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Дисертації з теми "Quinone"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Oosthuizen, Francois Jacobus. "Syntheses of the enantiopure quinones A and A' and their C-1 epimers." Thesis, Oosthuizen, Francois Jacobus (2002) Syntheses of the enantiopure quinones A and A' and their C-1 epimers. PhD thesis, Murdoch University, 2002. https://researchrepository.murdoch.edu.au/id/eprint/234/.

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Анотація:

The 3,4-dihydro-1H-naphtho[2,3-c]pyran ring system is found in many natural products as the 5,10- or 6,9-quinones. These compounds have been synthesized by various research groups as a result of their wide range of biological activities. This thesis describes several investigations directed towards syntheses of compounds in this general area. Quinone A (16) and quinone A'(17), derived from the naturally occurring aphid insect pigments protoaphin-fb and protoaphin-sl respectively, were of particular interest. The first chapter describes the previous syntheses of some naphtho[c]pyrans includi

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2

Oosthuizen, Francois Jacobus. "Syntheses of the Enantiopure Quinones A and A' and Their C-1 Epimers." Murdoch University, 2002. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20040820.123649.

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Анотація:

The 3,4-dihydro-1H-naphtho[2,3-c]pyran ring system is found in many natural products as the 5,10- or 6,9-quinones. These compounds have been synthesized by various research groups as a result of their wide range of biological activities. This thesis describes several investigations directed towards syntheses of compounds in this general area. Quinone A (16) and quinone A(17), derived from the naturally occurring aphid insect pigments protoaphin-fb and protoaphin-sl respectively, were of particular interest. The first chapter describes the previous syntheses of some naphtho[c]pyrans including

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3

Cassagnes, Laure-Estelle. "Cycle redox quinone-quinone réductase 2 et conséquences sur la production d'espèces oxygénées réactives dans le contexte cellulaire." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30148/document.

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La quinone réductase 2 ou QR2 est une enzyme qui, comme son homologue QR1, joue un rôle de détoxification des quinones, molécules fortement réactives, en les réduisant en hydroquinones. Cependant, il a été observé au niveau cellulaire et tissulaire que l'activité de cette flavoprotéine pouvait avoir des effets délétères en déclenchant une surproduction d'espèces réactives de l'oxygène (ROS). D'autre part, on observe une surexpression ou une sous expression de QR2 dans certaines maladies neurodégénératives comme la maladie de Parkinson et la maladie d'Alzheimer. Dans ce contexte, ce travail a p

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4

Minhas, Gurdeep Singh. "Interaction of quinone and quinone-like inhibitors with Thermus thermophilus complex I." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707994.

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5

Chauncey, Marek Anthony. "Reactions heterocyclic quinone methides." Thesis, University of Ulster, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328193.

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6

Chhour, Monivan. "Etude de la métabolisation intracellulaire de quinones, du stress oxydant généré et des processus de détoxification associés." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30004.

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Анотація:

Les quinones sont des composés ubiquitaires naturels indispensables aux organismes vivants. Cependant leur métabolisation est considérée comme toxique en raison de leur réactivité élevée. Les quinones sont en effet facilement réductibles à un ou deux électrons. La métabolisation intracellulaire de ces quinones par des réductases à un électron telles que le cytochrome P450 réductase ou d'autres flavoprotéines génèrent des semiquinones instables à l'origine de la production de radicaux libres conduisant à un stress oxydant. Les quinones-réductases 1 et 2 (QR1 et QR2) catalysent leur réduction à

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7

Colucci, Marie A. "Quinone based inhibitors of NQ01." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478964.

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8

Sunassee, Suthananda Naidu. "Studies in marine quinone chemistry." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1005020.

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Анотація:

This thesis is divided into two parts and the rationale of the research conducted is based on the cytotoxicity of the prenylated quinones 1.24-1.29, isolated from the South African nudibranch Leminda millecra, against oesophageal cancer cells. The first part (Chapters 2 and 3) of the thesis initially documents the distribution of cytotoxic and antioxidant prenylated quinones and hydroquinones in the marine environment. We have been able to show, for the first time, that these compounds can be divided into eight structural classes closely related to their phyletic distribution. Secondly, we att

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9

Ferreira, Janaina Gomes. "Estudo de compostos quinônicos com potencial atividade contra a doença de Chagas." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/75/75131/tde-23062008-163355/.

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Este trabalho apresenta as estruturas determinadas por difração de raio X de dois compostos naftoquinônicos, 3,4-diidro-[2,2-dimetil]-2H-nafto[1,2-b]pirano-5,6-diona (β-lapachona) e dimetil-1,4-naftoquinona. A estrutura cristalina destes compostos mostrou que estes são estabilizados por ligações de hidrogênio do tipo C-H...O, formando estruturas supramoleculares. Dos compostos derivados da β-lapachona, os naftoimidazóis têm-se mostrado muito ativos contra o T. cruzi, agente causador da doença de Chagas. Partindo das estruturas modeladas de 29 compostos naftoimidazólicos, propriedades

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10

Cardoso, Mariana Filomena do Carmo. "Síntese de derivados 5-amino-1H-pirazólicos da nor-β-lapachona com potencial perfil anticancerígeno". Niterói, 2017. https://app.uff.br/riuff/handle/1/3283.

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Анотація:

Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-04-04T18:00:06Z No. of bitstreams: 1 Cardoso, Mariana Filomena do Carmo [Dissertação, 2012].pdf: 7461706 bytes, checksum: 1ba99c29719229ef773ca5d72b10c91f (MD5)<br>Made available in DSpace on 2017-04-04T18:00:06Z (GMT). No. of bitstreams: 1 Cardoso, Mariana Filomena do Carmo [Dissertação, 2012].pdf: 7461706 bytes, checksum: 1ba99c29719229ef773ca5d72b10c91f (MD5)<br>Esse trabalho descreve uma nova metodologia sintética de novos derivados pirazólicos análogos a 2,2-dimetil-2,3-di-hidronafto[1,2-b]furan-4,5-diona (nor-β

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11

Urdang, Zachary D. "Towards Quinone Methids Releasing Disassembling Dendrimers." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146912.

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12

Cossette, Michael Vernie. "The Synthesis of Quinone-Capped Cyclodextrins." W&M ScholarWorks, 1988. https://scholarworks.wm.edu/etd/1539625451.

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13

Greenaway, Kevin. "Development of methodologies for the organocatalytic addition of pro-nucleophiles to o-quinones and o-quinone methides." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525288.

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14

Chen, Chung-pin. "Part I: Steric and inductive effects on the hydrolysis of quinone bisketals ; Part II: A convenient route to ortho-alkylated phenols and quinone monoketals. Part III: A general approach to quinone ketals. Part IV: Preparation and chemistry of quinone... /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487268021749158.

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15

Giraud, Luc. "Synthèses d'agents alkylants bioréductibles en série 1,4-benzoquinonique : étude de leur réactivité dans des réactions de transfert monoélectronique." Aix-Marseille 3, 1992. http://www.theses.fr/1992AIX30033.

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Анотація:

Ce travail est consacre a la synthese de derives quinoniques substitues par un groupement nucleofuge en position benzylique et a l'etude de leur reactivite dans des reactions de transfert monoelectronique. L'etude mecanistique de la reaction de ces agents alkylants bioreductibles avec le sel de lithium du 2-nitropropane et l'etude de ces composes par les techniques electrochimiques et de rpe ont permis pour cette reaction de satisfaire les principaux criteres de la mise en evidence d'un mecanisme de substitution radicalaire-nucleophile unimoleculaire (s#r#n#1). L'extension de cette reaction a

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16

Fernando, J. Roshan C. "Theoretical studies on quinone reactivity a thesis presented to the faculty of the Graduate School, Tennessee Technological University /." Click to access online, 2009. http://proquest.umi.com/pqdweb?index=50&did=1908035911&SrchMode=1&sid=1&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1265041952&clientId=28564.

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17

Leach, Graeme Richard. "Regulation of respiratory activity in plant mitochondria : interplay between the quinone-reducing and quinol-oxidising pathways." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320417.

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18

Humphries, Matthew Philip. "NAD(P)H Quinone Oxidoreductase 1 (NQO1) and NRH Quinone Oxidoreductase 2 (NQO2) : their inhibition by triazoloacridinones and imidazoacridinones." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/nadph-quinone-oxidoreductase-1-nqo1-and-nrh-quinone-oxidoreductase-2-nqo2-their-inhibition-by-triazoloacridinones-and-imidazoacridinones(f5753d13-fffb-4ca6-9e99-bd475f6eb498).html.

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The human enzymes NQO1 and NQO2 are cytosoloic flavoproteins that catalyze the two electron reduction of a broad range of quinone substrates. NQO1 and 2 are over-expressed in several types of tumours, consequently making them attractive targets for drug development. Inhibition of NQO1 and NQO2 has been shown to reduce the development of some cancers. However current agents demonstrate off target effects and therefore more pharmacologically applicable compounds are needed. Initially a computational screen of the NCI database identified NSC 645827, a triazoleacridin-6-one (TA) with an IC50 of 0.

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19

Mbiya, Wilbes. "Substituent Effects on Reactivity and Allergenicity of Benzoquinone." PDXScholar, 2013. https://pdxscholar.library.pdx.edu/open_access_etds/1406.

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Benzoquinone (BQ) is an extremely potent electrophilic contact allergen that haptenates endogenous proteins through Michael addition (MA). It is also hypothesized that BQ may haptenate proteins via free radical formation. The objective of this study was to assess the inductive effects (activating and deactivating) of substituents on BQ reactivity and the mechanistic pathway of covalent binding to nucleophilic thiols. The BQ binding by Cys34 on human serum albumin was studied, and for reactivity studies, nitrobenzenethiol (NBT) was used as a surrogate for protein binding of the BQ and benzoquin

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20

Taljaard, Jana Heloïse. "Synthesis, properties and reactions of Novel Quinone Methides." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/616.

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Novel p-quinone methides have been synthesized by the dealkylation of 5-(p-alkyloxyaryl)- 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ols and related compounds. Aspects of the dealkylation reaction were investigated using computational methods in order to identify possible intermediates and postulate reasons for the observed reactivity patterns. This included studying the effect of varying the size of the central B-ring, changing the alkyloxy group, and altering the substitution pattern on the parent alcohols. We have assessed the relative energies of reaction intermediates and have also evalua

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21

McCracken, Paul G. "The biological chemistry of quinone methides and benzisoxazoles." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22479.pdf.

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22

Loughran, Michael Gerard. "Quinoprotein dehydrogenase and pyrroloquinoline quinone modified enzyme electrodes." Thesis, Cranfield University, 1995. http://dspace.lib.cranfield.ac.uk/handle/1826/6457.

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This thesis concerns the use of the coenzyme PQQ and quinoprotein dehydrogenase enzymes for the development of enzyme electrodes. A general introduction to the area which describes the properties of quinoprotein dehydrogenases is given. The reactivity and redox properties of the quinone cofactor, PQQ, are also outlined.

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23

Parry, Joel D. "Transcriptomic assessment of quinone mediated hepatic oxidative stress." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/30781.

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Quinone based drugs are complex structures with multiple chemical properties. Therefore in this work to further understand quinone toxicity in drugs simpler structures with defined chemistry were used as tools. To discern mechanistic insight transcriptomic investigations were undertaken in rat hepatocytes and in vivo mouse liver exposed to a range of prototypical quinines. Genes important in response to quinone exposure were identified and analysed using several bioinformatic tools. Transcriptomics in hepatocytes could not differentiate quinone redox effects from other interactions, although 2

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24

Zhu, Tianxia. "Detection of Thiols by o-Quinone Electrocatalytic Sensors." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1340981269.

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25

Boone, Harold Wesley 1969. "Polyaromatic quinone diimines: A novel family of polymers." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290592.

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Polyaniline has attracted much interest due to its unusual physical properties. A polycondensation route to polyanilines is a desirable alternative to the currently used non-discriminating oxidative polymerization. The oxidative synthesis does not allow structural diversity in the monomer and the polymer's structure is not well defined. A synthetic route to polyanthraquinone diimines was recently developed in this laboratory. These pernigraniline analogs are similar in structure to the fully oxidized polyaniline and may display electrical conductivity and optoelectronic properties. The aim of

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26

Sabuco, Jean-François. "Recherches sur la réactivité chimique et les activités biologiques potentielles liées aux réactions de transfert monoélectronique d'azoles quinoniques." Aix-Marseille 3, 1991. http://www.theses.fr/1991AIX30067.

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Dans ce memoire est decrit la preparation de derives azoliques substitues par un groupement quinonique et un nucleofuge en position benzylique. Les syntheses mises au point sont selectives et les differents composes imidazoliques, oxazoliques et thiazoliques sont obtenus sous forme d'un seul isomere au niveau de l'heterocycle. Ces substrats ont une structure d'agent alkylant bioreductible et leur reactivite vis a vis du sel de lithium du 2-nitropropane a ete etudiee dans des reactions de substitution par transfert d'electron. La structure des molecules a une influence determinante sur le derou

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27

Andersen, Svend Olav, Martin G. Perter, and Peter Roepstorff. "Cuticle-catalyzed coupling between N-acetylhistidine and N-acetyldopamine." Universität Potsdam, 1992. http://opus.kobv.de/ubp/volltexte/2008/1676/.

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Several types of insect cuticle contain enzymes catalyzing the formation ofof adducts between N-acetyldopamine (NADA) and N-acetylhistidine (NAH). Two such adducts, NAH-NADA-I and NAH NADA-II, have been isolated and their structures determined. In one of the adducts the link connecting the two residues occurs between the I-position (ß-position) in the NADA side chain and the 1-N atom (τ-N) in the imidazole ring of histidine. Diphenoloxidase activity alone is not sufficient for formation of this adduct, whereas extracts containing both diphenoloxidase and o-quinone-p-quinone methide isomerase a

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28

Franjesevic, Andrew Joseph. "Design, Synthesis, and Evaluation of Therapeutics for the Treatment of Organophosphorus Poisoning by Nerve Agents and Pesticides." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563349257142378.

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29

Diao, Li. "Photogeneration and chemistry of quinone methides from hydroxybenzyl alcohols." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ37339.pdf.

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30

Refaey, Rana Hosny. "Structural and mechanistic studies of quinone oxidoreductase II (NQO2)." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/13566/.

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Анотація:

Flavoenzymes are a widely diverse group of enzymes that are able to catalyze a variety of different chemical reactions. A growing interest in flavoenzymes capable of reducing aromatic nitro groups may be attributed to their ability to reduce anticancer prodrugs such as CB 1954. Similarly, quinine oxidoreductases are able to activate anticancer prodrugs such as mitomycin derivatives by reducing the quinone derivative to the hydroxyl derivative. Some oxidoreductases are able to reduce nitro aromatic compounds. These enzymes may be either mammalian such as NQO1 and NQO2 which are over expressed i

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31

Soper, R. J. "The synthesis and biological activities of natural quinone metabolites." Thesis, University of Essex, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402818.

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32

McGaw, Oliver. "Studies towards the novel synthesis of benzoisochromane quinone polyketides." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/58538/.

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Granaticin is a structurally unique member of the benzoisochromane quinone (BIQ) family of antibiotics. The molecule and its derivative exhibit a sugar moiety fusted to the naphthazarin core, only exhibited by one other natural compound, by a C-C glycosidic bond and an aldol like bond. The mechanism of enzymatic attachment of this substituent is currently unknown. This project aimed to devise a novel and elegant synthesis towards the granaticin aglycone and other benzoisochromane quinone natural compounds with the long term aim of discerning the mechanism of glycosylation. This thesis shows a

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33

Thomas, Terrance Augustine. "Studies of 1,2-quinone monooximes and their metal complexes." Thesis, London Metropolitan University, 1993. http://repository.londonmet.ac.uk/3299/.

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Анотація:

The chemistry of 1,2-quinone monooximes hi« been reviewed. The synthesis of 5-amlno, 5-alkylamino and 5-acylamino substituted 1,2-benzoquinone monooximes was systematically studied. Thus, It has been found that 5-amino-1,2-benzoquinone-2-oxime (5-AqoH), 5-ethylamino-4-methyl 1-1,2- benzoquinone-2-ox I me (5-Et-4-MeqoH), 5-hexylamino-1,2-benzoquinone-2-oxime (5-HxqoH) and 5-heptylamino-1,2-benzoquinone-2-oxime (5-HptqoH) were best prepared by the reaction of the corresponding phenol with sodium nitrite In the presence of concentrated hydrochloric acid. Under these conditions, N-nitrosation was

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34

Kosgei, Cosmas Kipyego. "Investigation of the effect of basicity and Concentration ofproton accepting bases on the potential of Quinones for highpotential quinone based cathode materials." Thesis, Uppsala universitet, Institutionen för fysik och astronomi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-288369.

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35

Ramdohr, Jurgen Ernst. "Synthesis of naphtho{2,3-c}pyrans including the aphin-derived quinone A'." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/15896.

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Bibliography: pages 76-78.<br>Chapter One describes the synthesis of a trifluoroethylnaphtho-1, 4-quinone via a regiospecific trifluoroacetylation of an appropriately substituted naphthalene. Chapter Two describes the synthesis of the methyl ethers of the naturally occurring quinones A and deoxyquinone A for evaluation of their "anti-cancer" activity by the National Institutes of Health. In Chapter Three the final few steps of the synthesis of the aphid-derived quinone A' are described. This was made possible by the development of an efficient route for the conversion of a precursor to quinone

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36

Longatte, Guillaume. "Dérivation des électrons photosynthétiques par des médiateurs de type quinone." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066322/document.

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La photosynthèse consiste en la conversion photo-induite du dioxyde de carbone et de l'eau en matière organique et en dioxygène. Utilisée par les algues, les plantes ou certaines bactéries, la photosynthèse est pourtant intrinsèquement bridée puisque seulement 4 % de l'énergie lumineuse sont convertis en énergie chimique. Sous forte irradiation, ceci peut engendrer une dénaturation de l'appareil photosynthétique. Par ailleurs, dans le contexte environnemental actuel, cette limitation représente également une opportunité d'utiliser l'énergie non convertie sous forme d'énergie électrique. Le tra

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37

Martin, Claire Marie. "Synthesis and bioactivation of redox-activated quinone prodrugs of guanidine." Thesis, Bangor University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568210.

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This thesis describes the preparation of several novel guanidine derivatives (where X= tetrarnethyl, dipiperidine and dimorpholine); three containing a previously described trimethyl-substituted quinone I and three analogous guanidines containing the novel phenyl-substituted quinone H. These conformationally locked derivatives were tested as substrates in a benzoquinone-based drug delivery system which is activated by the enzyme human quinone-oxidoreductase I (hNQOI). Molecular modelling studies were initially performed and demonstrated that all six derivatives were viable substrates of the en

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38

Cadd, Duncan Howard. "Some potential precursor routes to aromatic polyesters via quinone methides." Thesis, Durham University, 1992. http://etheses.dur.ac.uk/6032/.

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Poly(para-hydroxybenzoic acid) [pHBA] was discovered in the late 1950s and found to have chemical and mechanical properties which make it attractive for use as a high-performance polymer, potentially in engineering applications. However, the same properties make it difficult to fabricate into films or fibres. This thesis examines the philosophy of the precursor approach to intractable polymers as applied to the synthesis of aromatic polyesters generally and to pHBA specifically, by means of a review on the production of benzene derivatives by ring synthesis, and the polymerisation of 1,4-benzo

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39

Moya, Eduardo. "Ortho-quinone methides from the pyrolysis of substituted benzyltriphenylphosphonium compounds." Thesis, University of Kent, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235694.

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40

Raghvani, Dinesh V. "Studies of 1,2-quinone monooximes and their use in synthesis." Thesis, London Metropolitan University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300685.

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41

Marini, Stefano. "Studies on a monoclonal antibody against the coenzyme pyrrolequinoline quinone." Thesis, Cranfield University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359521.

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42

Simpson, Grant J. "Quinone derivatives as novel single-molecule components for nano-electronics." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6309.

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In this thesis, quinone derivative molecules supported on a Cu(110) surface are studied using scanning tunnelling microscopy (STM). The experimentally investigated system is based on the bistable nature of these compounds, and so the work is introduced in the wider context of molecular electronics (Chapter 1). The theory and experimental techniques are also described (Chapters 2 and 3). In Chapter 4 the switching behaviour of azophenine (AP) and azotolyline (AT) is characterised using STM imaging and spectroscopy, and is demonstrated to be based on a hydrogen tautomerisation reaction. The acti

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43

Dollberg, Christopher L. "Zinc and ruthenium quinone diimine complexes: synthesis and photophysical properties." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1071171484.

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44

Dollberg, Christopher Lawrence. "Zinc and ruthenium quinone diimine complexes synthesis and photophysical properties /." Columbus, Ohio Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1071171484.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 171 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Claudia Turro, Dept.of Chemistry. Includes bibliographical references (p. 168-171).

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45

Labenski, Matthew Thomas. "Identification and Characterization of Quinone-Thioether Protein Adducts In Vivo." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/193748.

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Quinones represent an important class of endogenous compounds such as neurotransmitters and coenzyme Q10, electrophilic xenobiotics and environmental toxicants that have known reactivity based on their ability to redox cycle and generate oxidative stress, as well as to alkylate target proteins. 1,4-Benzoquinone (BQ) is a reactive quinone that we have used to help predict target residue covalent binding by such compounds. Hydroquinone glutathione conjugates (HQ-GSH) cause renal cell necrosis by producing reactive oxygen species (ROS) and by adducting proteins preferentially localized in the S3

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46

Westerlund, Kristina. "Exploring amino-acid radicals and quinone redox chemistry in model proteins." Doctoral thesis, Stockholm University, Department of Biochemistry and Biophysics, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8170.

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<p>Amino-acid radical enzymes have been studied extensively for 30 years but the experimental barriers to determine the thermodynamic properties of their key radical cofactors are so challenging that only a handful of reports exist in the literature. This is a major drawback when trying to understand the long-range radical transfer and/or catalytic mechanisms of this important family of enzymes. Here this issue is addressed by developing a library of well-structured model proteins specifically designed to study tyrosine and tryptophan radicals. The library is based on a 67-residue three-helix

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47

Pokharel, Uttam Raj. "ORGANOMETALLIC HETEROCYCLES AND ACENE-QUINONE COMPLEXES OF RUTHENIUM, IRON AND MANGANESE." UKnowledge, 2012. http://uknowledge.uky.edu/chemistry_etds/6.

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A variety of organometallic-fused heterocycles and acene quinones were prepared and characterized. This work was divided into three parts: first, the synthesis of 5,5-fused heterocyclic complexes of tricarbonylmanganese and (1’,2’,3’,4’,5’-pentamethylcyclopentadienyl)ruthenium; second, the synthesis of 1,2-diacylcyclopentadienyl p-cymene complexes of ruthenium(II); and third, synthesis of cyclopentadienyl-fused polyacenequinone complexes of ruthenium, iron and manganese. The first examples of the convenient, versatile and symmetric cyclopentadienyl-fused heterocycle complexes of (1’,2’,3’,4’,5

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Caraher, Mary Clare. "Biological analysis of NRH quinone oxidoreductase 2 (NQO2) using novel inhibitors." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/biological-analysis-of-nrh-quinone-oxidoreductase-2-nqo2-using-novel-inhibitors(bca95b5b-b9d3-4e68-aeb6-d666b7df80e3).html.

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NQO2 is a member of the oxidoreductase family. It is a cytosolic, flavin-dependent, ubiquitous protein that is expressed in many human tumours. Liao and Williams-Ashman discovered the enzyme 51 years ago, however its cellular role has yet to be fully characterised. Intracellular NQO2 activity has been associated with various diseases; cancer, malaria and neurodegenerative disorders including schizophrenia, Alzheimer’s disease and Parkinson’s disease. Some of these associations have been related to the stability and activity of redox-sensitive factor NFκB, as well as tumour suppressor p53. Henc

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Liu, Yang. "Selective delivery of a quinone methide precursor by peptide nucleic acids." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/7809.

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Thesis (M.S.)--University of Maryland, College Park, 2007.<br>Thesis research directed by: Dept. of Chemistry and Biochemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Bayer, Uwe [Verfasser]. "Cerium Complexes for para-Quinone and Carbon Dioxide Activation / Uwe Bayer." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1225740207/34.

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