Статті в журналах з теми "Protein targeted lead molecule"
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Hyun, Soonsil, and Dongyun Shin. "Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases." Life 11, no. 7 (June 24, 2021): 607. http://dx.doi.org/10.3390/life11070607.
Повний текст джерелаGiardina, Sarah F., Elena Valdambrini, Michael Peel, Manny D. Bacolod, Mace L. Rothenberg, Richard B. Lanman, J. David Warren, and Francis Barany. "Cure-PROs: Next-generation targeted protein degraders." Journal of Clinical Oncology 41, no. 16_suppl (June 1, 2023): e15101-e15101. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e15101.
Повний текст джерелаMusielak, Bogdan, Weronika Janczyk, Ismael Rodriguez, Jacek Plewka, Dominik Sala, Katarzyna Magiera-Mularz, and Tad Holak. "Competition NMR for Detection of Hit/Lead Inhibitors of Protein–Protein Interactions." Molecules 25, no. 13 (July 1, 2020): 3017. http://dx.doi.org/10.3390/molecules25133017.
Повний текст джерелаThomas, Bedwyr ab Ion, H. Lois Lewis, D. Heulyn Jones, and Simon E. Ward. "Central Nervous System Targeted Protein Degraders." Biomolecules 13, no. 8 (July 25, 2023): 1164. http://dx.doi.org/10.3390/biom13081164.
Повний текст джерелаDas, Debanu, Matthew Duncton, Patricia Pellicena, Ashley Deacon, David Wilson, and Millie Georgiadis. "Development of a DNA damage response (DDR) therapeutics platform for oncology." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e15036-e15036. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15036.
Повний текст джерелаMilosevic, Ivana. "Resistance to targeted therapy in chronic lymphocytic leukemia." Medical review 75, Suppl. 1 (2022): 57–61. http://dx.doi.org/10.2298/mpns22s1057m.
Повний текст джерелаQokoyi, Ndibonani Kebonang, Priscilla Masamba, and Abidemi Paul Kappo. "Proteins as Targets in Anti-Schistosomal Drug Discovery and Vaccine Development." Vaccines 9, no. 7 (July 8, 2021): 762. http://dx.doi.org/10.3390/vaccines9070762.
Повний текст джерелаOlsen, Sarah Naomi, Laura Godfrey, James P. Healy, Charles Hatton, and Scott A. Armstrong. "Abstract 681: Targeted MLL-AF9 degradation is phenocopied by combined DOT1L and Menin inhibition." Cancer Research 82, no. 12_Supplement (June 15, 2022): 681. http://dx.doi.org/10.1158/1538-7445.am2022-681.
Повний текст джерелаKhattri, Ram B., Daniel L. Morris, Stephanie M. Bilinovich, Erendra Manandhar, Kahlilah R. Napper, Jacob W. Sweet, David A. Modarelli, and Thomas C. Leeper. "Identifying Ortholog Selective Fragment Molecules for Bacterial Glutaredoxins by NMR and Affinity Enhancement by Modification with an Acrylamide Warhead." Molecules 25, no. 1 (December 30, 2019): 147. http://dx.doi.org/10.3390/molecules25010147.
Повний текст джерелаYang, Kylie, Jacek L. Kolanowski, and Elizabeth J. New. "Mitochondrially targeted fluorescent redox sensors." Interface Focus 7, no. 2 (April 6, 2017): 20160105. http://dx.doi.org/10.1098/rsfs.2016.0105.
Повний текст джерелаLi, Yan, Yi Jia, Xiao-Lin Wang, Hai Shang, and Yu Tian. "Protein-Targeted Degradation Agents Based on Natural Products." Pharmaceuticals 16, no. 1 (December 28, 2022): 46. http://dx.doi.org/10.3390/ph16010046.
Повний текст джерелаRayevsky, O. V., O. M. Demchyk, P. A. Karpov, S. P. Ozheredov, S. I. Spivak, A. I. Yemets та Ya B. Blume. "Structure-based virtual screening for new lead compounds targeted Plasmodium α-tubulin". Faktori eksperimental'noi evolucii organizmiv 28 (31 серпня 2021): 135–39. http://dx.doi.org/10.7124/feeo.v28.1389.
Повний текст джерелаRoos, Martina M., Michelle Li, Pang Amara, and John P. Chute. "Pharmacologic Targeting of LIN28/Let-7 in Acute Myeloid Leukemia." Blood 132, Supplement 1 (November 29, 2018): 4072. http://dx.doi.org/10.1182/blood-2018-99-119982.
Повний текст джерелаAngelbello, Alicia J., Suzanne G. Rzuczek, Kendra K. Mckee, Jonathan L. Chen, Hailey Olafson, Michael D. Cameron, Walter N. Moss, Eric T. Wang, and Matthew D. Disney. "Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model." Proceedings of the National Academy of Sciences 116, no. 16 (March 29, 2019): 7799–804. http://dx.doi.org/10.1073/pnas.1901484116.
Повний текст джерелаSchäfer, Mirijam, Marie Luise Semmler, Thoralf Bernhardt, Tobias Fischer, Vinodh Kakkassery, Robert Ramer, Martin Hein, et al. "Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins." Cancers 13, no. 8 (April 7, 2021): 1770. http://dx.doi.org/10.3390/cancers13081770.
Повний текст джерелаShen, Jingshi, Eric Davis, and Charles Dinarello. "Haploid genetic dissection of immune molecule trafficking (TECH1P.836)." Journal of Immunology 192, no. 1_Supplement (May 1, 2014): 69.4. http://dx.doi.org/10.4049/jimmunol.192.supp.69.4.
Повний текст джерелаChen, Jianlin, Xiaorong Liu, and Jianhan Chen. "Targeting Intrinsically Disordered Proteins through Dynamic Interactions." Biomolecules 10, no. 5 (May 11, 2020): 743. http://dx.doi.org/10.3390/biom10050743.
Повний текст джерелаYin, Xiaoyan, Subha Subramanian, Shih-Jen Hwang, Christopher J. O’Donnell, Caroline S. Fox, Paul Courchesne, Pieter Muntendam, et al. "Protein Biomarkers of New-Onset Cardiovascular Disease." Arteriosclerosis, Thrombosis, and Vascular Biology 34, no. 4 (April 2014): 939–45. http://dx.doi.org/10.1161/atvbaha.113.302918.
Повний текст джерелаBeaton, Nigel, Roland Bruderer, Yuehan Feng, Jagat Adhikari, Ivan Cornella-Taracido, and Lukas Reiter. "Abstract 2024: High resolution limited proteolysis (HR-LiP), a novel structural proteomics approach for the prediction of small molecule-protein binding events." Cancer Research 83, no. 7_Supplement (April 4, 2023): 2024. http://dx.doi.org/10.1158/1538-7445.am2023-2024.
Повний текст джерелаAjay, Amrendra K., Philip Chu, Poojan Patel, Christa Deban, Chitran Roychowdhury, Radhika Heda, Ahmad Halawi, et al. "High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma." Pharmaceutics 15, no. 4 (April 18, 2023): 1274. http://dx.doi.org/10.3390/pharmaceutics15041274.
Повний текст джерелаKanakaveti, V., P. Anoosha, R. Sakthivel, S. K. Rayala, and M. M. Gromiha. "Influence of Amino Acid Mutations and Small Molecules on Targeted Inhibition of Proteins Involved in Cancer." Current Topics in Medicinal Chemistry 19, no. 6 (May 2, 2019): 457–66. http://dx.doi.org/10.2174/1568026619666190304143354.
Повний текст джерелаSanthaKumari, Subha Lakshmi Gopalakrishnan Nair, and Samuel GnanaPrakash Vincent. "Identification and molecular characterization of drug targets of methicillin resistant Staphylococcus aureus." Journal of Applied and Natural Science 14, no. 4 (December 19, 2022): 1152–57. http://dx.doi.org/10.31018/jans.v14i4.3693.
Повний текст джерелаHanajima-Ozawa, Miyuki, Takeshi Matsuzawa, Aya Fukui, Shigeki Kamitani, Hiroe Ohnishi, Akio Abe, Yasuhiko Horiguchi, and Masami Miyake. "Enteropathogenic Escherichia coli, Shigella flexneri, and Listeria monocytogenes Recruit a Junctional Protein, Zonula Occludens-1, to Actin Tails and Pedestals." Infection and Immunity 75, no. 2 (November 21, 2006): 565–73. http://dx.doi.org/10.1128/iai.01479-06.
Повний текст джерелаSalha M Tawati, Aisha A Alsfouk, and Asma Alsarrah. "Homology modelling and molecular docking study of TMPRSS2 with small-molecule protease inhibitors to control SARS-CoV-2." International Journal of Research in Pharmaceutical Sciences 13, no. 2 (April 19, 2022): 201–10. http://dx.doi.org/10.26452/ijrps.v13i2.190.
Повний текст джерелаBonilla, Francisco A. "Personalized therapy for common variable immunodeficiency." Allergy and Asthma Proceedings 41, no. 1 (January 1, 2020): 19–25. http://dx.doi.org/10.2500/aap.2020.41.190012.
Повний текст джерелаFricke, Doerte Raphaela, Gang Liu, Hyejin Kim, Pingyuan Wang, Xi Liu, Haiying Chen, Ruixia Ma, Junhai Xu, Jia Zhou, and Qiang Shen. "Abstract 3940: Novel Bax activators for targeted breast cancer therapy." Cancer Research 82, no. 12_Supplement (June 15, 2022): 3940. http://dx.doi.org/10.1158/1538-7445.am2022-3940.
Повний текст джерелаSavva, Loukiani, and Savvas N. Georgiades. "Recent Developments in Small-Molecule Ligands of Medicinal Relevance for Harnessing the Anticancer Potential of G-Quadruplexes." Molecules 26, no. 4 (February 5, 2021): 841. http://dx.doi.org/10.3390/molecules26040841.
Повний текст джерелаSmith, Kathryn, Andrea Lopez-Arroyo, Jason Berk, Peter Hegan, Peter Nower, Samantha Tice, Aurelie Moutran, et al. "Abstract PR09: KRAS-targeted PROTAC degraders are broadly efficacious against KRAS-dependent tumor models." Molecular Cancer Research 21, no. 5_Supplement (May 1, 2023): PR09. http://dx.doi.org/10.1158/1557-3125.ras23-pr09.
Повний текст джерелаSimard, Jeffrey R., Linda Lee, Ellen Vieux, Reina Improgo, Trang Tieu, Andrew J. Phillips, Stewart L. Fisher, Roy M. Pollock, and Eunice Park. "High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics." SLAS DISCOVERY: Advancing the Science of Drug Discovery 26, no. 4 (January 11, 2021): 503–17. http://dx.doi.org/10.1177/2472555220985049.
Повний текст джерелаShuttleworth, Stephen, Richard Connors, Jiasheng Fu, Jinqian Liu, Mike Lizarzaburu, Wei Qiu, Rajiv Sharma, Malgorzata Wanska, and Alex Zhang. "Design and Synthesis of Protein Superfamily-Targeted Chemical Libraries for Lead Identification and Optimization." Current Medicinal Chemistry 12, no. 11 (June 1, 2005): 1239–81. http://dx.doi.org/10.2174/0929867054020936.
Повний текст джерелаYunes, Sarah A., Jennifer L. S. Willoughby, Julian H. Kwan, Jessica M. Biagi, Niranjana Pokharel, Hang Gyeong Chin, Emily A. York, et al. "Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins." PLOS ONE 17, no. 6 (June 15, 2022): e0268857. http://dx.doi.org/10.1371/journal.pone.0268857.
Повний текст джерелаKeefe, Anthony D., Jeremy S. Disch, Jennifer Duffy, Esther C. Lee, Diana Gikunju, Betty Chan, Benjamin D. Levin, et al. "Abstract 5346: Discovery of new targeted protein degraders using DNA-encoded chemistry." Cancer Research 83, no. 7_Supplement (April 4, 2023): 5346. http://dx.doi.org/10.1158/1538-7445.am2023-5346.
Повний текст джерелаOgino, Fedorov, Adams, Okada, Ito, Sugiyama, and Ogino. "Vesiculopolins, a New Class of Anti-Vesiculoviral Compounds, Inhibit Transcription Initiation of Vesiculoviruses." Viruses 11, no. 9 (September 14, 2019): 856. http://dx.doi.org/10.3390/v11090856.
Повний текст джерелаKelleher, Joseph, Laurent Audoly, Veronica Campbell, Jesse Chen, Nan Ji, Hari Kamadurai, Henry Li, et al. "Targeted Degradation of IRAK4 Protein Via Heterobifunctional Small Molecules for Treatment of MYD88 Mutant Lymphoma." Blood 132, Supplement 1 (November 29, 2018): 2953. http://dx.doi.org/10.1182/blood-2018-99-120148.
Повний текст джерелаDa Silva, Gustavo F., Alex Ghetu, Leandro Cerchietti, Jose M. Polo, Andrew Coop, Alexander Mackerell, Gilbert G. Prive, and Ari Melnick. "Design and Development of Small Molecules for Specific Targeted Therapy of Diffuse Large B-Cell Lymphoma." Blood 110, no. 11 (November 16, 2007): 799. http://dx.doi.org/10.1182/blood.v110.11.799.799.
Повний текст джерелаD’Annessa, Ilda, Naama Hurwitz, Valentina Pirota, Giovanni Luca Beretta, Stella Tinelli, Mark Woodford, Mauro Freccero, et al. "Design of Disruptors of the Hsp90–Cdc37 Interface." Molecules 25, no. 2 (January 15, 2020): 360. http://dx.doi.org/10.3390/molecules25020360.
Повний текст джерелаPattenden, Samantha G., Jeremy M. Simon, Aminah Wali, Chatura N. Jayakody, Jacob Troutman, Andrew W. McFadden, Joshua Wooten, et al. "High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility." Proceedings of the National Academy of Sciences 113, no. 11 (February 29, 2016): 3018–23. http://dx.doi.org/10.1073/pnas.1521827113.
Повний текст джерелаRanganathan, Santhalakshmi, Alexander Kornienko, Antonio Evidente, Daniel Romo, and Joseph Taube. "Abstract 6153: Triple negative breast cancer targeted by Ophiobolin A: Epithelial-mesenchymal transition take the lead." Cancer Research 83, no. 7_Supplement (April 4, 2023): 6153. http://dx.doi.org/10.1158/1538-7445.am2023-6153.
Повний текст джерелаKelly, Aileen, Daniel W. Robbins, May Tan, Austin Tenn-McClellan, Joel McIntosh, Jeffrey Wu, Zef Konst, et al. "Targeted Protein Degradation of BTK As a Unique Therapeutic Approach for B Cell Malignancies." Blood 134, Supplement_1 (November 13, 2019): 3805. http://dx.doi.org/10.1182/blood-2019-129262.
Повний текст джерелаKuroki, K., R. Russnak, and D. Ganem. "Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum." Molecular and Cellular Biology 9, no. 10 (October 1989): 4459–66. http://dx.doi.org/10.1128/mcb.9.10.4459-4466.1989.
Повний текст джерелаYosaatmadja, Yuliana, Adam Vorn Patterson, Jeff Bruce Smaill, and Christopher John Squire. "The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition." Acta Crystallographica Section D Biological Crystallography 71, no. 3 (February 26, 2015): 525–33. http://dx.doi.org/10.1107/s1399004714027539.
Повний текст джерелаKuroki, K., R. Russnak, and D. Ganem. "Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum." Molecular and Cellular Biology 9, no. 10 (October 1989): 4459–66. http://dx.doi.org/10.1128/mcb.9.10.4459.
Повний текст джерелаXia, Yuxing, Grace M. Lloyd та Benoit I. Giasson. "Targeted proteolytic products of τ and α-synuclein in neurodegeneration". Essays in Biochemistry 65, № 7 (грудень 2021): 905–12. http://dx.doi.org/10.1042/ebc20210028.
Повний текст джерелаFranco, Rafael, Vicent Casadó, Antoni Cortés, Carla Ferrada, Josefa Mallol, Amina Woods, Carme Lluis, Enric I. Canela, and Sergi Ferré. "Basic Concepts in G-Protein-Coupled Receptor Homo- and Heterodimerization." Scientific World JOURNAL 7 (2007): 48–57. http://dx.doi.org/10.1100/tsw.2007.197.
Повний текст джерелаStrasser, Jane E., Monica Arribas, Anastasia D. Blagoveshchenskaya, and Daniel F. Cutler. "Secretagogue-triggered Transfer of Membrane Proteins from Neuroendocrine Secretory Granules to Synaptic-like Microvesicles." Molecular Biology of the Cell 10, no. 8 (August 1999): 2619–30. http://dx.doi.org/10.1091/mbc.10.8.2619.
Повний текст джерелаKarwasra, Ritu, Shaban Ahmad, Nagmi Bano, Sahar Qazi, Khalid Raza, Surender Singh, and Saurabh Varma. "Macrophage-Targeted Punicalagin Nanoengineering to Alleviate Methotrexate-Induced Neutropenia: A Molecular Docking, DFT, and MD Simulation Analysis." Molecules 27, no. 18 (September 16, 2022): 6034. http://dx.doi.org/10.3390/molecules27186034.
Повний текст джерелаRampogu, Shailima, and Mary Rampogu Lemuel. "Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism." BioMed Research International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6068437.
Повний текст джерелаZhou, Dan, Yuan Liu, Josephine Ye, Weiwen Ying, Dinesh Chimmanamada, Luisa Shin Ogawa, Takayo Inoue, Patricia Rao, and Yumiko Wada. "Potent anti-inflammatory activity of a novel of class Hsp90 inhibitors for multiple sclerosis (51.1)." Journal of Immunology 188, no. 1_Supplement (May 1, 2012): 51.1. http://dx.doi.org/10.4049/jimmunol.188.supp.51.1.
Повний текст джерелаBonami, Rachel, Lindsay Nyhoff, Chrys Hulbert, Jamie Felton, Peggy L. Kendall, and James W. Thomas. "One size doesn’t fit all: SLAM-Associated Protein is dispensable for type 1 diabetes but required for autoantibody-mediated arthritis." Journal of Immunology 202, no. 1_Supplement (May 1, 2019): 115.14. http://dx.doi.org/10.4049/jimmunol.202.supp.115.14.
Повний текст джерелаZuo, Jun, Steve Kye, Kevin K. Quinn, Paige Cooper, Robert Damoiseaux, and Paul Krogstad. "Discovery of Structurally Diverse Small-Molecule Compounds with Broad Antiviral Activity against Enteroviruses." Antimicrobial Agents and Chemotherapy 60, no. 3 (December 28, 2015): 1615–26. http://dx.doi.org/10.1128/aac.02646-15.
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