Добірка наукової літератури з теми "Protéine (IPP)"
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Статті в журналах з теми "Protéine (IPP)":
Reboud-Ravaux, Michèle. "Dégradation induite des protéines par des molécules PROTAC et stratégies apparentées : développements à visée thérapeutique." Biologie Aujourd’hui 215, no. 1-2 (2021): 25–43. http://dx.doi.org/10.1051/jbio/2021007.
Bianchi, I., T. Collares, V. F. Campos, P. V. Cavalcanti, C. Kaefer, E. K. Corrêa, O. A. Dellagostin, T. Lucia Jr., J. C. Deschamps, and M. N. Corrêa. "Fator do plasma seminal associado à integridade de membrana de espermatozóides suínos pós-descongelamento." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 60, no. 2 (April 2008): 384–88. http://dx.doi.org/10.1590/s0102-09352008000200017.
Guérin, Eva, Mélina Meunier, and Stéphanie Plenchette. "IAP et cancer : le NO contre-attaque." médecine/sciences 37, no. 6-7 (June 2021): 681–83. http://dx.doi.org/10.1051/medsci/2021084.
BERANGER, C. "(only in French) Dossier : Systèmes d’élevage et typicité des produits laitiers." INRAE Productions Animales 16, no. 4 (August 11, 2003): 271–73. http://dx.doi.org/10.20870/productions-animales.2003.16.4.3665.
Doyon, Sabrina. "Mise en marché et certification de l’anguille argentée et de l’esturgeon noir de l’estuaire du St-Laurent: des « vendredis maigres » aux produits fins." Canadian Food Studies / La Revue canadienne des études sur l'alimentation 4, no. 1 (May 26, 2017): 87–107. http://dx.doi.org/10.15353/cfs-rcea.v4i1.190.
Douglas, Nicolás, Pedro Olmedo, Carlos Roberto Douglas, and Osmar Monte. "Influência do hipotireoidismo induzido por propiltiouracil na mucosa gengival do rato." Arquivos Brasileiros de Endocrinologia & Metabologia 50, no. 5 (October 2006): 926–29. http://dx.doi.org/10.1590/s0004-27302006000500015.
FALANGA, Junior MATONDO, Beni BOSINGA NSELE, SUKUMI KUSONGA, Shekinah MBUYI, Daddie DUABA, and Patience NGELINKOTO MPIA. "Etude De Dosage Des Eléments Minéraux Dans Quelques Espèces Des Chenilles Comestibles Consommées A Kinshasa." International Journal of Progressive Sciences and Technologies 41, no. 1 (October 22, 2023): 106. http://dx.doi.org/10.52155/ijpsat.v41.1.5608.
FARRANT, Laura, Marie-Pierre LABAU, Martine PADILLA, Chloé DENEUFBOURG, Laurence FORTUN-LAMOTHE, Sophie PENAVAYRE, and Antoine BESNIER. "Évaluation de la durabilité de la filière Indication Géographique Protégée « Canard à foie gras du Sud-Ouest »." INRA Productions Animales 31, no. 2 (October 25, 2018): 131–44. http://dx.doi.org/10.20870/productions-animales.2018.31.2.2319.
Symoneaux, R., D. Ugalde, and F. Jourjon. "Analysis of the perceptions of wine consumers toward environmental approaches: Support for the management of environmental strategy." BIO Web of Conferences 15 (2019): 03020. http://dx.doi.org/10.1051/bioconf/20191503020.
MEWOLI, BEKONO E. M., YIMTA W. FOUTSE, F. NGUEGUIM, J.-P. DJIENTCHEU, F. NGUIMATSIA, and T. DIMO. "Effets de l’extrait aqueux des feuilles de Solanum torvum sw (solanaceae) sur quelques altérations des fonctions hépatique et rénale induite par la gentamicine." Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB) 2, no. 3 (December 20, 2023). http://dx.doi.org/10.57220/jatpb.v2i3.115.
Дисертації з теми "Protéine (IPP)":
Alleman, Cécile. "Accès synthétique au châssis [5-8-5] de la fusicoccine-A pour la synthèse d’analogues simplifiés en vue d'étudier les interactions protéine-protéine." Electronic Thesis or Diss., Université de Rennes (2023-....), 2023. http://www.theses.fr/2023URENS090.
In biological media, protein-protein interactions (PPI) are of huge importance, as they allow the regulation of many cellular events. PPI classically involve two partners: an adapter protein and its effector protein(s) regulated either in a positive or a negative manner. Inhibition of PPI has thus been considered as a solid therapeutic approach. On the other hand, stabilization of PPI remains scarcely investigated, but may lead to new promising approaches. This project focuses on the 14-3-3 family adapter protein which interacts with more than 200 protein partners. Among them, p53 protein is subjected to a lot of studies as this tumor suppressor protein regulates multiple biological processes (DNA repair, apoptosis). However, those major functions appear to be silenced in most cancer cases, thus allowing tumor cells proliferation. Some studies have shown that stabilization of the 14-3-3/p53 pair with the help of a molecular glue permitted to restore tumor suppressor activity of p53. Among the examined molecular glues, the fusicoccin-A (FC-A) natural product is shown to lodge in the valley formed by 14-3-3 and increases stabilization of the 14-3-3/p53 interaction. In this context, to enlarge the p53/14-3-3 molecular glue library, this project focuses on the access to simplified FC-A analogs through the synthesis of tricyclic scaffold. [6-8-5] analogs from an aromatic substrate are envisaged, as well as [5-8-5] analogs from a cyclopentane derivative, closer to the target structure. Various strategies have been explored in order to access these analogs
Becker, Emmanuelle. "Prédictions bioinformatiques des propriétés des domaines de reconnaissance peptidique." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2007. http://tel.archives-ouvertes.fr/tel-00553471.
Kuenemann, Mélaine. "Etude de l'espace chimique des modulateurs d'interactions protéine-protéine et leurs applications en chimie biologie." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC215.
Protein-protein interactions (PPI) represent a wealth of potential therapeutic targets. However targeting them with synthetic compounds represent a major challenge. The aim of this thesis was to find a way to overcome these challenges by studying the physicochemical profile of PPI inhibitors (aka chemical space). We firstly manually collected structures, pharmacological and physicochemical profiles of inhibitors of PPI (iPPI) in a database named iPPI-DB. Then, we identified new iPPI properties to favour and that did not preclude further drug development. Indeed, 4 descriptors were found specific to iPPI and that do not rely on the hydrophobicity and on the size. They represent either the 3D shape of the compounds or the distribution of their hydrophobic/hydrophilic interacting regions. This opens new ways to design and select iPPI. In a second analysis, we further validated these properties on larger datasets and address the disparity between PPI families. We could demonstrate that comparable classes of PPI targets can identified using separately their target- or their ligand-space. This analysis may help to prioritize the desired physicochemical properties of iPPI using class-specific profiles. Finally, using a combination virtual screening and cell viability assay, we were able to identify 6 compounds that inhibit the interaction between TRAIL and DR5 implied in HIV (human immunodeficiency virus)
Chamoun, Jean. "Contribution du couplage CE-ICP/MS dans l'étude des interactions métals-protéine non-covalentes." Université Louis Pasteur (Strasbourg) (1971-2008), 2005. http://www.theses.fr/2005STR13090.
The screening of metal/protein interactions using CE coupled to ICP/MS was investigated. The development of this new analytical tool requires, besides the hyphenation of the two techniques, both an efficient separation of the proteins and a sensitive detection of metals. The optimization of the electrophoretic separation of a protein-test mixture led to the use of a borate buffer, pH 9. 2, which both minimizes adsorption and allows the separation of all proteins’ mixture with a good migration times reproducibility. The hyphenation between capillary electrophoresis and ICP/MS was performed using a sheath flow interface. The optimization of parameters, such as coolant, auxiliary and nebulizer gases, composition and flowrate of the sheath flow solution and position of the capillary in the nebulizer was carried out in order to obtain the best detection sensitivity and separation efficiency. However, this type of interface involves important samples dilutions, which led us to develop an on-line preconcentration technique in order to improve the detection limits. The detection limits calculated for the copper and zinc contained in the carbonic anhydrase, the less efficiently concentrated protein, showed an improvement of the detection limits in CE-ICP/MS of 6 times for copper and 5 times for zinc. CE-ICP/MS was then used in the study of the interactions of three transition metals (Cd, Co and Ni) with a mixture of proteins made of metalloproteins and major blood serum proteins. These studies revealed a similar behavior of cobalt and nickel, completely different from that of cadmium. In the case of the metalloproteins, hyphenated CE-ICP/MS allowed to identify the probable nature of the interaction sites. Moreover, this method allowed studies on the relative affinity of various metals with a mixture of proteins. The dissociative aspect of the separation was also exploited in order to obtain kinetic data which allowed the access to the dissociation constants of the complexes and in certain cases, highlighted the presence of multiple interaction sites. Finally, the technique was applied to so-called “hard cations”: lanthanides and uranyl ion (UO22+). The first results showed a massive adsorption of these cations on the capillaries surface. Nevertheless, the studies, carried out on a mixture of six proteins, previously identified as uranium-targets, showed that four of them interact with the uranium, among which albumin and transferrin
Vijayakumar, Jeshlee Cyril. "Rôle du domaine de type prion de Imp dans la régulation des granules RNP neuronaux." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4099.
Eukaryotic mRNAs are bound by RNA Binding Proteins (RBP) and packaged into diverse range of macromolecular assemblies named RNP granules. In neurons, transport RNP granules are implicated in the transport of specific mRNAs to axons or dendrites, and in their local translation in response to external cues. Although little is known about the assembly and regulation of these granules in vivo, growing evidence indicates that the presence of Prion Like domains (PLD) within RBPs favours multivalent protein–protein and protein-RNA interactions, promoting the transition of soluble complexes into RNP granules. The conserved RBP Imp is as a core component of RNP granules that are actively transported to axons upon neuronal remodelling in Drosophila. Furthermore, Imp function was shown to be required for axonal remodelling during Drosophila nervous system maturation. Analyses of the domain architecture of the Imp protein revealed that, in addition to four RNA binding domains (RBD), Imp contains a Cterminal domain showing a striking enrichment in Glutamines and Serines, which is one of the characteristics of a PLD. During my PhD, I explored the function of the PLD in the context of granule assembly and transport. In cultured cells, I observed that Imp granules assembled in the absence of the PLD, however their number and size were increased. Proteins with scrambled PLD sequence accumulated in granules of normal size and number, implying that the degree of disorder of this domain, and not its sequence, is essential for granule homeostasis. Moreover, FRAP experiments, performed on cultured cells and in vivo, revealed that Imp PLD is important to maintain the turnover of these granules. In vivo, this domain is both necessary and sufficient for efficient transport of Imp granules to axons. These defects are associated with a reduction on the number of motile granules in axons. Furthermore, mutant forms lacking the PLD do not rescue the axon remodelling defects observed upon imp loss of function. Finally, a swapping experiment in which I moved Imp PLD from the C-terminus to the N-terminus of the protein revealed that the functions of Imp PLD in granule transport and homeostasis are uncoupled, and that PLD-dependent modulation of Imp granule properties is dispensable in vivo. Together, my results show that Imp PLD of is not required for the assembly of RNP granules, but rather regulates granule number and dynamics. Furthermore, my work uncovered an unexpected in vivo function for a PLD in axonal transport and remodelling during nervous system maturation
Vijayakumar, Jeshlee Cyril. "Rôle du domaine de type prion de Imp dans la régulation des granules RNP neuronaux." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4099/document.
Eukaryotic mRNAs are bound by RNA Binding Proteins (RBP) and packaged into diverse range of macromolecular assemblies named RNP granules. In neurons, transport RNP granules are implicated in the transport of specific mRNAs to axons or dendrites, and in their local translation in response to external cues. Although little is known about the assembly and regulation of these granules in vivo, growing evidence indicates that the presence of Prion Like domains (PLD) within RBPs favours multivalent protein–protein and protein-RNA interactions, promoting the transition of soluble complexes into RNP granules. The conserved RBP Imp is as a core component of RNP granules that are actively transported to axons upon neuronal remodelling in Drosophila. Furthermore, Imp function was shown to be required for axonal remodelling during Drosophila nervous system maturation. Analyses of the domain architecture of the Imp protein revealed that, in addition to four RNA binding domains (RBD), Imp contains a Cterminal domain showing a striking enrichment in Glutamines and Serines, which is one of the characteristics of a PLD. During my PhD, I explored the function of the PLD in the context of granule assembly and transport. In cultured cells, I observed that Imp granules assembled in the absence of the PLD, however their number and size were increased. Proteins with scrambled PLD sequence accumulated in granules of normal size and number, implying that the degree of disorder of this domain, and not its sequence, is essential for granule homeostasis. Moreover, FRAP experiments, performed on cultured cells and in vivo, revealed that Imp PLD is important to maintain the turnover of these granules. In vivo, this domain is both necessary and sufficient for efficient transport of Imp granules to axons. These defects are associated with a reduction on the number of motile granules in axons. Furthermore, mutant forms lacking the PLD do not rescue the axon remodelling defects observed upon imp loss of function. Finally, a swapping experiment in which I moved Imp PLD from the C-terminus to the N-terminus of the protein revealed that the functions of Imp PLD in granule transport and homeostasis are uncoupled, and that PLD-dependent modulation of Imp granule properties is dispensable in vivo. Together, my results show that Imp PLD of is not required for the assembly of RNP granules, but rather regulates granule number and dynamics. Furthermore, my work uncovered an unexpected in vivo function for a PLD in axonal transport and remodelling during nervous system maturation
Pinet, Louise. "Structural and functional investigation of the C-terminal intrinsically disordered fragment of ErbB2." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS375/document.
ErbB2/HER2 is a receptor tyrosine kinase of the EGFR (ErbB1) family overexpressed in 20% of breast cancers and associated to a particularly aggressive form of the disease. ErbB receptors are only active upon dimerization that enables phosphorylation of their C-terminal tail by their tyrosine kinase domain. Phosphorylation then triggers interaction with adaptor proteins and activation of signaling pathways, mainly Ras/MAPK and Akt/PI3K. Those pathways control cell proliferation, motility and resistance to apoptosis. Contrary to ErbB1/3/4, ErbB2 can dimerize without any ligand. Understanding other mechanisms of regulation of its tyrosine phosphorylation and of its interactions is thus particularly interesting.ErbB2 structure and function have been extensively studied. This has led to the development of several FDA-approved targeted drugs, that are effective but to which resistance occurs, amongst which the Trastuzumab antibody that targets ErbB2 extracellular domain. The C-terminal tail of ErbB2 (CtErbB2) has been widely ignored in these studies. Since it is intrinsically disordered, the concepts and tools to study it have only emerged in the last few years.In the present work, I have performed the structural and dynamic study of CtErbB2. I showed that despite its lack of any stable structure, this proline-rich region exhibits several transient secondary structures and a long-range contact that might participate in the regulation of its intra- and inter-molecular interactions. Then, I characterized the adaptor protein Grb2, which is a partner of ErbB2 that is essential for the activation of the MAPK pathway. The solution organization of the domains of this modular protein in its apo-form was unknown so far. I also studied the interaction between Grb2 and CtErbB2, showing that in addition to the known SH2-phosphotyrosine interaction, a polyproline motif of CtErbB2 binds to the N-terminal SH3 domain of Grb2. Finally, I implemented several strategies to phosphorylate CtErbB2 tyrosines, to study more extensively the effect of phosphorylation on the whole tail
Boudoukha, Selim. "Étude de la régulation post-transcriptionnelle de l’expression des gènes par la protéine de liaison à l’ARN IMP-2 au cours de la myogenèse." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T095/document.
The RNA-binding proteins IMPs (IGF-II mRNA binding protein) first discovered in rhabdomyosarcoma cells (RMS) are expressed during embryonic development but their expression is decreased in adult tissues.We showed that IMPs and particularly IMP-2 are strongly expressed in mouse myoblatsts, during early regeneration of skeletal muscle in vivo and in and RMS. IMP-2 loss of function experiments using siRNA have shown that IMP-2 is necessary for microtubules stability(MTs), cell motility and invasion of myoblasts and RMS.Expression of IMP-2 specifically increases MTs stability by an enrichment of detyrosinated tubulin Glu-tubulin. Detyrosination is indispensable for myogenic differentiation and plays substantial role in tumor growth. Additionaly, MTs stabilization play an important role in focal adhesion remodeling, in cytoskeleton integrity, cell adhesion and cell motility.To get new insight into molecular mechanism underlying the function of IMP-2 in MTs stability and cell motility, full ranscriptome analysis was performed between IMP-2 knockdown (KD) myoblasts and control myoblatsts. We have further shown that IMP-2 controls the mRNA levels of many important mediators of cell adhesion such as PINCH-2, as well as multiple cytoskeleton remodeling, such as MuRF-3.We have identified a number of functionally relevant protein partners of IMP-2.Moreover subsequent RNAi screens have revealed the importance of IMP-2 regulated transcripts involved in cell motility and cell adhesion In conclusion, we show that IMP-2 dependent regulation of mRNA such as MuRF3 and PINCH2 largely contributes to the motility –deficient in IMP-2 KD cells. Moreover these results indicate clearly, that further analysis of IMP2 protein partners and RNA targets regulated by IMP-2 will help to characterized the function of IMP-2 and to propose a model of IMP-2 transcriptional regulation of gene expression in myoblasts and RMS cells
Bonneau, Benjamin. "Implication des protéines de la famille Bcl-2 dans la régulation des flux calciques au cours du développement embryonnaire précoce du poisson zèbre." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10155/document.
Apoptosis is a key cellular process for tissue homeostasis. Apoptotic cell death is under control of Bcl-2 family proteins which regulate outer mitochondrial membrane permeability. However, beyond their role in apoptosis, Bcl-2 family proteins are also involved in other cellular processes such as cell cycle or metabolism. In our laboratory we are interested in non-apoptotic functions of Bcl-2 family proteins in embryonic development. Using zebrafish model we have shown that Bcl-2 proteins control different processes during early development thanks to their ability to regulate calcium homeostasis. Indeed, we have shown that the anti-apoptotic protein Nrz participates in actin cytoskeleton remodeling during epiboly by regulating cytosolic calcium concentration via an interaction with the IP3 receptor (IP3R). We have also demonstrated that Nrz decreases calcium release from the endoplasmic reticulum by inhibiting IP3 fixation on its receptor. We have furthermore identified a new pro-apoptotic member of Bcl-2 family, Bcl-wav which is expressed only in fish and frogs. This protein regulates mitochondrial calcium homeostasis by interacting with VDAC. We have moreover shown that this activity is essential for convergence and extension movements during early zebrafish development
Chevreux, Sylviane. "Spéciation directe de métalloprotéines séparées sur gels d'électrophorèse : analyses XAS de la superoxyde dismutase et ICP-MS de protéines arseniées." Thesis, Bordeaux 1, 2009. http://www.theses.fr/2009BOR13880/document.
Metalloproteomic is a new discipline which ally proteome determination and the identification, location and speciation of inorganic elements bound to proteins. The low concentration of these heteroelements and sometimes their non-covalent binding to proteins need to set up analytical tools enabling the protein separation at high resolution, without any modification of the bond protein-heteroelement, and the protein speciation with a technique presenting a low detection limit. The aim of this study is to set up such protocols on two proteic systems, depicting the two main protein-heteroelement interactions: forming of metallic complexes or covalent bonds. First, we studied copper, zinc superoxide dismutase (CuZnSOD), mutants of this protein being involved in a neurodegenerative disease, the amyotrophic lateral sclerosis. Isoelectric point isoforms of wild-type and mutant CuZnSOD, separated on electrophoresis gel, were analyzed using X-ray Absorption Spectroscopy (XAS). XAS experiments on proteins separated on electrophoresis gel were performed for the first time. Data analysis at Zn K-edge demonstrated the feasibility of this technique and the ones at the Cu K-edge highlighted oxidation states Cu(I) et Cu(II) differences between isoforms. Second, we studied arsenic metabolisation to understand its carcinogenicity. Proteins extracted from hepatic cells exposed to arsenic were separated using gel electrophoresis and liquid chromatography. Samples analysis using mass spectrometry highlighted three proteic species which bind arsenic