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Hadziahmetovic, Nina, Sabina Alispahic, Djenita Tuce, and Enedina Hasanbegovic-Anic. "Therapist’s interpersonal style and therapy benefit as the determinants of personality self-reports in clients." Vojnosanitetski pregled 73, no. 2 (2016): 135–45. http://dx.doi.org/10.2298/vsp140911141h.
Повний текст джерелаАнотація:
Background/Aim. In (counter)transference relationship therapist?s interpersonal style, implying the perceived relation of therapist to a client (patient) in terms of control, autonomy, care and positive feedback, has been shown to be important. The aim of our study was to assess the relationship between therapist?s interpersonal style and clients? personality self-reports. Within therapist?s interpersonal style, preliminary validation of the Therapist?s Interpersonal Style Scale has been conducted, which included double translation method, exploratory factor analysis, confirmatory factor analysis, as well as the reliability tests of the derived components. Methods. This research was conducted on a group of 206 clients, attending one of the four psychotherapy modalities: psychoanalysis, gestalt therapy, cognitive-behavioral and systemic family therapy. Beside Therapist?s Interpersonal Style Scale, Big Five Questionnaire and Therapy Benefit Scale were administered, showing good internal consistency. Results. Principal component analysis of therapist?s interpersonal style singled out two components Supportive Autonomy and Ignoring Control, explaining 42% of variance. Two-factor model of the therapist?s styles was better fitted in confirmatory factor analysis than the original 4-factor model. Structural model showing indirect and direct effects of therapist?s interpersonal styles on selfreports in clients indicates good fitness (?2(12) = 8.932, p = 0.709; goodness-of-fit index = 0.989), with Ignoring Control having direct effect on Stability, Supportive Autonomy on Therapy Benefit, and Therapy Benefit on Plasticity. Conclusion. The results of this study indicate the importance of further research on therapist?s interpersonal style, as well as further validation of the instrument that measures this construct. Besides, a client?s perception that the therapy is being helpful could instigate more explorative and approach-oriented behavior, what indirectly might contribute to a client?s stability.
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Nurjannah, Intansari. "Sujok triorigin therapy for vaginitis: case reports." International Journal of Research in Medical Sciences 12, no. 1 (December 28, 2023): 249–52. http://dx.doi.org/10.18203/2320-6012.ijrms20234011.
Повний текст джерелаАнотація:
Vaginitis cases are the most frequently encountered cases of gynaecologists in women who seek treatment at health facilities. Various therapies are sought by sufferers to overcome this condition. This case report discusses the use of Sujok triorigin therapy with the mudra method to treat the symptoms of vaginitis. Mudra method is the therapy only by using the thumb placed on certain knuckles based on the tri-origin concept and the respondents meditate for 15-20 minutes. There was no charge applied for the therapy were given to the patient. Two female patients on their 40s contacted researcher through social media to get help for their vaginitis problems. Researcher sent the instruction through picture how to apply the therapy on patients’ fingers. In the first case, this extreme vaginal itching condition had been experienced for 1 year with various treatment methods tried but none were successful. In this respondent, it took 9 days for the itching to completely disappear with therapy being done 4 times a day for about 15 minutes. The second respondent complained of extreme itching in the vagina, with a severity scale of 5 (from 1-5) and bleeding because of scratching. After 4 minutes of doing mudra, the itching went down to scale 3 and after 20 minutes the itching went down to a score of 1-2 and then was completely gone after that. In conclusion, Sujok triorigin therapy can reduce vaginitis symptoms in two respondents in a relatively short time of therapy.
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Caruso, Norma. "Sexual aversion disorder: a case study, conceptualised and treated from a psychodynamic perspective." Couple and Family Psychoanalysis 12, no. 2 (October 15, 2022): 166–82. http://dx.doi.org/10.33212/cfp.v12n2.2022.166.
Повний текст джерелаАнотація:
This article relies on psychoanalytic theory and technique to examine the dynamics of a couple with a sexual aversion disorder in one partner and to provide treatment. It uses the language of object relations, including Ogden’s (1989a,b) reformulation of Freud’s notions about the oedipal complex. In doing so, it defies the popular trend in sex therapy to employ behavioural methods, as well as the less commonly used approach to integrate psychoanalytic with behavioural techniques. The outcome supports the prospect of psychoanalytically oriented therapists reclaiming sexual difficulties as entities that are within the domain of their clinical expertise. Additionally, it adds to the literature on sexual desire disorders and because the partner, in this case, who presents with the sexual problem is male, it counters commonly held myths about male sexuality and recognises the complexity of their sexual functioning.
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Soares, Marcia Britto de Macedo, Ricardo Alberto Moreno, and Doris Hupfeld Moreno. "Electroconvulsive therapy in treatment-resistant mania: case reports." Revista do Hospital das Clínicas 57, no. 1 (February 2002): 31–38. http://dx.doi.org/10.1590/s0041-87812002000100006.
Повний текст джерелаАнотація:
Electroconvulsive therapy is known to be effective in the treatment of mood disorders, more specifically for depression and mania. Although a large body of evidence confirms the efficacy of electroconvulsive therapy in the treatment of mania, few prospective studies have been done to assess its effectiveness in treatment-resistant manic episodes. These case reports describe the initial results of a study that is being conducted to evaluate the efficacy of Electroconvulsive therapy among treatment-resistant bipolar patients. METHODS: Three manic patients (according to DSM-IV criteria) who were considered treatment-resistant underwent a series of 12 bilateral Electroconvulsive therapy sessions. Before the treatment and then weekly, they were evaluated with the following rating scales: Young Mania Rating Scale, Hamilton Rating Scale for Depression, Brief Psychiatric Rating Scale, and Clinical Global Impressions-Bipolar Version. RESULTS: The 3 patients showed a satisfactory response to Electroconvulsive therapy, although some differences in the course of response were observed. CONCLUSION: These case reports suggest that Electroconvulsive therapy needs further evaluation for the treatment of resistant bipolar patients.
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Floros, Georgios, and Ioanna Mylona. "A Psychoanalytic Approach to Internet Gaming Disorder." International Journal of Environmental Research and Public Health 20, no. 15 (August 7, 2023): 6542. http://dx.doi.org/10.3390/ijerph20156542.
Повний текст джерелаАнотація:
Background: Internet Gaming Disorder (IGD) is now an official diagnosis and significant public health challenges have been already identified regarding the provision of appropriate care to patients of all ages and the preparedness of mental health professionals to manage the disorder. Despite the existence of psychotherapeutic treatment modalities available for some time now, there is a paucity of any psychoanalytically driven treatments and the disorder is widely regarded and classified as being ‘behavioral’. This has profound implications for patients with long-standing character pathology and psychiatric comorbidities, who are underserved by the provision of health services that could efficiently address their issues. Methods: This study presents a psychoanalytic perspective on IGD, based on Kohut’s Self Psychology as applied in the treatment of other addictions. An outline of the theory, assessment and treatment modalities is presented with two case reports that illustrate its application. Results: The presentation outlines the challenges in treating IGD, expanding on the concept of guided imagery, resistance to treatment, selfobject transference and comorbidity with marijuana use and bipolar disorder. Conclusions: A psychoanalytically driven protocol can be effective in treating IGD, especially in cases with marked character pathology and low motive to engage in other treatment modalities.
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Kim, Hyunjoong, Seungwon Lee, Namjeong Cho, and Seonghyeok Song. "A Systematic Review of Case Reports on the Neck-Tongue Syndrome." Medicina 57, no. 10 (October 13, 2021): 1097. http://dx.doi.org/10.3390/medicina57101097.
Повний текст джерелаАнотація:
Background and Objectives: Neck-tongue syndrome (NTS) is rare, and characterized by unilateral upper neck or occipital pain and paresthesia in the ipsilateral hemisphere of the tongue due to neck movement. Treatment for NTS is mainly conservative, but the symptoms, causes, and rationale for treatment remain controversial. This study aimed to provide a framework for NTS treatment in clinical practice based on recent treatment directions. Materials and Methods: Case reports published from the past 20 years to August 2021 were searched through MEDLINE, EMBASE, and PEDro databases. Since there is no established management for NTS, the search terms were neck-tongue syndrome and case reports. The Critical Appraisal Checklist for Case Reports was used for the quality assessment of case reports. Through descriptive analysis, NTS symptoms, interventions, and results were reviewed. Results: Among the 16 studies searched, six case reports were selected and analyzed based on eight criteria. Symptoms included neck pain and ipsilateral tongue paralysis when the head was turned. As an intervention, six and four studies showed immediate symptom relief through manual therapy and exercise, respectively. Conclusions: Based on the reviewed evidence, management through physical therapy and chiropractic therapy with conservative methods such as manual therapy and exercise for patients with neck-tongue syndrome is recommended.
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Streeck-Fischer, Annette, Charline Logé, and Simone Salzer. "The Psychoanalytic-Interactional Method (PiM) for Adolescents with Borderline Personality Disorder." Adolescent Psychiatry 10, no. 3 (December 21, 2020): 172–81. http://dx.doi.org/10.2174/2210676610666200327164953.
Повний текст джерелаАнотація:
Background: Studies have shown the practicality of diagnosing borderline personality disorder (BPD) in children from the age of 12 years (cf. ICD-11, DSM-5). Research in the psychodynamic therapy of adolescents with BPD has been rare to date, however, there do exist some studies on the efficacy and effectiveness of psychodynamic therapy in adults with borderline personality disorder. Methods: We adapted the psychoanalytic-interactional method (PiM), originally developed in the treatment of severely disturbed adults, to the conditions of adolescents diagnosed with borderline personality disorder or structural deficits. Randomized controlled trial in an inpatient setting (Salzer et al., 2013; Salzer et al., 2014) showed that PIM is efficacious for adolescents with BPD symptoms. We describe the approach to treatment in detail. Results: The results of the therapeutic study and the short case vignette show that PiM is a useful method in both inpatient and outpatient treatment and meets the specific requirements of adolescent treatment.
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Poulton, James, and Sefi Hassin. "Hate in the service of love: the negative therapeutic reaction revisited in couple therapy." Couple and Family Psychoanalysis 12, no. 2 (October 15, 2022): 149–65. http://dx.doi.org/10.33212/cfp.v12n2.2022.149.
Повний текст джерелаАнотація:
For many years, the negative therapeutic reaction (NTR) was regarded as a form of resistance arising solely in individual psychoanalytic treatment. The possibility, however, that the NTR may also appear in couples has recently emerged as worthy of exploration. After presenting a case in which NTR dynamics predominate, and reviewing analytic literature about the NTR, the authors propose a conceptualisation of a couple-based form of the NTR that relies upon both paradoxical motivations and paradoxical uses of projective and introjective identification. The countertransference reactions these couples tend to induce in therapists will also be explored, and methods for their management will be suggested.
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Timpe, Erin M. "Nephrotoxicity with Combination Vancomycin-Aminoglycoside Therapy." Journal of Pediatric Pharmacology and Therapeutics 10, no. 3 (July 1, 2005): 174–82. http://dx.doi.org/10.5863/1551-6776-10.3.174.
Повний текст джерелаАнотація:
OBJECTIVES The purpose of this paper is to review the medical literature regarding vancomycinaminoglycoside induced nephrotoxicity in the pediatric population. METHODS MEDLINE (1966 through June 2005), EMBASE (1980 through 1st quarter 2005), and International Pharmaceutical Abstracts databases were reviewed using appropriate search terms for articles related to nephrotoxicity with vancomycin and aminoglycoside use. Case reports, letters to editors, retrospective and prospective studies evaluating nephrotoxicity with the agents in pediatric patients were compiled and summarized. Studies in animals and adults were also briefly reviewed. RESULTS One case report, two letters to editors, one retrospective study, and two prospective studies evaluated the nephrotoxicity of combination aminoglycoside and vancomycin therapy in pediatric patients. The collective number of patients in the reports was 165. Patients ranged in age from 3 days to 19 years old. Four out of the six reports, including all of the prospective studies, concluded that combination therapy does not potentiate nephrotoxicity. CONCLUSIONS Although vancomycin and the aminoglycosides have been associated with drug induced nephrotoxicity, reports in the literature do not appear to support the idea that the combination of vancomycin and an aminoglycoside is more nephrotoxic than either medication alone.
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Nwabudike, Lawrence Chukwudi. "Homeopathy as Therapy for Mycosis Fungoides: Case Reports of Three Patients." Homeopathy 108, no. 04 (July 25, 2019): 277–84. http://dx.doi.org/10.1055/s-0039-1687822.
Повний текст джерелаАнотація:
Background Mycosis fungoides (MF) is an uncommon, indolent, form of cutaneous T cell lymphoma, of which there are various types according to international classification. Various treatment modalities are available; however, these are fraught with potentially severe adverse effects. Methods Three cases of immunohistochemically confirmed MF were treated with classical individualized homeopathy. Each case was followed up with photographic documentation and was reported according to the criteria set out in the HOM-CASE guidelines. Based on the WHO-EORTC (World Health Organization–European Organization for Research and Treatment of Cancer) criteria, the patients were classified as T1b, T1a/T1b and T2b respectively. Results All cases remitted following homeopathic treatment and remained in remission. Side effects were not reported in these cases. Conclusions MF may respond to individualized homeopathic medicine. Although the case number here is small, MF is not a common disorder, spontaneous remission is not usually expected, and the disease may progress to a more severe form. Hence, these findings could serve as a basis for further research into the role of individualized homeopathic medicine in the treatment of MF.
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Kim, Hyo Sin, Hye Yeon Park, Young Gun Park, and Minhee Kim. "Primary Intraocular Lymphoma: Case Reports and a Review." Annals of Optometry and Contact Lens 21, no. 2 (June 25, 2022): 53–60. http://dx.doi.org/10.52725/aocl.2022.21.2.53.
Повний текст джерелаАнотація:
Primary intraocular lymphoma is a lymphoma that occurs in the eye, and is a subtype of primary central nervous system lymphoma that occurs in the brain, spinal cord, and meninges. It is composed of diffuse large B cell type. The pathophysiology and cause are not known exactly, and future research is needed. However, viral infection is thought to be the cause in immunocompromised patients. Diagnostic methods include fluorescein angiography, retinal tomography, and ocular magnetic resonance imaging. The main diagnostic method is cytopathology, but due to its false-negative rates the interleukin (IL)-10 cytokine, known as a growth factor for malignant B-lymphocytes in primary intraocular lymphoma, can be helpful in diagnosis. In the case of primary intraocular lymphoma, intravitreal methotrexate injection can be performed. Ratio of IL-10/IL-6 is greater than 1 before treatment and decreases to less than 1 after treatment. Although the prognosis is poor, it is expected to increase the survival rate through research on diagnostic methods and intraocular injection treatment combined with systemic chemotherapy and radiation therapy.
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Ebe, Koji, and Hiroshi Bando. "New era of diet therapy and research including Low Carbohydrate Diet (LCD)." Asploro Journal of Biomedical and Clinical Case Reports 2, S1 (November 15, 2018): 1–3. http://dx.doi.org/10.36502/2019/asjbccr.6143.
Повний текст джерелаАнотація:
The role of this journal, “Asploro Journal of Biomedical and Clinical Case Reports (AJBCCR)” would be providing meaningful information on medical practice and research widely in the world. The word ASPLORO means Research which is coined from the language Esperanto. In the special issue concerning diet therapy, various research and case reports will be expected such as Low Carbohydrate Diet (LCD), Calorie Restriction (CR) Diet, the Mediterranean Diet, and other kinds of methods.
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Ognerubov, Nikolai A., Tatyana S. Antipova, and Elena E. Palkina. "Synchronous thyroid gland metastases from breast cancer. Case reports." Journal of Modern Oncology 23, no. 2 (August 16, 2021): 280–86. http://dx.doi.org/10.26442/18151434.2021.2.200934.
Повний текст джерелаАнотація:
Background. Breast cancer is the leading cause of death in women. Distant metastases in different organs, including the thyroid gland, are still an urgent problem. Distant metastases are very rare in clinical practice. Nevertheless, the accumulated clinical and surgical experience in treatment has shown that breast cancer is the second most common primary tumor, leading to thyroid gland metastases, after kidney cancer.
Aim. Present the clinical observations of synchronous thyroid gland metastases from breast cancer.
Materials and methods. We observed two patients, aged 55 and 72 years, suffering from metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical and mediastinal lymph nodes, to the lungs, to the ovaries and to the bones.
Results. A 55-year-old woman with a left sided neck mass and hoarseness has been suffering from the metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical lymph nodes, to the lungs, to the ovaries and to the bones. The biopsy of the primary tumor has been performed. The tumor has the structure of invasive ductal carcinoma, G2, luminal A subtype, HER2-negative type in histological and immunohistochemical analysis. The spread of the tumor has been determined by positron emission tomography/computed tomography (PET/CT). Metastases from breast cancer have been cytologically proven during thin needle biopsy. A 72-year-old woman with a mass in the region of thyroid gland has been suffering from breast cancer with metastases to the thyroid gland, to the mediastinal and cervical lymph nodes, to the bones, and to determine this process PET/CT, the thyroid fine needle aspiration biopsy and core biopsy of primary tumor have been applied. The histological variant was represented by invasive ductal cancer, G2, luminal A subtype, HER-2 negative type. Taking into account the spread of the process, the patients were given polychemotherapy, targeted therapy and hormone therapy. There is no disease progression for 6 months.
Conclusion. Synchronous thyroid gland metastases in case of primary breast tumors are rare. In such cases, PET/CT is the important diagnostic method. The main therapeutic option in this case is systemic therapy, including chemotherapy, targeted and hormone therapy, the nature of the agent depends on the biological variant of the tumor.
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Nijakowski, Kacper, Patryk Woś, and Anna Surdacka. "Regional Odontodysplasia: A Systematic Review of Case Reports." International Journal of Environmental Research and Public Health 19, no. 3 (February 1, 2022): 1683. http://dx.doi.org/10.3390/ijerph19031683.
Повний текст джерелаАнотація:
Regional odontodysplasia is a rare developmental disorder characterised by hypoplasia and hypomineralisation of enamel and dentin. Our systematic review aimed to organise the knowledge on localisation, symptomatology and treatment methods in patients with regional odontodysplasia based on case reports published in the databases PubMed, Scopus and Web of Science. Case reports were described in 28 different countries, considering 180 patients (including 91 females). Regional odontodysplasia occurs mainly in both deciduous and permanent dentition (66.1%). The affected teeth were observed more frequently in the maxilla (70.0%), especially on the left side (45.6%). The most common reported symptoms were ghost teeth, poorly developed buds, yellowish-brown colour of crowns and delayed eruption of permanent teeth in affected quadrants. The most popular treatment method was surgical treatment (78.6%) with subsequent prosthetic therapy (34.6%). Based on the review of cases, pathognomonic clinical and radiological signs can be found, however, it is difficult to reach a consensus on the choice of treatment method.
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Kaya, M. Siyabend. "The Use of Dynamic Cognitive Behavioural Therapy (DCBT) in Social Anxiety Disorder (SAD): A Theoretical Integration Initiative." Medicina 58, no. 12 (November 30, 2022): 1759. http://dx.doi.org/10.3390/medicina58121759.
Повний текст джерелаАнотація:
Psychotherapy theorists can often become fervent advocates of the schools they follow and place the doctrines of the theories they adopt above all else. This situation can sometimes turn into a war of theories between researchers as well. However, therapists should not aim to shape therapy sessions according to their methods but to use them in line with clients’ needs. Although it is emphasised that the integration of both psychoanalytic and cognitive behavioural therapy techniques, which is going to be named dynamic cognitive behavioural therapy (DCBT) in this case report, will provide more effective and permanent treatment, a discernible gap exists regarding the integration of these theories and their use in psychotherapy. Taking into account this gap, it is considered important to use this approach with a client who has a social anxiety disorder (SAD). Therefore, this study aims to describe the almost forgotten DCBT approach step by step through a case report and reveal the effectiveness of this approach. As a result, DCBT seems to be effective in the treatment of SAD.
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Wang, Shi-Wan, Xiao-Wei Zhang, Jin-Xiu Qu, Yi-Zhong Rao, Shuai Lu, Bing Wang, Jia He, Yuan Zhao, and Ben-Qiang Rao. "Hemolysis attributed to high dose vitamin C: Two case reports." World Journal of Clinical Cases 12, no. 17 (June 16, 2024): 3168–76. http://dx.doi.org/10.12998/wjcc.v12.i17.3168.
Повний текст джерелаАнотація:
BACKGROUND High-dose vitamin C treatment (HVCT) can reduce the adverse effect of chemotherapy and enhance the effect of antitumor therapy, which has been considered one of the safest alternative treatments. However, the severity of its adverse effects may have been underestimated. The most serious adverse effect is hemolysis, which may result in acute kidney injury or death. Although glucose-6-phosphate dehydrogenase (G6PD) deficiency is considered to be the main cause, the probability and pathological mechanism are not completely understood, leading to a lack of effective and standardized treatment methods. CASE SUMMARY Two patients with colorectal cancer developed hemolytic anemia after using 1 g/kg HVCT. In contrast to previous cases, the lowest hemoglobin level in the two cases was < 50 g/L, which was lower than previously reported. This may be because Case 1 had chronic hepatitis B for many years, which caused abnormal liver reserve function, and Case 2 had grade II bone marrow suppression. Both patients improved and were discharged after blood replacement therapy. Our cases had the most severe degree of hemolysis but the best prognosis, suggesting that our treatment may be helpful for rescue of drug-induced hemolysis. This is the first review of the literature on hemolysis caused by HVCT, and we found that all patients with G6PD deficiency developed hemolysis after HVCT. CONCLUSION G6PD deficiency should be considered as a contraindication to HVCT, and it is not recommended for patients with bone marrow suppression, moderate-to-severe anemia, hematopoietic abnormalities, or abnormal liver and kidney function. Early blood purification and steroid therapy may avoid acute kidney injury or death caused by HVCT-related hemolytic anemia.
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Sampayo-Cordero, Miguel, Bernat Miguel-Huguet, Andrea Malfettone, José Manuel Pérez-García, Antonio Llombart-Cussac, Javier Cortés, Almudena Pardo, and Jordi Pérez-López. "The Value of Case Reports in Systematic Reviews from Rare Diseases. The Example of Enzyme Replacement Therapy (ERT) in Patients with Mucopolysaccharidosis Type II (MPS-II)." International Journal of Environmental Research and Public Health 17, no. 18 (September 10, 2020): 6590. http://dx.doi.org/10.3390/ijerph17186590.
Повний текст джерелаАнотація:
Background: Case reports are usually excluded from systematic reviews. Patients with rare diseases are more dependent on novel individualized strategies than patients with common diseases. We reviewed and summarized the novelties reported by case reports in mucopolysaccharidosis type II (MPS-II) patients treated with enzyme replacement therapy (ERT). Methods: We selected the case reports included in a previous meta-analysis of patients with MPS-II treated with ERT. Later clinical studies evaluating the same topic of those case reports were reported. Our primary aim was to summarize novelties reported in previous case reports. Secondary objectives analyzed the number of novelties evaluated in subsequent clinical studies and the time elapsed between the publication of the case report to the publication of the clinical study. Results: We identified 11 innovative proposals in case reports that had not been previously considered in clinical studies. Only two (18.2%) were analyzed in subsequent nonrandomized cohort studies. The other nine novelties (81.8%) were analyzed in later case reports (five) or were not included in ulterior studies (four) after more than five years from their first publication. Conclusions: Case reports should be included in systematic reviews of rare disease to obtain a comprehensive summary of the state of research and offer valuable information for healthcare practitioners.
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Marson, Justin, and Mark Lebwohl. "Apremilast as an Off-Label Therapeutic Agent." SKIN The Journal of Cutaneous Medicine 5, no. 3 (May 17, 2021): 203–27. http://dx.doi.org/10.25251/skin.5.3.2.
Повний текст джерелаАнотація:
Objective: To review the literature regarding the efficacy and safety of off-label use of apremilast in combination therapies for psoriasis and psoriatic arthritis and for other currently off-label inflammatory dermatoses. Methods: The Medline database was queried for all relevant articles published between 2014 and 2021 using exploded MeSH terms and keywords pertaining to the following themes: off-label, combination therapy, biologics, biologic therapy, methotrexate, and systemic psoriasis therapy. The Boolean term “AND” was used to find the intersection of these themes with the term “apremilast.” Results: 8 case series and 6 case reports investigated the use of apremilast in combination therapy for psoriasis and psoriatic arthritis. Addition of apremilast improved PASI scores by 31.8-77.4% among case series and 80-100% among case reports with adverse effects primarily consisting of gastrointestinal symptoms. 5 randomized-control trials (RCT), 9 open-label trials, 18 case series, and 30 case reports investigated the use of apremilast for off-label dermatoses. In RCTs, apremilast showed potential efficacy for atopic dermatitis and hidradenitis suppurativa. Open-label trials found apremilast efficacious for atopic dermatitis, allergic contact dermatitis, chronic pruritus, cutaneous sarcoidosis, discoid lupus erythematosus, hidradenitis suppurativa, lichen planus, prurigo nodularis, rosacea, and vitiligo. Limitations: Small sample size and short follow duration up for available randomized-control and open-label trials. Current data from case series/reports potentially limits generalizability of findings. Conclusion: Apremilast's safety profile makes it a potential efficacious, non-biologic systemic agent for monotherapy and combination therapy for a wide range of inflammatory dermatoses.
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Henley, Lesley D., and Denise M. Frank. "Reporting Ethical Protections in Physical Therapy Research." Physical Therapy 86, no. 4 (April 1, 2006): 499–509. http://dx.doi.org/10.1093/ptj/86.4.499.
Повний текст джерелаАнотація:
Abstract Background and Purpose. Efforts to make physical therapy more evidence based have increased demand for human participants, raising concerns for their safety and welfare. This study examined how often research articles in physical therapy journals report basic ethical protections. Methods. We carried out a retrospective audit of research articles in 6 physical therapy journals between 1996 and 2001. Results. Of 806 articles reviewed, 48% documented both research ethics committee approval and informed consent. Articles reporting clinical interventions had the highest reported rate (64%) of both protections. Articles reporting qualitative methods, chart reviews, and case reports had the lowest rates of documentation of both requirements: 30%, 17%, and 11%, respectively. Reported rates of both requirements in vulnerable populations were 55% for children, 48% for students, and 33% for employees. Twenty-six percent of articles included confidentiality assurances. Case reports were most likely and chart reviews were least likely to mention confidentiality: 88% and 8%, respectively. Discussion and Conclusion. There is no uniform editorial policy among physical therapy journals for reporting basic ethical requirements. Physical therapy journals should standardize ethical protections and make documentation of compliance a prerequisite of publication. [Henley LD, Frank DM. Reporting ethical protections in physical therapy research.
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Orsolini, L., S. Tempia Valenta, S. Bellagamba, V. Salvi, and U. Volpe. "Clozapine-Treatment-Resistant Schizophrenia Successfully Managed with Brexpiprazole Combination Therapy: Two Case Reports." European Psychiatry 65, S1 (June 2022): S355—S356. http://dx.doi.org/10.1192/j.eurpsy.2022.903.
Повний текст джерелаАнотація:
Introduction Clozapine has proven to have a unique efficacy on treatment-resistant schizophrenia (TRS). Nevertheless, studies show that 47%-63% of clozapine-treated patients may fail to respond after around 12-years of treatment (CRS). Several augmentation strategies have been proven to be effective in CRS. Objectives Hereby, we present two clinical cases of CRS successfully managed with brexpiprazole augmentation. Methods A 48-year-old man without comorbid substance use, treated with clozapine-brexpiprazole augmentation, and a 20-year-old man with comorbid substance use, treated with clozapine-brexpiprazole combination and subsequently with twice-injection aripiprazole (TIA). They were administered with the following assessments at t0, t1-3 (first month), t4-8 (monthly until 6-month follow-up): CGI, BPRS, PANSS, CDSS, Craving VAS, BARS, BIS-11, HRS-A, MADRS, YMRS, AIMS. Results At 1-month follow-up, both patients showed a considerable improvement (respectively 75% and 55.9% reduction of PANSS total score). At 6-month follow-up, reached only with the first patient, we noticed a further improvement (an overall 37.5% reduction of PANSS total score from the baseline). Conclusions The present work is the first report describing combination treatment strategies with clozapine and brexpiprazole which appear to give promising results. Disclosure No significant relationships.
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Fukui, Hiroki, Naosuke Kamei, Yasushi Fujiwara, Toshio Nakamae, Ryo Ohta, Shinji Kotaka, and Nobuo Adachi. "Intradiscal Condoliase Injection Therapy for Recurrent Lumbar Disc Herniation: Case Series and Literature Review." Medicina 59, no. 9 (August 28, 2023): 1561. http://dx.doi.org/10.3390/medicina59091561.
Повний текст джерелаАнотація:
Background and objectives: Although chemonucleolysis with condoliase for lumbar disc herniation (LDH) has become common, few reports have described its application in the treatment of recurrent LDH. Therefore, this study aimed to evaluate the safety and efficacy of condoliase treatment in six patients with recurrent LDH and review the available literature on condoliase treatment for LDH. Materials and Methods: Six patients (four men and two women; mean age, 64.7 years) with recurrent LDH who were treated with condoliase at our hospital between 2019 and 2022 were included. The clinical records and images of the patients were retrospectively evaluated. In addition, the available English literature on condoliase treatment for LDH was retrieved and reviewed. Results: Among the six patients included in the study, three showed >50% improvement in leg pain after treatment, which is a lower efficacy rate than that in previous reports. In addition, two patients required surgery after treatment, which is a higher rate than that in previous reports. The mean intervertebral disc height significantly decreased from 8.4 mm before treatment to 6.9 mm after treatment, consistent with the results of previous studies. None of the cases showed Modic type I changes on magnetic resonance imaging. Conclusions: Although the efficacy of condoliase treatment for recurrent LDH may be lower than that for primary LDH, this treatment was found to be safe and applicable for recurrent LDH.
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Krutova, V. A., I. E. Aslanyan, A. I. Tulendinova, and N. V. Naumova. "Acute Gynaecological Conditions in Adolescents. Challenges with Differential Diagnosis (Case Reports)." Doctor.Ru 21, no. 1 (2022): 46–53. http://dx.doi.org/10.31550/1727-2378-2022-21-1-46-53.
Повний текст джерелаАнотація:
Objective of the Paper: To demonstrate possible challenges with differential diagnosis of adenomyosis and abnormal uterus development in practical paediatric gynaecology. Key Points. We presented two cases of teenage girls with similar clinical symptoms in various diseases: nodular adenomyosis, which is rare for adolescents, and abnormal uterus development. Despite a full range of clinical and instrumental examinations (MRI, ultrasound examinations), it is only laparoscopy that allowed identifying the cause of pain. Conclusion. It is advisable to active use minimally invasive surgical procedures in paediatric inpatient units. Clinical recommendations and medical aid procedures for this urgent pathology are required to facilitate decision-making by medical professionals to apply endosurgical methods of therapy. Keywords: paediatric gynaecology, pain syndrome, differential diagnosis, adenomyosis, abnormal uterus development.
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Azevedo, F., R. André, I. Donas-Boto, D. Jeremias, and C. Almeida. "Electroconvulsive therapy for Depression in Anorexia Nervosa. A review." European Psychiatry 65, S1 (June 2022): S738. http://dx.doi.org/10.1192/j.eurpsy.2022.1906.
Повний текст джерелаАнотація:
Introduction Anorexia nervosa has an important burden on both patients and families, with important comorbidities such as depression and obsessive symptoms. These are more resistant to pharmacological treatment than in non-anorexia patients, due to both biological and psychological mechanisms. Electroconvulsive therapy is the best available therapy for treatment resistant depression making it a treatment to consider in treatment resistant depression in anorexia though only case reports exist. Objectives To review the current evidence for electroconvulsive therapy of depression in patients with anorexia nervosa as well as it’s ethical challenges Methods Non-systematic review of the literature with selection of scientific articles published in the past 10 years; by searching Pubmed and Medscape databases using the combination of MeSH descriptors. The following MeSH terms were used: “electroconvulsive therapy”, “anorexia nervosa”. Results Electroconvulsive therapy in anorexia has no controlled trials with mostly case reports available on scientific databases. It presents important challenges due to patient age, medical status and ethical challenges. Even less evidence exist for electroconvulsive therapy in children and adolescents than for adults, anorexia can complicate medical status presenting an anesthetic and life-support challenge and it’s egosyntonicity can place a legal and ethical challenge when patient refuses treatment. Conclusions Anorexia has a dramatic burden on patients and families affected, with integrated evidence-based treatment being necessary both for treating the current episode and for remission prevention. Case-reports show that electroconvulsive therapy can play a role on treatment resistant depression in anorexia. Disclosure No significant relationships.
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Yuan, Chi. "Acute ST-segment elevation myocardial infarction after intravenous thrombolysis in acute cerebral infarction: A case report and Literature review." Clinical Imaging and Case Reports 5, no. 1 (September 27, 2022): 1–5. http://dx.doi.org/10.52338/cicasrep.2022.1007.
Повний текст джерелаАнотація:
Acute ischemic stroke is a common emergency in neurology. At present, there are two common treatment methods, intravenous thrombolysis and transcatheter mechanical thrombectomy. However, there are few reports of acute myocardial infarction after intravenous thrombolysis with Alteplase(rt-PA). However, the pathogenesis of acute myocardial infarction after thrombolysis and its relevance to thrombolytic therapy are still unclear. This article combines case reports to illustrate its possible pathogenesis and review of related literature.
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Tesař, Jan, Martin Šín, Pavel Němec, and Jan Studnička. "Diagnoses That Mimic Pachychoroid Diseases of the Macula – Case Reports." Czech and Slovak Ophthalmology 77, no. 1 (March 11, 2021): 36–44. http://dx.doi.org/10.31348/2021/x04.
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Pachychoroid disease of retina is a spectrum of diseases manifested by thickening and hyperperfusion of the choroid with changes in the sensory part of the retina. The main unit of this group is central serous chorioretinopathy (CSC). In practice, we often encounter other conditions, which are manifested by thickening of the choroid and changes in the retina, but they cannot be classified as pachychoroid diseases. The aim of this study is to point out on a series of 3 case reports the difficulties in the differential diagnosis of retinal diseases in which we find thickening of the choroid. Case report 1: 42-year-old patient treated for central serous chorioretinopathy. After optical coherence tomography (OCT), fluorescence angiography (FAG) and indocyanine green angiography (ICG) the diagnosis was changed to choroidal hemangioma and he was treated with photodynamic therapy (PDT) which led to a reduction of the hemangioma. Case report 2: A 30-year-old patient treated for ankylosing spondylitis comes for visual impairment in the left eye. On OCT the condition resembled chronic CSC. The patient suffered from a febrile exanthema a few days ago. Serological testing for coxsackievirus was positive and the diagnosis was changed to acute chorioretinitis in coxsackievirus infection. Oral treatment with prednisone was successful. Case report 3: A 46-year-old patient was treated conservatively for CSC. After FAG and ICG, a solitary dilated choroidal vessel was found in the area of the papillomacular bundle with leakage under the sensory epithelium which was diagnosed as choroidal macrovessel. We performed PDT with a very good anatomical effect. Conclusion: Precise differentiation of these mentioned diseases from pachychoroid retinal diseases was essential in choosing the appropriate therapy. The use of all modern imaging methods of the retina and choroid plays a key role in determining the diagnosis.
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O’Brien, Amber, and Schaida Schirwani. "SG13 Managing cutaneous manifestations of FH-associated tumour predisposition syndrome: a systematic review of case reports." British Journal of Dermatology 191, Supplement_1 (June 28, 2024): i187. http://dx.doi.org/10.1093/bjd/ljae090.395.
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Abstract The cutaneous manifestations of fumarate hydratase (FH)-associated tumour predisposition syndrome, otherwise called hereditary leiomyomatosis and renal cell carcinoma (HLRCC), can be managed in a variety of ways including surgical excision, oral and topical analgesia, laser therapy and cryotherapy. While some of these methods are considered well established, others are less widely used and there is little evidence reported comparing the outcomes after treatment. This systematic review of case reports aims to determine how symptom burden after surgical excision of the cutaneous lesions differs from symptom burden after analgesic treatment or other methods. The databases OVID MEDLINE, Embase and Scopus were searched with terms such as ‘HLRCC’, ‘cutaneous’, ‘leiomyoma’ and ‘management’. In total, 19 case reports with a total of 23 patients diagnosed with HLRCC and cutaneous manifestations, for example leiomyomas, were included in this systematic review. These case reports were dated between 2009 and 2022. Eleven of these patients had their cutaneous lesions treated with surgical excision, eight were treated with analgesia and nine were treated with ‘other methods’. ‘Other methods’ was defined as any treatment that was not surgical or simple analgesia, and included carbon dioxide laser therapy, erbium laser therapy, liquid nitrogen cryotherapy, phototherapy, botulinum toxin, electrocoagulation, and immunosuppression with azathioprine. Some patients were treated with a combination of methods. Surgical excision showed the poorest symptom outcomes after treatment, with 9% of patients showing improvement of symptom control after treatment compared with 75% of patients having symptom improvement with analgesic treatment and 89% after ‘other methods’. When surgical excision was combined with analgesia or ‘other methods’, symptom control was improved compared with surgical excision when used alone. This review shows that surgical excision may not provide optimal symptom control for patients with cutaneous manifestations of HLRCC, and other treatments should be considered. Surgical excision of cutaneous lesions allows histopathological confirmation of leiomyomata and therefore has an important role in the diagnosis of HLRCC, so it should not be excluded from treatment recommendations. However, clinicians should consider combining excision with another treatment, for example analgesia with agents such as gabapentin. Further research in the form of a large cohort study or randomized control trial is necessary to confirm the observations made by this systematic review by providing more quantitative data.
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Tate, Robyn L., Michael Perdices, Ulrike Rosenkoetter, William Shadish, Sunita Vohra, David H. Barlow, Robert Horner, et al. "The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement." Physical Therapy 96, no. 7 (July 1, 2016): e1-e10. http://dx.doi.org/10.2522/ptj.2016.96.7.e1.
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AbstractWe developed a reporting guideline to provide authors with guidance about what should be reported when writing a paper for publication in a scientific journal using a particular type of research design: the single-case experimental design. This report describes the methods used to develop the Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016. As a result of 2 online surveys and a 2-day meeting of experts, the SCRIBE 2016 checklist was developed, which is a set of 26 items that authors need to address when writing about single-case research. This article complements the more detailed SCRIBE 2016 Explanation and Elaboration article (Tate et al., 2016) that provides a rationale for each of the items and examples of adequate reporting from the literature. Both these resources will assist authors to prepare reports of single-case research with clarity, completeness, accuracy, and transparency. They will also provide journal reviewers and editors with a practical checklist against which such reports may be critically evaluated. We recommend that the SCRIBE 2016 is used by authors preparing manuscripts describing single-case research for publication, as well as journal reviewers and editors who are evaluating such manuscripts.Scientific AbstractReporting guidelines, such as the Consolidated Standards of Reporting Trials (CONSORT) Statement, improve the reporting of research in the medical literature (Turner et al., 2012). Many such guidelines exist and the CONSORT Extension to Nonpharmacological Trials (Boutron et al., 2008) provides suitable guidance for reporting between-groups intervention studies in the behavioral sciences. The CONSORT Extension for N-of-1 Trials (CENT 2015) was developed for multiple crossover trials with single individuals in the medical sciences (Shamseer et al., 2015; Vohra et al., 2015), but there is no reporting guideline in the CONSORT tradition for single-case research used in the behavioral sciences. We developed the Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 to meet this need. This Statement article describes the methodology of the development of the SCRIBE 2016, along with the outcome of 2 Delphi surveys and a consensus meeting of experts. We present the resulting 26-item SCRIBE 2016 checklist. The article complements the more detailed SCRIBE 2016 Explanation and Elaboration article (Tate et al., 2016) that provides a rationale for each of the items and examples of adequate reporting from the literature. Both these resources will assist authors to prepare reports of single-case research with clarity, completeness, accuracy, and transparency. They will also provide journal reviewers and editors with a practical checklist against which such reports may be critically evaluated.Keywords: single-case design, methodology, reporting guidelines, publication standardsSupplemental materials: http://dx.doi.org/10.1037/arc0000026.supp
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Suzuki, Masao, Yoko Yokoyama, and Hiroshi Yamazaki. "Research into Acupuncture for Respiratory Disease in Japan: A Systematic Review." Acupuncture in Medicine 27, no. 2 (June 2009): 54–60. http://dx.doi.org/10.1136/aim.2009.000471.
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Background In Japan, studies on acupuncture therapy for respiratory disease have rarely been reported. Additionally, most of the reports are difficult for overseas researchers to access because they are written in Japanese and cannot be located using Medline. Purpose To review studies on acupuncture and moxibustion therapy for respiratory disease conducted in Japan. Data sources The results of a literature search using “Igaku Chuo Zasshi Web” and the Medical Online Library, both of which are Japanese databases, covering the period between 1979 and 2006. Study selection This study reviewed references cited in retrieved documents and selected original articles and case reports on acupuncture and moxibustion therapy for respiratory disease. Data extraction The search terms used were “acupuncture” and “respiratory disease”, along with “respiratory”, “asthma”, “COPD”, “bronchitis” and “common cold”. Results The study retrieved 34 papers on acupuncture treatment for respiratory disease written in Japanese (9 full papers, 19 case reports and 6 case series). The papers dealt with such conditions as asthma (14 trials), cough variant asthma (one trial), chronic obstructive pulmonary disease (seven trials), chronic bronchitis (one trial), usual/idiopathic interstitial pneumonia (one trial) and the common cold (two trials). The study also found eight trials dealing with cold prevention. Conclusions A small number of reports on acupuncture and moxibustion treatment for respiratory diseases were found in the Japanese databases. Future studies must use more rigorous evaluation methods, such as randomised controlled trials, to measure the effectiveness of acupuncture and moxibustion therapy for treating respiratory diseases.
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Bianchi, Angela. "Il caso clinico di Martha N.: Sabine Spielrein e un primo esempio di analisi del linguaggio schizofrenico." CHIMERA: Revista de Corpus de Lenguas Romances y Estudios Lingüísticos 9 (July 31, 2022): 289–320. http://dx.doi.org/10.15366/chimera2022.9.013.
Повний текст джерелаАнотація:
The present work aims to provide an analysis of the method used by Sabina Spielrein as a pioneering attempt at research on pathological language, in a historical moment in which the treatment of the disease was faced in an experimental way both in the methods and in the results. The psychological content of a case of schizophrenia (dementia praecox) is the first psychoanalytic dissertation written by a woman, one of the first interpretative accounts of schizophrenia and one of the first works in which the term schizophrenia is used. The subject of the thesis is the clinical case of Martha N., a woman suffering from schizophrenia of which Spielrein took care of observing the underlying language and apparently senseless of schizophrenic pathology by applying the “phylogenetic observation method”, with which he grasped the present parallelism between the mental activity typical of schizophrenics, the psychological process of dreams and the mythological thought to which the “mythological language” is associated. Spielrein reports in her work excerpts from the speeches of the sessions held with her patient: this is a valuable document that testifies to one of the first attempts to investigate pathological language.
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Neferu, Ramona, Ricardo Viana, Tom Miller, and Michael Payne. "Botulinum toxin therapy in amputee pain management." University of Western Ontario Medical Journal 87, no. 1 (April 24, 2018): 42–45. http://dx.doi.org/10.5206/uwomj.v87i1.1931.
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Background: Post-amputation pain is common, occurring in up to 85% of patients. The pain can be related to the etiology of amputation, post-surgical healing, or prosthetic use. Pain syndromes may arise from a variety of tissue pathologies and can be broadly categorized into residual limb pain (RLP) or phantom limb pain (PLP). Botulinum toxin (BTX) has been found to be effective in treating a variety of neuropathic pain conditions. This scoping review summarizes the use of BTX in RLP and PLP management of patients with a major extremity amputation.
Methods: A literature search was conducted using PubMed, Web of Science, Cochrane Library, Scopus, and Google Scholar. Sixteen studies were included. Most studies excluded did not address BTX use in amputee pain management. Extracted data were categorized by either RLP or PLP.
Results: Two randomized controlled trials (RCTs), 10 case series, and 4 case reports were included (total 68 patients, 82 amputations). Seven studies addressed BTX use in both RLP and PLP, 5 studies address RLP exclusively, and 5 additional studies exclusively addressed PLP. Toxin types, injection techniques, and dosages varied between the studies. Negative results were reported in 2 RCTs and 2 case series showing 30% of patients with RLP and 50% patients with PLP did not benefit from BTX.
Conclusion: Literature for BTX in PLP and RLP is broad but lacking rigour for definitive conclusions to guide usage. There were more positive results for BTX use in RLP than in PLP. Case reports and patient series show promising results for both PLP and RLP, indicating future research should be directed at adequately-powered prospective trials.
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Ząbkowska, Ewelina, Olga Czerwińska-Ledwig, Magdalena Bartnicka, and Anna Piotrowska. "Case Reports and Experts Opinions about Current Use of Leech Therapy in Dermatology and Cosmetology." Cosmetics 9, no. 6 (December 9, 2022): 137. http://dx.doi.org/10.3390/cosmetics9060137.
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This article aimed to determine the experts’ opinion on the use of hirudotherapy in cosmetology, to supplement knowledge, and to identify factors that, in the opinion of experts, affect the effectiveness and frequency of use of this method in eliminating skin problems. The study was conducted using the expert interview method. The research tool was a categorized expert interview questionnaire using the CAWI (Computer Assisted Web Interview) technique. Hirudotherapy is one of the oldest healing methods. The mechanism of action is based on the therapeutic properties of bioactive substances isolated from leech saliva. It has been shown to have a wide range of applications in the treatment of numerous diseases in various fields of medicine, including dermatology and cosmetology. Despite its therapeutic properties and effectiveness, hirudotherapy is a rarely used tool in cosmetology. It has been found effective in the treatment of many dermatoses. The most spectacular effects have been observed in the treatment of rosacea, local inflammations, lipomas, skin scars, hard to heal wounds and contusions.
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Eliaz, Isaac, and Elaine Weil. "Intravenous Honokiol in Drug-Resistant Cancer: Two Case Reports." Integrative Cancer Therapies 19 (January 2020): 153473542092261. http://dx.doi.org/10.1177/1534735420922615.
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Context: Long-term patient survival in cancer is affected by drug resistance. Honokiol (HNK) is a small-molecule polyphenol isolated from the bark and seed cones of Magnolia officinalis. HNK has been shown to enhance the effects of chemotherapy and inhibit drug resistance in preclinical models. HNK was well tolerated in multiple animal models when administered orally, intravenously (IV), and via intraperitoneal route. However, there are limited human data on the use of HNK in general, and specifically via IV (HNK-IV) in cancer. Objective: We aim to assess the efficacy, safety, and tolerability of HNK-IV in patients with drug-resistant tumors. Methods: This is a case study of 2 cancer patients who utilized HNK-IV as part of their cancer treatment regimen. The initial infusion of HNK was 10 mg/kg body weight, and subsequent treatments were increased up to 50 mg/kg according to individual tolerance, over 2 weeks. Results: Positive clinical response was achieved in both patients, including improved symptoms and quality of life. No serious adverse side effects occurred, and there were no adverse effects on laboratory parameters (complete blood count, kidney, and liver function). Transient sedation and minor nausea were noted and resolved postinfusion. Conclusions: This is the first report of HNK-IV in human patients. Given the positive clinical results, safety, and tolerability, the use of HNK-IV warrants further investigation regarding optimum formulation, and its use as adjunctive therapy in cancer patients.
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Antonijevic, Nebojsa, Tatjana Terzic, Vesna Jovanovic, Nada Suvajdzic-Vukovic, Rajko Milosevic, Nada Basara, and Ivo Elezovic. "Acquired amegakaryocytic thrombocytopenia: Three case reports and a literature review." Medical review 57, no. 5-6 (2004): 292–97. http://dx.doi.org/10.2298/mpns0406292a.
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Introduction Acquired amegakaryocytic thrombocytopenia (AAT) is a rare disease characterized by thrombocytopenia due to selective reduction/absence of bone marrow (BM) megakaryocytes. In the BM culture isolated reduction of colony-forming units-megakaryocyte (CFU-Mk) may occur. Material and methods BM aspirates and trephine biopsies were obtained from all patients and processed by routine methods. In vitro BM culture and cytogenetic analysis was performed in one patient. Results This article presents three patients with manifested signs of hemorrhagic syndrome due to severe thrombocytopenia caused by an absence/significant reduction of BM megakaryocytes. Eexistence of systemic or any other disease was excluded in all patients. BM culture of the second patient showed reduction of all hematopoietic progenitors. In the subsequent course of the disease in this patient, signs of dysplastic erythrocytic series and megakaryocytes were also noted, although there were no positive proofs of evolution into myelodysplastic syndrome. Discussion AAT is a disease of hematopoietic stem cells manifesting in a certain period as amegakaryocytic thrombocytopenia which subsequently may progress into aplastic anemia or myelodysplastic syndrome. Patients were treated with corticosteroids, lithium carbonate, androgens, vincristine, immunoglobulins, folic acid, platelet and erythrocyte transfusions along with plasma substitution. The first patient reacted positively to the therapy. In two other patients a minimal, short-term therapeutic effect was achieved, followed by improvement of hemorrhagic syndrome and an insignificant increase in platelet count. In one patient the treatment was stopped after 4 months and the other died of bleeding after 4 months. Conclusion AAT is a rare disease with unpredictable course. This is a case report of three patients with AAT and different therapeutic effects.
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Khalayli, Naram, Ghina Haider, Yara Hodifa, Maysoun Kudsi, and Nada Naman. "Ocular manifestations in COVID-19 infections: a case series." Annals of Medicine & Surgery 85, no. 11 (September 18, 2023): 5309–13. http://dx.doi.org/10.1097/ms9.0000000000001305.
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Introduction: The prevalence of ocular abnormalities of COVID-19 is different according to different reports. However, currently available evidence on the presence of this virus in ocular secretions and its association with conjunctivitis is not well established. Objective: To reveal the ocular features among COVID-19 patients and to describe them with the findings of clinical data, inflammatory markers, and respiratory support therapy. Methods: Ocular symptoms were evaluated and recorded in 494 COV19 patients through questionnaire-style interviews, and an ophthalmologic examination. Data including age, sex, disease severity, and nasopharyngeal swab results were collected. Laboratory test values were reviewed. Patients with COVID-19 infections were classified into severe cases and mild cases. Results: The prevalence of ocular features was (2.83%). The most common features were conjunctival hyperaemia, epiphora, and foreign body sensation with itching. Patients with ocular manifestations on CPAP support therapy had higher rates of itching, lower rates of foreign body sensation. No differences were found in the levels of inflammatory marker. Meanwhile, patients used respiratory-aid therapy revealed higher values of white blood cells, platelet counts, erythrocyte sedimentation rate, C-reactive protein, ferritin, and lactate dehydrogenase. Discussion: Ocular involvement in COVID-19 and possibility of disease transmission through ocular tissues and secretions, has been registered in some reports, with a prevalence of 2–32%. The external and internal ocular parts are involved. Conclusion: Ocular features are not infrequent in COVID-19 patients.
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Routhouska, Shannon B., Pranav B. Sheth, and Neil J. Korman. "Long-Term Management of Generalized Pustular Psoriasis with Infliximab: Case Series." Journal of Cutaneous Medicine and Surgery 12, no. 4 (July 2008): 184–88. http://dx.doi.org/10.2310/7750.2008.07036.
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Background: Infliximab, a tumor necrosis factor α antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports. Objective: The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab. Methods: Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab. Results: Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate. Conclusion: Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.
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Givtaj, Nader, Elnaz Hosseinzadeh, Fatemeh Shima Hadipourzadeh, Zahra Faritous, Mohammad Hasan Askari, and Maryam Ghanbari Garekani. "Goal-directed therapy in cardiovascular surgery: A case series study." Journal of Cardiovascular and Thoracic Research 15, no. 3 (September 23, 2023): 186–92. http://dx.doi.org/10.34172/jcvtr.2023.31838.
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Hemodynamic and intravascular volume monitoring has been utilized and significantly improved thanks to the technology revolution. Goal-Directed Therapy (GDT) derived from this advanced monitoring is beneficial for complex surgeries, and it shifted the medical approaches from static therapy to more personalized functional treatments. Conventional monitoring methods such as blood pressure, heart rate, urinary output, and central venous pressure are commonly used. However, studies have shown these routine parameters often cannot precisely estimate the quality of tissue perfusion. Tissue hypoperfusion and hypoxia play a crucial role in initiating a systemic inflammatory response after prolonged surgeries, resulting in unstable hemodynamic condition of the patients. Several studies reported the importance of GDT in non-cardiac surgeries and there are few reports on cardiac surgeries. However, tissue perfusion and fluid management are more critical in complex and prolonged cardiovascular surgeries to avoid complications such as low cardiac output syndrome and renal or pulmonary dysfunction. Different advanced hemodynamic monitorings have been utilized perioperatively in cardiac surgery to help decision-making on inotrope and fluid management. In this article we present 5 cases of usefulness hemodynamic monitoring in patients who underwent cardiovascular surgeries.
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Hester, Anna, Franziska Henze, Christiane Travi, Nadia Harbeck, and Rachel Wuerstlein. "First Experiences with Alpelisib in Clinical Routine: Case Reports from a German Breast Center." Breast Care 16, no. 2 (2021): 129–34. http://dx.doi.org/10.1159/000514794.
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<b><i>Introduction:</i></b> The phosphatidylinositol-3-kinase (PI3K) inhibitor alpelisib is the only approved agent for treating <i>PIK3CA</i>-mutated, hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer (ABC). Trials have reported hyperglycemia, diarrhea, and rash as the main grade 3 side effects. <b><i>Methods:</i></b> In a managed access program (ClinicalTrials.gov ID: NCT03706573; start: 06/2019), 8 HR+ HER2– ABC patients with a median 4.5 prior therapy lines were treated with alpelisib at the Breast Center of the Ludwig-Maximilian University (LMU) Hospital, Munich, based on the results of a new-generation sequencing (NGS) panel and <i>PIK3CA</i> mutation analysis by the Molecular Tumor Board of the Comprehensive Cancer Center, Munich. <b><i>Results:</i></b> Median therapy duration was 3.42 months for patients who discontinued and 3.95 months for those still on alpelisib (4 pts). Five had hyperglycemia (1 with grade 3) with fasting glucose levels of up to 450 mg/dL that required hospitalization and insulin therapy. Two experienced rash (grades 1 and 3) and 2 reported grade 3 diarrhea. Supportive therapy as well as interruption and/or dose reduction were necessary to control treatment-associated side effects. <b><i>Conclusion:</i></b> Patient education and a well-trained, interdisciplinary team including diabetologists, from the initiation of alpelisib treatment onwards, are essential to safely treat ABC patients with this new drug and to maintain their quality of life and ensure their survival.
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Bulić, Kresimir, Eva Brenner, Luka Bulić, Mia Lorencin Bulić, and Hrvoje Kisić. "Combination of cable ties and barbed sutures for fasciotomy closure – two case reports." Acta Chirurgiae Plasticae 65, no. 3-4 (March 25, 2024): 147–49. http://dx.doi.org/10.48095/ccachp2023147.
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While fasciotomy is the only urgent treatment option for compartment syndrome, the resulting open wound leaves room for complications. Closure of the wound can be done by different techniques, including split-thickness skin grafts, negative pressure therapy, an absorbable barbed suture system and a cable ties system. The aim of this paper is to demonstrate how a combined application of these methods can reduce their respective individual disadvantages. Our combined method was tried in two patients, one with an open tibial fracture and the other who underwent ulnar nerve reparation. Both patients started exhibiting signs of compartment syndrome within 3 hrs after surgery. Firstly, absorbable barbed suture systems were positioned with the running intradermal technique. Following this the cable ties were inserted and the limb in question was placed in an elevated position. Complete closure of the patient’s wounds was achieved within 2 weeks without complications. This result is a testament to the added benefit of a combination of these methods in comparison with the results they produce individually.
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Papathemeli, Despoina, Ronald Gräfe, Uwe Hildebrandt, Uwe K. Zettl, and Jens Ulrich. "Development of a primary cutaneous CD30(+) anaplastic large-cell T-cell lymphoma during treatment of multiple sclerosis with fingolimod." Multiple Sclerosis Journal 22, no. 14 (July 11, 2016): 1888–90. http://dx.doi.org/10.1177/1352458516645868.
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Background: The appearance of solid tumors und lymphomas during treatment with fingolimod was observed in studies and has been described in case reports. Objective: To report a case of primary cutaneous CD30(+) anaplastic large-cell T-cell lymphoma during treatment of multiple sclerosis (MS) with fingolimod. Methods: Case study. Results: Our patient developed a lymphoma a few weeks after initialization of therapy with fingolimod; 5 weeks after discontinuation of treatment the lesions resolved. Conclusion: Causality of fingolimod is indicated by the fact that the skin lesions appeared after commencement of treatment and resolved after discontinuation of therapy. This case serves as a reminder of the potential side effects of fingolimod.
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Doğan, Demet, and Nazlı Uçar. "Haglund's Disease with Clinical and Radiological Findings: 3 Case Reports." Medical Science and Discovery 10, no. 6 (June 24, 2023): 421–25. http://dx.doi.org/10.36472/msd.v10i6.956.
Повний текст джерелаАнотація:
Objective: Haglund's Deformity is a variation of the posterosuperior region enlargement of the Os Calcaneus (OC) in the form of exostosis. It is associated with Haglund's Disease (HD), which encompasses Achilles tendinitis, retrocalcaneal bursitis, supra calcaneal bursitis, and inflammation of the Kager fat pad. Diagnosis is based on clinical findings and radiological methods, such as lateral ankle radiographs, Computed Tomography (CT), and Magnetic Resonance Imaging (MRI). This study aims to present three cases of ankle pain diagnosed with HD using radiological imaging. The mean age of our cases was 44.6 years, with two females and one male. Patients commonly present with complaints of pain and swelling behind the heel. Results: Physical examination revealed pain and tenderness upon palpation over the left OC and Achilles tendon insertion. Radiological examination showed osseous protrusion in the posterosuperior part of the OC, indicating Haglund's Deformity. Edema was observed at the bony prominence of the posterosuperior OC, Kager fat pad, and heel area. The treatment plan for all three patients included leg rest splint, anti-inflammatory medication, and physical therapy. Conclusion: In cases of heel pain where traumatic events such as acute fractures are ruled out, MRI should be performed, and Haglund's Syndrome should be investigated if osseous protrusion in the posterosuperior calcaneus is observed on radiographs, along with other findings suggestive of HS.
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Constantin, Alexandru, Daniela Năstase, Delia Tulbă, Paul Bălănescu, and Cristian Băicuș. "Immunosuppressive therapy of systemic lupus erythematosus associated peripheral neuropathy: A systematic review." Lupus 29, no. 12 (August 5, 2020): 1509–19. http://dx.doi.org/10.1177/0961203320948181.
Повний текст джерелаАнотація:
Introduction Peripheral neurologic manifestations may be associated with most of the collagen vascular diseases including systemic lupus erythematosus (SLE), yet most of the times it is not clear what therapy should be prescribed. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations suggest the use of glucocorticoids and immunosuppressive agents for the treatment of SLE associated peripheral neuropathy (PN) (strength of statement A, category of evidence 1), however these recommendations are based on studies that did not focus specifically on PN but rather on neuropsychiatric manifestations of SLE out of which only one was a randomized controlled clinical trial that included 7 patients with peripheral neuropathy. The objective of this systematic review is to determine whether the pathogenic treatments (corticosteroids, immunosuppressive agents, intravenous immunoglobulins, plasmapheresis) are effective for SLE associated PN. Methods We searched MEDLINE for all the studies that included the pathogenic treatment of SLE associated PN. The purpose was to identify randomized clinical trials, and in the absence of these, we included observational studies and case reports or case series. Results The search returned only retrospective case reports or case series. Only one prospective study, a randomized controlled study, was focused on neuropsychiatric SLE and included few patients with PN (7). Some studies reported cases of PN responsive to glucocorticoids (GC), cyclophosphamide (CYC), rituximab (RTX), azathioprine (AZA), plasmapheresis (PPH), intravenous immunoglobulin (IVIG), mycophenolate mofetil (MMF) or different combinations of these immunosuppressive agents, whereas others noticed effectiveness of sequential treatments (i.e. administration of a therapeutic agent after another single agent or a combination of agents had previously failed). Many studies did not mention how the outcomes were objectively measured. Conclusions There are no interventional studies dedicated to the SLE associated PN, only retrospective case reports or case series which not only did they show contradictory results, but they also represent the lowest level of evidence. There is a strong need for new analytical studies dedicated to SLE associated PN. Protocol registered with PROSPERO (number CRD42019121748).
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Halverstam, Caroline P., Joshua Zeichner, and Mark Lebwohl. "Lack of Significant Skeletal Changes after Long-Term, Low-Dose Retinoid Therapy: Case Report and Review of the Literature." Journal of Cutaneous Medicine and Surgery 10, no. 6 (November 2006): 291–99. http://dx.doi.org/10.2310/7750.2006.00065.
Повний текст джерелаАнотація:
Background: Long-term systemic retinoid therapy has been associated with skeletal side effects. There have been reports of diffuse idiopathic skeletal hyperostosis (DISH) syndrome, calcification of ligaments, and osteoporosis, as well as premature fusion of epiphyses and modeling abnormalities of long bones, occurring in patients on chronic high-dose isotretinoin, etretinate, and acitretin therapy. Low-dose acitretin has been used for many years as monotherapy or in combination with other systemic therapies for psoriasis. Evidence to date suggests that the frequency of symptomatic bony effects is quite low in these patients. Objective: To present the radiologic findings of a patient on long-term, low-dose acitretin and etretinate and to review the literature on the radiologic evidence of skeletal side effects during retinoid therapy. Methods: Case report and literature search. Results: A patient on low-dose acitretin had no significant radiologic abnormalities associated with retinoid use after 9 years of treatment. A review of the literature revealed conflicting reports on the incidence of radiologic abnormalities in patients on retinoid treatment. Conclusion: The evidence to date does not substantiate a clear link between radiologic skeletal abnormalities and long-term, low-dose acitretin or etretinate therapy.
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Simin, Dragana, Dragana Milutinović, Vesna Turkulov, and Svetlana Simić. "Peripheral nerve injury related to peripheral intravenous therapy." Inspirium, no. 14 (2015): 19–21. http://dx.doi.org/10.5937/insp1513019s.
Повний текст джерелаАнотація:
Introduction: The objective of the current study was to present data on peripheral nerve injury related to peripheral intravenous therapy obtained through the use of empirical studies and analysis. Materials and Methods: To detect empirical studies, we developed search strategies for use in Medline electronic database, using only related keywords, based on MeSH terms: peripheral nerve injuries, peripheral nerve damage, peripheral intravenous therapy, venipuncture, periphera lintravenous cannulation. The studies included in this analysis were published in English. Results: The likelihood of peripheral nerve injury related to venipuncture and peripheral intravenous cannulation is often citedin the research literature. However, there have been more frequent reports of nerve injury consequent on venepuncture in comparison to rare case reports of peripheral nerve injury from intravenous cannulation. Based on Seddon's classification of nerve injuries, a review of the literature shows incidence of all three types of injury. Conclusions: Peripheral intravenous therapy is the most common procedures performed by nurses in their everyday clinical practice, can cause different types of damage to the peripheral nerves.
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Seely, Mason, Jordan D. Deaner, and Lejla Vajzovic. "A Unique Case of Syphilitic Hypopyon Panophthalmitis." Journal of VitreoRetinal Diseases 6, no. 4 (July 2022): 308–11. http://dx.doi.org/10.1177/24741264211066741.
Повний текст джерелаАнотація:
Purpose: This work reports a unique case of syphilitic hypopyon panophthalmitis. Methods: A case report is presented. Results: A 25-year-old man with a history of HIV and intravenous (IV) drug use presented to an outside hospital with blurred vision and swelling of the right eye. Computed tomography was concerning for orbital cellulitis. On examination, he had limited extraocular motility, relative exophthalmos, periocular edema, 4+ anterior chamber cell, an irregular layering hypopyon, and no view of the fundus. Magnetic resonance imaging showed enhancement of the sclera, lateral rectus muscle, and lacrimal gland concerning for infectious or inflammatory panophthalmitis. The patient’s history and presentation were concerning for bacterial or fungal etiologies from an endogenous source. He began antimicrobial therapy. Diagnostic vitrectomy was unrevealing. Syphilis testing was positive. The patient showed improvement with IV antiluetic therapy. Conclusions: We present a case of syphilitic hypopyon panophthalmitis, a new constellation of findings in syphilitic ocular disease.
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Pietersen, Pia I., Björg Kristjansdottir, Christian Laursen, Gitte M Jørgensen, and Ole Graumann. "Systemic air embolism following computed-tomography-guided transthoracic needle biopsy of lung lesion – a systematic search of case reports and case series." Acta Radiologica Open 11, no. 6 (June 2022): 205846012210966. http://dx.doi.org/10.1177/20584601221096680.
Повний текст джерелаАнотація:
Background Systemic air embolism is a rare, however potentially fatal, low incidence, complication to CT-guided transthoracic needle biopsy of lung lesions. Purpose The purpose of this review of case reports and series was to pool data about this rare complication and glance for a pattern or similarities in the patients’ initial symptoms and course, as well as the management of the patients in relation to current guidelines. Material and methods PubMed was searched for case reports and case series about systemic air embolisms following CT-guided transthoracic needle biopsy of lung lesions from inception to November 2021. A reviewer screened the results for eligibility and included studies which reported at least two outcomes of interest. Data was extracted by one author and a descriptive analysis was conducted. Results Of 1,136 studies screened, 83 were eligible for inclusion involving 97 patients. The mean age was 64.8±11.7 years and ≈60% of the patients were men. In 15 cases the outcome was fatal, and most of the fatal cases ( n = 12) had cardiac arrest as the primary initial symptom. In addition to conventional oxygen therapy, 34 patients received hyperbaric oxygen therapy, and in 30 cases the physician in charge chose to change the patient from standard supine position to – most often – Trendelenburg position. Conclusion No similarities were found that could lead to more rapid diagnosis or more correct management. The staff should keep systemic air embolisms in mind, when more common complications are ruled out, and consider hyperbaric oxygen therapy in case of suspicion.
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Tzartzas, Konstantinos, Yves de Roten, and Gilles Ambresin. "Intensive and Brief Psychodynamic Psychotherapy in Severely Depressed Inpatients: A Case Study and Thematic Analysis." Psychodynamic Psychiatry 51, no. 2 (June 2023): 224–40. http://dx.doi.org/10.1521/pdps.2023.51.2.224.
Повний текст джерелаАнотація:
Introduction: Psychotherapy added to usual hospital care is beneficial. This study reports on two contrasting cases, one responder and one nonresponder, from a randomized controlled trial on the effectiveness of intensive and brief psychodynamic psychotherapy (IBPP) for depressed inpatients, in which reduction in depressive severity was maintained for up to 1 year after completion of IBPP. We aimed to explore how the psychotherapist and patient interacted to work through the themes of focalization (described in the IBPP manual) and how their work was part of a potential process of change. Methods: This case study is part of the general framework of mixed methods in psychotherapy combining quantitative analysis of data collected in a randomized controlled trial with a qualitative case study. Results: Two general categories emerged—(1) becoming the subject of one's depression and (2) regaining a sense of support—which combine specific functions. In the first, the functions relate to interactions in line with the psychoanalytic work of mourning, which aims for an appropriation of depressive symptoms. In the second, interactions have as their functions the construction of a therapeutic space and the restoration of an epistemic trust by acknowledging the patient's melancholic state and maintaining emotional contact. Work related to regaining a sense of support was observed in both cases, whereas work related to becoming the subject of one's depression was more specific to the responder case. Discussion: These results highlight the importance of interventions that help generate a sense of support and mobilize the internal processes of symbolization, understanding, and appropriation, leading patients to develop the capacity to give meaning to their symptoms and to understand the personal psychological factors related to the depressive episode.
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Lamoth, Frédéric, Manuel Pascual, Véronique Erard, Jean-Pierre Venetz, Ghaleb Nseir, and Pascal Meylan. "Low-dose Cidofovir for the Treatment of Polyomavirus-Associated Nephropathy: Two Case Reports and Review of the Literature." Antiviral Therapy 13, no. 8 (November 2008): 1001–9. http://dx.doi.org/10.1177/135965350801300806.
Повний текст джерелаАнотація:
Background Polyomavirus-associated nephropathy (PVAN) is a serious complication and cause of graft loss in kidney transplant recipients. In the absence of specific antiviral drugs, early detection of the disease and reduction of immunosuppressive regimen is the cornerstone of therapy. Cidofovir, a nucleoside analogue, has been found to inhibit BK virus (BKV) replication in vitro and has been proposed as treatment of refractory PVAN at low doses; however, its efficacy has never been demonstrated in randomized controlled trials. Methods Cidofovir therapy (0.5 mg/kg at a 2-week interval for eight consecutive doses) was initiated in two patients with biopsy-proven PVAN and persistent BKV DNA viraemia (≥10,000 copies/ml despite sustained reduction of the immunosuppressive regimen). In addition to these two case reports, we performed a critical review of the literature on the use of cidofovir in PVAN. Results No significant decrease of BKV viral load in blood was observed during cidofovir therapy and in follow-up of the two patients treated with cidofovir. Our literature review identified 21 publications reporting the use of cidofovir for the treatment of PVAN. All were case reports or small series. The efficacy of cidofovir therapy could not be assessed in 17 of these publications because of lack of data or concomitant reduction of immunosuppressive regimen. The four remaining publications were case reports. Conclusions In vitro and clinical data to support the efficacy of cidofovir in the treatment of PVAN are currently lacking. More promising compounds should be identified for further clinical studies.
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Văcăraş, Vitalie, George Vithoulkas, Anca Dana Buzoianu, Ioan Mărginean, Zoltan Major, Veronica Văcăraş, Romulus Dan Nicoară, and Menachem Oberbaum. "Homeopathic Treatment for Postpartum Depression: A Case Report." Journal of Evidence-Based Complementary & Alternative Medicine 22, no. 3 (December 22, 2016): 381–84. http://dx.doi.org/10.1177/2156587216682168.
Повний текст джерелаАнотація:
Postpartum psychosis has long-lasting consequences for mother and child. Beside depression, sleep and eating disturbances, exhaustion, social withdrawal, and anxiety, postpartum depression can also interfere with normal maternal-infant bonding and adversely affect child development. Recent reports show that most affected pregnant women are hesitant about taking antidepressant drugs, with a high percentage discontinuing their use. Some authors suggest that the reluctance of pregnant women to take antidepressant drugs should encourage clinicians to discuss with their patients the use of psychological interventions or alternative forms of treatment. In this article, a case of severe postpartum depression, treated successfully with homeopathic therapy, is presented. Considering the high noncompliance of women suffering from postpartum depression with conventional antidepressant medication, research in safe complementary medical methods is justified. One of these methods should be homeopathy.
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Zakhour, Stephanie, Antonio E. Nardi, Michelle Levitan, and Jose Carlos Appolinario. "Cognitive-behavioral therapy for treatment-resistant depression in adults and adolescents: a systematic review." Trends in Psychiatry and Psychotherapy 42, no. 1 (March 2020): 92–101. http://dx.doi.org/10.1590/2237-6089-2019-0033.
Повний текст джерелаАнотація:
Abstract Objective To conduct a systematic review of literature on use and efficacy of cognitive-behavioral therapy (CBT) for treatment of treatment-resistant depression in adults and adolescents. Methods We performed a systematic review according to the Prisma Guidelines of literature indexed on the PubMed, SciELO, Psychiatry Online, Scopus, PsycArticles, Science Direct and the Journal of Medical Case Reports databases. Randomized controlled trials, open studies and case reports were included in the review. Results The searches returned a total of 1,580 articles, published from 1985 to 2017. After applying the inclusion criteria, 17 articles were selected, their complete texts were read and 8 were included in this review. Four of these studies were randomized controlled trials with adults, one of which covered a post-study follow-up period; two were randomized controlled trials with adolescents, one of which presented follow-up data; one was an open study; and one was a case report. The studies provide good quality and robust evidence on the topic addressed. Conclusions A combination of CBT with pharmacotherapy for treatment-resistant patients shows a decrease in depressive symptoms. CBT can be an effective type of therapy for adults and adolescents with treatment-resistant depression.
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Wittayanukorn, Saranrat, Jingjing Qian, Brandon S. Johnson, and Richard A. Hansen. "Cardiotoxicity in targeted therapy for breast cancer: A study of the FDA adverse event reporting system (FAERS)." Journal of Oncology Pharmacy Practice 23, no. 2 (July 9, 2016): 93–102. http://dx.doi.org/10.1177/1078155215621150.
Повний текст джерелаАнотація:
Purpose Cancer chemotherapy-induced cardiotoxicity is concerning. Certain anthracyclines and targeted therapies are known to have potential for cardiotoxicity, but existing trial evidence is inadequate to understand real-world patterns of cardiotoxicity with newer targeted therapies and their common combinations with older agents. This study evaluated chemotherapy-related cardiotoxicity reports for targeted therapies and their combinations in breast cancer patients. Methods The US Food and Drug Administration Adverse Event Reporting System (FAERS) database from January 2004 through September 2012 was used to summarize characteristics of reported cardiotoxicity events and their health outcomes. Disproportionality analyses with reporting odds ratios (ROR) and 95% confidence intervals (95% CI) were conducted to detect event signals using a case/non-case method for each targeted therapy and combination. Results A total of 59,739 cases of cardiotoxicity reports were identified; 937 cases identified targeted therapy as the suspect drug. Trastuzumab had the highest number of reports followed by bevacizumab and lapatinib. Proportions of reports of death and disability outcomes for each targeted therapy were approximately 20–25% of the total reports of serious events. Trastuzumab had the highest ROR as a single agent (ROR = 5.74; 95% CI = 5.29–6.23) or combination use of cyclophosphamide (ROR = 16.83; 95% CI = 13.32–21.26) or doxorubicin (ROR = 17.84; 95% CI = 13.77–23.11). Relatively low cardiotoxicity reporting rates were found with lapatinib, regardless of use with combination therapy. Conclusions Analysis of FAERS data identified signals for adverse cardiotoxicity events with targeted therapies and their combinations. Practitioners should consider factors that may increase the likelihood of cardiotoxicity when assessing treatment. Findings support continued surveillance, risk factor identification, and comparative studies.