Дисертації з теми "PS2V"
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Hickman, Oliver. "The role of WFDC1/ps20 in prostate cancer." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-wfdc1ps20-in-prostate-cancer(36c77d56-4793-452c-aa1c-ca9379cb7127).html.
Повний текст джерелаАнотація:
In prostate cancer (PCa), stromal tissues co-evolve through reciprocal interactions with the tumour to support tumour growth and suppress the immune response. WFDC1/ps20 is a secreted whey acid protein (WAP) four-disulphide core (WFDC) family member highly expressed within the prostate stroma. Ps20 expression has been frequently observed to be down-regulated or lost in cancers including in prostate cancer, and numerous lines of evidence suggest that ps20 has intrinsic growth suppressive function in numerous tumour model systems. However, ps20 remains biochemically uncharacterised and the mechanisms by which it functions are unknown. WFDC1/ps20 is expressed in numerous mRNA and protein isoforms some of which result from proteolytic cleavage. These post-translational modifications affect the ability of the protein to inhibit the proliferation of PCa cells. We demonstrated that ps20 undergoes oligomerisation by transglutaminase, and crosslinking to fibronectin. We show that ps20 is cleaved by cathepsin L, which while failing to abrogate function of the protein, does liberate cross-linked ps20 from solid phase fibronectin. We show that ps20 binds to glycosaminoglycans (GAG) and interacts with cell surfaces in a GAG dependent manner. To further investigate the cellular effects of ps20 we overexpressed ps20 in PCa cell lines. Transgenic overexpression of WFDC1/ps20 reduced proliferation in WPMY-1 cells, and conditioned media (CM) from these cells had potent pro-apoptotic effects on a range of PCa cell lines. Whole genome differential transcriptome analysis of WPMY-1-EV v WPMY-1-ps20FL/WPMY-1-ps20TR cells identified numerous factors, including IL-8, IL-32, COX2, and SerpinF1 to be upregulated in WPMY-1 cells. Addition of a COX2 inhibitor reversed the suppressive effect of WPMY-1-ps20 CM, suggesting that expression of ps20 in the prostate stroma can regulate growth of epithelial and other tissues through the prostaglandin synthase pathway. Lastly, using ps20 overexpression in WPMY-1 prostate stromal cells, we demonstrated that CM from ps20 expressing cells inhibits proliferation of CD4 and CD8 T cells. Using depletion of ps20 from CM we show that suppression is indirectly mediated. We show that ps20 expression in WPMY-1 cell CM inhibits both anti-CD3/28 and IL-7/15 dependent T cell. However no effect on the secretion of IFNγ or expression of common T cell activation markers is observed. We demonstrate that the suppression of T cell proliferation is partly due to enhanced COX-2 activity.
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Gajdušek, Miroslav. "Monitor PSV a vysokofrekvenčního výkonu." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218619.
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This work deals with analysis methods continuous measuring systems for measurement standing wave ratio and high frequency power. Reflectometr, provision measuring standing wawe ratio, works in range frequence VHF (145 MHz, 443 MHz), for this width working frequence is used construction reflectometer with directive lead. Measurer HF power works into range 1kW. Further is in work go through problems communications bus for transmission data from unit monitor SWR a HF power into score modulus. With regard to high frequency interference is choice serial communication RS-485 , which is immune against disturbance. Further is designed evaluation unit MASTER, unit SLAVE and modules for measurement power and SWR. In finish is build up the firmware for units.
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Toussaint, Kai. "Atemmechanik unter Atmung mit PSV und PIPAP." [S.l.] : [s.n.], 2000. http://www.sub.uni-hamburg.de/disse/550/Disse.pdf.
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Bogaert, Thierry Andre Olivier Eddy. "Molecular characterization of the Drosophila PS2 antigen." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328565.
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Thureen, Dean Richard. "The complete nucleotide sequence and characterization of the Psittacid herpesvirus 1 (PsHV-1) genome." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 129 p, 2007. http://proquest.umi.com/pqdlink?did=1251898411&Fmt=7&clientId=79356&RQT=309&VName=PQD.
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Hedröd, Fredrik. "Interfacemodul för kommunikation mellan CAN-bus och USB/PS2 eller RS232." Thesis, University West, Department of Technology, Mathematics and Computer Science, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-373.
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På uppdrag av innovationsföretaget EmpirBus AB skulle en produkt utvecklas. Projektet innefattade utvecklingsprocessen ända ifrån ide till slutprodukt. Syftet var att utveckla ett gränssnitt för kommunikation mellan CAN-bus och USB/PS2 eller RS232. Gränssnittet sammankopplas med ett CAN-bussbaserat elsystem för marina installationer. Produktens uppgift var att utföra bildskärmsväxlingar på informationsskärmar ombord på fartyg. Genom att sända ett kommando till en bildskärmsväxel innehållande information om till vilken bild som skall växlas fram. Projektet gick enligt plan och en färdig produkt blev slutresultatet, benämnd UPS-B Ver. 1.0.
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Sivapathasundram, Sudhersha. "The effect of nitrogen starvation on PS2 in the cyanobacterium synechococcus." Thesis, Liverpool John Moores University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275823.
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Asciutti, Augusto César Spadaccia 1988. "Papel da PS20/WFDC1 no desenvolvimento prostático e regulação da distribuição das células p63 positivas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317553.
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Orientador: Hernandes Faustino de CarvalhoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: Introdução: Durante o desenvolvimento e a vida adulta de um organismo, células troncoindiferenciadas, capazes de dar origem a um ou mais tipos celulares, proliferam e se diferenciam para, tanto produzir os tecidos de um organismo em desenvolvimento, quanto repor células perdidas pelo envelhecimento, doença ou injúria. Essas células residem em um nicho especializado contendo células diferenciadas e elementos responsáveis por manter o estado predominantemente quiescente. Acredita-se que as células tronco da próstata contribuam para o desenvolvimento de câncer através da desregulação dos elementos do nicho. ps20 é um elemento secretado por células musculares lisas da próstata, o qual demonstra capacidade de inibir o crescimento da linhagem de células prostáticas cancerígenas PC3 em cultura. Evidências sugerem uma possível relação entre ps20 com a adesão celular. No entanto, seu funcionamento é pouco conhecido. Objetivos: Analisar o efeito do silenciamento do gene WFDC1/ps20 sobre o comportamento das células p63+ e arquitetura tecidual durante o desenvolvimento prostático pós-natal. Materiais e métodos: Próstatas ventrais de ratos Wistar recém nascidos foram cultivadas sobre membranas flutuantes permeáveis, na presença de RNA de interferência para reduzir a expressão de ps20. Os órgãos foram cultivados por sete dias e em seguida analisados através da contagem da formação de estruturas epiteliais, colorações histológicas, imunohistoquímica e PCR em Tempo Real. Resultados: O silenciamento de WFDC1/ps20 levou a uma redução de 36% na quantidade de mRNA de WFDC1/ps20. Foi observada redução no número de pontas de ductos epiteliais entre o segundo e quarto dia cultura e entre o quarto e sétimo dia. A análise histológica revelou ductos com ramificação reduzida e com as pontas mais dilatadas, em resposta a redução de WFDC1/ps20. Foi observada polarização celular prejudicada e cavitação reduzida. A imunohistoquímica para p63 revelou que os níveis reduzidos de ps20 promoveram a concentração das células p63+ nas pontas dilatadas dos ductos epiteliais. Real Time PCR revelou que o silenciamento do gene WFDC1/ps20 promoveu um aumento de nove vezes na quantidade do mRNA de MMP9.Discussão: O silenciamento de WFDC1/ps20afetou o desenvolvimento prostático com um efeito sem ambiguidade no comportamento das células basais p63+, como representado pelo seu acumulo nas pontas dos ductos e diminuição ao longo dos ductos estendidos. O tratamento também prejudicou a polarização de células luminais e comprometeu a cavitação.O conteúdo elevado de mRNA de MMP9 pode estar relacionado com o acumulo da proteína e a degradação descontrolada da matriz extracelular ao redor pontas dos ductos, levando ao fenótipo dilatado. Como a degradação correta da matriz em locais específicos é requerida para a formação do ponto de ramificação, é sugerido que a ps20 regula o balanço da atividade de MMP9 necessária durante o desenvolvimento prostático. Essa ideia coloca o sistema uPA/uPAR acima da regulação e ativação de MMP9.Conclusões:A redução deWFDC1/ps20comprometeu a morfogênese em ramos, polarização das células epiteliais e cavitação. Esses aspectos estão associados com a desestabilização do comportamento das células p63+, como sugerido pelo seu acumulo nas pontas dilatadas e diminuição do compartimento de células basais ao longo dos ductos estendidos
Abstract: Introduction: During the development and adult life of an organism, undifferentiated stem cells, capable of giving rise to one or more cell types in an adult organism, proliferate and differentiate to both produce the tissues of an developing organism and replace cells lost by aging, disease or injury. These cells reside in a specialized niche containing differentiated cells and elements responsible for maintaining their predominantly quiescent state. Prostate stem cells are believed to contribute to cancer development via deregulation of niche elements. ps20 is a protein secreted by prostate smooth muscle cells which was shown to inhibit the growth of prostatic PC3 cancer cell line in culture. Evidences exist favoring a possible relationship between ps20 and cell adhesion. However its functioning is still poorly known. Objectives: Analyze the effect of the silencing of the WFDC1/ps20 gene in the behavior of p63-positive cells and tissue architecture during the post-natal prostatic development. Materials and methods: Ventral prostate of newborn Wistar rats were cultured on floating permeable membranes, in the presence of small interference RNA to reduce ps20 expression. The organs were cultured for seven days, and then analyzed by counting of epithelial structures formation, histological and immunohistochemical staining and Real Time PCR. Results: The silencing of WFDC1/ps20 led to a 36% reduction in WFDC1/ps20 mRNA amount. It was observed reduction in the number of epithelial duct tips between the second and fourth day of culture, and between the fourth and seventh day. Histological analysis revealed reduced branching and dilated tips in response toWFDC1/ps20knocking down. It was observed hindered polarization and reduced cavitation. Immunohistochemistry for p63 revealed that reduced levels of ps20 promoted the concentration of p63+ cells at the enlarged ductal tips. Real Time PCR revealed that the knocking down the WFDC1/ps20 gene promoted a 9-fold increase in the amount of MMP9 mRNA. Discussion: The silencing of WFDC1/ps20affected prostate development with an unambiguous effect on p63+ cells behavior, as represented by their accumulation at the ductal tips and depletion along the extended ducts. The treatment also hampered the differentiation of luminal cells and compromised cavitation. The increased MMP9 mRNA content might be correlated with the accumulation of the protein and uncontrolled degradation of the extracellular matrix around the duct tips, leading to the dilated phenotype. Since the correct degradation of the matrix in specific sites is required for the branch point formation we suggest that ps20 regulates the balance for MMP9 activity required during prostate development. This idea places the uPA/uPAR system upstream of MMP-9 regulation and activation. Conclusions: The reduction in the WFDC1/ps20expressioncompromised branching morphogenesis, epithelial cell polarization and cavitation. These aspects are associated with a destabilization of p63+cell behavior, as suggested by their accumulation at the dilated tips and depletion from the basal cell compartment along the extended ducts
Mestrado
Biologia Celular
Mestre em Biologia Celular e Estrutural
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Schwartz, Laurent. "Le mRNA PS2 dans le cancer du sein : signification pronostique, implications thérapeutiques." Université Louis Pasteur (Strasbourg) (1971-2008), 1985. http://www.theses.fr/1985STR1M293.
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Vásquez, Cristian Andrés Morales. "A methodology to select the electric propulsion system for Platform Supply Vessels (PSV)." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/3/3135/tde-26122014-164655/.
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The present work proposes a methodology to define the electric propulsion system for PSVs. This methodology was applied to a case study: the conceptual design of a PSV for operation at the pre-salt fields at Santos basin. First, four different alternatives of electric propulsion systems for the PSV are presented and sized. The first one has induction motors as main propulsion motors, the second one has synchronous motors as main propulsion motors; the third and fourth alternatives are the same as the first and second, respectively, with a batteries bank connected to the main switchboard. Each of the four arrangements was contemplated with two options for Diesel generators: high speed and medium speed generator sets. The mass, volume, fuel consumption, exhaust gases emissions and reference capital costs for each arrangement are estimated and analyzed. Moreover, an economic analysis through the Net Present Value (NPV) is performed. The methodology ends with the Analytic Hierarchy Process (AHP) to support the decision making procedure. Some of the parameters obtained for each arrangement (mass, volume, fuel consumption, exhaust gases and NPV) are used as criteria and sub-criteria for selection. Two scenarios are evaluated, the first scenario gives more importance to the financial component of the design; the second scenario sets the exhaust gases emissions as the more significant parameter. The results were different, the arrangements 1 and 2 with medium speed Diesel generator sets appear as the most suitable option from the economical point of view; whereas the arrangements with batteries and high speed Diesel gensets are the best options to reduce the exhaust emissions.O presente trabalho propôs uma metodologia para definir o sistema de propulsão elétrica para PSVs. A metodologia foi aplicada para um caso estudo: o projeto conceitual de um PSV para operar nos campos do pré-sal na Bacia de Santos. Primeiramente, as quatro diferentes alternativas de sistemas de propulsão elétrica para PSV são apresentadas e dimensionadas. A primeira alternativa tem motores de indução como motores de propulsão principal, a segunda alternativa tem motores síncronos como motores de propulsão principal; a terceira e quarta alternativas são as mesmas que a primeira e a segunda, respectivamente, com um banco de baterias conectado ao quadro principal. Cada um dos quatro arranjos foi considerado com duas opções para Diesel geradores: Diesel geradores de alta e média rotação. A massa, volumem, consumo de combustível, emissão de gases e os custos capitais de referência para cada arranjo são estimados e analisados. Adicionalmente, uma análise económica usando o Valor Presente Líquido (VPL) é feita. A metodologia finaliza com o Analytic Hierarchy Process (AHP) para apoiar o processo de escolha de alternativa. Alguns dos parâmetros obtidos para cada arranjo (massa, volumem, consumo de combustível, gases poluentes e o VPL) são utilizados como critérios de seleção. Dois cenários são avaliados, o primeiro cenário dá maior importância à parte financeira do projeto, o segundo cenário estabelece as emissões de gases poluentes como o parâmetro mais significativo. Os resultados foram diferentes, os arranjos 1 e 2 com Diesel geradores de média rotação se apresentam como a opção mais adequada desde o ponto de vista econômico; enquanto os arranjos com baterias e Diesel geradores de alta rotação são a melhor opção para reduzir as emissões de gases poluentes.
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Paula, Danielle Bezerra de. "A constru??o de posicionamento valorativo no cronotopo do PSV- 2008 da UFRN." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/16213.
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Previous issue date: 2011-06-09Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Situ?e dans le domaine de la Linguistique Appliqu?e (CELANI, 1998; MOITA LOPES, 2004, 2006, 2009), cette recherche documentaire fait partie d‟une approche qualitative-interpr?tative qui privil?gie une perspective socio-historique (FREITAS, 2002, 2007; ROJO, 2006). Le but principal de ce travail est d‟analyser comment l‟interlocution a lieu dans les lettres argumentatives produites par 10 sujets-?nonciateurs ayant particip? au processus de s?lection du ?vestibular? d‟UFRN, appel? ici le chronotope du PSV-2008. Pour cela, les objectifs sp?cifiques qui guident cette recherche consistent ? analyser les modes d‟assimilation du discours de l‟autre par le candidat, ? identifier les positions axiologiques r?sultant des formes du processus interlocutif, et ? construire une vision du sujet-?nonciateur sur la base des choix de valeurs de l‟?nonciateur et des relations espace-temps qui constituent l‟?nonciateur et l‟interlocuteur. Quant ? la th?orie, la recherche est fond?e principalement sur la notion de chronotope de Bakhtin une cat?gorie qui d?coule de la th?orie du roman et probl?matis?e par Amorim (2004) en articulation avec les r?flexions th?oriques de Geraldi (1997, 1999, 2006), Britto (2006) et Antunes (2005, 2006) sur le processus d‟?criture les relations dialogiques, la responsivit? et les voix sociales (BAKHTIN, 1990, 2003, 2008; BAKHTIN/VOLOCHINOV, 2006) qui sont travers?es par la conception dialogique du langage. L‟analyse nous a permis d‟identifier, principalement, deux d?bats dialogiques, dont le premier confronte le candidat ? la dissertation et le second, ? des interlocuteurs mentionn?s dans la proposition. Les sujets ont formul? leurs ?nonc?s sur un ton d‟indignation, en critiquant ce que l‟interlocuteur avait exprim?. Les candidats ont fait appel ? la formation d‟un sc?nario d‟espoir, de cr?dulit?, de respect et d‟?thique, conforme ? la dignit? de l‟?tre humain. Ces r?sultats mettent en ?vidence la fa?on dont des sujets multiples et h?t?rog?nes, ins?r?s dans la dimension de la vie, prennent position ? l‟int?rieur des pratiques discursives, face aux coordonn?es d‟espace et de temps
Situada na Lingu?stica Aplicada (CELANI, 1998; MOITA LOPES, 2004, 2006, 2009), esta pesquisa documental se inscreve em uma abordagem qualitativo-interpretativista de perspectiva s?cio-hist?rica (FREITAS, 2002, 2007; ROJO, 2006). O objetivo geral consiste em analisar como ocorre a interlocu??o nas cartas argumentativas produzidas por 10 sujeitos-enunciadores que participaram do Processo Seletivo Vestibular de 2008 da UFRN, aqui denominado cronotopo do PSV-2008. Para isso, os objetivos espec?ficos que orientam esta pesquisa s?o: analisar os modos de assimila??o do discurso alheio ao dizer do vestibulando; identificar posicionamentos axiol?gicos decorrentes das formas do processo interlocutivo observadas; e construir uma vis?o de sujeito-enunciador com base nas escolhas valorativas do enunciador e no tempo-espa?o que constituem as rela??es entre enunciador e interlocutor. Quanto ao aporte te?rico, a investiga??o se fundamenta, principalmente, nas no??es bakhtinianas de cronotopo categoria advinda da teoria do romance e problematizada por Amorim (2004) em articula??o com as reflex?es te?ricas de Geraldi (1997, 1999, 2006), Britto (2006) e Antunes (2005, 2006) sobre o processo de escrita , rela??es dial?gicas, responsividade e vozes sociais (BAKHTIN, 1990, 2003, 2008; BAKHTIN/VOLOCHINOV, 2006) as quais s?o atravessadas pela concep??o dial?gica da linguagem. Pela an?lise, identificamos, principalmente, dois debates dial?gicos, um travado com a prova de reda??o, outro com um dos interlocutores apontados na proposta. Os sujeitos carregaram seus enunciados de um tom de indigna??o, criticando o que expressou o interlocutor. Os vestibulandos recorreram ? forma??o de um cen?rio de esperan?a, credulidade, respeito, ?tica, natureza digna do ser humano. Essas constata??es permitem vislumbrar como sujeitos m?ltiplos e heterog?neos, inseridos no mundo da vida, tomam posi??o nas pr?ticas discursivas face ?s coordenadas temporais e espaciais
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Ahadi, Mohammad Reza. "Development of an alternative test procedure to 'BS 812' for accelerated polishing of roadstones." Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324632.
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de, Sá Braga Oliveira André. "Efeitos da ventilação mecânica controlada e da ventilação por pressão de suporte sobre o músculo diafragma de ratos." Universidade Federal de Pernambuco, 2010. https://repositorio.ufpe.br/handle/123456789/8147.
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Previous issue date: 2010A assistência ventilatória mecânica (AVM) controlada induz profundas alterações na musculatura diafragmática, causando a chamada disfunção diafragmática induzida pela ventilação mecânica (DDIV). Essas alterações parecem poder ser atenuadas quando utilizados modos com participação da atividade diafragmática, como o de Pressão de Suporte (PSV). O objetivo do trabalho foi avaliar os efeitos do modo ventilatório controlado por pressão controlada (PCV-C) e do modo PSV sobre a histologia e morfometria do músculo diafragma de ratos. Ratos (n = 18) da linhagem Wistar foram incluídos nesse estudo prospectivo. Após injeção intraperitoneal de anestésico e sedativo, os ratos foram distribuídos no grupo controle (RE) e para receber AVM por 6 horas no modo PCV-C e no modo PSV. Após esse período, os animais foram eutanasiados, o diafragma retirado e encaminhado para a análise histológica e morfométrica. Os resultados revelaram uma redução da área das fibras musculares de 15% no grupo PCV-C em comparação ao controle (p<0,001) e de 10% quando comparado ao grupo PSV (p<0,05). Já com relação ao diâmetro menor das fibras musculares observou-se uma redução de 9% do grupo PCV-C em comparação ao controle (p<0,001) e de 6% em relação ao grupo PSV (p<0,05). Quando avaliada a área dos mionúcleos, notou-se uma redução de 16% desse parâmetro no grupo PCV-C, comparado ao PSV (p<0,05). Não houve diferença significativa no perímetro dos mionúcleos entre os grupos estudados (p>0,05). O grupo PCV-C apresentou atrofia muscular em um período curto de ventilação mecânica. O modo PSV parece atenuar os efeitos da DDIV, sendo uma alternativa eficiente no controle da atrofia muscular decorrente do uso do suporte ventilatório
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Gillesby, Bradley Edward. "The human breast cancer prognostic marker, pS2 and its regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ31145.pdf.
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Zhu, Tong 1971. "Develop real-time multitasking system and client/server based windows protocol for IBM PC/PS2." Thesis, The University of Arizona, 1992. http://hdl.handle.net/10150/278250.
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As Local Area Networks becoming increasingly popular, the need to develop protocols for remote login, client/server based peer to peer connections, and event driven windows protocol for IBM PC/PS2 is ever greater. This thesis is primary devoted to the development of a real-time multitasking system for the IBM PC/PS2, and a client/server, event driven Windows protocol similar to X-Window protocol available in computers based on Unix platform. In addition, features such as interprocess communication queues, virtual windows, heap managers which are necessities in a distributed environment are provided also. Program developer may include this multitasking program in the kernel of the PC network operating system such as Novell Netware, and Microsoft Lan Manager. Consequently, a multitasking kernel is developed to provide dynamic tasking spawning, fast task switching, and MS-DOS independent dynamic memory allocation. In addition, a window manager based on this multitasking kernel is developed to manage dialog windows or tasking windows in a distributed environment. Windows may be sent across the network and be displayed remotely.
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Wang, Da-Gong. "Expression of oncogenes and a breast cancer associated protein, pS2, in human neuroendocrine tumours : implication for tumourigenesis." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361236.
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Robertson, Laura, LaShay Jennings, Huili Hong, Karin Keith, and Chih-Che Tai. "Forces and Motion (PS2): An Integrated K–8 Hands-On Approach Supporting the NGSS and CCSS ELA." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/769.
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Tai, Chih-Che, Renee Rice Moran, Karin Keith, Laura Robertson, and Diane O'Neal. "Forces and Motion (PS2): An Integrated K-8 Hands-On Approach Supporting the NGSS and CCSS ELA." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/3239.
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Català, Oltra Lluís. "Fonaments de la identitat territorial amb especial atenció a la identitat nacional. El cas valencià: discursos polítics sobre la identitat valenciana entre els militants de base del Bloc, EUPV i PSPV-PSOE." Doctoral thesis, Universidad de Alicante, 2012. http://hdl.handle.net/10045/28677.
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Martin, Valérie. "La méthylation de l'ADN : facteur épigénétique contrôlant la transcription du gène pS2 (TFFI) dans les cancers du sein." Lyon 1, 1996. http://www.theses.fr/1996LYO10315.
Повний текст джерелаАнотація:
La proteine ps2 est exprimee dans la glande mammaire sous la dependance des strogenes. Il s'agit d'un marqueur tumoral dont la detection constitue un facteur de bon pronostic dans les cancers du sein. Les resultats obtenus au cours de cette these ont montre que l'expression du gene ps2, est sous la dependance de l'etat de methylation de sa region regulatrice. En effet, dans les lignees cellulaires, il semble que la demethylation de cette region, associee a la surexpression de res (obtenus par transfection transitoire) soient necessaire a l'induction de la transcription du gene. In vivo, l'analyse de biopsies par southern blot, a montre que le pourcentage de molecules demethyles etait proportionnel a la quantite de transcrit ps2. Afin d'elargir cette etude a l'ensemble des cpgs presents dans la region analysee, une technique de sequencage genomique a ete developpee. L'analyse en composantes multiples des resultats obtenus a permis la mise en evidence d'une correlation entre la demethylation de la region promotrice du gene ps2, plus particulierement de la zone contenant l'ere, et la transcription du gene. A ce stade des recherches, il semblait donc probable que la methylation exercait un effet inhibiteur direct dans la fixation des recepteurs aux strogenes a l'element de reponse du gene ps2. Les experiences de retard de migration sur gel n'ont pas confirme cette hypothese en outre, elles ont permis d'identifier une nouvelle proteine de 46 kda, possedant une forte affinite pour l'ere du gene ps2 non methylee. Il s'agit d'une proteine ubiquitaire qui reconnait un motif palindromique, de type ere, contenant des sites cpgs. Des etudes complementaires seront necessaires afin d'approfondir son role dans la regulation de la transcription du gene ps2
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Fuertes, André Filipe Gonçalves. "Análise económica da adoção de navios autónomos no sector Offshore Oil & Gas, uma perspetiva de futuro." Master's thesis, Instituto Superior de Economia e Gestão, 2020. http://hdl.handle.net/10400.5/20146.
Повний текст джерелаАнотація:
Mestrado em Gestão e Estratégia IndustrialA introdução de navios autónomos capazes de navegar independentemente sem tripulação a bordo parece ser uma realidade próxima na indústria marítima. A aposta neste tipo de tecnologia promete benefícios económicos pela redução de custos com tripulações, operações mais seguras, melhores eficiências energéticas e melhorias ao nível da construção naval. Neste trabalho, partiu-se de um navio PSV convencional de grau um na escala de Autonomia IMO que existe fisicamente e opera no sector Offshore Oil & Gas, com tripulação a bordo. Fazendo uma análise económica se o mesmo fosse um navio autónomo de grau três na mesma escala IMO sem qualquer tripulação a bordo, e nas mesmas condições de operação. O estudo segue a metodologia do projeto MUNIN, que fez uma análise análoga para um navio graneleiro. O que o presente estudo traz de inovador, é não só focar a analise no sector Offshore Oil & Gas, mas sobretudo utilizar valores reais de custos operacionais, de viagem e de capital de um navio que existe fisicamente em lugar de modelos teóricos de navios. A análise centra-se sobretudo no apuramento dos custos do navio nas duas condições, enquanto navio convencional, e na sua condição de autónomo. No que concerne às receitas, o navio opera a uma taxa de frete diária fixa contratada, que se considerou que depende dos mercados de brokerage e por essa razão a analise é centrada nos custos. As conclusões demonstram que o navio autónomo permite vantagens nas três dimensões de custos analisadas comparativamente ao navio convencional.
The introduction of autonomous ships capable of sailing independently without crew on board seems to be a close reality in the maritime industry. The investment in this type of technology promises economic benefits by reducing crew cost, safer operations, increase fuel efficiency, improvements in shipbuilding. In this research we started with a PSV ship that exists physically and operates in the offshore Oil & Gas Sector, of grade one on the IMO autonomy scale, crew manned. Performed an economic analysis of the ship operating under the same conditions but supposing it was in grade three on the IMO autonomy scale, without crew. The study follows the MUNIN project methodology, which performed similar analysis for a bulk carrier. The innovation the present research brings is not only the focus on the offshore Oil & Gas sector, but above all the use of real data of a real ship, when so far this analysis was based only in theoretical models. The analysis focuses mainly on determining the costs in both ship conditions separately as a conventional ship and in its autonomous condition. Regarding revenues, the ship is operating in a fixed daily rate freight, which was considered to be depending on brokerage markets, for this reason the analysis is centred on costs. The conclusions show that the autonomous vessel is cost advantageous in the three dimensions regarding the conventional ship.
info:eu-repo/semantics/publishedVersion
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Akeke, Jean-Charles. "Pronostic des cancers du sein traités par chirurgie première ; corrélation de la protéine pS2 aux autres facteurs pronostiques dans une série de trois cent quarante trois malades." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2M057.
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Ribieras, Stéphane. "Altération des profils de méthylation de l'ADN dans les cancers humains : implication dans le contrôle de l'expression du gène pS2." Lyon 1, 1995. http://www.theses.fr/1995LYO10236.
Повний текст джерелаАнотація:
Une alteration des profils de methylation de l'adn est frequemment observee dans les tumeurs humaines. La methylation de plusieurs loci de la region chromosomique 11p et du locus 17p13. 3 a ete analysee par southern blots dans les adenocarcinomes mammaires et coliques. Il existe des sites, certains specifiques du type tumoral, dont la methylation est particulierement modifiee dans ces cancers. De plus, l'alteration de la methylation est detectable a un stade precoce de la cancerogenese dans les tumeurs du sein. La methylation du gene ps2 (estrogen-induced breast cancer associated protein gene) a ete etudiee par southern blots dans les cancers du sein. Les hypomethylations de la region 5' de ce gene semblent specifiques de sous-classes de cancers du sein. Dans les echantillons exprimant ps2 cette sequence est demethylee, et des experiences realisees in vitro sont aussi en faveur d'une implication de la methylation dans le controle de l'expression du gene. Cependant, des experiences de retard de migration sur gel indiquent que la fixation des recepteurs d'oestrogenes sur leurs elements de reponse n'est pas affectee par la methylation. L'ensemble de ces donnees suggerent que des changements specifiques de methylation peuvent etre impliques dans le controle de genes tumeur-specifiques
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Houlné, Guy. "Structure et expression des genes codant pour les apoproteines des antennes collectrices de photons ps2 et ps1 chez euglena gracilis." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13169.
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Houlné, Guy. "Structure et expression des gènes codant pour les apoprotéines des antennes collectrices de photons PS2 et PS1 chez Euglena gracilis." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376143878.
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Lefebvre, Olivier. "La stromelysine-3 et ps2 : deux genes surexprimes dans le cancer du sein. etudes de leur role physiologique chez la souris." Université Louis Pasteur (Strasbourg) (1971-2008), 1995. http://www.theses.fr/1995STR13122.
Повний текст джерелаАнотація:
Le cancer du sein represente la premiere cause de mortalite pour les femmes premenopausees dans les pays industrialises et sa frequence ne cesse d'augmenter. La stromelysine-3 (st3) et ps2, sont deux genes surexprimes dans le cancer du sein et qui pourraient jouer un role dans la progression tumorale. Mon travail de recherche consista a etudier le role physiologique de ces deux proteines. Pour cela j'ai isole les adnc de ces deux genes chez la souris et j'ai etudie leur expression durant l'embryogenese et dans les tissus adultes. Enfin, pour determiner leur fonction, j'ai etabli des lignees de souris deficientes pour l'expression de la st3 ou de ps2, par invalidation de leur gene respectif par recombinaison homologue. Malgre tous les sites d'expression decris, les souris st3 ou ps2 mutantes sont tout a fait normales et fertiles. Nous poursuivons maintenant nos investigations quant a la recherche d'un eventuel phenotype dans nos differentes lignees de souris
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Dhaliwal, Jagroop. "Regulators of Adult Hippocampal Neurogenesis." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35712.
Повний текст джерелаАнотація:
One mechanism of plasticity within the adult mammalian brain is the dynamic process of adult neurogenesis that is functionally important in physiological and pathological conditions. During this process, neurons develop from adult neural stem cells (NSCs) via intermediate neural progenitors (NPCs) through several processes including proliferation, survival, differentiation, migration and integration. Despite neurogenesis during development sharing these same processes, there is growing evidence highlighting unique mechanisms that regulate adult versus embryonic neurogenesis.
The studies in this thesis test the cell-intrinsic function of genes that have defined roles in embryonic neurogenesis and undefined roles in adult hippocampal neurogenesis using a combination of transgenic inducible mice and in vivo retroviral techniques. The first study examines the microtubule associated protein Doublecortin (DCX), which is transiently expressed by NPCs and is critical for neuronal migration. Our results show that, in the context of adult hippocampal neurogenesis, DCX is not required for the survival or differentiation of the NPCs within the subgranular zone (SGZ). The second study examines the functional role of the autophagy-associated gene 5 (Atg5) which is critical for embryonic neurogenesis and survival. Our findings demonstrate that the intracellular recycling process of autophagy is active throughout maturation of adult hippocampal NPCs and that ablation of Atg5 produces a drastic reduction in NPC survival, without altering the neuronal fate of these cells. The third study examines the requirement of the familial-Alzheimer’s disease associated genes, presenilin 1 and presenilin 2 (PS1 & PS2), which are critical for embryonic NSC maintenance and differentiation. Similar to the findings with DCX, our results demonstrate that presenilins are dispensable for adult neurogenesis. Altogether, these studies add to the growing evidence suggesting differences in the regulation of adult versus embryonic neurogenesis, and highlight autophagy as a novel regulator of survival for adult generated granule neurons in the hippocampus.
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Andersson, Erik. "Historiebruk och historiemedvetande i Venezuelas Förenade Socialistiska Partis Libro Rojo." Thesis, Södertörns högskola, Institutionen för historia och samtidsstudier, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-19104.
Повний текст джерелаАнотація:
This thesis examines the use of history, historical narratives and the relation to Venezuelan historical consciousness in Libro Rojo, a publication of The Unified Socialist Party of Venezuela (PSUV). It consists of four parts: an introduction, a declaration of principles, statutes and finally what is called the programmatical bases (bases programaticas) of the party. A starting point for this thesis is that this is an under prioritized area of research about the Bolivarian revolution in Venezuela. It aims to show the centrality of history in these fundamental documents of the biggest left-wing party in Latin America. The thesis finds that symbolically charged historical figures – mainly national icons of Venezuela´s struggle for national liberation - are mobilized to back up contemporary aspirations and influence public perception of what kind of future is possible and desirable. Libro Rojo structures the relationship between past, present and future in order to influence historical consciousness. It also finds that Libro Rojo constructs a vision of socialism which aims to show that the ideas and actions of Venezuela´s symbolically charged historical figures are compatible with the ideas of 19th and 20th century western Marxism. An illustration of this is the reference to Peruvian Marxist José Carlos Mariáteguí and his saying that socialism on the American continent can neither be an imitation nor a copy of foreign models, but a heroic creation of the people. Furthermore in Libro Rojo, the ideas of liberation theology, Christianity as well as "all universal and humanist thought" are evoked as foundations for the contemporary aspirations of the PSUV. The present is situated within a context of contemporary history in which themes such as the struggle of the peoples against neoliberalism and the threats to the survival of humanity due to climate changes, economic crisis and war are central. It describes a near future in which humanity will have a choice: between its salvation and flourishing through socialism, or its extinction through world capitalism.
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Lamar, Deborah da Costa. "Expressão de proteína parasporina 2 (PS2) de bacillus thuringiensis em células de inseto e análise de sua toxicidade para células tumorais e de insetos." reponame:Repositório Institucional da UnB, 2016. http://repositorio.unb.br/handle/10482/21428.
Повний текст джерелаАнотація:
Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Patologia Molecular, 2016.Submitted by Fernanda Percia França (fernandafranca@bce.unb.br) on 2016-09-01T14:41:43Z No. of bitstreams: 1 2016_DeborahdaCostaLamar.pdf: 2872393 bytes, checksum: 9d419a56e6761d5e59959dc81459806d (MD5)
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Bacillus thuringiensis é uma bactéria Gram positiva, produtora de cristais protéicos ou δ-endotoxinas (toxinas Cry e Cyt) durante a fase de esporulação. As toxinas. Cry apresentam atividade inseticida específica, e as toxinas Cyt apresentam atividade citolítica inespecífica. Algumas proteínas produzidas por B. thuringiensis durante a fase de esporulação que não apresentam caráter inseticida, mas apresentam-se tóxica para células tumorais foram descritas. Essas proteínas receberam o nome de Parasporinas (PS), devido à capacidade de produzir cristais paraesporais e até o momento são classificadas em seis tipos (PS1-PS6). Baculovírus são vírus de insetos usados no controle biológico de pragas da agricultura, porém também têm sido muito utilizados como vetores de expressão de proteínas heterólogas em células de inseto. No presente trabalho, o gene ps2 foi montado, por meio de PCR, através de fragmentos sintetizados a partir de uma sequência lotada no banco de dados, e o produto de PCR foi clonado em um vetor de transferência para construção de um baculovírus recombinante. Após obtenção do vírus recombinante, observou-se que células SF9 quando infectadas com vAcPS2, morriam em um tempo curto de infecção, quando comparado com células infectadas com o vírus selvagem. Após purificação, solubilização e ativação da toxina PS2 recombinante, ensaios de viabilidade celular foram feitos com linhagens de células tumorais, câncer mamário (MCF-7) e câncer mamário metastático (MDA-MB-231), células não tumorais humanas (fibroblastos) e células de inseto (Sf9), confirmando a atividade tóxica de PS2 apenas para as células tumorais. _________________________________________________________________________________________________ ABSTRACT
Bacillus thunringiensis is a Gram positive bacterium that produces crystal forming proteins called δ-endotoxins (Cry and Cyt toxins), during sporulation phase. Cry toxins show specific insecticidal activity, and Cyt toxins shows non-specific cytolitic activity. Some proteins of B. thuringiensis produced during sporulation have not shown insecticidal activity, but a specific toxic activity to some cancer cells. These proteins were called Parasporins (PS) due to their ability to form paraporal crystals and they are divided in six groups (PS1-PS6). Baculoviruses are insect viruses that have been widely used as biological control of agricultural pests, but also as expression vectors of heterologous proteins in insect cells. In this work, the gene ps2, constructed by PCR, trough fragments synthetized using a gene sequence from a database and cloned in a transfer vector for recombinant virus construction After recombinant virus construction we observed that SF9 cells died faster than cells infected with the wild-type virus. After purification, solubilization and activation of the heterologous protein, cell viability assays was performed with cancer cell lines, breast cancer (MCF-7), metastatic brest cancer (MDA-MB-231), non-tumor human cells (fibroblasts) and insect cells (Sf9) confirming PS2 toxic activity only to cancer cells.
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Koudelka, Tomáš. "Tenkovrstvé emulzní úpravy." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2014. http://www.nusl.cz/ntk/nusl-226948.
Повний текст джерелаАнотація:
This thesis is focused on microsurfacing technology. The theoretical part describes modern trends especially in the field of coloured surfaces and special system Flexiplast®. The practical part presents the results of conducted tests, particularly tests of breaking time, cohesion, determination of wearing and determination of friction after polishing. The key advantage is that it specifies which aggregates, which were taken from quarries through the Czech Republic, are convenient for this specialized technology. It was verified that RAP material suits use in microsurfacing. Furthermore, colour mixtures are viable for practical application which was confirmed by tests in the laboratory and trial lying as well. Special use of technology in the system Etanpalst and pictures which show field work are presented.
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Kazemi, Kazem. "Imagerie sismique de structures pétrolières plissées et faillées du Zagros (Iran), à partir de données de surface et de puits." Phd thesis, Université de Cergy Pontoise, 2009. http://tel.archives-ouvertes.fr/tel-00403617.
Повний текст джерелаАнотація:
Le Champ d'Aghajari est situé dans le Dezful, une des zones du Zagros structurée par d'importantes failles de charriage, et contenant la majeure partie des champs d'huile iraniens. La formation calcaire de l'Asmari, datant de la fin Oligocène à début Miocène, constitue l'une des principales couches réservoir du Sud-Ouest de l'Iran, avec un historique de production de plus d'un demi siècle pour plusieurs champs de cette région. L'objectif de cette thèse est de mieux comprendre la structure de ce champ, connu principalement par les puits de production,grâce à la première sismique 3D récemment acquise et en intégrant les informations fournies par la sismique de puits. Le problème principal est que le toit et la base du réservoir n'apparaît pas dans la zone à huile du réservoir, où les interfaces sont très pentés. Étant donné l'importance des pendages (environ 40°), les réflexions en sismique de puits zéro offset sont attendues principalement sur les composantes horizontales, ce qui rend impératif le traitement des 3 composantes. Une méthode originale d'orientation des 3 composantes est employée et les résultats confirment la
présence de réflecteurs pentés, en accord avec la sismique de surface sur le côté Est de la structure.
Plusieurs nouvelles approches d'imagerie ont été appliquées afin de comprendre et résoudre les problèmes d'illumination de la zone réservoir. Nous avons appliqué pour la première fois en terrestre l'approche « Beyond Dix » de CGGVERITAS qui permet de construire un modèle profondeur à partir de pendages et courbure résiduelles move-out mesurée sur les images PSTM (pré-stack time migration). Les résultats migrés en profondeur sont plus précis dans le recouvrement mais la zone réservoir n'est pas améliorée. La raison en est que
les images temps ne permettent pas de mesurer les pendages et courbures résiduelles dans la zone d'intérêt en raison d'une part de fort multiples et d'autre part d'u niveau de bruit important.
Une nouvelle technique prototype de migration PSTM a été développée à l' IFP, permettant une sélection de l'azimut, du pendage géologique et la recherche automatique du meilleur pendage locale. L'application de ces techniques est très encourageante et montre qu'il est possible d'extraire les réflexions pentées en améliorant le rapport signal sur bruit de la migration elle-même.
L'étude additionnelle d'exploration d'une autre structure anticlinale du Zagros, par utilisation combinée de sismique de surface, des données de puits, du PSV et de l'information géologique, illustre comment l'analyse intégrée des données permet d'améliorer la compréhension des structures profondes, et de contribuer à prendre de meilleures décisions de forage, dans la mesure où cette intégration est suffisamment rapide.
Au final, dans le Zagros, la sismique de surface est définitivement une bonne méthode d'exploration structurale, mais son application aux études fines de réservoir n'a pas été démontrée, malgré les efforts effectués.
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Le, Bégat Soazig, and Raúl Madariaga. "Etude de l'anisotropie sismique a partir de psv et de pso : utilisation des temps d'arrivees des ondes quasi-p et de la birefringence des ondes quasi-s." Paris 6, 1995. http://www.theses.fr/1995PA066368.
Повний текст джерелаАнотація:
La caracterisation de l'anisotropie sismique offre la possibilite de comprendre le role joue par les fractures et les fluides dans les processus tectoniques, de controler les caracteristiques des reservoirs geothermiques ou d'hydrocarbures, ou de detailler la structure de la croute terrestre. La presence d'anisotropie peut etre mise en evidence par l'etude des variations angulaires de la vitesse des ondes p, ou par l'analyse de la birefringence des ondes s. Une technique d'inversion des temps de trajet est developpee afin d'obtenir l'information vehiculee par les ondes p. La propagation de ces ondes en milieu transverse isotrope est calculee par la theorie des rais associee a des methodes perturbatives. Le probleme inverse est ensuite resolu par decomposition en valeurs singulieres. Les tests de sensibilite des temps aux parametres inverses, ont montre la necessite d'introduire de l'information a priori dans l'inversion. De meme, des exemples synthetiques ont souligne l'importance de disposer d'une bonne couverture angulaire et azimutale de la structure etudiee. L'application de cette methode tomographique a des donnees de puits du bassin parisien, a permis de detecter la presence d'anisotropie dans le cretace (argiles et sables), ainsi que dans les niveaux reservoirs. L'origine de l'anisotropie est attribuee a l'existence de micro-fractures verticales orientees dans la direction du champ de contrainte regional. La birefringence des ondes s est etudiee sur le site de soultz-sous-forets, avant et pendant des injections d'eau en puits profond, dans le but d'identifier les zones de flux dans les systemes de fractures naturelles. Avant injection, le socle granitique apparait homogene et isotrope, et la presence de failles majeures a ete detectee ; de l'anisotropie est par ailleurs observee dans les sediments superficiels. Au cours de l'injection, les proprietes isotropes du massif ne sont pas affectees. Cependant, des modifications des temps de trajet semblent indiquer l'accentuation d'une structure heterogene, liee a la percolation du fluide injecte
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Tang, Zhenzhong. "Polissage et adhérence des chaussées routières." Phd thesis, Ecole des Ponts ParisTech, 2007. http://pastel.archives-ouvertes.fr/pastel-00003623.
Повний текст джерелаАнотація:
La présente thèse concerne l'adhérence des pneumatiques avec les chaussées routières, et la possibilité de prévoir son évolution à l'aide d'essais de laboratoire et de modélisations. Tout d'abord, une méthodologie originale de polissage et de mesure de l'adhérence en laboratoire est présentée ; elle s'appuie sur la machine de Wehner et Schulze, développée en Allemagne. Grâce à elle, on peut mesurer l'évolution du coefficient de frottement avec la durée du polissage. Des chantiers routiers sont suivis dans le temps, afin de comparer la simulation en laboratoire et l'évolution réelle de l'adhérence. Parallèlement à la simulation expérimentale, des lois d'évolution sont établies. Un modèle à cinq paramètres est tout d'abord proposé, que l'on tente de relier aux caractéristiques des granulats (PSV, diamètre maximal, microtexture, etc.). Ensuite, un modèle plus physique est ébauché, explicitant les mécanismes de vieillissement et de décapage du bitume, et de polissage des granulats. Un coefficient d'équivalence entre le trafic poids lourd et le nombre de cycles d'usure en laboratoire est proposé, devant permettre à terme de choisir entre différents matériaux de couche de surface, et de prévoir l'évolution de l'adhérence d'une chaussée neuve. Enfin, les profils de surface sont examinés à différents états de polissage, dans le but de relier l'évolution de l'adhérence aux paramètres de rugosité, et aux caractéristiques des granulats (PSV, MDE, LA).
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Hempel, Wilca Barbosa. "A importância do princípio protetor-recebedor para o desenvolvimento ambientalmente sustentável: o caso do Ceará." reponame:Repositório Institucional da UFC, 2006. http://www.repositorio.ufc.br/handle/riufc/16744.
Повний текст джерелаАнотація:
HEMPEL, Wilca Barbosa. A importância do princípio protetor-recebedor para o desenvolvimento ambientalmente sustentável: o caso do Ceará. 2006. 146 f. : Dissertação (mestrado) - Universidade Federal do Ceará, Pró-Reitoria de Pesquisa e Pós-Graduação, Mestrado em Desenvolvimento e Meio Ambiente, Fortaleza-CE, 2006Submitted by Nádja Goes (nmoraissoares@gmail.com) on 2016-05-12T12:58:42Z No. of bitstreams: 1 2006_dis_wbhempel.pdf: 5562195 bytes, checksum: 1b38ad3b68d07e49ceaa7d8bf94946a7 (MD5)
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The present dissertation is aimed at proposing an operational model for the environmentally sustainable development of the state of Ceará using the “Green Municipality Certification Program” as a tool for the evaluation of local environmental policies combined with the Ecological “ICMS” as a financial compensation mechanism, based on the Protector-Receiver principle. The development of science in the 17-th century contributed to the rapid decline of human mortality and the maintenance of high birth rates, provoking an unseen growth in the world population. The development of science and technology allied to the process of industrialization, was responsible for major changes in the lives of human beings and its relations to the natural world. This ongoing growth is leading to an increase in the level of stress towards the biosphere contributing to environmental destruction with disastrous consequences. The 20-th century witnessed the beginning of another cycle of mass extinction in the history of life on earth caused by men. The rapid growth of environmental problems lead many scientists to think of and to discuss a new type of development, that should promote long-term human progress on the planet. One of the pillars of sustainabledevelopment is the Protector-Receiver principle, which compensates financially, as an incentive for services produced, those who protect natural resources, representing a symbol of economic justice. Analysis tools where used, to favor through results of quality analysis, the proposal of a model for sustainable development, including local and regional specificities. The “Ecological ICMS”, the result of redistribution of the “ICMS” to the municipalities by the State, without increasing taxes, can be adjusted to the already existing economic instruments, representing one of the most convenient options to finance environmental policies within the current context. The “Green Municipality Certification Program” was established by the state Government of Ceará and is aimed at promoting the implementation of environmental policies by the municipalities. The “Green Municipality Program” certifies the municipalities that implement public policies that contribute to environmental protection and to the increase of the quality of life of present and future generations. An operating model for the environmentally sustainable development is presented, based on the “Green Municipality Certification Program” and the Ecological “ICMS” applied to the state of Ceará, and if taken on board, will be able to establish itself as an important tool to be used by the Government, as an incentive to environmentally sustainable economic growth.
A presente dissertação tem como objetivo principal propor um Modelo Operacional de Desenvolvimento Ambientalmente Sustentável para o Estado do Ceará, utilizando o Programa Selo Município Verde como ferramenta de avaliação das políticas municipais e o ICMS Ecológico como mecanismo de compensação financeira, alicerçado no Princípio Protetor- Recebedor. Pesquisas científicas desenvolvidas e aplicadas no século dezessete fizeram com que a taxa de mortalidade humana declinasse de forma abrupta, sendo mantida constante a taxa de natalidade; isso provocou um crescimento sem precedentes na população mundial. O desenvolvimento da ciência e da tecnologia, aliado ao processo de industrialização, foi responsável pelo surgimento de mudanças na vida dos seres humanos e nas suas relações como mundo natural. Esse crescimento continuado, vem provocando aumento no nível de estresse da biosfera e uma degradação ambiental cada vez mais preocupante, com conseqüências desastrosas. O século vinte testemunhou o início de mais um grande evento de extinção na história da vida na Terra e o causador, desta vez, é o próprio Homem. A emergência e a gravidade dos problemas ambientais fizeram com que inúmeros cientistas e estudiosos começassem a discutir e a pensar um novo tipo de desenvolvimento, capaz de fomentar o progresso humano em todo o planeta e por tempo indeterminado. O Desenvolvimento Sustentável surge tendo como um dos seus alicerces o Princípio Protetor-Recebedor, que compensa financeiramente, como incentivo pelo serviço prestado, aquele que protege um bem natural, representando um símbolo de justiça econômica. Foram utilizadas ferramentas de análise, espacial e temporal, de maneira a favorecer, por meio dos resultados da análise qualitativa, a proposição de Modelo de Desenvolvimento Sustentável, com a consideração das especificidades regionais e locais. O ICMS Ecológico, resultante de uma redistribuição do ICMS arrecadado pelo Estado, para os municípios, sem aumento da carga tributária, adapta-se aos instrumentos econômicos já existentes, representando uma das mais convenientes opções de financiamento das políticas ambientais no contexto atual. O Programa Selo Município Verde (PSMV) foi criado pelo Governo do Estado do Ceará para incentivar a implementação das normas que regulamentam a questão ambiental. O “Selo Município Verde” é um distintivo que identifica os municípios que implementam políticas públicas que salvaguardam o meio ambiente e proporcionam melhor qualidade de vida para as presentes e futuras gerações. Assim sendo, apresenta-se um Modelo Operacional de Desenvolvimento Ambientalmente Sustentável, tendo como mecanismos de apoio o Programa Selo Município Verde em conjunto com o instrumento econômico ICMS Ecológico, para o Estado do Ceará, que, se adotado, deve se constituir em um importante instrumento a ser utilizado pelo governo, como incentivo ao crescimento econômico com sustentabilidade ambiental.
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Hempel, Wilca Barbosa. "A importÃncia do princÃpio protetor-recebedor para o desenvolvimento ambientalmente sustentÃvel: o caso do CearÃ." Universidade Federal do CearÃ, 2006. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2116.
Повний текст джерелаАнотація:
FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgicoA presente dissertaÃÃo tem como objetivo principal propor um Modelo Operacional de Desenvolvimento Ambientalmente SustentÃvel para o Estado do CearÃ, utilizando o Programa Selo MunicÃpio Verde como ferramenta de avaliaÃÃo das polÃticas municipais e o ICMS EcolÃgico como mecanismo de compensaÃÃo financeira, alicerÃado no PrincÃpio Protetor- Recebedor. Pesquisas cientÃficas desenvolvidas e aplicadas no sÃculo dezessete fizeram com que a taxa de mortalidade humana declinasse de forma abrupta, sendo mantida constante a taxa de natalidade; isso provocou um crescimento sem precedentes na populaÃÃo mundial. O desenvolvimento da ciÃncia e da tecnologia, aliado ao processo de industrializaÃÃo, foi responsÃvel pelo surgimento de mudanÃas na vida dos seres humanos e nas suas relaÃÃes como mundo natural. Esse crescimento continuado, vem provocando aumento no nÃvel de estresse da biosfera e uma degradaÃÃo ambiental cada vez mais preocupante, com conseqÃÃncias desastrosas. O sÃculo vinte testemunhou o inÃcio de mais um grande evento de extinÃÃo na histÃria da vida na Terra e o causador, desta vez, à o prÃprio Homem. A emergÃncia e a gravidade dos problemas ambientais fizeram com que inÃmeros cientistas e estudiosos comeÃassem a discutir e a pensar um novo tipo de desenvolvimento, capaz de fomentar o progresso humano em todo o planeta e por tempo indeterminado. O Desenvolvimento SustentÃvel surge tendo como um dos seus alicerces o PrincÃpio Protetor-Recebedor, que compensa financeiramente, como incentivo pelo serviÃo prestado, aquele que protege um bem natural, representando um sÃmbolo de justiÃa econÃmica. Foram utilizadas ferramentas de anÃlise, espacial e temporal, de maneira a favorecer, por meio dos resultados da anÃlise qualitativa, a proposiÃÃo de Modelo de Desenvolvimento SustentÃvel, com a consideraÃÃo das especificidades regionais e locais. O ICMS EcolÃgico, resultante de uma redistribuiÃÃo do ICMS arrecadado pelo Estado, para os municÃpios, sem aumento da carga tributÃria, adapta-se aos instrumentos econÃmicos jà existentes, representando uma das mais convenientes opÃÃes de financiamento das polÃticas ambientais no contexto atual. O Programa Selo MunicÃpio Verde (PSMV) foi criado pelo Governo do Estado do Cearà para incentivar a implementaÃÃo das normas que regulamentam a questÃo ambiental. O âSelo MunicÃpio Verdeâ à um distintivo que identifica os municÃpios que implementam polÃticas pÃblicas que salvaguardam o meio ambiente e proporcionam melhor qualidade de vida para as presentes e futuras geraÃÃes. Assim sendo, apresenta-se um Modelo Operacional de Desenvolvimento Ambientalmente SustentÃvel, tendo como mecanismos de apoio o Programa Selo MunicÃpio Verde em conjunto com o instrumento econÃmico ICMS EcolÃgico, para o Estado do CearÃ, que, se adotado, deve se constituir em um importante instrumento a ser utilizado pelo governo, como incentivo ao crescimento econÃmico com sustentabilidade ambiental.
The present dissertation is aimed at proposing an operational model for the environmentally sustainable development of the state of Cearà using the âGreen Municipality Certification Programâ as a tool for the evaluation of local environmental policies combined with the Ecological âICMSâ as a financial compensation mechanism, based on the Protector-Receiver principle. The development of science in the 17-th century contributed to the rapid decline of human mortality and the maintenance of high birth rates, provoking an unseen growth in the world population. The development of science and technology allied to the process of industrialization, was responsible for major changes in the lives of human beings and its relations to the natural world. This ongoing growth is leading to an increase in the level of stress towards the biosphere contributing to environmental destruction with disastrous consequences. The 20-th century witnessed the beginning of another cycle of mass extinction in the history of life on earth caused by men. The rapid growth of environmental problems lead many scientists to think of and to discuss a new type of development, that should promote long-term human progress on the planet. One of the pillars of sustainabledevelopment is the Protector-Receiver principle, which compensates financially, as an incentive for services produced, those who protect natural resources, representing a symbol of economic justice. Analysis tools where used, to favor through results of quality analysis, the proposal of a model for sustainable development, including local and regional specificities. The âEcological ICMSâ, the result of redistribution of the âICMSâ to the municipalities by the State, without increasing taxes, can be adjusted to the already existing economic instruments, representing one of the most convenient options to finance environmental policies within the current context. The âGreen Municipality Certification Programâ was established by the state Government of Cearà and is aimed at promoting the implementation of environmental policies by the municipalities. The âGreen Municipality Programâ certifies the municipalities that implement public policies that contribute to environmental protection and to the increase of the quality of life of present and future generations. An operating model for the environmentally sustainable development is presented, based on the âGreen Municipality Certification Programâ and the Ecological âICMSâ applied to the state of CearÃ, and if taken on board, will be able to establish itself as an important tool to be used by the Government, as an incentive to environmentally sustainable economic growth.
36
Baron, Sylvain. "Dialogue entre le recepteur des oestrogènes alpha et le facteur de croissance IGF-I dans l'activation transcriptionnelle des cellules cancéreuses mammaires." Phd thesis, Université Paul Sabatier - Toulouse III, 2007. http://tel.archives-ouvertes.fr/tel-00155908.
Повний текст джерелаАнотація:
Le contrôle de la prolifération des cellules cancéreuses mammaires est un phénomène complexe. Les oestrogènes jouent un rôle important dans le contrôle de cette prolifération. L'action des oestrogènes se fait via le récepteur des oestrogènes α (REα), un facteur de transcription qui complexé à l'oestradiol, est capable de moduler la transcription de nombreux gènes impliqués dans la prolifération, l'apoptose ou la différentiation cellulaire. L'utilisation d'anti-hormones qui sont des inhibiteurs compétitifs de l'œstradiol bloquent la prolifération des cellules cancéreuses mammaires. Malheureusement les patientes métastatiques traitées par ce type de molécules développent systématiquement une résistance aux thérapies anti-hormonales. Les facteurs de croissance, tels que l'EGF ou l'IGF-I, qui entraînent une activation du REα de manière ligand indépendante pourraient être responsable de l'apparition de ces phénomènes de résistance. L'étude des voies d'activation du REα par ces facteurs de croissance est donc importante. Le facteur de croissance IGF-I participe au contrôle du développement de la glande mammaire pendant l'embryogenèse et il a une activité œstrogène dans les cellules cancéreuses mammaires. Cette activité oestrogène de l'IGF-I requiert l'expression du récepteur des oestrogènes α (REα), mais on ne connaît pas les mécanismes moléculaires mis en jeu. Nous avons démontré que sur un promoteur complexe tel que le promoteur du gène oestrogéno régulé pS2/TFF1, qui contient un site de liaison au REα et un site de liaison au complexe AP1, l'activation transcriptionnelle de ce gène requiert le REα et le complexe AP1. L'ensemble de ces travaux a permis de mettre en évidence un mécanisme d'action original et non conventionnel du REΑ, en absence d'hormone. En présence du facteur de croissance IGF-I, le REα est nécessaire mais pas suffisant pour activer la transcription et le complexe AP1 joue un rôle aussi important que le REα dans l'activation transcriptionnelle du gène pS2/TFF1. Ce complexe AP1, ou les voies conduisant à son activation pourrait donc être des cibles thérapeutique de choix pour le traitement du cancer du sein.
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Vilardell, Nogales Mireia. "Desarrollo de nuevos métodos estadísticos y/o bioinformáticos para la detección de variaciones en el número de copias (CNVs) y su relación con enfermedades humanas." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7117.
Повний текст джерелаАнотація:
El descubrimiento de las duplicaciones segmentarias (DS) o Low Copy Repeats (LCRs) ha permitido definir nuevos mecanismos evolutivos mediados, en gran parte, por duplicación génica. Las DS son responsables de reordenamientos que pueden ser submicróscopicos dando lugar a pequeñas pérdidas o ganancias de material genómico. La elucidación sobre su implicación y relación en enfermedades humanas ha generado la necesidad de crear nuevos instrumentos de medida que permitan rastrear el genoma humano a una mayor resolución que la conseguida mediante cariotipo normal. Una de estas nuevas técnicas se denomina matrices aCGH. En esta tesis doctoral se han desarrollado métodos que permiten la optimización de la técnica durante el proceso de fabricación e hibridación y que, a su vez, pueden ser aplicados sobre los métodos actuales de detección de CNVs incrementando su sensibilidad y especificidad. Además se ha realizado una comparación entre plataformas aCGH así como un análisis transcriptómico global de muestras alteradas, tomando como modelo de estudio el síndrome de Williams-Beuren que está caracterizado por una deleción parcial en la banda 7q11.23. A parte de ganancias y pérdidas de fragmentos de material génico, las DSs pueden generar copias de genes que pueden acumular cambios respecto el original (PSVs). Algunos de estas PSVs ya se han identificado como patogénicas por ello es de gran utilidad su estudio.
38
Dufek, Ivo. "Automatický anténní analyzátor." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218324.
Повний текст джерелаАнотація:
This project is dealing with methods of measuring impedances of the antenna systems in the frequency range from the low frequencies to the very high frequencies. There is a discussion about different methods of measuring impedance and each technique is critically evaluated. In terms of this project is compared few types of the professional antenna analyzers. According to this comparison there was made the concept of my own antenna analyzer. There is a detailed description of the design of this device’s important parts including software equipment. Designed instrument has been built and tested.
39
Cheng, Xiwen. "The Functional Study of Transcriptional Corepressor G-Protein Suppressor 2 (GPS2) and Tumor Suppressor Promyelocytic Leukemia (PML)." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1277741995.
Повний текст джерела
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Virieux, Jean. "Séismes : rupture et onde." Phd thesis, Université Paris-Diderot - Paris VII, 1986. http://tel.archives-ouvertes.fr/tel-00653208.
Повний текст джерелаАнотація:
Le travail présenté dans ce mémoire s'intéresse à la quantification des processus physiques liés aux séismes de la rupture initiale à la propagation des ondes jusqu'à la zone cible où des stations d'enregistrement permettent de mieux contraindre le mouvement du sol. L'estimation quantitative a été réalisée grâce à une technique numérique de simulation que sont les différences finies. Un schéma en grille alternée permet de réduire fortement les instabilités associées aux ondes, d'optimiser le temps de calcul et la mémoire nécessaire aux problèmes dynamiques. Les processus physiques à la source sismique sont complexes car s'expriment comme un phénomène de frottement dans un milieu hétérogène. Cette thèse aborde des configurations bidimensionnelles et tridimensionnelles et montre qu'il existe une loi d'échelle numérique venant de la singularité des champs en pointe de faille. Dans le cas purement cassant, il n'existe pas d'échelle caractéristique conduisant à affirmer que la solution numérique ne converge pas vers la solution théorique avec les discrétisations associées à la méthode utilisées: la solution numérique ne peut exprimer avec assez de résolution la singularité. L'introduction d'une zone de faiblesse en pointe de faille permet d'introduire une échelle et de rendre le problème plus facile à résoudre. Il est ensuite abordé le problème de la propagation en milieux hétérogènes dans des configurations unidimensionnelles, bidimensionnelles sachant que le cas 3D peut l'être aussi mais réclame des moyens informatiques notables. On notera que le schéma hétérogène proposé sur une grille en quinconce permet de décrire les ondes d'une manière précise quand leur énergie devient notable. Cela est vrai à une interface liquide/solide par exemple où l'onde S est confinée dans le milieu solide sans provoquer d'instabilités dans le milieu liquide. La reconstruction du milieu est une étape importante en association avec la localisation des séismes. Des techniques d'optimisation nouvelles permettent d'envisager la reconstruction des propriétés du milieu via la forme d'onde et non plus uniquement via les temps d'arrivée. L'effort numérique est important et seulement le cas acoustique dans des configurations simples est introduit et permet de comprendre la non-linéarité du problème d'imagerie. Nous voyons ainsi dans cette thèse qu'il est possible de contraindre la physique à la source sismique et durant la propagation des ondes sismiques grâce à une modélisation précise des équations différentielles partielles et des conditions aux limites qui caractérisent cette physique. En l'associant aux observations des signaux sismiques aux stations, il sera possible dans le future de mieux expliquer les phénomènes sismiques observés.
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BHOLA, GAURAV. "INDIA AND CHINA SPACE PROGRAMS: FROM GENESIS OF SPACE TECHNOLOGIES TO MAJOR SPACE PROGRAMS AND WHAT THAT MEANS FOR THE INTERNATI." Master's thesis, University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3276.
Повний текст джерелаАнотація:
The Indian and Chinese space programs have evolved into technologically advanced vehicles of national prestige and international competition for developed nations. The programs continue to evolve with impetus that India and China will have the same space capabilities as the United States with in the coming years. This will present new challenges to the international community in spheres civilian, to space and military applications and their residual benefits.M.A.
Department of Political Science
Sciences
Political Science MA
42
Moussavi, Nik Seyyed Hani. "Analysing the biological function of PS2V: an aberrant splicing phenomenon or evolutionarily conserved mechanism in Alzheimer’s disease." Thesis, 2015. http://hdl.handle.net/2440/100187.
Повний текст джерелаАнотація:
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with pathologies such as neuron loss, glial cell proliferation, extracellular deposition of senile plaques from the accumulation of amyloid beta (Aβ) peptides and deposition of intracellular neurofibrillary tangles. Aβ is generated from the cleavage of the Amyloid Precursor Protein (AβPP) by two different types of aspartyl proteases, β- and γ-secretase. The majorities of AD cases are sporadic and have a late onset. Mutations in genes encoding APP, PRESENILIN1 and 2 (PSEN1 and PSEN2) cause an autosomal dominant inherited form of the disease with an early onset known as familial AD. In some sporadic cases an aberrant splice variant of PSEN2 named PS2V is formed that can be found in inclusion bodies in the brain. PS2V results from the binding of the High Mobility Group A1a (HMGA1a) protein close to the splice donor site of exon 5 of PSEN2. HMGA1a is widely expressed during embryo development but not in adults. Its expression can be induced in adult neurons by hypoxia/oxidative stress and it is commonly reactivated in many types of cancer. Zebrafish embryos have a unique combination of characteristics that allows genetic manipulation and analysis of molecular pathways implicated in neurodegenerative diseases. The embryos are numerous, macroscopic, external to the mother and transparent making them easy to inject and observe. Changes in different aspects of their rapid development can be used as bioassays to assess gene activity. In chapter II of this thesis, we present evidence from a number of different assays that acute exposure to hypoxia or chemical mimicry of hypoxia increases oxidative stress in zebrafish brain tissue. We demonstrated that intracellular ROS levels are significantly increased in zebrafish brains exposed to actual hypoxia or chemical mimicry of hypoxia using NaN3 hypoxia. In chapter III of this thesis we examine the evolutionary conservation of PS2V and investigate its effect on gene expression profiles, γ- secretase activity. In this chapter we show evidence for an important role of PRESENILIN genes in cellular responses to low oxygen (hypoxia). The PS2V splicing isoform of human PSEN2 transcripts is generated under hypoxic conditions through induction of HMGA1a that binds to exon 5 sequence in transcripts. We show that an orthologue of the PS2V isoform, PS1IV, exists in the zebrafish. The novel splice product of zebrafish psen1, “PS1IV” codes for a much smaller peptide then PS2V but, nevertheless is capable of boosting γ-secretase activity. In chapter IV we utilised microarray to analysis the function of PS1IV in modulation of a wide variety of gene products. We show that that production of this PS1IV is accompanied with activation of stress response genes such as interleukin 1 Beta (IL1B), tyrosine hydroxylase (TH), and myelin expression factor (MYEF) which leads to triggering apoptosis and autophagy. We also demonstrate that PS1IV is an important contributor in signalling pathways associated with AD. In chapter V we investigated the guinea pig, Cavia porcellus, as a model for Alzheimer’s disease (AD), both in terms of the conservation of genes involved in AD and the regulatory responses of these to a known AD risk factor - high cholesterol intake. We demonstrate that PS2V formation is up-regulated by hypoxia and a high-cholesterol diet while, consistent with observations in humans, Aβ concentrations are raised in some brain regions but not others. We have previously identified two paralogues (co-orthologues) of MAPT in zebrafish, denoted mapta and maptb and have shown that both genes are expressed in the developing central nervous system. In chapter VI we extend our examination of expression of the zebrafish tau co-orthologues to study their response to actual hypoxia and chemical mimicry of hypoxia in explanted adult fish brains. We observed increases in the overall levels of both mapta and maptb transcripts due to specific increases in the levels of mapta 6R and maptb 4R transcript isoforms. This is consistent with dramatically decreased levels of transcripts of the zebrafish orthologue of the human TRA2B gene that codes for a splicing factor proposed to regulate alternative splicing of MAPT transcripts.Thesis (Ph.D.) (Research by Publication) -- University of Adelaide, School of Molecular and Biomedical Sciences, 2015.
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Marčeková, Mária. "Faktory ovplyvňujúce spôsob vedenia a chovánia psov na verejných priestranstvách v Brne." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-430224.
Повний текст джерелаАнотація:
The aim of the diploma thesis was to study factors influencing behavior of dogs in public spaces in Brno. 133 pairs of dogs were observed. The dog's gender, dog age, and age of the dog owner affected the interaction. The owner of the dog affected by the interaction. The dog's sex, dog age, and dog age influenced sniffing. All factors that were monitored influenced the play. The gender of the dog affected the marking behavior. The gender of the dog owner affected the threat. The dog's owner's gender affected bite occurrence.
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Toussaint, Kai [Verfasser]. "Atemmechanik unter Atmung mit PSV und PIPAP / Kai Toussaint." 2000. http://d-nb.info/964096706/34.
Повний текст джерела
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Aires, Marta Catarina Milhões. "Experiências de Ressonância Magnética Nuclear Pulsada, com o espectrómetro PS2-B." Master's thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/78279.
Повний текст джерела
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Aires, Marta Catarina Milhões. "Experiências de Ressonância Magnética Nuclear Pulsada, com o espectrómetro PS2-B." Dissertação, 2014. https://repositorio-aberto.up.pt/handle/10216/78279.
Повний текст джерела
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Rogers, Erin. "The Role of ps20 in Two Respiratory Virus Infections: MHV-1 and Influenza A/WSN/33 H1N1." Thesis, 2010. http://hdl.handle.net/1807/25906.
Повний текст джерелаАнотація:
The objective of this thesis was to examine the role of ps20 in virus infections. We provide evidence that MHV-1 infection resulted in increased lung viral titers in ps20-/- mice. These data highlight an antiviral role for ps20 in MHV-1 infection. We also observed an increase in the percentage of GR1+ neutrophils infiltrating the BAL and in the lung draining lymph node of ps20-/- mice, on day 2 post-infection. In vitro, gene expression analysis identified an increase in expression of CXCL1 and CXCL2 in MHV-1 infected ps20-/- fibroblasts. These data suggest a role for ps20 in regulating neutrophil chemotactic factors, and migration. Next, we examined influenza A/WSN/33, and provide evidence that ps20 functions as a proviral factor. In vivo, ps20-/- mice infected with influenza A/WSN/33 exhibited decreased lung viral titers. These data suggest that ps20 functions as either a proviral or antiviral agent, dependent on the infecting virus.
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Amorim, Sara Filipa Cancela. "Conceção e Implementação de um Sistema de Controlo Interno na empresa PSV, Lda." Master's thesis, 2021. http://hdl.handle.net/10400.26/39080.
Повний текст джерелаАнотація:
O tecido empresarial português é composto, essencialmente, por micro, pequenas e
médias empresas. A sua grande maioria terá começado por uma micro ou pequena
empresa, em que o seu crescimento depende da existência de mecanismos de auxílio aos
órgãos de gestão, que lhes permita, a qualquer momento, obter informação fiável que
apoie a tomada de decisões e que garanta a salvaguarda dos ativos.
Neste contexto, a existência de um Sistema de Controlo Interno adequado tem vindo a
assumir um papel crescente na expansão das empresas.
Este projeto tem como principal objetivo conceber e implementar um Sistema de Controlo
Interno numa pequena empresa, a PSV, Lda. Para tal foi efetuada uma pesquisa
bibliográfica sobre os principais conceitos, objetivos, tipos, princípios e limitações do
controlo interno.
Paralelamente foram elaborados cinco questionários sobre a área de compras, gestão de
pessoal, inventários, meios financeiros líquidos e vendas, que permitiram conhecer a
forma de funcionamento das diversas áreas da empresa e efetuar um levantamento das
lacunas existentes.
Foram então propostas melhorias ao Sistema de Controlo Interno existente na empresa
em estudo, em que algumas delas já foram adotadas e postas em prática.
Este projeto pretende assim contribuir para o desenvolvimento de boas práticas de forma
a minimizar o risco e potenciar um nível de segurança razoável no que concerne ao
alcance dos objetivos da gerência.
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Glaesmer, Heide [Verfasser]. "Können Qualitätszirkel Kosten dämpfen? : Auswertung von Abrechnungsdaten niedergelassener Ärzte eines Qualitätssicherungsprojektes zur psychosomatischen Grundversorgung (PSGV) / von Heide Glaesmer." 2004. http://d-nb.info/972685197/34.
Повний текст джерела
50
Chang, Chien-chung, and 張鑑中. "Salmonella typhimurium virulence plasmid(pSTV)gene that enhances production of p40, a subunit of interleukin 12(IL-12)." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/28124417658273716429.
Повний текст джерелаАнотація:
碩士長庚大學
基礎醫學研究所
86
The S. typhimurium virulence plasmid(pSTV) was known to mediate depression of lymphocyte proliferation after S. typhimurium infect mice, but the mechanism of this depression was unknown. To explore the possibility that the depression might be established via interruption of cytokine production, the effect of pSTV on interleukin 12(IL-12) was investigated. When checked ex vivo, mouse peritoneal macrophages in a 24-well plate were mixed respectively with LPS and four strains of S. typhimurium [wild type OU5045, plasmidless OU5048, OU5584( OU5048/pOU102), and OU5381 (OU5048 /pOU206)---pOU102 and pOU206 were Tn5-inserted ] and IL-12 was measured kinetically. All strains equally induced minimal production of IL-12 and p35, a subunit of IL-12. However, OU5048 and OU5381 showed little effect on p40, the other subunit of IL-12, while LPS and the other two greatly increased the amount of p40. When checked in vivo, same all strains were injected intraperitoneally and p40 in terms of PCR amplified cDNA was measured kinetically in the washes, a similar result was observed. Moreover, OU5381 with a wild type allele ( a partial diploid ) was observed to restore the ability to enhance the p40 production. Thus pSTV carries gene that enhances the production of p40. IL-12 plays pivotal role in lymphocyte activation and proliferation. However, when produced excessively, the p40 dimer can antagonize the action of IL-12 by occupying the receptor of IL-12. Depression of lymphocyte proliferation was thus established.