Добірка наукової літератури з теми "Proteolytic assemblies"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Proteolytic assemblies".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Proteolytic assemblies"
Walz, J., A. J. Koster, T. Tamura, and W. Baumeister. "Macromolecular Assemblies Designed for Controlled Proteolysis." Microscopy and Microanalysis 4, S2 (July 1998): 980–81. http://dx.doi.org/10.1017/s1431927600025022.
Повний текст джерелаKoppen, Mirko, Metodi D. Metodiev, Giorgio Casari, Elena I. Rugarli, and Thomas Langer. "Variable and Tissue-Specific Subunit Composition of Mitochondrial m-AAA Protease Complexes Linked to Hereditary Spastic Paraplegia." Molecular and Cellular Biology 27, no. 2 (November 13, 2006): 758–67. http://dx.doi.org/10.1128/mcb.01470-06.
Повний текст джерелаAweida, Dina, and Shenhav Cohen. "Breakdown of Filamentous Myofibrils by the UPS–Step by Step." Biomolecules 11, no. 1 (January 15, 2021): 110. http://dx.doi.org/10.3390/biom11010110.
Повний текст джерелаYang, Dongsik, Hongjian He, and Bing Xu. "Enzyme-instructed morphological transition of the supramolecular assemblies of branched peptides." Beilstein Journal of Organic Chemistry 16 (November 4, 2020): 2709–18. http://dx.doi.org/10.3762/bjoc.16.221.
Повний текст джерелаOláh, Judit, Attila Lehotzky, Tibor Szénási, and Judit Ovádi. "Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein." Cells 10, no. 11 (October 27, 2021): 2909. http://dx.doi.org/10.3390/cells10112909.
Повний текст джерелаUskoković, V., M.-K. Kim, W. Li, and S. Habelitz. "Enzymatic processing of amelogenin during continuous crystallization of apatite." Journal of Materials Research 23, no. 12 (December 2008): 3184–95. http://dx.doi.org/10.1557/jmr.2008.0387.
Повний текст джерелаYang, Jin-Kyoung, Seon-Yeong Kwak, Su-Ji Jeon, Eunjin Lee, Jong-Min Ju, Hye-In Kim, Yoon-Sik Lee, and Jong-Ho Kim. "Proteolytic disassembly of peptide-mediated graphene oxide assemblies for turn-on fluorescence sensing of proteases." Nanoscale 8, no. 24 (2016): 12272–81. http://dx.doi.org/10.1039/c6nr02815b.
Повний текст джерелаErk, Inge, Jean-Claude Huet, Mariela Duarte, Stéphane Duquerroy, Felix Rey, Jean Cohen, and Jean Lepault. "A Zinc Ion Controls Assembly and Stability of the Major Capsid Protein of Rotavirus." Journal of Virology 77, no. 6 (March 15, 2003): 3595–601. http://dx.doi.org/10.1128/jvi.77.6.3595-3601.2003.
Повний текст джерелаHarkness, Robert W., Yuki Toyama, Zev A. Ripstein, Huaying Zhao, Alexander I. M. Sever, Qing Luan, Jacob P. Brady, Patricia L. Clark, Peter Schuck, and Lewis E. Kay. "Competing stress-dependent oligomerization pathways regulate self-assembly of the periplasmic protease-chaperone DegP." Proceedings of the National Academy of Sciences 118, no. 32 (August 6, 2021): e2109732118. http://dx.doi.org/10.1073/pnas.2109732118.
Повний текст джерелаTamara, Sem, Vojtech Franc, and Albert J. R. Heck. "A wealth of genotype-specific proteoforms fine-tunes hemoglobin scavenging by haptoglobin." Proceedings of the National Academy of Sciences 117, no. 27 (June 19, 2020): 15554–64. http://dx.doi.org/10.1073/pnas.2002483117.
Повний текст джерелаДисертації з теми "Proteolytic assemblies"
Wickström, Claes. "MUC5B from the oral cavity identification of 'insoluble' assemblies and putative regulatory proteolytic events /." [Malmö] : Faculty of Odontology, Malmö University, 2002. http://catalog.hathitrust.org/api/volumes/oclc/51310732.html.
Повний текст джерелаAppolaire, Alexandre. "Etude des grands assemblages protéolytiques de la famille TET : processus d'oligomérisation et régulation fonctionnelle associée." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV062/document.
Повний текст джерелаProteolysis is a key function in the cell for the maintenance of the proteome integrity, the metabolism and for the regulation of many physiological processes. The thesis work is focused on a family of self-compartmentalized energy-independent cytosolic peptidases discovered in Archaea, the TET aminopeptidases. Three different TET showing contrasted enzymatic specificities co-exist in the cytosol of the hyperthermophilic archaeon Pyrococcus horikoshii, which is the model organism for this study. The structural characterization of the known members of this family shows that they self-assemble in a unique 450 kDa hollow tetrahedral structure . Recent studies have revealed the existence of peptidases complexes that adopt the same conformation in the three domains of life. The first part of this work allowed identifying structural markers to assign without any ambiguity uncharacterized peptidases to the TET family. The second objective of the work was to understand the multiplicity of TET peptidases in hyperthermophilic archaeon that was highlighted by a phylogenomic study presented in this work . The co-expression of PhTET2 and PhTET3 in E. coli revealed that the two proteins form a hetero-oligomeric complex with enhanced enzymatic activity compared to the homo-oligomers. The last part of the work addressed the question of oligomerization-function relationship in TET particles. A mutagenesis strategy was used to slow down the oligomerization process of PhTET2, and, using an integrative strategy combining biochemistry, enzymology, biophysics (SAXS and AUC) and in vivo studies we were able to dissect the oligomerization pathway of the TET particles and to demonstrate that it is a highly controlled process aim to enhance the activity of the peptidases. Finally, the contrast variation technique in small angle neutron scattering studies (SANS) allowed us to unravel the rational topology of the TET hetero-oligomers that favored the formation of multi-catalytic enzymatic pockets in the complex. All theses studies contributed to specify the biological importance of the TET molecular machines in the cells
Lee, Kyujin C. "Self-assembled lipopeptide prodrug depot for sustaned [sic] release : design and synthesis of peptide glutamic acid dialkylamides, their self-assembly into tubules, and their stability to proteolytic degradation /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/9276.
Повний текст джерелаBasbous, Hind. "Etudes structurales et propriétés enzymatiques de deux nouvelles aminopeptidases TETs auto-compartimentées chez les archées." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV016/document.
Повний текст джерелаAminopeptidases represent a group of enzymes displaying key cellular function inphysiological and pathological mechanisms. They are involved in the enzymatic cascade beyond the action of endoproteases, in homeostasis through the renewal of the amino acid pool, in the energy metabolism, in the regulation of bioactive peptide activities, in the antigen presentation and in a diversity of pathological mechanisms such as neurological diseases as well as viral and parasitic infections. Aminopeptidases TET are able of forming tetrahedral macro-assemblies built by twelve subunits. In order to better understand their biological function and their mode of action, we studied the functional and structural properties of two novel TET complexes derived from hyperthermophilic archaea. The hyperthermophilic archaeon Methanocaldococcus jannaschii has only one version of TET (MjTET) that was produced in Escherichia coli and purified as dodecameric macromolecule. The search for its enzymatic activity and peptide substrates by using chromogenic/fluorogenic assays and reverse phase HPLC studies, demonstrated that this enzyme is a cobalt-activated leucine aminopeptidase, discriminated from other M42 aminopeptidases by its very broad activity spectrum, that extends to aromatic residues. Complete structure of this aminopeptidase was determined by combining X-ray crystallography (2.4 Å) and cryo-electron microscopy (4.1 Å). Analysis of MjTET specificity pocket indicated possible molecular bases for substrate discrimination in TET peptidases. In depth investigation of the particle internal structure allowed to propose a novel peptide trafficking mechanism for the TET family tetrahedral particles. Three types of TET complexes are present in the hyperthermophilic archaea, Pyrococcus horikoshii. The study of an unassigned protein displaying ~20% identity with the PhTETs systems allowed us to identify a fourth version of TET complex in this organism: PhTET4. The recombinant protein was purified. It formed tetrahedral dodecameric complex. Biochemical studies indicated that the enzyme has a very narrow hydrolytic specificity directed exclusively toward the peptide N-terminal glycine residues. In addition, this enzyme is activated by nickel ions. These features allowed proposing that, in archaea, the multiplicity of specialized TET systems could be associated with heterotrophy while unique TET system displaying “housekeeping” function is present in autotrophic organisms
Mahieu, Emilie. "Étude du mécanisme d’action du protéasome PAN-20S par diffusion de neutrons aux petits angles résolue en temps." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAY073.
Повний текст джерелаProteasomes are large ubiquitous macromolecular assemblies composed of a 20S catalytic complex and a regulatory particle containing an AAA-ATPase module. This cellular machine is responsible for selectively degradation of intracellular proteins in order to allow proteome renewal, elimination of defective proteins and control of many biological functions. The objective of this thesis was to reveal the mechanisms by which the AAA-ATPase complexes selectively unfold substrate proteins and translocate them into the 20S particle, where they are destroyed. To this end, an innovative approach was used by combining time-resolved small-angle neutron scattering (TR-SANS) combined with fluorescence spectroscopy to monitor biochemical activity. The proteasome of the hyperthermophilic archaea Methanocaldococcus jannaschii was used as a model system. It is composed of the 20S protease of the regulatory particle AAA-ATPase PAN. A variant of the fluorescent protein GFP was used as a substrate protein.The data obtained show that PAN unfolding activity generates denatured species of GFP forming aggregates. The association with the 20S particle prevents the formation of these species and indicates that once the unfolding of a substrate by PAN is engaged, translocation into the 20S complex and degradation processes are closely coupled. Analysis of the neutron scattering spectra of the GFP substrate reveal that the native GFP population is rapidly disappearing in favor of peptides generated by the 20S protease, as confirmed by mass spectrometric analysis. This demonstrates the highly processive nature of the proteasome. Finally, two modes of action of PAN have been identified depending on the amount of proteins to be degraded compared to the PAN-20S proteasome. This work allows to experimentally validate one of the proteasome function models previously proposed and emphases the importance of controlling the association of proteasomes in vivo. This study also highlights the interest of TR-SANS technique to study the functional dynamics of large cellular machines
Chintamani, Joshi Anuja. "Influence of the substrate specificity of Mycobacterium tuberculosis ClpX on the transcriptional profile." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/5466.
Повний текст джерелаЧастини книг з теми "Proteolytic assemblies"
Shahian, Tina, and Charles S. Craik. "Kaposi's Sarcoma Virus Assemblin (Herpesvirus 8-type Assemblin)." In Handbook of Proteolytic Enzymes, 3545–50. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-382219-2.00784-5.
Повний текст джерелаGibson, Wade. "Cytomegalovirus Assemblin and Precursor." In Handbook of Proteolytic Enzymes, 3540–45. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-382219-2.00783-3.
Повний текст джерелаJupp, Ray, Alison Ritchie, Michael Robinson, Anne Broadhurst, and John Mills. "Epstein-Barr Virus Assemblin." In Handbook of Proteolytic Enzymes, 3552–54. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-382219-2.00786-9.
Повний текст джерелаMcMillan, David, Ray Jupp, John Mills, and John Kay. "Varicella-Zoster Virus Assemblin." In Handbook of Proteolytic Enzymes, 3555–56. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-382219-2.00787-0.
Повний текст джерелаJupp, Ray, John Mills, Natalie J. Tigue, and John Kay. "Human Herpesvirus Type 6 Assemblin." In Handbook of Proteolytic Enzymes, 3550–52. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-382219-2.00785-7.
Повний текст джерелаKihlberg, Jan. "Glycopeptide synthesis." In Fmoc Solid Phase Peptide Synthesis. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637256.003.0012.
Повний текст джерелаТези доповідей конференцій з теми "Proteolytic assemblies"
Medintz, Igor L., Thomas Pons, Kim E. Sapsford, Philip E. Dawson, and Hedi Mattoussi. "Self-assembled quantum dot-bioconjugates: characterization and use for sensing proteolytic activity." In SPIE Defense and Security Symposium, edited by Craig S. Halvorson, Daniel Lehrfeld, and Theodore T. Saito. SPIE, 2008. http://dx.doi.org/10.1117/12.782174.
Повний текст джерелаHurley, Jennifer R., Abdul Q. Sheikh, Meredith Beckenhaupt, Cameron Ingram, Andrew Mutchler, and Daria A. Narmoneva. "Self-Assembling Peptide Nanofibers for MMP Delivery and Cardiac Regeneration in Diabetes." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53761.
Повний текст джерелаVerweij, C. L., M. Hart, and H. Pannekoek. "VON WILLEBRAND FACTOR (vWF) PRO-POLYPEPTIDE IS REQUIRED FOR vWF MULTIMER FORMATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642831.
Повний текст джерелаSadler, J. Evan. "THE MOLECULAR BIOLOGY OF VON WILLEBRAND FACTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643930.
Повний текст джерела