Статті в журналах: "QTR 1"

1

Elsasser, S., W. M. Long, H. J. Baier, A. D. Chediak, and A. Wanner. "Independent control of mucosal and total airway blood flow during hypoxemia." Journal of Applied Physiology 71, no. 1 (July 1, 1991): 223–28. http://dx.doi.org/10.1152/jappl.1991.71.1.223.

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In the larger airways, the blood circulation forms a subepithelial (mucosal) and outer (peribronchial) microvascular network. This raises the possibility that blood flow in these two networks is regulated independently. We used hypoxemia as a stimulus to induce changes in tracheal mucosal blood flow normalized for systemic arterial pressure (Qtr n) measured with an inert soluble gas technique and total bronchial blood flow (Qbr) and normalized Qbr (Qbrn) measured with an electromagnetic flow probe in anesthetized sheep. Fifteen minutes of hypoxemia [PO2 40 +/- 7 (SD) Torr] decreased mean Qtr n from 1.1 +/- 0.4 to 0.8 +/- 0.4 ml.min-1.mmHg-1.10(2) (-27%; P less than 0.05; n = 7) and increased mean Qbr n from 12.1 +/- 3.2 to 17.1 +/- 5.4 ml.min-1.mmHg-1.10(2) (+41%; P less than 0.05; n = 6). The rise in Qbr correlated with cardiac output (r = 0.68; P less than 0.05). Phentolamine pretreatment (0.1 mg/kg iv) blunted the hypoxemia-related decrease of mean Qtr n (-8%; P = NS). Tyramine (2.5 mg) applied locally to the trachea decreased mean Qtr n significantly after 30 and 45 min by 31 and 19%, respectively (P less than 0.05). 6-Hydroxydopamine (0.2 mg 4 times for 1 h locally applied) prevented the hypoxemia-induced as well as local tyramine-induced decrease in mean Qtr n (0 and 0%).(ABSTRACT TRUNCATED AT 250 WORDS)

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2

Barker, J. A., A. D. Chediak, H. J. Baier, and A. Wanner. "Tracheal mucosal blood flow responses to autonomic agonists." Journal of Applied Physiology 65, no. 2 (August 1, 1988): 829–34. http://dx.doi.org/10.1152/jappl.1988.65.2.829.

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In lightly anesthetized adult sheep, we determined tracheal mucosal blood flow (Qtr) by measuring the steady-state uptake of dimethyl ether from a tracheal chamber created by an endotracheal tube provided with two cuffs. Qtr normalized for carotid arterial pressure [Qtr(n)] was determined before and after the exposure of the tracheal mucosa to aerosolized phenylephrine (0.25-2.0 mg), isoproterenol (0.05-0.8 mg), and methacholine (2.5-20 mg). The same doses of methacholine were also administered during the intravenous infusion of vasopressin. The measurements were repeated after intravenous pretreatment with the respective antagonists phentolamine, propranolol, and atropine. Mean +/- SE base-line Qtr(n) was 1.2 +/- 0.1 ml.min-1.mmHg-1.10(2). The autonomic antagonists had no effect on mean Qtr(n). Phenylephrine produced a dose-dependent decrease in mean Qtr(n) (-70% at the highest dose), which was blunted by phentolamine, and isoproterenol produced a dose-dependent increase in mean Qtr(n) (40% at the highest dose), which was blocked by propranolol. Methacholine failed to alter mean Qtr(n) even when Qtr was first decreased by vasopressin. We conclude that in lightly anesthetized adult sheep 1) base-line Qtr(n) is not under adrenergic or cholinergic control, 2) a locally administered alpha-adrenergic agonist decreases and beta-adrenergic agonist increases Qtr(n) via specific receptor activation, and 3) a locally administered cholinergic muscarinic agonist has no effect on Qtr(n).

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Melo, Thiago de Sousa, José Humberto Vilar da Silva, José Jordão Filho, Fernando Guilherme Perazzo Costa, Patrícia Emília Naves Givisiez, José Andrew de Lira Barbosa, Natalí Estevão da Cruz, Laryssa Querino da Silva Duarte, Janiele Ferreira da Silva, and Veruska Dilyanne Silva Gomes. "Quantitative and qualitative feed restriction for broilers." Research, Society and Development 10, no. 12 (September 23, 2021): e339101220447. http://dx.doi.org/10.33448/rsd-v10i12.20447.

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The objective of this study is to evaluate the influence of five feed restriction programs (FRP) on broiler performance and carcass yield. 425 Cobb 500® broilers were distributed in a completely randomized design with five FRPs and five replicates with 17 broilers. The FRPs were: Program 1 (P1): consumption ad libitum (AL) of control diet from 14 to 42 days; P2: quantitative restriction (QTR) of 10% of AL consumption from 14 to 28 days and AL consumption from 29 to 42 days; P3: AL consumption from 14 to 28 days and QTR from 29 to 42 days; P4: qualitative restriction (QLR) of 10% of the level of crude protein and essential amino acids from 14 to 28 days and AL consumption from 29 to 42 days; and P5: AL consumption from 14 to 28 days and QLR from 29 to 42 days. The broilers of the AL treatment gained more weight (p≤0.01), but had a similar FCR (P>0.05) compared to broilers submitted to QTR from 29 to 42 days. In addition, broilers fed QTR from 14 to 28 days presented a lower FI and a better FCR (p≤0.01) in relation to broilers fed QLR of 14 to 28 (P4) and 29 to 42 days (P5). The broilers fed QTR of 14 to 28 days diet presented a similar FCR as broilers fed AL. The 10% reduction in AL consumption of 14 to 28 d is a viable economical alternative to feed broilers up to 42 days of age.

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Loose, Kim, Justus Rudolph, Martin Schlösser, Maximilian Willauschus, Johannes Rüther, Philipp Schuster, Hermann Josef Bail, Michael Millrose, and Markus Geßlein. "Quadriceps Tendon Ruptures in Middle-Aged to Older Patients: A Retrospective Study on the Preoperative MRI Injury Patterns and Mid-Term Patient-Reported Outcome Measures." Journal of Personalized Medicine 13, no. 2 (February 18, 2023): 364. http://dx.doi.org/10.3390/jpm13020364.

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(1) Quadriceps tendon rupture (QTR) is a rare pathology, usually occurring in elderly patients with comorbidities, requiring surgical therapy. The aim of this study was to analyze rupture patterns and concomitant injuries using preoperative magnetic resonance imaging (MRI) and to evaluate patient-reported outcome measures. (2) In this retrospective cross-sectional study, 113 patients with QTR were screened and rupture patterns/concomitant injuries (n = 33) were analyzed via MRI. Clinical outcome was assessed in 45 patients using the International Knee Documentation (IKDC) and Lysholm score with a mean follow-up of 7.2 (±5.0) years. (3) The evaluation of preoperative MRIs showed multiple ruptures of subtendons in 67% with concomitant knee injuries in 45%. The most common associated pathology detected using MRI was pre-existing tendinosis (31.2%). Surgical refixation demonstrated good results with a mean post-operative IKDC score of 73.1 (±14.1) and mean Lysholm score of 84.2 (±16.1). Patient characteristics and individual radiologic rupture patterns did not significantly affect the clinical outcome of patients. (4) Acute QTRs are complex injuries with common involvement of multiple subtendons. MRI imaging can be useful for achieving an accurate diagnosis as pre-existing tendinosis as well as concomitant injuries are common, and might be useful for providing an individual surgical strategy and improving outcomes.

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5

Seiler, Christian. "A Climatological Assessment of Intense Extratropical Cyclones from the Potential Vorticity Perspective." Journal of Climate 32, no. 8 (April 8, 2019): 2369–80. http://dx.doi.org/10.1175/jcli-d-18-0461.1.

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Extratropical cyclones (ETCs) are known to intensify due to three vertically interacting positive potential vorticity perturbations that are associated with potential temperature anomalies close to the surface (θB), condensational heating in the lower-level atmosphere (qsat), and stratospheric intrusion in the upper-level atmosphere (qtr). This study presents the first climatological assessment of how much each of these three mechanisms contributes to the intensity of extreme ETCs. Using relative vorticity at 850 hPa as a measure of ETC intensity, results show that in about half of all cases the largest contributions during maximum ETC intensity are associated with qsat (53% of all ETCs), followed by qtr (36%) and θB (11%). The relative frequency of storms that are dominated by qsat is higher 1) during warmer months (61% of all ETCs during warmer months) compared to colder months (50%) and 2) in the Pacific (56% of all ETCs in the Pacific) compared to the Atlantic (46%). The relative frequency of ETCs that are dominated by θB is larger 1) during colder months (13%) compared to warmer months (3%), 2) in the Atlantic (15%) compared to the Pacific (8%), and 3) in western (11%–20%) compared to eastern ocean basins (4%–9%). These findings are based on piecewise potential vorticity inversion conducted for intense ETCs that occurred from 1980 to 2016 in the Northern Hemisphere (3273 events; top 7%). The results may serve as a baseline for evaluating ETC biases and uncertainties in global climate models.

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El-Menyar, Ayman, Ahammed Mekkodathil, Vishwajit Verma, Bianca M. Wahlen, Ruben Peralta, Ibrahim Taha, Suhail Hakim, and Hassan Al-Thani. "Gender Discrepancy in Patients with Traumatic Brain Injury: A Retrospective Study from a Level 1 Trauma Center." BioMed Research International 2022 (August 18, 2022): 1–7. http://dx.doi.org/10.1155/2022/3147340.

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Objectives. The objective of this study is to explore the gender discrepancy in patients with traumatic brain injury (TBI). Methods. A retrospective analysis of Qatar Trauma Registry (QTR) was conducted among patients (age ≥14y) who were hospitalized with TBI. Data were collected and analyzed based on the gender and age. Results. Over 5 years (2014-2019), 9, 309 trauma patients (90% males and 10% females) were admitted to the trauma center. Of these, 1, 620 (17.4%) patients were hospitalized with TBI (94% males and 6% females). Motor vehicle crash was the main mechanism of injury (MOI) in females, and fall from height was predominant among males. Subdural hematoma (SDH) was the more frequent type of TBI in both genders, but it was more prevalent in male patients ≥55 years. Injury severity score, Glasgow coma scale, and head abbreviated injury score were comparable between males and females. The length of stay in the ICU and hospital and mortality were similar in both genders. However, mortality was higher among males ≥55 years when compared to 14-54 years within the same gender (21% vs. 12%, p = 0.002 ). The crude and adjusted odds ratio did not show that gender is a significant predictor of mortality among TBI patients. Conclusions. Although the incidence and MOI of TBI show significant differences between male and female patients, the severity and outcomes are comparable.

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Batista, Luiz Fernando Dias, Madeline E. Rivera, Aaron B. Norris, Jordan Adams, Roberta Cracco, Morgan Jackson, and Luis O. Tedeschi. "44 Effect of Quebracho (Schinopsis balansae) extract inclusion in a high roughage diet upon in vitro gas production." Journal of Animal Science 98, Supplement_2 (November 1, 2020): 53–54. http://dx.doi.org/10.1093/jas/skz397.122.

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Abstract The utilization of natural plant secondary compounds as feed additives in animal nutrition has been extensively studied because of their ability to modify digestive and metabolic functions. Condensed tannin (CT) supplementation can potentially alter ruminal fermentation, and mitigate methane (CH4) emissions. The objective of this study was to determine the effect of quebracho CT extract (QT; Schinopsis balansae) within a roughage-based diet on overall fermentability and CH4 production utilizing the in vitro gas production technique (IVGP). Twenty rumen cannulated steers (227 ± 19 kg) were randomly assigned to four dietary treatments (n=4): QT at 0, 1, 2, and 3% of DM (QT0, QT1, QT2, and QT3). A roughage-based diet containing 88% bermudagrass hay and 12% concentrate was fed daily at 2.1% of shrunk body weight. The animals were adapted to the basal diet for 24-d then introduced to predetermined treatments for 35d. Rumen inoculum was collected weekly from each steer to perform the incubations. Two hundred milligrams of air-dried base diet were incubated for 48-h with a composite rumen inoculum for each treatment over 5 wk. Kinetic analysis of cumulative 48h gas production was performed using Gasfit. Measurements of CH4 were performed via gas chromatography and digested residue was determined post-incubation. Data were analyzed using a random coefficients model. Total gas production was higher for QT0 compared to QT1 and QT3 (P = 0.001), but not different from QT2 (P = 0.554). The fractional rate of gas production was higher for QT2 compared to QT0 (P = 0.011). First and second pool gas production decreased linearly as QT inclusion increased (P = 0.042 and 0.010, respectively). There was no dietary effect in ivNDFD (P = 0.567). However, there was a linear tendency to decrease CH4 production with the addition of QT (P=0.071) likely due to changes in the microbial population.

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Batista, Luiz Fernando Dias, Aaron B. Norris, Jordan Adams, and Luis O. Tedeschi. "286 Effects of Supplementation of Quebracho Extract Supplementation on Ruminal Ph of Growing Beef Steers." Journal of Animal Science 99, Supplement_3 (October 8, 2021): 158–59. http://dx.doi.org/10.1093/jas/skab235.291.

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Abstract Rumen acidosis is a common metabolic disorder occurring when organic acid production exceeds clearance capacity, reducing ruminal pH. Acidosis occurrence has been directly correlated to the ratio of concentrate to forage in the diet. However, the rates of substrate fermentation and acid absorption vary at different locations in the rumen. The objective of this study was to determine the pH in different locations of the rumen using 16 rumenally- cannulated steers (309 ± 43 kg) receiving quebracho extract (QT; Schinopsis balansae) within a grower-type diet [25:75 forage-to-concentrate, dry matter (DM) % basis]. Animals were randomly assigned to one of four dietary treatments (n = 4): QT at 0, 1, 2, and 3% of DM (QT0, QT1, QT2, and QT3). Animals were adapted to the basal diet (QT0) for 12-d before being introduced to predetermined treatments for four weeks, with feed provided twice daily to allow ad libitum intake. Weekly measurements of ruminal fluid pH and redox potential (Eh) were taken four h post-feeding using a portable pH and redox meter probe in four locations of the rumen (cranial sac, ventral sac, dorsal sac, and reticulum). Data were analyzed using a random coefficients model with the pen as a random effect and week as repeated measures. The DM intake was included as a covariate. There was no interaction among diet, location, and week (P ≥ 0.925) on pH. Overall, ruminal pH was lower for QT0 and QT1 compared to QT3 (P < 0.001). Ruminal pH in the cranial sac and reticulum was greater than in the dorsal sac (5.98, 6.03, and 5.87, respectively; P = 0.001). Redox potential was lower for QT0 in week 1 than all other treatments (P = 0.042). This study indicated that pH differs among locations of the rumen regardless of QT supplementation level and days on feed.

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Batista, Luiz Fernando Dias, Aaron B. Norris, Madeline Rivera, Genevieve D’ Souza, Jordan Adams, and Luis O. Tedeschi. "PSIX-29 Effect of quebracho (Schinopsis balansae) extract inclusion in a high roughage diet upon in situ digestion." Journal of Animal Science 97, Supplement_3 (December 2019): 399–400. http://dx.doi.org/10.1093/jas/skz258.796.

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Abstract The objective was to determine the effect of quebracho tannin extract (QT; Schinopsis balansae) within a roughage-based diet upon dry matter and neutral detergent fiber digestibility (DMD and NDFD, respectively). The use of natural plant secondary compounds as a feed additive in animal nutrition has been studied due to their ability to modify digestive and metabolic functions in both ruminants and non-ruminants. Condensed tannin (CT) supplementation has demonstrated potential to mitigate CH4 emissions, but this commonly corresponds with reduced ruminal fiber degradation. However, prolonged supplementation of CT in a roughage-based diet is limited within the literature. Twenty rumen cannulated animals (227 ± 19 kg) were randomly assigned to four dietary treatments (n = 4): QT at 0, 1, 2, and 3% of DM (QT0, QT1, QT2, and QT3). A maintenance-fed diet containing 88% bermudagrass hay and 12% concentrate was offered at 2.1% of shrunk body weight. Steers were adapted to the base diet for 24-d then introduced to predetermined treatments for 35 d. In situ digestibility data were collected weekly over 5 wk. Digestibility estimates were determined using 48-h in situ disappearance of DM and NDF. Data were analyzed using a random coefficients model. There was no difference in DM or NDF intake for dietary treatment (P = 0.66, and P = 0.65, respectively). However, on week 2 QT2 had lower DMD (P = 0.03) and tended to decrease NDFD (P = 0.06) compared to QT1, and QT3. In contrast, there was no observed difference (P = 0.22) in DMD, and NDFD on week 1, 3, 4, 5, and when the 5-wk data were combined. The addition of QT up to 3% DM in a roughage-based diet does not sacrifice DMD and NDFD over time, but it is not clear as to why QT2 affected DMD and NDFD.

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Morencos, Esther, Blanca Romero-Moraleda, Carlo Castagna, and David Casamichana. "Positional Comparisons in the Impact of Fatigue on Movement Patterns in Hockey." International Journal of Sports Physiology and Performance 13, no. 9 (October 1, 2018): 1149–57. http://dx.doi.org/10.1123/ijspp.2017-0506.

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Purpose: To examine the influence of the match period on the movement patterns of hockey players according to their playing positions under the introduction of quarters (QTRs). Methods: Sixteen subelite-level Spanish National League male hockey players participated in the study (age: 25.5 [2.9] y; body mass: 74.6 [5.5] kg). Global positioning system devices were used to monitor players’ running performance during 17 competitive matches (113 match-play profiles). Only players who played for at least 85% of the game were analyzed. Players were placed into 3 position categories: backs, midfielders, and forwards. Results: Moderate to large differences in relative total distance were found between midfielders and both backs and forwards in all QTRs (effect size [ES]: 0.4–1.2). ES for total distance was moderate for midfielders when compared with backs during the first QTR (moderate ES: 0.7). Midfielders and forwards covered more distance (m and m·min−1) in high-velocity zones than backs (ES: 0.6). Acceleration activities (n·min−1) at moderate and high intensities decreased in all groups across QTRs with moderate to very large ES (ES: 0.4–1.4). Relative sprinting distance decreased in backs (ES: 0.8). Backs had fewer repeated-sprint bouts (n and n·min−1) as the game progressed (ES: 1.0). Conclusions: During competitive match play, a degree of positional variation can be observed across QTRs. The relative distance and the number of accelerations and decelerations at moderate and high intensity decreased across QTRs. No between-QTRs differences in high-speed activity were reported.

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Wang, Jing, Chao Wang, Hong Zhang, Yixian Tang, Xuefei Zhang, and Zhengjia Zhang. "Small-Baseline Approach for Monitoring the Freezing and Thawing Deformation of Permafrost on the Beiluhe Basin, Tibetan Plateau Using TerraSAR-X and Sentinel-1 Data." Sensors 20, no. 16 (August 10, 2020): 4464. http://dx.doi.org/10.3390/s20164464.

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The dynamic changes of the thawing and freezing processes of the active layer cause seasonal subsidence and uplift over a large area on the Qinghai–Tibet Plateau due to ongoing climate warming. To analyze and investigate the seasonal freeze–thaw process of the active layer, we employ the new small baseline subset (NSBAS) technique based on a piecewise displacement model, including seasonal deformation, as well as linear and residual deformation trends, to retrieve the surface deformation of the Beiluhe basin. We collect 35 Sentinel-1 images with a 12 days revisit time and 9 TerraSAR-X images with less-than two month revisit time from 2018 to 2019 to analyze the type of the amplitude of seasonal oscillation of different ground targets on the Beiluhe basin in detail. The Sentinel-1 results show that the amplitude of seasonal deformation is between −62.50 mm and 11.50 mm, and the linear deformation rate ranges from −24.50 mm/yr to 5.00 mm/yr (2018–2019) in the study area. The deformation trends in the Qinghai–Tibet Railway (QTR) and Qinghai–Tibet Highway (QTH) regions are stable, ranging from −18.00 mm to 6 mm. The InSAR results of Sentinel-1 and TerraSAR-X data show that seasonal deformation trends are consistent, exhibiting good correlations 0.78 and 0.84, and the seasonal and linear deformation rates of different ground targets are clearly different on the Beiluhe basin. Additionally, there are different time lags between the maximum freezing uplift or thawing subsidence and the maximum or minimum temperature for the different ground target areas. The deformation values of the alpine meadow and floodplain areas are higher compared with the alpine desert and barren areas, and the time lags of the freezing and thawing periods based on the Sentinel-1 results are longest in the alpine desert area, that is, 86 days and 65 days, respectively. Our research has important reference significance for the seasonal dynamic monitoring of different types of seasonal deformation and the extensive investigations of permafrost in Qinghai Tibet Plateau.

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Burin, Mariana M., Eduardo Gomes da Silva, Tito Vanelli, Tahiane Soares, Mariana Pinto Pereira, Liane Daudt, Lucia Silla, and Laura Fogliatto. "Economic Impact of Imatinib Mesylate Withdraw: An Option for Third World Countries?" Blood 126, no. 23 (December 3, 2015): 5161. http://dx.doi.org/10.1182/blood.v126.23.5161.5161.

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Abstract Introduction: The advent of tyrosine kinase inhibitors has changed the natural history of chronic myelogenous leukemia (CML), promoting molecular remission in a high number of patients. In 40-60% of the patients that reach deep molecular responses (RM4.5 or more) and are using imatinib mesylate for 24 months or longer, a molecular response can be maintained after the cessation of the drug. Besides improving life quality in those patients, to withdraw the medication could have a great economic impact in the health system, what is extremely important in third world countries. Objective: To estimate the economic impact of stopping imatinib mesylate in CML chronic phase patients, receiving treatment for at least 36 months and presenting deep molecular response, determinate by BCR-ABL transcripts with quantitative reverse transcriptase polymerase chain reaction (QRT-PCR), in the last 24 months. Patients and methods: A single center observational retrospective study, including all patients diagnosed with chronic phase CML, confirmed by cytogenetic or molecular exams receiving treatment at a tertiary hospital in Brazil. All patients received imatinib mesylate either in first or second line therapy. Patients presenting deep molecular response for at least 24 months, under imatinib mesylate for 36 months or more were considered eligible for discontinuation the drug. The annual coast with the treatment was estimated considering the coasts of the medication and the QRT-PCR molecular exams in the Brazilian public health system. Results: In this study, 169 patients date were analyzed, the median follow up time is 5 years (range 1-13 years), 26 (15%) of those patients are eligible for stopping imatinib mesylate according to the criteria previously mentioned. Considering the requirement of QRT-PCR exams every month in the first year of discotinuating the drug, these patients would coast proximally 1.550,00 dollars/ patients year for the public health system. This coast could be reduced to 800,00 and 520 dollars/patients year, after the second and third year of the medication withdraw, when monitoring molecular response can be done every 2 and 3 months respectively. The patients receiving imatinib mesylate, and having QTR-PCR exams every six months, in the other hand, would coast the Brazilian public health system over 31.000, 00dollars /patients year. Stopping imatinib mesylate could reduce CML chronic phase treatment coasts in up to 95%. Discussion: Discontinuating imatinib mesylate is something that must be done only in clinical trial. The economic impact projection shown in this study observed the eligibility criteria described in the literature. If stopping imatinib mesylate proves to be a safe option, studies promoting it should be done in Brazil and other third world countries, as a manner of saving resources in the health system. Furthermore, the impact in life quality free of adverse effects and the possibility of gestation in young woman is not to be ignored. Disclosures No relevant conflicts of interest to declare.

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Youssef, Omneya I., and Samar M. Farid. "QTc and QTd in Children with Type 1 Diabetes Mellitus during Diabetic Ketoacidosis." ISRN Pediatrics 2012 (November 6, 2012): 1–4. http://dx.doi.org/10.5402/2012/619107.

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Cardiac arrest has been described in children with diabetic ketoacidosis (DKA). Aim. To evaluate QTc and QTd in type 1 diabetic children with DKA. Methods. Twelve-lead ECG was done to 30 type 1 diabetic children with DKA at presentation and recovery. Corrected QT interval and QT dispersion (QTd) were assessed. Results. QTc and QTd mean values were significantly decreased in patients after than before DKA recovery (P<0.01). Procedure. Sixteen patients (53, 3%) had prolonged QTc during DKA (range 451–538 ms) that dropped to one patient after recovery, his QTc (453 ms) returned to normal 5 days after hospital discharge. Nineteen patients (63.3%) had prolonged QTd (>50 ms) that dropped to three after recovery. The fact that three patients had normal QTc but prolonged QTd increases the privilege of QTd over QTc as a better marker for cardiac risk in those patients. Anion gap was significantly associated with QTc and QTd prolongation (P<0.0001). Patients had no electrolyte abnormalities or hypoglycemia to account for QTc or QTd prolongation. Conclusion. Prolonged QTc and QTd frequently occur in DKA positively correlated to ketosis. Cardiac monitoring for patients with DKA is mandatory.

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Dao, Sylvia H., Jamie M. Heffernan, Andrew Greenway, Kaitlyn M. Libraro, Deirdre Twohig, and Jim Gallagher. "581 Sustained Multidisciplinary CLABSI Bundle in the Burn Center." Journal of Burn Care & Research 43, Supplement_1 (March 23, 2022): S127. http://dx.doi.org/10.1093/jbcr/irac012.209.

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Abstract Introduction Central line-associated bloodstream infections (CLABSI) remains a high risk for burn patients due to their compromised integumentary system. Additionally, identifying bloodstream infections secondary to a burn infection versus a central line remains a challenge. Literature review suggests multidisciplinary CLABSI bundles (MCB) demonstrate reduction of CLABSIs. This research looks at the use of a MCB compared to the application of the standard CLABSI bundle alone reduce CLABSI incidence and standardized infection ratios over the past two years in the Burn Center. We hypothesize a MCB will have sustained CLABSI SIR and incidence reduction over time. Methods Infection Prevention & Control CLABSI data collection on all burn patients pre-intervention (2017-2018) and post-intervention (2019-2020) were performed as a quality improvement project; IRB was not obtained. In addition to the CLABSI Bundle (optimal site, aseptic insertion, aseptic maintenance, timely removal, & education), MCB was also implemented in Qtr. 1, 2019. MCB includes necessity of line discussion during daily and multidisciplinary rounds, strategic blood culture collection upon admission/transfers for patients with existing central line, improved nursing and provider documentation of burn infection per CDC definitions, integration of CLABSI reviews in tiered Burn Quality Improvement Program, and universal zero CLABSI goal setting for RNs. Two-sample t-test will be used to compare results pre-intervention (2017-18) & post-intervention (2019-20). CLABSI incidence and standardized Infection ratio will be illustrated per year. Results The post-intervention CLABSI SIR data (M= 0.08, SD=0.11) significantly improved when compared to the pre-intervention CLABSI SIR data (M= 0.77, SD= 0.169), t(2)=4.72, p=0.02. The post-intervention CLABSI incidence data (M=0.5, SD=0.70) significantly improved when compared to the pre-intervention CLABSI incidence data (M=4.5, SD= 0.70), t(2)= 5.65, p= 0.01 Conclusions The combination of the CLABSI bundle with the MCB demonstrated favorable CLABSI SIR and incidence reduction, as literature suggests. Implementing multimodal, multidisciplinary interventions must be a priority for sustained CLABSI reduction. Considerations for future studies should measure length of catheter days, incidence of positive blood cultures on admission/transfers for patients with existing central lines, and incidence of burn infection rates with positive blood culture and an existing central line.

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Arshad, Nimra, Haris Abdul Rehman, Hafiz Khawar, Muhammad Umar, Rabia ,. Khurshid, Misbah Faiz, Aqsa Qurban, Kanza Batool, Hafiza Rumesa Yaqoob, and Dania Azeem. "Identification of Antibacterial Efficacy of Cb6 (E)-1-(4-fluorophenyl)-3-Phenylprop-2-en-1-one against Escherichia Coli." Pakistan Journal of Medical and Health Sciences 16, no. 9 (September 30, 2022): 764–68. http://dx.doi.org/10.53350/pjmhs22169764.

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Objective of the study: Escherichia coli bacteria with increased antibiotic resistance represent a serious threat to public health. The aim of this study was to assess Cb6 (E)-1-& effectiveness against microorganisms (4-fluorophenyl), determine the effectiveness of Cb6 (E)-1-(4-fluorophenyl)-3-phenyl prop-2-en-1-one against anti-fungal agents and -3 -phenylprop-2-en-1-one against E. coli (Curvularia). StudyDesign:Study was designed by sample collection, culturing, biochemical tests, sensitivity assay and qRT-PCR. Place and Duration: The prospective study was carried out at the University of Agriculture in Faisalabad, Pakistan from 1st February 2019 to 18th June 2019. Methodology: Through horizontal and vertical gene transfer, Escherichia coli acquired resistance genes and developed resistance against many antibiotic classes. The following genes were examined in the current study in E. coli: Van B, ermC, Iva-A, Qnr-A, Qnr-B, tet M, tet O, and tet W resistance genes. To assess the effectiveness of the antibacterial and antifungal agents, antibiotic sensitivity testing was carried out. Results: E.coli chalcone resistance genes, have displayed highly significant (P 0.0001) expression in the patient sample when compared to the control. Conclusion: It was concluded that the chalcones are highly resistant to E coli in prediction. Van B, erm C, Iva-A, Qnr-A, Qnr-B, tet M, tet O, and tet Ware resistant genes of the Escherichia coli against the Cb6 (E)-1-(4-fluorophenyl)-3 -phenyl prop-2-en-1-one and it was showed the high expression level. Keywords: Chalcones Resistant gene, Antibacterial action, Antibiotic sensitivity, Expression.

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16

Arends, Danny, Pjotr Prins, Ritsert C. Jansen, and Karl W. Broman. "R/qtl: high-throughput multiple QTL mapping: Fig. 1." Bioinformatics 26, no. 23 (October 21, 2010): 2990–92. http://dx.doi.org/10.1093/bioinformatics/btq565.

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Santos, Brenna Braga dos. "Quercetina na Prevenção do Processo Erosivo de Origem Intrínseca: Estudo in Vitro." Brazilian Journal of Case Reports 3, Suppl.7 (July 7, 2023): 9. http://dx.doi.org/10.52600/2763-583x.bjcr.2023.3.suppl.7.9.

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O objetivo do presente estudo foi de avaliar a ação da QT como uma medida protetora na dentina erosivamente desmineralizada em três dias de erosão cíclica. Blocos de dentina humana radicular foram divididos aleatoriamente em três grupos (n = 13), de acordo com o tratamento de dentina submetida ao desafio com ácido clorídrico: água destilada (AD), e QT 10% em aplicações de 1 minuto (QT1) e 5 minutos de aplicação de QT (QT5). Foram realizados procedimentos cíclicos repetidos durante um período de três dias, incluindo formação de película, erosão, tratamentos com soluções testes (AD, QT1 e QT5) e remineralização com saliva artificial. Após a formação da película, cada bloco foi submetido a uma solução de ácido clorídrico por 60 segundos. Cada espécime foi então lavado com água destilada e tratado com a solução de tratamento em seus respectivos tempos, e então, os espécimes foram imersos em saliva artificial por 1 hora, realizado sob agitação a 100 rpm a 37 ° C. Este ciclo foi repetido três vezes por dia durante três dias. A variável dependente avaliada foi o desgaste dentário, a través do uso do perfilômetro de contato Hommel Tester T1000. A média e desvio padrão por grupo foram calculados e os procedimentos estatísticos foram realizados utilizando o pacote estatístico SPSS 17.0 para Windows. O teste de Kolmogorov Smirnov foi aplicado a todos os grupos para verificar a distribuição normal dos erros. Como os valores foram rotineiramente distribuídos por todos os grupos, ANOVA e o teste de Tukey foram usados para fins comparativos. O nível de significância foi estabelecido em 5%. Para o desgaste dental, e houve diferença estatisticamente significante entre os grupos testados. Logo, o composto ativo interferiu na perda do desgaste, em que QT1 e QT5 foram semelhantes entre si, e ambas estatisticamente diferente ao grupo controle AD. A QT é uma promissora alternativa na prevenção do processo erosivo.

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18

Byrne, Patrick F. "Quantitative Trait Locus (QTL) Analysis 1." Journal of Natural Resources and Life Sciences Education 34, no. 1 (2005): 124. http://dx.doi.org/10.2134/jnrlse.2005.0124.

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19

McGarry, Bryony L., Harriet J. Rogers, Michael J. Knight, Kimmo T. Jokivarsi, Olli H. J. Gröhn, and Risto A. Kauppinen. "Determining Stroke Onset Time Using Quantitative MRI: High Accuracy, Sensitivity and Specificity Obtained from Magnetic Resonance Relaxation Times." Cerebrovascular Diseases Extra 6, no. 2 (August 26, 2016): 60–65. http://dx.doi.org/10.1159/000448814.

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Many ischaemic stroke patients are ineligible for thrombolytic therapy due to unknown onset time. Quantitative MRI (qMRI) is a potential surrogate for stroke timing. Rats were subjected to permanent middle cerebral artery occlusion and qMRI parameters including hemispheric differences in apparent diffusion coefficient, T2-weighted signal intensities, T1 and T2 relaxation times (qT1, qT2) and f1, f2 and Voverlap were measured at hourly intervals at 4.7 or 9.4 T. Accuracy and sensitivity for identifying strokes scanned within and beyond 3 h of onset was determined. Accuracy for Voverlap, f2 and qT2 (>90%) was significantly higher than other parameters. At a specificity of 1, sensitivity was highest for Voverlap (0.90) and f2 (0.80), indicating promise of these qMRI indices in the clinical assessment of stroke onset time.

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20

Ulm, Sean, Melissa Carter, Jill Reid, and Ian Lilley. "Eurimbula Site 1, Curtis Coast: Site Report." Queensland Archaeological Research 11 (December 1, 1999): 105. http://dx.doi.org/10.25120/qar.11.1999.89.

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This site report presents an account of archaeological excavations undertaken at Eurimbula Site 1, a large open midden site complex located in Eurimbula National Park on the southern Curtis Coast, Central Queensland. Excavations yielded a cultural assemblage dominated by mud ark (Anadara trapezia) and commercial oyster (Saccostrea commercialis) and incorporating small quantities of stone artefacts, fish bone and charcoal. Densities of cultural material were found to decrease markedly with distance from the creek. Analyses of excavated material demonstrate extensive low intensity use of the site from at least c.3,200 cal BP to the historical period.

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21

Prangnell, Jonathan. "The Archaeology of the Peel Island Lazaret: Part 1: Survey." Queensland Archaeological Research 13 (December 1, 2002): 31. http://dx.doi.org/10.25120/qar.13.2002.66.

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<p>An archaeological survey on Peel Island in Moreton Bay, southeast Queensland, was conducted to assist the conservation planning for the Peel Island Lazaret (PIL), one of a number of institutions housed on the island during the nineteenth and twentieth centuries. The survey revealed a patterning of artefacts across the island as well as landscape modification related to its Aboriginal and European institutional uses.</p>

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22

Suys, Bert E., Sophie J. A. Huybrechts, Daniel De Wolf, Lieve Op De Beeck, Dirk Matthys, B. Van Overmeire, Marc V. L. Du Caju, and Raoul P. A. Rooman. "QTc interval prolongation and QTc dispersion in children and adolescents with type 1 diabetes." Journal of Pediatrics 141, no. 1 (July 2002): 59–63. http://dx.doi.org/10.1067/mpd.2002.125175.

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23

Peni Rustami, Yuaftika. "PENINGKATAN PEMBELAJARAN MENULIS RESENSI DENGAN METODE DUTA DJARUM QRR PADA SISWA KELAS XI IPS 1 DI SMAN 1 KARAS TAHUN PELAJARAN 2019/2020." ETNOLINGUAL 6, no. 1 (September 1, 2022): 14–39. http://dx.doi.org/10.20473/etno.v6i1.36727.

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Faktor penyebab rendahnya kemampuan menulis siswa meliputi faktor internal dan eksternal. Faktor penyebab internal adalah siswa cenderung kurang dapat berimajinasi, mengungkapkan ide, dan kemudian menuangkan kata ke dalam bentuk tulisan, siswa belum mampu merangkai kata-kata menjadi kalimat dan menyusunnya ke dalam tulisan yang utuh, serta siswa juga kurang memperhatikan ejaan dan tanda baca dalam menulis. Tujuan dari penelitian ini adalah (1) memaparkan penerapan metode Duta Djarum QRR dalam menulis resensi pada siswa kelas XI IPS 1 di SMAN 1 Karas tahun pelajaran 2019/2020. (2) Mendeskripsikan hasil belajar menulis resensi pada siswa kelas XI IPS 1 di SMAN 1 Karas tahun pelajaran 2019/2020 dengan menggunakan metode Duta Djarum QRR. Metode Duta Djarum QRR merupakan singkatan dari dua tamu dua jaga rumah question read recite. Metode pembelajaran ini merupakan metode pembelajaran modifikasi dari metode TS-TS (two stay-two stray) dengan metode membaca SQ3R (survey, question, read, recite, review). Yang membedakan metode TS-TS dengan Duta Djarum ini adalah adanya setingan membaca QRR (Question Read Recite) pada saat pembelajaran. Di mana QRR sendiri merupakan bagian dari metode membaca SQ3R. Hasil belajar Bahasa Indonesia siswa mengalami peningkatan setelah menggunakan metode pembelajaran Duta Djarum QRR. Hal itu dapat ditunjukkan dari nilai rata-rata hasil LKS yang mengalami peningkatan yaitu dari nilai 76,57 pada siklus I menjadi 85,44 pada siklus II. Metode pembelajaran Duta Djarum QRR juga dapat meningkatkan keaktifan siswa pada pembelajaran Bahasa Indonesia dengan materi menulis resensi. Kata Kunci: Menulis Resensi, Duta Djarum QRR

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24

Kalatsei, L. V., and V. A. Snezhitskiy. "LONG QT SYNDROME. PART 1." Journal of the Grodno State Medical University 16, no. 4 (2018): 388–93. http://dx.doi.org/10.25298/2221-8785-2018-16-4-388-393.

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25

Hooley, C. "On polynomials that are sums of two perfect qth powers." Acta Arithmetica 145, no. 1 (2010): 1–31. http://dx.doi.org/10.4064/aa145-1-1.

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26

CORDERO, PATRICIO, ERIC GOLES, and GONZALO HERNANDEZ. "Q2R+Q2R AS A UNIVERSAL BILLIARD." International Journal of Modern Physics C 03, no. 02 (April 1992): 251–66. http://dx.doi.org/10.1142/s012918319200021x.

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In this work we study the computing capabilities as well as some dynamical properties of an automaton called M4R. This automaton corresponds to the mixing of the energy profiles of two independent copies of the Q2R automaton with frustrations. We associate to each copy of a Q2R an equivalent automaton M2R, which, with the Margoluos neighborhood, exhibits the local changes of the Q2R energy.1 By doing so we generalize the dynamics by upgrading M2R according to four partitions of the lattice. This new dynamics — called M4R — is based on a local rule which corresponds to the local energy change of two independent copies of Q2R. The M4R model is reversible and conservative (magnetization is constant in time) and it has properties of a discrete billiard (as some of the hydrodynamics discrete versions of Navier-Stokes models). Moreover, this automaton has powerful computing capabilities. In fact, by using some special configurations of M4R, we exhibit universal gates and register that allow us to code any algorithm.

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27

Shwe, M. A., D. E. Heckerman, M. Henrion, E. J. Horvitz, H. P. Lehmann, G. F. Cooper, and B. Middleton. "Probabilistic Diagnosis Using a Reformulation of the INTERNIST-1/QMR Knowledge Base." Methods of Information in Medicine 30, no. 04 (1991): 241–55. http://dx.doi.org/10.1055/s-0038-1634846.

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Abstract:In Part I of this two-part series, we report the design of a probabilistic reformulation of the Quick Medical Reference (QMR) diagnostic decision-support tool. We describe a two-level multiply connected belief-network representation of the QMR knowledge base of internal medicine. In the belief-network representation of the QMR knowledge base, we use probabilities derived from the QMR disease profiles, from QMR imports of findings, and from National Center for Health Statistics hospital-discharge statistics.We use a stochastic simulation algorithm for inference on the belief network. This algorithm computes estimates of the posterior marginal probabilities of diseases given a set of findings. In Part II of the series, we compare the performance of QMR to that of our probabilistic system on cases abstracted from continuing medical education materials from Scientific American Medicine. In addition, we analyze empirically several components of the probabilistic model and simulation algorithm.

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28

Barker, Bryce. "Nara Inlet 1: a Holocene sequence from the Whitsunday Islands, central Queensland coast." Queensland Archaeological Research 6 (January 1, 1989): 53–76. http://dx.doi.org/10.25120/qar.6.1989.137.

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This paper reports an archaeological excavation at Nara Inlet, Hook Island, one of the Whitsunday group off the central Queensland coast. The site, Nara Inlet 1, is a large rockshelter which returned a non-basal 14C date of 8150±80 bp. The excavation forms part of a wider study investigating prehistoric island use by Aborigines of the Whitsunday region as well as archaeological change in the Holocene Period.

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29

Daniele, Aurora, Fiorella Altruda, Marina Ferrone, Lorenzo Silengo, Giovanni Romeo, Nicoletta Archidiacond, and Mariano Rocchi. "Mapping of Human Hexokinase 1 Gene to10q11→qter." Human Heredity 42, no. 2 (1992): 107–10. http://dx.doi.org/10.1159/000154049.

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30

Beeckmann, P., J. Schroffel, G. Moser, H. Bartenschlager, G. Reiner, and H. Geldermann. "Linkage and QTL mapping for Sus scrofa chromosome 1." Journal of Animal Breeding and Genetics 120, s1 (December 2003): 1–10. http://dx.doi.org/10.1046/j.0931-2668.2003.00418.x.

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31

Shwe, A. M., E. D. Heckerman, M. Henrion, J. E. Horvitz, P. H. Lehmann, F. G. Cooper, and B. Middleton. "Probabilistic Diagnosis Using a Reformulation of the INTERNIST-1/QMR Knowledge Base." Methods of Information in Medicine 30, no. 04 (1991): 256–67. http://dx.doi.org/10.1055/s-0038-1634847.

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Анотація:

AbstractWe have developed a probabilistic reformulation of the Quick Medical Reference (QMR) system. In Part I of this two-part series, we described a two-level, multiply connected belief-network representation of the QMR knowledge base and a simulation algorithm to perform probabilistic inference on the reformulated knowledge base. In Part II of this series, we report on an evaluation of the probabilistic QMR, in which we compare the performance of QMR to that of our probabilistic system on cases abstracted from continuing medical education materials from Scientific American Medicine. In addition, we analyze empirically several components of the probabilistic model and simulation algorithm.

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32

Armas Cayarga, Anny, Yenitse Perea Hernández, Yaimé J. González González, Santiago Dueñas Carrera, Idania González Pérez, and René Robaina Álvarez. "Generation of HIV-1 and Internal Control Transcripts as Standards for an In-House Quantitative Competitive RT-PCR Assay to Determine HIV-1 Viral Load." Biotechnology Research International 2011 (2011): 1–10. http://dx.doi.org/10.4061/2011/964831.

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Human immunodeficiency virus type-1 (HIV-1) viral load is useful for monitoring disease progression in HIV-infected individuals. We generated RNA standards of HIV-1 and internal control (IC) byin vitrotranscription and evaluated its performance in a quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay. HIV-1 and IC standards were obtained at high RNA concentrations, without DNA contamination. When these transcripts were included as standards in a qRT-PCR assay, it was obtained a good accuracy ( log10unit of the expected results) in the quantification of the HIV-1 RNA international standard and controls. The lower limit detection achieved using these standards was 511.0 IU/mL. A high correlation () was obtained between the in-house qRT-PCR assay and the NucliSens easyQ HIV-1 test (bioMerieux) for HIV-1 RNA quantitation with clinical samples (). HIV-1 and IC RNA transcripts, generated in this study, proved to be useful as standards in an in-house qRT-PCR assay for determination of HIV-1 viral load.

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33

Seknewna, Lema Logamou, Peter Mwita Nyamuhanga, and Benjamin Kyalo Muema. "Smoothed Conditional Scale Function Estimation in AR(1)-ARCH(1) Processes." Journal of Probability and Statistics 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/4816716.

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The estimation of the Smoothed Conditional Scale Function for time series was taken out under the conditional heteroscedastic innovations by imitating the kernel smoothing in nonparametric QAR-QARCH scheme. The estimation was taken out based on the quantile regression methodology proposed by Koenker and Bassett. And the proof of the asymptotic properties of the Conditional Scale Function estimator for this type of process was given and its consistency was shown.

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McNiven, Ian J., Ian Thomas, and Ugo Zoppi. "Fraser Island Archaeological Project (FIAP): Background, Aims and Preliminary Results of Excavations at Waddy Point 1 Rockshelter." Queensland Archaeological Research 13 (December 1, 2002): 1. http://dx.doi.org/10.25120/qar.13.2002.64.

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<p>Coastal southeast Queensland is one of the most intensively studied archaeological regions of Australia. While the Fraser Island World Heritage Area is the most famous landscape in this coastal region, no archaeological excavations have been undertaken and its ancient Aboriginal past remains poorly understood. The Fraser Island Archaeological Project (FIAP) redresses this situation. Excavations at Waddy Point 1 Rockshelter (WP1) in July/August 2001 reveal a focus on local resources (shellfish, fish and tool stone) in the last c.900 years. This finding is consistent with McNiven's (1999) regionalisation model which posits marine resource intensification and the development of separate residential groups occupying the dune systems of Cooloola and Fraser Island in the last 1,000 years. Further excavation will be required to define the base of the cultural deposit of WP1, which may be early Holocene given arrival of the sea off the headland c.10,000 years ago.</p>

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Zheng, Mingmin, Tian Yang, Xiaowei Liu, Guihua Lü, Peng Zhang, Bin Jiang, Shufeng Zhou, et al. "qRf8-1, a Novel QTL for the Fertility Restoration of Maize CMS-C Identified by QTL-seq." G3: Genes|Genomes|Genetics 10, no. 7 (May 29, 2020): 2457–64. http://dx.doi.org/10.1534/g3.120.401192.

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C-type cytoplasmic male sterility (CMS-C), one of the three major CMS types in maize, has a promising application prospect in hybrid seed production. However, the complex genetic mechanism underlying the fertility restoration of CMS-C remains poorly understood. The maize inbred line A619 is one of the rare strong restorer lines carrying the restorer gene Rf4, but different fertility segregation ratios are found in several F2 populations derived from crosses between isocytoplasmic allonucleus CMS-C lines and A619. In the present study, the segregation ratios of fertile to sterile plants in the (CHuangzaosi × A619) F2 and BC1F1 populations (36.77:1 and 2.36:1, respectively) did not follow a typical monogenic model of inheritance, which suggested that some F2 and BC1F1 plants displayed restored fertility even without Rf4. To determine the hidden locus affecting fertility restoration, next-generation sequencing-based QTL-seq was performed with two specific extreme bulks consisting of 30 fertile and 30 sterile rf4rf4 individuals from the F2 population. A major QTL related to fertility restoration, designated qRf8-1, was detected on the long arm of chromosome 8 in A619. Subsequently, qRf8-1 was further validated and narrowed down to a 17.93-Mb genomic interval by insertion and deletion (InDel) and simple sequence repeat (SSR) marker-based traditional QTL mapping, explaining 12.59% (LOD = 25.06) of the phenotypic variation. Thus, using genetic analyses and molecular markers, we revealed another fertility restoration system acting in parallel with Rf4 in A619 that could rescue the male sterility of CHuangzaosi. This study not only expands the original fertility restoration system but also provides valuable insights into the complex genetic mechanisms underlying the fertility restoration of CMS-C.

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36

Vogel, Heike, Dirk Montag, Timo Kanzleiter, Wenke Jonas, Daniela Matzke, Stephan Scherneck, Alexandra Chadt, et al. "An Interval of the Obesity QTL Nob3.38 within a QTL Hotspot on Chromosome 1 Modulates Behavioral Phenotypes." PLoS ONE 8, no. 1 (January 4, 2013): e53025. http://dx.doi.org/10.1371/journal.pone.0053025.

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Leermakers, Daan, and Boris Skoric. "Quantum Alice and silent Bob: Qubit-based Quantum Key Recycling with almost no classical communication." Quantum Information and Computation 21, no. 1&2 (February 2021): 0001–18. http://dx.doi.org/10.26421/qic21.1-2-1.

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We answer an open question about Quantum Key Recycling (QKR): Is it possible to put the message entirely in the qubits without increasing the number of qubits compared to existing QKR schemes? We show that this is indeed possible. We introduce a prepare-and-measure QKR protocol where the communication from Alice to Bob consists entirely of qubits. As usual, Bob responds with an authenticated one-bit accept/reject classical message. Compared to Quantum Key Distribution (QKD), QKR has reduced round complexity. Compared to previous qubit-based QKR protocols, our scheme has far less classical communication. We provide a security proof in the universal composability framework and find that the communication rate is asymptotically the same as for QKD with one-way postprocessing.

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38

&NA;. "Metoprolol reduces the QTc interval* but does not change QTc dispersion in patients with type 1 diabetes mellitus,." Inpharma Weekly &NA;, no. 1452 (August 2004): 15. http://dx.doi.org/10.2165/00128413-200414520-00037.

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39

Ramani, A., B. Grammaticos, and R. Willox. "Generalized QRT mappings with periodic coefficients." Nonlinearity 24, no. 1 (November 25, 2010): 113–26. http://dx.doi.org/10.1088/0951-7715/24/1/006.

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40

Kassotakis, Pavlos, and Nalini Joshi. "Integrable Non-QRT Mappings of the Plane." Letters in Mathematical Physics 91, no. 1 (November 17, 2009): 71–81. http://dx.doi.org/10.1007/s11005-009-0360-1.

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41

Maharijaya, Awang, Ben Vosman, Greet Steenhuis-Broers, Koen Pelgrom, Agus Purwito, Richard G. F. Visser, and Roeland E. Voorrips. "QTL mapping of thrips resistance in pepper." Theoretical and Applied Genetics 128, no. 10 (July 8, 2015): 1945–56. http://dx.doi.org/10.1007/s00122-015-2558-1.

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42

Pu, Jeffrey J., Shasha Lu, Matthew Nemesure, Emmanuel Kwame Teye, Emily Schleicher, George-Lucian Moldovan, Robert A. Brodsky, and Fangyuan Chen. "PIG-a Gene Expression Deficiency Association with Reduced DNA Damage Checkpoint Response and Activation." Blood 132, Supplement 1 (November 29, 2018): 3875. http://dx.doi.org/10.1182/blood-2018-99-119177.

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Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disease caused by mutation in the PIG-A gene. When expressed, it encodes a protein that is crucial in glycophosphatidylinositol (GPI) anchor biosynthesis. The mutation of this gene causes plasma membrane GPI anchor biosynthesis deficiency, cell membrane structure alteration, signal transduction pathway blockage and vulnerability to complement complex attack. Despite these deficiencies, PNH cells have a clonal advantage and this dominant expansion is the hallmark of PNH progression. The mechanism of this growth, however, is still unknown. Recently, multiple studies demonstrated that malignant cells harboring the PIG-A mutation appear to have a higher degree of genomic instability and disease progression. This led to the proposal of using the PIG-A gene mutation frequency as the biomarker of mutagenesis to evaluate the transgenic animal mutation or mutagenicity of test compounds. The PIG-A gene mutation assay is even considered as a valuable tool for quantifying mutational events in vivo and in vitro despite the mechanism remaining unknown. This study investigated the impacts PIG-A mutation in genomic stability, DNA damage response, and DNA damage checkpoint activity, which as a measure of cellular stability as well as a possible mechanism for clonal expansion. Methods: To investigate the relationship between PIG-A gene mutation status and DNA damage checkpoint activity we looked at 45 high-risk MDS/AML patients, 3 classic PNH patients and 12 healthy controls. Additionally, the TF-1 leukemia cell line was used to evaluate PIG-A wild-type vs PIG-A CRISPR knockout vs PIG-A siRNA transient suppression. H2AX/ɣH2AX, ⍺-pChk1, ⍺-pChk2, ⍺-ubPCNA, and ⍺-pRPA proteins and RNA levels were used as a quantitative indicator of DNA damage repair activity via qTR-PCR and western blot. The comet assay and fiber combing assay were further applied to explore the DNA damage and cellular replication events. RNAseq analysis was used to explore the impact of PIG-A mutation in global gene expression. Results: The in vitro results from the leukemia cell lines with various PIG-A mutation statuses showed that the PIG-A mutation decreases ɣH2AX expression. PIG-A mutation was also associated with down-regulated expression of ⍺-pChk1, ⍺-pChk2, ⍺-ubPCNA, and ⍺-pRPA proteins. The decreased levels of those gene expressions indicate that there is increased genomic stability and less repair activity at the DNA damage response checkpoint. The results of the comet assay support this data with the PIG-A mutated cells exhibiting significantly (p<0.01) shorter tail lengths than the wild-type counterparts. The fiber-combing assay showed a reduced helicase activity for DNA replication in PIG-A mutated cells. In patient samples, subjects with PNH showed significantly lower levels of ɣH2AX expression when compared to both healthy controls and AML/MDS patients. The comet assay revealed that PNH patients had decreased DNA double strand breaks and fiber combing assay showed a reduced DNA repair activity when compared to normal controls and AML patients with intact PIG-A gene expression (p<0.01). Additionally, RNAseq analysis reveals that the expression of 10/10 genes involved in the DNA repair mechanism were down-regulated in PIG-A mutated cells when compared to wild-type control in both cell lines and patient samples. Conclusion: The above-mentioned results showed that there were decreased expressions of both DNA damage response checkpoint genes and repair genes in both the PIG-A CRISPR knockout leukemia cell lines as well as in the PNH patients. PIG-A mutation is globally associated with reduced DNA damage response capability and increased cellular stability. Our finding explains, at least partially, why PIG-A gene mutation status could be seen as a biomarker of mutagenesis and how PNH cells dominantly expend via clonal escape. Disclosures No relevant conflicts of interest to declare.

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43

Taubel, Jorg, Ulrike Lorch, Simon Coates, Dilshat Djumanov, and Georg Ferber. "Concentration-QTc analysis integrated into a Phase 1 Japanese bridging study." Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (2018): PO3–3–29. http://dx.doi.org/10.1254/jpssuppl.wcp2018.0_po3-3-29.

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44

Wirén, Anna, and Per Jensen. "A Growth QTL on Chicken Chromosome 1 Affects Emotionality and Sociality." Behavior Genetics 41, no. 2 (July 2, 2010): 303–11. http://dx.doi.org/10.1007/s10519-010-9377-6.

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45

Fériani, W., S. Rezgui, and M. Cherif. "Detection of QTL and QTL × environment interaction for scald resistance in a two-row × six-row cross of barley." Cereal Research Communications 48, no. 2 (February 27, 2020): 187–93. http://dx.doi.org/10.1007/s42976-020-00024-1.

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46

Khoeru Solihin, Rully, and Muaz Muaz. "THE USE OF QUESTION ANSWER-RELATIONSHIP (QAR) STRATEGY ON IMPROVING STUDENTS’ READING COMPREHENSION AT SMAN 1 JATITUJUH." Journal of English Language Learning 6, no. 1 (June 27, 2022): 115–20. http://dx.doi.org/10.31949/jell.v6i1.2747.

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Abstract. The objectives of this research are to find out whether or not there is a significant of difference between the Reading Comprehension of the Twelfth Grade Students of SMAN 1 Jatitujuh taught before and after using the Question-Answer Relationship (QAR) strategy. The method in this study was quantitative. The subject of this research is students in XII MIPA 1. The research instrument used by the writer is a test (pre-test and post-test) The result of this research, it was found that of the reading comprehension of the twelfth-grade students of SMAN 1 Jatitujuh before being taught by using QAR strategy was sufficient, the mean is 69.71. Meanwhile of the reading comprehension of the twelfth grade students of SMAN 1 Jatitujuh after being taught by QAR strategy was categorized good, the mean is 85. Moreover, the calculation of the t-count, the score is 11.867 was higher than t-table, score is 2.032 (11.867 > 2.032) in level significance 5%. Based on the result above, it could be concluded that Question Answer Relationship (QAR) strategy could improve reading comprehension of the twelfth grade students of SMAN 1 Jatitujuh. In addition, the subjects also responded positively the implementation of QAR strategy.

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Song, Hailong, JianZhen Cai, XueShen Wang, Hui Wang, YanFeng Li, and XiaoDing Huang. "Realization of Graphene-based Quantum Hall Resistance Standard." Journal of Physics: Conference Series 2557, no. 1 (July 1, 2023): 012048. http://dx.doi.org/10.1088/1742-6596/2557/1/012048.

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Abstract Quantum Hall Resistance (QHR) standard replaced the physical resistance standard as a primary standard. Traditional QHR standard needs liquid helium to operate, which limits the application of the QHR standard. A graphene-based QHR standard with G-M cryocooler is realized, which does not need liquid helium and has been in operation continuously with high performance. It can meet extensive needs of accurate measurement of precision resistors and helps to promote the development of traceability flattening.

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Ding, Fan, Youlin Li, and Zhongtao Wu. "Contact (+1)-surgeries along Legendrian two-component links." Quantum Topology 11, no. 2 (June 21, 2020): 295–321. http://dx.doi.org/10.4171/qt/136.

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SHEN, Bo, Jie-yun ZHUANG, Ke-qin ZHANG, Wei-min DAI, Ye LU, Li-qing FU, Jia-ming DING, and Kang-le ZHENG. "QTL Mapping of Chlorophyll Contents in Rice." Agricultural Sciences in China 6, no. 1 (January 2007): 17–24. http://dx.doi.org/10.1016/s1671-2927(07)60012-1.

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Ethaib, Saleem. "Solid Waste Situation in Thi-Qar Governorate." IOP Conference Series: Materials Science and Engineering 584 (August 15, 2019): 012023. http://dx.doi.org/10.1088/1757-899x/584/1/012023.

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