Дисертації з теми "Radiotherapy"
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Jain, Pooja. "Optimising Radiotherapy for Cancers affected by Respiratory Motion using Image Guided Radiotherapy." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492923.
Повний текст джерелаPINZI, VALENTINA. "Immuno-Radiotherapy for brain glioma: sorting out the immunomodulatory effects of radiotherapy." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/402376.
Повний текст джерелаBACKGROUND. Glioblastoma (GBM) is a fast-growing and aggressive brain tumor. GBM is the most frequent malignant primary brain tumour and it can result in death in three-six months, if untreated. The current standard of care (SOC) therapy consists in maximal safe surgical resection followed by radiation therapy and adjuvant temozolomide (Stupp protocol), with a median overall survival (OS) of 8-10 months. However, more than half of GBM patients die within one year from the diagnosis, and only 5% survive more than 5 years despite aggressive therapies. Research has now shifted additional attention to methods of modulating the innate immune system for the treatment of GBM. Moreover, radiotherapy, that plays a key role in GBM treatment, has the potential to convert immunologically ‘cold’ tumors into ‘hot’ tumors by a combination of distinct mechanisms. Overall, literature data indicate that local radiation produces systemic, immune-mediated anti¬tumour and, potentially, antimetastatic effects. Additionally, the combination of local radiotherapy and immune-modulation can augment local tumour control and cause distant (abscopal) antitumour effects through increased tumour-antigen release and antigen-presenting cell (APC) cross-presentation, improved dendritic-cell (DC) function, and enhanced T cell priming. In order to sort out the immunomodulatory effects of radiotherapy for brain glioma we conducted this project, also in association with immunetherapy. The radiological response has been evaluated as well. METHODS. Radiotherapy treatment in combination with dendritic cell immunotherapy was evaluated. GL261-glioma bearing immune-competent mice were treated by means of RT (3 fractions, 1 fr/day) as exclusive and concomitant immunotherapy (dendritic cells). Two clinical trials were studied as well. The population was GBM patients treated by means of standard therapy plus DC-vaccine therapy. Response assessment of GBM after radio-chemotherapy and during immunotherapy by delayed contrast trams (treatment response assessment maps) was evaluated as well. RESULTS. Survival, CD8+ T, NK cells were significantly and slightly significant different: control vs RT vs RT-IT. We found that activated microglia persists in both tumor and contralateral brain of irradiated mice. Moreover, RT promoted antitumoral M1 polarization and RT contributed to a massive recruitment of Th1 CD4+ T cells; RT and DC combination contributes to a robust infiltrate of CD8+ T cells. CONCLUSION. Our results confirm that RT can modulate the TME creating a specific chemokine gradient involved in T cell homing. RT in combination with IT can induce an anti-tumour systemic long-lasting effector CD8+ T cell response as well as a local infiltration of NK cells and CD8+ T cells. The combinatorial approach seems to be a promising therapy for GBM patients. It might be evaluated trough other clinical trials in order to confirm the preliminary results.
Mairs, Robert J. "Targeted radiotherapy of cancer." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248190.
Повний текст джерелаMillin, Anthony. "Verification of stereotactic radiotherapy." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/12287/.
Повний текст джерелаEdwards, Craig Richard. "In-vivo radiotherapy dosimetry." Thesis, Keele University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269237.
Повний текст джерелаHelo, Y. "Cerenkov emission in radiotherapy." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1469478/.
Повний текст джерелаAllahverdi, Mahmoud. "Accuracy in radiotherapy dosimetry." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/21135.
Повний текст джерелаCecconi, Agnese <1979>. "Stereotactict body radiotherapy (SBRT)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4317/1/Cecconi_Agnese_tesi.pdf.
Повний текст джерелаCecconi, Agnese <1979>. "Stereotactict body radiotherapy (SBRT)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4317/.
Повний текст джерелаTaylor, Alexandra. "Intensity-modulated radiotherapy for cervical cancer : optimising target volume definition and radiotherapy delivery." Thesis, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510901.
Повний текст джерелаMurphy, Caroline Claire Scanlon. "A history of radiotherapy to 1950 : cancer and radiotherapy in Britain 1850-1950." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278710.
Повний текст джерелаSteenbakkers, Roel Johannes Henricus Marinus. "Optimizing target definition for radiotherapy." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/40825.
Повний текст джерелаCufflin, Rebecca Sian. "Verification of Intensity Modulated Radiotherapy." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/25873/.
Повний текст джерелаMcMahon, S. J. "Heavy Atom Radiotherapy Dose Enhancement." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527871.
Повний текст джерелаLewis, R. D. "Monte Carlo modelling for radiotherapy." Thesis, Swansea University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637892.
Повний текст джерелаJohnson, Kerstie Anne. "Predicting radiotherapy toxicity in patients treated with radical radiotherapy using predictive assays and circadian rhythm." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/40982.
Повний текст джерелаBär, Werner. "Optimized delivery of intensity modulated radiotherapy." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965610934.
Повний текст джерелаRadu, Calin. "Optimising Radiotherapy in Rectal Cancer Patients." Doctoral thesis, Uppsala universitet, Enheten för onkologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172531.
Повний текст джерелаRojas, Callejas Ana Maria. "ARCON in experimental and clinical radiotherapy." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-207.
Повний текст джерелаMartling, Anna. "Rectal cancer : staging, radiotherapy and surgery /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-461-5/.
Повний текст джерелаLanglands, Fiona Elizabeth. "Sensitivity to radiotherapy in breast cancer." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582111.
Повний текст джерелаYin, Zaizhe. "Solid state detectors in radiotherapy dosimetry." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288576.
Повний текст джерелаGulliford, Sarah Louise. "Artificial neural networks applied to radiotherapy." Thesis, Institute of Cancer Research (University Of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404474.
Повний текст джерелаGrellet, Sophie. "Optimisation of gold nanoparticles for radiotherapy." Thesis, Open University, 2018. http://oro.open.ac.uk/57326/.
Повний текст джерелаAhbabi, Salma Saeed Al. "Achievable accuracy and reproducibility in radiotherapy." Thesis, University of Surrey, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616955.
Повний текст джерелаTaylor, Carolyn W. "Breast cancer radiotherapy and heart disease." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:c9dda3ca-8cb3-4a38-938d-0b75b4f6471d.
Повний текст джерелаCheng, Kun. "Deformable models for adaptive radiotherapy planning." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22893.
Повний текст джерелаSandberg, Linnea. "Quality assurance of a radiotherapy registry." Thesis, Umeå universitet, Institutionen för fysik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176779.
Повний текст джерелаLeite, Rocha Pedro. "Novel approaches to radiotherapy treatment scheduling." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12281/.
Повний текст джерелаHowarth, Ashley L., Joshua R. Niska, Kenneth Brooks, Aman Anand, Martin Bues, Carlos E. Vargas, and Raman C. Mahabir. "Tissue Expanders and Proton Beam Radiotherapy." LIPPINCOTT WILLIAMS & WILKINS, 2017. http://hdl.handle.net/10150/625389.
Повний текст джерелаElmpt, Wouter Johannes Catharina van. "3D dose verification for advanced radiotherapy." Maastricht : Maastricht : Universitaire Pers ; University Library, Universiteit Maastricht [host], 2009. http://arno.unimaas.nl/show.cgi?fid=14960.
Повний текст джерелаNyholm, Tufve. "Verification of dose calculations in radiotherapy." Doctoral thesis, Umeå : Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1931.
Повний текст джерелаVaras, Jaime Armando. "Spectral unfolding of radiotherapy photon beams." Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28131.
Повний текст джерелаCanada, Justin M. "Impaired Cardiorespiratory Fitness Following Thoracic Radiotherapy." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5499.
Повний текст джерелаJayasekera, Piyakeerthi Mangala. "Practical aspects of radiotherapy gel dosimetry." Thesis, Queensland University of Technology, 2000.
Знайти повний текст джерелаSmith, Shaun T. "Development of gel dosimetry for radiotherapy." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/102759/1/Shaun_Smith_Thesis.pdf.
Повний текст джерелаMorrey, D. "Aspects of computer automation in radiotherapy : A system for prescription, calculation, verification and recording of radiotherapy treatments." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376420.
Повний текст джерелаBurnet, Neil Gunn. "The relationship between cellular radiation sensitivity and normal tissue response to radiotherapy : prospects for individualising radiotherapy prescriptions." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357208.
Повний текст джерелаJena, Rajesh. "Optimisation of radiotherapy for patients with high-grade glioma using diffusion tensor imaging and intensity modulated radiotherapy." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614124.
Повний текст джерелаLewis, Benjamin C. "Radiotherapy Response Using Intravoxel Incoherent Motion Magnetic Resonance Imaging in Liver Patients Treated with Stereotactic Body Radiotherapy." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5821.
Повний текст джерелаLin, Lan. "Development and clinical application of an integrated treatment planning platform for 4D radiotherapy : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1400966621&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.
Повний текст джерелаOlofsson, Jörgen. "Developing and evaluating dose calculation models for verification of advanced radiotherapy /." Umeå : Strålningsvetenskaper Radiation Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-841.
Повний текст джерелаGozbasi, Halil Ozan. "Optimization approaches for planning external beam radiotherapy." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34726.
Повний текст джерелаRiekki, R. (Riitta). "Late dermal effects of breast cancer radiotherapy." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514282760.
Повний текст джерелаGilbert, L. "Improving the safety of radiotherapy treatment delivery." Thesis, Coventry University, 2015. http://curve.coventry.ac.uk/open/items/58d00757-edad-48c5-8676-9f5bf07ffd7c/1.
Повний текст джерелаWyer, J. A. "Radiolysis of Molecules of Interest in Radiotherapy." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492265.
Повний текст джерелаGreer, Peter Brian. "A dual assembly multileaf collimator for radiotherapy." Title page, table of contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phg81659.pdf.
Повний текст джерелаMoerland, Marinus Adriaan. "Magnetic resonance imaging in radiotherapy treatment planning." [S.l.] : Utrecht : [s.n.] ; Universiteitsbibliotheek Utrecht [Host], 1996. http://www.library.uu.nl/digiarchief/dip/diss/01760825/inhoud.htm.
Повний текст джерелаBelderbos, Josepha Sophia Antonia. "Radiotherapy in lung cancer: a moving field." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/45315.
Повний текст джерелаCurtin-Savard, Arthur. "Dose delivery uncertainty in photon beam radiotherapy." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22856.
Повний текст джерелаWe have measured the degree of precision which exists in our institution by examining each step of the radiotherapy process on a cobalt unit and a 10 MV linear accelerator. Our study finds beam intensity uncertainties of $ pm$3.8% (one standard deviation) and beam positional uncertainties of $ pm$5.5 mm (one standard deviation). The effect of these uncertainties on the dose to the patient is illustrated for a typical case.