Готові списки джерел за темами / Radiation-induced fibrosi

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Добірка наукової літератури з теми "Radiation-induced fibrosi"

Автор: Grafiati
Опубліковано: 11 березня 2023

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Статті в журналах з теми "Radiation-induced fibrosi"

1

Borrelli, Mimi R., Abra H. Shen, Gordon K. Lee, Arash Momeni, Michael T. Longaker, and Derrick C. Wan. "Radiation-Induced Skin Fibrosis." Annals of Plastic Surgery 83 (October 2019): S59—S64. http://dx.doi.org/10.1097/sap.0000000000002098.

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2

Kim, Jin-Mo, Hyun Yoo, Jee-Youn Kim, Sang Ho Oh, Jeong Wook Kang, Byung Rok Yoo, Song Yee Han, et al. "Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3." Cellular Physiology and Biochemistry 48, no. 3 (2018): 959–70. http://dx.doi.org/10.1159/000491964.

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Background/Aims: Radiation-induced skin fibrosis is a common side effect of clinical radiotherapy. Our previous next-generation sequencing (NGS) study demonstrated the reduced expression of the regulatory α subunit of phosphatidylinositol 3-kinase (PIK3r1) in irradiated murine skin. Metformin has been reported to target the PIK3-FOXO3 pathway. In this study, we investigated the effects of metformin on radiation-induced skin fibrosis. Methods: Metformin was orally administered to irradiated mice. Skin fibrosis was analyzed by staining with H&E and Masson’s trichrome stain. The levels of cytokines and chemokines associated with fibrosis were analyzed by immunohistochemistry and quantitative RT-PCR. The roles of PIK3rl and FOXO3 in radiation-induced skin fibrosis were studied by overexpressing PIK3rl and transfecting FOXO3 siRNA in NIH3T3 cells and mouse-derived dermal fibroblasts (MDF). Results: The oral administration of metformin significantly reduced radiation-induced skin thickening and collagen accumulation and significantly reduced the radiation-induced expression of FOXO3 in murine skin. Additionally, the overexpression of PIK3r1 reduced the radiation-induced expression of FOXO3, while FOXO3 silencing decreased the radiation-induced expression of TGFβ in vitro. Conclusions: The results indicated that metformin suppresses radiation-induced skin injuries by modulating the expression of FOXO3 through PIK3r1. Collectively, the data obtained in this study suggested that metformin could be a potent therapeutic agent for alleviating radiation-induced skin fibrosis.
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3

Topuzov, E. E., T. T. Agishev, K. A. Fedorov, D. A. Krasnozhon, A. B. Vats, D. V. Romanovsky, G. A. Dashyan, et al. "Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer." HERALD of North-Western State Medical University named after I.I. Mechnikov 10, no. 2 (December 15, 2018): 58–63. http://dx.doi.org/10.17816/mechnikov201810258-63.

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Late radiation injury in the form of radiation-induced fibrosis is one of the many complications of radiation therapy.In current literature, pathogenesis of radiation-induced fibrosis is considered from several angles. According to one of the hypotheses, the main cause of pathogenesis of radiation-induced fibrosis is damage of the blood vessels caused by radiation. Another hypothesis insists that radiation causes depletion of specific cell populations in the irradiated area, reducing the number of stem cells (mostly, fibroblasts). (For citation: Topuzov EE, Agishev TT, Fedorov КА, et al. Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer. Herald of North-Western State Medical University named after I.I. Mechnikov. 2018;10(2):58-63. doi: 10.17816/mechnikov201810258-63).
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4

Weigel, C., P. Schmezer, C. Plass, and O. Popanda. "Epigenetics in radiation-induced fibrosis." Oncogene 34, no. 17 (June 9, 2014): 2145–55. http://dx.doi.org/10.1038/onc.2014.145.

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5

Xavier, Sandhya, Ester Piek, Makiko Fujii, Delphine Javelaud, Alain Mauviel, Kathy C. Flanders, Ayelet M. Samuni, et al. "Amelioration of Radiation-induced Fibrosis." Journal of Biological Chemistry 279, no. 15 (January 19, 2004): 15167–76. http://dx.doi.org/10.1074/jbc.m309798200.

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6

Hoeller, Ulrike, Michael Bonacker, Amira Bajrovic, Winfried Alberti, and Gustav Adam. "Radiation-Induced Plexopathy and Fibrosis." Strahlentherapie und Onkologie 180, no. 10 (October 2004): 650–54. http://dx.doi.org/10.1007/s00066-004-1240-3.

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7

Blakaj, A., X. Chi, W. F. Mourad, E. Herzog, L. Leng, and R. Bucala. "Metallothioneins in Fibrosis: Implications for Radiation-Induced Fibrosis." International Journal of Radiation Oncology*Biology*Physics 90, no. 1 (September 2014): S684—S685. http://dx.doi.org/10.1016/j.ijrobp.2014.05.2011.

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8

Liu, Chun-Shan, Reka Toth, Ali Bakr, Ashish Goyal, Md Saiful Islam, Kersten Breuer, Anand Mayakonda, et al. "Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response." Cancers 13, no. 10 (May 18, 2021): 2455. http://dx.doi.org/10.3390/cancers13102455.

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Radiotherapy, a common component in cancer treatment, can induce adverse effects including fibrosis in co-irradiated tissues. We previously showed that differential DNA methylation at an enhancer of diacylglycerol kinase alpha (DGKA) in normal dermal fibroblasts is associated with radiation-induced fibrosis. After irradiation, the transcription factor EGR1 is induced and binds to the hypomethylated enhancer, leading to increased DGKA and pro-fibrotic marker expression. We now modulated this DGKA induction by targeted epigenomic and genomic editing of the DGKA enhancer and administering epigenetic drugs. Targeted DNA demethylation of the DGKA enhancer in HEK293T cells resulted in enrichment of enhancer-related histone activation marks and radiation-induced DGKA expression. Mutations of the EGR1-binding motifs decreased radiation-induced DGKA expression in BJ fibroblasts and caused dysregulation of multiple fibrosis-related pathways. EZH2 inhibitors (GSK126, EPZ6438) did not change radiation-induced DGKA increase. Bromodomain inhibitors (CBP30, JQ1) suppressed radiation-induced DGKA and pro-fibrotic marker expression. Similar drug effects were observed in donor-derived fibroblasts with low DNA methylation. Overall, epigenomic manipulation of DGKA expression may offer novel options for a personalized treatment to prevent or attenuate radiotherapy-induced fibrosis.
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Horton, Jason A., Fei Li, Eun Joo Chung, Kathryn Hudak, Ayla White, Kristopher Krausz, Frank Gonzalez, and Deborah Citrin. "Quercetin Inhibits Radiation-Induced Skin Fibrosis." Radiation Research 180, no. 2 (July 2, 2013): 205. http://dx.doi.org/10.1667/rr3237.1.

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10

Rosenbloom, Joel. "Therapeutic Approaches to Radiation-Induced Fibrosis." Journal of Cancer Treatment and Diagnosis 2, no. 4 (August 1, 2018): 7–9. http://dx.doi.org/10.29245/2578-2967/2018/4.1144.

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Більше джерел

Дисертації з теми "Radiation-induced fibrosi"

1

Meziani, Lydia. "Study of Interaction Between the Inflammatory Response and Radiation-Induced Fibrosis." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T041.

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La fibrose radio-induite (FRI) est une complication tardive de la radiothérapie souvent associée à une réponse inflammatoire chronique et à un infiltrat de macrophages. Aujourd’hui, les macrophages sont pressentis comme des médiateurs cellulaires important dans le processus de fibrose mais leur rôle n’a jamais été étudié dans le contexte de la FRI. Dans une précédente étude nous avions montré que l’irradiation (IR) induit une polarisation M1 des macrophages cardiaques après irradiation de souris ApoE-/- et est associée un score de fibrose élevé, ce qui suggérait que la polarisation des macrophages pourrait contribuer à la fibrogénèse radio-induite. Afin de valider cette hypothèse, nous avons cherché à caractériser le rôle des macrophages dans la FRI en utilisant un modèle classique de fibrose pulmonaire chez la souris C57Bl/6 induit après IR thoracique à 16Gy. Nous avons caractérisé les phénotypes et la fonction des macrophages alvéolaires (MA) et interstitiels (MI). Durant la phase précoce, les résultats montrent une déplétion des MA accompagnée de la sécrétion de CXCL1, MCP-1 et de MCSF. Cette déplétion est suivie d’une repopulation suite au recrutement et à la prolifération des monocytes/macrophages d’origine médullaire. La nouvelle population de MA présente une polarisation hybride accompagnée d’une augmentation simultanée de la sécrétion de cytokines Th1 et Th2. Durant la phase tardive les MI présentent une polarisation de type M2 accompagnée d’une diminution des cytokines Th1 et d’une augmentation de cytokines Th2 dans le lysat tissulaire. Nous avons ensuite cherché à caractériser la contribution des MA hybrides vs MI M2 dans le processus de fibrose. Nous avons montré que contrairement au MA hybrides, les MI M2 étaient capables d’induire l’activation des fibroblastes in vitro et l’expression de TGF-β1. De plus, la déplétion des MA hybrides avec une administration intranasale de clodronate exacerbe la FRI et induit l’augmentation de l’infiltrat de MI M2. Ensuite, nous nous somme interrogés à la contribution du processus de fibrose dans la polarisation des macrophages. Après 24h de coculture entre fibroblastes irradiés et macrophages pulmonaires non irradiés, une sécrétion de cytokines telles que M-CSF et TIMP-1 qui pourraient stimuler l’activation des fibroblastes est observée. De plus, l’inhibition de la FRI avec de la pravastatine montre que l’inhibition de la fibrose est accompagnée d’une augmentation des MI M1 et d’une diminution des MI M2 dans le poumon. En résumé, nos résultats montrent une contribution opposée des Macrophages Alvéolaires et des Macrophages Interstitiels dans le processus de fibrose radio-induite ainsi qu’une contribution du processus de fibrose dans le type d’activation des Macrophages interstitiels formant ainsi une boucle d’activation fibrogénique chronique
Radiation-induced fibrosis (RIF) is a delayed complication of radiotherapy often associated with chronic inflammatory process and macrophage infiltration. Nowadays, macrophages are suggested to be important cellular contributors to fibrogenic process, but their implication in the context of RIF has never been investigated. In a previous study we have shown that irradiation (IR) induced the polarization of cardiac macrophages into M1 in ApoE-/- mice and was associated with a high fibrosis score in ApoE-/- mice, suggesting that macrophage polarization could drive tissue sensitivity to ionizing radiation. This observation prompted us to investigate the role of macrophages in RIF using a classical experimental model of lung fibrosis developed in C57Bl/6 mice after 16Gy thorax-IR. We profiled both alveolar macrophages (AM) and interstitial macrophages (IM). During the acute phase we found AM depletion associated with CXCL1, MCP-1 and M-CSF secretion, followed by a repopulation phase mediated by recruitment and proliferation of monocytes/macrophages from the bone marrow. Interestingly, the newly recruited AM exhibited a yet never described hybrid polarization (M1/M2), associated with the up-regulation of both Th1 and Th2 cytokines. At delayed times points, IM were M2-polarized and associated with downregulation of Th1 cytokines and upregulation of Th2 cytokines in tissue lysates. These results suggest a differential contribution of hybrid AM vs M2 IM to fibrogenesis. Interestingly, in contrast to activated hybrid AM, activated M2 IM were able to induce fibroblast activation in vitro mediated by an enhanced TGF-β1 expression. Therefore, specific depletion of hybrid AM using intranasal administration of clodrosome increased RIF score and enhanced M2 IM infiltration. We next evaluated if the fibrogenic process can in turn affect macrophage polarization. Interestingly, after coculture of irradiated fibroblast with non-irradiated pulmonary macrophages, secretion of cytokines such as M-CSF and TIMP-1, which can stimulate macrophage activation, was observed. Furthermore, RIF inhibition using pravastatin treatment showed that fibrosis inhibition was associated with a decrease in M2 IM accompanied by an increase in M1 IM, but had no effect on polarization of AM. These present study shows a dual and opposite contribution of alevolar versus intertitial macrophages in RIF and the contribution of the fibrogenic process to IM polarization, resulting thereby in a chronical fibrogenic loop
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2

Hamama, Saad. "Radiation-induced fibrosis : Characterization of the anti-fibrotic mechanisms displayed by pentoxifylline/vitamin E." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T071.

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La fibrose radio-induite est une complication sévère et tardive de la radiothérapie. Plusieurs études cliniques ont montré que la combinaison pentoxifylline-vitamine E est un traitement sûr et efficace contre la fibrose. Cependant, les mécanismes moléculaires de son efficacité restent inexplorés. Nous avons montré l’efficacité de la combinaison pentoxifylline-vitamine E dans l’entéropathie radique dans une faisabilité clinique. En parallèle, en utilisant un modèle unique, in vitro, de cellules musculaires lisses intestinales primaires isolées des personnes atteintes de l’entéropathie radique, nous avons montré une synergie entre la pentoxifylline et l’analogue hydrophile de vitamine E (trolox) qui permet à l’association d’inhiber l’expression de TGF-β1 au niveau de l’ARN messager et de la protéine. Cette action inhibitrice intervient au niveau transcriptionnel et conduit à une inhibition conséquente des cibles de la voie de signalisation TGF-β1/Smad (Col Iα1, FN1, PAI-1, CTGF), alors qu’elle semble sans effet sur la voie de signalisation Rho/ROCK. Pour la première fois, dans ces cellules issues de l’entéropathie radique, nous avons montré une surexpression de miR-210 ; microRNA induit par l’hypoxie. L’association pentoxifylline-trolox inverse la surexpression de miR-210 aussi bien dans les conditions normoxique que dans les conditions hypoxiques. L’implication de miR-210 dans l’entéropathie radique n’a pas été préalablement étudiée, néanmoins nous avons montré qu’un inhibiteur de miR-210 diminue l’expression de Col Iα1 dans ce modèle. L’effet anti-fibrosant exercé par l’association pentoxifylline-vitamine E est partiellement induit par l’inhibition de la cascade TGF-β1. L’inhibition de miR-210 est un deuxième mécanisme potentiel nécessitant d’autres investigations. Cette étude renforce les essais clinique antérieurs en montrant in vitro une synergie entre pentoxifylline et vitamine E et permettant de proposer cette association en première ligne thérapeutique dans la fibrose radio-induite. De plus, miR-210 est proposé comme une possible cible thérapeutique pour traiter la fibrose radio-induite
Radiation-induced fibrosis is a serious late complication of radiotherapy. Pentoxifylline-vitamin E has proven effective and safe in clinical trials as treatment of fibrosis, while the molecular mechanism of its activity is yet unexplored. We showed efficacy of Pentoxifylline-vitamin E combination in radiation-induced enteropathy in a small clinical study. In parallel, using a unique in vitro model of primary smooth muscle cells isolated from intestinal samples isolated from humans with radiation enteropathy we showed that pentoxifylline and the hydrophilic analogous of vitamin E (trolox) synergize to inhibit TGF-β1 protein and mRNA expression. This inhibitory action is mediated at the transcriptional level and leads to subsequent inhibition of TGF-β1/Smad targets (Col Iα1, FN1, PAI-1, CTGF), while it has no effect on the Rho/Rock pathway. We have also demonstrated, for the first time, an overexpression of the hypoxia-induced microRNA miR-210 in the fibrotic cells. Pentoxifylline-trolox combination could reverse this miR-210 overexpression in normoxic and hypoxic conditions. While miR-210 has not been previously shown to be involved in radiation-induced enteropathy, we showed that miR-210 inhibitor could reduce mRNA expression of Col Iα1. The anti-fibrotic effect of combined pentoxifylline-vitamin E is at least in part mediated by inhibition of the TGF-β1 cascade. MiR-210 inhibition is another mechanism which needs further investigations. This study strengthens previous clinical data showing pentoxifylline-vitamin E synergy and supports its use as a first-line treatment of radiation-induced fibrosis. Also, it suggests miR-210 as a new potential therapeutic target for the treatment of this complication
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3

Kadokawa, Yoshio. "All-trans retinoic acid prevents radiation-or bleomycin-induced pulmonary fibrosis." Kyoto University, 2009. http://hdl.handle.net/2433/124297.

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4

Okoshi, Kae. "All-trans-retinoic acid attenuates radiation-induced intestinal fibrosis in mice." Kyoto University, 2008. http://hdl.handle.net/2433/135833.

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5

Lemay, Anne-Marie. "Identification of bleomycin and radiation-induced pulmonary fibrosis susceptibility genes in mice." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92173.

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6

Lavigne, Jérémy. "Changements phénotypiques des cellules endothéliales irradiées au cours du développement des lésions radiques pulmonaires." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066308/document.

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La radiothérapie thoracique peut induire le développement de pneumopathies aiguës et de fibroses. La dysfonction du système vasculaire participe au développement de lésions radiques. Dans l'intestin, un KO endothélial de PAI-1 protège les souris de la fibrose radique. Le premier objectif de ce projet est d'explorer le rôle de PAI-1 dans l'apparition de la fibrose radique pulmonaire. L'irradiation thoracique de souris à 17 Gy altère sévèrement le parenchyme pulmonaire et l'analyse histologique révèle que l'invalidation de PAI-1 aggrave les lésions à 2 et 13 semaines. Cette invalidation ne protège donc pas les animaux des dommages radiques pulmonaires. L'organisation en parallèle du poumon permet d'envisager une tolérance à de fortes doses par fraction sur des petits volumes. Des irradiations en conditions stéréotaxiques ont donc été réalisées chez la souris. Les analyses histologiques montrent une déstructuration alvéolaire et un fort infiltrat inflammatoire au niveau de la zone cible. Un œdème est observable dans l'ensemble du poumon ipsilatéral deux semaines après irradiation. Le poumon ipsilatéral est également affecté par des altérations de structure, tel un épaississement des septa alvéolaires. Ces bouleversements se traduisent également au niveau transcriptomique. A la vue de l'ensemble de ces altérations, un test à l'effort a été réalisé pour évaluer l'impact potentiel sur la fonction pulmonaire. Les résultats mettent en évidence une diminution des performances des animaux. Les analyses sont à approfondir mais elles démontrent l'importance de s'intéresser aux tissus sains situés hors du volume cible mais recevant des fractions variables de la dose délivrée
Radiation-induced endothelial dysfunction is known to participate to the development of normal tissue damage. PAI- is implicated in the phenotypic changes of irradiated endothelial cells and KOendo mice are protected from radiation damage to the gut. Whole thorax of PAI-1 KOendo and floxed mice were exposed to 17 Gy. Histological analyzes showed that PAI-1 KOendo induces a worsening of injuries at 2 and 13 weeks. Consequently, contrary to the gut no protection from radiation-induced lung damage is observed in PAI-1 KOendo mice. Our second aim was to study the effects of a single high dose stereotactic irradiation on pulmonary tissues. Histological analyzes and scanner imaging show important injuries on the targeted volume. An ipsilateral edema can also be observed 2 weeks after irradiation. Ipsilateral lung is moreover importantly damaged. A thickening of alveolar septa is notably observable. A transcriptomic analysis show important similarities between tissues from the ipsilateral lung and the focal lesion. As really highly damages have been observed in both scanner and histological analyzes, we decided to perform forced physical activity test on treadmill. A drastic decrease of maximal distance traveled has been observed from two weeks. These experiments highlighted a deficiency in respiratory function and all of these results show the importance of non-targeted irradiated pulmonary volume in the development of radiation-induced fibrosis. Effect of an endothelium-specific deletion of HIF-1α has been investigated in this model of stereotactic irradiation. Only few differences have been observed between KOendo and control mice. Experiments are still ongoing
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Cappuccini, Federica [Verfasser], and Verena [Akademischer Betreuer] Jendrossek. "Radiation-induced pneumonitis and fibrosis - Defining the role of immune cells and regulatory molecules / Federica Cappuccini ; Betreuer: Verena Jendrossek." Duisburg, 2017. http://d-nb.info/1141053586/34.

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8

Dardaillon, Rémi. "Fibres optiques passives et actives sous irradiation : application à l'amplification et à la dosimétrie en environnement spatial." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTS052/document.

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Les fibres dopées erbium couvrent de nombreuses applications, particulièrement dans le domaine des télécommunications terrestres et sous marines, avec les amplificateurs optiques. Aujourd’hui, il existe un réel intérêt pour l’industrie spatiale d’utiliser ces fibres dans les satellites. Cependant, pour utiliser leur potentiel, une qualification en milieu radiatif doit être effectuée, c'est justement l'objet principal de ce travail de thèse. Grâce au partenariat industriel avec Draka-Prysmian, nous avons accès à une grande diversité de fibres en termes de compositions chimiques : ceci nous permet d’étudier leur sensibilité aux radiations, et de comprendre le rôle essentiel des dopants et des codopants dans cette sensibilité. Une étude de celle-ci en temps réel, associée à une caractérisation pré et post-irradiation des fibres optiques, rend possible l'identification fine des défauts induits sous irradiation, et la compréhension de leur mécanisme de formation, en fonction de la composition de ces fibres. Cette étude permet ainsi de proposer un modèle physique de leur dégradation, et aussi de leur guérison, complété par un modèle d'amplificateur. Il permet de prédire, en fonction de la composition des fibres, le comportement quantitatif des amplificateurs optiques associés, en termes de gain et et de bande passante, versus un dépôt de dose typique d'une mission spatiale ; il répond ainsi aux attentes des principaux acteurs du domaine. En outre, le bénéfice de ce travail ouvre des portes dans le domaine de la dosimétrie par fibre optique active, dans différents environnements radiatifs autres que le domaine spatial, tels que le milieu médical ou l'environnement nucléaire
Erbium-doped optical fibers open up many applications, especially in the field of terrestrial and underwater telecommunications, with optical amplifiers. Nowadays, there is a real interest for the space industry to use these fibers in satellites. However, in order to use their full potential, qualification in radiative environments is to be carried out, this is the main focus of this PhD work. Thanks to the partnership with Draka-Prysmian group, we have a full access to a large diversity of specialty fibers, in terms of chemical compositions : this allows us to study their sensitivity to radiations, and to determine the important role of dopants and co-dopants in this sensitivity. A real-time study of it, associated with a qualification of pristine and irradiated optical samples, enables the detection of radiation-induced defects, and the understanding of their creation process, as a function of the fiber structure. This study provides a physical model describing the degradation and the recovery of these fibers, enhanced with an amplifier modeling. It allows the prediction of the quantitative behavior of specialty fiber-based amplifiers, in terms of gain and bandwidth, versus the chemical composition of the fibers used, for a typical space mission dose ; thus this modeling meets the needs of the spatial market key actors. Furthermore, the benefit of this work opens up another avenues for some larger opportunities, in various radiative environments, such as the medical field or the areas of nuclear facilities
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Di, Francesca Diego. "Roles of dopants, interstitial O2 and temperature in the effects of irradiation on silica-based optical fibers." Thesis, Saint-Etienne, 2015. http://www.theses.fr/2015STET4002/document.

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Dans ce travail de thèse, nous avons étudié l'effet des rayonnements ionisants (rayons X et γ) jusqu'à une dose maximale de 1 Grad sur différents types de fibres multimodes (dopées -P, -P-Ce, -Ge, -Ge-F, -Ge-Ce et -N). Les caractérisations ont été réalisées principalement avec trois techniques expérimentales : online Atténuation Induite par Radiation en temps réel (RIA), Résonance Paramagnétique Electronique (EPR), Micro-Luminescence (ML). Dans la première partie du travail de cette thèse, nous avons étudié la réponse aux radiations de différents types de fibres optiques. L'absorption liée aux défauts du phosphore induits par irradiation a été étudiée par des mesures RIA dans le domaine spectral UV-Visible. Les mesures EPR nous permis de détecter les défauts POHC, P1 et P2. En particulier, pour la détection de P1 et P2, nous avons utilisé le mode de détection de la seconde harmonique pour déterminer la cinétique de croissance des P1 et P2 en fonction de la dose. Nous avons également étudié les effets dus au changement des conditions de fibrage et ceux liés à la variation de la température d'irradiation (25-280 ° C). Nous avons aussi étudié l’effet du codopage du coeur de la fibre avec du Cérium. Dans ce cas, nous avons observé une production moins importante de centres POHC et P2 sous irradiation. De plus, les mesures EPR ont montré que la génération des défauts P1 n’est pas sensiblement influencée par le codopage avec le Cérium. En ce qui concerne les fibres optiques dopées Ge, on a étudié trois types de dopage : Ge seul, co-dopage Ge-F et Ge-Ce. Pour chaque type, nous avons examiné trois conditions de fibrage. La réponse à l’irradiation de ces fibres a été étudiée par les trois techniques utilisées. Plus particulièrement la ML, nous a permis d'obtenir une vision plus complète du rôle du codopant et des précurseurs dans la formation des défauts induits par l'irradiation. Nous avons également étudié la réponse au rayonnement de la fibre dopée N avec trois différentes conditions de fibrage. Les réponses à l’irradiation dans les régions spectrales UV-visible ont été obtenues par des mesures RIA. Par EPR, nous avons pu détecter deux défauts liés à l'azote pour les doses élevées de radiation. Enfin, les mesures ML sur les fibres irradiées ont montré trois bandes d'émission dans le visible qui ont été attribuées clairement à des centres émetteurs liés à l'azote. Dans la deuxième partie de la thèse, nous avons étudié les effets liés au chargement en oxygène des fibres étudiées. Par des mesures en microspectroscopie Raman, nous démontrons qu'un traitement à haute température et haute pression peut favoriser l’introduction d’une grande quantité de O2 dans les fibres optiques à cœur de silice pure (PSC) ou dopées F, Ge ou P. Les réponses à l’irradiation de certaines des fibres optiques chargées en O2 ont été étudiés (et en particulier PSC et celle dopée F. Sur la base des données de la littérature, nous avons effectué les décompositions des spectres RIA en fonction de la dose. De plus, l'étude EPR des fibres optiques dopées P et chargées en O2 a montré une forte réduction des défauts P1 et P2 comparées aux fibres non traitées. Dans cette partie de la thèse, j’ai également présenté les résultats concernant la radioluminescence infrarouge (1272 nm) des molécules O2 dans la fibre optique. La faisabilité d'un capteur de radiation pour des environnements sous fortes doses et forts débits de dose a été discutée
In this Thesis work we have investigated the effect of ionizing irradiation (X and γ rays) up to 1 Grad on different types of multimode optical fibers (P-doped, P-Ce-doped , Ge-doped, Ge-F-doped, Ge-Ce-doped, and N-doped). The experiments were carried out by three main experimental techniques: online Radiation Induced Attenuation (RIA), Electron Paramagnetic Resonance (EPR) and Confocal Micro-Luminescence (CML). In the first part of the Thesis work we report on the radiation response of several types of optical fibers. The absorption due to radiation induced P-related defects was studied by RIA in the UV-Visible domain. Moreover, by EPR measurements we were able to detect POHC, P1 and P2 defects. In particular, for the detection of P1 and P2 defects we have validated the use of EPR second-harmonic detection mode which allowed us to obtain the growth kinetics of P1 and P2 with the dose. The effects due to the variation of the drawing conditions of the fibers were investigated as well as the ones due to the change of the temperature of irradiation (from 25 to 280 °C). Finally, concerning the P-doped OFs, we report on the effects due to the Cerium codoping of the core of the optical fiber. We observed a reduced generation of POHC and P2 centers under irradiation. However, EPR investigation has shown that the generation of P1 defects is essentially unaffected by the Ce-codoping. Regarding Ge-doped optical fibers we report on three basic typologies: Ge-doped, Ge-F-doped and Ge-Ce-doped. For each fiber typology we investigated three drawing conditions. The radiation responses of these fibers were characterized by RIA and EPR measurements. Furthermore, performing CML measurements we were able to obtain further insight on the role of the co-dopants and of the defect precursors in determining the radiation induced defects. We have also investigated the radiation response of N-doped OFs (three drawing conditions). The radiation responses in the UV-Visible domains were obtained by RIA, and by EPR measurements we were able to detect the signals of two N-related defects at high radiation doses. Finally, CML measurements on irradiated samples have shown three emission bands in the visible domain which are tentatively assigned to N-related centers. In the second part of the Thesis we report on the effects of an O2 loading treatment produces on some of the investigated samples. By micro-Raman measurements we demonstrate that a high pressure high temperature treatment can incorporate high quantity of O2 into Pure-Silica-Core (PSC), F, Ge and P doped optical fibers. The radiation responses of some of the O2-loaded optical fibers were investigated with particular regard to the fluorine doped and pure-silica-core optical fibers. On the basis of literature data we performed band decompositions of the RIA spectra as a function of the dose. Moreover, the EPR study of the O2 loaded P-doped optical fiber have shown a strong reduction of the signals associated to the P1 and P2 defects as compared to the untreated fibers. In this part of the thesis we also report on the characterization of the near infrared radioluminescence (1272 nm) of O2 molecules embedded in the optical fiber matrix and the feasibility of a radiation sensor based on this phenomenon for environments characterized by high radiation doses and high dose-rates
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Lecomte, Pierre. "Mesure haute température en environnement irradié par fibre optique utilisant l’effet Raman." Thesis, Perpignan, 2017. http://www.theses.fr/2017PERP0067/document.

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EDF souhaite utiliser la technologie de mesure de température répartie par capteur à fibre optique utilisant l’effet Raman pour réaliser des cartographies de température de certains composants de centrales nucléaires. Les conditions environnementales auxquelles le capteur à fibre optique est soumis sont particulièrement agressives (température de 350 °C et rayonnements gamma ionisants). Les rayonnements ionisants sont responsables de la création de défauts structurels au cœur de la fibre, qui atténuent sa transmission lumineuse, et dont les effets engendrent une erreur de mesure de température pouvant aller jusqu'à l’interruption totale de la mesure. La haute température, quant à elle, dégrade le revêtement protecteur de la fibre optique, ce qui la fragilise mécaniquement. Des irradiations gamma in situ sur des fibres optiques multimodes commerciales à revêtement or protégées par une gaine en acier inoxydable ont été réalisées, à l’aide de deux sources de rayonnements différentes, pour observer l'atténuation radio-induite du capteur à fibre optique en fonction du débit de dose et de la dose cumulée. Les effets du rayonnement à température ambiante, puis à haute température, ont été observés. Ce travail expérimental démontre que la haute température peut être maîtrisée grâce à une fibre à revêtement or, et que la haute température est bénéfique contre l’atténuation de la fibre engendrée par l’irradiation. La mise en œuvre de capteur de température à fibre optique en environnement sévère devient possible, ainsi que l’estimation des incertitudes sur la mesure associée
EDF is working on Raman distributed temperature sensing using optical fiber sensors in order to map temperature of nuclear power plants big components. The sensor has to sustain harsh environmental conditions (temperatures up to 350 °C and gamma ionizing radiations). Ionizing radiations can create structural defects inside the fiber’s core, which attenuate the light transmission. This phenomenon can lead to temperature measurements errors until no measurement is possible. As for high temperature, it can affect the fiber coating, which mitigate the fiber mechanical resistance.Gamma rays in situ irradiations have been carried out over commercial off-the-shelf multimode gold coated fibers protected with a stainless steel metal tubing, with two different radiation sources, in order to observe radiation-induced attenuation over dose rate or cumulated dose. Effects of gamma rays over gold coated optical fiber sensors have been observed at both room anhigh temperature.This experimental work enlightens that high temperature can be controlled with gold coated fibers, and that the radiation-induced attenuation downsides can efficiently be balanced with high temperature. Implementation of a Raman distributed temperature optical fiber sensor in such harsh environments becomes possible, as well as the associated estimation of measurement uncertainty
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Частини книг з теми "Radiation-induced fibrosi"

1

Rodemann, H. Peter, Anke Binder, and Michael Bamberg. "Radiation-Induced Fibrosis: Experimental Studies." In Late Sequelae in Oncology, 93–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-46794-3_13.

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Jacobson, Geraldine. "Pentoxifylline, Vitamin E, and Modification of Radiation-Induced Fibrosis." In Oxidative Stress in Cancer Biology and Therapy, 357–72. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-397-4_17.

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Sime, Patricia J., R. Matthew Kottmann, Heather F. Lakatos та Thomas H. Thatcher. "The Role of TGF-β in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-β as a Novel Therapeutic Strategy". У Transforming Growth Factor-β in Cancer Therapy, Volume I, 629–47. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-292-2_40.

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Ward, William F., and Yoon T. Kim. "Radiation-Induced Pulmonary Fibrosis." In CRC Handbook of Animal Models of Pulmonary Disease, 165–82. CRC Press, 2018. http://dx.doi.org/10.1201/9781351070966-10.

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Rosenow, Edward C. "Pulmonary Disease in the Immunocompromised Host (ICH)." In Mayo Clinic Challenging Images for Pulmonary Board Review, 893–98. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199756926.003.0116.

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1. Opportunistic infection • 75% with diffuse disease • 25% with focal disease 2. Drug-induced pulmonary disease • 5% to 25% • “Idiopathic fibrosis” probably a drug or radiation cause (or both) 3. Recurrence of underlying disease • Most commonly with hematologic diseases 4. “Unrelated”...
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Perez, Jessica Rika. "Radiation-Induced Lung Injury Imaging." In Emerging Developments and Practices in Oncology, 218–38. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-3085-5.ch008.

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Radiation-induced lung injury (RILI) occurs in up to 30% of thoracic radiotherapy (RT) cases and is a major limiting factor of dose escalation to achieve tumor control and improve survival. RILI can be separated into two phases: an early inflammatory phase and a late fibrotic phase. Imaging has the potential to provide a helpful understanding of RILI for diagnosis, monitoring and treatment. Current clinical imaging methods rely on anatomical imaging and occasionally incorporate functional imaging. With the advent of molecular imaging, specific targeted probes can be designed to image RILI at every stage of the process. Molecular imaging is still in its infancy and most new RILI imaging techniques are still under development. This chapter summarizes the different imaging methods used clinically for RILI imaging and explores new developments for the future of RILI management.
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JIRTLE, R. L., and M. S. ANSCHER. "THE ROLE OF TGF-β1 IN THE PATHOGENESIS OF RADIATION INDUCED HEPATIC FIBROSIS." In Radiation Research: A Twentieth-century Perspective, 27. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-12-168561-4.50043-3.

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Jirtle, Randy L., and Mitchell S. Anscher. "THE ROLE OF TGF-β1 IN THE PATHOGENESIS OF RADIATION-INDUCED HEPATIC FIBROSIS." In Congress Proceedings, 819–23. Elsevier, 1992. http://dx.doi.org/10.1016/b978-0-12-168562-1.50146-4.

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De Broe, Marc E., Channa Jayasumana, Patrick C. D’Haese, Monique M. Elseviers, and Benjamin Vervaet. "Chronic tubulointerstitial nephritis." In Oxford Textbook of Medicine, edited by John D. Firth, 4956–74. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0490.

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Chronic tubulointerstitial nephritis is usually asymptomatic, presenting with slowly progressive renal impairment. Urinalysis may be normal or show low-grade proteinuria (<1.5 g/day) and/or pyuria. Diagnosis depends on renal biopsy, which reveals variable cellular infiltration of the interstitium, tubular atrophy, and fibrosis. There are many causes including sarcoidosis, drugs (prescribed and nonprescribed), irradiation, toxins, and metabolic disorders. Analgesic nephropathy—characterized by renal papillary necrosis and chronic interstitial nephritis and caused by the prolonged and excessive consumption of combinations of analgesics, mostly including phenacetin. Nonsteroidal anti-inflammatory drugs—the most frequent cause of permanent renal insufficiency after acute interstitial nephritis. Aristolochic acid nephropathy—(1) Chinese herb nephropathy—caused in most cases (but perhaps not all) by aristolochic acid, and is associated with a high incidence of urothelial malignancy. (2) Balkan endemic nephropathy—a chronic, familial, noninflammatory tubulointerstitial disease of the kidneys that is associated with a high frequency of urothelial atypia, occasionally culminating in tumours of the renal pelvis and urethra. 5-Aminosalicylic acid—used in the treatment of chronic inflammatory bowel disease and causes clinical nephrotoxicity in approximately 1 in 4000 patients/year. Chronic interstitial nephritis in agricultural communities (CINAC) —nonproteinuric chronic kidney disease that presents in young, agricultural workers in Central America and Sri Lanka in the absence of any clear aetiology. Lithium—the most common renal side effect is to cause nephrogenic diabetes insipidus. Radiation nephropathy—preventive shielding of the kidneys in patients receiving radiation therapy generally prevents radiation nephropathy, but total body irradiation preceding bone marrow transplantation leads 20% to develop chronic renal failure in the long term. Nephropathies induced by toxins (including lead and cadmium) or by metabolic disorders (chronic hypokalaemia and chronic urate nephropathy).
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Harada, Aki, Wei Li, Chao Li, Michael Idowu, Mitchell S. Anscher, and Youngman Oh. "Statin Inhibits Radiation-Induced Fibrosis through Regulation of CTGF/IGFBP-rP2 Action in Lung Fibroblasts." In BASIC/TRANSLATIONAL - IGF & IGF Binding Proteins, P1–151—P1–151. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part1.p6.p1-151.

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Тези доповідей конференцій з теми "Radiation-induced fibrosi"

1

Henschel, H., O. Kohn, and H. U. Schidt. "Radiation Damage And Radiation Induced Loss In Optical Fibres." In OE/FIBERS '89, edited by Roger A. Greenwell and Dilip K. Paul. SPIE, 1990. http://dx.doi.org/10.1117/12.963227.

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Asha, S., N. Parushuram, K. S. Harish, S. Ganesh, and Y. Sangappa. "Radiation induced effects on silk fibroin films." In ADVANCES IN BASIC SCIENCE (ICABS 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5122576.

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Yang, Xiaofeng, Peter Rossi, Joseph Shelton, Debrorah Bruner, Srini Tridandapani, and Tian Liu. "3D ultrasound Nakagami imaging for radiation-induced vaginal fibrosis." In SPIE Medical Imaging, edited by Johan G. Bosch and Marvin M. Doyley. SPIE, 2014. http://dx.doi.org/10.1117/12.2043862.

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Theodosiou, Antreas, Arnaldo Leal, Carlos Marques, Anselmo Frizera, Antonio Fernandes, Andrei Stancalie, Andreas Ioannou, Daniel Negut, and Kyriacos Kalli. "Radiation induced effects on FBGs using different femtosecond laser inscription methods." In Micro-structured and Specialty Optical Fibres VII, edited by Pavel Peterka, Kyriacos Kalli, and Alexis Mendez. SPIE, 2021. http://dx.doi.org/10.1117/12.2592376.

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5

West, R. H. "Radiation Induced Losses In Pure Silica Core Fibres." In Cambridge Symposium-Fiber/LASE '86, edited by Roger A. Greenwell. SPIE, 1987. http://dx.doi.org/10.1117/12.937628.

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Caussanel, M., G. Beauvois, H. Duval, S. Grieu, G. Montay, and O. Gilard. "Radiation-Induced Attenuation Data of Polarization-Maintaining Fibres." In 2017 17th European Conference on Radiation and Its Effects on Components and Systems (RADECS). IEEE, 2017. http://dx.doi.org/10.1109/radecs.2017.8696161.

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Kashaykin, Pavel F., Alexander L. Tomashuk, Irina S. Azanova, Olga L. Vokhmyanina, Tatiana V. Dimakova, Igor A. Maltsev, Yulia O. Sharonova, Elena A. Pospelova, and Evgueni M. Dianov. "Gamma-radiation-induced attenuation of light in polarization-maintaining pure-silica-core PANDA fibers." In Micro-structured and Specialty Optical Fibres, edited by Pavel Peterka, Kyriacos Kalli, and Alexis Mendez. SPIE, 2019. http://dx.doi.org/10.1117/12.2520430.

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Palmer, M. "Monocarboxylate Transporter (MCT) Proteins as Targets for Radiation-Induced Pulmonary Fibrosis." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5338.

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Degan, Simone. "Gastrin-Releasing Peptide (GRP) Promotes Radiation-Induced Pulmonary Inflammation And Fibrosis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1998.

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Wu, Szu-yuan. "Abstract 4151: Fucoidan reduced radiation-induced fibrosis and secondary primary cancers." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4151.

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