Дисертації з теми "Protein based delivery systems"
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Squire, Marie A. "Protein-based drug delivery systems." Thesis, University of Canterbury. Chemistry, 2004. http://hdl.handle.net/10092/6518.
Повний текст джерелаJørgensen, Lene. "Lipid based drug delivery systems for parenteral delivery of proteins /." Cph. : Department of Pharmaceutics, the Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/lenejoergensen.htm.
Повний текст джерелаKonovalova, M. V., D. S. Khramova, A. V. Ilyina, and D. V. Kurek. "Polysaccharides Based Nanoparticles as Protein Oral Delivery System." Thesis, Sumy State University, 2013. http://essuir.sumdu.edu.ua/handle/123456789/35483.
Повний текст джерелаSchwab, Martin. "Degradation of lipid based drug delivery systems and characterization of semi-synthetic spider silk proteins for the application in pharmaceutical technology." Diss., Ludwig-Maximilians-Universität München, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-165238.
Повний текст джерелаSchwab, Martin [Verfasser], and Gerhard [Akademischer Betreuer] Winter. "Degradation of lipid based drug delivery systems and characterization of semi-synthetic spider silk proteins for the application in pharmaceutical technology / Martin Schwab. Betreuer: Gerhard Winter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1046785257/34.
Повний текст джерела游, 晧欣. "Development of novel systems promoting intracellular protein delivery." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/157905.
Повний текст джерелаHeffernan, Michael John. "Biodegradable polymeric delivery systems for protein subunit vaccines." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24787.
Повний текст джерелаCommittee Chair: Dr. Niren Murthy; Committee Member: Dr. Carson Meredith; Committee Member: Dr. Julia Babensee; Committee Member: Dr. Mark Prausnitz; Committee Member: Dr. Ravi Bellamkonda.
Pape, Valerie Elizabeth. "Methotrexate-protein conjugates as soluble drug delivery systems." Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277877.
Повний текст джерелаLiu, Weipeng. "Biopolymer-based ocular drug delivery systems." Diss., Connect to online resource - MSU authorized users, 2008.
Знайти повний текст джерелаEstey, Tia Brie. "Protein instability associated with PLGA delivery systems and UV-induced protein oxidation /." Connect to full text via ProQuest. IP filtered, 2006.
Знайти повний текст джерелаTypescript. Includes bibliographical references (leaves 144-161). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
Tantipolphan, Ruedeeporn, and n/a. "Characterisation of protein-phospholipid interactions in implantable delivery systems." University of Otago. School of Pharmacy, 2007. http://adt.otago.ac.nz./public/adt-NZDU20071218.162425.
Повний текст джерелаMok, Kenneth W. C. "Characterization of lipid-based DNA delivery systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34590.pdf.
Повний текст джерелаSenderoff, Richard I. "Development of fibrin-based drug delivery systems /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487677267728699.
Повний текст джерелаMawad, Damia Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Development of Novel hydrogels for protein drug delivery." Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/25221.
Повний текст джерелаWebster, Alexandra Margaret. "Design, synthesis and delivery of peptide-based systems." Thesis, Durham University, 2018. http://etheses.dur.ac.uk/12616/.
Повний текст джерелаMackenzie, R. C. "Computational modelling of polymer-based drug delivery systems." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/28852/.
Повний текст джерелаPeagram, Rebecca Elizabeth. "Emulsion formulations as delivery systems for soluble protein subunit viral vaccines." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363615.
Повний текст джерелаFach, Lars Matthias [Verfasser]. "Protein-based nanoparticles for drug delivery applications / Lars Matthias Fach." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/116056146X/34.
Повний текст джерелаSteiert, Elena [Verfasser]. "Dynamic Protein-based Nanoparticles for Drug Delivery Applications / Elena Steiert." Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1205821899/34.
Повний текст джерелаDeng, Ni. "A secure, payment-based email delivery system." CSUSB ScholarWorks, 2005. https://scholarworks.lib.csusb.edu/etd-project/2909.
Повний текст джерелаSharma, Divya. "Drug Delivery Systems for Treatment of Diabetes Mellitus." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/31745.
Повний текст джерелаNational Institutes of Health (NIH) grant R15GM114701
ND EPSCoR seed award FAR0030636
Oh, Sejin. "Development of mucus permeating nanoparticles-based drug delivery systems." Doctoral thesis, Universitat Ramon Llull, 2016. http://hdl.handle.net/10803/382626.
Повний текст джерелаExiste un interés creciente, tanto en el mundo académico como en la investigación industrial en el desarrollo de sistemas de liberación de fármacos macromoleculares (proteínas, péptidos, oligonucleótidos) capaces de atravesar la mucosa. En este sentido, la utilización de vectores sintéticos para la liberación de dichas macromoléculas, permite disponer de una plataforma versátil y altamente eficiente. Sin embargo, la capa de mucosa con propiedades adhesivas y altamente viscoelástica, tiene una elevada capacidad de atrapar y eliminar cualquier sustancia extraña que quede adherida sobre su superficie, limitando, de forma evidente, la eficacia de cualquier tratamiento Esta Tesis se centra en el desarrollo de sistemas de liberación de ADN, diseñados a medida, que presentan una elevada estabilidad y eficacia de transfección con un nivel muy bajo de toxicidad y muy importante en el contexto de la tesis, una capacidad de permeación a través de la mucosa. Además la tesis también se centra en el diseño y el desarrollo de métodos y técnicas in vitro que ayuden a una mejor selección de sistemas eficientes de liberación a través de la mucosa. Así se ha desarrollado un método simple y eficiente, basado en la utilización de una microbalanza de cuarzo con disipación (QCM-D). Este método ha permitido evaluar la interacción de polímeros y nanopartículas con una capa de mucina. Los resultados obtenidos con el método desarrollado han permitido diseñar sistemas de nanopartículas con un mayor potencial de permeación a través de la mucosa. Esta técnica de alta sensibilidad también ha ofrecido la posibilidad de evaluar las dos propiedades opuestas, el conocimiento de las cuales es necesario para un correcto diseño de sistemas cpaços de cruzar la mucosa: mucoadhesió vs mucopenetració. Los Poly (β-amino ester)s (PBAEs) se han propuesto como sistemas biodegradables capaces de formar nanopartículas, por complejación con ADN, que presentan una elevada capacidad de transfección. Sin embargo, muestran problemas de estabilidad en condiciones fisiológicas y son incapaces de atravesar la capa de mucosa. En esta tesis se describe una nueva solución en la preparación de las formulaciones de los nanocomplejos basada en la utilización de recubrimientos que estabilizan las nanopartículas y aumentan su permeabilidad. Los recubrimeintos propuestos inclutyen: i) azúcares (sucrosa, trhalosa y manitol), ii) quitosano sin modificar de 22 KDa y con 60-120 kDa, iii) quitosano modificado con ácido tioglicólico y iv) ácido poliacrílico-bromelaina. Todas las nuevas formulaciones se han evaluado con diferentes cantidades de recubrimiento. Se han determinado sus propiedades fisicoquímicas y su eficacia de transfección y citotoxicidad frente a células COS-7. Se ha estudiado La difusión de las partículas a través de la mucosa gástrica de cerdo utilizando diferentes técnicas como el tubo rotatorio de silicona o el múltiple particle tracking (MPT). Los resultados obtenidos han mostrado superior estabilidad, eficacia de transfección y permeabilidad sobre la mucosa de las nuevas formulaciones diseñadas.
Mucus penetrating nanoparticle-based delivery systems of macromolecular drugs are currently receiving increasing attention in both academic and industrial research. Synthetic delivery systems provide highly suitable and tunable platform for the delivery of the macromolecules. However, a highly viscoelastic and adhesive mucus layer generally traps and rapidly removes most foreign substance from the mucosal surfaces, thereby limiting effectiveness of these nanocarriers. This Thesis is addressed to the development of engineering DNA delivery systems capable of high stability and transfection efficiency with low toxicity, and quickly crossing the mucus layer. Moreover, this Thesis is focused on design and development of methods and techniques in vitro in order to select more efficient delivery systems. A simple and efficient method, based on the use of the quartz crystal microbalance with dissipation (QCM-D) technique, is developed and evaluated the interaction of the polymers and nanoparticles with the mucin layer, resulting in the development of nanoparticle-based delivery systems to mucosal tissue. This highly sensitive technique also offers to evaluate the two opposing properties, needed for the design of efficient mucous permeation systems: mucoadhesion vs mucus penetration. Poly(β-amino ester)s (PBAEs) are currently considered of great interest as biodegradable polymeric carriers of DNA delivery, but they present limited stability in physiological conditions and the inability to penetrate the mucus layer. In this Thesis, we describe a novel surface-modified formulation of DNA delivery systems consisting of PBAE/DNA complexes and the coating agents, including: i) sugars (sucrose, trehalose or mannitol), ii) unmodified chitosan with a 22 kDa (CS) and a with a 60-120 kDa (CSM), iii) chitosan-thioglycolic acid (CS-TGA), and iv) poly(acrylic acid)-bromelain (PAA-BRO) conjugates. All novel formulations formed with different amounts of the coating agents are evaluated the physicochemical properties. The influence of coating agents on transfection efficiency and cytotoxicity is evaluated in COS-7 cells. Particle diffusion through porcine intestinal mucus (PImucus) is assessed by either rotating silicone tube technique or multiple particle tracking (MPT). The results highlight the superior stability, transfection efficiency and mucus permeability of the novel nanoparticle-based drug delivery systems. The effect of the amount of coating agents is also discussed.
Dua, Pinky. "Model based and parametric control for drug delivery systems." Thesis, Imperial College London, 2005. http://hdl.handle.net/10044/1/8040.
Повний текст джерелаDixon, John Robert. "Examining the impacts of Web-based education delivery systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58335.pdf.
Повний текст джерелаSchultze, Jennifer [Verfasser]. "Polymer-Based Systems for Drug Delivery Studies / Jennifer Schultze." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1186179627/34.
Повний текст джерелаElahrash, K. S. "Some physical studies with polymer based drug delivery systems." Thesis, University of Brighton, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354875.
Повний текст джерелаMohd, Azmi Mohd Azraie Bin. "Integrated silicon nanowire biosensor and MEMS based delivery systems." Thesis, Swansea University, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678641.
Повний текст джерелаAbodinar, Atiga Emhemed. "Construction of potential drug delivery systems based on polysaccharides." Thesis, University of Huddersfield, 2016. http://eprints.hud.ac.uk/id/eprint/32608/.
Повний текст джерелаTang, Qiong. "Multifunctional Natural Material-based Delivery Systems for Gene Therapy." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1415382826.
Повний текст джерелаBrinkmann, Joscha [Verfasser]. "Thermodynamics of Lipid-Based Drug Delivery Systems / Joscha Brinkmann." München : Verlag Dr. Hut, 2021. http://d-nb.info/1238423043/34.
Повний текст джерелаHwang, Jason Jayjoon. "Hyaluronic acid hydrogel microspheres for delivery of protein therapeutics /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7983.
Повний текст джерелаSoane, Robert J. "Bioadhesive polymers as intranasal drug delivery systems for peptide and protein drugs." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298078.
Повний текст джерелаMadeira, do Ó. João. "Applications of glycopolymer libraries as protein aggregation modulators and drug delivery systems." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38014/.
Повний текст джерелаVeldhoen, Marc. "Modifying T cell differentiation via protein based delivery of signalling attenuators." Thesis, Open University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273353.
Повний текст джерелаAyensu, Isaac. "Development of novel formulations for mucosal delivery of protein based drugs." Thesis, University of Greenwich, 2012. http://gala.gre.ac.uk/9807/.
Повний текст джерелаBooth, Ronald L. "An Information Systems Project Delivery Methodology for Implementing Web-Based Program Management Systems." NSUWorks, 2003. http://nsuworks.nova.edu/gscis_etd/420.
Повний текст джерелаStasko, Nathan Allan Schoenfisch Mark H. "Synthesis and characterization of dendrimer-based nitric oxide delivery systems." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1421.
Повний текст джерелаTitle from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.
Mistry, Ajay Ramanlal. "Development of non-viral gene delivery systems based on HMG1." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368705.
Повний текст джерелаBergin, Paul Michael. "Approaches to functionalised amine-based ligands for radiopharmaceutical delivery systems." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409852.
Повний текст джерелаIemsam-Arng, J. "Poly(ethylene) glycol based delivery systems for nucleic acid therapies." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1381001/.
Повний текст джерелаCulcuoglu, Mustafa U. "Reengineering Community Based Chronic Care Delivery Systems: Theory and Applications." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1627573050496332.
Повний текст джерелаOladiran, Gbolahan S. "Development and formulation of wax-based transdermal drug delivery systems." Thesis, Aston University, 2008. http://publications.aston.ac.uk/11060/.
Повний текст джерелаInaba, Hiroshi. "Structural design of cell-penetrating protein needles toward development of intracellular delivery systems." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/195979.
Повний текст джерелаOlszewska, Wieslawa. "The immunogenicity of vaccine delivery systems incorporating epitopes from measles virus fusion protein." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251659.
Повний текст джерелаNolan, Christine Marie. "Microgel Based Materials for Controlled Macromolecule Delivery." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6874.
Повний текст джерелаScally, David James. "Novel polyethylene glycol based drug delivery systems : a calorimetric and QASAR based study." Thesis, University of Kent, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282425.
Повний текст джерелаWong, Ling Wai. "Molecular delivery system based on the nanoporous zeolite microstructures /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BIEN%202006%20WONG.
Повний текст джерелаWang, Nick X. "Controlled Delivery of Protein Therapeutics for HIV Prevention." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1327614039.
Повний текст джерелаPan, Xiaogang. "Design and evaluation of lipid based delivery systems for delivery of small molecules and macro-molecular nucleotides based therapeutic agents." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164679618.
Повний текст джерелаSankaranarayanan, Thampi Sajeesh. "Development of advanced drug delivery systems based on polymethacrylic acid nano/microparticles for oral insulin delivery." Paris 11, 2010. http://www.theses.fr/2010PA114805.
Повний текст джерелаThe work carried out in this thesis was aimed to develop polymer micro- and nanoparticles for the oral administration of insulin. A method of radical polymerization was optimized to design micro and nanoparticles with a hydrogel forming polymer, poly(methacrylic acid) (PMAA). The particles were further modified by the grafting of cystein residues in order to introduce thiol functions which are believed to reinforce mucoadhesive and permeation enhancing properties of the formulation. The particles showed interesting loading properties for insulin and the release of the hormone was found to be pH dependent. Although insulin was mainly retained by the hydrogel particle in releasing medium mimicking the gastric environment, the hormone was released in conditions found in the intestine. The formulated systems have shown to improve the absorption of insulin through the intestinal mucosa in in vitro models including Caco 2 cell monolayers and the Ussing chambers. The microparticles selected from the in vitro experiments for in vivo studies have shown a capacity to deliver active insulin through the oral route to diabetic rats producing a reduction of the glycemia. Tests performed with modified insulin have allowed to identify that among the two strategies followed, this consisting on the association of insulin with a cyclodextrin was the most promising while the one based on the formation of an insulin-PEG conjugate did not brought any benefice