Дисертації з теми "Rat placenta"
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Robinson, N. R. "Calcium transfer across the rat placenta." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234186.
Повний текст джерелаFreitas, Murilo Rodrigues Barbosa de. "O efeito do selênio em ratas Wistar prenhas infectadas pela cepa Y de Trypanosoma cruzi." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-31102014-102620/.
Повний текст джерелаThe selenium (Se) is an essential micronutrient in the diet ofmammals and has an important role in the immune function. A range of 25 selenoproteinshas Sein its structure and most of them in the form of amino acid selenocysteine, being this element involved in the in maintenance of the antioxidant defense. Diet with Se is beneficial in the treatment of diseases correlated with high levels of oxidative stress, like Chagas\' disease, a neglected illness caused by Trypanosoma cruzi. The objective of this study was to evaluate the effects of selenium in the immune response of pregnant Wistar rats infected withtheY strain of T. cruzi. Se treatment triggered enhanced fetal weight and length and placental diameter and weight. It was observed decreased parasitemia. No significant alterations in NO concentrations and amastigote nests in heart were observed. The histological evaluation of placenta displayed an enhanced number of amastigote nests in infected and Se treated animals. The reduction of pro-inflammatory cytokines and T cell populations triggered a Th-2 immune response, which is the hallmark of the gestation period. This fact probably led to the raise in parasite nests in placenta of infected and Se treated animals. So it is possible that the Se supplementation during pregnancy could impair the local placental immune response. Further studies are needed to assess the interaction between selenium and the acute Chagas\' disease during pregnancy.
Taylor, Louise. "Comparative analyses of ABC transporters and metabolising enzymes in human and rat placental models." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/comparative-analyses-of-abc-transporters-and-metabolising-enzymes-in-human-and-rat-placental-models(3daff296-0364-4e4b-89f8-337dac6dbf10).html.
Повний текст джерелаCarter, Wayne Grant. "Site specificity and purification of an insulin receptor associated serine kinase from human placenta and rat liver." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295913.
Повний текст джерелаCisse, Ouma. "Conséquences transgénérationnelles d'une programmation fœtale par dénutrition maternelle et d'un régime hyperlipidique chez le rat : focus sur le placenta." Phd thesis, Université du Droit et de la Santé - Lille II, 2013. http://tel.archives-ouvertes.fr/tel-01064268.
Повний текст джерелаCisse, Ouma. "Conséquences transgénérationnelles d’une programmation fœtale par dénutrition maternelle et d’un régime hyperlipidique chez le rat : focus sur le placenta." Thesis, Lille 2, 2013. http://www.theses.fr/2013LIL2S005/document.
Повний текст джерелаThe concept of DOHaD (Developmental Origins of Health and Disease) which derives from the theory of Barker, replace the origin of metabolic diseases in adults during fetal development and / or perinatal period. Many epidemiological data indicate that maternal dysnutrition (undernutrition, overnutrition) affects fetal growth showing abnormal birth weight (intrauterine growth retardation : IUGR / large birth weight macrosomia) and predispose individuals to development of metabolic diseases. To better understand the mechanisms invovle in transmission of the metabolic vulnerability from one generation to another, we have developed a model combining transgenerational rat fetal programming in the F0 by maternal undernutrition (model FR30) and dysnutrition in F1 with an hyperlipidic diet.Our results show that dietary restriction of 70% throughout pregnancy (FR30 model) contributes to emphasize development of metabolic syndrome traits into female F1 progeny. F1 females from undernourished mothers have an adult glucose intolerance and hyperleptinemia. These metabolic disturbances will be increase by a high fat diet (HF) but will not lead to obesity in female F1 regardless of the mother (F0) diet/statut. This can be explain by the low palatability of the diet, and the lack of carbohydrates largely involve in the development of obesity. These F1 phenoypes conduce to different F2 phenotypes at birth depending of fetal growth trajectory.Newborns from F1 mothers C or FR with HF diet during pregestation and gestation (C HF-HF and FR HF-HF) present IUGR. In contrast, infants born from F1 undernourished mothers with HF diet during pregestation following by standard diet during pregnancy (FR HF-S) show macrosomia. Like metabolic and hormonal disturbances into F1 mothers can not explain themselves the occurrence of these phenotypes, we studied the organ at the interface between maternal and fetal compartments in charge of the crosstalk between mother and fetus : the placenta. Morphological and molecular analysis indicate that placenta is not only sensitive to metabolic changes in the mother, but also able to adapt to the fetus needs. We observe strong correlation between gene expression (decrease or increase) and phenotype (IUGR/macrosomia) with gender specificity.Our work therefore suggests that IUGR or macrosomia phenotypes are not only depending on maternal hormonal and metabolic abnormalities but also in the sex-specific placental gene response to these exposure
Hering, Lydia. "Die Bedeutung des Renin-Angiotensin-Systems im Tiermodell für Präeklampsie." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16550.
Повний текст джерелаDysregulation of the renin-angiotensin-system is important in preeclampsia, a pregnancy specific disorder, characterized by high blood pressure and albuminuria. Aim of this study is to characterize the effects of circulation and uteroplacental renin-angiotensin-system during pregnancy in a rat model. Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human renin gene develop preeclampsia, whereas those of the opposite cross do not. We used this model to study the role of angiotensin II in trophoblast invasion, which is shallow in human preeclampsia but deeper in this model. We investigated the following groups: preeclampsia rats, opposite-cross rats, angiotensin II–infused rats and control rats. Angiotensin II infusion increased only circulating angiotensin II levels, opposite cross influenced only uteroplacental angiotensin II and preeclampsia rats showed increased circulating and uteroplacental angiotensin II. Blood pressure and albuminuria occurred in the models with high circulating angiotensin II but not in other models. Control rats showed physiological heart hypertrophy during pregnancy whereas pathological heart hypertrophy occurred in preeclampsia rats. High uteroplacental angiotensin II influenced deep trophoblast invasion in distant spiral arteries whilst the effect of circulating angiotensin II was more diffuse. We then studied human trophoblast cell line and villous explants derived from first-trimester pregnancy. Local angiotensin II dose-dependently increased migration, invasion and motility. The data suggest that angiotensin II stimulates trophoblast invasion in vivo in the rat and in vitro in human cells, a hitherto fore unrecognized function.
Chartrel, Nicolas. "Identification de quelques facteurs impliqués dans l'induction de l'hypotrophie foetale chez la rate rendue expérimentalement diabétique." Rouen, 1989. http://www.theses.fr/1989ROUES016.
Повний текст джерелаNash, Peppi. "Experimental and Clinical Studies of Oxidative Stress in Pre-Eclampsia." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7717.
Повний текст джерелаImpaired placentation and oxidative stress are proposed to play major roles in the pathogenesis of pre-eclampsia (PE). It has recently been pointed out that PE might be more than one disease and may have several different pathogeneses. This thesis describes a new animal model for PE and examines the role of oxidative stress in early respective late onset PE.
The effects of Suramin injections on day 10 and 11 of pregnancy were investigated in normal and diabetic rats of two strains (U and H), with or without additional vitamin E treatment. Suramin caused placental dysfunction in both rat strains: foetal growth restriction, increased resorption rate, reduced placental blood flow, and decreased maternal blood volume in the placenta. In the U strain Suramin also caused maternal hypertension and reduced renal blood flow. Oxidative stress in the Suramin treated rats was indicated by increased levels of isoprostane 8-iso-PGF2α in the placenta. Antioxidative treatment with vitamin E partly protected against the effects of Suramin. Streptozotocin-induced diabetes seemed to cause similar placental effects as Suramin, and in the diabetic rats the additional effects of Suramin were only moderate. In conclusion, Suramin-injected pregnant rats constitute a valid animal model for placental dysfunction (U and H rats) and PE (U rats).
Oxidative stress was estimated in women with early onset (≤ 32 weeks) or late onset (≥ 35 weeks) PE, in normotensive pregnant women of respective gestational length, and in healthy non-pregnant women. The ratio of PAI-1/PAI-2 was measured in serum, and the amount of isoprostane 8-iso-PGF2α was measured in placenta, serum, and urine. The ratio of PAI-1/PAI-2 and placental isoprostane levels were higher in women with early onset PE compared with all other groups. Serum levels of isoprostane were similar between groups. Urinary levels of isoprostane were similar in all pregnant women, but lower in non-pregnant women. These data indicate that pregnancy increases general oxidative stress, and that early onset, but not late onset PE, causes increased oxidative stress also in placental tissue. The pathogeneses of early and late onset PE are, therefore, not likely to be identical.
Lippi, Luciana Lucinio. "Estudo da toxicidade da Ipomoea carnea em ratas durante o período perinatal. Avaliação dos possíveis efeitos lesivos no tecido placentário." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-17122009-173640/.
Повний текст джерелаIpomoea carnea is a toxic plant widely distributed in Brazil and other tropical countries. During periods of drought, animals graze on this plant which grows even in the presence of adverse climatic conditions. After prolonged periods of plant intake, the animals exhibit a variety of clinical signs as depression, general weakness, body weight loss, staggering gait, muscle tremors, ataxia, posterior paresis, and paralysis. Two kinds of toxic principles were isolated from the plant, the nortropane alkaloids calystegines B1, B2, B3 and C1 and mainly the indolizidine alkaloid swainsonine. The latter alkaloid is a potent inhibitor of two distinct intracellular enzymes, the lysosomal α-mannosidase which results in lysosomal accumulation of incompletely processed oligosaccharides moieties inside vacuoles, which progresses to cellular function loss and, ultimately, to cell death and the Golgi mannosidase II enzyme causes alteration of the N-linked glycoprotein process, modifying the glycoprotein synthesis, processing and carrier. Histologically, cellular vacuolization of Purkinje cells, thyroid follicles, exocrine pancreas, liver and kidney cells have been observed. Recently, many studies in our laboratory have shown that Ipomoea carnea have teratogenic effects in rats, goats and rabbits. However, it is not known yet if the alterations observed in the fetuses are due to alterations in the placenta or if they can be directly related to the transplacental transfer of the active principle. The present study was performed to evaluate the effects of Ipomoea carnea in the placental tissue and in the litter of female rats treated during. Pregnant rats of the experimental groups were treated orally by gavage, once a day from GD6 to GD19, with 1,0; 3,0; 7,0 g/kg of Ipomoea carnea AF. The control and peer-feeding group received tap water by gavage. Total body weight gain, water and food consumption were measured each three days during the experimental period. At the end of pregnancy period some animals were, for cesarean section, mainly for evaluation of placental tissue and the other animals followed the pregnancy until the birth to the term analysis of offspring. From the animals that came from the cesarean section, were collected the fetuses and their placental, those being collected for anatomopathological, histochemistry (lectins and TUNEL) and morphometric analysis, as the fetuses measured about their sizes and weight and assessed to external malformation and bone and visceral analysis and performed the reproductive performance of those females. The pregnants that followed up to the birth of their offspring, which were assessed regarding their physical and reflexology development daily and at days 4, 8, 15 e 22 of lactation, an offspring of each mother was euthanized so representatives fragments of the liver, kidney, SNC and pancreas could be collected for a histopathological assessment, this procedure was also performed at those mothers submitted to the cesarean section at the 20th pregnancy day, as well as at the breastfeeding at the 22nd lactation day. The obtained results clearly show the teratogenic potential produced by the Ipomoea carnea, because both the fetuses as the pups had some congenital anomalies, decrease in birth weight and the delayed negative geotaxis. At both the mother and offsprings liver and kidneys was observed a vacuolar degeneration, showing the maternal and fetal toxicity promoted by the plant exposed during the pregnancy period. An important data noted here refers to the placental tissue assessment, which showed some histopathological alterations, as the labirinth zone thickening and the reduction of the junctional zone thickness, however the vacuolar degeneration was not observed in this organ, although when performed the lectin-histochemistry technique, it was possible to observe the accumulation of some sugars in some cells located at several regions of the placenta, this way showing that this tissue has also suffered some injury promoted by the plant action, not being possible anymore to consider this organs just as a plac of passage for these toxic active principle.
Dunton, Anne. "The 'giant' yolk sac : an in vitro model for studying early placental transport." Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/34333.
Повний текст джерелаCooper, Andrea Claire. "The renin angiotensin system in the human placenta throughout gestation." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312204.
Повний текст джерелаMatos, Marcelo Alexandre de. "Efeitos do ciclamato de sódio na placenta de ratas: estudo morfométrico." Faculdade de Medicina de São José do Rio Preto, 2006. http://bdtd.famerp.br/handle/tede/8.
Повний текст джерелаObjective: To evaluate the effects of sodium cyclamate on the rat placenta by its administration in the period of embryogenesis. Method: The sodium cyclamate was administered by intraperitoneal route in rats of the treated group at the dose of 60 mg/kg, from the tenth to fourteenth day of gestation, while the equivalent volume of saline solution was given to the control group, by the same route. On the twentieth day of pregnancy, 10 fetuses (5 from each group) were chosen at random for study. The technique of cariometry was utilized for evaluation of nuclear parameters of cells in deciduous and spongy layers, and of chorionic villi in the rat placenta. Results: The weights of treated fetuses and their placentas were less than those of the control group, while umbilical-cord length in the treated group was shorter than that in control fetuses. There were no alterations in the deciduous layer. In the placental spongy layer were found alterations of the following parameters: major diameter, mean diameter, perimeter, area, volume, the volume/area ratio and eccentricity. The altered parameters in chorionic villi were the following: mean diameter, perimeter, area, volume, the volume/area ratio. Conclusions: This study demonstrated placental alteration with the use of cyclamate by the pregnancy rat, and its repercussion in fetal weight and umbilical-cord length.
Objetivo: Avaliar os efeitos do ciclamato de sódio na placenta de ratas com sua administração no período da embriogênese. Método: Foi administrado por via intraperitoneal nas ratas do grupo tratado a dose de 60 mg / Kg de ciclamato de sódio, do décimo ao décimo quarto dia de gestação, e volume equivalente de solução salina no grupo controle, pela mesma via. No vigésimo dia de prenhez, 10 fetos (5 de cada grupo) foram escolhidos ao acaso para estudo. Foi utilizada a técnica de cariometria para avaliação dos parâmetros nucleares das células das camadas decídua, esponjosa e das vilosidades coriônicas da placenta de ratas. Resultados: O peso dos fetos tratados e de suas placentas foi menor que os do grupo controle, assim como o comprimento do cordão umbilical do grupo tratado foi mais curto que o dos fetos controles. Não houveram alterações na camada decídua. Na camada esponjosa placentária ocorreram alterações dos seguintes parâmetros: diâmetro maior, diâmetro médio, perímetro, área, volume, relação volume / área e excentricidade. Os parâmetros alterados nas vilosidades coriônicas foram os seguintes: diâmetro médio, perímetro, área, volume e relação volume / área. Conclusões: Este estudo demonstrou alteração placentária com o uso de ciclamato pela rata grávida, e sua repercussão no peso fetal e comprimento do cordão umbilical
Hassanein, Mohamed. "Biochemical and functional characterization of a novel placental protease, cathepsin P, in rat trophoblasts." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 148 p, 2007. http://proquest.umi.com/pqdweb?did=1654487491&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Повний текст джерелаKaihola, Helena. "The Effects of SSRI Treatment on Human Placenta and Embryo." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248527.
Повний текст джерелаChura, Lindsay R. "The effect of chronic and acute maternal stress on expression of placental barrier genes in the rat /." Connect to online version, 2006. http://ada.mtholyoke.edu/setr/websrc/pdfs/mhc/2006/143.pdf.
Повний текст джерелаLeone, Francesca Marie. "Placental restriction impairs glucose homeostasis in the adult rat, independently of adiposity and circulating free fatty acids /." Title page and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09HS/09hsl583.pdf.
Повний текст джерелаBojja, Aruna Sri. "Functional characterization of placental cathepsins." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 81 p, 2009. http://proquest.umi.com/pqdweb?did=1885754561&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Повний текст джерелаBinsalamah, Ziyad. "Intramyocardial sustained delivery of Placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104785.
Повний текст джерелаContexte: Les résultats de l'ischémie myocardique aiguë dans la formation de cicatrices avec dilatation ventriculaire et l'insuffisance cardiaque par la suite. Le facteur de croissance placentaire (PlGF) est signalé pour stimuler l'angiogenèse et améliorer la fonction cardiaque. Dans cette étude, nous avons émis l'hypothèse que l'injection intramyocardique de PlGF contenus dans des nanoparticules peuvent être libérés sur le site d'action pour une période prolongée en tant que mécanisme durable à libération lente de protection qui accélère la récupération du myocarde dans un modèle de rat de cardiomyopathie ischémique. Méthodes: L'étude a été menée sur 35 rats Lewis. Les rats ont été répartis au hasard en quatre groupes: le groupe de contrôle I (n=10) a reçu des nanoparticules de chitosan-alginate vides; le groupe de traitement II (n=10) a reçu le PlGF, et le groupe de traitement III (n=10) a reçu le PlGF contenu dans les nanoparticules de chitosan-alginate; qui avaient tous la ligature coronaire et l'injection de la matière dans la zone péri-infarctus, et enfin un groupe fictif utilisé (n=5). L'échocardiographie transthoracique a été réalisée pour chaque rat comme base de référence avant la chirurgie, après la ligature à 2 jours, une semaine, 4 semaines, et à 8 semaines. Le raccourcissement du ventricule gauche fractionné (FRVG) et la fraction d'éjection ventriculaire gauche (FEVG) ont été mesurés à ces intervalles de temps. ELISA a été utilisé pour mesurer le taux sérique de TNF-α, IL-6 et IL-10 à 8 semaines. Les cœurs ont été colorés au trichrome de Masson pour l'analyse de la surface de cicatrice. Résultats: 8 semaines après la ligature coronaire, le groupe I avait une FEVG de 27.6±7.5%, contre 47.1±2.6% dans le groupe II, et 56.6±3.7% dans le groupe III. Les groupes II et III ont montré une amélioration statistiquement significative (P < 0.01) de la FEVG et FRVG par rapport au groupe I. La différence entre les groupes II et III a également été statistiquement significative (P < 0.01). Le pourcentage du ventricule gauche marqué à la section mi-papillaire était 32.7±4% dans le groupe I, contre 28.4±3% dans le groupe II, et 24.5±2.6% dans le groupe III. La différence entre le groupe I par rapport au groupe II, et le groupe II versus III était statistiquement significative (P < 0.05). Cet effet a été associé à une diminution significative des cytokines pro-inflammatoires (TNF-α, IL-6) et une augmentation de la cytokine anti-inflammatoire (IL-10) dans le groupe III par opposition au groupe II. Conclusion: L'utilisation de nanoparticules en tant que véhicule pour la livraison du PlGF par opposition à l'application directe du facteur de croissance post-infarctus aigu du myocarde a entraîné une augmentation significative de la fonction ventriculaire gauche, une diminution de la zone de cicatrice, une diminution des cytokines pro-inflammatoires (TNF-α, IL-6) et une augmentation de la cytokine anti-inflammatoires (IL-10). Ainsi, les nanoparticules peuvent être utilisées pour fournir un mécanisme de protection soutenu à libération lente de la thérapie PlGF, renforçant les effets positifs du facteur de croissance dans le cadre de l'ischémie myocardique.
Rhodes, Katrin Elisabeth. "Hematopoietic stem cell development in placental vasculature." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1997626891&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Повний текст джерелаChang, Miao. "Cell type specific regulation of human placenta growth factor gene transcription /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1597612421&sid=3&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерела"Department of Molecular Biology, Microbiology and Biochemisty." Includes bibliographical references (p. 123-150). Also available online.
Sun, Yuxiang. "Identification and characterization of cis- and trans-acting factors involved in the expression of the rat placental lactogen II gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0027/NQ51670.pdf.
Повний текст джерелаWeis, Simone Nardin. "Efeitos de compostos orgânicos de selênio sobre o desenvolvimento intra-uterino da prole de ratas wistar." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/11081.
Повний текст джерелаSelenium (Se) is an essential trace element for man and is known for its role in regulating growth and development of the fetus and newborn. It is well known that Se deficiency is related to miscarriages and pre-term deliveries. However, it is established that Se compounds, depending of dose, can be highly toxic to several species of animals. The organoselenium compounds, diphenyl diselenide [(PhSe)2] and 3 3- ditrifluoromethyldiphenyl diselenide [(F3CPhSe)2] were the target of this study since they present important pharmacological properties. Therefore, it is necessary to dtudy the effects of these compounds on the embryofetal development. The purpose of the present study was to evaluate the effects of (PhSe)2 and (F3CPhSe)2 administration during the organogenesis period of intrauterine development of Wistar rats. Dams were subcutaneously exposed to (PhSe)2 (1.5, 3.0 or 6.0 mg/kg) or only vehicle (canola oil), from days 6 to 15 of gestation (Article). External and internal fetal examination was performed at gestational day 20. No mortality was observed in fetuses or dams at any (PhSe)2 treatment. A decrease in maternal body weight gain (corrected) was found in all (PhSe)2 groups and also an increase in the liver relative weight were observed in these dams, indicating maternal toxicity. Exposure to (PhSe)2 produced significant changes in fetal body weight and biometry. Furthermore, we verify an increase in the incidence of skeletal alterations of fetuses of all (PhSe)2 doses tested, however, these alterations were considered variations that are generally reversible and is unlikely to adversely affect survival or health. (PhSe)2 was capable to cause some morphological modifications on placentas such as vascular congestion, an increase in leucocyte infiltration and phagocytosis. These effects might have contributed with adverse reproductive outcomes observed in the progeny. In the second work presented in this dissertation (Manuscript), pregnant rats were given, via intragastric intubation, 1, 5 or 10 mg/kg of (F3CPhSe)2 or vehicle (canola oil), from days 6 to 15 of gestation. The parameters evaluated were the same of the first study. Administration of 5 and 10 mg/kg of (F3CPhSe)2 decreased maternal weight gain during pregnancy and this was accompanied by a reduced food consumption in the higher dose. Furthermore, there was an increase in liver absolute and relative weight of dams given the higher dose. These data confirm the liver as the primary target organ for Se compounds exposition. Differently from (PhSe)2 exposure, (F3CPhSe)2 administration did not alter fetal body weight and biometry. However, the compound caused embryolethality in the higher dose tested. This effect seems to be all or none since it led to totally resorption of some litters and the others were not affected by the compound. In this dose level, it was also observed a number of skeletal variations that, equally to (PhSe)2 study, seems unlikely represent survival risks. The placentas morphological analysis revealed that exposure to (F3CPhSe)2 was able to alter placental morphology. On the basis of results mentioned above, we conclude that maternal exposure to (PhSe)2 and (F3CPhSe)2 did not cause externally visible malformations but they were able to increase fetuses skeletal alterations incidence, without affecting fetuses survival. Organoselenium compounds also alter placental morphology that could contribute with adverse reproductive outcomes observed on the progeny.
O selênio (Se) é um elemento traço essencial para humanos e desempenha importante função no crescimento e desenvolvimento de fetos e recém-nascidos. Sabese que a deficiência desse elemento pode ocasionar abortos e nascimentos prematuros. Entretanto, os compostos de Se, dependendo da dose, podem ser tóxicos para diversas espécies de animais. Os compostos orgânicos de selênio, disseleneto de difenila [(ØSe)2] e disseleneto de 3'3-ditrifluormetildifenila [(F3CØSe)2], foram os alvos deste estudo, visto que possuem importantes propriedades farmacológicas. Com isso, faz-se necessário o estudo dos efeitos destes compostos sobre o desenvolvimento embriofetal. O objetivo deste estudo foi avaliar os efeitos da administração de (ØSe)2 e (F3CØSe)2 durante o período da organogênese do desenvolvimento intra-uterino de ratas Wistar. No primeiro trabalho, as ratas prenhas foram expostas ao (ØSe)2 (1,5; 3,0 ou 6,0 mg/kg) ou ao seu veículo (óleo de canola) via injeção subcutânea, do 6º ao 15º dia de gestação (Artigo). No 20° dia de gestação foi realizada uma laparotomia para a retirada dos fetos e a observação do aparecimento de malformações morfológicas externas e esqueléticas. Não foram observadas mortes maternas e fetais nos grupos expostos ao (ØSe)2. A exposição causou uma diminuição do ganho de peso corporal materno (corrigido) nas duas maiores doses testadas, além de um aumento no peso relativo do fígado destas ratas, indicando que o composto causou toxicidade materna. A exposição ao ( Se)2 alterou significativamente os parâmetros de desenvolvimento avaliados (peso e medidas corporais fetais). Além disso, verificou-se um aumentou de incidência de alterações na ossificação do esqueleto desses fetos, em todas as doses avaliadas, porém, estas alterações são consideradas variações que são geralmente reversíveis e parecem não apresentar riscos à vida. Observou-se também que as placentas das ratas que foram expostas ao (ØSe)2 apresentavam alterações na morfologia, tais como, congestão vascular, aumento da infiltração leucocitária e uma intensa atividade fagocítica. Estes efeitos parecem ter contribuído para os efeitos adversos encontrados nas proles analisadas. No segundo trabalho apresentado nesta dissertação, as ratas prenhas foram expostas ao (F3CØSe)2 (1; 5 ou 10 mg/kg) ou ao seu veículo (óleo de canola) através de entubação gástrica, do 6º ao 15º dia de gestação (Manuscrito). Foram avaliados os mesmos parâmetros do primeiro trabalho. A administração das doses de 5 e 10 mg/kg de (F3CØSe)2 causou uma diminuição de ganho de peso corporal materno, acompanhada de uma diminuição de consumo de alimento na maior dose administrada. Além disso, as ratas que receberam a maior dose do composto tiveram um aumento do peso do fígado (absoluto e relativo). Estes dados confirmam que o fígado é o órgão alvo da exposição a compostos de Se. Diferentemente da exposição ao (ØSe)2, a administração de (F3CØSe)2 não alterou o peso e as medidas corporais fetais. Entretanto, o composto causou embrioletalidade na maior dose testada. Este efeito parece ser do tipo tudo-ounada, uma vez que levou à reabsorção total de metade das ninhadas estudadas, sendo que a outra metade não foi afetada pelo composto. Nesta dose também foram observadas variações esqueléticas, que igualmente ao estudo com (ØSe)2 parecem não apresentar riscos à vida. A análise morfológica das placentas também revelou que a exposição ao (F3CØSe)2 foi capaz de alterar de forma significativa a morfologia da placenta. Portanto, com base nos resultados encontrados, concluímos que a exposição materna ao (ØSe)2 e ao (F3CØSe)2 não provocou o aparecimento de malformações externas visíveis, porém, aumentou a incidência de alterações esqueléticas nos fetos, alterações essas que não afetam a sobrevivência dos mesmos. A exposição aos organocalcogênios também modificou a morfologia das placentas o que pode ter contribuído para o atraso no desenvolvimento intra-uterino observado nas proles.
Leandro, Sandra Márcia. "Sobrecarga e restrição de sal na dieta durante a gestação em ratas Wistar: efeitos sobre o sistema renina-angiotensina, função renal, resistência à insulina e pressão arterial." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-08012007-172716/.
Повний текст джерелаMany epidemiological studies have linked diseases in adulthood, such as type-2 diabetes and hypertension, to adverse intrauterine environment during fetal life. Distinct factors related to dietary habits, such as salt intake, may have a major impact on the perinatal period. Recently, we have demonstrated that low-salt diet (LSD) during pregnancy is associated with low birth weight and diseases during adulthood. The aim of this study was to evaluate the effect of LSD and high-salt diet (HSD) during pregnancy in rats. Female Wistar rats were fed with LSD, normal-salt diet or HSD since 8 weeks of age and matted with 12 weeks of age. These animals were studied at the third week of gestation and one additional group of virgin rats was evaluated as a control for the gestation effect. Placenta and fetus weight and uterine blood flow were lower and peripheral vascular resistance was higher in the LSD group. In the placenta from HSD rats, higher lipid peroxidation and AT1 receptor mRNA were observed. In conclusion, fetal weight, placenta weight and uterine blood flow are influenced by the degree of salt consumption during pregnancy.
Maheshwari, Vatsala. "Potential role of NF-[kappa]B in regulation of human placenta growth factor (PlGF) in trophoblast /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1650513211&sid=4&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерела"Department of Molecular Biology, Microbiology and Biochemisty." Includes bibliographical references (p. 98-113). Also available online.
Johnson, Gabriel Paul. "Early embryology of Ceratopteris richardii and immunocytochemistry of placental transfer cell wall ingrowths /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1597619681&sid=11&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерелаDe, Blasio Miles Jonathon. "Placental restriction of fetal growth increases growth rate and sensitivity to insulin and insulin-like growth factor 1 (IGF-1) after birth in sheep /." Title page and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09SB/09sbd286.pdf.
Повний текст джерелаSpine title: Fetal gowth restriction increases insulin and IGF-1 sensitivity in neonatal sheep. Bibliography: leaves 21-24.
Arnold, Daniel Robert. "Regulation of trophoblast development in the bovine embryo." Thèse, [Montréal] : Université de Montréal, 2005. http://proquest.umi.com/pqdweb?index=0&did=1221731981&SrchMode=1&sid=1&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1191513626&clientId=48948.
Повний текст джерелаTitre de l'écran-titre (visionné le 4 oct. 2007). "Thèse présentée à la Faculté des études supérieures en vue de l'obtention du grade de Philosophiae Doctor (Ph.D.) en sciences vétérinaires option reproduction" Paraît aussi en version papier et en version microforme.
Banet, Amanda Inez. "Evolutionary diversification of reproductive modes in livebearing fishes." Diss., [Riverside, Calif.] : University of California, Riverside, 2009. http://proquest.umi.com/pqdweb?index=0&did=1957301301&SrchMode=2&sid=4&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1268858219&clientId=48051.
Повний текст джерелаIncludes abstract. Available via ProQuest Digital Dissertations. Title from first page of PDF file (viewed March 17, 2010). Includes bibliographical references. Also issued in print.
Lombardi, Lopes Flavia. "Regulation of vascular endothelial growth factor during the peri-implantation period in the American mink mustela vison /." Thèse, [Montréal] : Université de Montréal, 2005. http://proquest.umi.com/pqdweb?index=4&did=1155571621&SrchMode=1&sid=3&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1191512564&clientId=48948.
Повний текст джерелаTitre de l'écran-titre (visionné le 4 oct. 2007). "Thèse présentée à la Faculté des études supérieures en vue de l'obtention du grade de Philosophiae Doctor (Ph.D.) en sciences vétérinaires option reproduction" Paraît aussi en version papier et en version microforme.
Possignolo, Luiz Fernando 1987. "Efeito da ingestão crônica de dieta hiperlipídica no metabolismo de ratas, e sobre a expressão de SR-BI e ABCA1 na placenta, intestino delgado, fígado e rins da prole destes animais = Effect of high fat diet chronic ingestion on the metabolism of female rats, and on the SR-BI and ABCA1 expression in the placenta, small intestine, liver and kidney of the offspring." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309926.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-21T06:22:30Z (GMT). No. of bitstreams: 1 Possignolo_LuizFernando_M.pdf: 4767580 bytes, checksum: b843458e4c7049fc29741e4aca9f918d (MD5) Previous issue date: 2012
Resumo: Devido ao maior consumo de alimentos ricos em gordura e um estilo de vida mais sedentário, houve um aumento na incidência de desordens metabólicas relacionadas ao metabolismo lipídico como a resistência à insulina, dislipidemias, e sua associação com doenças cardiovasculares. A alimentação materna desequilibrada, durante a gestação e lactação, pode predispor a prole à doenças durante a vida adulta. Alguns transportadores como o Scavenger Receptor class B type I (SR-BI) e ATP-binding cassette transporter A1 (ABCA1) são descritos como responsáveis pela captação de colesterol e transporte deste a partir de lipoproteínas, principalmente no transporte reverso de colesterol, sendo denominados receptores antiaterogênicos podendo modificar seu padrão de expressão frente a uma dieta hiperlipídica. Ratas Wistar receberam dieta hiperlipídica (DHL) ou dieta padrão (CTL) desde o desmame, até a lactação. Após o desmame a prole de machos recebeu a dieta padrão até a 16ª semana de vida. Nas mães quanto e na prole foram analisados os seguintes parâmetros: ingestão alimentar, ganho ponderal, perfil lipídico e glicídico. Na prole foi estudada a expressão e localização de ABCA1 e SR-BI na placenta, no rim, fígado, e intestino delgado em animais com 17 dias pré-natal (E17), 12 dias pós-natal (PN12d) com 8 e 16 semanas pós-natal (PN8s e PN16s). As mães DHL apresentaram: 1) maior ingestão calórica com menor ganho ponderal; 2) aumento glicêmico associado à menor produção de insulina nos três períodos estudados e, 3) aumento nos níveis séricos de triglicérides em M8s. A prole de mães DHL apresentaram menor massa corporal desde E17 até PN8s, sem que tenha havido diferenças ponderais e na ingestão de ração. PN8s e PN16S apresentaram menor captação tissular de glicose associada à hiperinsulinemia, e aumento nos níveis séricos de triglicérides com PN16S. Não houve alterações nos níveis de colesterol e HDLcolesterol. Não foi observada alteração na expressão de SR-BI e ABCA1 no intestino delgado, placenta enquanto no fígado houve uma queda tempo-dependente para ambos transportadores. No rim da prole DHL aos PN12d e PN16s observou-se maior expressão de ABCA1. Este estudo mostrou que o consumo materno crônico de uma dieta hiperlipídica causa alterações metabólicas nas mães e predispõe a prole, a modificações no metabolismo lipídico e glicídico, além de elevação da expressão de ABCA1 no rim
Abstract: Due to the abundance and accessibility to foods high in fat and a more sedentary lifestyle, there is an increased incidence of metabolic disorders related to lipid metabolism such as insulin resistance, dyslipidemia, and a high correlation with cardiovascular disease. The unbalanced maternal diet during pregnancy and lactation predisposes the offspring to diseases during adult life. Some carriers such as scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) are described as responsible for raising cholesterol and transporting it to and from lipoproteins, due the participation in the reverse cholesterol transport, these receptors are called antiatherogenic and are subject to change its pattern of expression when exposed to a high fat diet. Female Wistar rats were fed a diet (HFD) or a standard chow (CTL) from weaning, during pregnancy and lactation. After weaning the male offspring was exposed to a standard chow until the 16th week of life. Both the dams and the offsprings food intake were monitored, weight gain, lipid profile and glucose level. It was analyzed in the offspring the expression and localization of ABCA1 and SR-BI in the placenta, kidney, liver, and small intestine in animals at 17º prenatal day (E17), 12 days post-natal (PN12d), 8 and 16 postnatal weeks (PN8s PN16s respectively). DHL dams had a higher intake of calories in the diet, but the weight was smaller, they had higher blood glucose due to decreased production of insulin in the pre-pregnancy (m8s), during pregnancy (M17g) and lactation (M15l) and a higher triglyceride level in m8s. The offspring of dam fed a high fat diet had lower weight since E17 until PN8s, with no differences in weight gain and food intake. PN8s and PN16s had lower glucose uptake and hyperinsulinemia, and high triglycerides with PN16s, no changes were observed in cholesterol and HDL-cholesterol levels. There were no changes in the expression of SR-BI and ABCA1 in the small intestine, placenta and liver, however there was a decrease over the age for both receptors, and kidney of the offspring and DHL PN12d PN16s showed higher expression of ABCA1. The present study showed that chronic consumption of high fat diet causes metabolic changes in dams and predisposes offspring to changes in lipid and glucose metabolism of the offspring, increasing the expression of ABCA1 in the kidney
Mestrado
Biologia Estrutural, Celular, Molecular e do Desenvolvimento
Mestre em Fisiopatologia Médica
Hernández, Velasco Silvia Clara. "Genetics of litter size and prenatal survival in pigs." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6467.
Повний текст джерелаBuffat, Christophe. "Retard de croissance intra utérin et origine précoce des maladies de l'adulte : mécanismes physiopathologiques et moléculaires." Paris 7, 2008. http://www.theses.fr/2008PA077053.
Повний текст джерелаIntra-uterin growth restriction (iugr) and postnatal overfeeding is an important cause of the metabolic syndrome and cardiovascular diseases in adulthood. However, the detailed mechanisms of such programming are still incompletely known. Two experimental approaches in the rat were used in this work of thesis: first, protein depletion during the gestation of rat females has been widely used as a model for human. A transcriptome analysis of control and protein-deprived rat placentas and kidneys was used to better understand the molecular basis of early origin of the diseases in adulthood. Our approach permitted the proposition of hypotheses on a hierarchy of gene inductions/repressions leading to massive transcriptional alterations in the iugr placenta and kidney. Moreover, postnatal growth via renal effects other than glomerular number reduction are likely to contribute to arterial hypertension induced by early postnatal overfeeding. Thus, the comprehension of the mechanisms imply in the early origin of cardiovascular and metabolic diseases in adulthood, currently opens news diagnostic ways by the identification of early markers of this risk and could later on ollow to develop therapeutic, pharmacological or nutritionalways
Soto, Sônia de Fátima. "Alterações placentárias em resposta à exposição de ratas Wistar à poluição atmosférica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-20052015-081635/.
Повний текст джерелаIntroduction: Exposure to air pollution during pregnancy causes alterations in placental characteristics and may result in intrauterine growth restriction. It was suggested that transforming growth factor beta 1 (TGFbeta1), the uteroplacental renin-angiotensin system (RAS) and angiogenic factors, such as vascular endothelial growth factor A (VEGF-A) participates of the placentation process and regulation of the uteroplacental blood flow. Thus, the aim of the present study was to investigate the effect of exposure to air pollution on the placental morphology, function and placental RAS. Methods: Female Wistar rats were exposed to filtrated air (F) or to concentrated particulate matter 2.5um (P) for 15 days. After mating, rats were divided in 4 groups and again exposed to F or P (FF, FP, PF, PP). At 19th day of pregnancy, maternal and fetal portions of placenta were collected. Placental structure, TGFbeta1, VEGF-A and its receptors and RAS components were evaluated. Results: Exposure to particulate matter decreased placental mass, size and surface area, an indicative of maternal-fetal interaction. Placental TGFbeta1, RAS components and VEGF-A and receptors Flk-1 concentrations were altered and this may indicate a prejudice in the trophoblast invasion, placental angiogenesis and maternal-fetal nutrients and gases exchange. Discussion: These findings indicate that exposure to particulate matter compromises the maternal-fetal interaction and may reflect on fetal nutrition and growth
Haapsamo, M. (Mervi). "Low-dose aspirin therapy in IVF and ICSI patients." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514296208.
Повний текст джерелаTiivistelmä Keinoalkuisten hedelmöityshoitojen seurauksena keskimäärin reilu kolmannes naisista tulee raskaaksi hoitokertaa kohti. Näissä raskauksissa äidin seerumista määritettyjen istukkaperäisten merkkiaineiden pitoisuuksissa on eroavaisuuksia verrattuna spontaanisti raskaaksi tulleiden naisten seerumipitoisuuksiin ensimmäisen ja toisen raskauskolmanneksen aikana. Pre-eklampsian eli raskausmyrkytyksen riski on myös lisääntynyt. Syyksi arvellaan istukan verisuonipuuston poikkeavaa kehitystä. Pre-eklampsiaan liitetään intravaskulaarisen prostasykliinin ja tromboksaanin epätasapaino, joka johtaa verihiutaleiden aggregaation lisääntymiseen ja verisuonten supistumiseen. Matala-annoksinen asetyylisalisyylihappo (ASA) vähentää tromboksaanituotantoa ja korjaa tromboksaani- ja prostasykliinituotannon epätasapainoa, mutta sen ei ole todettu merkittävästi vähentävän näiden raskauskomplikaatioiden esiintyvyyttä edes riskiryhmillä, kun lääkitys on aloitettu toisen raskauskolmanneksen aikana. Tämän satunnaistetun ja plasebo-kontrolloidun kaksoissokkotutkimuksen tavoitteena oli tutkia keinoalkuisia hedelmöityshoitoja saavilla naisilla matala-annoksisen ASA-hoidon (100 mg/vrk) merkitystä munasarjojen stimulaatiovasteeseen, alkion kiinnittymiseen, istukan muodostumiseen ja kehittymiseen sekä lääkehoidon vaikutusta kohdun, istukan ja sikiön verenkiertoon, kun lääkitys aloitettiin munasarjojen stimulaatiohoidon alkaessa. Lisätavoitteena oli selvittää, onko lapsettomuushoitoja saavien naisten raskauksissa todettavissa spesifinen istukkaproteomiikkalöydös (istukan tuottamat valkuaisaineet) verrattuna spontaanisti raskaaksi tulleisiin naisiin ja voidaanko siihen vaikuttaa matala-annoksisella ASA-hoidolla. Toisena lisätavoitteena oli selvittää matala-annoksisen ASA-hoidon vaikutus pre-eklampsian esiintyvyyteen loppuraskaudessa. Matala-annoksinen asetyylisalisyylihappo (ASA) ei paranna keinoalkuisten hedelmöityshoitojen hoitotuloksia eikä vaikuta kohdun verenkiertoon tai kohdun limakalvon paksuuteen ultraäänellä arvioituna alkion siirtopäivänä. Matala-annoksista ASA-hoitoa käyttäneiden potilaiden ryhmässä todettiin kuitenkin merkitsevästi vähemmän naisia, joilla oli huonoa hoitotulosta keinoalkuisissa hedelmöityshoidoissa ennakoiva korkea molemminpuolinen kohtuvaltimoiden verenvirtausvastus alkion siirtopäivänä verrattuna plasebo-ryhmään. Raskaaksi tulleilla naisilla, jotka käyttivät matala-annoksista ASA-hoitoa, todettiin kohdun verenvirtausvastus matalammaksi alku- ja keskiraskaudessa verrattuna plasebo-ryhmän naisiin. Istukkaproteomiikkatutkimusten mukaan varhaisistukan proteiinituotanto on erilainen keinoalkuisissa raskauksissa verrattuna spontaanisti alkaneisiin raskauksiin ja siihen voidaan vaikuttaa matala-annoksisella ASA-hoidolla. Pre-eklampsian ja sikiön kasvunhidastuman esiintyvyydessä ei ryhmien välillä todettu eroa. Matala-annoksinen ASA-hoito aloitettuna ennen raskautta munasarjojen stimulaatiohoidon alkaessa ei paranna munasarjojen vastetta lapsettomuushoidoissa käytettäville hormonihoidoille, raskauslukuja eikä kohdun verenkiertoa alkion siirtopäivänä. Hoidon todettiin kuitenkin vaikuttavan varhaisistukan kehittymiseen sekä parantavan kohdun verenkierto alku- ja keskiraskaudessa viitaten istukan verisuonipuuston parempaan kehittymiseen. Matala-annoksinen ASA-hoito ei vähentänyt istukkaperäisten raskauskomplikaatioiden esiintymistä
Alvarenga, Cláudia Maria Domingues. "Avaliação dos mecanismos de ação interceptiva e/ou embriotóxica do extrato aquoso de Plectranthus barbatus Andr.(bolbo-brasileiro) administrado a ratas prenhez no período de pré-implantação /." Botucatu : [s.n.], 2006. http://hdl.handle.net/11449/104597.
Повний текст джерелаBanca: João Lauro Viana de Camargo
Banca: Márcia Guimarães da Silva
Banca: Silvana Lima Górniak
Banca: Regiane Kawakami
Tese não possui um resumo geral, possue um resumo para cada capítulo
Resumo : O objetivo do presente estudo foi verificar, experimentalmente, o possível mecanismo pelo qual o extrato aquoso de Plectranthus barbatus (boldo-brasileiro), planta utilizada popularmente como abortiva, atua sobre o organismo materno ou sobre o desenvolvimento do concepto durante o período de pré-implantação, correlacionando sua ingestão com possíveis alterações no transporte e desenvolvimento embrionário ou com alterações hormonais maternas...(Resumo completo, clicar acesso eletrônico abaixo)
Abstract : The present study was conducted to determine the possible mechanism by which the aqueous extract of Plectranthus barbatus (brazilian-boldo), a plant used popularly as abortive agent, can lead to early loss of pregnancy, correlating this possible effect with morphological alterations in the embryo, oviductal motility dysfunctions or maternal hormonal level modifications...(Complete abstract, access undermentioned electronic address)
Doutor
Alvarenga, Cláudia Maria Domingues [UNESP]. "Avaliação dos mecanismos de ação interceptiva e/ou embriotóxica do extrato aquoso de Plectranthus barbatus Andr.(bolbo-brasileiro) administrado a ratas prenhez no período de pré-implantação." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/104597.
Повний текст джерелаCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O objetivo do presente estudo foi verificar, experimentalmente, o possível mecanismo pelo qual o extrato aquoso de Plectranthus barbatus (boldo-brasileiro), planta utilizada popularmente como abortiva, atua sobre o organismo materno ou sobre o desenvolvimento do concepto durante o período de pré-implantação, correlacionando sua ingestão com possíveis alterações no transporte e desenvolvimento embrionário ou com alterações hormonais maternas...
The present study was conducted to determine the possible mechanism by which the aqueous extract of Plectranthus barbatus (brazilian-boldo), a plant used popularly as abortive agent, can lead to early loss of pregnancy, correlating this possible effect with morphological alterations in the embryo, oviductal motility dysfunctions or maternal hormonal level modifications...(Complete abstract, access undermentioned electronic address)
Bobé, Pierre. "La gestation : un modele d'etude de la regulation de la reponse immunitaire." Paris 7, 1987. http://www.theses.fr/1987PA077192.
Повний текст джерела"Longitudinal multimodal imaging of in vivo placental function during the onset of preeclampsia and in response to therapeutic intervention in the reduced uterine perfusion pressure rat." Tulane University, 2021.
Знайти повний текст джерелаPreeclampsia is a leading cause of maternal and fetal mortality, affecting up to 8% of pregnancies. Clinically, preeclampsia is diagnosed by the new onset of maternal hypertension and proteinuria presenting in the second half of gestation. The etiology of this disease, however, occurs during early development with abnormal vascular remodeling that results in reduced placental perfusion and hypoxia. This abnormal placental function increases the production of soluble antiangiogenic factors which are then released into maternal circulation, creating the systemic endothelial dysfunction associated with maternal symptoms. Despite being a critical indicator of disease progression and therapeutic response, placental function cannot be fully characterized by existing imaging modalities. The objective of this work was to develop multimodal imaging and image processing tools characterize placental function in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia. We demonstrate spectral photoacoustic (sPA) imaging and contrast-enhanced ultrasound (CEUS) imaging of the longitudinal changes in placental oxygenation, perfusion, and vascular growth in the development of preeclampsia and evaluate the placental response to therapeutic intervention.
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Dylan J Lawrence
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Повний текст джерелаThesis (Master, Anatomy & Cell Biology) -- Queen's University, 2011-08-01 14:29:12.489
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Повний текст джерелаThesis (Ph.D.)-University of KwaZulu-Natal, Westville, 2011.
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Повний текст джерелаThesis (Master, Anatomy & Cell Biology) -- Queen's University, 2013-07-05 14:37:05.15