Добірка наукової літератури з теми "Pro-Resolving factors"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Pro-Resolving factors".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Pro-Resolving factors":
1
Schilke, Robert M., Cassidy M. R. Blackburn, Temitayo T. Bamgbose, and Matthew D. Woolard. "Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis." Biomolecules 10, no. 10 (October 15, 2020): 1449. http://dx.doi.org/10.3390/biom10101449.
Анотація:
Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phospholipases and the bioactive lipids they produce are important regulators of immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression, respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis.
2
Brennan, Eoin P., Muthukumar Mohan, Darrell Andrews, Madhura Bose, and Phillip Kantharidis. "Specialized pro-resolving mediators in diabetes: novel therapeutic strategies." Clinical Science 133, no. 21 (November 2019): 2121–41. http://dx.doi.org/10.1042/cs20190067.
Анотація:
Abstract Diabetes mellitus (DM) is an important metabolic disorder characterized by persistent hyperglycemia resulting from inadequate production and secretion of insulin, impaired insulin action, or a combination of both. Genetic disorders and insulin receptor disorders, environmental factors, lifestyle choices and toxins are key factors that contribute to DM. While it is often referred to as a metabolic disorder, modern lifestyle choices and nutrient excess induce a state of systemic chronic inflammation that results in the increased production and secretion of inflammatory cytokines that contribute to DM. It is chronic hyperglycemia and the low-grade chronic-inflammation that underlies the development of microvascular and macrovascular complications leading to damage in a number of tissues and organs, including eyes, vasculature, heart, nerves, and kidneys. Improvements in the management of risk factors have been beneficial, including focus on intensified glycemic control, but most current approaches only slow disease progression. Even with recent studies employing SGLT2 inhibitors demonstrating protection against cardiovascular and kidney diseases, kidney function continues to decline in people with established diabetic kidney disease (DKD). Despite the many advances and a greatly improved understanding of the pathobiology of diabetes and its complications, there remains a major unmet need for more effective therapeutics to prevent and reverse the chronic complications of diabetes. More recently, there has been growing interest in the use of specialised pro-resolving mediators (SPMs) as an exciting therapeutic strategy to target diabetes and the chronic complications of diabetes.
3
de Fáveri, Cássia, Paula M. Poeta Fermino, Anna P. Piovezan, and Lia K. Volpato. "The Inflammatory Role of Pro-Resolving Mediators in Endometriosis: An Integrative Review." International Journal of Molecular Sciences 22, no. 9 (April 22, 2021): 4370. http://dx.doi.org/10.3390/ijms22094370.
Анотація:
The pathogenesis of endometriosis is still controversial, although it is known that the inflammatory immune response plays a critical role in this process. The resolution of inflammation is an active process where the activation of endogenous factors allows the host tissue to maintain homeostasis. The mechanisms by which pro-resolving mediators (PRM) act in endometriosis are still little explored. Thus, this integrative review aims to synthesize the available content regarding the role of PRM in endometriosis. Experimental and in vitro studies with Lipoxin A4 demonstrate a potential inhibitory effect on endometrial lesions’ progression, attenuating pro-inflammatory and angiogenic signals, inhibiting proliferative and invasive action suppressing intracellular signaling induced by cytokines and estradiol, mainly through the FPR2/ALX. Investigations with Resolvin D1 demonstrated the inhibition of endometrial lesions and decreased pro-inflammatory factors. Annexin A1 is expressed in the endometrium and is specifically present in women with endometriosis, although the available studies are still inconsistent. Thus, we believe there is a gap in knowledge regarding the PRM pathways in patients with endometriosis. It is important to note that these substances’ therapeutic potential is evident since the immune and abnormal inflammatory responses play an essential role in endometriosis development and progression.
4
Onali, Favale, and Fantini. "The Resolution of Intestinal Inflammation: The Peace-Keeper’s Perspective." Cells 8, no. 4 (April 11, 2019): 344. http://dx.doi.org/10.3390/cells8040344.
Анотація:
The uncontrolled activation of the immune system toward antigens contained in the gut lumen in genetically predisposed subjects is believed to be the leading cause of inflammatory bowel disease (IBD). Two not mutually exclusive hypotheses can explain the pathogenic process leading to IBD. The first and mostly explored hypothesis states that the loss of tolerance toward gut microbiota antigens generates an aberrant inflammatory response that is perpetuated by continuous and unavoidable exposure to the triggering antigens. However, the discovery that the resolution of inflammation is not the mere consequence of clearing inflammatory triggers and diluting pro-inflammatory factors, but rather an active process in which molecular and cellular elements are involved, implies that a defect in the pro-resolving mechanisms might cause chronic inflammation in different immune-mediated diseases, including IBD. Here we review data on pro-resolving and counter-regulatory mechanisms involved in the resolution of inflammation, aiming to identify their possible involvement in the pathogenesis of IBD.
5
Klatte-Schulz, Franka, Nicole Bormann, Aysha Bonell, Jasmin Al-Michref, Hoang Le Nguyen, Pascal Klöckner, Kathi Thiele, et al. "Pro-Resolving Mediators in Rotator Cuff Disease: How Is the Bursa Involved?" Cells 13, no. 1 (December 20, 2023): 17. http://dx.doi.org/10.3390/cells13010017.
Анотація:
So far, tendon regeneration has mainly been analyzed independent from its adjacent tissues. However, the subacromial bursa in particular appears to influence the local inflammatory milieu in the shoulder. The resolution of local inflammation in the shoulder tissues is essential for tendon regeneration, and specialized pro-resolving mediators (SPMs) play a key role in regulating the resolution of inflammation. Here, we aimed to understand the influence of the bursa on disease-associated processes in neighboring tendon healing. Bursa tissue and bursa-derived cells from patients with intact, moderate and severe rotator cuff disease were investigated for the presence of pro-resolving and inflammatory mediators, as well their effect on tenocytes and sensitivity to mechanical loading by altering SPM signaling mediators in bursa cells. SPM signal mediators were present in the bursae and altered depending on the severity of rotator cuff disease. SPMs were particularly released from the bursal tissue of patients with rotator cuff disease, and the addition of bursa-released factors to IL-1β-challenged tenocytes improved tenocyte characteristics. In addition, mechanical loading modulated pro-resolving processes in bursa cells. In particular, pathological high loading (8% strain) increased the expression and secretion of SPM signaling mediators. Overall, this study confirms the importance of bursae in regulating inflammatory processes in adjacent rotator cuff tendons.
6
Tangeten, Cecilia, Karim Zouaoui Boudjeltia, Cedric Delporte, Pierre Van Antwerpen, and Keziah Korpak. "Unexpected Role of MPO-Oxidized LDLs in Atherosclerosis: In between Inflammation and Its Resolution." Antioxidants 11, no. 5 (April 28, 2022): 874. http://dx.doi.org/10.3390/antiox11050874.
Анотація:
Inflammation and its resolution are the result of the balance between pro-inflammatory and pro-resolving factors, such as specialized pro-resolving mediators (SPMs). This balance is crucial for plaque evolution in atherosclerosis, a chronic inflammatory disease. Myeloperoxidase (MPO) has been related to oxidative stress and atherosclerosis, and MPO-oxidized low-density lipoproteins (Mox-LDLs) have specific characteristics and effects. They participate in foam cell formation and cause specific reactions when interacting with macrophages and endothelial cells. They also increase the production of intracellular reactive oxygen species (ROS) in macrophages and the resulting antioxidant response. Mox-LDLs also drive macrophage polarization. Mox-LDLs are known to be pro-inflammatory particles. However, in the presence of Mox-LDLs, endothelial cells produce resolvin D1 (RvD1), a SPM. SPMs are involved in the resolution of inflammation by stimulating efferocytosis and by reducing the adhesion and recruitment of neutrophils and monocytes. RvD1 also induces the synthesis of other SPMs. In vitro, Mox-LDLs have a dual effect by promoting RvD1 release and inducing a more anti-inflammatory phenotype macrophage, thereby having a mixed effect on inflammation. In this review, we discuss the interrelationship between MPO, Mox-LDLs, and resolvins, highlighting a new perception of the role of Mox-LDLs in atherosclerosis.
7
Costa, Ambra, Davide Ceresa, Antonella De Palma, Rossana Rossi, Sara Turturo, Sara Santamaria, Carolina Balbi, et al. "Comprehensive Profiling of Secretome Formulations from Fetal- and Perinatal Human Amniotic Fluid Stem Cells." International Journal of Molecular Sciences 22, no. 7 (April 2, 2021): 3713. http://dx.doi.org/10.3390/ijms22073713.
Анотація:
We previously reported that c-KIT+ human amniotic-fluid derived stem cells obtained from leftover samples of routine II trimester prenatal diagnosis (fetal hAFS) are endowed with regenerative paracrine potential driving pro-survival, anti-fibrotic and proliferative effects. hAFS may also be isolated from III trimester clinical waste samples during scheduled C-sections (perinatal hAFS), thus offering a more easily accessible alternative when compared to fetal hAFS. Nonetheless, little is known about the paracrine profile of perinatal hAFS. Here we provide a detailed characterization of the hAFS total secretome (i.e., the entirety of soluble paracrine factors released by cells in the conditioned medium, hAFS-CM) and the extracellular vesicles (hAFS-EVs) within it, from II trimester fetal- versus III trimester perinatal cells. Fetal- and perinatal hAFS were characterized and subject to hypoxic preconditioning to enhance their paracrine potential. hAFS-CM and hAFS-EV formulations were analyzed for protein and chemokine/cytokine content, and the EV cargo was further investigated by RNA sequencing. The phenotype of fetal- and perinatal hAFS, along with their corresponding secretome formulations, overlapped; yet, fetal hAFS showed immature oxidative phosphorylation activity when compared to perinatal ones. The profiling of their paracrine cargo revealed some differences according to gestational stage and hypoxic preconditioning. Both cell sources provided formulations enriched with neurotrophic, immunomodulatory, anti-fibrotic and endothelial stimulating factors, and the immature fetal hAFS secretome was defined by a more pronounced pro-vasculogenic, regenerative, pro-resolving and anti-aging profile. Small RNA profiling showed microRNA enrichment in both fetal- and perinatal hAFS-EV cargo, with a stably- expressed pro-resolving core as a reference molecular signature. Here we confirm that hAFS represents an appealing source of regenerative paracrine factors; the selection of either fetal or perinatal hAFS secretome formulations for future paracrine therapy should be evaluated considering the specific clinical scenario.
8
Jain, Paridhi, and Suyesha Singh. "Nature Relatedness, Eco-centric Concerns, Future Time Perspective, and Pro-ecological Behavior in Young Adults." IOP Conference Series: Earth and Environmental Science 1279, no. 1 (December 1, 2023): 012031. http://dx.doi.org/10.1088/1755-1315/1279/1/012031.
Анотація:
Abstract Human civilization poses a grave threat to global biodiversity, evident in climate change, species extinction, infectious diseases, food production challenges, droughts, and floods. To reverse this peril, societal structures and individual behavior must transform. Embracing pro-ecological behavior is pivotal in combating environmental issues, reducing waste, curbing pollutants, and minimizing harm. Furthermore, fostering a connection to nature, embracing sustainability, and adopting a long-term perspective can aid in resolving these challenges. This research explores the link between nature-relatedness, eco-centric concerns, future time perspective, and pro-ecological behavior among 210 young adults. Utilizing multiple regression and Pearson’s correlation, the study reveals significant positive correlations between pro-ecological behavior and nature-relatedness, eco-centric concerns, and future time perspective. Moreover, these factors significantly predict pro-ecological behavior in young adults. These findings offer insights for developing strategies and interventions to nurture pro-ecological and sustainable behavior in future generations, bolstering environmental preservation efforts. The study discusses the limitation and their repercussions.
9
Dalli, Jesmond, Esteban Alberto Gomez, and Charlotte Camille Jouvene. "Utility of the Specialized Pro-Resolving Mediators as Diagnostic and Prognostic Biomarkers in Disease." Biomolecules 12, no. 3 (February 23, 2022): 353. http://dx.doi.org/10.3390/biom12030353.
Анотація:
A precision medicine approach is widely acknowledged to yield more effective therapeutic strategies in the treatment of patients with chronic inflammatory conditions than the prescriptive paradigm currently utilized in the management and treatment of these patients. This is because such an approach will take into consideration relevant factors including the likelihood that a patient will respond to given therapeutics based on their disease phenotype. Unfortunately, the application of this precision medicine paradigm in the daily treatment of patients has been greatly hampered by the lack of robust biomarkers, in particular biomarkers for determining early treatment responsiveness. Lipid mediators are central in the regulation of host immune responses during both the initiation and resolution of inflammation. Amongst lipid mediators, the specialized pro-resolving mediators (SPM) govern immune cells to promote the resolution of inflammation. These autacoids are produced via the stereoselective conversion of essential fatty acids to yield molecules that are dynamically regulated during inflammation and exert potent immunoregulatory activities. Furthermore, there is an increasing appreciation for the role that these mediators play in conveying the biological actions of several anti-inflammatory therapeutics, including statins and aspirin. Identification and quantitation of these mediators has traditionally been achieved using hyphenated mass spectrometric techniques, primarily liquid-chromatography tandem mass spectrometry. Recent advances in the field of chromatography and mass spectrometry have increased both the robustness and the sensitivity of this approach and its potential deployment for routine clinical diagnostics. In the present review, we explore the evidence supporting a role for specific SPM as potential biomarkers for patient stratification in distinct disease settings together with methodologies employed in the identification and quantitation of these autacoids.
10
Sufaru, Irina-Georgeta, Silvia Teslaru, Liliana Pasarin, Gianina Iovan, Simona Stoleriu, and Sorina Mihaela Solomon. "Host Response Modulation Therapy in the Diabetes Mellitus—Periodontitis Conjuncture: A Narrative Review." Pharmaceutics 14, no. 8 (August 18, 2022): 1728. http://dx.doi.org/10.3390/pharmaceutics14081728.
Анотація:
The inflammatory response of the host in periodontitis is the phenomenon that underlies the onset and evolution of periodontal destructive phenomena. A number of systemic factors, such as diabetes mellitus (DM), can negatively affect the patient with periodontitis, just as the periodontal disease can aggravate the status of the DM patient. Host response modulation therapy involves the use of anti-inflammatory and anti-oxidant products aimed at resolving inflammation, stopping destructive processes, and promoting periodontal healing, all important aspects in patients with high tissue loss rates, such as diabetic patients. This paper reviews the data available in the literature on the relationship between DM and periodontitis, the main substances modulating the inflammatory response (nonsteroidal anti-inflammatory drugs, sub-antimicrobial doses of doxycycline, or omega-3 fatty acids and their products, specialized pro-resolving mediators), as well as their application in diabetic patients.
Дисертації з теми "Pro-Resolving factors":
1
Antoine, Thomas. "Sélection d'excipients bioactifs pour la formulation de facteurs pro-résolutifs dans le cadre du traitement des maladies inflammatoires chroniques de l'intestin." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2023. http://indexation.univ-fcomte.fr/nuxeo/site/esupversions/5b779b0b-84fd-4a00-926c-2bf7602807f2.
Анотація:
Les maladies inflammatoires chroniques de l'intestin (MICI) sont des pathologies du tractus gastro-intestinal, caractérisées par des épisodes récurrents d'inflammation avec des périodes de rémission et des symptômes affectant négativement la qualité de vie des patients. Actuellement, le traitement de ces maladies complexes repose principalement sur l’administration par voie orale de molécules chimiques. Néanmoins, l’arsenal thérapeutique reste limité et le recours à une intervention chirurgicale demeure souvent inévitable pour les formes les plus graves. Au cours de ces dernières années, les polysaccharides (PS) ont suscité un intérêt majeur pour leur capacité à moduler l’inflammation intestinale et à espacer les périodes de crises. Leur association avec des substances actives a ouvert de nouvelles perspectives pour la recherche de traitements innovants et ciblés contre les MICI. Dans ce contexte, l’objectif général du présent travail de thèse a été de développer une forme médicamenteuse polysaccharidique d’un candidat-médicament pro-résolutif en vue de favoriser la guérison et cicatrisation locale des tissus intestinaux endommagés. La première partie de cette thèse a été consacrée au développement d’un nouvel outil préclinique in vitro destiné à étudier les effets des excipients bioactifs sur l’inflammation intestinale. La seconde partie a consisté à identifier des composés PS présentant une activité anti-inflammatoire en vue de les inclure dans la future formulation médicamenteuse. La troisième partie a porté sur la conception et l'évaluation, in vitro et in vivo, de la forme finale du candidat-médicament. Ces résultats ont mis en évidence le potentiel de l’hypromellose (HPMC) en tant qu’excipient bioactif et son effet additif anti-inflammatoire dans l’activité biologique du candidat-médicament. Bien que des investigations ultérieures soient nécessaires pour mieux comprendre son mécanisme d’action, l’ensemble de ces travaux souligne l’intérêt de l’HPMC en tant que médicament potentiel ou adjuvant dans la prévention et le traitement des MICIInflammatory bowel diseases (IBD) are gastrointestinal tract pathologies characterized by recurrent episodes of inflammation with periods of remission, and symptoms that negatively affect patients’ quality of life. Treatment of these complex diseases currently relies mainly on the oral administration of chemical molecules. Nevertheless, the therapeutic arsenal remains limited, and surgical intervention often remains inevitable for the most severe forms. In recent years, polysaccharides (PS) have aroused major interest for their ability to modulate intestinal inflammation and extend the crisis-free periods. Their combination with active substances has opened new prospects for the development of innovative and targeted treatments for IBD. In this context, the overall objective of the present thesis was to develop a PS-based medical form of a pro-resolving drug candidate to promote the healing and local tissue repair of damaged intestinal tissues. The first part of this thesis was devoted to the development of a new in vitro preclinical tool designed to study the effects of bioactive excipients on intestinal inflammation. The second part involved identifying PS compounds with anti-inflammatory activity for inclusion in the future drug formulation. The third focuses on the design and evaluation, in vitro and in vivo, of the final form of the drug candidate. These results highlighted the potential of hypromellose (HPMC) as bioactive excipient and its additive anti-inflammatory effect in the biological activity of the drug candidate. Although further investigations are required to better understand its mechanism of action, all this work underlines the interest of HPMC as a potential drug or adjuvant in the prevention and treatment of IBD
Частини книг з теми "Pro-Resolving factors":
1
Chukwudi, Onuoha F., and Okafor Joachim Chukwuma. "State Violence, Separatist Agitations, and Population Displacement in Cameroon." In Globalization and Its Impact on Violence Against Vulnerable Groups, 165–93. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-5225-9627-1.ch008.
Анотація:
This chapter interrogates the impacts of state violence and the proliferations of pro-separatist agitations in the Anglophone regions of Cameroon on vulnerable groups as its objective. Through secondary sources of data collection and content analysis, authors observed that the continued interplay of state violence and the various agitations for the independence of Ambazonia by separatist groups accounts for the ongoing displacement of women and children both as internally displaced persons and refugees. Hence, they argued that the unprecedented humanitarian challenges facing these vulnerable groups manifest in the various spheres of confrontations involving the Cameroonian security forces and various armed separatist groups in Southern Cameroon. Tables in this chapter provide links between how various dimensions of the Anglophone crisis affect women and children. This chapter discusses also the factors fuelling separatist agitations, future research directions, solutions and recommendations in resolving the Anglophone crisis in the Republique du la Cameroun.
2
Chukwudi, Onuoha F., and Okafor Joachim Chukwuma. "State Violence, Separatist Agitations, and Population Displacement in Cameroon." In Research Anthology on Modern Violence and Its Impact on Society, 311–31. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-7464-8.ch017.
Анотація:
This chapter interrogates the impacts of state violence and the proliferations of pro-separatist agitations in the Anglophone regions of Cameroon on vulnerable groups as its objective. Through secondary sources of data collection and content analysis, authors observed that the continued interplay of state violence and the various agitations for the independence of Ambazonia by separatist groups accounts for the ongoing displacement of women and children both as internally displaced persons and refugees. Hence, they argued that the unprecedented humanitarian challenges facing these vulnerable groups manifest in the various spheres of confrontations involving the Cameroonian security forces and various armed separatist groups in Southern Cameroon. Tables in this chapter provide links between how various dimensions of the Anglophone crisis affect women and children. This chapter discusses also the factors fuelling separatist agitations, future research directions, solutions and recommendations in resolving the Anglophone crisis in the Republique du la Cameroun.
3
Liu, Wenbin, and Guangwen Cao. "Hepatitis B Virus (HBV) - Induced Hepatocarcinogenesis, a Founding Framework of Cancer Evolution & Development (Cancer Evo-Dev)." In Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99838.
Анотація:
In this chapter, we present the founding framework of a novel theory termed as Cancer Evolution-Development (Cancer Evo-Dev), based on the current understanding of hepatitis B virus (HBV) induced hepatocarcinogenesis. The interactions of genetic predispositions and HBV infection is responsible for the maintenance of chronic non-resolving inflammation. Under the inflammatory microenvironment, pro-inflammatory factors trans-activate the expression of cytidine deaminases and suppress the expression of uracil DNA glycosylase. The imbalance between the mutagenic forces and mutation-correcting forces facilitates the generations of somatic mutations, viral mutations, and viral integrations into the host genomes. The majority of cells with genomic mutations and mutated viruses are eliminated in survival competition. Only a small percentage of the mutated cells adapted to the hostile environment can survive, retro-differentiate, and function as cancer-initiating cells, representing a process of “mutation-selection-adaptation”. Cancer Evo-Dev lays the theoretical foundation for understanding the mechanisms by which chronic infection of HBV promotes hepatocarcinogenesis. This theory also plays an important role in specific prophylaxis, prediction, early diagnosis, and targeted treatment of cancers.
Тези доповідей конференцій з теми "Pro-Resolving factors":
1
Singh, K. P., G. Lawyer, T. Muthumalage, N. A. Khan, S. R. McDonough, D. Ye, K. P. Maremanda, S. McIntosh, and I. Rahman. "Biomarkers of Inflammation, Oxidative Stress, Pro-Resolving Lipid Mediators, Triglycerides, Growth Factors and Tissue Injury in Electronic Cigarette Users: Implications for Non-Invasive Assessment of Vaping Associated Lung Injuries." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1225.