Дисертації з теми "Protein-water systems"
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Ознайомтеся з топ-18 дисертацій для дослідження на тему "Protein-water systems".
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Pence, David N. "Protein partitioning in two-phase liquid-liquid acetonitrile-water systems." Ohio : Ohio University, 1996. http://www.ohiolink.edu/etd/view.cgi?ohiou1178047340.
Повний текст джерелаKonidala, Praveen. "Molecular dynamics simulations of glycolipid and carbohydrate binding protein systems in the explicit water environment." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=979967791.
Повний текст джерелаAjaj, Yathrib [Verfasser], Hermann [Gutachter] Weingärtner, and Christian [Gutachter] Herrmann. "Dynamics and thermodynamics of protein folding and interactions in water-cosolvent systems / Yathrib Ajaj ; Gutachter: Hermann Weingärtner, Christian Herrmann." Bochum : Ruhr-Universität Bochum, 2012. http://d-nb.info/1131354575/34.
Повний текст джерелаGlättli, Alice [Verfasser]. "Computer simulation of biomolecular systems: From the formulation of models for water, to the interpretation of experiment, to the investigation of polypeptide folding and membrane protein dynamics / Alice Glättli." Aachen : Shaker, 2004. http://d-nb.info/1172613141/34.
Повний текст джерелаOgden, Leanne Gaye. "Interfacial studies of oil-water systems containing fat crystals." Thesis, Oxford Brookes University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283814.
Повний текст джерелаSalehi, Sayed Mohammad. "Engineering Cell-free Protein Synthesis Technology for Codon Reassignment, Biotherapeutics Production using Just-add-Water System, and Biosensing Endocrine Disrupting Compounds." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6711.
Повний текст джерелаGeorge, Mary. "Urea and Non-Protein Nitrogen Metabolism in Infants : With Special Reference to the Sudden Infant Death Syndrome (SIDS)." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5141-1/.
Повний текст джерелаPANZICA, Massimo. "Protein-Sugar-Water Systems Far From Thermodynamic Ideality." Doctoral thesis, 2012. http://hdl.handle.net/10447/94736.
Повний текст джерелаMondal, Sayantan. "Theoretical studies of chemical dynamics in complex systems: Nanoconfined water, microdroplets, biomolecular hydration layer, and water-mediated protein association." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/4898.
Повний текст джерелаConstantinescu, Aruxandei Diana [Verfasser]. "Patterns of protein stability and interactions in water-cosolvent systems / vorgelegt von Diana Constantinescu Aruxandei." 2010. http://d-nb.info/1007596546/34.
Повний текст джерелаMahadevaswamy, M. "Production of blue green alga spirulina platensis for biomass protein in clean water and integrated systems." Thesis, 1994. http://hdl.handle.net/2009/2989.
Повний текст джерелаLambeth, Bradley. "Towards Adaptive Resolution Modeling of Biomolecular Systems in their Environment." Thesis, 2012. http://hdl.handle.net/1911/64645.
Повний текст джерелаKonidala, Praveen [Verfasser]. "Molecular dynamics simulations of glycolipid and carbohydrate binding protein systems in the explicit water environment / von Praveen Konidala." 2006. http://d-nb.info/979967791/34.
Повний текст джерелаMukherjee, Saumyak. "Structure, Thermodynamics and Dynamics in Complex Systems: From Stability of Biomolecules to Phase Transitions in Polymorphic Ice." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/4870.
Повний текст джерелаINSPIRE Fellowship, DST, India
Hazra, Milan K. "From collective relaxation phenomena to phase separation in binary mixtures and some contributions to the hydration dynamics in the vicinity of biologically active molecules." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/5261.
Повний текст джерелаLee, Hsin-Chieh, and 李欣潔. "To investigate the application of water-in-oil-in-water emulsion for the protein drugs in oral delivery system." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/78157341505319499048.
Повний текст джерела國立宜蘭大學
生物技術研究所碩士班
97
Since the injection administration as the peptides and proteins delivery system, it imposes discomfort and inconvenience on patients, particularly for a long-term treatment. Therefore, the goal of this thesis is to find out an oral delivery system for improving the absorption of therapeutic protein drugs. Emulsion is one of strategies known delivery vehicles for those oral medicines. Water-in-oil -in-water (W/O/W) multiple emulsion has been known to be possible to protect protein drugs from enzyme degradation and enhance the absorption of hydrophilic drugs to systemic circulation. Therefore, we tried to use granulocyte colony-stimulating factor (G-CSF) as the indicator to test the emulsion formulation for the oral delivery system in the study. In this two-step emulsification procedure, the data of the droplet size (2 μm of diameter), encapsulation efficiency (40±5%), stability (at pH 1.2 for 2 hrs and 60°C for 5 days), permeability (into Caco-2 cell monolayer with 30 min) and in vitro cytotoxicity studies all showed that the emulsion formulation was indicated to promote the absorption of proteins drugs by oral administration. Thus, we used the E. coli expression system to express and purify the recombinant human G-CSF (rhG-CSF). And then, rhG-CSF was incorporated into the inner aqueous phase of the emulsion for the test of oral bioavailability. After 6 hrs of oral administration of various dosages of rhG-CSF in solution or in emulsion for 7 days, the proliferations of leukocytes in the two treatments with the highest dose of rhG-CSF (2,500 μg/kg/day) were significantly higher than the blank emulsion (p < 0.01). However, two of them, rhG-CSF in emulsion and not in emulsion, were not different. After 12 hrs of oral administration, mice, administrated by 50, 500, and 2500 μg/kg/day rhG-CSF emulsion, all presented a significant elevation in leukocyte numbers when compared to the blank emulsion (p < 0.01). Finally, it was indicated about the advantages of the W/O/W multiple emulsions with encapsulation efficiency, penetrating ability, and stability to resist acid pH (1.2) and high temperature (60°C). In the future, it could be potential for protein drugs delivery by oral administration.
Selimovic, Seila. "Microfluidics for protein crystallization and mapping phase diagrams of aqueous solutions /." 2010.
Знайти повний текст джерелаShih, Po-hung, and 施柏宏. "The Application of Phase Separation for the Acetonitrile-Water System with addition of Salts in Protein Purification." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/92254102940057182475.
Повний текст джерела東海大學
化學工程學系
92
Because of its extremely powerful resolution, reverse phase high pressure liquid chromatography (RP-HPLC) has been widely employed in the preparative- and large-scale of separation and purification for enormous proteins, peptides, and amino acids. But its application is hindered by the involvement of high concentration of organic solvents that might affect the protein stability and activity. Acetonitrile (ACN)-water system is the most commonly used mobile phase in RP-HPLC. Normally, proteins are eluted from RP-HPLC columns with relatively high concentrations of ACN(>60%v/v), in which have to be removed by either buffer exchange or lyophilization in the following stages. For the chemical safety considerations and their influences on the separation membrane, chromatography resins, and vacuum evaporator system during lyophilization, people are sometimes hesitatied to apply the RP-HPLC technique in their purification processes. It has been demonstrated that the phase separation occurring under sub-zero temperature could remove the majority ACN. However, the sub-zero operation temperature may provoke sample freeze and the severe temperature shift will affect the protein properties. In this study, we combined the salt addition and cooling procedures to improve the efficiency at the above-zero temperature. We found that by the addition of property salts, such as potassium phosphate buffer (pH=7.0), phase separation of ACN-water could come about effectively at 4℃, whereas the protein purification process are normally carried out. We investigated the percentage of ACN removal and the recovery of protein from the ACN solution by altering the concentrations of salt, initial ACN, as well as sample protein, respectively. We also examined the effects of the proteins natures, such as proteins with different hydrophobicity, on the protein distribution between the ACN-rich phase and the water-rich phase. With an optimized condition for this salt-induced phase separation, our results demonstrated that phase separation efficiency of ACN-water system by the addition of small amount of proper salts(such as potassium phosphate buffer, pH=7.0 ) at 4℃could achieve the similar efficiency as that previously described by cooling to a sub-zero temperature. Meanwhile, the greater than 50% of ACN could be simply removed, while more than 90% of protein could be easily recovered. Therefore, the modified phase separation technique by coupling cooling and salt addition procedure offers us the more economic, more effective, and more reliable approach to achieve the buffer exchange, removing at concentrating protein extent for proteins, as well as maintaining protein stability and activity in general protein purification processes.