Готові списки джерел за темами / Pyrimidine ring

Добірка наукової літератури з теми "Pyrimidine ring"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 19 лютого 2023

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Статті в журналах з теми "Pyrimidine ring"

1

Verma, Vishal, Chandra Prakash Joshi, Alka Agarwal, Sakshi Soni, and Udichi Kataria. "A Review on Pharmacological Aspects of Pyrimidine Derivatives." Journal of Drug Delivery and Therapeutics 10, no. 5 (September 15, 2020): 358–61. http://dx.doi.org/10.22270/jddt.v10i5.4295.

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Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogens at positions 1 and 3 in the ring. Pyrimidines are typically synthesized by the “Principal Synthesis” involving cyclization of beta-dicarbonyl compounds with N-C-N compounds. Reaction of the former with amidines to give 2-substituted pyrimidines, with urea to give 2-pyrimidiones, and guanidines to give 2-aminopyrimidines are typical. Pyrimidines can be prepared via the biginelli reaction. Many other methods rely on condensation of carbonyls with diamines for instance the synthesis of 2-Thio-6-methyluracil from thiouria and ethyl acetoacetate or the synthesis of 4-methylpyrimidine with 4, 4-dimethoxy-2-butanone and formamide. Pyrimidine derivatives show antimicrobial activity, anticancer activity, anti-inflammatory activity, antidiabetic, and analgesic activity.1. Keywords: Pyrimidine derivatives, Synthesis, derivatives and pharmacological activities.
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2

Wenska, Grazyna, Bohdan Skalski, Stefan Paszyc, and Zofia Gdaniec. "Photochemistry of N-(pyrimidin-2-one-4-yl)pyridinium derivatives. The ring contraction of pyrimidinone into imidazolinone." Canadian Journal of Chemistry 73, no. 12 (December 1, 1995): 2178–84. http://dx.doi.org/10.1139/v95-270.

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Photochemical reactions (λ > 300 nm) of N-(1-methylpyrimidin-2-one)-and N-(1,5-dimethyl-pyrimidin-2-one)pyridinium chlorides were studied in deoxygenated aqueous solution at various pH's. Only the former compound was found to be reactive under these conditions to give pyrimidine ring contraction photoproducts 1-methyl-4-imidazolin-2-one and 1-methyl-4-imidazolin-2-one-5-carboxyaldehyde, with pH-dependent chemical yields. The photochemical pyrimidine ring contraction reaction does not occur for other photochemically reactive pyrimidin-2-ones bearing 3-methylimidazolium-1,1,2,4-triazol-1-yl, or imidazol-1-yl as substituents at the C-4 position. The suggested mechanism of the reaction involves the addition of water to the pyrimidinone part of the N-(1-methylpyrimidin-2-one)pyridinium salt in the excited triplet state as the primary photochemical step. Addition of alcohol to the pyridinium ring was found to be the major reaction under irradiation of N-(1-methylpyrimidin-2-one-4-yl)pyridinium chloride in methanol. Keywords: photochemistry, N-(pyrimidin-2-one-4-yl)pyridinium compounds, pyrimidine ring contraction, 1-substituted-4-imidazolin-2-ones, 4-imidazolin-2-one-5-carboxyaldehydes.
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3

Mohammed, F. K., and M. G. Badrey. "Synthesis of Pyrimidines and Heteroannulated Pyrimidine Ring Systems." Journal of the Korean Chemical Society 55, no. 2 (April 20, 2011): 218–29. http://dx.doi.org/10.5012/jkcs.2011.55.2.218.

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4

Azam, Mohammed Afzal, Loganathan Dharanya, Charu Chandrakant Mehta, and Sumit Sachdeva. "Synthesis and biological evaluation of some novel pyrazolopyrimidines incorporating a benzothiazole ring system." Acta Pharmaceutica 63, no. 1 (March 1, 2013): 19–30. http://dx.doi.org/10.2478/acph-2013-0001.

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In the present study, a series of benzothiazol derivatives 3a-l containing pyrazolo[3,4-d]pyrimidine moiety at the second position were synthesized and characterized by analytical and spectral data. The compounds were tested for their in vitro antimicrobial activity. Compounds 1-(1,3-benzothiazol-2- yl)-3-methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine (3a), 1- (1,3-benzothiazol-2-yl)-4-(4-chlorophenyl)-3-methyl-1H-pyrazolo[ 3,4-d]pyrimidine (3d) and 1-(1,3-benzothiazol-2-yl)- 3-methyl-4-substituted phenyl-1H-pyrazolo[3,4-d]pyrimidines (3h-j) showed significant inhibitory activity against P. aeruginosa whereas compounds 1-(1,3-benzothiazol-2-yl)-4- (2-chlorophenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine (3b), 2-[1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin- 4-yl]phenol (3e), 1-(1,3-benzothiazol-2-yl)-4-(3,4-dimethoxyphenyl)- 3-methyl-1H-pyrazolo[3,4-d]pyrimidine (3h), 4-[1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazolo[3,4-d]pyri midin-4-yl]-N,N-dimethylaniline (3j) and 1-(1,3-benzothiazol- 2-yl)-3-methyl-4-[2-phenylvinyl]-1H-pyrazolo[3,4-d]pyrimidine (3k) were found to be active against C. albicans. Some of these synthesized compounds were evaluated for their in vivo acute toxicity, analgesic, anti-inflammatory, and ulcerogenic actions. The tested compound 4-[1-(1,3-benzothiazol- 2-yl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-N, N-dimethylaniline (3j) exhibited maximum analgesic and anti-inflammatory activities. Compounds 1-(1,3-benzothiazol- -2-yl)-3-methyl-4-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidine (3i) and 3j showed a significant gastrointestinal protection compared to the standard drug diclofenac sodium.
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5

Gallagher, P. E., and N. J. Duker. "Detection of UV purine photoproducts in a defined sequence of human DNA." Molecular and Cellular Biology 6, no. 2 (February 1986): 707–9. http://dx.doi.org/10.1128/mcb.6.2.707-709.1986.

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Анотація:
The UV-irradiated, 3'-end-labeled, 92-base-pair terminus of the human alphoid sequence was incubated with purified endonuclease v. Previously unreported photoproducts were incised at purine loci. These were not pyrimidine photodimers, 6-4'-(pyrimidin-2'-one)-pyrimidines, base loss sites, or ring-opened purines. Therefore, purine-containing photoproducts, possibly dimers, were incised by the enzyme preparation.
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6

Gallagher, P. E., and N. J. Duker. "Detection of UV purine photoproducts in a defined sequence of human DNA." Molecular and Cellular Biology 6, no. 2 (February 1986): 707–9. http://dx.doi.org/10.1128/mcb.6.2.707.

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Анотація:
The UV-irradiated, 3'-end-labeled, 92-base-pair terminus of the human alphoid sequence was incubated with purified endonuclease v. Previously unreported photoproducts were incised at purine loci. These were not pyrimidine photodimers, 6-4'-(pyrimidin-2'-one)-pyrimidines, base loss sites, or ring-opened purines. Therefore, purine-containing photoproducts, possibly dimers, were incised by the enzyme preparation.
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7

Yamuna, Thammarse S., Jerry P. Jasinski, Brian J. Anderson, H. S. Yathirajan, and Manpreet Kaur. "4-Hydroxy-5-(2-methoxyphenoxy)-2,2′-bipyrimidin-6(5H)-one dihydrate." Acta Crystallographica Section E Structure Reports Online 69, no. 11 (October 26, 2013): o1707—o1708. http://dx.doi.org/10.1107/s1600536813028900.

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Анотація:
The title compound, C15H12N4O4·2H2O, crystallizes with two independent water molecules in the asymmetric unit. The dihedral angles between the mean planes of the benzene and pyrimidine rings and that of the pyrimidin-4-one ring are 85.1 (9) and 82.1 (1)°, respectively. The mean plane of the pyrimidine ring is twisted by 12.8 (8)° from that of the pyrimidin-4-one ring. The dihedral angles between the benzene ring and the mean planes of the pyrimidine and pyrimidin-4-one rings are 85.1 (9) and 82.1 (1)°, respectively.In the crystal, N–H...O, O—H...N and O—H...O hydrogen bonds involving both water molecules are present; these link the molecules into a two-dimensional network parallel to (010). In addition, weak C—H...π and π–π [centroid–centroid distance = 3.6183 (8) Å] interactions occur.
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8

Ahmed Elkanzi, Nadia Ali. "Synthesis and Biological Activities of Some Pyrimidine Derivatives: A Review." Oriental Journal Of Chemistry 36, no. 6 (December 30, 2020): 1001–15. http://dx.doi.org/10.13005/ojc/360602.

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Анотація:
Nitrogen containing synthetically and biologically important heterocyclic ring system namely pyrimidine possess both biological and pharmacological activities, and defend as aromatic six heterocyclic with 1and 3 nitrogen atom in ring. Preparation of pyrimidine via different methods offer its importance in fields of medicinal chemistry and Chemistry. Pyrimidines and their derivatives act as anti-inflammatory, anti-malaria, anti-tumor, cardiovascular agents, anti-neoplastic, anti-tubercular, anti- HIV, diuretic ,anti-viral, anti-microbial, ,analgesic .This review give light up on biological and pharmacological activities of pyrimidine nucleus.
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9

Behera, Manoranjan, M. Sambaiah, Poosa Mallesham, K. Shiva Kumar, Yamini Bobde, Prasanta Hota, Satyanarayana Yennam, and Balaram Ghosh. "Tandem Schiff-Base Formation/Heterocyclization: An Approach to the Synthesis of Fused Pyrazolo–Pyrimidine/Isoxazolo-Pyrimidine Hybrids." Synlett 30, no. 05 (February 5, 2019): 586–92. http://dx.doi.org/10.1055/s-0037-1612081.

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A new synthesis of pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines is described. Key steps in the synthesis involve Stille coupling of 4,6-dichloro-2-phenyl-pyrimidine with tributyl(1-ethoxyvinyl)stannane and tandem Schiff-base formation/heterocyclization of 2,6-di-aryl-5-fluoro-4-acetylpyrimidine with hydrazines or ­hydroxylamine to give pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines, respectively. The position of the fluoro group in the ­pyrimidine ring is important for the success of heterocylization reaction.
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10

Huppatz, JL. "Systemic Fungicides. The Synthesis of Pyrazolo[1,5-a]pyrimidine Analogues of Carboxin." Australian Journal of Chemistry 38, no. 1 (1985): 221. http://dx.doi.org/10.1071/ch9850221.

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Анотація:
The synthesis of a series of pyrazolo [1,5-a] pyrimidine derivatives, structural analogues of the systemic fungicide carboxin, is described. A common intermediate incorporating structural features desirable for fungicidal activity, N-phenyl-3(5)-amino-5(3)-methylpyrazole-4- carboxamide (6), was used to prepare pyrazolo [1,5-a] pyrimidines variously substituted in positions 5 and 7 of the ring system. Bromination of N-phenyl-2-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide (8) occurred preferentially in the phenyl ring and the 6-bromo derivative was prepared by bromination of the corresponding 3-ethoxycarbonyl derivative (24). Attempted nitration of the ester (24) resulted in displacement of the ethoxycarbonyl substituent by a nitro group. The simplest pyrazolo [1,5-a] pyrimidine (8) showed a high level of fungicidal acitvity in fungal growth assays of Basidiomycete species, but compounds substituted in the pyrimidine ring were inactive.
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Більше джерел

Дисертації з теми "Pyrimidine ring"

1

Majumdar, Papiya. "Nitrosative guanosine deamination pyrimidine ring opening implications of effects in homogeneous solution as well as ansiotropic environments /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5967.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed Oct. 16, 2007). Vita. Includes bibliographical references.
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2

McIntyre, Neil A. "Synthesis of ring-constrained thiazolylpyrimidines : inhibitors of cyclin-dependent kinases /." St Andrews, 2007. http://hdl.handle.net/10023/353.

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3

McIntyre, Neil A. "Synthesis of ring-constrained thiazolylpyrimidines : inhibitors of cyclin-dependent kinases." Thesis, University of St Andrews, 2006. http://hdl.handle.net/10023/353.

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One current approach in the treatment of cancer is the inhibition of cyclin dependent kinase (CDK) enzymes with small molecules. Here the discovery and development of 2-anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors is described, including details of the design and successful synthesis of novel ring-constrained thiazolylpyrimidines. The structure-activity relationship (SAR) trends exhibited by this constrained thiazolylpyrimidine family of CDK inhibitors are presented and compared with those from an unconstrained series of analogues. One significant finding from this aspect of the project was that ring-constrained thiazolylpyrimidines in general inhibit CDK2-cyclin E with greater potency than the corresponding unconstrained forms. Furthermore, an X-ray crystal structure of 2-methyl-N-[3-nitrophenyl]-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amine, a representative from the constrained thiazolylpyrimidine series, in complex with CDK2-cyclin A is reported; confirming the binding mode within the CDK2 ATP binding pocket. A further assessment of SARs through the synthesis of control compounds and an extended study into the synthesis of N-substituted derivatives is described. The identification of CDK inhibitors that possess a strong selectivity profile across the CDK family is important. For example, the identification of highly CDK4-selective inhibitors should enable researchers to study the biological role of this important enzyme and to enable a block of cell division in the G1 phase. Here synthetic attempts to prepare a potentially CDK4 selective inhibitor compound, namely 5-methyl-N8-[4-(piperazin-1-yl)phenyl]thiazolo[4,5-h]quinazoline-2,8-diamine, are described. This approach was inspired by SAR data published on a structurally related inhibitor, 8-cyclopentyl-5-methyl-2-[4-(piperazin-1-yl)phenylamino]pyrido[2,3-d]pyrimidin-7(8H)-one.
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4

Ferguson, Alexandra. "Synthesis and ring-opening of NH-aziridine-2-carboxylates, and preparation of novel pyrazolo[3,4-d]pyrimidines for kinase-substrate identification." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11074.

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1: The ring-opening of aziridine-2-carboxylates dominates their reactivity, providing diverse, biologically relevant compounds. Less is known about the chemistry of NH-aziridine-2-carboxylates, owing to multi-step preparation, and lack of N-functionality to aid ring-opening. Building on the recent disclosure of an NH-aziridination methodology applicable to enones, the substrate scope was expanded to include enoates. Aziridination provided access to NH-aziridine-2-carboxylates in a single step from readily available starting materials. Treatment of the resulting aziridine-2-carboxylates with nucleophiles proceeded with high regio- and stereoselectivity, providing access to natural and unnatural amino acid derivatives (Scheme 1).[Molecular structure diagrams appear here. To view, please open pdf attachment] Scheme 1: The synthesis and ring-opening of aziridine-2-carboxylates 2: Identification of kinase protein-substrate sets is crucial to further understand cellular processes, but is challenging with known methodology. Previous study had proposed a new methodology, incorporating two known strategies, bump-hole inhibition and photo-affinity labelling. Novel C3-aryl pyrazolo[3,4-d]pyrimidines were designed for the purpose (Fig. 1), although preparation of the compounds had proved challenging, with several key steps in the synthesis of analogues low-yielding and lengthy. A new synthetic route was developed, using hydrazone allylation to establish the α-tertamine functionality of the pyrazolo[3,4-d]pyrimidines. A late-stage oxidative cleavage was used to re-connect with the original synthetic strategy, to provide access to the C3-hydro analogues. Application of the revised route to the synthesis of the target compounds, using an alternative enol ether for C3-aromatic installation, provided access to two novel pyrazolo[3,4-d]pyrimidines for testing. [Molecular structure diagrams appear here. To view, please open pdf attachment] Fig. 1: C3-aryl pyrazolo[3,4-d]pyrimidines
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5

SAKELLARIOU, FARGUES REINE. "Reactivite chimique et photochimique d'alpha -enones dans les milieux organises." Toulouse 3, 1986. http://www.theses.fr/1986TOU30044.

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Dans une premiere partie on determine les zones monophasiques des diagrammes des phases pseudoternaires de plusieurs microemulsions. Dans l'une d'elles l'isophorone remplace l'huile. Ensuite les chapitres ii et iii sont consacres aux reactions de photocycloaddition (a+a, a+b) d'alpha -enones (isophorone, coumarine, dimethylthymine). On montre que les phenomenes observes sont lies aux differentes localisations possibles des substrats, aux mecanismes de reaction et aux structures des milieux. En conclusion, la localisation des reactifs a l'interface permet la combinaison des effets de concentration, d'organisation et de proximite et conduit a des rendements, des regio et des stereoselectivite eleves
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6

Liu, An-Lun, та 劉安倫. "Relative Binding Free Energy Computation of GSK-3β Kinase-Ligand Complexes Using Thermodynamic IntegrationMD Simulation: Compounds with Pyrimidine Ring". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/tfkk8v.

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7

(14010168), Mirta Golic. "The preparation of dienes and dienophiles containing nucleic acid bases." Thesis, 1999. https://figshare.com/articles/thesis/The_preparation_of_dienes_and_dienophiles_containing_nucleic_acid_bases/21397758.

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The work presented in this thesis deals initially with the synthesis of rigid polyalicyclic dienes and dienophiles with pyrimidine moieties inbuilt in a rigid fashion (building BLOCKS). This work has allowed the production of a new class of ribbon molecules with precisely defined size, shape and position of the pyrimidine ring. In the second stage of the project, an assessment of their ability to participate in cycloaddition reactions as pyrimidine building BLOCK* components was investigated.

2,4-Dimethoxy-1,3-diazaanthracene (I) has acted as the pyrimidine transfer reagent for preparing building BLOCKs. The Diels-Alder adducts IV and V (Scheme I), prepared by reaction of I with norbomadiene, are new pyrimidine dienophilic BLOCKs. Both I and 2,4-dichloro-1,3-diazaanthracene (II) were active in photochemical [4π+4π] cycloaddition reactions with cyclopentadiene to form a second class of building BLOCKs VII and VIII (Scheme I). In addition, the photodimerisation of I and II was studied and structures IX-XII assigned on the basis of spectral and X-ray method.

The 2,4-dichloro-photoadduct VIII is of particular importance for this work since it is easily hydrolysed (2M NaOH, 60 °C, overnight) to the corresponding uracil XIII In contrast, thermal adducts IV and V were very difficult to hydrolyse (NaOH fusion) to uracils XIV and XV (Figure I).

The availability of pyrimidine BLOCKs which contain a reactive π-bond, e.g. (IV, V, VII and VIII) has enabled us to employ 3,6-di(2'-pyridyl)-s-tetrazine (XVI) and ACE (Alkene plus Cyclobutene Epoxide) coupling methods to obtain precisely functionalised ribbon molecules in a direct, convergent synthetic strategy.

The synthesis of the bis-pyrimidines by coupling norbornene reagents using 3,6-di(2'-pyridyl)-s-tetrazine is illustrated in Scheme II. In the first step, s-tetrazine XVI was reacted with pyrimidine BLOCK V under basic conditions to generate the dihydropyridazine XVII. This diaza-1,3-diene was reacted with a further equivalent of V under high pressure conditions to yield the bis-pyrimidines XVIII and XIX, which were separated by radial chromatography. The same procedure was used to link pyrimiclines to other effectors by using alternative alkenes in the second step.

The ACE coupling protocol is illustrated by the reaction of alkene VIII with the dimethoxynaphthalene-containing epoxide XX (Scheme III). The reaction can be conducted under thermal or photochemical conditions and is considered to proceed via 1,3-dipolar intermediate formed by ring-opening of the epoxide C-C bond of XX (See Chapter 4).

Each class of coupled adduct could be hydrolysed to the corresponding uracil by using either acid (XXII) or base (XXIII) hydrolysis conditions, the choice depending on the structure of the molecule in question and its substituents.

The work presented in this thesis involves a deal of new work and has been instrumental in the development of the Lego®-based BLOCK assembly protocol for ribbon molecules construction.

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Книги з теми "Pyrimidine ring"

1

Nishikawa, Michihiro. Photofunctionalization of Molecular Switch Based on Pyrimidine Ring Rotation in Copper Complexes. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54625-2.

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2

Photofunctionalization Of Molecular Switch Based On Pyrimidine Ring Rotation In Copper Complexes. Springer Verlag, Japan, 2014.

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3

Nishikawa, Michihiro. Photofunctionalization of Molecular Switch Based on Pyrimidine Ring Rotation in Copper Complexes. Springer, 2016.

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4

Nishikawa, Michihiro. Photofunctionalization of Molecular Switch Based on Pyrimidine Ring Rotation in Copper Complexes. Springer London, Limited, 2013.

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5

Parker, Philip M. The World Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Pyrimidine Ring, Piperazine Ring, or Unfused Triazine Ring, ... and Salts: A 2007 Global Trade Perspective. ICON Group International, Inc., 2006.

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6

The World Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Pyrimidine Ring, Piperazine Ring, or Unfused Triazine Ring, ... and Salts: A 2004 Global Trade Perspective. Icon Group International, Inc., 2005.

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7

Parker, Philip M. The 2007 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Pyrimidine Ring, Piperazine Ring, or Unfused ... Ring, and Nucleic Acids and Salts in China. ICON Group International, Inc., 2006.

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8

Parker, Philip M. The 2007 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Pyrimidine Ring, Piperazine Ring, or Unfused ... Ring, and Nucleic Acids and Salts in India. ICON Group International, Inc., 2006.

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9

Parker, Philip M. The 2007 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Pyrimidine Ring, Piperazine Ring, or Unfused ... and Nucleic Acids and Salts in United States. ICON Group International, Inc., 2006.

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Частини книг з теми "Pyrimidine ring"

1

Shishkin, Oleg V., Leonid Gorb, and Jerzy Leszczynski. "Conformational Flexibility of Pyrimidine Ring in Nucleic Acid Bases." In Practical Aspects of Computational Chemistry, 399–413. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2687-3_21.

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2

Nishikawa, Michihiro. "Details of Molecular Bistability Based on Pyrimidine Ring Rotation in Copper(I) Complexes." In Springer Theses, 25–61. Tokyo: Springer Japan, 2013. http://dx.doi.org/10.1007/978-4-431-54625-2_2.

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3

Brown, E. G. "Pyrimidines." In Ring Nitrogen and Key Biomolecules, 88–127. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-4906-8_5.

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4

Nishida, Y., S. Suzuki, and T. Miyamoto. "Suppression by 5′-Methylthioadenosine of Histamine or Leukotriene-Induced Contraction in Isolated Guinea Pig Tracheal Rings." In Purine and Pyrimidine Metabolism in Man V, 29–33. New York, NY: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-1248-2_5.

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5

S. Laitonjam, Warjeet, and Nimalini Moirangthem. "Construction of Biologically Active Five- and Six-Membered Fused Ring Pyrimidine Derivatives from 1,3-Diarylthiobarbituric Acids (DTBA)." In Strategies Towards the Synthesis of Heterocycles and Their Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108842.

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Анотація:
Several derivatives of fused pyrimidines were synthesized in maximum yields by using the respective condensation products, namely, 5-ethoxymethylene-1,3-diaryl-2-thiobarbituric acids and 5-phenyl-methylene-1,3-diaryl-2-thiobarbituric acids, which can be obtained from 1,3-diarylthiobarbituric acids (DTBA). These condensation products possessing three electrophilic centres could undergo cyclocondensation with various binucleophiles to give various fused heterocycles of pyrimidine derivatives, such as pyrazolo[3,4-d]pyrimidine-6-thiones, 5,7-diaryl-4-oxo-isoxazolo[5,4-d]pyrimidine-6-thiones, 5-oxo-pyrimido[4,5-d]pyrimidine-7-thiones, 2-thioxo-pyrano[2,3-d]pyrimidine-4-ones, pyrido[2,3-d]pyrimidines, quinazoline-4-oxo-2-thiones.
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6

van der Plas, H. C. "Pyrimidine–Pyridine Ring Interconversion." In Advances in Heterocyclic Chemistry, 31–70. Elsevier, 2003. http://dx.doi.org/10.1016/s0065-2725(03)84002-3.

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7

Sako, M. "Of Pyrido[2,3-]pyrimidines with a Hydrogenated Pyrimidine Ring." In Six-Membered Hetarenes with Two Identical Heteroatoms, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01499.

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8

Ishikawa, T. "By Annulation to the Pyrimidine Ring." In Six-Membered Hetarenes with Two Identical Heteroatoms, 1. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-116-00618.

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9

Seela, F., N. Ramzaeva, and H. Rosemeyer. "Purines Reduced in the Pyrimidine Ring." In Six-Membered Hetarenes with Two Identical Heteroatoms, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01327.

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10

Ishikawa, T. "By Annulation to the Pyrimidine Ring." In Six-Membered Hetarenes with Two Identical Heteroatoms, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01624.

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Тези доповідей конференцій з теми "Pyrimidine ring"

1

Liu, Ming, Long Liang, Gang Liu, and Shiqiang Cui. "Synthesis, properties and application in optical memory of a photochromic diarylethene bearing pyrimidine ring." In 2012 5th International Conference on Biomedical Engineering and Informatics (BMEI). IEEE, 2012. http://dx.doi.org/10.1109/bmei.2012.6512898.

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2

Shutalev, Anatoly, and Anastasia Fesenko. "A Novel Ring Expansion of Pyrimidines to 1,2,4-Triazepines." In The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a018.

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