Дисертації з теми "Raman SERS spectroscopy"
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Sharma, Narayan. "Solution Processable Surface Enhanced Raman Spectroscopy (SERS) Substrate." Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1434375587.
Повний текст джерелаFarazkhorasani, Fatemeh. "Raman and SERS studies of filamentous fungi." Royal Society of Chemistry, 2012. http://hdl.handle.net/1993/23855.
Повний текст джерелаOctober 2014
Gühlke, Marina. "Oberflächenverstärkte Hyper-Raman-Streuung (SEHRS) und oberflächenverstärkte Raman-Streuung (SERS) für analytische Anwendungen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17570.
Повний текст джерелаHyper-Raman scattering follows different symmetry selection rules than Raman scattering and, as a non-linear two-photon process, profits even more than Raman scattering from enhanced electromagnetic fields at the surface of plasmonic nanostructures. Surface-enhanced hyper-Raman scattering (SEHRS) could thus gain practical importance for spectroscopy. The combination of SEHRS and surface-enhanced Raman scattering (SERS) offers complementary structural information. Specifically, due to the localization of the enhancement to the close proximity of the nanostructures, this information can be utilized for the characterization of the interaction between molecules and metal surfaces. The aim of this work was to increase the understanding of the SEHRS effect and to assess its applicability to answer analytical questions. For that purpose, SEHRS experiments with excitation at 1064 nm and SERS experiments with excitation at the same wavelength, as well as with excitation at 532 nm - to detect SEHRS and SERS in the same spectral region - were conducted. As an example for non-resonant excitation, pH-dependent SEHRS and SERS spectra of para-mercaptobenzoic acid were examined. Based on these spectra, the interaction of different silver nanostructures with the molecules was characterized. beta-Carotene was used to study the influence of resonance enhancement by the excitation of a molecular electronic transition during SEHRS experiments. By the thiol-functionalization of carotene, a more intense interaction with the silver surface was achieved, which enables to obtain not only resonant SEHRS and SERS but also non-resonant SERS spectra of carotene. Hyperspectral SEHRS imaging in combination with microspectroscopy was demonstrated by analyzing the distribution of different dyes on structured plasmonic surfaces.
Boddu, Naresh Kumar. "Trace analysis of biological compounds by surface enhanced Raman scattering (SERS) spectroscopy /." Connect to resource online, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1229542206.
Повний текст джерелаChowdhury, Mustafa Habib. "The use of Surface Enhanced Raman Spectroscopy (SERS) for biomedical applications." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4816.
Повний текст джерелаNoonan, Jonathan. "Surfaced enhanced Raman spectroscopy (SERS) for the molecular imaging of atherosclerosis." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8939/.
Повний текст джерелаMarotta, Nicole Ella. "Patterned nanoarray sers substrates for pathogen detection." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37274.
Повний текст джерелаGant, Virgil Alexander. "Detection of integrins using surface enhanced raman spectroscopy." Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969.1/2304.
Повний текст джерелаOchsenkühn, Michael Andreas. "Modern Raman spectroscopy for investigation of host-pathogen interactions." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4760.
Повний текст джерелаSirimuthu, Narayana M. S. "Increasing the range and reproducibility of quantitative surface-enhanced Raman spectroscopy (SERS)." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431477.
Повний текст джерелаBoddu, Naresh K. "Trace Analysis of Biological Compounds by Surface Enhanced Raman Scattering (SERS) Spectroscopy." Youngstown State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1229542206.
Повний текст джерелаDe, Jesus Jenny Padua. "HEAVY METAL DETECTION IN AQUEOUS ENVIRONMENTS USING SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS)." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1513185193940902.
Повний текст джерелаCarneiro, Leandro de Bispo. "Detecção do peptídeo p17 (HIV) baseado em SERS (Surface-enhanced Raman Spectroscopy) /." Araraquara, 2015. http://hdl.handle.net/11449/138424.
Повний текст джерелаBanca: Marcelo Nalin
Banca: Antonio Aparecido Pupim Ferreira
Banca: Gustavo Fernandes Souza Andrade
Banca: Airton Abrahan Martin
Resumo: A espectroscopia de Raman intensificada por superfície (SERS, termo em inglês Surfaceenhanced Raman Spectroscopy) é uma técnica promissora que mostra a sensibilidade para a detecção da interação de biomoléculas que são importantes para detecção precoce de doenças. O vírus da imunodeficiência humana (HIV) têm sido um grande problema por várias décadas. Existem vários métodos de deteção baseados na interação específica de anticorpos, tais como, o ELISA e os testes rápidos (TR's). No entanto, novas estratégias têm sido desenvolvidas para rápido diagnóstico do vírus HIV, e uma prova de conceito de detecção do peptídeo p17-1 foi descrito neste trabalho. A proteina matriz p17 é uma essencial proteína no ciclo de replicação do vírus HIV. As fases iniciais da replicação do vírus envolve a pré integração do complexo do DNA no núcleo do p17 desempenhando um papel na ligação de RNA viral e transporte para a membrana. Neste trabalho foram descritos duas plataformas SERS para a detecção do vírus HIV baseado no peptide p17 -1 (sequência LSGGELDRWEKIRLPGG). O anticorpo foi imobilizado em um substrato de ouro usando duas diferentes camadas automontadas (SAM). A primeira SAM, os substratos de ouro foram imersos em uma solução aquosa de 11 mercaptoundecanóico (MUA). Na segunda SAM, os substratos foram imersos em uma mistura aquosa de politietileno glicol (SHPEG- COOH e SH-PEG-CH3). Aqui serão chamados de SAM-MUA e SAM-PEG, respectivamente. Ambas as SAM's foram imersas emu ma solução de anticorpo (anti-p17) e foram descritas como plataforma d captura MUA e PEG. Ambas plataformas foram funcionalizadas com o peptídeo p17-1. Sondas SERS foram preparadas com nanopartículas de ouro e revestidas com uma molécula Raman reporter (azul de Nilo A) e funcionalizadas com um anticorpo anti-p17. Estas estruturas (sonda SERS e plataformas de captura) formam um ensaio sanduíche...
Abstract: Surface-enhanced Raman Scattering (SERS) technique offers great promises for simplified and sensitive detection of biomolecular interactions that are relevant for early disease diagnostics. Human immunodeficiency virus (HIV) has been a problem for decades. There are several methods of diagnostics based on antibodies specific reactions, such as enzyme-linked immunosorbent assays (ELISAs) and rapid test (RT). However, new strategies have been developed for rapid HIV diagnostics and, as a proof-of-concept, peptide p17-1 was considered here. The matrix protein p17 is a structural protein that is essential in the life cycle of the retrovirus The early stages of the virus replication involve the pre integration of the DNA complex into the nucleus P17 plays a role in RNA viral binding and transport to the membrane. Here were describe two new SERS platform for HIV detection based on peptide p17-1 (sequence LSGGELDRWEKIRLPGG). The antibody anti-p17 was immobilized in a planar gold surface using two differents self-assembled (SAM) techniques. First SAM, were obtained by immersion of the surface into ethanolic solution of 11-Mercaptoundecanoic acid (MUA). Second SAM were obtained by immersion in aqueous solution aquous mixtures of (SH-PEG-COOH/SH-PEG-CH3) and polyethylene glycol (PEG,). Here were describe the two platforms as SAM-MUA and SAMPEG, respectively. Both SAM's were immersed in a solution containing the anti-p17. Samples at this step were called capture platform-MUA and capture platform-PEG. Both capture platforms were funcionalizated with the peptide p17-1. SERS probes were prepared with gold nanoparticles coated with a Raman reporter molecule (Nile Blue A) and, functionalized with an anti-p17. These structures (SERS probe and capture platforms) allow for a sandwich assay, a strategy regularly used for high-sensitivity detection. The light blue color in the SERS mapping represents peptide strong...
Doutor
Ray, Bryan Hubert. "SERS analysis of biological analytes using an azo tether." Laramie, Wyo. : University of Wyoming, 2005. http://proquest.umi.com/pqdweb?did=1095427621&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.
Повний текст джерелаTsoutsi, Dionysia. "Inorganic Ions Sensing by surface-enhanced Raman scattering spectroscopy." Doctoral thesis, Universitat Rovira i Virgili, 2015. http://hdl.handle.net/10803/288213.
Повний текст джерелаEn este proyecto de tesis se ha conseguido desarrollar un sistema de detección, identificación y cuantificación independiente de iones inorgánicos. La detección de los iones se basa en su diferente afinidad hacia diferentes ligandos orgánicos a través de la espectroscopia de dispersión Raman aumentada por superficies (surface-enhanced Raman scattering, SERS). En resumen, como sustrato se utilizarán nanopartículas de plata o microesferas nanoestructuradas que se prepararán mediante la adsorción de nanopartículas de oro sobre la superficie de microesferas de sílice mediante el protocolo de capa por capa y su posterior crecimiento epitaxial con plata. Este último paso se realizará mediante protocolos desarrollados en nuestro laboratorio y tiene como objetivo la obtención de superficies plasmónicas discretas altamente eficientes en SERS. Los sustratos se funcionalizarán posteriormente con ligandos orgánicos tiolados con alta afinidad por iones inorgánicos (el fluoróforo orgánico, amino-MQAE y la terpiridina, pztpy-DTC). Como paso siguiente, se realizará la detección y cuantificación simultánea de los iones combinando para su detección espectroscopia SERS. Los cambios espectrales SERS en el modo de vibración de los ligandos orgánicos están correlacionados como función de la concentración de cada ion con límites de detección comparables a los de varios métodos analíticos convencionales.
In this research project we successfully developed a novel sensing system for the identification and quantification of inorganic ions independently by means of surface-enhanced Raman scattering (SERS) spectroscopy. The detection of the ions is based on their different affinity toward various organic ligands. In summary, we use as SERS-active substrates, either silver nanoparticles or composite nanostructured particles prepared by adsorption of gold nanoparticles on the surface of silica microbeads, using layer-by-layer assembly protocol and the subsequent epitaxial overgrowth of silver. This last step is performed using protocols developed in our laboratory and aims to the fabrication of highly plasmonic surfaces for SERS experiments. Next, the substrates are functionalized with thiolated organic ligands with high affinity toward inorganic ions (amino-MQAE, an organic fluorophore, and pztpy-DTC, a terpyridine). As a further step, the simultaneous identification and quantification of the ions, using SERS spectroscopy, is performed. Vibrational changes in the SERS spectra of the organic ligands are correlated as a function of the concentration of each ion with limits of detection comparable to those of several conventional analytical methods.
Halvorson, Rebecca Ann. "Raman Spectroscopy for Monitoring of Microcystins in Water." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/76924.
Повний текст джерелаMaster of Science
Zhou, Yan. "Synthesis, Characterization and Application of SERS-active Metal Nanoparticles." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1458644099.
Повний текст джерелаCarella, Yvonne. "Development of SERS for the determination of environmental pollutants." Thesis, University of Strathclyde, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288745.
Повний текст джерелаSant\'Ana, Antonio Carlos. "Caracterização da 2,2\':6\',2\" - terpiridina adsorvida sobre superfície de prata, através da técnica SERS (Surface Enhanced Raman Spectroscopy)." Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/46/46132/tde-16102007-110432/.
Повний текст джерелаSelf-assembly monolayers of 2,2\':6\',2\" - terpyridine (tpy) were grown on Ag and Cu electrode surface and studied ex situ and in situ by SERS (Surface Enhanced Raman Spectroscopy). The nature of the adsorbate species was studied as a function of the mother-sulution changing solvent, pH and supporting-anion. The effect of 2-mercaptopyrimidine (mpy) as co-adsorbate was also investigated. For comparison purposes the Raman spectrum of tpy was obtained as solid, solution, molten and as Ag+ and CU2+ complexes. A supplementary Raman study of CU2+ perchlorates was also performed to facilitate the understanding of the Cl04- adsorption on the metal surface. The results showed that tpy adsorb on the metallic surface through the nitrogen atoms forming two different surface complexes (type I and type II) that have cis-cis conformation. Protonated tpy, preferentially, loses the proton to adsorb on the electrode. In the in situ experiments, when more negative potentials were applied, the observed spectral changes were ascribed to a modification in the adsorption geometry leading to a nearly flat arrangement. In presence of mpy, tpy adsorbs flat on the electrode surface and coordination with the metal is not observed. Studies on the adsorption of the 4\'-(5-mercaptopentyl)-2,2\':6\',2\"-terpyridine (tpy-SH) on Ag electrode showed that the molecule adsorb through the sulfur atom and there is no interaction between the nitrogen atoms of tpy moiety and the metal. This was confirmed by coordination of CU2+ with the tpy moiety of adsorbed tpy-SH molecules and by the enhancement of the alkyl-thiol bands which are close to the surface. Studies of the [Cu(II)tpyH2OCl04]Cl04 complex showed that depending on the energy density used the exciting radiation may cause the release of the coordinated water, leading to a bidentate coordination of the Cl04- anion. The Raman excitation profile for this complex was obtained and pre-resonance enhancement associated with a transition between 300 e 350 nm was observed. When adsorbed on the electrode surface this complex undergoes reduction and the tpy coordinates to the metal atoms forming a surface complex.
Touzalin, Thomas. "Tip-enhanced Raman spectroscopy on electrochemical systems." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS364.
Повний текст джерелаThe in situ investigation of electrochemical interfaces structures at the nanoscale is a key element in the understanding of charge and electron transfer mechanisms e.g. in the fields of energy storage or electrocatalysis. This thesis introduces the implementation of tip-enhanced Raman spectroscopy (TERS) in liquid and in electrochemical conditions enabling the nanoscale analysis of electrified solid/liquid interfaces through the strong and local electric field enhancement at gold or silver scanning tunneling microscopy (STM) probes. The ability of TERS to image inhomogeneities in the coverage density of a self-assembled monolayer (SAM) through a layer of organic solvent on gold was demonstrated. A TERS-inspired analytical tool was also developed, based on a TERS tip used simultaneously as a single-hot spot surface-enhanced Raman spectroscopy (SERS) platform and as a microelectrode (EC tip SERS). The reduction of an electroactive SAM could then be monitored by electrochemical and in situ SERS measurements. In situ electrochemical STM-TERS was also evidenced through the imaging of local variations of the electric field enhancement on peculiar sites of a gold electrode with a lateral resolution lower than 8 nm. Finally TERS also demonstrated to be efficient in investigating the structure of organic layers grafted either by electrochemical reduction or spontaneously. This work is therefore a major advance for the analysis of functionalized surfaces
Yang, Mingwei. "In Situ Arsenic Speciation using Surface-enhanced Raman Spectroscopy." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3387.
Повний текст джерелаSACCO, ALESSIO. "Metrological Approach to Tip-enhanced Raman Spectroscopy." Doctoral thesis, Politecnico di Torino, 2020. http://hdl.handle.net/11583/2827709.
Повний текст джерелаLin, Sally S. B. Massachusetts Institute of Technology. "Investigation into the use of surface-enhanced Raman spectroscopy (SERS) for organic dye analysis." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98657.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (pages 48-49).
In art conservation, color is essential to understanding a society's culture and history-as an indicator of beauty, status, religion, and more-but has a tendency to fade and diminish over time. Analytical techniques, particularly that of pigment identification, can reveal the artifact's original color and appearance and give new insights to an artist's intentions, techniques, date of creation, and more. However, most identification procedures are invasive and destroy the samples in the process. Surface-enhanced Raman spectroscopy (SERS) has recently been identified as a technique that is minimally invasive and also solves the issue of fluorescence that is found in many other techniques. In this paper, a specific SERS procedure has been developed for the identification of yellow organic dyes from 18th century Japanese Woodblock prints. Several SERS spectra of nine dyes both in solution and applied on artist paper have also been documented in hopes of assisting with pigment identification in the future.
by Sally Lin.
S.B.
Madden, Odile Marguerite, and Odile Marguerite Madden. "Development of Vapor Sensors for Volatile Museum Contaminants by Surface Enhanced Raman Spectroscopy (SERS)." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/283712.
Повний текст джерелаMabbott, Samuel. "Optimisation of solid-state and solution-based SERS systems for use in the detection of analytes of chemical and biological significance." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/optimisation-of-solidstate-and-solutionbased-sers-systems-for-use-in-the-detection-of-analytes-of-chemical-and-biological-significance(de70094c-8da0-4326-bfb2-6adf00b86af9).html.
Повний текст джерелаSaffie, Jared C. "Microfluidic evaporator chip for concentration of bacterial samples for SERS identification." Thesis, Boston University, 2014. https://hdl.handle.net/2144/21248.
Повний текст джерелаSepsis is a serious medical condition in which a person becomes infected with bacteria in his or her bloodstream. The symptoms of sepsis are a result of the immune system’s interaction with the infecting agent. Currently, to diagnose a patient with sepsis, a blood sample must be collected and cultured for 24-48 hours before the infection can be confirmed. In the meantime, a broad-scope antibiotic is administered which may or may not be effective in treating the patient. If the antibiotic is ineffective, a different antibiotic must be chosen. When the results of the blood culture are available, a narrow scope antibiotic, appropriate to treat the infection is administered. However, sepsis has a mortality rate of 18-30% depending on the infecting agent and the treatment is highly time sensitive. Within 24 hours, the syndrome may progress to septic shock and mortality rates reach 50%. Therefore, it is important to quickly and correctly identify the infecting agent and provide immediate targeted treatment. Surface Enhanced Raman Spectroscopy (SERS) can be used to quickly identify and distinguish between different bacterial strains; however it requires higher bacterial concentrations than are present in the blood during the early stages of sepsis. A microfluidic evaporator chip has been developed to concentrate bacteria samples from 4μl to 100nl; the chip has been evaluated for concentration efficiency on Escherichia coli and methicillin-sensitive Staphylococcus aureus. Various blocking methods using bovine serum albumin (BSA) have been tested to reduce bacterial adhesion to the chip and have improved bacterial recovery to around 70% for both strains tested. Ongoing tests are being performed to improve bacterial recovery and sample purity for identification.
2031-01-01
Hugall, James T. "On the nature of SERS from plasmonic nanostructures." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/267496.
Повний текст джерелаMuralidharan, Ranjani. "Investigation and characterization of Pt-modified Au catalysts and polymer composites by electrochemistry, Raman and surface enhanced Raman spectroscopy (SERS)." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5084.
Повний текст джерелаOhlhaver, Christopher M. "Use of Surface Enhanced Raman Spectroscopy for the Detection of Bioactive Lipids." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5551.
Повний текст джерелаReymond-Laruinaz, Sébastien. "Biomolécules et systèmes nanostructurés : caractérisation par spectrométrie Raman exaltée de surface (SERS)." Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOS023/document.
Повний текст джерелаThis work addressed the study of several kinds of nanostructured systems, biomolecules and inorganic thin films, mainly by Surface Enhanced Raman Spectroscopy (SERS). The aim was to investigate the structure and the chemical bonds. Transmission electron microscopy (TEM) was also used to complete the structural characterization of the different samples.Firstly, the study was conducted on molecules of biological interest. The aim was to study the interaction between silver nanoparticles and proteins. With this aim, silver nanoparticles bioconjugated with different proteins (hemoglobin, cytochrome C, BSA and lysozim) were synthesized. SERS results allowed concluding that proteins are chemisorbed on the silver nanoparticules surface. SERS was also used in the low frequency range to characterize the structure of thin deposits of caffeine, a molecule of pharmaceutical interest.Raman spectroscopy and SERS were also used to study nanostructured TiO2:Au thin films. The first stages of the growth of gold nanoparticles in Au doped TiO2 thin films under annealing treatments were studied by low frequency Raman spectroscopy and TEM. Finally, it was shown that SERS effect can be used for the characterization of ultra-thin TiO2 films. With this aim, ultra-thin TiO2 films were deposited by Atomic Layer Deposition on Si substrates functionalized with gold nanoparticles and studied by SERS
Beffara, Flavien. "SERS biosensors based on special optical fibers for clinical diagnosis." Thesis, Limoges, 2021. http://www.theses.fr/2021LIMO0009.
Повний текст джерелаDespite important breakthroughs in biosensing, we are still in need of new sensors that would facilitate the early detection of severe diseases such as cancer. Classical tissue biopsy remains the gold standard in many cases. Although this approach has shown its potential, it remains invasive for the patients and the detection techniques are either tedious or lack the sensitivity to detect the disease at an early stage. Raman spectroscopy has demonstrated its interests for biosensing. Its ability to characterize the chemical nature, structure and the orientation of an analyte makes it an ideal candidate. The sharp Raman peaks of a molecule can be seen as a true fingerprint. Regrettably, Raman scattered signal is extremely weak. This limitation was overcome by surface enhanced Raman spectroscopy (SERS), since it drastically increases the Raman scattered signal while maintaining the sharp peak of the fingerprint spectrum of a molecule. Unfortunately, most of the current SERS substrates are 2D nano-roughened metal surfaces or colloidal nanoparticles, which lack the sensitivity and reliability in measurement with poor repeatability and reproducibility in the data. In the recent years, special optical fibers have been used as SERS platforms. They feature holes that run along their entire length. These holes allow for the analyte to be incorporated inside the fiber. Thus, such platform represents a promising alternative to planar substrates since the analyte and the excitation light can interact for longer length inside the fibers. In addition, optical fibers are very flexible, compact and allow for low-loss light guiding. Therefore, such fiber sensors exhibit the outstanding detection abilities of SERS, the advantages of optical fibers and improved sensitivity and reliability. In this manuscript, we aim to create a biosensing platform that could be routinely used in a clinical setting. For that, we propose to optimize the features of an already reported fiber topology. This allows us to increase its sensitivity while simultaneously improving its reliability and practicability. With this improved sensor, for the first time, we could detect the biomarker for ovarian cancer in clinical cyst fluids, which allowed us to differentiate the stage of the cancer. Subsequently, we propose a novel fiber topology, specifically designed to further increase the sensitivity of SERS-based fiber probes. This is achieved by increasing the surface of interaction compared to standard fiber sensors. For that, the core diameter is significantly increased and the amount of light that interacts with the analyte is precisely controlled. We envision that such functionalized fiber sensors could be incorporated inside a biopsy needle to create a two-in-one sensor for body fluid collection and readout that can eventually overcome the limitations associated with existing biopsy needle platforms, which demands for two-step sample collection and readout
Costa, Jean Claudio Santos. "Desenvolvimento de sensores nanoestruturados para análises químicas por meio de técnicas espectroscópicas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-02052013-090958/.
Повний текст джерелаThe use of spectroscopic techniques to the study of environmental issues is an area of research that has been experiencing major development in recent times. The sensitivity and selectivity characteristics of surface-enhanced Raman scattering (SERS) suggest that this technique can be very useful for the study of complex samples, such as those related to the investigation of pollutants in the environment. The focus of this thesis is dedicated to the development of methodologies for the use of the SERS effect to the spectroscopic study of different classes of chemical species of environmental interest. The construction of high-performance substrates for SERS is investigated aiming for their use as analytical sensors, identification, quantification and study of aspects related to the reactivity of polycyclic aromatic hydrocarbons (PAH), organophosphorus compounds, organochlorine compounds and triazinic compounds. Among the investigated substrates, we mention colloidal gold and silver nanoparticles of different shapes (nanorods, nanocubes, nanowires and bimetallic particles) and gold and silver nanoparticles immobilized on polymeric films. We seek to establish correlations between morphology and chemical composition of nanostructures and adsorption mechanisms of the investigated molecules on the metal substrates. We use DFT calculations (Density Functional Theory) to simulate possible adsorbate-nanoparticle interactions, allowing a better understanding of the processes of chemical interaction between the metal nanostructures and the substances of interest.
Gorunmez, Zohre. "Finite-Difference Time-Domain (FDTD) Modeling of Nanoscale Plasmonic Substrates for Surface-Enhanced Raman Spectroscopy (SERS)." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563296001850111.
Повний текст джерелаCARA, ELEONORA. "Tailored fabrication of nanostructured substrates for surface-enhanced Raman spectroscopy applications." Doctoral thesis, Politecnico di Torino, 2019. http://hdl.handle.net/11583/2735516.
Повний текст джерелаHong, Seongmin. "Optimization, Modification and Application of Gold Nanoparticles as the Substrates of Surface Enhanced Raman Spectroscopy." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4819.
Повний текст джерелаLahr, Rebecca Halvorson. "Advanced Applications of Raman Spectroscopy for Environmental Analyses." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/54010.
Повний текст джерелаPh. D.
Weber, Verena. "Plasmonic nanostructures for the realization of sensor based on surface enhanced Raman spectroscopy." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423838.
Повний текст джерелаLa Plasmonica si occupa dell’interazione di una radiazione elettromagnetica di opportuna lunghezza d’onda con gli elettroni di conduzione di un metallo. L’oscillazione collettiva degli elettroni, indotta da questa interazione, è chiamata appunto Risonanza Plasmonica. La risonanza plasmonica di superficie localizzata avviene quando gli elettroni coinvolti sono quelli di superficie di un metallo nanostrutturato con dimensioni minori o comparabili alla lunghezza d’onda di eccitazione. Da questa eccitazione deriva una forte amplificazione del campo elettromagnetico locale, localizzato nelle immediate vicinanze della nanostruttura metallica. Tale amplificazione, unita a una tecnica di rivelazione spettroscopica specifica, quale la spettroscopia Raman, può essere sfruttata per la realizzazione di sensori molecolari. La tecnica Raman è conosciuta come altamente specifica, perché in grado di fornire uno spettro caratteristico della singola molecola, identificandone univocamente la presenza e la costituzione. La sua maggiore limitazione, però, è la bassa sensibilità. Ponendo l’analita in prossimità di un substrato plasmonico, proprio nella regione di forte amplificazione del campo locale, la sensibilità di rivelazione viene fortemente aumentata, dando origine alla spettroscopia Raman amplificata da superfici (SERS). La prima parte del presente lavoro è focalizzata sulla sintesi e sulla caratterizzazione di nanoparticelle d’argento, d’oro e di nano gusci d’oro (chiamati nanoshell) e sul loro impiego per la realizzazione di substrati SERS, sia in soluzione colloidale che su substrato solido. L’utilizzo di differenti nanostrutture metalliche, dà la possibilità di sfruttare la risonanza plasmonica localizzata di superficie in un’ampia regione spettrale, che si estende dal visibile al vicino infrarosso. La caratterizzazione ottica e morfologica delle nanostrutture è stata effettuata con tecniche convenzionali, come la spettroscopia di assorbimento UV-visibile, il SERS, la microscopia elettronica a trasmissione e la microscopia a forza atomica. Ad esse è stata affiancata anche una tecnica raramente usata nell’ambito della plasmonica: la spettroscopia fotoacustica. Questa può fornire informazioni riguardanti il contributo di assorbimento, all’estinzione totale, di una nanostruttura plasmonica. Da una rigorosa misura dei fattori di amplificazione e delle proprietà di fotoacustica al variare della lunghezza d’onda, possono essere fatte alcune considerazioni riguardanti la possibile relazione tra l’estinzione (proprietà di campo lontano) e l’ amplificazione SERS (proprietà di campo vicino). Le misure dei profili di eccitazione SERS su substrati plasmonici in liquido e su supporto solido, hanno evidenziato la presenza di hot spots, ovvero di zone fortemente amplificate dall’interazione di due o più nanostrutture. I substrati SERS solidi sono risultati chimicamente stabili, omogenei e riproducibili; essi presentano valori di fattori di amplificazione attorno a 104-105. In soluzione colloidale, i fattori di amplificazione delle nanostrutture hanno raggiunto valori nell’intervallo 103-106, dipendentemente dal tipo di nanostruttura metallica investigata. Le misure di fotoacustica effettuate su soluzioni colloidali di nanoshell d’oro si sono rivelate in accordo con le predizioni teoriche di letteratura. Nella seconda parte del lavoro, i substrati plasmonici, realizzati principalmente con nanoparticelle e nanoshell d’oro, sono stati impiegati per la realizzazione di sensori SERS per la rivelazione di specie chimiche e biologiche. É stato realizzato un sensore di composti tossici aromatici volatili, accoppiando un substrato plasmonico con un film poroso di sol gel ibrido organico-inorganico. La componente organica della matrice sol gel è stata appositamente scelta per la sua alta affinità a composti aromatici, quali lo Xilene. È stata dimostrata l’amplificazione dei segnali della matrice da parte della componente plasmonica, ma si sono riscontrati alcuni problemi nella rivelazione delle molecole di analita attraverso il SERS. La difficoltà nella rivelazione è probabilmente dovuta al veloce deadsorbimento dello Xilene dalla matrice a causa del forte riscaldamento locale causato dalla radiazione laser. Nonostante questo, si è comunque dimostrata l’aumentata efficienza del sensore progettato, rispetto ai suoi componenti singoli. La seconda applicazione studiata ha riguardato la realizzazione di un sistema analita-accettore innovativo, che può essere utilizzato per diverse applicazioni bioanalitiche; esso è basato sull’interazione tra un cromoforo diazobenzenico (HABA) e il suo anticorpo specifico. Alla base dell’applicazione si trova una proprietà interessante del suddetto cromoforo, che è quella di cambiare la sua struttura molecolare, passando da una forma azo alla forma idrazo, dopo aver interagito con il suo anticorpo specifico. Questa variazione nella struttura molecolare può essere sfruttata per la rivelazione dell’avvenuta interazione analita-accettore, mediante SERS. Alcuni derivati di questo cromoforo sono stati sintetizzati e caratterizzati in modo da poter essere adsorbiti su un substrato SERS, che viene successivamente incubato in una soluzione di anticorpo. I segnali SERS della molecola di HABA sono risultati ben visibili sia sui substrati di nanoparticelle che di nanoshell d’oro. Purtroppo non è stato possibile rivelare la variazione strutturale del cromoforo, in quanto gli anticorpi, estratti in vivo da due coniglietti, inducono solo un parziale cambio di struttura, rendendo la rivelazione SERS alquanto difficile.
Levene, Clare. "Advanced Raman, SERS, and ROA studies of biomedical and pharmaceutical compounds in solution." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/advanced-raman-sers-and-roa-studies-of-biomedical-and-pharmaceutical-compounds-in-solution(1c05f618-b1c2-4663-870a-3d51b32dad7b).html.
Повний текст джерелаHughes, Juanita Maree. "A novel identification method for ultra trace detection of biomolecules using functionalised Surface Enhanced Raman Spectroscopy (SERS)." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/72864/2/Juanita_Hughes_Thesis.pdf.
Повний текст джерелаZeng, Jianbo. "Gold Nanoshells: Synthesis and Applications to In Situ SERS." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1362843561.
Повний текст джерелаCordeiro, Denise de Sales. "Estudo do comportamento químico de desreguladores endócrinos utilizando o efeito SERS e processos fotoquímicos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-04092012-102703/.
Повний текст джерелаAn environmental issue of concern is contamination of the environment by substances which interact with the endocrine systems of humans and animals. Such substances are called endocrine disruptors (ED) and, like other environmental pollutants, may produce adverse effects in human health. In this work, we explore the application of vibrational spectroscopy and electrochemical techniques in the study of ED, in terms of their detection, characterization, study of their reactivity, development of methods for their photochemical degradation, study of the involved mechanisms and characteristic of degradation products. The approach employs the use of advanced spectroscopic techniques, with special attention for the development of methodology of surface-enhanced vibrational spectroscopy, associated or not with electrochemical systems. Among the compounds thought to cause endocrine disruption, the present study is dedicated to the photochemical and electrochemical study of the following substances: the plasticizer bisphenol A (BPA), the triazinic pesticides ametrine and atrazine, and the organochlorine compounds 2,4-dichlorophenoxyacetic acid and 2,4-dichlorophenol. The study of photolytic and TiO2-mediated photocatalytic degradation was carried out for BPA and ametrine. Such processes are important for the removal of such substances from the environment. The photocatalytic studies were extended to include the use of TiO2-Pr composite as catalysts. The doping of TiO2 by the rare earth ion praseodymium results in changes in the physicochemical properties of semiconducting material, being a valuable method for enhancing the photocatalytic activity of TiO2. Our results showed the need of percentage control of the chemical modification for the optimization of the photocatalytic process, with the 1% praseodymium/titanium ration the optimal composition. The study of photolysis and TiO2-mediated photocatalytic degradation processes of BPA shows significant differences between the degradation and mineralization, suggesting the production of recalcitrant organic compounds. For ametrine, photolysis and photocatalytic degradation processes were found to occur via different mechanisms. Spectroelectrochemical studies of endocrine disruptors (ED) were carried out through surface-enhanced Raman spectroscopy (SERS effect) aiming at the understanding of the nature of the chemical interaction between these molecules and nanostructured metallic surfaces, and at the vibrational characterization of the products formed by faradaic charge transfer processes. Products of oxidation and reduction chemical reactions were identified through spectral changes observed in the SERS spectra as a function of cathodic and anodic potentials.
Israelsen, Nathan. "Surface-Enhanced Raman Spectroscopy-Based Biomarker Detection for B-Cell Malignancies." DigitalCommons@USU, 2015. https://digitalcommons.usu.edu/etd/4605.
Повний текст джерелаDoctor, Erika L. "Development of a Surface-Enhanced Raman Spectroscopy Method for the Detection of Benzodiazepines in Urine." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1642.
Повний текст джерелаCorio, Paola. "A contribuição do mecanismo de transferência de carga para o efeito SERS em interfaces eletroquímicas." Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/46/46132/tde-03072009-114359/.
Повний текст джерелаIn this work, attention has been given to systems in which the charge transfer (CT) mechanism is contributing to the enhancement of the Raman scattering of species adsorbed on metal surfaces in order to address the participation of a resonance Raman effect on this part of the total enhancement. A model for the adsorbate-metal surface interaction and the charge transfer mechanism for surface-enhanced Raman scattering (SERS) is presented. The fundamental observation behind the currently proposed model is that ali previous theories indicate that Raman intensity should be at maximum when the incident laser frequency is resonant with a surface/adsorbate charge transfer band. This fact leads to the conclusion that this aspect of the chemical effect may be due to a resonance Raman mechanism. Therefore, for such mechanism to be valid, the chemical effect of SERS must follow the already well established principies of resonance Raman theory. In this model, the metal surface provides a source of electrons that may, upon interaction with light, flow into and out of the adsorbed species. Based on this model we have proposed a formalism derived from the time-domain description of the resonance Raman effect that describes the dependence of the SERS intensities of molecules adsorbed in electrochemical interfaces upon the applied potential. This approach accounts for the enhancement of totally symmetric modes via a Franck-Condon mechanism, and only one electronic excited state of the adsorbate/surface system is considered. The analytical expression derived to calculate the SERS intensity versus applied potential profiles and their dependence on the exciting radiation has been applied for pyridine and for the ion complex [Fe2(CN)10bpy]6- adsorbed on a silver electrode. A good agreement between calculated and experimental excitation profiles have been obtained for both investigated species. Resonance Raman spectroscopy is also an electronic spectroscopy, and, as presented in this work, the SERS effect, or part of it, is also an electronic spectroscopy. Its intensity contains, therefore, information about the structure of the excited electronic state involved in the charge transfer process. This information is provided by the calculation of the SERS excitation profiles according to the derived expression in the form of ΔK values. The remaining sections of this work are dedicated to the study of the SERS effect of coordination compounds adsorbed on silver electrodes. One of the investigated systems is the mixed ligand ion complex [Ru(bpy)2viol]+. The SERS measurements have shown that the vibrational modes of both ligands can be selectively enhanced by changing the electrochemical applied potential at a fixed laser excitation energy. This result indicates the presence of two different metal to adsorbate photon assisted charge transfer processes. The first one involves a density of donor states near the Fermi level (EF) of the metal and na acceptor state localized on the violurate ligand, while the second process involves na acceptor state localized on the bpy ligand. These results demonstrate the possibility of reaching different excited electronic states of molecules adsorbed on electrode surfaces, selectively enhancing different chromofores by changing the applied potential and of assigning electronic charge transfer transitions based on SERS results. In order to provide a more detailed description of the charge transfer mechanism of enhancement working in the SERS effect of adsorbed molecules, including the role of multiple excited electronic states, vibronic coupling and symmetry selection rules, the SERS effect of iron phthalocyanine is discussed. The charge transfer mechanism of enhancement in this system is characterized as a potential modulated charge transfer process involving two donor states at the FePc and an acceptor state at the silver electrode surface. Excitation of the SERS spectra at wavelengths off resonance with the Q-band may enhance the a2g vibrational modes (non allowed modes at normal Raman condition), via a Herzberg-Teller mechanism, providing that the applied potential is dose to the resonance condition for the adsorbate to metal charge transfer transition. The effects of the chemical nature of the solvent in the adsorption geometry and in the position of the electronic states of adsorbates is discussed for the cyano complexes Fe(phen)2(CN)2 and [Fe2(BPE)(CN)10]6-. The results obtained have demonstrated the decisive role played by the chemical nature of solvents and supporting electrolytes in the surface-enhanced spectroscopy of species adsorbed at electrochemical interfaces. In fact, the nature of solvent or electrolyte - molecule interaction can determine the bonding to the surface, and therefore, selective enhancement of vibrational modes within a molecule can be accomplished. Based on the charge transfer processes between the surface and the adsorbed molecules probed by the SERS excitation profiles, it has been possible, in some cases, to determine the position of the energy levels of the adsorbate in relation to the Fermi level of the metal electrode.
Kwon, Yong-Hyok [Verfasser], and Heinz-Detlef [Akademischer Betreuer] Kronfeldt. "Surface-Enhanced Raman Scattering (SERS) Surfaces for in-situ trace analysis of PAHs in water by Shifted Excitation Raman Difference Spectroscopy (SERDS) / Yong-Hyok Kwon. Betreuer: Heinz-Detlef Kronfeldt." Berlin : Universitätsbibliothek der Technischen Universität Berlin, 2012. http://d-nb.info/1021976393/34.
Повний текст джерелаMarsich, Lucia. "Design and synthesis of functionalized metal nanoparticles for bio-analysis with surface-enhanced Raman scattering (SERS)." Doctoral thesis, Università degli studi di Trieste, 2013. http://hdl.handle.net/10077/8580.
Повний текст джерелаThe objective of this doctoral research is the development and the implementation of SERS-active substrates with biological samples. The substrates consist in coated silver nanoparticles synthesized by chemical reduction of a silver salt. The biological samples are the anionic chromophore bilirubin and two heme protein, the cationic cytochrome-c and the anionic protein cytochrome b5. In the first part of this work, positively charged nanoparticles were prepared by coating citrate-reduced silver nanoparticles with the cationic polymer poly-L-lysine and were employed with bilirubin in the experiments listed below: detection of nanomolar bilirubin concentrations in aqueous solutions, showing that the SERS intensity increases linearly with concentration in a range from 10 nM to 200 nM, allowing quantitative analysis of bilirubin aqueous solutions. indirect quantification of bilirubin cellular up-take, demonstrating the ability to detect the bilirubin also in a buffer solution suitable for cell growth with pH 7.4. Since the bilirubin quantification at this pH is no longer possible, the poly-L-lysine was substituted by two polymers with a quaternary nitrogen atom. bilirubin measurement in serum, but TEM images highlights the formation of a albumin layer around the nanoparticles, blocking the interaction between bilirubin and the nanoparticles. Hence the citrate-reduced silver nanoparticles were coated with an hydrophobic capping and re-dispersed in hexane, to avoid the albumin layer around the nanoparticles. In the second part of this doctoral thesis, silver nanoparticles were prepared via seed growth method and subsequently coated with chitosan or silica in order to obtain positively or negatively charged nanoparticles respectively. Such substrates enhance the spectrum of the cytochrome-c and cytochrome-b5 on polished silver electrode without directly interact with the protein. Thanks to the presence of chitosan or silica coated nanoparticles, the cytochrome-c and cytochrome-b5 can be detected on a gold substrate.
L’obiettivo di questo dottorato è lo sviluppo e l’implementazione di substrati SERS attivi con campioni biologici. Nanoparticelle di argento ricoperte sono state scelte come substrati. I campioni biologici analizzati sono la bilirubina e due proteine eme, il citocromo-c (cationico) e il citocromo-b5 (anionico). Nella prima parte di questo lavoro le nanoparticelle di argento sono state preparate usando come agente riducente il citrato e successivamente sono state ricoperte con un polimero cationico, la poli-lisina. Le nanoparticelle cariche positivamente così ottenute sono state impiegate con la bilirubina nei seguenti esperimenti: rilevazione di concentrazioni nano-molari di bilirubina in soluzioni acquose, dimostrando che per concentrazioni comprese tra 10 e 200 nM, l’intensità degli spettri SERS aumenta linearmente con la concentrazione. È quindi possibile l’analisi quantitativa di bilirubina in soluzioni acquose. quantificazione indiretta dell’assorbimento cellulare di bilirubina, documentando la possibilità di rilevare la bilirubina in una soluzione tampone che permetta la crescita cellulare a pH 7.4. Dal momento che la quantificazione della bilirubina in questa soluzione buffer non è più possibile, la poli-lisina è stata sostituita con due polimeri che presentano un azoto quaternario. misura della bilirubina nel siero, ma le immagini TEM evidenziano la formazione intorno alle nanoparticelle di uno strato di albumina, che impedisce l’interazione della bilirubina con le nanoparticelle ricoperte di poli-lisina. Per evitare la formazione dello strato di albumina, le nanoparticelle di argento sono state quindi ricoperte con un capping idrofobico e ridisperse in esano. Nella seconda parte di questa tesi di dottorato, le nanoparticelle di argento sono state preparate a partire da nanoparticelle di qualche nanometro e successivamente ricoperte con chitosano o silice. Lo spettro del citocromo-c e del citocromo-b5 sono stati amplificati grazie alla presenza di queste nanoparticelle senza interagire direttamente con le proteine. Grazie alla presenza delle nanoparticelle ricoperte di chitosano o silice, il citocromo-c e il citocromo-b5 sono stati misurati su un substrato d’oro.
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Petroni, Cintia Regina. "Síntese e funcionalização de nanopartículas de ouro utilizando um modelo de substância húmica comercial." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-05082013-154550/.
Повний текст джерелаOrganic dyes are an important class on environmental pollutants, and the nature of the interaction of such species with humic acid strongly determines their environmental behavior and fate. This work investigates different approaches for the synthesis of humic acid-gold nanoparticles (HA-AuNP), the performance of these particles as sensors for trace determination of organic dyes and the nature of their chemical interaction with humic acids by surface-enhanced Raman scattering (SERS). The Au nanoparticles were obtained by direct fabrication in aqueous media.The synthesis were carried out in the presence of humic acid at various pH values, and in the presence and absence of sodium citrate. In this approach, humic acid serves different purposes. In the synthesis of the nanoparticles, they serve as reducing agent and for surface stabilization, preventing coalescence of the nanoparticles in aqueous media. Considering the use of the nanoparticles as SERSactive substrates, the humic acid serves as an extraction phase associated with the SERS platform, favoring the interaction of the organic dyes with the metallic nanoparticles. This approach can be used to enhance the sensitivity and selectivity of SERS technique and avoid interference from other species in solution. It is also important to mention that the humic acid gives rise to a very weak Raman spectrum, and therefore does not interfere significantly in the spectroscopic detection of the species of interest. The obtained HA-AuNPs were characterized by electronic spectroscopy, scanning electron microscopy and SERS, in order to establish a correlation between their morphology, surface plasmon, and their potential use as SERS platforms. The HA-AuNPs have been applied as SERS substrates for anionic and cationic textile dyes. The recorded Raman spectra are, in these cases, assigned to the complex formed by the humic acid and each of the species of interest. The obtained results revealed a significant dependence on the morphological and electronic properties of the HA-AuNPs with the synthesis procedure, and also a strong interaction between the nanoparticles and cationic dies. We conclude that HA-AuNP may provide a valuable approach for the spectroscopic characterization of environmentally relevant species and their chemical interaction with humic acids, through the use of surface enhanced Raman spectroscopy
Dridi, Hamida. "Méthodologies pour la réalisation d'un substrat SERS à base de silicium poreux pour la détection de molécules chimiques et biologiques." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1S012/document.
Повний текст джерелаThe work of this thesis focuses on the realization of SERS substrates (Surface Enhanced Raman Scattering) for the detection of chemical and biological species. This is to implement the methodologies using as the starting surface of a porous silicon layer and a surface Plasmon effect induced by the presence of a noble metal in general. The specificities of the porous layers which are firstly a nanometer roughness and secondly a porosity and therefore an inner surface have a direct impact on the target molecule detection sensitivity. We have developed in this PhD thesis different substrates development methodologies SERS-based on porous silicon layers. We considered two ways, the first is based on the use of gold nanoparticles in colloidal solution. The second route, more original, uses the deposition of gold by sputtering on a porous layer prepared on the rough side of a silicon wafer. Interesting SERS results regarding the detection of chemical (Rhodamine 6G) and biological (Bovin Serum Albumin) molecules, have been described and explained for considering various solutions to optimize them
Baker, Joshua Dale. "Near Single-Molecule SERS-Based Detection Using Ultrafiltered, Unfunctionalized Silver Nanoparticles." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1344523437.
Повний текст джерелаAlam, Md Khorshed. "Fabrication of surface enhanced Raman spectroscopy (SERS) active substrates based on vertically aligned nitrogen doped carbon nanotube forest." Thesis, Umeå universitet, Institutionen för fysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101573.
Повний текст джерела