ± 11.1 mmHg; P < 0.01) and at 6 months (144.3 ± 13.8/78.3 ± 11.1 mmHg; P < 0.01). Plasma levels of the sympathetic neurotransmitter Neuropeptide Y, an indicator of sympathetic nerve activity, were significantly decreased at 3 months (0.29 ± 0.11 ng/mL to 0.23 ± 0.11 ng/mL; P < 0.0001) and at 6 months (0.22 ± 0.12 ng/mL; P < 0.001) after RDN. This was associated with a reduction in platelet membrane P-selectin expression (3 months, P < 0.05; 6 months, P < 0.05), soluble P-selectin (6 months, P < 0.05), circulating numbers of platelet-derived extracellular vesicles (EVs) (3 months, P < 0.001; 6 months, P < 0.01), and phosphatidylserine expressing EVs (3 months, P < 0.001; 6 months, P < 0.0001), indicative of a reduction in platelet activation status and procoagulant activity. Only patients who responded to RDN with a BP reduction showed inhibition of P-selectin expression at 3 months (P < 0.05) and 6 months (P < 0.05) as well as reduction of glycoprotein IIb/IIIa activation at 3 months (P < 0.05). Notably, 13 patients who took aspirin did not show significant reduction in platelet P-selectin expression following RDN. Conclusion Our results imply a connection between the sympathetic nervous system and the platelet activation status and provide a potential mechanistic explanation by which RDN can have favourable effects towards reducing cardiovascular complications.
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Vakhrushev, Aleksandr D., Heber Ivan Сondori Leonardo, Natalia S. Goncharova, Lev E. Korobchenko, Lubov B. Mitrofanova, Elizaveta M. Andreeva, Elena G. Koshevaya, Dmitry S. Lebedev, and Evgeny N. Mikhaylov. "Pulmonary and Systemic Hemodynamics following Multielectrode Radiofrequency Catheter Renal Denervation in Acutely Induced Pulmonary Arterial Hypertension in Swine." BioMed Research International 2021 (November 2, 2021): 1–10. http://dx.doi.org/10.1155/2021/4248111.
Повний текст джерелаАнотація:
Objective. We aimed to assess the effects of renal denervation (RDN) on systemic and pulmonary hemodynamics in a swine model of thromboxane A2- (TXA2-) induced pulmonary arterial hypertension (PAH). Methods. The study protocol comprised two PAH inductions with a target mean pulmonary artery pressure (PAP) of 40 mmHg at baseline and following either the RDN or sham procedure. Ten Landrace pigs underwent the first PAH induction; then, nine animals were randomly allocated in 1 : 1 ratio to RDN or sham procedure; the second PAH induction was performed in eight animals (one animal died of pulmonary embolism during the first PAH induction, and one animal died after RDN). In the RDN group, ablation was performed in all available renal arteries, and balloon inflation within artery branches was performed in controls. An autopsy study of the renal arteries was performed. Results. At baseline, the target mean PAP was achieved in all animals with 25.0 [20.1; 25.2] mcg of TXA2. The second PAH induction required the same mean TXA2 dose and infusion time. There was no statistically significant difference in the mean PAP at second PAH induction between the groups ( 39.0 ± 5.3 vs. 39.75 ± 0.5 mmHg, P > 0.05 ). In the RDN group, the second PAH induction resulted in a numerical but insignificant trend toward a decrease in the mean systemic blood pressure and systemic vascular resistance, when compared with the baseline induction ( 74 ± 18.7 vs. 90.25 ± 28.1 mmHg and 1995.3 ± 494.3 vs. 2433.7 ± 1176.7 d y n ∗ sec ∗ c m − 5 , P > 0.05 , respectively). No difference in hemodynamic parameters was noted in the sham group between the first and second PAH induction. Autopsy demonstrated artery damage in both groups, but RDN resulted in more severe lesions. Conclusions. According to our results, RDN does not result in significant acute pulmonary or systemic hemodynamic changes in the TXA2-induced PAH model. The potential chronic effects of RDN on PAH require further research.
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Feyz, Lida, Maureen Henneman, Fred Verzijlbergen, Isabella Kardys, Nicolas M. Van Mieghem, and Joost Daemen. "Renal sympathetic denervation in patients with vasospastic angina." Journal of Nuclear Cardiology 27, no. 6 (February 13, 2019): 2202–9. http://dx.doi.org/10.1007/s12350-019-01598-y.
Повний текст джерелаАнотація:
Abstract Background Sympathetic overactivity has been linked to vasospastic angina (VSA), although the exact pathophysiology of VSA is poorly understood. The purpose of this study is to assess if renal sympathetic denervation (RDN) reduces cardiac sympathetic nerve activity with a subsequent beneficial effect on angina relief in patients with refractory VSA. Methods and results Cardiac sympathetic nerve activity was assessed prior to procedure and at 6 months post-procedure using iodine-123 labeled meta-iodobenzylguanidine (123I-MIBG) imaging. The Seattle Angina questionnaire (SAQ) was used to assess the degree to which the disease impacts quality of life. No significant change was observed in early HMR (pre-RDN: 2.74 [2.10 to 3.21] vs 6 months post-RDN: 2.57 [2.20 to 3.00]; P = 0.76), and late HMR (pre-RDN: 2.56 [2.18 to 3.20] vs 6 months post-RDN: 2.36 [2.13 to 3.22]; P = 0.22). Additionally, no change was seen in WR (P = 0.22). SAQ results revealed significant improvements in perceived physical limitation, angina frequency, and quality of life at 6 months (P < 0.05 for all). Conclusion RDN resulted in improvements in angina class and quality of life at 6 months in patients with refractory VSA. RDN, however, did not result in significant changes in cardiac sympathetic nerve activity as measured using 123I-MIBG. The latter observation should be considered with caution given the small sample size of this study. Larger studies are needed to assess this further.
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Zheng, Hong, Xuefei Liu, Kenichi Katsurada, and Kaushik P. Patel. "Renal denervation improves sodium excretion in rats with chronic heart failure: effects on expression of renal ENaC and AQP2." American Journal of Physiology-Heart and Circulatory Physiology 317, no. 5 (November 1, 2019): H958—H968. http://dx.doi.org/10.1152/ajpheart.00299.2019.
Повний текст джерелаАнотація:
Previously we have shown that increased expression of renal epithelial sodium channels (ENaC) may contribute to the renal sodium and water retention observed during chronic heart failure (CHF). The goal of this study was to examine whether renal denervation (RDN) changed the expressions of renal sodium transporters ENaC, sodium-hydrogen exchanger-3 proteins (NHE3), and water channel aquaporin 2 (AQP2) in rats with CHF. CHF was produced by left coronary artery ligation in rats. Four weeks after ligation surgery, surgical bilateral RDN was performed. The expression of ENaC, NHE3, and AQP2 in both renal cortex and medulla were measured. As a functional test for ENaC activation, diuretic and natriuretic responses to ENaC inhibitor benzamil were monitored in four groups of rats (Sham, Sham+RDN, CHF, CHF+RDN). Western blot analysis indicated that RDN (1 wk later) significantly reduced protein levels of α-ENaC, β-ENaC, γ-ENaC, and AQP2 in the renal cortex of CHF rats. RDN had no significant effects on the protein expression of kidney NHE3 in both Sham and CHF rats. Immunofluorescence studies of kidney sections confirmed the reduced signaling of ENaC and AQP2 in the CHF+RDN rats compared with the CHF rats. There were increases in diuretic and natriuretic responses to ENaC inhibitor benzamil in rats with CHF. RDN reduced the diuretic and natriuretic responses to benzamil in CHF rats. These findings suggest a critical role for renal nerves in the enhanced expression of ENaC and AQP2 and subsequent pathophysiology of renal sodium and water retention associated with CHF. NEW & NOTEWORTHY This is the first study to show in a comprehensive way that renal denervation initiated after a period of chronic heart failure reduces the expression of epithelial sodium channels and aquaporin 2 leading to reduced epithelial sodium channel function and sodium retention.
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WEI, XIAOYONG, and XI YAO. "REVERSIBLE DIELECTRIC NONLINEARITY AND MECHANISM OF ELECTRICAL TUNABILITY FOR FERROELECTRIC CERAMICS." International Journal of Modern Physics B 20, no. 21 (August 20, 2006): 2977–98. http://dx.doi.org/10.1142/s021797920603500x.
Повний текст джерелаАнотація:
In this paper, a brief review on reversible dielectric nonlinearity (RDN) was presented and the mechanism of tunability for ferroelectric ceramics was discussed in several different scale levels, such as atomic level (intrinsic nonlinearity described by ferroelectric thermodynamic theory), nano-meter scale (polar nano-region response), submicron scale (ferroelectric domain and domain wall motion), micron scale (polycrystalline structure of ceramics and surface layer) and macroscopic scale (field induced phase transition). It suggests that RDN is a multi-scale phenomenon and is temperature and frequency-sensitive. The halving field E0 in Roberts' Equation may be a good attempt for the quantitating of RDN. The stability of RDN in paraelectric phase is also mentioned.
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Kądziela, Jacek. "Renal denervation – not an easy road to treatment of arterial hypertension and concomitant diseases." In a good rythm 3, no. 56 (October 21, 2020): 35–41. http://dx.doi.org/10.5604/01.3001.0014.4646.
Повний текст джерелаАнотація:
Percutaneous renal denervation (RDN) has been introduced in clinical trials as the possible interventional method of treatment of resistant hypertension more than one decade ago. The results of trials: SYMPLICITY HTN-1 (single-arm), HTN-2 (randomized, single-blinded) and HTN-3 (with sham procedure) are summarized in this article. The author presents the results of second-generation trials with new technologies: Spyral catheter (radiofrequency RDN) and Paradise system (ultrasound RDN). The favorable results of these studies justify the revision of the current recommendations, limiting this method only to clinical trials. Also the studies on RDN applied in atrial fibrillation and obstructive sleep apnea – diseases related to sympathetic nervous system activity – are discussed.
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Kumar, Sandeep, Surendra Kumar Sharma, Sanjay Kumar Thakral, Krishan Kumar Bhardwaj, Manoj Kumar Jhariya, Ram Swaroop Meena, Chetan Kumar Jangir, et al. "Integrated Nutrient Management Improves the Productivity and Nutrient Use Efficiency of Lens culinaris Medik." Sustainability 14, no. 3 (January 24, 2022): 1284. http://dx.doi.org/10.3390/su14031284.
Повний текст джерелаАнотація:
Enhancing nutrient use efficiencies (NUEs) is an important factor in achieving the long-term sustainability of a production system. Our two-year experiment was aimed at accessing the NUEs of the integration of macro- and micronutrient fertilization responses of three lentil (Lens culinaris) cultivars. Three cultivars were planted in the main plots, and ten nutrient combinations were used in the sub-plots: N1, control; N2, 100% recommended dose of fertilizers (RDF) (20:40—N:P2O5); N3, vermicompost (VC) at 2 t ha−1; N4, 50% recommended dose of nitrogen (RDN) + 100% recommended dose of phosphorus (RDP) + VC at 1 t ha−1; N5, RDF + 0.5% ZnSO4; N6, RDF + 0.5% FeSO4; N7, RDF + 0.5% ZnSO4 + 0.5% FeSO4; N8, 50% RDN + 100% RDP + VC at 1 t ha−1 + 0.5% ZnSO4; N9, 50% RDN + 100% RDP + VC at 1 t ha−1 + 0.5% FeSO4; and N10, 50% RDN + 100% RDP + VC at 1 t ha−1 + 0.5% ZnSO4 + 0.5% FeSO4. The results show that the cultivar HM-1 (1.59–1.61 Mg ha−1) recorded a significantly higher seed yield than cultivars Sapna (1.31–1.33 Mg ha−1) and Garima (both 1.30 Mg ha−1), while the cultivar Sapna had significantly more stover yield (1.86–1.90 Mg ha−1) than cultivar HM-1 (1.68–1.73 Mg ha−1). Cultivar HM-1 was more efficient in terms of partial factor productivity for N (77.5–78.5 kg kg−1), P (48.2–48.7 kg kg−1), K (143.6–145.5 kg kg−1), Zn (1336–1352 kg kg−1), and Fe (417–421 kg kg−1) than Sapna and Garima. Application of 50% N + 100% P + VC at 1.0 t ha−1 + 0.5% ZnSO4 + 0.5% FeSO4 resulted in higher seed yield (1.63–1.65 Mg ha−1) and agronomic efficiency for N (26.3–28.8 kg kg−1), P (12.42–13.63 kg kg−1), and K (52.3–57.4 kg kg−1) over other tested practices in both years. Hence, it could be concluded that considering the integrated nutrient management paradigm including 10 kg N ha−1 coupled with 40 kg P2O5 ha−1 through synthetic fertilizers, vermicomposting 1.0 t ha−1 as an organic source and foliar spray of 0.5% each of ZnSO4 and FeSO4 (N10) produced a 56.8% higher seed yield than the control, in addition to improving nutrient dynamics and NUEs for N, P, K, Zn, and Fe. Therefore, integrated fertilization coupled with cultivar selection could help to achieve the long-term food and nutritional sustainability targeted by the Sustainable Development Goals (SDGs).
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Ghasemi, Soraya, Ali Reza Kochaki, Mehdi Nassiri Mahalati, and Rajab Choukan. "Vertical Profile of Leaf Nitrogen Distribution at Different Densities of Plant And Different Levels of N Fertilizer on Corn Hybrids Canopy." Modern Applied Science 10, no. 12 (July 20, 2016): 57. http://dx.doi.org/10.5539/mas.v10n12p57.
Повний текст джерелаАнотація:
In this study, the distribution of leaf nitrogen of two corn hybrids during the growing season, in response to the density and N supply were studied. There were two corn hybrids (S.C. 704 and maxima (MV 524)) under three levels of nitrogen: Recommended (300 kg N/ha); RDN plus 25% (375 kg N/ha); RDN plus 50% (450 kg N/ha) and were three levels of population. Recommended (RDN) (7 plants m-2); RDN plus 10% (7.7 plants m-2); RDN plus 20% (8.4 plants m-2).Regular samplings were made from 40 days after sowing until crop maturity. Every 2 weeks, a 1 m2 sample of the canopy was cut in four successive vertical layers of equal thickness. Leaf area and N concentration (%) in each layer were measured. The vertical N gradient became more marked with ongoing vegetative development. The whole canopy photosynthetic benefit that would accrue from maintaining the N gradient is likely to be accentuated. The rate of decline in leaf N concentration in a layer was not related to either the initial concentration in the leaves within the layer.
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Versaci, Francesco, Sebastiano Sciarretta, Massimiliano Scappaticci, Simone Calcagno, Riccardo di Pietro, Francesca Sbandi, Angela Dei Giudici, Armando Del Prete, Stefano de Angelis, and Giuseppe Biondi-Zoccai. "Renal arteries denervation with second generation systems: a remedy for resistant hypertension?" European Heart Journal Supplements 22, Supplement_L (November 1, 2020): L160—L165. http://dx.doi.org/10.1093/eurheartj/suaa158.
Повний текст джерелаАнотація:
Abstract Initial studies on renal denervation (RDN) for the treatment of non-controlled arterial hypertension (HTN) through radiofrequency ablation of renal arteries demonstrated that RDN is an effective therapeutic strategy to reduce arterial blood pressure (BP). Nonetheless, the first randomized study, SYMPLICITY-HTN-3, failed to demonstrate a clear benefit for RND over the control group. Technologic evolution, with the introduction of new second generation multi-electrode devices, allowed deep energy delivery along the full circumference of the vessel. Two recent randomized studies involving patients assuming (SPYRAL HTN-ON MED) or not (SPYRAL HTN-OFF MED) antihypertensive pharmacologic treatment, demonstrated the efficacy and safety of RDN using second generation systems for radiofrequency ablation. Another recent randomized study demonstrated that RDN with ultrasounds (RADIANCE-HTN SOLO) of the main renal arteries led to a significant BP reduction compared to the control group. These studies have once again raised the interest of the scientific community towards attempting to define the appropriate role of RDN in the treatment of hypertension. Nonetheless, larger and longer clinical trials will be necessary to draw further conclusions.
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Mahfoud, Felix, Roland Schmieder, Justin Davies, David E. Kandzari, Joachim Weil, and Robert Whitbourn. "Catheter-based Renal Sympathetic Denervation – Long-term Symplicity™ Renal Denervation Clinical Evidence, New Data and Future Perspectives." Interventional Cardiology Review 8, no. 2 (2013): 118. http://dx.doi.org/10.15420/icr.2013.8.2.118.
Повний текст джерелаАнотація:
Hypertension is one of the most prevalent chronic diseases worldwide and the incidence of resistant hypertension is increasing. Catheter-based renal denervation (RDN) offers a new approach to reaching blood pressure goals by targeting the renal nerves. The technique has demonstrated significant and sustained reductions in blood pressure (BP) in the Symplicity HTN-1 and Symplicity HTN-2 clinical trials. The Global SYMPLICITY Registry aims to demonstrate safety and effectiveness in a ‘real-world’ patient population. Real-world RDN experience has emphasised that patient selection is crucial to successful outcomes; a multidisciplinary referral network is recommended to increase awareness of the procedure and identify patients who are likely to respond best to RDN. Further advances in catheter technology have led to the development of the multi-electrode Symplicity Spyral™ multi-electrode catheter; preliminary data from the feasibility study using the Symplicity Spyral catheter indicate clinical efficacy and procedural safety with reduced procedure times. The Symplicity Spyral catheter is not yet commercially available. The indications of RDN may also expand beyond resistant hypertension – encouraging data have been seen in patients with moderate treatment resistant hypertension. Furthermore, RDN may be beneficial in other clinical states characterised by sympathetic nervous system overactivation including heart failure and chronic kidney disease. Additional data are needed to evaluate the efficacy of RDN in these disease states.
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Markana, Anilkumar, Gargi Trivedi, and Praghnesh Bhatt. "Multi-objective optimization based optimal sizing & placement of multiple distributed generators for distribution network performance improvement." RAIRO - Operations Research 55, no. 2 (March 2021): 899–919. http://dx.doi.org/10.1051/ro/2021045.
Повний текст джерелаАнотація:
Integration of Distributed Generations (DGs) into radial distribution network (RDN) is an emerging need to explore the benefits of renewable energy sources (RES). Increasing penetration of RES based DGs in RDN without proper planning leads to several operational problems such as excessive energy losses, poor voltage quality and load balancing. Hence, in this work, multi-objective optimization (MOO) problem is formulated by carefully chosen three conflicting objectives such as power loss minimization, enhancement of load balancing index (LBI) and aggregate voltage deviation index (AVDI). Teaching-Learning-Based-Optimization (TLBO) is used to optimize MOO problem considering placement of DGs at multiple locations in RDN satisfying the constraints on bus voltage magnitude, branch flows and DG size. Comprehensive simulation studies have been carried out to obtain optimal performance for 69-nodes RDN with the increasing penetration of DGs at multiple locations. It is shown that determination of optimal sizing of DGs at multiple locations in RDN with MOO results in lesser power losses, improved voltage profiles and better load balancing as compared to placement of single DG in RDN. Performance measures such as spacing and spread indicators are used for characterizing Pareto solutions for MOO problem. Such set of non-dominated solutions obtained from Pareto front during multi-objective TLBO gives proper guidelines to the utility operator about sizing and placement of DGs based on the assigned priorities to the objectives.
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Mongay, N., N. Vidal, A. Lucas, M. Macià, G. Plans, A. Fernandez-Coello, C. Majos, L. Rodriguez-Bel, M. Alemany, and J. Bruna. "P14.93 The utility of the brain 18-FDG-PET and perfusion magnetic resonance imaging in the radionecrosis differential diagnosis." Neuro-Oncology 21, Supplement_3 (August 2019): iii89—iii90. http://dx.doi.org/10.1093/neuonc/noz126.328.
Повний текст джерелаАнотація:
Abstract BACKGROUND Radiation-induced necrosis (RDN) is a side effect observed in patients who underwent stereotactic radiosurgery (SRS) alone or combined with whole brain radiotherapy (WBRT) as treatment for their brain tumors. Nowadays, RDN diagnosis and differentiation from tumor progression using the standard imaging techniques represents a challenge, and histological diagnosis still is the gold standard.Our aim is to assess the positive and negative predictive values (PPV, NPV) of FDG-PET and perfusion magnetic resonance imaging (MRI) in RDN diagnosis. MATERIAL AND METHODS From our Pathology department database, all patients with RDN or mixed (tumor plus RDN) brain lesions diagnosis during last 5 years were reviewed. Demographic, clinical and oncologic treatment characteristics were recorded. MRI and FDG-PET images at the suspicion (clinical or radiological) of progression or RDN were registered and compared with the definite diagnosis provided by the tissue sample analysis. Sensitivity, specificity, as such as PPV and NPV for perfusion MRI sequences and FDG-PET image analysis were calculated. RESULTS 162 patients underwent SRS+/- WBRT in a 5 year period. During follow-up, 11 patients had surgery-confirmed RDN. There are 11 patients (3 women) with 12 lesions, 3 from a breast cancer, 6 from a lung tumor, 1 from a melanoma, 1 atypical meningioma and 1 glioblastoma. 9 of them were treated with both SRS and WBRT, and the 3 others with WBRT alone. The mean age was 65.36 (range: 44–77) years. The median time between the completion of radiation therapy and the suspicion of RDN was 19.7 (range: 3–34) months. With the evolution, it was observed an evident increase in the size of surronding oedema (2–6 times) by FLAIR RMI. We estimate a PPV 0.40 and NPV 0.80 for perfusion MRI, and PPV 0.25 and NPV 0.75 for FDG-PET, respectively. CONCLUSION The diagnostic performance of both techniques in our series is low and similar to published data; therefore its results must be carefully interpreted in each case. It is peremptory to implement new diagnostic tools in the standard of care with better diagnostic outcomes.
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Glybochko, P. V., A. A. Svetankova, A. V. Rodionov, A. S. Maltseva, V. A. Sulimov, and V. V. Fomin. "Renal denervation with a resistant arterial hypertension: the results of a five-year follow-up." Terapevticheskii arkhiv 90, no. 9 (September 15, 2018): 88–91. http://dx.doi.org/10.26442/terarkh201890988-91.
Повний текст джерелаАнотація:
Aim. To evaluate the 5-year results of renal denervation (RDN) in patients with resistant arterial hypertension (AH). Materials and methods. The study included 14 patients to whom, during the 2011-2013 period RDN has been completed. Before and after the intervention, office blood pressure, quality of life indicators according to the EQ-5D questionnaire, mass index bodies, indicators of kidney function were duly assessed. Results. Five years after RDN, office BP decreased from 165/110 to 139/95 mm Hg. Art. (p
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Chichkova, T. Y., S. E. Mamchur, M. P. Romanova, and E. A. Khomenko. "Renal denervation: a new life of the technology." Fundamental and Clinical Medicine 5, no. 4 (December 25, 2020): 117–25. http://dx.doi.org/10.23946/2500-0764-2020-5-4-117-125.
Повний текст джерелаАнотація:
Renal denervation (RDN) is a method of the sympathetic nervous system modulation which has been specifically developed for the treatment of resistant hypertension. Initial reports demonstrating high efficiency of RDN in such patients propelled the development of the technology, yet a specific randomised controlled trial Symplicity HTN-3 did not show its benefits. Data from the subsequent RCTs SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED have shown that RDN reduces both office and daily blood pressure, does not depend on the patient adherence, and is efficient in patients with uncontrolled hypertension even in the absence of drug therapy. This review summarises the data on the efficacy and safety of the technology, its organoprotective effects, and also discusses the benefits of the RDN in different patient groups.
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Shchelkova, G. V., A. R. Zairova, N. M. Danilov, A. N. Rogoza, and I. E. Chazova. "Effect of renal denervation on the arterial stiffness and central hemodynamics in patients with resistant hypertension." Systemic Hypertension 13, no. 4 (December 15, 2016): 7–12. http://dx.doi.org/10.26442/sg29140.
Повний текст джерелаАнотація:
Aim: to evaluate the effect of renal denervation (RDN) on the stiffness of the aorta and major arteries, central blood pressure and index augmentation in patients with resistant hypertension. Material and methods. We included 20 patients with systolic blood pressure 178 [170; 180] mm Hg and diastolic blood pressure 100 [94; 100] mm Hg on 5.1±0.7 antihypertensive drugs with diuretic, who underwent bilateral RDN. Blood pressure (BP) was studied before intervention, at 7 days and 6 months after RDN by tree methods: office BP, 24-hour ambulatory blood pressure (ABPM) and aortic BP with applanation tonometry a. radialis (SphygmoCor). All patients were divided into two groups by ABPM in 6 months after RDN: responders (decrease of mean ABPM≥5 mm Hg) and non-responders (decrease of mean ABPM
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Mahfoud, Felix, Michael Böhm, Roland Schmieder, Krzysztof Narkiewicz, Sebastian Ewen, Luis Ruilope, Markus Schlaich, Bryan Williams, Martin Fahy, and Giuseppe Mancia. "Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry." European Heart Journal 40, no. 42 (March 25, 2019): 3474–82. http://dx.doi.org/10.1093/eurheartj/ehz118.
Повний текст джерелаАнотація:
Abstract Aims Several studies and registries have demonstrated sustained reductions in blood pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in real-world patients with uncontrolled hypertension, however, remains unknown. The objective of this study was to assess the long-term safety and efficacy of RDN, including its effects on renal function. Methods and results The Global SYMPLICITY Registry is a prospective, open-label registry conducted at 196 active sites worldwide in hypertensive patients receiving RDN treatment. Among 2237 patients enrolled and treated with the SYMPLICITY Flex catheter, 1742 were eligible for follow-up at 3 years. Baseline office and 24-h ambulatory systolic BP (SBP) were 166 ± 25 and 154 ± 18 mmHg, respectively. SBP reduction after RDN was sustained over 3 years, including decreases in both office (−16.5 ± 28.6 mmHg, P < 0.001) and 24-h ambulatory SBP (−8.0 ± 20.0 mmHg; P < 0.001). Twenty-one percent of patients had a baseline estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Between baseline and 3 years, renal function declined by 7.1 mL/min/1.73 m2 in patients without chronic kidney disease (CKD; eGFR ≥60 mL/min/1.73 m2; baseline eGFR 87 ± 17 mL/min/1.73 m2) and by 3.7 mL/min/1.73 m2 in patients with CKD (eGFR <60 mL/min/1.73 m2; baseline eGFR 47 ± 11 mL/min/1.73 m2). No long-term safety concerns were observed following the RDN procedure. Conclusion Long-term data from the Global SYMPLICITY Registry representing the largest available cohort of hypertensive patients receiving RDN in a real-world clinical setting demonstrate both the safety and efficacy of the procedure with significant and sustained office and ambulatory BP reductions out to 3 years.
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Hearon, Christopher M., Erin J. Howden, Qi Fu, Jeung-Ki Yoo, Katrin A. Dias, Monique A. Roberts-Reeves, Mitchel Samels, et al. "Evidence of Reduced Efferent Renal Sympathetic Innervation After Chemical Renal Denervation in Humans." American Journal of Hypertension 34, no. 7 (March 2, 2021): 744–52. http://dx.doi.org/10.1093/ajh/hpab022.
Повний текст джерелаАнотація:
Abstract BACKGROUND Renal denervation (RDN) is effective at lowering blood pressure. However, it is unknown if ablative procedures elicit sympathetic denervation of the kidneys in humans. The aim of this investigation was to assess sympathetic innervation of the renal cortex following perivascular chemical RDN, which may be particularly effective at ablating perivascular efferent and afferent nerves. METHODS Seven hypertensive patients (4F:3M; 50–65 years) completed PET–CT sympathetic neuroimaging of the renal cortex using 11C-methylreboxetine (11C-MRB, norepinephrine transporter ligand) and 6-[18F]-fluorodopamine (18F-FDA; substrate for the cell membrane norepinephrine transporter) before and 8 weeks after chemical RDN (Peregrine System Infusion Catheter, Ablative Solutions; n = 4; 2F:2M) or control renal angiography (n = 3; 2F:1M). Patients completed physiological phenotyping including 24-hour ambulatory blood pressure, hemodynamics, muscle sympathetic nerve activity, and 24-hour urine collection. RESULTS RDN decreased 11C-MRB-derived radioactivity by ~30% (Δ 11C-MRB/chamber: −0.95 a.u. confidence interval (CI): −1.36 to −0.54, P = 0.0002), indicative of efferent RDN. In contrast, 18F-FDA-derived radioactivity increased (Δ 18F-FDA/chamber: 2.72 a.u. CI: 0.73–4.71, P = 0.009), consistent with reduced vesicular turnover. Controls showed no change in either marker. Ambulatory systolic pressure decreased in 3 of 4 patients (−9 mm Hg CI: −27 to 9, P = 0.058), and central systolic pressure decreased in all patients (−23 mm Hg CI: −51 to 5, P = 0.095). CONCLUSIONS These results are the first to show efferent sympathetic denervation of the renal cortex following RDN in humans. Further studies of mechanisms underlying variable blood pressure lowering in the setting of documented RDN may provide insights into inconsistencies in clinical trial outcomes. CLINICAL TRIALS REGISTRATION Trial Number NCT03465917.
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Varma, Golla Ravi, P. Satish, S. A. Hussain, and S. Harish Kumar Sharma. "Effect of Integrated Nutrient Management on Productivity and Economics of Indian Mustard (Brassica juncea L)." International Journal of Environment and Climate Change, August 18, 2021, 169–76. http://dx.doi.org/10.9734/ijecc/2021/v11i630433.
Повний текст джерелаАнотація:
An experiment was carried out at College farm, College of Agriculture, Rajendranagar, Hyderabad, Telangana, in sandy loam soils during rabi 2020 to study the effect of integrated nutrient management on productivity and economics of Indian mustard (Brassica juncea L.). The treatments comprised were: T1- Control (100% RDF -80:40:40 kg NPK ha-1), T2 (25% RDN through Vermicompost + 75% RDF), T3 (25% RDN through Farm Yard Manure + 75% RDF), T4 (25% RDN through Sheep manure + 75% RDF), T5 (25% RDN through Neem cake + 75% RDF),T6 (50% RDN through Vermicompost + 50% RDF), T7 (50% RDN through FYM + 50% RDF), T8 (50% RDN through Sheep manure + 50% RDF), T9 (50% RDN through Neem cake + 50% RDF). The results indicated that application of 25% RDN through farm yard manure + 75% RDF (T3) recorded significantly higher yield attributes viz., number of branches plant-1, number of siliqua plant-1, length of siliqua, number of seed siliqua -1 which was at par with T2 (25% RDN through Vermicompost + 75% RDF). Higher values of gross returns, net returns and benefit cost (B:C) ratio were obtained with application of 25% RDN through FYM + 75% RDF (T3) as the cost of cultivation of T3 was lesser compared to other treatments.
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YADAV, S. K., A. K. SRIVASTAVA, and T. K. BAG. "Effect of Integration of Fertilizers and FYM on Productivity and Soil Health of Rainfed Potato." Journal of AgriSearch 4, no. 1 (February 28, 2017). http://dx.doi.org/10.21921/jas.v4i1.7414.
Повний текст джерелаАнотація:
A field trial was conducted during two consecutive summer seasons of2012 and 2013 at ICAR-Central Potato Research Station, Shillong, Meghalaya to evaluate the integration of nutrient sources on productivity and soil health under rainfed potato cultivation in north eastern hill region of India. There were six treatments of integrated nutrient management viz., 100% Recommended dose of fertilizers,75% RDF through synthetic fertilizers and 25% recommended dose of nitrogen (RDN) through FYM, 50% RDF and 50% RDN through FYM, 25% RDF and 75% RDN through FYM, 100% RDN through FYM and control (no application of any sources of nutrients). The experiment was laid out in randomized block design with four replications. Nutrient management practices showed the significant improvement on growth and yield attributes of potato over control plot. Highest productivity of potato tubers (t/ha) was noticed with application of 75% RDF through synthetic fertilizers along with 25% RDN through FYM. Similarly, the maximum net return was associated with application of 75% RDF and 25% RDN through FYM under investigation. Application of 75% Recommended dose of nutrients through synthetic fertilizers in combination with 25% Recommended dose of nitrogen through FYM was more profitable for sustainable production of potato in the north eastern hill region of India.
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Shiyal, Vikram, H. K. Patel, P. H. Rathod, P. M. Patel, C. H. Raval, and A. P. Patel. "Integrated Nutrient Management on Fodder Dual Purpose Oat (Avena sativa L.)." International Journal of Plant & Soil Science, July 6, 2021, 80–86. http://dx.doi.org/10.9734/ijpss/2021/v33i1630525.
Повний текст джерелаАнотація:
Aim: To study the effect of integrated nutrient management (INM) on growth, yield and quality of dual purpose fodder oat.
Study Design: Randomized Block Design.
Place and Duration of Study: Anand Agricultural University, Anand during Rabi 2019-2021.
Methodology: The experiment was laid out in randomized block design with four replications. The experimental treatments were consisted of ten INM treatments viz., T1 (100% recommendation dose of fertilizer; RDF’ 80-40-00 kg NPK/ha), T2 (10 t FYM/ha + 100% RDF), T3 (castor cake/ha + 100% RDF), T4 (poultry manure/ha + 100% RDF), T5 (neem cake/ha + 100% RDF), T6 (5 t FYM + 25% RDN from FYM + 75% RDF + biofertilizer), T7 (5 t FYM + 25% RDN from castor cake + 75% RDF + biofertilizer), T8 (5 t FYM + 25% RDN from poultry manure + 75% RDF + biofertilizer), T9 (5 t FYM + 25% RDN from neem cake + 75% RDF + biofertilizer) and T10 (50% RDN from FYM + 50% RDN from castor cake + biofertilizer). Amount of castor cake, poultry manure and neem cake were applied based on 10 t FYM/ha equivalent N, i.e., respectively 1.45, 3.23 and 3.27 t/ha.
Results: The results revealed that quality parameters of fodder oat such as dry matter, dry matter yield, crude protein, ADF, NDF, crude fiber contents as well as ash content of green fodder and straw were found significant superior with application of T6 and T10 treatments. Similarly, NPK content and their uptake into the seed and straw were also found significantly higher with the same treatments. The physicochemical and biological properties of experimental field soil at harvest of oat crop were also considerably improved due to application of INM treatment as compared to initial soil nutrient status.
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Verma, Rahul, P. K. Singh, Vivek ., R. K. Naresh, M. Sharath Chandra, Durgesh Kumar Maurya, Vedvrat ., and Satya Prakash Gupta. "Effect of Integrated Nutrient Management (INM) Modules on yield, yield attributes and profitability of Indian mustard [Brassica juncea (L.)] in Western Uttar Pradesh." International Journal of Environment and Climate Change, December 20, 2021, 324–30. http://dx.doi.org/10.9734/ijecc/2021/v11i1230583.
Повний текст джерелаАнотація:
A field experiment was conducted to study the effect of integrated nutrient management (INM) modules on indian mustard (Brassica juncea L.) in Western U.P., variety Pusa Vijay at Crop Research Centre (CRC), Main Campus, Modipuram Meerut, during Rabi season, 2020-21. The soil of experimental field was sandy loam texture, alkaline in nature with pH, low in organic carbon (0.42%) and available nitrogen (181.60 kg/ha), available phosphors (16.50 kg/ha), available potassium (230.47 kg/ha) and available sulphur (7.38 kg/ha). Ten treatments of different nutrient management practices consisting T1 Control, T2 100% RDN (120 kg. N/ha), T3 75% RDN, T4 75% RDN + 25% through Vermicompost (VC), T5 75% RDN + 25% through Poultry Manure (PM), T6 75% RDN + 25% through Press Mud Compost (PMC), T7 75% RDN + 25% through [ VC , PM (1:1) ], T8 75% RDN + 25% through [VC, PMC (1:1) ], T9 75% RDN + 25% through [PM , PMC (1:1)], T10 75% RDN + 25% through [VC , PM, PMC (1:1:1)] were tested in randomized block design with three replications. The experimental results revealed that yield attributes (siliqua length, siliqua plant-1, seeds siliqua-1 and test weight), grain and stover yield (q ha-1). The increment in seed yield with application of 75% RDN + 25% through [VC, PM, PMC (1:1:1)] was 130.98 % over control. The maximum gross return and net return were recorded with the application of 75% RDN + 25% through [VC, PM, PMC (1:1:1)], however B:C ratio was lower than the use of RDF only but in application of vermicompost, press mud compost and poultry manure enhance soil fertility which improve the productivity and productivity of mustard.
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Jinjala, V. R., H. M. Virdia, N. N. Saravaiya, and A. D. Raj. "Effect of integrated nutrient management on baby corn (Zea mays L.)." Agricultural Science Digest - A Research Journal 36, no. 4 (November 25, 2016). http://dx.doi.org/10.18805/asd.v36i4.6470.
Повний текст джерелаАнотація:
A field experiment was conducted during rabi season of 2011-12 on heavy black soil to study the effect of integrated nutrient management on growth and yield of baby corn. The treatments comprising all possible combinations of five levels of nitrogen (chemical and vermicompost fertilizer) with and without bio-fertilizer (Azotobacter and PSB) were laid out in randomized block design with three replications. These were significantly higher with application of 100% RDN from chemical fertilizer with bio-fertilizer over 100% RDN from vermicompost. The cob and fodder yields significantly differed with different integrated nutrient management treatment. Significantly the higher growth and yield attributes yield and fodder yield were recorded with the application of 100% RDF from chemical fertilizer with bio-fertilizer. Application of 100% RDN from chemical fertilizer with biofertilizer was recorded higher net returns over 100% RDN from vermicompost (Rs. 220775/ha) and BCR (12.54).
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Deekshitha, D. K. D., Ch Sujani Rao, P. V. Subbaiah, M. Martin Luther, and V. Srinivasa Rao. "Direct and Residual Effect of Integrated Nitrogen Management on Productivity of Rice-maize Cropping System." International Journal of Plant & Soil Science, May 18, 2021, 28–39. http://dx.doi.org/10.9734/ijpss/2021/v33i1030470.
Повний текст джерелаАнотація:
Aim: To find out the direct and residual effect of application of organics, inorganics and their combination on yield and yield parameters of rice-maize cropping system.
Study Design: The experiment was laid out in randomized block design during kharif season and split plot design during rabi.
Place and duration of Study: At Agricultural college farm, Bapatla during 2018-19 and 2019-20.
Methodology: After the preliminary layout, paddy was sown in kharif and maize was sown in rabi season. Vermicompost and green leaf manure were applied two weeks before sowing of paddy. Treatments applied for paddy were considered as main plots and each main plot was divided into two sub plots during rabi.
Results: Higher grain yield, straw yield, drymatter production at tillering stage were recorded with the application of 50% RDN through vermicompost +50% RDN through inorganics (T9) during both the years of study. However, in succeeding maize, the kernel yield, straw yield and yield attributing characters (drymatter, cob length and test weight) were significantly highest in the treatment which received 75% RDN through green leaf manure+ 25% RDN through inorganic (T5). Among the fertilizer levels applied to maize, S2 (100% RDF) recorded significantly higher dry matter production over S1 (50% RDF) at all the stages of crop growth and during two years of experimentation.
Conclusion: Substitution of 50 % N through vermicompost improved rice yield and yield attributes whereas substitution of 75% N through GLM have shown better residual effect in terms of improvement of yield and yield attributing characters of maize. Among the subplots application of 100% RDF significantly increased the yield when compared to 50% RDF.