Дисертації з теми "Pyrazole-4"
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Karahan, Dag Fulya. "Synthesis Of 5-ferrocenyl-4-((4-nitrophenyl)sulfenyl)-1h-pyrazoles By Electrophilic Cyclization." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613443/index.pdf.
Повний текст джерелаDemirci, Deniz. "Synthesis Of 4-phenylselenyl-1h-pyrazoles By Electrophilic Cyclization." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613910/index.pdf.
Повний текст джерелаBarus, M. M. "А new approach to the preparation of 4-difluoromethyl-1Н-pyrazole-3-carboxylic acids". Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19532.
Повний текст джерелаYazici, Ceyda. "Synthesis Of 4-iodopyrazole Derivatives." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609750/index.pdf.
Повний текст джерелаC for 5 h. Finally, acetylenic phenyl hydrazone derivatives were subjected to electrophilic cyclization by treating with excess molecular iodine at 80 °
C for 3 h. Although electrophilic cyclization is commonly used in organic chemistry, it has not been employed for the cyclization of acetylenic phenyl hydrazones to pyrazole derivatives. Under optimized conditions, these reactions afforded 1-aryl-5-alkyl/aryl-4-iodopyrazole derivatives in moderate to good yields as the single or the major product of the reactions. In some cases, 1-aryl-5-alkyl/arylpyrazole derivatives resulted from these reactions as minor products. In conclusion, 4-iodopyrazole derivatives were synthesized for the first time directly from acyclic starting materials, ,-acetylenic phenylhydrazones and iodine, via electrophilic cyclization.
Cottineau, Bertrand. "Contribution à l'étude du 3-hydroxy-1H-pyrazole-4-carboxylate d'éthyle : application à la synthèse de composés antidiabétiques." Orléans, 2002. http://www.theses.fr/2002ORLE2014.
Повний текст джерелаKivrak, Arif. "Development Of New Methods For The Synthesis Of Pyrazoles, 4-iodopyrazoles, Isoxazoles And 1,2,4-oxadiazoles." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612945/index.pdf.
Повний текст джерела,&beta
-alkynic hydrazones by molecular iodine and copper iodide were investigated as new ways for the synthesis of 4-iodopyrazoles and pyrazoles, respectively. Initially, &alpha
,&beta
-alkynic hydrazones were prepared by the reactions of propargyl aldehydes and ketones with hydrazines. Then &alpha
,&beta
-alkynic hydrazones were treated with molecular iodine in the presence of NaHCO3, which afforded 4-iodopyrazoles in good to excellent yields. Subsequently, the same reactions were carried out with CuI in the presence of NEt3, which furnished corresponding pyrazoles in good yields. Moreover, ferrocenyl-substituted 4-iodopyrazoles and pyrazole derivatives were synthesized from corresponding
Toto, Patrick. "Contribution à l'étude du 1H-pyrazole-4-carboxylate d'éthyle et de ses dérivés : application à la synthèse de nouveaux hétérocycles polycondensés." Orléans, 2004. http://www.theses.fr/2004ORLE2001.
Повний текст джерелаDesalegn, Nebiyou. "Kinetic Studies Of The Thermolysis Of 3-Halogenated-4,5-Dihydro-3h-Pyrazoles." Digital Archive @ GSU, 2005. http://digitalarchive.gsu.edu/chemistry_theses/1.
Повний текст джерелаPiovesan, Luciana Almeida. "Síntese de novos heterociclos a partir do ácido levulínico." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/4233.
Повний текст джерелаThe synthesis of new compounds alkyl 3-azolyl propanoate e alkyl 3-azolyl propanoic acid structurally analogues to gamma-aminobutiric acid (GABA) is reported. One more time using the acetal acylation method, now the acetal derivative of 4-oxopentanoic acid (levulinic acid), the methyl 4,4- dimethoxypentanoate, were obtained the precursors methyl 7,7,7-trifluoro[chloro]-4- methoxy-6-oxo-heptenoates, 1,3-dieletrophilic precursor with alcanoate substituent. Are presented efficient and regioespecific synthetic routes from reactions of cyclocondensation [3+2] among 1,3-dieletrofilic precursors with hydroxylamine and different hydrazines, until training isoxazoles and pyrazoles, functionalized with the side chain alkyl propanoate or propanoic acid. Simultaneously to the formation of heterocycles, were studied the hydrolysis reaction of trichloromethyl group and transesterification reaction of methyl propanoate, in the same reactional medium. All products are novel, presenting a good to excellent yields, high purity and the structures were assigned by 1H NMR, 13C NMR and mass spectrometry.
A síntese de novos compostos 3-azolil-propanoatos de alquila e 3-azolilácidos propanóicos, análogos estruturalmente ao ácido gama-aminobutírico (GABA) é relatada. Novamente aplicando o método de acilação de acetais, agora ao acetal derivado do ácido 4-oxopentanóico (ácido levulínico), o 4,4-dimetoxipentanoato de metila, foram obtidos os precursores 7,7,7-triflúor[cloro]-4-metoxi-6-oxo-heptenoatos de metila, precursores 1,3-dieletrofílicos com o substituinte alcanoato. São apresentadas rotas sintéticas eficientes e regioespecíficas a partir de reações de ciclocondensação [3+2] entre os precursores 1,3-dieletrofílicos, com hidroxilamina e hidrazinas diferentes, até a formação de isoxazóis e pirazóis, funcionalizados com a cadeia lateral propanoato de alquila ou ácido propanóico. Simultaneamente à formação dos heterociclos, foram estudadas as reações de hidrólise do grupamento triclorometila e hidrólise ou transesterificação do propanoato de metila, no mesmo meio de reação. Todos os produtos obtidos são inéditos, apresentando rendimentos de bons a excelentes e pureza alta e suas estruturas foram atribuídas por RMN1H e 13C e por espectrometria de massas.
Oleksik, Laurence. "Methodology for the synthesis of 4 or 5-substituted-3-perfluoroalkyl pyrazoles." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/30087.
Повний текст джерелаPanasenko, N. V. "Synthesis and fluorescence spectrum of 9-(4-pyrazolyl)decahydroacridindiones-1,8." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19545.
Повний текст джерелаMoiseev, Andrey G. "Synthesis and photochemistry 3,5-dialkyl-3,5-dihydro--3,5-diphenyl-4H-pyrazol-4-ones." Bowling Green, Ohio : Bowling Green State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1134948701.
Повний текст джерелаOliveira, Lanussy Porfiro de. "Atividade analgésica, anti-inflamatóriae vasorelaxante de dois derivados pirazólicos: 5-[1-(4- fluorfenil)-1H-pirazol-4-IL]-2H-tetrazola(LQFM 020) e 5- [1-(2-fluorofenil)-1H-pirazol-4-IL]-2H-tetrazola (LQFM 039)." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/4876.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Inflammation is a complex process that aims to protect the body eliminating the harmful agent and to promote tissue repair is characterized by classic signs: pain, heat, redness and swelling as a result of failure to resolve the inflammatory process may occur loss of function. Control of pain and inflammation leads to the search for new drugs both analgesic and antiinflammatory drugs with good efficacy to aid in the treatment of these deseases. The aim of this study was to evaluate the pharmacological effects of two pyrazole derivatives. In acute nociception tests LQFM 020 (9, 17.5 and 35 mg/kg) and LQFM 039 (17.5, 35 and 70 mg/kg) reduced the number of writhing dose dependent manner to 53, 48 and 35; and 57, 52, 42, respectively, while the control group the number of writhes was 88. In the formalin test this antinociceptive effect was confirmed by the reduction in time reactivity to pain in both test phases, the time in the control group was 78 and 72s in the first phase and 150 and 128s in the second phase, with LQFM for 020 and 039 LQFM in the first phase was to reduce 50 and 47s and the second phase to 97 and 74s respectively. In bending the tail the groups of mice treated with LQFM 020 and LQFM 039 test were not able to increase the latency to thermal stimulus demonstrated that the analgesic effect does not involve central mechanisms. Furthermore, the results of the enzymatic activity of cyclooxygenase (COX) and phospholipase (PLA2) in vitro tests indicated no part of the mechanism of action involved in the activity of these compounds. In vascular reactivity tests LQFM 020 promoted vasorelaxant effect presenting maximum effect (Emax) of 93% in aortic preparations with endothelium and maximum effect (Emax) of 91% without endothelium . LQFM 039 also promoted vasorelaxant effect with maximum effect (Emax) of 80% when tested in preparations with endothelium and maximum effect (Emax) of 76% without endothelium, given this result, we investigated the mechanism of action of these compounds. Our results showed that LQFM 020 and LQFM 039 demonstrated the involvement of NO/cGMP pathway and suggest also the involvement of sensitive Ca2+ channels in the plasma membrane voltage.
A inflamação é um processo complexo que tem como objetivo proteger o organismo, eliminando o agente lesivo, e promover a reparação tecidual sendo caracterizada por: dor, calor, rubor, edema e como consequência da não resolução do processo inflamatório pode ocorrer a perda da função. O controle da dor e inflamação leva a busca por novos fármacos tanto analgésicos quanto anti-inflamatórios com boa eficácia para auxiliar no tratamento destas doenças. O objetivo desse trabalho foi avaliar os efeitos farmacológicos de dois derivados pirazólicos. Nos testes de nocicepção aguda, LQFM 020 (9, 17,5 e 35 mg/kg) e LQFM 039 (17,5, 35 e 70 mg/kg), reduziram o número de contorções abdominais de maneira dose dependente para 53, 48 e 35 e para 57, 52 e 42, respectivamente, enquanto que no grupo controle o número de contorções foi de 88. No teste da formalina este efeito antinociceptivo foi confirmado com a redução no tempo de reatividade à dor nas duas fases do teste, o tempo no grupo controle foi de 78 e 72s na primeira fase e de 150 e 128s na segunda fase sendo que para LQFM 020 e LQFM 039 na primeira fase a redução foi para 50 e 47s e na segunda fase para 97 e 74s respectivamente. No teste de flexão de cauda os grupos de camundongos tratados com LQFM 020 e LQFM 039 não aumentaram a latência ao estímulo térmico demonstrando que o efeito analgésico não envolve mecanismos centrais. Os resultados dos testes de atividade enzimática de cicloxigenase (COX) e fosfolipase (PLA2) in vitro sugere que a inibição destas enzimas não faz parte do mecanismo de ação envolvido na atividade desses compostos. Nos testes de reatividade vascular LQFM 020 promoveu efeito vasorrelaxante apresentando efeito máximo (Emax) de 93% em preparações de aorta com endotélio e efeito máximo (Emax) de 91% sem o endotélio. LQFM 039 também promoveu efeito vasorrelaxante com efeito máximo (Emax) de 80% quando testadas em preparações com endotélio e efeito máximo (Emax) de 76% sem o endotélio, dado este resultado, foi investigado o mecanismo de ação desses compostos. Os resultados mostraram que LQFM 020 e 039 LQFM demonstram o envolvimento da via NO / GMPc e também sugerem o envolvimento de canais de Ca2+ sensíveis à voltagem na membrana plasmática.
Panasenko, N. V., and М. K. Bratenko. "Synthesis of 3-(3-aryl-1-phenyl-1H-4-pyrazolil)-chromen-2-ones." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/16864.
Повний текст джерелаCHAOUI, ROQUAI M'HAMMED. "Extraction d'indium (iii) en milieu chlorure par le 3-phenyl-4-benzoyl-5-hydroxy-isoxazole. Synergies. Comparaisons avec les 4-acyl-5-hydroxy-pyrazoles." Université Louis Pasteur (Strasbourg) (1971-2008), 1995. http://www.theses.fr/1995STR13134.
Повний текст джерелаGUIGUEMDE, ISSAKA. "Transfert d'ions metalliques divalents entre phases liquides par des bis(5-hydroxy-pyrazol-4-oyl) alcanes; selectivite." Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR13178.
Повний текст джерелаBensliman, Chakib. "Von Alpha,Beta-ungesättigten Ketonen und ihren Oximen zu Pyrazol-4-on-1,2-dioxiden, potentiellen NO-Pharmaka /." [S.l. : s.n.], 1998. http://www.gbv.de/dms/bs/toc/253245788.pdf.
Повний текст джерелаLiebold, Claudia. "Immobilisierung von Palladium mittels 1,4-Bis-(4‘-pyrazolyl)benzen und dessen Anwendung in der heterogenen Katalyse." Doctoral thesis, Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2013. http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-124709.
Повний текст джерелаDo, Khoa Quang. "Design, Synthesis and Binding Studies of Trisubstitutedpyrazolo[3,4-d]pyrimidines." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/367533.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Science
Full Text
ARICHI, JAOUAD. "Extraction liquide-liquide de terres rares par des 4-acyl-5-hydroxy-pyrazoles et -isoxazoles equilibres et cinetique de transfert. Synergies." Université Louis Pasteur (Strasbourg) (1971-2008), 1998. http://www.theses.fr/1998STR13007.
Повний текст джерелаBacher, W. [Verfasser]. "Zur Reaktion von 4-Acylsubstituiertem 1-Phenyl-3-methyl-pyrazolon-5 mit Actinidenionen in waessriger Loesung / W. Bacher." Karlsruhe : KIT-Bibliothek, 2009. http://d-nb.info/118690495X/34.
Повний текст джерелаLiebold, Claudia [Verfasser], Florian [Akademischer Betreuer] Mertens, Florian [Gutachter] Mertens, and Roger [Gutachter] Gläser. "Immobilisierung von Palladium mittels 1,4-Bis-(4‘-pyrazolyl)benzen und dessen Anwendung in der heterogenen Katalyse : Immobilisierung von Palladium mittels 1,4-Bis-(4‘-pyrazolyl)benzen und dessen Anwendung in der heterogenen Katalyse / Claudia Liebold ; Gutachter: Florian Mertens, Roger Gläser ; Betreuer: Florian Mertens." Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2013. http://d-nb.info/1220911631/34.
Повний текст джерелаHEMONIC, DANIELE. "Etude cinetique et thermodynamique de l'extraction du cuivre par la 1-phenyl-3-methyl-4-stearoyl-pyrazol-5-one : comparaison a d'autres extractants." Paris, ENMP, 1987. http://www.theses.fr/1987ENMP0156.
Повний текст джерелаHemonic, Danielle. "Etude cinétique et thermodynamique de l'extraction du cuivre par la 1-phényl-3-méthyl-4-stéaroyl-pyrazol-5-one comparaison à d'autres extractants /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376059420.
Повний текст джерелаHlimi, Fouzia. "Cycloaddition de diarylnitrilimines sur des dérivés de la benzodioxine 1,4 et de la benzoxazine-1,4 : regiochimie de la réaction sur un alcene portant un groupe donneur et un groupe accepteur sur la même extrêmité." Besançon, 1987. http://www.theses.fr/1987BESA2018.
Повний текст джерелаTuloup, Rémy. "Addition du diazomethane aux thiazabutadienes : une application du cycle pyrazoline a la synthese multi etapes d'amino-7 formyl-4 cephemes." Rennes 1, 1988. http://www.theses.fr/1988REN10029.
Повний текст джерелаSahmoune, Amar. "Extractions synergiques de metaux divalents de transition par association d'une acyl-4-pyrazolone-5 avec des polyethers cycliques et acycliques." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13116.
Повний текст джерелаSahmoune, Amar. "Extractions synergiques de métaux divalents de transition par association d'une acyl-4-pyrazolone-5 avec des polyéthers cycliques et acycliques." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37618386w.
Повний текст джерелаTuloup, Rémy. "Addition du diazométhane aux thiazabutadiènes une application du cycle pyrazoline à la synthèse multi-étapes d'amini-7 formyl-4 céphèmes /." Grenoble : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37619005g.
Повний текст джерелаMoraes, Paulo Alexandre de. "N-alquilação regiosseletiva de pirazóis empregando 4-alcóxi(amino)-5-bromo-1,1,1-trifluorpent-3-en-2-onas." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/10628.
Повний текст джерелаA presente dissertação relata a síntese de três séries inéditas de heterociclos nitrogenados trifluormetil substituídos, que exploram a versatilidade sintética e a regiosseletividade das 4-alcóxi-5-bromo-1,1,1-trifluorpent-3-en-2-onas e das 4-amino-5-bromo-1,1,1-trifluorpent-3-en-2-onas, em reações com nucleófilos nitrogenados. As primeiras duas séries dos compostos 1-(3-alcóxi-5-trifluorometil-2,3-diidrofuran-3-il)-4,5-alquil-3-(trifluorometil)-1H-pirazóis, foram sintetizadas através do processo de N-funcionalização de pirazóis, a partir da reação com as 4-alcóxi-5-bromo-1,1,1-trifluorpent-3-en-2-onas, cujo o caminho mecanístico se deu através de uma reação de adição nucleofílica de Michael. Inicialmente, ocorre a adição do pirazol nucleofílico na posição beta (Cβ) das enonas bromadas, seguida de uma reação de ciclocondensação intramolecular formando o anel furano, com a substituição átomo de bromo pelo oxigênio enólico, resultando na formação de treze compostos inéditos, com rendimentos entre 55 e 86%. Outra série de compostos (E)-4-(amino)1,1,1-triflúor-5-(5-metil-3-(trifluormetil)-1H-pirazóis-1-il)pent-3-en-2-onas, foi sintetizada através da reação de N-alquilacão, via substituição nucleofílica bimolecular (SN2), onde o átomo de bromo na posição cinco (Cγ), das 4-amino-5-bromo-1,1,1-trifluorpent-3-en-2-onas, foi substituído pelo nitrogênio nucleofílico do anel pirazolínico, promovendo a formação de sete produtos N-alquilados, com rendimentos que variam entre 65 e 85%. Além disso, um estudo de regiosseletividade das reações N-funcionalizadas de pirazóis está descrito, onde a avaliação das condições reacionais e também de fatores estéricos e eletrônicos dos substituintes presentes nos substratos, foram determinantes para formação do produto formado. Os produtos obtidos neste trabalho foram caracterizados por ressonância magnética nuclear de 1H e 13C, espectrometria de massas de baixa e alta resolução, análise elementar e difratometria de Raio X.
Perez-Ruiz, Edgar. "Analyse vibrationnelle et structurale comparée de biomolécules à visée thérapeutique : 1,7 dihydro-6h-purine-6-thione (6-mercaptopurine), 1,5-dihydro-4h-pyrazolo(3,4-d)pyrimidine-4-thione (tisopurine) et leurs chlorures." Montpellier 1, 1997. http://www.theses.fr/1997MON13521.
Повний текст джерелаHolz, Karsten. "Enol-Konjugate von 1-Phenyl-3-methyl-4-amino-3-pyrazolin-5-on als "minor metabolites" im Stoffwechsel von Metamizo. (Novalgin R) : Untersuchungen zur Analytik, zu Nachweis, Bildung und Verbleib metastabiler Phase-II-Metaboliten bei der Ratte /." [S.l. : s.n.], 1997. http://www.gbv.de/dms/bs/toc/226144828.pdf.
Повний текст джерелаKuleshova, Olena. "2-azahetaryl-3-enaminonitriles cycliques pour la synthèse d'azahétérocycles fonctionnalisés, la complexation de métaux et la conception de sondes optiques." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30127/document.
Повний текст джерелаThe research carried out in the course of this PhD work is centered on cyclic 2-azahetaryl-3-enaminonitrile derivatives which represent an attractive scaffold due to its high number of potential reactive sites. Regioselective functionalization of each site may give access to various structurally different Nitrogen-containing moieties featuring an azaheterocycle substituent. One first application in heterocyclic synthesis of 2-azahetaryl-2-(1-R-pyrrolidin-2-ylidene)acetonitriles, readily accessed from available and cheap starting materials, is their involvement in Knorr-type synthesis of pyrazoles (isoxazoles) where they play the role of the 1,3-dielectrophiles. Thus 4-azahetaryl-3-(ω-aminopropyl)-1H-pyrazole (isoxazole)-5-amines are formed with complete regioselectivity in good yields 50-85%. This establishes an efficient and easily reproducible two-step approach to heterocycle- substituted amino-pyrazoles from heterocyclic acetonitriles. Unprecedented subsequent transformations were carried out providing an access to regioselectively derivatized polyamino azoles, tetracyclic compounds in up to 45% overall yield and arylated pyrazoles in up to 71% yield through diazotization, followed by arylation through Suzuki-Miyaura cross-coupling or C-H activation. We illustrated the unprecedented but efficient nitrogen protection as a nitrosamine during the Pd-catalyzed cross-coupling. Also the possibility of pyrazoles C-H activation in order to get densely substituted pyrazoles was shown for the first time. We also performed the quaternarization of the nitrogen of the heterocycle to investigate the effect of a cationic moiety on the regioselectivity of the reaction of such azahetaryl-3-enaminonitrile derivatives with 1,2-binucleophiles. The increased electron demand on the heterocycle induced a reaction path shift that produced the azole ring- opened product. Derivatives of benzoxazole and benzimidazole form second way products straight away, while the one of benzothiazole undergoes the "classical" transformation pathway and subsequent nucleophilic substitution at C-2 center of benzothiazole leading to azepine cycle formation. In the case of benzoxazolyl substituted enaminonitriles under the same conditions both regioisomers are formed. Formylation reaction of 2-(benzo[d]thiazol-2-yl)-2-(pyrrolidin-2-ylidene) acetonitrile with N,N-dimethylformamide dimethyl acetal (DMF DMA), followed by further reamination and cyclization under basic conditions gave rise to pyrrolo[3,2-c]pyridine-6-imine, a compound that exhibits a high fluorescent quantum yield (Φ = 61%) and proved to be very sensitive to protonation. Both characteristics are expected to be useful to develop an unprecedented water detection test for aprotic solvents. We have demonstrated that such a fluorometric method for determining water content in DMSO presents a limit of detection of 0.068%. From other enaminonitriles reactions with DMF DMA provided either a mixture of methylated and formylated products, or only methylated products (few adducts also shown non reactivity). These observations prompted us to assume that the presence of easily accessible NH group is essential in formylation of the C-3 center of pyrrolidine allowing to propose a mechanism for this uncommon reaction. 2-Azahetaryl-2-(pyrrolidin-2-ylidene)acetonitriles and their 3-oxo-benzo- analogues were also used to create: a) visible spectrophotometric probes for Zn(II) b) water stable BF2-rigidified complexes that overcome the limitations of BODIPY-dyes and have Stokes shifts up to 9000 cm-1, emission at violet-blue range, fluorescence both in solution (Φ up to 90%) and crystalline state; c) films of polymeric composites exhibiting photovoltaic effect
Ciccolini, Cecilia. "Synthesis of Mono and Poly-Heterocycles starting from 1,2-Diaza-1,3-Dienes (or precursors) as Building Blocks." Doctoral thesis, Urbino, 2020. http://hdl.handle.net/11576/2674162.
Повний текст джерелаRIFI, EL HOUSSEINE. "Extraction metallique par des gels hydrophobes." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13158.
Повний текст джерелаLAKKIS, ZAHREDDINE ZEINAB. "Aspects thermodynamiques et cinetiques de l'extraction de metaux divalents par des acyl-4-pyrazolones-5." Strasbourg 1, 1986. http://www.theses.fr/1986STR13001.
Повний текст джерелаMetabanzoulou, Jean-Pierre. "Mecanisme de la complexation de l'ion uo : :(2)**(2+) par des di(acyl-4 pyrazolones-5), des ethers-couronnes, des diazapolyoxamacrocycles et des ligands apparentes." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13146.
Повний текст джерелаDiantouba, Bertin Aimé. "Effets structuraux des acyl-4-pyrazolones-5 dans l'extraction liquide-liquide des cations metalliques divalents." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13093.
Повний текст джерелаMarouani-Keraghel, Saïda. "Reduction electrochimique de composes d'uranyle en milieu organique." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13175.
Повний текст джерела洪讚誠. "Synthesis and thermal reaction of dimethyl-3, 3-cyclopentyl-3H-pyrazole-4, 5-dicarboxylate." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/46555386938756761561.
Повний текст джерела靜宜大學
應用化學研究所
86
Thermolysis of dimethy1-3,3-cyclopentyl-3H-pyrazole-4,5-dicarboxylate(20) afforded dimethy1-4,5,6,7-tetrahydroindazole-2,5-dicarboxylate(24) and dimethy1-1,5-tetramethylene-pyrazole-3,4-dicarboxylate(25) in 69% and 8%, respectively. The mechanism of this reaction is suggested to undergo two competitive pathways. (1)After heating the compound 20 can undergo ring expansion(1,5-sigmatropic migration), i.e. the cyclopentyl group can ring-expand form C3 to N2 to form the compound. 25. (2) Alternatively, the cyclopentyl group of the compound 20 can undergo ring expansion from C3 to C4, and the ester group at C4 can simultaneously migrate to N2(1,5-anticlockwise) to form the compound 24. The activation energy of the thermal reaction of compound 20 was measured be 8.6kcal/mole.k
Chen, Yin-Ju, and 陳胤儒. "Pyrazole and Triazole Functionalized Calix[4]arenes as Highly Selective Fluorogenic Sensors for Sliver (I) and Mercury (II)." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/82766858787652129622.
Повний текст джерела國立交通大學
應用化學系碩博士班
101
Azole heterocycles are interesting compounds because many of them are with biological activities and the azole ligands have been widely used in coordination chemistry. Pyrazoles have attracted considerable interest as ligands, because their conjugate bases, pyrazolates, have been found to bind metal ions in a variety of coordination modes. In this thesis, we report the synthesis of a pyrazolyl methylpyrene functionalized calix[4]arene 35 and a 1,3-alternate calix[4]arene 41 with pyrazolyl methylpyrene on the one end and triazolylphenyl on the other end. Metal ion binding abilities of 35 and 41 were invesitigated by UV-vis, fluorescence, and 1H-NMR spectroscopy. Using UV-vis and fluorescence spectra for screening, we found both 35 and 41 show a strong excimer emission as a free ligand, however, they showed a high selectivity toward Ag+ and Hg2+ ions with strong fluorescent quenching in CHCl3/MeOH (v/v = 3/1), respectively. Compound 35 showed 95% quenching of fluorescence by Ag+ and 97% quenching of fluorescence intensity by Hg2+, and compound 41 showed 41% quenching of fluorescence by Ag+ and 93% quenching of fluorescence intensity by Hg2+. Furthermore, the Job Plot and 1H-NMR titration experiment showed that the binding ratio of 35 toward Ag+ and Hg2+ were both 1:1 complex, and 41 toward Ag+ and Hg2+ were both 1:2 complex. The binding constant of 35 with Ag+ and Hg2+ was determined by fluorescence quenching to be 3.00 × 104 M-1 and 2.99 × 104 M-1, respectively. While the binding constant of 41 with Ag+ and Hg2+ was determined similarly to be 9.24 × 1011 M-1 and 1.46 × 1012 M-1, respectively. The binding constants of 35 with Ag+ and Hg2+ were also determined using UV-vis method to be 3825 and 2993 M-1, respectively.
陳孟榆. "Pyrazole Calix[4]arenes as Highly Selective Fluorogenic Sensors for Silver (I) and Mercury (II) and Synthesis of Pillar[5]arene Derivatives." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/04499796060226609005.
Повний текст джерела國立交通大學
應用化學系碩博士班
99
This study is divided into two parts. First, two series of lower-rim modified calix[4]arene with pyrazole substituents were synthesized. Using phenyl pyrazole calix[4]arenes as basic synthesis frameworks, we synthesized phenylanthryl pyrazole calix[4]arenes 76 and 77 and control compounds 78 and 79 as fluorogenic ions sensors. Based on the results from UV-Vis, fluorescence and 1H-NMR spectrometry, we found that pyrazole calix[4]arenes 77 and 79 recognized Ag+ and Hg2+ with excellent selectivity in MeOH/CHCl3 (v/v = 4:1), respectively. Compound 77 induced 141% enhancement of fluorescence intensity toward Ag+, and compound 79 showed 51% fluorescence quenching effect toward Hg2+.Furthermore, the complexation of compound 77 with Ag+ and 79 with Hg2+ both showed 1:1 host-guest stoichiometry based on by Job plot obtained from fluorescence and 1H-NMR titration spectra. We also found the binding constants of 77 with Ag+ was (1.12 ± 0.17) × 104 M-1 and 79 with Hg2+ was (1.33 ± 0.20) × 104 M-1.Second, the research was focused on the reaction condition to synthesize pillar[5]arenes. Pillar[5]arenes 38 and 83 were successfully and facile synthesized by cyclization reaction with high yield. These compounds were obtained via borontrifloride etherate catalyzed procedure with 1,4-dialkoxyphenyl monomer and paraformaldehyde under 0.1 M solution. Besides, a synthetic route to difunctional pillar[5]arene 95 was also developed by combining two different monomers with 4:1 ratio using the conditions stated above.
Chou, Li-Chen, and 周立琛. "Synthesis and anticancer activity of 1,3,5-substituted selenolo[3,2-c]pyrazole analogues、Synthesis and anticancer activity of hydrophilic phosphate prodrugs of 2-phenyl-4-quinolone derivatives." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/72588313584030324230.
Повний текст джерела中國醫藥大學
藥物化學研究所博士班
97
The purpose of this study is to develop compounds with potential anticancer activity as new drug candidate. This thesis consists of two parts. In the first part, four different skeletons of YC-1 derivatives [furopyrazole derivatives (11-22, 28-36), thienopyrazole derivatives (42-45, 50-53), selenopyrazole derivatives (67-72, 75-77), and indazole derivatives (99−118, 123−128)] were synthesized in order to expand the substance patent’s inclusion of YC-1 and find new candidate with better anticancer activity than YC-1, and constructed their SAR in NCI-H226 and A498 cells. Compound 13 (CLC107), 44 (CLC015), 69 (CLC005), and 127 (CLC802a) were chosen for evaluation against 60 human cancer cell lines (the NCI-60) and COMPARE program analysis, and indicated that four compounds were with great development value since they possessed novel mechanism of action different from existing anticancer drugs. Finally compound 127 was proved to demonstrate anticancer activity similar to YC-1 in animal model, it is thus a new candidate of YC-1 in drug development. In the second part, the problem of 2-phenyl-4-quinolone derivatives in pharmacokinetics is resolved. In order to improve solubility problem, a phosphoric acid was attempted to be attached to 4-ketone of 2-phenyl-4-quinolone, and thus phosphate monosodium salts of 2-phenyl-4-quinolone derivatives were successfully created, which were expected to be applied by po and iv routes in clinics. Among 2-phenyl-4-quinolone derivatives, we focus on compound 8 which demonstrated the most significant antitumor activity. According to the data of Pharmacokinetics, compound 35 was proved to be transformed in vivo to compound 8 (CHM-1). After the assessment of safety pharmacology of compound 35 in enzyme activity assay and receptor binding assay, we predict it is very effective and safe drug while there should not be too many side effects in clinical trials. Besides, it showed excellent antitumor activity in SKOV-3 Xenograft SCID mice model and CT-26 colon adenocarcinoma Balb/c mice orthotopic model. It is confirmed that compound 35 (CHM-1-P-Na) is a drug candidate for further development as a potential anticancer agent in the clinic. We hope this series of compounds can successfully become clinical therapeutic agents which are beneficial to human beings.
Lee, Kun-Ti, and 李昆諦. "(I) Synthesis of Triphenylenyl Triazole Bridged Bispillar[5]arene as Fluorogenic Sensor of Pyridinium and Imidazolium Cations (II) Pyrene Pyrazole Functionalized Calix[4]arene as Highly Selective Fluorogenic Sensor for Silver (I) and Mercury (II) ions." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/4bbh2q.
Повний текст джерела國立交通大學
應用化學系碩博士班
105
In this study, we have synthesized triphenylenyl triazole bridged pillar[5]arene dimer, triphenylenyl triazole substituted pillar[5]arene and stilbene triazole bridged pillar[5]arene dimer as compound 37, 41, 47, respectively. Based on the results from UV-Vis absorption spectroscopy and fluorescence emission spectroscopy, compound 37 showed good binding abilities toward pyridinium cations G3-G4 and imidazolium cation G5, and compound 41 showed good binding abilities toward G5 only. But, we won’t study compound 47 furthmore, which fluorescence characteristic vanished after exposured by UV light, because of trans-cis isomerism of stilbene group. According to the more detail research of UV-Vis spectroscopy, fluorescence spectroscopy, Hill plot and 1H NMR titration, we found that binding ability 37•G3 > 37•G5 > 37•G4, which binding constant were 2.21 × 105 M-2, 5.83 × 104 M-2 and 2.12 × 104 M-1, determing by Hill equation. Furthermore, the high resoluition mass spectrometry showed that the binding ratio of 37 toward G3, G5 and G4 were 1:2, 1:2 and 1:1, respectively. The same method were used to confirm that binding constant and binding ratio of compound 41 toward G5 were 4.37 × 103 M-1 and 1:1. Compound 37 showed binding abilities toward imidazolium cations guest G6-G8, which have different anion Cl-, BF4- and PF6-. Fluorescence intensity of host 37 have best fluorescence enhancement effect when G8 was added, compared with G5-G7. However, there is no significant difference of binding constant between guest G8-G11, which alkyl group have different carbon chain length, toward compound 37. Based on the discussion of binding ability of compound 37 toward G8-G11 and 1H NMR titration, we surmised that guest compounds using cation side to penetrate into the cavity of pillar[5]arene from the side without substituted or bridged group and alkyl chain of guest are outside host cavity. The other part of the study is according to the previous work of laboratory upperclassmen, Yin-Ju Chen. In his study, he reported the synthesis of a pyrazolyl methylpyrene functionalized calix[4]arene 28 and 1,3-alternate calix[4]arene 29 with pyrazolyl methylpyrene on the one end and triazolylphenyl on the other end. These two compound showed good binding ability toward Ag+ and Hg2+, but the binding ratio of compound 28 toward metal ion was ambiguous and compound 29 lack the control compound 58 to comparison. Therefore, we prepared compound 28 and confirmed the binding ratio were 1:1 toward Ag+ and Hg2+ by Job plot and high resoluition mass spectrometry. Besides, we successfully synthesized control compound 58. Based on the results from UV-Vis spectroscopy and fluorescence spectroscopy, same as compound 28, 29, compound 58 showed good binding abilities toward Ag+ and Hg2+, and binding constant were calculated for 3.89 × 107 M-4 and 3.06 × 107 M-4 by Hill equation. Compared with compound 28, 29, binding constant 29·Ag+ > 58·Ag+ > 28·Ag+ and 29·Hg2+ > 58·Hg2+ > 28·Ag2+. This result indicated the propyl group at the upper-rim of control compound 58 would assist to bind metal ion, although it’s not effective as triazole group. According to the binding constant order, Hill plot, Job plot and 1H NMR titration, we surmised that compound 58 have binding ratio 2:3 toward Ag+ and Hg2+.
Kumari, Archana. "Synthesis of Pyrazolo [3, 4-b] pyridine by Knovengel Condensation." Thesis, 2009. http://ethesis.nitrkl.ac.in/190/1/.
Повний текст джерелаChou, Shih-Yu, and 周世祐. "Calamitic heterocyclic pyrazoles formed by 1,5-bis(4-alkoxyphenyl)-l,3,5-pentanetriones." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/26770058482258289706.
Повний текст джерела國立中央大學
化學研究所
96
In this thesis, we report the synthesis, characterization and mesomorphic properties of a series of new mesogenic derivatives based on pyrazole structureies. All compounds were characterized by 1H, 13C-NMR spectroscopy and elemental analysis. The phase behaviors of these mesogenic compounds were characterized and studied by differential scanning calorimeter (DSC) and polarization optical microscope. In the serie, a new type of mesogenic compounds derived from heterocyclic pyrazoles were prepared and studied. The compounds of Tpz-Cn, exhibited smectic phases, as expected for their rod-like structures, compounds of Tpz-2Cn, exhibited columnar hexagonal phases, as expected for their discotic-like structures. The metal complexes, Tpz-2Cn-Ni, formed by reacting the pyrazoles with NiCl2 are exhibited columnar hexagonal phases too.
Lin, Kuan-Ting, and 林冠廷. "Mesogenic Heterocycles Formed by Quinoxalines, Bis–pyrazoles, and Bis–1, 3, 4–Oxadiazoles." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/u7b64v.
Повний текст джерела國立中央大學
化學學系
103
This thesis is devided into four different series. In series 1, two new structures of unsymmetric 1, 3, 4–oxa(thia)–diazoles 1a–b and 2 containing both quinoxaline and naphthalene moieties were prepared and their mesomorphic properties were investigated. The mesomorphic behavior of compounds 1–2 was studied by DSC analysis and polarized optical microscopy. All compounds 1a and 2 exhibited hexagonal columnar phases (Colh), which were also confirmed by powder XRD diffractometer. Ncell and Rar values equal to 5.23 and 22.73 Å within a slice of 9.0 Å thick were also obtained for 1a (n=16), indicating that a more disc-like structure constructed by two molecules lying side-by-side was correlated in Colh phases. In contrast, all compounds 1b were not mesogenic, and the lack of mesomorphic properties in 1b might be due to their unfavorable conformations. The PL spectra of all compounds 1a, b showed one intense peak at λmax = 509–512 nm, and these photoluminescent emissions originated from quinoxaline moiety. In series 2, four new series of quinoxaline with four kind of 1, 3, 4–oxadiazoles spacer 1a–d were designed and prepared. Their mesomorphic properties were investigated. The mesomorphic behavior of compounds 1a–1d was studied by DSC analysis and polarized optical microscopy. All compounds 1a and 1d exhibited hexagonal columnar phases (Colh), which were also confirmed by powder XRD diffractometer. Ncell values equal to 2.85 and 2.16, Rar values are 20.49 and 22.74 Å within a slice of 9.0 Å thick were also obtained for 1a (n=12) and 1d (n = 12), indicating that a single molecule was packed within the columns in Colh phases. In contrast, all compounds 1c were not mesogenic, and the lack of mesomorphic properties in 1c might be due to their unfavorable conformations. The PL spectra of all compounds 1a–1d showed one intense peak at λmax = 517–529 nm, and these photoluminescent emissions originated from quinoxaline moiety. In series 3, three new materials of catenar liquid crystals 1a–c derived from heterocyclic bisoxazoles and bisthiazoles exhibiting columnar phases were reported. All compounds 1a–c exhibited hexagonal columnar phases, which were also confirmed by powder XRD diffractometer. Compounds 1a have a slightly wider temperature range of columnar phases than those of compounds 1b, which might be attributed to higher core dipole polarized in 1a. A Ncell and Rar value equal to 2.54–2.76 and 19.99–20.45 Å within a slice of 9.0 Å thick were obtained for three derivatives 1a–c (all n = 12), indicating that a single molecule was packed within the columns in Colh phases. All derivatives showed good stabilities at temperature below T = 408.8 C on TGA analysis. The PL spectra of all compounds 1a–c showed one intense peak at λmax = 505–510 nm, and these photoluminescent emissions originated from quinoxaline moiety. In series 4, three new series of multiple heterocyclic compounds 1a–c constructed by bis–pyrazoles, bis–1, 3, 4–oxadiazoles and thiophene exhibiting mesophases were reported. Crystallographic data showed that the crystal 1a (n = 8) is a linear–shaped molecule with a molecular length of ca. 40.57 Å. However, three heterocyclic rings were not coplanar. All compounds 1a formed smectic A/C phases, and all compounds 1c exhibited columnar phases, which were confirmed by powder XRD diffractometer. A Ncell and Rar value equal to 3.91 and 18.29 Å within a slice of 9.0 Å thick were obtained for derivatives 1c (n = 8), indicating that two molecule was correlated within columns in Colh phases. All derivatives showed good stabilities at temperature below T = 383–426 C on TGA. The PL spectra of all compounds 1b–c (n = 8) showed one intense peak at λmax = 418–496 nm, and these photoluminescent emissions originated from 1, 3, 4–oxadiazole moiety.
Prokofieva, Angelina. "Bioinspired oxidation reactions of phenols with dinuclear copper complexes." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-000D-F12D-0.
Повний текст джерела詹淑秦. "Investigation of synthesis and anti-allergic activityof 2-ethyl-3, 4-dimethylfuro [ 2, 3-c ] pyrazoles." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/61087201187943624709.
Повний текст джерелаLiebold, Claudia. "Immobilisierung von Palladium mittels 1,4-Bis-(4‘-pyrazolyl)benzen und dessen Anwendung in der heterogenen Katalyse: Immobilisierung von Palladium mittels 1,4-Bis-(4‘-pyrazolyl)benzen und dessen Anwendung in der heterogenen Katalyse." Doctoral thesis, 2012. https://tubaf.qucosa.de/id/qucosa%3A22875.
Повний текст джерела