Статті в журналах: "Prostate-related symptoms and signs"

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Castells, Mariana, and K. Frank Austen. "Mastocytosis: Mediator-Related Signs and Symptoms." International Archives of Allergy and Immunology 127, no. 2 (2002): 147–52. http://dx.doi.org/10.1159/000048188.

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Shkodkin, S. V., M. V. Pokrovskiy, S. S. Krasnyak, A. V. Polishchuk, S. V. Chirkov, O. V. Churikova, and N. A. Kravtsova. "Combination therapy for benign prostate hyperplasia-related urinary symptoms." Vestnik Urologii 10, no. 1 (March 30, 2022): 84–95. http://dx.doi.org/10.21886/2308-6424-2022-10-1-84-95.

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Introduction. Non-neurogenic lower urinary tract symptoms (LUTS) are a serious polyetiologic problem in the male population. The side effects of the medication agents used to treat LUTS significantly reduce treatment compliance. According to the literature data, the frequency of refusal for the proposed treatment during the year varies from 20 to 80%. Several studies have shown the benefits of herbal medicine for LUTS concerning the fewer side effects and increased adherence to treatment. However, to obtain a high-level recommendation base, clinical trials are required.Purpose of the study. To evaluate the effectiveness of Gardaprost® in LUTS combination therapy.Materials and methods. The study included 57 men aged 60 – 70 years with diagnosed medium- or large-volume benign prostatic hyperplasia (BPH) and moderate-to-severe LUTS according to I-PSS, morphologically excluded prostate cancer, without urinary infection signs. The patients were randomized into two follow-up groups. Tamsulosin 0.4 mg q.d. was prescribed to patients in the control group. Patients of the main group received Gardaprost® 0.4 mg q.d. in addition to Tamsulosin. The follow-up period in both groups was one-year. The statistical analysis includes data from 56 men. To evaluate therapy at the screening visit and on days 180 and 360, I-PSS, urination diary, IIEF-5, urinalysis, prostate-specific antigen, uroflowmetry, ultrasound were analyzed. Paired t-test and one-way ANOVA test were used to determine intergroup differences in normally distributed variables. For variables with a distribution other than normal, Friedman's two-way ANOVA for related samples was used. Events with a probability greater than 95% were considered statistically significant.Results. At the time of inclusion in the study, the groups were comparable concerning the control parameters. In the main group, there was a more pronounced positive dynamics in the I-PSS score, maximum urine flow rate, and post-void residual urine volume, which corresponded to 7.9 ± 2.1 points, 18.0 ± 7.3 ml/sec, 23.6 ± 13.6 ml vs 19.7 ± 7.2 points, 10 ± 3.5 ml/sec, 65.9 ± 33.2 ml in the main and control groups, respectively (p < 0.001). Additionally, in the main observation group, a decrease in prostate volume was recorded by 18.8% (p < 0.001) was recorded.Conclusion. We have obtained encouraging long-term results from the use of Gardaprost® in combination therapy of moderate-to-severe LUTS caused by medium- and large-volume BPH.

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Issah, Fati, Johanna E. Maree, and Prudence P. Mwinituo. "Expressions of cervical cancer-related signs and symptoms." European Journal of Oncology Nursing 15, no. 1 (February 2011): 67–72. http://dx.doi.org/10.1016/j.ejon.2010.06.003.

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Brett, Benjamin L., Andrew W. Kuhn, Aaron M. Yengo-Kahn, Aaron S. Jeckell, Gary S. Solomon, and Scott L. Zuckerman. "On-Field Signs Predict Future Acute Symptoms After Sport-Related Concussion: A Structural Equation Modeling Study." Journal of the International Neuropsychological Society 24, no. 5 (January 8, 2018): 476–85. http://dx.doi.org/10.1017/s1355617717001321.

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AbstractObjectives:This study investigated the relationship between on-field, objective signs immediately following sport-related concussion and self-reported symptom endorsement within 1 day post injury.Methods:A retrospective case series of 237 concussed high school athletes was performed. On-field signs were evaluated immediately post injury. Self-reported symptoms (2 clusters) were collected within 1 day post injury. A two-step structural equation model and follow-up bivariate regression analyses of significant on-field signs and symptom clusters were performed.Results: Signs of immediate memory, β=0.20,p=.04, and postural instability, β=0.19,p< .01, significantly predicted a greater likelihood of endorsing the cognitive-migraine-fatigue symptom cluster within 1 day post injury. Regarding signs correlated with specific symptoms, immediate memory was associated with symptoms of trouble remembering, χ2=37.92,p< .001, odds ratio (OR)=3.89 (95% confidence interval (CI) [2.47, 6.13]), and concentration difficulties, χ2=10.84,p=.001, OR=2.13 (95% CI [1.37, 3.30]). Postural instability was associated with symptom endorsement of trouble remembering, χ2=12.08,p< .001, OR=1.76 (95% CI [1.29, 2.40]).Conclusions:Certain post-concussion on-field signs exhibited after injury were associated with specific symptom endorsement within 1 day post injury. Based on these associations, individualized education-based interventions and academic accommodations may help reduce unanticipated worry from parents, students, and teachers following a student-athlete’s sport-related concussion, especially in cases of delayed onset symptoms. (JINS, 2018,24, 476–485)

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Biswas, PK, M. Haque, ABMG Robbani, and MM Khan. "Tuberculosis of Prostate." TAJ: Journal of Teachers Association 23, no. 1 (June 1, 2010): 95–97. http://dx.doi.org/10.3329/taj.v23i1.41147.

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We are reporting a case of prostatic tuberculosis in a 50 year old man. The patient was treated due to intense lower urinary tract symptoms caused by benign prostatic hyperplasia. Based on physical examination and accessory investigations the patient was qualified for prostatectomy. Histological analysis of the removed adenoma revealed benign hyperplasia and tuberculosis of the prostate. Retrospectively, no signs of tuberculosis in the lungs or urinary system were confirmed. Antituberculous treatment was immediately administered according to the schedule for the systemic tuberculosis and the patient was followed up. There were no signs of tuberculosis after two months follow-up. TAJ 2010; 23(1): 95-97

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Wallace, Jessica, Tracey Covassin, and Erica Beidler. "Sex Differences in High School Athletes' Knowledge of Sport-Related Concussion Symptoms and Reporting Behaviors." Journal of Athletic Training 52, no. 7 (July 1, 2017): 682–88. http://dx.doi.org/10.4085/1062-6050-52.3.06.

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Context: Recent researchers have reported that athletes' knowledge of sport-related concussion (SRC) has increased but that athletes still lack knowledge of all the signs and symptoms of SRC. Understanding the signs and symptoms of SRC and the dangers of playing while symptomatic are critical to reporting behaviors in high school athletes. Objective: To examine sex differences in knowledge of SRC symptoms and reasons for not reporting a suspected SRC to an authoritative figure in high school athletes. Design: Cross-sectional study. Setting: Survey. Patients or Other Participants: A total of 288 athletes across 7 sports (198 males [68.8%] and 90 females [31.2%]). Main Outcome Measure(s): A validated knowledge-of-SRC survey consisted of demographic questions, a list of 21 signs and symptoms of SRC, and reasons why athletes would not report their SRC. The independent variable was sex. Athlete knowledge of SRC symptoms was assessed by having participants identify the signs and symptoms of SRC from a list of 21 symptoms. Knowledge scores were calculated by summing the number of correct answers; scores ranged from 0 to 21, with a score closer to 21 representing greater knowledge. Reporting-behavior questions asked athletes to choose reasons why they decided not to report any possible SRC signs and symptoms to an authoritative figure. Results: A sex difference in total SRC symptom knowledge was found (F286 = 4.97, P = .03, d = 0.26). Female high school athletes had more total SRC symptom knowledge (mean ± standard deviation = 15.06 ± 2.63; 95% confidence interval = 14.54, 15.57) than males (14.36 ± 2.76; 95% confidence interval = 13.97, 14.74). Chi-square tests identified significant relationships between sex and 8 different reasons for not reporting an SRC. Conclusions: High school males and females had similar SRC symptom knowledge; however, female athletes were more likely to report their concussive symptoms to an authoritative figure.

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Russo, Maria Julieta, Fernando Salvat, Gustavo Sevlever, and Ricardo F. Allegri. "Acute and Subacute Clinical Markers After Sport-Related Concussion." Neurology 98, no. 1 Supplement 1 (December 27, 2021): S16.1—S16. http://dx.doi.org/10.1212/01.wnl.0000801884.93340.fd.

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ObjectiveThis study aimed to determine the association of a range of off-field symptoms reported by athletes retrospectively with on-field concussion signs and in-office symptoms among rugby union players.BackgroundPlayers with sports concussion experience multiple symptoms. Understanding the association between these symptoms and clinical markers of concussion would facilitate a targeted approach to symptom assessment and treatment.Design/MethodsCross-sectional study. We consecutively enrolled 92 adult rugby union players, within the first 72 hours after sport concussion. Ten symptoms assessed using a retrospective symptoms interview were examined for their association with observed concussion signs and post-concussion symptoms using the Post-Concussion Symptoms Scale (PCSS).ResultsOdds ratios revealed that athletes who was overtly symptomatic based on retrospective concussion interview at the time of the concussion were over 2.6 times more likely (p = 0.047) to have exhibited post-traumatic amnesia when compared with athletes who was asymptomatic. There were no differences between groups in terms of on-field loss of consciousness or confusion. Off-field symptoms reported by athlete were associated with symptoms reporting on the Beck Depression Inventory (OR 2.8; 95% CI 1.14–6.88), headache (OR 4.9; 95% CI 1.92–12.79), memory concerns (OR 3.15; 95% CI 1.06–9.34), pressure in head (OR 2.8; 95% CI 1.03–8.08), and visual disturbances (OR 3.9; 95% CI 1.05–14.50) within the first 72 hours after concussion.ConclusionsSymptomatic concussed rugby athletes have increased odds for sustaining on-field concussion signs that can be observed by others and persistent symptoms within the first 72 hours after concussion. Information from the on-field and off-field assessment is essential in understanding the severity of sports concussion.

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Kirakoya, Brahima, Abdoul Karim Pare, Babagana Mustapha Abubakar, and Moussa Kabore. "Prostate Cancer Presenting with Parietal Bone Metastasis." Case Reports in Urology 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/1928570.

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Bone metastases from prostate cancer are very common. They are usually located on the axial skeleton. However, cranial bone metastases especially to the parietal bone are rare. We report a case of metastatic prostate cancer presenting with left parietal bone metastasis in a patient with no urological symptoms or signs. We should consider prostate cancer in any man above 60 years presenting unusual bone lesions.

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Gerhardsson, Lars, Christina Ahlstrand, Per Ersson, Per Jonsson, and Ewa Gustafsson. "Vibration related symptoms and signs in quarry and foundry workers." International Archives of Occupational and Environmental Health 94, no. 5 (February 13, 2021): 1041–48. http://dx.doi.org/10.1007/s00420-021-01660-8.

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Abstract Purpose The development of vascular and neurosensory findings were studied in two groups of long-term exposed quarry and foundry workers with different vibration exposures, working conditions and work tasks. Methods The study included 10 quarry workers (mean age 43 yrs., mean exposure time 16 yrs.) and 15 foundry workers (35 yrs.; 11 yrs.) at two plants in Sweden. All participants completed a basic questionnaire and passed a medical examination including a number of neurosensory tests, e.g. the determination of vibration (VPT) and temperature (TPT) perception thresholds as well as a musculoskeletal examination of the neck, shoulders, arms and hands. Results A high prevalence of neurosensory findings (40%) was found among the quarry workers. Both groups, however, showed a low prevalence of vibration white fingers (VWF). Foundry workers showed significantly better sensitivity than quarry workers for all monofilament tests (p ≤ 0.016), TPT warmth in dig 2 (p = 0.048) and 5 dexter (p = 0.008), and in dig 5 sinister (p = 0.005). They also showed a better VPT performance in dig 5 dexter (p = 0.031). Conclusions Despite high vibration exposure, the prevalence of VWF was low. The high prevalence of neurosensory findings among the quarry workers may depend on higher A(8) vibration exposure and higher exposure to high-frequency vibrations. An age-effect and exposure to cold could also be contributing factors. The nervous system seems to be more susceptible to high-frequency vibrations than the vascular system. For neurosensory injuries, the current ISO 5349-1 standard is not applicable.

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Machado, Alessandra Salles, Paula Midori Castelo, Fernando Capela e Silva, and Elsa Lamy. "Covid-19: Signs and symptoms related to the feeding behavior." Physiology & Behavior 242 (December 2021): 113605. http://dx.doi.org/10.1016/j.physbeh.2021.113605.

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Keay, Lisa, Katie Edwards, and Fiona Stapleton. "Signs, Symptoms, and Comorbidities in Contact Lens-Related Microbial Keratitis." Optometry and Vision Science 86, no. 7 (July 2009): 803–9. http://dx.doi.org/10.1097/opx.0b013e3181ae1b69.

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Shahzad, Iqbal, Muhammad Ali Yousuf, Khadim Hussain, Mumtaz Manzoor, Ghulam Mustafa Pathan, and Tanveer Ahmed. "Prostatic Inflammation's Effects on Individuals with Benign Prostate Hyperplasia's Clinical Consequences." Pakistan Journal of Medical and Health Sciences 16, no. 12 (November 30, 2022): 845–47. http://dx.doi.org/10.53350/pjmhs20221611845.

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Objective: In order to ascertain the impact of silent inflammatory prostatitis on the clinical results of individuals receiving trans urethral prostate resection owing to benign prostatic hyperplasia. Study Design: Retrospective study Place and Duration: This retrospective study was conducted at Liaquat National Hospital Karachi in the period from April, 2022 to September, 2022. Methods: Total 330 patients were presented in this study. In this study, individuals over 45 years without a history of urologic surgery who presented to a urology clinic with lower urinary tract symptoms related to benign prostatic hyperplasia were included. Pathological outcomes and clinical indicators were evaluated before and one year after surgery. Mean Standard deviation was used to present data and categorical variables were assessed by frequencies and percentages. Results: Mean age of the patients was 61.3±10.42 years. Among 330 cases, 200 (60.6%) patients were had benign prostatic hyperplasia and 130 (39.4%) cases had both prostatic inflammation (category-IV) and benign prostatic hyperplasia. Before TURP, mean prostate volume in BP patients was 55.7±8.11 m3 and in BPH/PI patients was 55.3±10.6 m3 and after TURP mean prostate volume in BP patients was 23.2±1.20 m3 and in BPH/PI group 23.4±8.17 m3. We found that people with prostate inflammation had lower Qmax values and a higher preoperative prostate score compared to those who had no signs of inflammation before to prostate transurethral resection. Conclusion: In this study, we came to the conclusion that in individuals with benign prostatic hyperplasia, prostate inflammation without symptoms might worsen lower urinary tract symptoms and the rate of urine flow. Keywords: Benign Prostatic Hyperplasia (BPH), Prostate Pathology, Prostatic Inflammation

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Shahzad, Iqbal, Muhammad Ali Yousuf, Khadim Hussain, Mumtaz Manzoor, Ghulam Mustafa Pathan, and Tanveer Ahmed. "Prostatic Inflammation's Effects on Individuals with Benign Prostate Hyperplasia's Clinical Consequences." Pakistan Journal of Medical and Health Sciences 16, no. 12 (December 31, 2022): 807–9. http://dx.doi.org/10.53350/pjmhs20221612807.

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Objective: In order to ascertain the impact of silent inflammatory prostatitis on the clinical results of individuals receiving trans urethral prostate resection owing to benign prostatic hyperplasia. Study Design: Retrospective study Place and Duration: This retrospective study was conducted at Liaquat National Hospital Karachi in the period from April, 2022 to September, 2022. Methods: Total 330 patients were presented in this study. In this study, individuals over 45 years without a history of urologic surgery who presented to a urology clinic with lower urinary tract symptoms related to benign prostatic hyperplasia were included. Pathological outcomes and clinical indicators were evaluated before and one year after surgery. Mean Standard deviation was used to present data and categorical variables were assessed by frequencies and percentages. Results: Mean age of the patients was 61.3±10.42 years. Among 330 cases, 200 (60.6%) patients were had benign prostatic hyperplasia and 130 (39.4%) cases had both prostatic inflammation (category-IV) and benign prostatic hyperplasia. Before TURP, mean prostate volume in BP patients was 55.7±8.11 m3 and in BPH/PI patients was 55.3±10.6 m3 and after TURP mean prostate volume in BP patients was 23.2±1.20 m3 and in BPH/PI group 23.4±8.17 m3. We found that people with prostate inflammation had lower Qmax values and a higher preoperative prostate score compared to those who had no signs of inflammation before to prostate transurethral resection. Conclusion: In this study, we came to the conclusion that in individuals with benign prostatic hyperplasia, prostate inflammation without symptoms might worsen lower urinary tract symptoms and the rate of urine flow. Keywords: Benign Prostatic Hyperplasia (BPH), Prostate Pathology, Prostatic Inflammation

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Ayaki, Masahiko, Kazuno Negishi, Motoko Kawashima, Miki Uchino, Minako Kaido, and Kazuo Tsubota. "Age Is a Determining Factor of Dry Eye-Related Signs and Symptoms." Diagnostics 10, no. 4 (March 31, 2020): 193. http://dx.doi.org/10.3390/diagnostics10040193.

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Purpose: The reported signs and symptoms of dry eye (DE) have been discordant. This study evaluated risk factors of DE-related symptoms and signs to explore their association with patient demographics, focusing on the age factor. Methods: The study enrolled 704 consecutive patients visiting general eye clinics who complained of ocular discomfort, but had normal vision. The patients were asked about the presence of six common symptoms related to DE and, tear break-up time (TBUT). The severity of patients’ keratopathy was also examined, and patients underwent Schirmer’s test. Results: Logistic regression analysis demonstrated that younger age (≤29 years) was associated with non-visual symptoms and keratopathy, while older age (≥60 years) was associated with short TBUT and low values on Schirmer’s test. Middle age was associated with both severe symptoms and signs. Conclusions: Discrepancies in the signs and symptoms of DE may depend, in part, on age, with younger subjects showing severe non-visual symptoms with apparently normal tear function and severe keratopathy, and older subjects showing fewer symptoms and less severe keratopathy despite worse tear function.

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Cannon, A., and P. Abrams. "Diseases of the prostate." Reviews in Clinical Gerontology 14, no. 2 (May 2004): 119–28. http://dx.doi.org/10.1017/s0959259804001418.

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Benign enlargement of the prostate gland does not always cause symptoms or obstruction to the flow of urine. Old terminology, for example, ‘prostatism’ can therefore be misleading, and the British Association of Urological Surgeons (BAUS), the International consultation on BPH and the International Continence Society accept the definitions given below:Benign prostatic hyperplasia (BPH) is a histological diagnosis. The first pathological signs appear under the age of 40 years, followed by a rapid increase in prevalence with age; 80% of 80-year-olds have evidence of BPH. The onset of BPH is dependent on the presence of functioning testes and increasing age. It is characterized by a combination of atrophy and proliferation in both glandular and stromal tissue. Although BPH is detectable in most elderly men, it does not always cause enlargement of the prostate, symptoms, or obstruction to the flow of urine.

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Roseman, Mark J., Robin L. Chalmers, and Gary R. Cutter. "LENS CARE SYSTEMS, COMPLIANCE, AND CONTACT LENS-RELATED SIGNS AND SYMPTOMS." Optometry and Vision Science 71, Supplement (December 1994): 98. http://dx.doi.org/10.1097/00006324-199412001-00192.

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Williams, Grant, Richard Pazdur, and Robert Temple. "Assessing Tumor-Related Signs and Symptoms to Support Cancer Drug Approval." Journal of Biopharmaceutical Statistics 14, no. 1 (December 24, 2004): 5–21. http://dx.doi.org/10.1081/bip-120028503.

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Biswas, Bikash, Sanjukta Mandal, and Jahir Abbas. "Benign prostatic hyperplasia treated with individualised homoeopathic medicines: An evidence-based case series." Journal of Integrated Standardized Homoeopathy 5 (December 31, 2022): 99–106. http://dx.doi.org/10.25259/jish_42_2021.

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The study aimed to evaluate the effects of homoeopathic treatment in patients with benign prostatic Hypertrophy (BPH). This was an experimental study conducted using the primary data and assessed based on clinical symptoms and pathological reports. A total of three cases were included in this study. BPH was diagnosed based on clinical symptoms and ultrasonography reports. The patients were prescribed Lycopodium clavatum, Thuja occidentalis and Arsenicum album based on clinical signs, the totality of symptoms and individualisation. Dietary changes were recommended as well. Improvement was assessed based on symptom reduction and changes in ultrasonography reports. All three patients improved clinically and pathologically, including a reduction in prostate size. This case series provides evidence that individualised homoeopathic treatment is effective in pathological conditions such as BPH, in both symptom relief and pathological changes.

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Lau, Brian C., Anthony P. Kontos, Michael W. Collins, Anne Mucha, and Mark R. Lovell. "Which On-field Signs/Symptoms Predict Protracted Recovery From Sport-Related Concussion Among High School Football Players?" American Journal of Sports Medicine 39, no. 11 (June 28, 2011): 2311–18. http://dx.doi.org/10.1177/0363546511410655.

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Background: There has been increasing attention and understanding of sport-related concussions. Recent studies show that neurocognitive testing and symptom clusters may predict protracted recovery in concussed athletes. On-field signs and symptoms have not been examined empirically as possible predictors of protracted recovery. Purpose: This study was undertaken to determine which on-field signs and symptoms were predictive of a protracted (≥21 days) versus rapid (≤7 days) recovery after a sports-related concussion. On-field signs and symptoms included confusion, loss of consciousness, posttraumatic amnesia, retrograde amnesia, imbalance, dizziness, visual problems, personality changes, fatigue, sensitivity to light/noise, numbness, and vomiting. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: The sample included 107 male high school football athletes who completed computerized neurocognitive testing within an average 2.4 days after injury, and who were followed until returned to play as determined by neuropsychologists using international clinical concussion management guidelines. Athletes were then grouped into rapid (≤7 days, n = 62) or protracted (≥21 days, n = 36) recovery time groups. The presence of on-field signs and symptoms was determined at the time of injury by trained sports medicine professionals (ie, ATC [certified athletic trainer], team physician). A series of odds ratios with χ2 analyses and subsequent logistic regression were used to determine which on-field signs and symptoms were associated with an increased risk for a protracted recovery. Results: Dizziness at the time of injury was associated with a 6.34 odds ratio (95% confidence interval = 1.34-29.91, χ2 = 5.44, P = .02) of a protracted recovery from concussion. Surprisingly, the remaining on-field signs and symptoms were not associated with an increased risk of protracted recovery in the current study. Conclusion: Assessment of on-field dizziness may help identify high school athletes at risk for a protracted recovery. Such information will improve prognostic information and allow clinicians to manage and treat concussion more effectively in these at-risk athletes.

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Iyer, S. N., L. Boekestyn, C. M. Cassidy, S. King, R. Joober, and A. K. Malla. "Signs and symptoms in the pre-psychotic phase: description and implications for diagnostic trajectories." Psychological Medicine 38, no. 8 (March 26, 2008): 1147–56. http://dx.doi.org/10.1017/s0033291708003152.

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BackgroundFew studies have examined the underlying factor structure of signs and symptoms occurring before the first psychotic episode. Our objective was to determine whether factors derived from early signs and symptoms are differentially associated with non-affective versus affective psychosis.MethodA principal components factor analysis was performed on early signs and symptoms reported by 128 individuals with first-episode psychosis. Factor scores were examined for their associations with duration of untreated illness, drug abuse prior to onset of psychosis, and diagnosis (schizophrenia versus affective psychosis).ResultsOf the 27 early signs and symptoms reported by patients, depression and anxiety were the most frequent. Five factors were identified based on these early signs and symptoms: depression, disorganization/mania, positive symptoms, negative symptoms and social withdrawal. Longer duration of untreated illness was associated with higher levels of depression and social withdrawal. Individuals with a history of drug abuse prior to the onset of psychosis scored higher on pre-psychotic depression and negative symptoms. The two mood-related factors, depression and disorganization/mania, distinguished the eventual first-episode diagnosis of affective psychosis from schizophrenia. Individuals with affective psychosis were also more likely to have a ‘mood-related’ sign and symptom as their first psychiatric change than individuals later diagnosed with schizophrenia.ConclusionsFactors derived from early signs and symptoms reported by a full diagnostic spectrum sample of psychosis can have implications for future diagnostic trajectories. The findings are a step forward in the process of understanding and characterizing clinically important phenomena to be observed prior to the onset of psychosis.

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Korolev, M. A., E. A. Letyagina, and N. E. Banshchikova. "Rheumatic polymyalgia on the background of prostate adenocarcinoma." Clinical Medicine (Russian Journal) 98, no. 2 (July 15, 2020): 153–56. http://dx.doi.org/10.30629/0023-2149-2020-98-2-153-156.

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Paraneoplastic syndromes diagnosed in 7–10% of patients with malignancies in general. PNS accompany bronchogenic lung, breast, ovarian, prostate, kidney and uterus cancers most often. Neoplastic process can cause by both the acute and the chronic inflammatory response with pathologic changes of the connective tissues and vascular in various organs and systems. Diagnosis of paraneoplastic syndromes is difficult often. However, some signs should cause of rheumatologist the oncologic alertness, which were found in patients with rheumatic masks of neoplasms. Among such signs include: the occurrence of rheumatic diseases in an abnormal age; the absence of sexual dimorphism, is typical of many rheumatic diseases; the difference between the severity of clinical manifestations and the general condition of the patient with an index of inflammatory activity; the absence of separate clinical and laboratory signs typical one or another rheumatic disease; the appearance of new symptoms, not characteristic of the rheumatic diseases. As a clinical example to illustrate the difficulty of diagnosis, this article describes a clinical case of adenocarcinoma of the prostate in 74-year-old men presenting as polymyalgia rheumatica.

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Liaw, C. C., J. S. Chen, H. K. Chang, J. S. Huang, T. S. Yang, and C. T. Liau. "Symptoms and signs of port-related infections in oncology patients related to the offending pathogens." International Journal of Clinical Practice 62, no. 8 (April 14, 2008): 1193–98. http://dx.doi.org/10.1111/j.1742-1241.2008.01746.x.

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Stepanov, N., Z. Duvayarov, I, Bystrova, T. Chepaikina, and V. Kostrova. "Optimization of Early Diagnostics of Prostate Cancer." Bulletin of Science and Practice 6, no. 5 (May 15, 2020): 97–104. http://dx.doi.org/10.33619/2414-2948/54/12.

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The prevalence and incidence of prostate cancer is gradually increasing both in our country and in countries near and far abroad. The difficulties in the differential diagnosis of prostate cancer are convincingly evidenced by the fact that the level of diagnostic errors reaches 40%. It should be noted that in assessing the differential diagnostic capabilities of the indicators of the clinical and special examination methods for patients with lower urinary tract symptoms, disagreements were found in 46–77% of the analyzed clinical signs, the changes of which mainly reflect the negative nature of the effect of tumor decay products on the patient’s body. The aim of the study was to improve the early diagnosis of prostate cancer by using the mathematical method of differential diagnosis of prostate pathology, as well as the rationale for the proposed method for early diagnosis of prostate cancer in patients with clinical symptoms. Using our proposed method for early diagnosis of prostate cancer makes the diagnosis not only reliable and accurate, but also independent of the level of qualification of the urologist and his personal experience, allows you to unify, optimize and personify the differential diagnosis of prostatic hypertrophy and prostate cancer.

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Pastore, Marco R., Rossella D’Aloisio, Gabriella Cirigliano, Chiara De Giacinto, and Daniele Tognetto. "Orbital metastasis as presenting symptom from a prostatic adenocarcinoma." European Journal of Ophthalmology 30, no. 1 (March 4, 2019): NP29—NP32. http://dx.doi.org/10.1177/1120672119832182.

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Purpose: To report a 72-year-old man with orbital metastasis as presenting symptoms from a prostatic adenocarcinoma. Methods: A complete ophthalmological evaluation with ultrasonography examination, kinetic perimetry, fluorescein angiography, and visually evoked potentials were performed. The patient underwent computed tomography, magnetic resonance imaging of the orbit, and blood test for confirmation of the diagnosis. Bone infiltration rate of the cancer was evaluated with bone scintigraphy. Type of the tumor was assessed with orbital incision biopsy and histological analysis. The patient received systemic chemotherapy. Due to poor patient compliance, radiotherapy was not performed. Results: Ultrasonography showed a hypoechoic retrobulbar lesion. At computed tomography examination of the orbit an expansive oval intraconical solid lesion with enhancement after medium contrast was found. Biopsy findings revealed a moderately differentiated adenocarcinoma with immunohistochemical profile supporting prostate as the primary tumor site: negative for cytokeratin-7 and cytokeratin-20 and positive for prostate-specific antigen, prostate-specific acid phosphatase, and alpha-methylacyl-CoA-racemase. Conclusions: Ocular signs and symptoms as first clinical presentation of a prostate cancer are relatively rare. Despite its very poor prognosis, a correct management and therapy can improve visual acuity, ocular symptoms, and median survival of cancer patients.

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Baum, Karl A., Uwe Hopf, Christian Nehrig, Matthias Stöver, and Wolfgang Schörner. "Systemic lupus erythematosus: neuropsychiatric signs and symptoms related to cerebral MRI findings." Clinical Neurology and Neurosurgery 95, no. 1 (March 1993): 29–34. http://dx.doi.org/10.1016/0303-8467(93)90088-x.

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Svensson, B. J., E. S. Dylke, L. C. Ward, D. A. Black, and Sharon L. Kilbreath. "Screening for breast cancer–related lymphoedema: self-assessment of symptoms and signs." Supportive Care in Cancer 28, no. 7 (October 22, 2019): 3073–80. http://dx.doi.org/10.1007/s00520-019-05083-7.

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Matthews, Emma, Louise Hartley, Richa Sud, Michael G. Hanna, Francesco Muntoni, and Pinki Munot. "Acetazolamide can improve symptoms and signs in ion channel-related congenital myopathy." Journal of Neurology, Neurosurgery & Psychiatry 90, no. 2 (May 16, 2018): 243–45. http://dx.doi.org/10.1136/jnnp-2017-317849.

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Lee, Hyung Rock, Jacob E. Resch, Tae Kyung Han, Jessica D. Miles, and Michael S. Ferrara. "Sport-Related Concussion Knowledge and Occurrence: A Survey of High School and College Athletes in South Korea." International Journal of Athletic Therapy and Training 21, no. 2 (March 2016): 53–60. http://dx.doi.org/10.1123/ijatt.2014-0087.

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Few studies have been conducted on individuals’ knowledge of sport-related concussions (SRCs) in South Korea. The purpose of this study was to examine South Korean athletes’ knowledge and recognition of SRC. A cross-sectional survey assessing (a) the recognition of specific signs and symptoms associated with SRC; (b) history of SRC; and (c) knowledge of the return-to-play decision (RTP) process after SRC was distributed to 410 high school and collegiate student-athletes from a variety of sports. No participants correctly identified all 9 items on the checklist of SRC signs and symptoms. While 8.9% reported a history of SRC, approximately 50% of those never reported their postconcussion signs and symptoms. Furthermore, 63.9% of the athletes who reported SRC made RTP decisions on their own. These results reflect the lack of knowledge in South Korean athletics of common signs, symptoms, and appropriate RTP decisions following concussion.

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Niżański, Wojciech, Małgorzata Ochota, Christelle Fontaine, and Joanna Pasikowska. "Comparison of Clinical Effectiveness of Deslorelin Acetate and Osaterone Acetate in Dogs with Benign Prostatic Hyperplasia." Animals 10, no. 10 (October 21, 2020): 1936. http://dx.doi.org/10.3390/ani10101936.

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This article presents the results of a randomized clinical trial, designed to compare the efficacy and therapeutic profiles of YpozaneTM (osaterone acetate—OA) or SuprelorinTM (deslorelin acetate—DA) in male dogs with clinical signs of benign prostate hyperplasia (BPH). Forty-five intact male dogs were used in the study. The Group I (negative control) included 10 healthy dogs, the Group II (positive control) included 10 dogs with confirmed BPH and no treatment, whereas Group III and IV consisted of dogs with BPH and treated either with DA (15 dogs) or OA (10 dogs). The clinical response, testosterone and estradiol levels, hematology, biochemistry, and adverse effects incidence were evaluated. Both OA and DA proved to be effective for BPH treatment in dogs, as they allowed for the clinical remission in all treated dogs. The complete alleviation of BPH symptoms was noticed sooner with the use of OA (in 80% of dogs from day 7) compared to DA (in 40% of dogs within the first 21 days). The recurrence of clinical signs related to BPH was observed from week 24 in dogs treated with OA, whereas no relapse was noticed in dogs treated with DA at the end of the 36 weeks of the observation period. In 5 dogs (33%) treated with DA, a flare-up effect (increase in the clinical signs associated with BPH) was noticed on day 7. Despite individual differences in the clinical action, both medications were effective and safe options for the treatment of symptoms related to BPH in dogs.

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Lechien, Jerome R. "Do Otolaryngologists Over- or Underestimate Laryngopharyngeal Reflux Symptoms and Findings in Clinical Practice? A Comparison Study between the True Prevalence and the Otolaryngologist-Estimated Prevalence of Symptoms and Findings." Journal of Clinical Medicine 11, no. 17 (September 1, 2022): 5192. http://dx.doi.org/10.3390/jcm11175192.

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Purpose: To investigate the prevalence of symptoms and signs of laryngopharyngeal reflux (LPR) and to compare them with the otolaryngologist-estimated prevalence of the most common LPR-related symptoms and signs. Methods: The prevalence of LPR symptoms and signs was determined through the clinical data of 403 patients with a positive LPR diagnosis on hypopharyngeal–esophageal multichannel intraluminal impedance pH monitoring. The otolaryngologist-estimated prevalence was assessed through an international survey investigating the thoughts of 824 otolaryngologists toward LPR symptom and sign prevalence. The determination of potential over- or underestimation of LPR symptoms and findings was investigated through a data comparison between the ‘true’ prevalence and the ‘estimated prevalence’ of symptoms and findings by otolaryngologists. Results: The prevalence of breathing difficulties, coated tongue, and ventricular band inflammation was adequately evaluated by otolaryngologists. The prevalence of hoarseness, throat pain, odynophagia, dysphagia, throat clearing, globus sensation, excess throat mucus, tongue burning, heartburn, regurgitations, halitosis, cough after eating or lying down, and troublesome cough was overestimated by otolaryngologists (p < 0.01), while the prevalence of chest pain was underestimated as an LPR symptom. Most laryngeal signs, e.g., arytenoid/laryngeal erythema, inter-arytenoid granulation, posterior commissure hypertrophy, retrocricoid edema/erythema, and endolaryngeal sticky mucus, were overestimated (p < 0.01). The occurrence of anterior pillar erythema and tongue tonsil hypertrophy was underestimated by participants. Conclusion: Most laryngopharyngeal reflux symptoms and laryngeal signs were overestimated by otolaryngologists, while some non-laryngeal findings were underestimated. Future studies are needed to better understand the reasons for this phenomenon and to improve the awareness of otolaryngologists toward the most and least prevalent reflux symptoms and signs.

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HEMADY, RAMZI K., VICTORIA J. SINIBALDI, and MARIO A. EISENBERGER. "Ocular Symptoms and Signs Associated With Suramin Sodium Treatment for Metastatic Cancer of the Prostate." American Journal of Ophthalmology 121, no. 3 (March 1996): 291–96. http://dx.doi.org/10.1016/s0002-9394(14)70277-6.

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Gugel, Isabel, Florian Grimm, Christian Teuber, Julian Zipfel, Marcos Tatagiba, Victor-Felix Mautner, Martin Ulrich Schuhmann, and Lan Kluwe. "Presenting symptoms in children with neurofibromatosis type 2." Child's Nervous System 36, no. 10 (June 15, 2020): 2463–70. http://dx.doi.org/10.1007/s00381-020-04729-w.

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Abstract Purpose The hallmark of neurofibromatosis type 2 (NF2) is the presence of bilateral vestibular schwannomas (VS) which however have not yet developed or grown to large size in children and young adolescents. Therefore, early diagnosis in pediatric patients without family history of NF2 has to be made by signs and symptoms not related to VS which will be reviewed in this study. Methods A total of 70 children diagnosed for NF2 at an age of < 18 years were identified from our patient cohort. Age and symptoms, signs and pathology at symptom onset, age at NF2 diagnosis and symptoms leading to diagnosis as well as genetic findings were retrospectively reviewed. Results The average age at symptom/sign onset was 8 ± 6 (range 0–17) years and 11 ± 5 (range 1–17) years at time of diagnosis. Fifteen children had a positive family history and were diagnosed upon additional clinical symptoms. The most frequent first presenting symptom/signs were ophthalmological abnormalities (49%), followed by cutaneous features (40%), non-VS-related neurological deficits (33%), and symptoms attributable to VS (21%). VS were not only the most common symptomatic neoplasm but also the most frequent pathological evidence for the diagnosis (72%). In 42 patients with available genetic testing results, pathogenic mutations were most frequently identified (n = 27). Conclusion The presenting symptoms in NF2 children appear “unspecific” or less specific for classical NF2 compared with adult NF2 patients, posing a challenge particularly for cases without family history. In children, ophthalmological and cutaneous features should raise clinical suspicion for NF2 and referral to an NF2 specialized center is recommended.

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Hui, Christy LM, Gloria HY Wong, Cindy PY Chiu, May ML Lam, and Eric YH Chen. "Potential Endophenotype for Schizophrenia: Neurological Soft Signs." Annals of the Academy of Medicine, Singapore 38, no. 5 (May 15, 2009): 408–13. http://dx.doi.org/10.47102/annals-acadmedsg.v38n5p408.

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Introduction: Neurological soft signs (NSS) are suggested as a candidate endophenotype for schizophrenia. This article aims to review relevant literature and discuss the role of NSS in understanding schizophrenia. Methods: This is an update on a review article published in 2003. Articles from 2003 onwards were specifically reviewed and discussed with relevance to the role of NSS as endophenotype for schizophrenia. Results: Consistent data suggest an excess of NSS in schizophrenic patients. NSS appear to be related to schizophrenic symptoms, in particular negative symptoms and disorganisation. Information on NSS and demographic correlates is scarce, and the confounding effects between age, education and intelligence on NSS constitute an important gap in current knowledge. Longitudinal data suggest NSS as both a trait and state variable in the course of disease. NSS are not specific with regard to diagnosis, although there are claims that individual sub-components may be more specific. The weight of evidence raises question on the specificity of NSS for schizophrenia. Conclusions: The usefulness and feasibility of NSS as a specific endophenotype target for schizophrenia is unclear. However, NSS remain an important feature and symptom correlate of schizophrenia. Future research should focus on delineating the effects of NSS from those of confounding demographic variables, and the stability of NSS over the course of illness to elucidate its role in schizophrenia. Key words: Diagnostic specificity, Neurological examination abnormalities, Psychotic symptoms, Review, Trait

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Weber, Priscila, Eliane Castilhos Rodrigues Corrêa, Fabiana dos Santos Ferreira, Juliana Corrêa Soares, Geovana de Paula Bolzan, and Ana Maria Toniolo da Silva. "Cervical spine dysfunction signs and symptoms in individuals with temporomandibular disorder." Jornal da Sociedade Brasileira de Fonoaudiologia 24, no. 2 (2012): 134–39. http://dx.doi.org/10.1590/s2179-64912012000200008.

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PURPOSE: To study the frequency of cervical spine dysfunction (CCD) signs and symptoms in subjects with and without temporomandibular disorder (TMD) and to assess the craniocervical posture influence on TMD and CCD coexistence. METHODS: Participants were 71 women (19 to 35 years), assessed about TMD presence; 34 constituted the TMD group (G1) and 37 comprised the group without TMD (G2). The CCD was evaluated through the Craniocervical Dysfunction Index and the Cervical Mobility Index. Subjects were also questioned about cervical pain. Craniocervical posture was assessed by cephalometric analysis. RESULTS: There was no difference in the craniocervical posture between groups. G2 presented more mild CCD frequency and less moderate and severe CCD frequency (p=0.01). G1 presented higher percentage of pain during movements (p=0.03) and pain during cervical muscles palpation (p=0.01) compared to G2. Most of the TMD patients (88.24%) related cervical pain with significant difference when compared to G2 (p=0.00). CONCLUSION: Craniocervical posture assessment showed no difference between groups, suggesting that postural alterations could be more related to the CCD. Presence of TMD resulted in higher frequency of cervical pain symptom. Thus the coexistence of CCD and TMD signs and symptoms appear to be more related to the common innervations of the trigeminocervical complex and hyperalgesia of the TMD patients than to craniocervical posture deviations.

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Nagy, Z. Z. "Ophthalmic signs and complications of the COVID-19 infection." Developments in Health Sciences 3, no. 4 (July 30, 2021): 79–82. http://dx.doi.org/10.1556/2066.2021.40001.

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AbstractCoronavirus-19 infection caused a mysterious pandemic worldwide. Some people experienced flu-like symptoms, while others have died due to pulmonary complications. Besides droplet spread, other routes of infection started to be suspected, such as through eye contact. During the first phase of the pandemic, pulmonary symptoms were in focus, later other signs and symptoms were also published. Eyelid, anterior and posterior segment symptoms, neuro-ophthalmic complications, and orbital problems related to COVID-19 infections are discussed in this article. It is important to detect the serious signs and symptoms to prevent late, sight threatening complications of COVID-19 infection.

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Kaplan, Steven, Claus Roehrborn, Lawrence A. Hill, and Weining Volinn. "Effect of estimated prostate volume on silodosin-mediated improvements in the signs and symptoms of BPH: does prostate size matter?" Research and Reports in Urology Volume 3 (June 2011): 89–93. http://dx.doi.org/10.2147/rru.s18941.

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Mills, Hilla, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, and Thang Nguyen Van. "Preparation of PCL Electrospun Fibers Loaded with Cisplatin and Their Potential Application for the Treatment of Prostate Cancer." Emergency Medicine International 2022 (July 15, 2022): 1–8. http://dx.doi.org/10.1155/2022/6449607.

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Prostate cancer is a global fatal type of cancer. It is a type of cancer that affect men. Signs and symptoms of the disease include blood in the urine, pain when one micturates, and difficulties in penis erection. Cisplatin chemotherapy is a principal treatment normally given to the prostate cancer patients. Nonetheless, on its own, cisplatin loses efficacy once administered due to liver pass effects and other biochemical attacks. In this paper, we looked at preparation of PCL nanoparticles loaded with cisplatin and their potential for the treatment of prostate cancer. PCL nanoparticles protect cisplatin from biochemical attack, thus increasing drug efficacy. Incorporation of P-glycoprotein inhibitors in PCL nanoparticles (NPs) loaded with cisplatin could improve prostate cancer treatment even more.

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Piggott, Cleveland A., Sheryl Zimmerman, David Reed, and Philip D. Sloane. "Development and Testing of a Measure of Caregiver Confidence in Medical Sign/Symptom Management." American Journal of Alzheimer's Disease & Other Dementiasr 32, no. 7 (May 30, 2017): 373–81. http://dx.doi.org/10.1177/1533317517711247.

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Evaluation of efforts to support family caregivers of people with dementia in their daily medical management responsibilities requires a measure of caregiver self-efficacy (confidence). This article describes the development and psychometric properties of the Caregiver Confidence in Sign/Symptom Management (CCSM) scale, the only available instrument in this area. Measurement development included literature and expert panel review, cognitive testing, and field testing. The CCSM is a 25-item measure (α = .92) composed of confidence in relation to 4 subscales: knowledge of signs/symptoms (α = .83), management of cognitive signs/symptoms (α = .85), management of medical signs/symptoms (α = .87), and general medication management/responsiveness (α = .85), all of which relate to caregiver role strain. The CCSM is a reliable and valid instrument to assess caregiver confidence in sign/symptom management and is useful to determine caregiver needs and outcomes of related interventions. Additionally, it furthers understanding of the role of self-efficacy in caregiver quality of life.

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Huh, Jung-Sik, Young-Joo Kim, and Sung Dae Kim. "Clinical diagnosis and treatment of late-onset hypogonadism." Journal of Medicine and Life Science 9, no. 2 (December 1, 2012): 117–22. http://dx.doi.org/10.22730/jmls.2012.9.2.117.

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Testosterone is the principal androgen in the human male. The decline of testosterone with aging was recognized to be associated with a number of symptoms and signs that reduce the quality of life and that may even have severe, debilitating consequences. So testosterone deficiency in the aging male has become a topic of increasing interest and debate throughout the world. Clinically, late-onset hypogonadism (LOH) is diagnosed by the presence of symptoms or signs and persistent low serum testosterone levels. The benefits and risks of testosterone therapy must be clearly discussed with the patient and assessment of prostate and other risk factors considered before commencing testosterone treatment. Response to testosterone treatment should be assessed. It there is no improvement of symptoms and signs, treatment should be withdrawn and the patient investigated for other possible causes of the clinical presentations. Overall, the problem of LOH in debilitating the quality of life and well-being is real, and by following proper guidelines with attentiveness to the results of treatment trials, testosterone replacement therapy presents a safe and effective treatment option.

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Beidler, Erica, Abigail C. Bretzin, Colin Hanock, and Tracey Covassin. "Sport-Related Concussion: Knowledge and Reporting Behaviors Among Collegiate Club-Sport Athletes." Journal of Athletic Training 53, no. 9 (September 1, 2018): 866–72. http://dx.doi.org/10.4085/1062-6050-266-17.

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Context: Previous literature on sport-related concussion (SRC) knowledge and reporting behaviors has been limited to high school and National Collegiate Athletic Association collegiate athletes; however, knowledge regarding collegiate club-sport athletes is limited. Objective: To determine the level of SRC knowledge and reporting behaviors among collegiate club-sport athletes and to investigate differences between athletes in traditional and nontraditional sports. Design: Cross-sectional study. Setting: Survey. Patients or Other Participants: A total of 410 athletes (247 males, 163 females) involved in traditional (n = 244) or nontraditional (n = 165) collegiate club sports. Main Outcome Measure(s): The survey consisted of demographics, recognition of SRC signs and symptoms, general SRC knowledge, and reasons why athletes would not report SRCs. The independent variable was sport type. Sport-related concussion signs and symptoms and general knowledge were assessed by the frequency of correct answers to SRC signs and symptoms and general knowledge questions. Sport-related concussion-reporting behavior frequencies were evaluated by asking participants to indicate reasons why they did not or would not report an SRC. Results: The SRC signs and symptoms knowledge score was 23.01 ± 3.19 and general SRC knowledge score was 36.49 ± 4.16 (maximal score = 43). No differences were present for SRC signs and symptoms knowledge (F1,408 = 1.99, P = .16) or general SRC knowledge (F1,408 = 3.28, P = .07) between athletes in traditional and nontraditional collegiate club sports. The most common reason for not reporting an SRC was not recognizing it as a serious injury (n = 165, 40.3%). Chi-square tests demonstrated significant relationships between sport type and 5 reasons for not reporting an SRC. Conclusions: The participants displayed moderate to high levels of knowledge of SRCs but indicated they had failed to or would fail to report SRCs for a variety of reasons. The lack of sports medicine coverage and disconnect between knowledge and injury recognition may make collegiate club-sport athletes more likely to participate while concussed.

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Ernst, G., A. Gericke, and P. Berg. "Central Pain and Complex Motoric Symptoms after Gosarelin Therapy of Prostate Cancer." Scientific World JOURNAL 4 (2004): 969–73. http://dx.doi.org/10.1100/tsw.2004.197.

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A 76-year-old man with prostate cancer T3N0M0 and increasing PSA was treated with goserelin three times in a half year. As soon as the first treatment, he described subjective muscle weakness. After the third treatment, he developed complex motoric symptoms and atypical central pain with a likely association to goserelin. His left arm had signs of spastic movement; pain deteriorated after relaxation. The right hand showed muscle cramps under passive movements of the left arm that were not typical for rigor. He felt aching and partial burning pain in his whole body. There were few allodynic areas, mainly in the left arm. Several treatment approaches failed and the patient died some weeks after the first contact with our pain clinic due to pneumonia.

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Majoie, C. B., F. J. Hulsmans, J. A. Castelijns, B. Verbeeten, D. Tiren, E. J. van Beek, J. Valk, and D. A. Bosch. "Symptoms and signs related to the trigeminal nerve: diagnostic yield of MR imaging." Radiology 209, no. 2 (November 1998): 557–62. http://dx.doi.org/10.1148/radiology.209.2.9807589.

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Kianifar, HR, J. Akhondian, H. Khoshmohabat, H. yosefzadeh, A. khakshour, A. Ezzati khorasani, and S. H. Hosseini. "Gastrointestinal symptoms and other related signs in infants with Cow’s Milk Protein Allergy." Journal of North Khorasan University of Medical Sciences 4, no. 3 (December 1, 2012): 475–80. http://dx.doi.org/10.29252/jnkums.4.3.475.

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Karbassi, Esmat, Ehsan Amiri-Ardekani, Alireza Farsinezhad, Armita Shahesmaeili, Yasaman Abhari, Mahsa Ziaesistani, Noushin Pouryazdanpanah, Ali Derakhshani, Fatemeh Jamshidi, and Haleh Tajadini. "The Efficacy of Kohl (Surma) and Erythromycin in Treatment of Blepharitis: An Open-Label Clinical Trial." Evidence-Based Complementary and Alternative Medicine 2022 (January 24, 2022): 1–6. http://dx.doi.org/10.1155/2022/6235857.

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Introduction. Blepharitis is a common and chronic form of eyelid inflammation. Blepharitis treatment aims to decrease symptoms through antibacterial effects. One of the most common treatments of eyelid diseases in traditional medicine is using kohl. This clinical trial aimed to investigate its efficacy as a complementary treatment in staphylococcal blepharitis through an open-label clinical trial. Materials and Methods. Thirty patients were randomized to receive kohl in one eye contralateral and erythromycin ointment in another eye for 90 days. At baseline and after 90 days of treatment, symptoms, clinical signs, and side effects of treatments were recorded. Statistical analysis was carried out using SPSS software, version 19. Results. Despite randomization, there was a significant difference between the intervention and control eyes in the baseline mean clinical score (intervention eye: 9.86 (2.95) and control eye: 4.30 (2.81), P < 0.001 ). The degree of reduction of related signs and symptoms in the eyes treated with kohl was significantly higher than that in the control group: (5.2 vs. 2.20, P < 0.001 ) for symptoms and (7.40 vs. 2.46, P < 0.001 ) for clinical signs. Cohen’s d statistic for mean difference of sign and symptom was 2.4 and 1.75, respectively, indicating a very strong effect. Conclusion. The present study results demonstrated a significant improvement in blepharitis-related signs and symptoms. The degree of improvement in the eyes treated with kohl was much higher than that in the control eyes.

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Ong, Erin S., Elizabeth R. Felix, Roy C. Levitt, William J. Feuer, Constantine D. Sarantopoulos, and Anat Galor. "Epidemiology of discordance between symptoms and signs of dry eye." British Journal of Ophthalmology 102, no. 5 (August 18, 2017): 674–79. http://dx.doi.org/10.1136/bjophthalmol-2017-310633.

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Background/aimsThe frequent lack of association between dry eye (DE) symptoms and signs leads to challenges in diagnosing and assessing the disease.MethodsParticipants underwent ocular surface examinations to evaluate signs of disease and completed questionnaires to assess ocular symptoms, psychological status and medication use. To assess nociceptive system integrity, quantitative sensory testing (QST), including vibratory and thermal threshold measures and temporal summation of pain were obtained at the forearm and forehead. Correlations between DE discordance score (degree of discrepancy between symptom severity and DE signs) and patient characteristics were determined. Higher discordance scores indicated more symptoms than signs.Results326 patients participated (mean age: 62 years; SD: 10 years; 92% men). Age was negatively correlated with DE discordance score (Pearson r=−0.30, p<0.0005), while mental health indices were positively correlated. Chronic pain elsewhere in the body (ie, non-ocular pain conditions) and intensity ratings of prolonged aftersensations of pain evoked by noxious hot and cold stimuli were also significantly correlated with DE discordance score. Multiple linear regression demonstrated that post-traumatic stress disorder and non-ocular pain intensity were important predictors of DE discordance score, Dry Eye Questionnaire-5 and Ocular Surface Disease Index and that DE discordance was also sensitive to QST as well.ConclusionsThe present study provides evidence that the degree of discordance between DE symptom report and measurable signs of ocular surface disease is associated with comorbidities related to clinical pain and to hyperalgesia as demonstrated with QST. Understanding the epidemiology of DE discordance can aid in interpreting the DE exam and individualising treatment.

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Koca, Tuba, Ozer Erzurumluoglu, and Burhan Kocyigit. "Miscellaneous neuromuscular symptoms and signs in long Covid." Medicine Science | International Medical Journal 12, no. 1 (2023): 238. http://dx.doi.org/10.5455/medscience.2022.12.259.

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We have completed the 3rd year of the Covid-19 pandemic. In the early stages of the disease, we were faced with a wide variety of symptoms and signs, including the neuromuscular system, as well as life-threatening cardiopulmonary, neurovascular and immun complications. In our study, we questioned fatigue, myalgia, arthralgia, dyspnea, headache, dizziness, neck pain, back pain, low back pain, knee-hip-foot joint pain, vascular claudication (lower extremity pain/cramp), neuropathic pain, morning stiffness, joint swelling, pernio, imbalance in walking in patients (N=111; 65 female, 29 male) aged 20-59 years, who applied to our outpatient clinic in the last 1 year and had Covid-19. The mean time after Covid-19 was 5.8 ±2.1 months. The duration of Covid-19 treatment was a minimum of 5 days and a maximum of 12 days (median=5 days). Weight loss in 14.4% (median=3.5 kg), anorexia 17.1%, myalgia 41.4% (visual analog scale, VAS=5.1±1.9 cm), arthralgia 24.3% (VAS=5.1±2 cm), fatigue 63.1%, joint swelling 1.8%, pernio sign 0.9%, morning stiffness 7.2% (median=15 min, min 5-maximum 60 min), headache 39.6%, neuropathic pain 15.3%, effort dyspnea 38.7%, 30 second chair stand test= 14.9 ±3.6, vascular claudication symptom 11.7%, neck pain 27.0%, low back pain 30.6%, back pain 36%, hip-knee-foot pain 18.0%, gait imbalance 1.8%, dizziness 18.9% were observed. While fatigue (p=0.05), headache (p=0.04), and dyspnea (p=0.021) complaints were higher in males; VAS (arthralgia) was found higher in females (p=0.026). In the post-Covid-19 period, we see many neuromuscular symptoms and signs, especially fatigue, myalgia, headache and back pain. In addition, lower extremity vascular claudication and neuropathic pain related with chronic pain should not be overlooked in these patients.

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Woroń, Jarosław, Dariusz Jurkiewicz, Piotr Rapiejko, Barbara Lorkowska- Zawicka, Radosław Tymiński, and Jerzy Wordliczek. "Drug-induced diseases in otolaryngology – causes, clinical signs, treatment." Otolaryngologia Polska 75, no. 2 (February 16, 2021): 1–5. http://dx.doi.org/10.5604/01.3001.0014.7445.

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Introduction: In the daily practice of an otolaryngologist, we encounter cases where the symptoms are not the result of disease but result from pharmacotherapy. In the case of symptoms such as hearing loss, tinnitus, or dizziness, polytherapy may be used as the basis for their occurrence, which, due to the lack of rationality in combining drugs, leads to symptoms that the patient and the doctor very often interpret as a new disease syndrome. Aim: The aim of the study is to show and to raise awareness of the fact that the symptoms of hearing organ impairment are frequently drug-related and only a modification of the currently used pharmacotherapy is a rational procedure in such cases. Material: This paper describes 30 cases who developed side effects of polypharmacy in the form of hearing disorders, dizziness, and tinnitus. The causes of drug-related complications were discussed, as well as effective methods of their prevention.

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França, Inacia Sátiro Xavier de, Isabella Medeiros de Oliveira Magalhães, Francisco Stélio de Sousa, Alexsandro Silva Coura, Arthur Felipe Rodrigues Silva, and Rosilene Santos Baptista. "CLINICAL SIGNS AND SYMPTOMS OF SEXUALLY TRANSMITTED INFECTIONS COMMUNICATED IN LIBRAS." Revista da Escola de Enfermagem da USP 50, no. 3 (June 2016): 458–65. http://dx.doi.org/10.1590/s0080-623420160000400012.

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Abstract OBJECTIVE To validate a video containing image representations of clinical signs and symptoms of sexually transmitted infections expressed in Libras. METHOD Methodology development study conducted in an audio communication school. Thirty-six deaf people were selected. A video containing image representations of clinical signs and symptoms of sexually transmitted infections expressed in Libras was produced. Semantic validation was performed by deaf students and content validation by three judges who are Libras experts. The validation results were subjected to the Content Validity Index, where an index score > 0.80/80% was considered as agreement among judges. RESULTS Seven signs and symptoms related to sexually transmitted infections were validated and obtained satisfactory Content Validity Indexes, most of them with 100% representativeness and agreement. CONCLUSION The validation process made the expressions of signs and symptoms related to sexually transmitted infections represented in Libras valid for establishing effective communication in the area of the study, turning it into a care tool that facilitates and standardizes communication with deaf people through Libras.

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Awuni, V., HK Garti, and FK Amagloh. "Knowledge of prostate health and food choice influence on the risk of prostate disorders among Ghanaian men." African Journal of Food, Agriculture, Nutrition and Development 22, no. 112 (October 5, 2022): 20883–904. http://dx.doi.org/10.18697/ajfand.112.21935.

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Understanding prostate health is vital for preventing, managing, and treating prostate disorders. Prostate disorder is a significant health challenge among men, and if not detected early, could lead to complications like cancer and death. Thus, knowledge of prostate health is essential for defining critical areas of intervention among men. This was a cross-sectional survey conducted among 894 Ghanaian men aged 40 to 70+ to assess their knowledge of prostate health and its influence on their food choices. The study was conducted in Greater Accra, Bono, and Northern Regions of Ghana. A structured questionnaire was employed to collect data on socio-demographics, knowledge of prostate health and consumption of foods related to prostate health. Two categories of foods, relating to prostate health were considered for the study: protective foods (fruits and vegetables) and high-risk foods (alcohol, meat, and meat products). Knowledge level scores were computed from the marks scored by participants on prostate health risk factors, causes, signs, symptoms and treatment, and nutrition and prostate health. Food choices were assessed based on the frequency of protective foods and high-risk foods intake. Associations between socio-demographic characteristics, knowledge level of prostate health, and food choices were examined using bivariate analysis, and multivariate regression analysis was conducted for possible predictors. The mean age of participants was 51.44 ±7.98. More than half of the participants (62.5%, n=559) had a high knowledge of prostate health. Participants with a family history of prostate disorders were approximately two times [OR (odds ratio) =1.973, p=0.041] more likely to have a high knowledge level of prostate health than those with no family history. Similarly, those diagnosed with prostate disorders were three times (OR = 2.736, p<0.001) more likely to have a high knowledge level of prostate health than those who have never been diagnosed of any prostate disorder. Generally, participants consumed protective and high-risk foods related to prostate health. Participants with increased knowledge of prostate health were three times (OR=2.531, p<0.001) more likely to consume protective foods. Knowledge about prostate health through experience positively impacts the consumption of fruits and vegetables. Efforts in Ghana to improve prostate health should include education on protective food choices to promote prostate health. Key words: Food choice, Knowledge, Men, Nutrition knowledge, Prostate health, Protective foods

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Penque, S., M. Halm, M. Smith, J. Deutsch, M. Van Roekel, L. McLaughlin, S. Dzubay, N. Doll, and M. Beahrs. "Women and coronary disease: relationship between descriptors of signs and symptoms and diagnostic and treatment course." American Journal of Critical Care 7, no. 3 (May 1, 1998): 175–82. http://dx.doi.org/10.4037/ajcc1998.7.3.175.

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BACKGROUND: Heart disease is the No. 1 killer among women in the United States. Differences in the clinical features of coronary heart disease among men and women have been reported, along with various approaches to the diagnostic workup and therapeutic interventions. PURPOSE: To explore the relationship between descriptors of signs and symptoms of coronary heart disease and follow-up care and to investigate any differences between male and female patients. METHODS: Structured interviews with patients and chart audits were used to assess initial signs and symptoms, associated cardiac-related signs and symptoms, and the diagnostic tests and interventions used for treatment. The sample consisted of 98 patients (51 women and 47 men) who were admitted with a medical diagnosis of myocardial infarction. RESULTS: Chest pain was the most common sign or symptom reported by both men and women. The 4 most common associated signs and symptoms were identical in men and women: fatigue, rest pain, shortness of breath, and weakness. However, significantly more women than men reported loss of appetite, paroxysmal nocturnal dyspnea, and back pain. Women were also less likely than men to have angiography and to receive i.v. nitroglycerin, heparin, and thrombolytic agents as part of acute management of myocardial infarction. CONCLUSION: Chest pain remains the initial symptom of acute myocardial infarction in both men and women. However, women may experience some different associated signs and symptoms than do men. Despite these similarities, men still are more likely than women to have angiography and to receive a number of therapies.

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