Готові списки джерел за темами / PSPC1

Добірка наукової літератури з теми "PSPC1"

Автор: Grafiati
Опубліковано: 6 вересня 2023

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Статті в журналах з теми "PSPC1"

1

Moreno, Adriana T., Maria Leonor S. Oliveira, Paulo L. Ho, Cintia F. M. Vadesilho, Giovana M. P. Palma, Jorge M. C. Ferreira, Daniela M. Ferreira, Silvia R. Santos, Marina B. Martinez, and Eliane N. Miyaji. "Cross-Reactivity of Antipneumococcal Surface Protein C (PspC) Antibodies with Different Strains and Evaluation of Inhibition of Human Complement Factor H and Secretory IgA Binding via PspC." Clinical and Vaccine Immunology 19, no. 4 (February 15, 2012): 499–507. http://dx.doi.org/10.1128/cvi.05706-11.

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Анотація:
ABSTRACTPneumococcal surface protein C (PspC) is an important candidate for a cost-effective vaccine with broad coverage against pneumococcal diseases. Previous studies have shown thatStreptococcus pneumoniaeis able to bind to both human factor H (FH), an inhibitor of complement alternative pathway, and human secretory IgA (sIgA) via PspC. PspC was classified into 11 groups based on variations of the gene. In this work, we used three PspC fragments from different groups (PspC3, PspC5, and PspC8) to immunize mice for the production of antibodies. Immunization with PspC3 induced antibodies that recognized the majority of the clinical isolates as analyzed by Western blotting of whole-cell extracts and flow cytometry of intact bacteria, while anti-PspC5 antibodies showed cross-reactivity with the paralogue pneumococcal surface protein A (PspA), and anti-PspC8 antibodies reacted only with the PspC8-expressing strain. Most of the isolates tested showed strong binding to FH and weaker interaction with sIgA. Preincubation with anti-PspC3 and anti-PspC5 IgG led to some inhibition of binding of FH, and preincubation with anti-PspC3 partially inhibited sIgA binding in Western blotting. The analysis of intact bacteria through flow cytometry showed only a small decrease in FH binding after incubation of strain D39 with anti-PspC3 IgG, and one clinical isolate showed inhibition of sIgA binding by anti-PspC3 IgG. We conclude that although anti-PspC3 antibodies were able to recognize PspC variants from the majority of the strains tested, partial inhibition of FH and sIgA binding through anti-PspC3 antibodiesin vitrocould be observed for only a restricted number of isolates.
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2

Jen, Hsin-Wei, De-Leung Gu, Yaw-Dong Lang, and Yuh-Shan Jou. "PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility." Cells 9, no. 6 (June 18, 2020): 1490. http://dx.doi.org/10.3390/cells9061490.

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Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients. However, the detail molecular mechanisms to facilitate cancer cell migration remain elusive. Here, we conducted integrated analysis of human phospho-kinase antibody array, transcriptome analysis with RNA-seq, and proteomic analysis of protein pulldown to study the molecular detail of PSPC1-potentiated phenotypical transformation, adhesion, and motility in human hepatocellular carcinoma (HCC) cells. We found that PSPC1 overexpression re-assembles and augments stress fiber formations to promote recruitment of focal adhesion contacts at the protruding edge to facilitate cell migration. PSPC1 activated focal adhesion-associated kinases especially FAK/Src signaling to enhance cell adhesion and motility toward extracellular matrix (ECM). Integrated transcriptome and gene set enrichment analysis indicated that PSPC1 modulated receptor tyrosine kinase IGF1R involved in the focal adhesion pathway and induction of diverse integrins expression. Knockdown IGF1R expression and treatment of IGF1R inhibitor suppressed PSPC1-induced cell motility. Interestingly, knockdown PSPC1-interacted paraspeckle components including NONO, FUS, and the lncRNA Neat1 abolished PSPC1-activated IGF1R expression. Together, PSPC1 overexpression induced focal adhesion formation and facilitated cell motility via activation of IGF1R signaling. PSPC1 overexpression in tumors could be a potential biomarker of target therapy with IGF1R inhibitor for improvement of HCC therapy.
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3

Major, Andrew T., Cathryn A. Hogarth, Yoichi Miyamoto, Mai A. Sarraj, Catherine L. Smith, Peter Koopman, Yasuyuki Kurihara, David A. Jans та Kate L. Loveland. "Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles". Molecular Biology of the Cell 26, № 8 (15 квітня 2015): 1543–58. http://dx.doi.org/10.1091/mbc.e14-01-0678.

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Анотація:
Importin (IMP) superfamily members mediate regulated nucleocytoplasmic transport, which is central to key cellular processes. Although individual IMPα proteins exhibit dynamic synthesis and subcellular localization during cellular differentiation, including during spermatogenesis, little is known of how this affects cell fate. To investigate how IMPαs control cellular development, we conducted a yeast two-hybrid screen for IMPα2 cargoes in embryonic day 12.5 mouse testis, a site of peak IMPα2 expression coincident with germ-line masculization. We identified paraspeckle protein 1 (PSPC1), the original defining component of nuclear paraspeckles, as an IMPα2-binding partner. PSPC1-IMPα2 binding in testis was confirmed in immunoprecipitations and pull downs, and an enzyme-linked immunosorbent assay–based assay demonstrated direct, high-affinity PSPC1 binding to either IMPα2/IMPβ1 or IMPα6/IMPβ1. Coexpression of full-length PSPC1 and IMPα2 in HeLa cells yielded increased PSPC1 localization in nuclear paraspeckles. High-throughput image analysis of >3500 cells indicated IMPα2 levels can directly determine PSPC1-positive nuclear speckle numbers and size; a transport-deficient IMPα2 isoform or small interfering RNA knockdown of IMPα2 each reduced endogenous PSPC1 accumulation in speckles. This first validation of an IMPα2 nuclear import cargo in fetal testis provides novel evidence that PSPC1 delivery to paraspeckles, and consequently paraspeckle function, may be controlled by modulated synthesis of specific IMPs.
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4

Díaz-García, Elena, Sara García-Tovar, Raquel Casitas, Ana Jaureguizar, Ester Zamarrón, Begoña Sánchez-Sánchez, Ana Sastre-Perona, Eduardo López-Collazo, Francisco Garcia-Rio, and Carolina Cubillos-Zapata. "Intermittent Hypoxia Mediates Paraspeckle Protein-1 Upregulation in Sleep Apnea." Cancers 13, no. 15 (August 2, 2021): 3888. http://dx.doi.org/10.3390/cancers13153888.

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Анотація:
As some evidence suggests that hypoxia might be an inducer of nuclear paraspeckle formation, we explore whether intermittent hypoxia (IH)-mediated paraspeckle protein-1 (PSPC1) overexpression might contribute to the activation of tumor growth factor (TGF)β-SMAD pathway in patients with obstructive sleep apnea (OSA). This activation would promote changes in intracellular signaling that would explain the increased cancer aggressiveness reported in these patients. Here, we show that patients with OSA exhibit elevated PSPC1 levels both in plasma and in monocytes. Our data suggest that PSPC1 is ultimately delivered to the plasma through its cleavage from OSA monocytes by matrix metalloproteinase-2 (MMP2). In addition, IH promotes PSPC1, TGFβ, and MMP2 expression in monocytes through the hypoxia-inducible factor. Lastly, both PSPC1 and TGFβ induce increased expression of genes that drive the epithelial-to-mesenchymal transition. Our study details the mechanism by which hypoxemia upmodulates the extracellular release of PSPC1 by means of MMP2, such that plasma PSPC1 together with TGFβ activation signaling further promotes tumor metastasis and supports cancer aggressiveness in patients with OSA.
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5

Li, Shuyi, Zhentian Li, Feng-Jue Shu, Hairong Xiong, Andrew C. Phillips, and William S. Dynan. "Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog." Nucleic Acids Research 42, no. 15 (August 6, 2014): 9771–80. http://dx.doi.org/10.1093/nar/gku650.

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Анотація:
Abstract NONO, SFPQ and PSPC1 make up a family of proteins with diverse roles in transcription, RNA processing and DNA double-strand break (DSB) repair. To understand long-term effects of loss of NONO, we characterized murine embryonic fibroblasts (MEFs) from knockout mice. In the absence of genotoxic stress, wild-type and mutant MEFs showed similar growth rates and cell cycle distributions, and the mutants were only mildly radiosensitive. Further investigation showed that NONO deficiency led to upregulation of PSPC1, which replaced NONO in a stable complex with SFPQ. Knockdown of PSPC1 in a NONO-deficient background led to severe radiosensitivity and delayed resolution of DSB repair foci. The DNA-dependent protein kinase (DNA-PK) inhibitor, NU7741, sensitized wild-type and singly deficient MEFs, but had no additional effect on doubly deficient cells, suggesting that NONO/PSPC1 and DNA-PK function in the same pathway. We tested whether NONO and PSPC1 might also affect repair indirectly by influencing mRNA levels for other DSB repair genes. Of 12 genes tested, none were downregulated, and several were upregulated. Thus, NONO or related proteins are critical for DSB repair, NONO and PSPC1 are functional homologs with partially interchangeable functions and a compensatory response involving PSPC1 blunts the effect of NONO deficiency.
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6

Major, Andrew T., Cathryn A. Hogarth, Julia C. Young, Yasuyuki Kurihara, David A. Jans, and Kate L. Loveland. "Dynamic paraspeckle component localisation during spermatogenesis." Reproduction 158, no. 3 (September 2019): 267–80. http://dx.doi.org/10.1530/rep-19-0139.

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Анотація:
Expression profiles and subcellular localisations of core Drosophila behaviour/human splicing (DBHS) proteins (PSPC1, SFPQ and NONO) and NEAT1, a long noncoding RNA (lncRNA), are investigated in developing and adult mouse testes. Core DBHS proteins are markers for the distinct subnuclear domain termed paraspeckles, while a long NEAT1 isoform scaffold facilitates paraspeckle nucleation. Paraspeckles contain many proteins (>40) and are broadly involved in RNA metabolism, including transcriptional regulation by protein sequestration, nuclear retention of A-to-I edited RNA transcripts to regulate translation and promoting survival during cellular stress. Immunohistochemistry reveals cell-specific profiles for core DBHS paraspeckle protein expression, indicating their functional diversity. PSPC1 is an androgen receptor co-activator, and it is detected in differentiating Sertoli cell nuclei from day 15 onwards, as they develop androgen responsiveness. PSPC1 is nuclear in the most mature male germ cell type present at each age, from foetal to adult life. In adult mouse testes, PSPC1 and SFPQ are present in Sertoli cells, spermatocytes and round spermatids, while the NEAT1 lncRNA appears in the punctate nuclear foci delineating paraspeckles only within Leydig cells. Identification of NEAT1 in the cytoplasm of spermatogonia and spermatocytes must reflect non-paraspeckle-related functions. NONO was absent from germ cells but nuclear in Sertoli cells. Reciprocal nuclear profiles of PSPC1 and γ-H2AX in spermatogenic cells suggest that each performs developmentally regulated roles in stress responses. These findings demonstrate paraspeckles and paraspeckle-related proteins contribute to diverse functions during testis development and spermatogenesis.
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Yeh, Hsi-Wen, та Yuh-Shan Jou. "PSPC1 potentiates TGF-β-dependent metastatic dissemination". Molecular & Cellular Oncology 5, № 4 (4 липня 2018): e1472058. http://dx.doi.org/10.1080/23723556.2018.1472058.

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8

Lang, Yaw-Dong, and Yuh-Shan Jou. "PSPC1: a contextual determinant of tumor progression." Molecular & Cellular Oncology 7, no. 2 (February 3, 2020): 1721253. http://dx.doi.org/10.1080/23723556.2020.1721253.

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9

Passon, Daniel M., Mihwa Lee, Archa H. Fox, and Charles S. Bond. "Crystallization of a paraspeckle protein PSPC1–NONO heterodimer." Acta Crystallographica Section F Structural Biology and Crystallization Communications 67, no. 10 (September 29, 2011): 1231–34. http://dx.doi.org/10.1107/s1744309111026212.

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10

Knott, Gavin J., Yee Seng Chong, Daniel M. Passon, Xue-hai Liang, Evelyne Deplazes, Maria R. Conte, Andrew C. Marshall, Mihwa Lee, Archa H. Fox, and Charles S. Bond. "Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1." Nucleic Acids Research 50, no. 1 (December 14, 2021): 522–35. http://dx.doi.org/10.1093/nar/gkab1216.

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Анотація:
Abstract The Drosophila behaviour/human splicing (DBHS) proteins are a family of RNA/DNA binding cofactors liable for a range of cellular processes. DBHS proteins include the non-POU domain-containing octamer-binding protein (NONO) and paraspeckle protein component 1 (PSPC1), proteins capable of forming combinatorial dimers. Here, we describe the crystal structures of the human NONO and PSPC1 homodimers, representing uncharacterized DBHS dimerization states. The structures reveal a set of conserved contacts and structural plasticity within the dimerization interface that provide a rationale for dimer selectivity between DBHS paralogues. In addition, solution X-ray scattering and accompanying biochemical experiments describe a mechanism of cooperative RNA recognition by the NONO homodimer. Nucleic acid binding is reliant on RRM1, and appears to be affected by the orientation of RRM1, influenced by a newly identified ‘β-clasp’ structure. Our structures shed light on the molecular determinants for DBHS homo- and heterodimerization and provide a basis for understanding how DBHS proteins cooperatively recognize a broad spectrum of RNA targets.
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Більше джерел

Дисертації з теми "PSPC1"

1

Cvirkienė, Dovilė. "Pacientų požiūris į medicininių paslaugų saugą PSPC grandyje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140930_085641-10166.

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Анотація:
Darbo tikslas – įvertinti pacientų nuomonę ir požiūrį apie atliekamų paslaugų saugą PSP grandyje. Uždaviniai: Išanalizuoti pacientų nuomonę apie atliekamų medicininių paslaugų saugą PSP įstaigoje. Įvertinti paciento požiūrį apie gydymo vaistais saugumą. Išanalizuoti, paciento ir gydytojo tarpusavio pasitikėjimo aspektus, siekiant efektyvaus ir saugaus gydymo. Ištirti pacientų požiūrį į nepageidaujamų įvykių priežastis ir jų registravimo sistemą. Tyrimo metodika. Kiekybinis momentinis tyrimas. Tyrimo laikas: 2013 m. sausio - balandžio mėn. Tyrimo vieta - UAB „Šilainių šeimos sveikatos centras“. Tiriamoji imtis 378 respondentai. Atsako dažnis - 94,5 proc. Rezultatai. Respondentams svarbus sveikatos priežiūros paslaugų prieinamumas ir jų savalaikiškumas (22,49 proc. ir 20,37 proc., atitinkamai). 63,49 proc. pacientų žino, kas yra pacientų sauga, todėl vertina komunikavimą su gydytoju, teiraujasi apie paskirtus vaistus, jų pašalines reakcijas, domisi paskirtu gydymu. 38,89 proc. respondentų nuomonė apie antibiotikų skyrimo pagrįstumą yra teigiama, o juos vartoja pagal gydytojo rekomendacijas. Bendravimo tarp personalo ir paciento analizė, parodė, kad visais analizuotais atvejais tarpusavio bendravimas tarp personalo ir paciento yra vertinamas pakankamai gerai. Jaunesni respondentai žymiai dažniau nei vyresni linkę reikšti savo nuomonę, dažniau teiraujasi apie savo sveikatą, dalyvauja jiems svarbių sprendimų priėmime. Respondentai mano, kad dažniausia... [toliau žr. visą tekstą]
Objective of the work – to assess the patients’ opinion and attitude to the safety in the primary health care. Tasks: To analyze the patients’ opinion about the safety of medical services provided in the primary health care facilities. To evaluate the patient’s attitude to the safety of conservative treatment. To analyze the aspects of mutual trust of doctor and patient in order to achieve effective and safe treatment. To examine the patients’ attitude to the reasons of undesirable events and their registration system. Research methodology. Quantitative survey. Study time: January-April 2013. Place of research – Silainiai Family Health Center Ltd. Analyzed sample – 378 respondents. Response frequency – 94,5 percent. Results. The respondents find the accessability and timeliness of the health care services important (22,49 percent and 20,37 percent accordingly). 63,49 percent of the patients are familiar with the safety of patients, thus they appreciate communication with the doctor, inquire about the prescribed medicine, their side effects, and show interest in the prescribed treatment. 38,89 –percent of respondents think that prescription of antibiotics is reasonable and they use antibiotics according to the recommendations of the doctor. The analysis of the communication of the patient and the doctor revealed that in all the analyzed cases the interrelations between the staff and the patient are evaluated quite well. The younger respondents tend to... [to full text]
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2

Vadesilho, Cintia Fiuza Marques. "Mapeamento de epitopos presentes em variantes dos antígenos vacinais PspA (Pneumococcal surface protein A) e PspC (Pneumococcal surface protein C) de Streptococcus pneumoniae." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06122014-075950/.

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Анотація:
S. pneumoniae pode causar infecções do trato respiratório. Uma alternativa às vacinas conjugadas, que conferem proteção sorotipo-específica, seria uma vacina baseada em epitopos de diferentes variantes de antígenos como PspA e PspC. O objetivo deste trabalho foi a identificação de epitopos de variantes de PspA e PspC, utilizando a técnica peptide array, visando a síntese de um antígeno composto por múltiplos epitopos. Os resultados obtidos indicaram que anticorpos contra epitopos lineares de PspA reconhecem as regiões inicial N-terminal e rica em prolinas, mas estes epitopos parecem ser apenas marcadores de exposição ao pneumococo e epitopos conformacionais seriam os de fato protetores, como observado nos experimentos realizados com os Frags de 100 aminoácidos construídos a partir do PspARx1, especialmente aqueles presentes nas regiões dos Frags 2 e 4. Epitopos lineares de PspC parecem ser importantes na região de ligação à sIgA e FH. Assim, uma vacina proteica de ampla cobertura, poderia conter as regiões do Frag 2 de PspA e de ligação de sIgA e FH de PspC.
S. pneumoniae can cause respiratory tract infections. An alternative to the conjugate vaccines, which confer serotype-specific protection, would be a vaccine based on epitopes of variants of antigens such as PspA and PspC. The objective of this study was to identify epitopes of variants of PspA and PspC, using the peptide array technique, aiming at the synthesis of a multi-epitope antigen. The results obtained with peptide arrays indicated that antibodies against linear epitopes of PspA recognize the initial N-terminal and proline-rich regions, but these epitopes seem to be only markers of exposure to pneumococcus and conformational epitopes would be in fact protective, as observed in the experiments with fragments of 100 amino acids constructed from PspARx1, especially those present in Frags 2 and 4. Linear epitopes of PspC seem to be important in the regions of sIgA and FH binding. Thus, a protein-based vaccine with broad coverage could contain the regions of Frag 2 of PspA and the regions of sIgA and FH binding of PspC.
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3

Elkharaz, Jamal Ibrahim. "Proteomics of mouse cortex following conditional deletion of Psmc1 proteasomal subunit in neurones." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13712/.

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Анотація:
Neurodegenerative diseases are characterized by progressive degeneration of selective neurones in the nervous system and the formation of protein inclusions in surviving neurones. The mechanisms underlying neurodegeneration and neuroprotection in the nervous system remain elusive. Ubiquitin is one of the hallmarks of neuropathological inclusions in the majority of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Therefore, dysfunction of the ubiquitin proteasome system has been implicated in disease cause and/or progression. This thesis investigates a unique conditional genetic mouse model of neurodegeneration caused by conditional genetic 26S proteasomal depletion in mouse forebrain neurones. We have identified potential proteins targeted for ubiquitination in brain using bio-affinity chromatography of zinc finger protein ZNF216 coupled with mass spectrometry. This lead to the identification of several potential ubiquitinated proteins involved in gene expression and regulation. We have also investigated the global brain proteome in response to 26S proteasomal depletion in neurones using two-dimensional fluorescence difference in-gel electrophoresis coupled to mass spectrometry for protein identification. Several differentially expressed proteins were identified in the 26S proteasome-depleted cortex. Astrocytic intermediate filament proteins glial acid fibrillary protein and vimentin, as well as the antioxidant peroxiredxoin-6, were upregulated. Mitochondrial fumarate hydratase and stathmin-1, involved in the tricarboxylic acid cycle and cytoskeletal microtubule dynamics respectively, were downregulated. These proteins have been validated by biochemical and immunohistochemical approaches. Further analysis of oxidative stress revealed increased lipid and protein oxidation that may be involved in the neurodegeneration associated with 26S proteasomal depletion. However, we also show increased phospholipase A2 activity associated with peroxiredoxin-6 expression that may have additional roles in neurodegenerative and/or neuroprotective functions. Interestingly, the levels of reactive oxygen species were inversely correlated with the upregulation of peroxiredoxin-6. We suggest that peroxiredoxin-6 may play an important role in the brain in the protection against oxidative stress and our studies may improve our physiological and pathological understanding of neurodegenerative disease.
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4

Smith, Anthony. "An investigation of the region of DNA required for Streptocymes Penemafaciens plasmid pSPN1 replication." Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/22128.

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Анотація:
Plasmid pSPNl is a 26.5kb cryptic plasmid, originally isolated from Streptomyces penemafaciens ATCC 31599. A 12.5kb BglII fragment of pSPNl was cloned into the vector pLR2, and this conferred on pLR2 which lacks a Streptomyces origin of replication, the ability to replicate in a number of Streptomyces species. A vector pBlue was constructed by inserting a streptomycin resistance gene from plasmid pIJ4642 into the ampicillin resistance gene of the vector Bluescript. The resistance gene was able to function in both E.coli and Streptomyces species and thus pBlue could serve as a vector for shortening and sequencing in E. coli as well as a origin-probe vector in Streptomyces. The origin-containing BglII fragment of pSPNl was cloned into pBlue to create pFull, which was able to be selected for and replicate in Streptomyces. The conditions affecting selection of pFull in Streptomyces were investigated and optimized. The copy number of pFull was found to be 0.2 per chromosome. Attempts were made to clone origin-containing fragments smaller than the 12.5kb BglII fragment. Initially a Sau3A partial library was made of the origin-containing fragment, this however did not produce any replicating plasmids. As an alternative approach, pFull was extensively mapped and a series of deletion derivatives were constructed. The derivatives were tested for the ability to replicate in Streptomyces. Judging from the deletions that were and were not able to replicate it is apparent that at least 5.5kb of DNA is required for pFull and hence for pSPNl to replicate.
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5

Lindström, Nils. "Prokaryotic expression of human complement regulator factor H domains and their interaction withPneumococcal surface protein PspC." Thesis, KTH, Skolan för bioteknologi (BIO), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215297.

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Анотація:
One of the oldest and most exciting questions in science is: are we alone in the universe? During the last four billion years of Earth’s history, countless organisms have inhabited almost every environmental niche on the planet, from the deepest sea to driest deserts. However, so far no extraterrestrial life has been found. Studying the propensity for life on our neighboring planet, Mars,helps us understanding its potential for past and present life, and guides future missions. Liquid water is a prerequisite for life as we know it and recently, evidence of transient night time liquidbrines on the surface of present day Mars have been theorized. These brines may be hyper-salinewith high ionic strengths and varying pH-values. Halobacterium salinarum is an extremophilic (saltloving) halophilic archaeon whose natural habitat includes hyper-saline brines, desiccating conditions and exposure to high fluences of solar UV radiation. Herein, we report the response of Hbt.salinarum following exposure to simulated Martian conditions, with regard to survival and DNAintegrity. The simulated conditions include the synthetic Martian Brine Analogues (MBAs), diurnalnocturnaltemperature cycling, prolonged desiccation and Mars-like solar UV (200-400 nm) radiation.We also addressed the prolific space hardware contaminant, Bacillus subtilis whose endospores show substantial resistance against space conditions. The ambition was to investigate potentia linterplanetary forward contamination by Hbt. salinarum, should it have bacterial spores available as nutrients in the Martian brines. Halophiles are some of our best candidates for studying unicellular life on Mars and other bodies where liquid water is also stabilized by high salt concentrations.Moreover, Hbt. salinarum was able to survive over one month in the Martian brines, albeit with growth limited to one particularly hospitable brine. It displayed survival in the brines at relevant temperatures and with diurnal-nocturnal cycling but only when first desiccated to remove preventwater crystal formation. The radiation resistance was highly dependent on the choice of brine inwhich Hbt. salinarum was confined and desiccated. Even in the hospitable brines, the halophile lost over 90% of its viable population following irradiation equal to one Martian day, in our experimentalsetup. The inter-brine difference in DNA fragmentation following irradiation confirmed the differencein survival. Hbt. salinarum was subsequently unable to digest B. subtilis endospores for nutrient exploit and responded no differently than when nutrient-deprived. Surprisingly, the addition of otherwise available nutrients in the brines caused a hurried decrease in survival, with the exception of the hospitable brine. Despite its extremophilic and polyextremotolerant character, Hbt. salinarumis unlikely to survive, not to mention thrive, in a combination of all tested stressors.
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6

Makou, Elisavet. "Architecture of the central region of factor H and its interaction with PspC of S. pneumoniae." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/11822.

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The complement system is a major component of innate immunity and an effector of antibody-mediated immune responses. Unlike the other two activation pathways of the complement system, the alternative pathway is permanently switched on. Discrimination by complement between self and foreign is therefore achieved by selective protection of healthy host tissue and cells. This study investigated the alternative pathway regulator factor H (FH), which is crucial for protection of self surfaces from complement. FH engages via its N- and C- terminal ends with activation-specific fragments of C3, C3b and C3d. The middle region of FH has no binding sites for complement components. It presumably ensures that the binding sites at either end of the extended and flexible FH molecule cooperate in recognizing C3b in fluid phase or on self surfaces, but not on foreign targets. This study was aimed at achieving an atomic level understanding of the structure of the middle portion of FH, thereby testing hypotheses as to how it promotes the overall biological efficacy of the intact protein. High-resolution NMR-derived structures of two module pairs FH-10-11 and FH-11-12 were solved and combined with SAXS data to produce a model of FH-10-12. This was combined, in silico, with the previously solved FH-12-13 structure, then the model of FH-10-13 was used to revisit SAXS data for FH-10-15 and FH-8-15. A unique structure emerged, unlike any other encountered previously in the family of complement regulators, in which CCPs 13, 14 and 15 have a highly compacted organization that has repercussions for function. While devoid of binding affinity for host ligands, this central region is a binding site for PspC, a virulence factor of S. pneumoniae. It has been speculated that the bacteria use this interaction to sequester FH in a conformation that resembles the one adopted by FH on self cells and makes it particularly good at regulating complement. Structural and functional investigations of this interaction were performed to establish the molecular basis of the use of FH by this pathogen in order to avoid complement-mediated elimination. It was found that PspC and FH form a near-irreversible complex, while FH-8-15 binds PspC almost as tightly as intact protein. When bound to PspC, FH has a higher affinity for some of its targets, supporting the theory that this bacterial protein stabiles a particularly active conformation of the regulator.
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Agarwal, Vaibhav. "Role of PspC interaction with human polymeric immunoglobulin receptor and Factor H in Streptococcus pneumoniae infections and host cell induced signalling." kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/3652/.

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Moreno, Adriana Tonet. "Avaliação da variabilidade do candidato vacinal PspC (Pneumococcal surface protein C) em isolados de Streptococcus pneumoniae do Hospital Universitário da Universidade de São Paulo." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06112013-102932/.

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Streptococcus pneumoniae é o agente causador de diversas doenças, tais como meningite e pneumonia. PspC (Pneumococcal surface protein C) foi descrito como um importante candidato vacinal proteico de ampla cobertura e com baixo custo de produção. Trata-se de um fator de virulência, capaz de ligar-se ao Fator H (FH) e a IgA secretório (sIgA). Como PspC é um antígeno polimórfico, é crucial a avaliação da sua variabilidade. Foi determinado o grupo de PspC de treze linhagens de pneumococo isoladas no Hospital Universitário da Universidade de São Paulo. Soros contra diferentes grupos de PspC foram produzidos e PspC do grupo 3 (PspC3) foi capaz de induzir anticorpos que reconhecem diferentes grupos de PspC. Foi observada ainda uma pequena redução na ligação de FH e sIgA por anticorpos anti-PspC3 em ensaios in vitro. No entanto, não foi possível observar proteção contra um modelo de colonização da nasofaringe de camundongos através da imunização com PspC3, possivelmente por deficiências no modelo experimental.
Streptococcus pneumoniae is the causative agent of several diseases, such as meningitis and pneumonia. PspC (Pneumococcal surface protein C) has been described as an important vaccine candidate protein as it could provide wide coverage with low cost of production. PspC is a virulence factor capable of binding to Factor H (FH) and secretory IgA (sIgA). PspC is polymorphic antigen, and therefore it is crucial to evaluate its variability. In the present work we have determined the PspC group of 13 pneumococcal isolates obtained at the University Hospital of the University of São Paulo. Antisera against different PspC groups were produced and PspC group 3 (PspC3) was able to induce antibodies that recognized different groups of PspC. Antibodies to PspC3 reduced binding of FH and sIgA to pneumococcus in in vitro assays. However, no protection was observed against a murine model of nasopharyngeal colonization by immunization with PspC3. This was possibly due to deficiencies in the experimental model.
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Tripathi, Sachin Kumar. "Understanding the role of paraspeckle components NEAT1 and PSPC1 in HCV life cycle and pathogenesis." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5960.

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Hepatitis C virus (HCV) is an enveloped, small, icosahedral, positive-sense single-stranded RNA virus that belongs to the Hepacivirus genus and the Flaviviridae family. HCV causes acute and chronic hepatitis which can range in severity from a moderate condition to a serious life-long condition involving liver cirrhosis and cancer. Around 1.5 million new cases of the hepatitis C virus are reported each year, with an estimated 58 million people worldwide carrying the infection. According to the WHO report, 2,90,000 people died of hepatitis C infection in 2019, primarily due to cirrhosis and hepatocellular carcinoma (HCC). HCV infection causes dysregulation of various host factors and signaling pathways, which might result in HCC. Several cellular entities, including paraspeckle components, are involved in the viral life cycle, pathogenesis, and disease progression. Paraspeckles are subnuclear bodies, composed of proteins like Paraspeckle Component 1 (PSPC1), Splicing Factor Proline and Glutamine Rich (PSF), and Non-POU Domain Containing Octamer Binding (NONO), etc. that bind to lncRNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) and form a paraspeckle. They trap various proteins and mRNAs, hindering their function and thereby affecting the cell’s continued response to stress. To understand the molecular basis of HCC, we have studied some of the key components of paraspeckle, the lncRNA NEAT1 and PSPC1 protein in HCV life cycle and pathogenesis. The specific aims of this study are: 1a. Understanding the role of NEAT1 in HCV-induced Hepatocellular Carcinoma 1b. Elucidation of the role of NEAT1 on the HCV life cycle 2. Possible role of paraspeckle protein PSPC1 in the HCV life cycle Part 1a: Understanding the role of NEAT1 in HCV-induced Hepatocellular Carcinoma NEAT1 lncRNA is a major component of paraspeckles that has been linked to several malignancies. Analysis of ‘The Cancer Genome Atlas (TCGA)’ database and validation in HCV-induced HCC tissue and serum samples showed significant high expression of NEAT1 in patients with liver cancer. Moreover, it was observed that NEAT1 levels increased with HCV infection, along with the size and number of the paraspeckles. To further understand the mechanism of NEAT1-induced HCC progression, we selected one of its targets, miR-9-5p, which regulates Beta Ig-H3 (BGH3) mRNA levels. Interestingly, miR-9-5p levels were found to be downregulated upon HCV infection, whereas BGH3 levels were upregulated showing a reverse correlation. Partial knockdown of NEAT1 increased miR-9-5p levels and decreased BGH3 levels, corroborating our initial findings. BGH3 levels were also found to be upregulated in HCV-induced HCC which is consistent with TCGA data and could be directly correlated with NEAT1 levels. As a known oncogene, BGH3 is directly linked to HCC progression mediated by NEAT1. Direct-acting antiviral (DAA)-based treatment is likely to minimize the progression of liver disease and liver-related mortality linked to HCV infection. However, in cirrhotic patients, the risk of HCC persists even after HCV treatment. Elevated levels of NEAT1 were found in serum samples of patients even after treatment with direct-acting antivirals (DAA), indicating that NEAT1 might be a molecular trigger that promotes pathogenesis. Collectively, these findings provide molecular insights into HCV-induced HCC progression via the NEAT1-miR-9-BGH3 axis. Part 1b: Elucidation of the role of NEAT1 on the HCV life cycle The expression of NEAT1 gets elevated in response to viral infection as a stress-induced lncRNA upregulation strategy. However, there are no reports on how NEAT1 or paraspeckles are involved in HCV infection. Interestingly, siRNA-mediated partial silencing of NEAT1 in Huh 7.5 cells increased both positive and negative-strand viral RNA, suggesting that NEAT1 negatively affects the HCV life cycle. NEAT1 resides in the paraspeckles, where it is associated with the proteins, PSF, NONO, and PSPC1. Several reports have indicated that in normal cells, PSF protein is bound to the promoter of several immune-responsive genes and represses their transcription. Upon viral infection, increased NEAT1 level sequesters PSF from the promoter of immune-related genes, thereby increasing their expression. PSF can bind to the DDX60 promoter and inhibit its transcription. We observed that DDX60 level decreases upon silencing of NEAT1 in the background of HCV infection. It appears, upon HCV infection, NEAT1 sequesters PSF from the DDX60 promoter, and hence DDX60 transcription increases. DDX60 is known to inhibit HCV RNA replication, which is regulated by NEAT1, and PSF. Results suggest that NEAT1 regulates HCV RNA by regulating DDX60 levels. Part 2: Possible role of paraspeckle protein PSPC1 in the HCV life cycle Paraspeckle protein PSPC1 (Paraspeckle Component 1) binds to poly(A), poly(G), and poly(U) RNA homopolymers, transports lipid-related genes from nucleus to cytoplasm and increases cell proliferation. PSPC1 is also known for regulating the life cycle of different viruses, but no reports are available on its role during HCV infection. We investigated the role of PSPC1 in HCV life cycle. Earlier, from our lab, we reported several RNA binding proteins of the host, such as HuR, La, and PTB, which relocalizes from the nucleus to the cytoplasm, bind to HCV RNA, and affect its life cycle. Similarly, PSPC1 protein was also found to be relocalized to cytoplasm upon HCV infection. Partial silencing of PSPC1 increased HCV RNA levels, suggesting negative regulation by PSPC1. Immuno-pulldown using anti-PSPC1 antibody followed by RT-qPCR suggested the binding of PSPC1 protein to HCV RNA. Bioinformatics analysis and UV-crosslinking experiments validated the binding of PSPC1 in the HCV 5’ UTR in the SLIV region. Competition UV-crosslinking experiment using cytoplasmic extract (S10) of Huh7.5 cells suggested that PSPC1 can replace host factors from the HCV 5’ UTR. We further observed that PSPC1 protein levels gradually decreased upon HCV infection. It appears, that as a host response, PSPC1 reduces HCV RNA level, and to prevent that as a viral response, HCV decreases PSPC1 protein level. Taken together, in this study the NEAT1/miR-9-5p/BGH3 axis has been linked to the disease progression. Results put forward the idea of using the NEAT1 level as a potential biological marker for disease prognosis to help better strategize the follow-up treatment approaches. Also, the study unravels the dual control of the HCV life cycle by the Paraspeckle components, NEAT1, and PSPC1, which in turn contributes to viral pathogenesis.
CSIR for Fellowship
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YU, MU-KUN, and 余木坤. "A Study on Application of PSPC to The Coating Quality Management for Ships." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/4n6a7w.

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Книги з теми "PSPC1"

1

Turner, T. J. PSPC soft x-ray observations of Seyfert 2 galaxies. Greenbelt, MD: High Energy Astrophysics Science Archive Research Center, NASA Goddard Space Flight Center, 1993.

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2

Turner, T. J. PSPC soft x-ray observations of Seyfert 2 galaxies. Greenbelt, MD: High Energy Astrophysics Science Archive Research Center, NASA Goddard Space Flight Center, 1993.

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3

Turner, T. J. PSPC soft X-ray observations of Seyfert 2 galaxies. Greenbelt, MD: High Energy Astrophysics Science Archive Research Center, NASA Goddard Space Flight Center, 1993.

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4

Turner, T. J. PSPC soft x-ray observations of Seyfert 2 galaxies. Greenbelt, MD: High Energy Astrophysics Science Archive Research Center, NASA Goddard Space Flight Center, 1993.

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5

United States. National Aeronautics and Space Administration., ed. A deep PSPC observation of the Cyg OB2 association: Final report. [Washington, D.C: National Aeronautics and Space Administration, 1995.

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United States. National Aeronautics and Space Administration., ed. A deep PSPC observation of the Cyg OB2 association: Final report. [Washington, DC: National Aeronautics and Space Administration, 1995.

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7

United States. National Aeronautics and Space Administration., ed. A deep PSPC observation of the Cyg OB2 association: Final report. [Washington, DC: National Aeronautics and Space Administration, 1995.

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8

United States. National Aeronautics and Space Administration., ed. A deep PSPC observation of the Cyg OB2 association: Final report. [Washington, D.C: National Aeronautics and Space Administration, 1995.

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9

Gondhalekar, P. M. ROSAT/PSPC Observations and the ionizing continuum of Seyfert 1 galaxy Mkn478. Didcot, Oxon: SERC, 1994.

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Observatory, Smithsonian Astrophysical, and United States. National Aeronautics and Space Administration., eds. ROSAT PSPC observations of CL0016+16: NASA grant NAG5-2156, annual report no. 4 for the period 15 December 1995 through 14 December 1996. Cambridge, Mass: Smithsonian Institution, Astrophysical Observatory, 1996.

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Частини книг з теми "PSPC1"

1

Sidhu, Sukhjot Singh, and Arvind Dhingra. "Day-Ahead Load Forecasting in PSPCL." In Lecture Notes in Civil Engineering, 467–76. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-9554-7_42.

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Pollock, A. M. T., F. Haberl, and M. F. Corcoran. "The ROSAT Pspc Survey of the Wolf-Rayet Stars." In Wolf-Rayet Stars: Binaries, Colliding Winds, Evolution, 512–17. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0205-6_109.

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Ohya, Shin’ichi, and Yasuo Yoshioka. "Correction of X-Ray Diffraction Profiles Measured by PSPC System." In Advances in X-Ray Analysis, 397–402. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-9996-4_44.

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James, M. R., and E. B. S. Pardue. "X-Ray Diffraction Focusing Circle Errors for a PSPC Based System." In International Conference on Residual Stresses, 117–22. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-1143-7_17.

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Israel, G. L., A. Treves, L. Stella, L. Angelini, N. E. White, T. Kallman, S. Covino, and P. Giommi. "First Results from a Systematic Search for New X-ray Pulsators in ROSAT PSPC Fields." In The Many Faces of Neutron Stars, 411–17. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-015-9139-3_24.

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Mu, Meng, Linghua Guo, Nan Li, Cejian Ma, Jindou Xu, and Tingwen Ding. "Research on Embedding Environment of Digital Watermark Resistant to Print-Scan and Print-Camera (PSPC)." In Advances in Graphic Communication, Printing and Packaging Technology and Materials, 199–203. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0503-1_30.

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Ulrich, M. H., and S. Molendi. "High S/N ROSAT-PSPC Observations of the Quasar PG 1116+215: Power Law Shape of the Soft X-Ray Spectrum." In Multi-Wavelength Continuum Emission of AGN, 197–200. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-010-9537-2_28.

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Reichert, G. A., R. F. Mushotzky, and A. V. Filippenko. "ROSAT PSPC Observations of NGC 3079 (Poster paper)." In Mass-Transfer Induced Activity in Galaxies, 302–3. Cambridge University Press, 1994. http://dx.doi.org/10.1017/cbo9780511564789.065.

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Karachanskaya, Elena. "Invariants for a Dynamical System with Strong Random Perturbations." In Advances in Dynamical Systems Theory, Models, Algorithms and Applications. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96235.

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In this chapter we consider the invariant method for stochastic system with strong perturbations, and its application to many different tasks related to dynamical systems with invariants. This theory allows constructing the mathematical model (deterministic and stochastic) of actual process if it has invariant functions. These models have a kind of jump-diffusion equations system (stochastic differential Itô equations with a Wiener and a Poisson paths). We show that an invariant function (with probability 1) for stochastic dynamical system under strong perturbations exists. We consider a programmed control with Prob. 1 for stochastic dynamical systems – PSP1. We study the construction of stochastic models with invariant function based on deterministic model with invariant one and show the results of numerical simulation. The concept of a first integral for stochastic differential equation Itô introduce by V. Doobko, and the generalized Itô – Wentzell formula for jump-diffusion function proved us, play the key role for this research.
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"Innovation protecting ballast tanks of new ships against corrosion: An IMO PSPC-compliant Portuguese-born new coating concept." In Maritime Engineering and Technology, 275–82. CRC Press, 2012. http://dx.doi.org/10.1201/b12726-41.

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Тези доповідей конференцій з теми "PSPC1"

1

Mohankumar, Kumaravel, Rupesh Shrestha, and Stephen Safe. "Abstract 2428: NR4A1 ligands inhibits PSPC1 regulated EMT and stemness markers in breast, lung and liver cancer cells." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2428.

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Shinoda, Takeshi, Takashi Tanaka, and Kenta Morimitsu. "Development of a Quantity Determination Method of Blasting off Conditions." In SNAME Maritime Convention. SNAME, 2022. http://dx.doi.org/10.5957/smc-2022-059.

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The International Maritime Organization (IMO) has developed a performance standard for protective coatings (PSPC). Despite the fact that the regulation has been in existence for about 10 years, many shipyards continue to receive claims while inspecting the quality of each process in the coating stage. In particular, claims relating to the blasting off procedure are breaking the following coating process. In this study, we established a quantity determination method for measuring the blasting off condition of pre-coated steel plate for PSPC during the coating stage of ship production and reflect on the method for creating a prototype portable measurement instrument.
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Supper, Rodrigo. "ROSAT PSPC observation of M31." In The evolution of X-ray binaries. AIP, 1994. http://dx.doi.org/10.1063/1.45950.

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Gilmore, Diane M., and C. Megan Urry. "The ROSAT PSPC spectrum of PKS2155−304." In The soft x-ray cosmos: ROSAT science symposium and data analysis workshop. AIP, 1994. http://dx.doi.org/10.1063/1.46662.

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Breen, Jeffrey O., and Somak Raychaudhury. "ROSAT PSPC observations of the Shapley Supercluster." In The soft x-ray cosmos: ROSAT science symposium and data analysis workshop. AIP, 1994. http://dx.doi.org/10.1063/1.46689.

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Sun, X., H. Li, E. E. Fenimore, and Q. D. Wang. "X-ray flashes in ROSAT PSPC data." In GAMMA-RAY BURSTS. ASCE, 1998. http://dx.doi.org/10.1063/1.55469.

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Sambruna, Rita M., C. Megan Urry, John Stocke, Eric Perlman, Ron Kollgaard, Eric Feigelson, Diana Worrall, Paolo Padovani, Laura Maraschi, and Aldo Treves. "PSPC observations of the 1 Jy BL Lacs." In The soft x-ray cosmos: ROSAT science symposium and data analysis workshop. AIP, 1994. http://dx.doi.org/10.1063/1.46656.

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Carr, Michael J., Evert J. A. Meurs, and John P. Cunniffe. "Simulation of Hardness Ratio grids for the ROSAT PSPC." In ADA-III - Astronomical Data Analysis III Conference. BCS Learning & Development, 2004. http://dx.doi.org/10.14236/ewic/ada-iii2004.12.

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Azevedo, J. "Innovation Achieving IMO PSPC Compliance: A Game-Changer Example." In Marine & Offshore Coatings. RINA, 2010. http://dx.doi.org/10.3940/rina.coat.2010.05.

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Loewenstein, M., and R. Petre. "PSPC observations of the NGC 3607 group of galaxies." In The soft x-ray cosmos: ROSAT science symposium and data analysis workshop. AIP, 1994. http://dx.doi.org/10.1063/1.46686.

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