Статті в журналах з теми "Pressure on tissue"

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1

Lu, Y., K. H. Parker, and W. Wang. "Effects of osmotic pressure in the extracellular matrix on tissue deformation." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 364, no. 1843 (April 18, 2006): 1407–22. http://dx.doi.org/10.1098/rsta.2006.1778.

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In soft tissues, large molecules such as proteoglycans trapped in the extracellular matrix (ECM) generate high levels of osmotic pressure to counter-balance external pressures. The semi-permeable matrix and fixed negative charges on these molecules serve to promote the swelling of tissues when there is an imbalance of molecular concentrations. Structural molecules, such as collagen fibres, form a network of stretch-resistant matrix, which prevents tissue from over-swelling and keeps tissue integrity. However, collagen makes little contribution to load bearing; the osmotic pressure in the ECM is the main contributor balancing external pressures. Although there have been a number of studies on tissue deformation, there is no rigorous analysis focusing on the contribution of the osmotic pressure in the ECM on the viscoelastic behaviour of soft tissues. Furthermore, most previous works were carried out based on the assumption of infinitesimal deformation, whereas tissue deformation is finite under physiological conditions. In the current study, a simplified mathematical model is proposed. Analytic solutions for solute distribution in the ECM and the free-moving boundary were derived by solving integro-differential equations under constant and dynamic loading conditions. Osmotic pressure in the ECM is found to contribute significantly to the viscoelastic characteristics of soft tissues during their deformation.
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2

Adair, T. H., and A. C. Guyton. "Measurement of subcutaneous tissue fluid pressure using a skin-cup method." Journal of Applied Physiology 58, no. 5 (May 1, 1985): 1528–35. http://dx.doi.org/10.1152/jappl.1985.58.5.1528.

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We developed a new method for measuring tissue fluid pressure in subcutaneous tissue. Porous Teflon cylinders were permanently implanted subcutaneously into the inguinal area of 10 dogs, and after several weeks a skin concavity formed in the center of each of the cylinders. A small needle attached to a recording system was inserted into the free tissue fluid lining the concavity, and the tissue fluid pressure averaged -8.8 +/- 2.7 (SD) mmHg. Next, a hollow Plexiglas cup was placed over the concavity and glued to the skin. The air pressure in the skin cup was continually adjusted (using an electromechanical servo-control system) to pull the skin upward and to hold it perfectly flat across the upper ridge of the Teflon cylinder. The simultaneously recorded needle and cup pressures averaged -9.1 +/- 2.4 and -8.6 +/- 2.6 mmHg, respectively, during steady-state conditions with the skin in a flat position. Both pressures also responded appropriately to dynamic changes in tissue fluid pressure caused by increasing and decreasing the volume of the free tissue fluid. Because the skin was flat, the equivalences of pressures above and below the skin is consistent with the hypothesis that the skin was not tethered significantly to the underlying tissues and that cup pressure accurately estimates the tissue free fluid pressure.
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3

Klotz, Theodor, Roland Vorreuther, Axel Heidenreich, Jurgen Zumbe, and Udo Engelmann. "Testicular Tissue Oxygen Pressure." Journal of Urology 155, no. 4 (April 1996): 1488–91. http://dx.doi.org/10.1016/s0022-5347(01)66312-2.

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4

Preston, Ave, Aditi Rao, Robyn Strauss, Rebecca Stamm, and Demetra Zalman. "Deep Tissue Pressure Injury." AJN, American Journal of Nursing 117, no. 5 (May 2017): 50–57. http://dx.doi.org/10.1097/01.naj.0000516273.66604.c7.

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5

Drucker, W., F. Pearce, L. Glass-Heidenreich, H. Hopf, C. Powell, M. G. Ochsner, H. Frankel, et al. "Subcutaneous Tissue Oxygen Pressure." Journal of Trauma: Injury, Infection, and Critical Care 40, Supplement (March 1996): 116S—122S. http://dx.doi.org/10.1097/00005373-199603001-00026.

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6

Black, Joyce M., and Christine T. Berke. "Deep Tissue Pressure Injuries." Critical Care Nursing Clinics of North America 32, no. 4 (December 2020): 563–72. http://dx.doi.org/10.1016/j.cnc.2020.08.006.

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7

Allen, D., R. J. Korthuis, and S. Clark. "Evaluation of Starling forces in the equine digit." Journal of Applied Physiology 64, no. 4 (April 1, 1988): 1580–83. http://dx.doi.org/10.1152/jappl.1988.64.4.1580.

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A pump-perfused extracorporeal digital preparation was used to evaluate blood flow, arterial pressure, venous pressure, isogravimetric capillary filtration coefficient, capillary pressure, and vascular compliance in six normal horses. From these data, pre- and postcapillary resistances and pre- and postcapillary resistance ratios were determined. Vascular and tissue oncotic pressures were estimated from plasma and lymph protein concentrations, respectively. By use of the collected and calculated data, tissue pressure in the digit was calculated using the Starling equation. In the isolated equine digit, isogravimetric capillary pressure averaged 36.7 mmHg, plasma and lymph oncotic pressures averaged aged 19.12 and 6.6 mmHg, respectively, interstitial fluid pressure averaged 25.6 mmHg, and the capillary filtration coefficient averaged 0.0013 ml.min-1.mm-1.100 g-1. Our results indicate that digital capillary pressure in the laterally recumbent horse is much higher than in analogous tissues in other species such as dog and human. However, the potential edemagenic effects of this high digital capillary pressure are opposed by at least two mechanisms: 1) a high tissue pressure and 2) a low microvascular surface area for fluid exchange and/or a low microvascular permeability to filtered fluid.
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8

Harrel, Stephen K., Celeste M. Abraham, and Francisco Rivera-Hidalgo. "Tissue Resistance to Soft Tissue Emphysema during Minimally Invasive Periodontal Surgery." Journal of Contemporary Dental Practice 13, no. 6 (2012): 886–91. http://dx.doi.org/10.5005/jp-journals-10024-1247.

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ABSTRACT Aim The aim of this study was to determine the pressure where oral soft tissue resistance will be overcome resulting in soft tissue emphysema and to measure the safety of an antifouling device for a videoscope used during minimally invasive periodontal surgery. Materials and methods Resistance was measured in vitro in porcine tissue. One study arm measured palatal tissue resistance to air applied through a needle. Another arm measured resistance in a surgical access for minimally invasive periodontal surgery (MIS). India ink was placed on the tissue, pressure at 0,3,10,15,20, and 25 pounds/square inch (psi) applied, and penetration of India ink into the tissue was measured. Three trials in three sites were performed at each pressure in both arms of the study. Results Pressure applied to palatal tissue through a needle showed no significant penetration of India ink until 15 psi (0.90 ¡Ó 0.24 mm, p = 0.008). Penetration considered clinically significant was noted at 20 and 25 psi (4 to 6 mm, p „T 0.0001). No significant penetration was noted in minimally invasive incisions. Conclusion Within the test system, pressures of 15 psi or less seem unlikely to cause soft tissue emphysema. No evidence of tissue emphysema was noted with the videoscope antifouling device. Clinical significance The use of pressures greater than 15 pounds per square inch should be avoided during surgical procedures. The antifouling device for a videoscope appears safe for use during minimally invasive periodontal surgery. How to cite this article Harrel SK, Abraham CM, Rivera- Hidalgo F. Tissue Resistance to Soft Tissue Emphysema during Minimally Invasive Periodontal Surgery. J Contemp Dent Pract 2012;13(6):886-891.
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9

Wong, Patrick T. T., Rita K. Wong, and Michael Fung Kee Fung. "Pressure-Tuning FT-IR Study of Human Cervical Tissues." Applied Spectroscopy 47, no. 7 (July 1993): 1058–63. http://dx.doi.org/10.1366/0003702934415291.

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Infrared spectra of the normal connective, the normal epithelial, and the malignant epithelial tissues of cervix from seven patients have been measured as a function of pressure. Extremely high quality spectra of these tissue samples have been obtained. Consequently, structural differences at the molecular level among these three types of cervical tissues have been extracted from their pressure-tuning infrared spectra in the regions of the symmetric and antisymmetric stretching modes of phosphodiester groups, the C-O stretching mode, the CH2 bending mode, and the amide I mode. Significant differences in many features between the infrared spectra of the normal and the malignant cervical tissues and cells suggest that the infrared spectra of exfoliated cells and the biopsy of cervical tissues may be used in rapid evaluation of cervical cancer or in screening of large-volume normal cervical specimens. The infrared spectrum of the normal connective tissue of cervix in the frequency region 950 to 1100 cm−1 is similar to that of the malignant cervical tissue and cells. Therefore, if only this region of the spectrum is examined, the normal connective tissue will be misinterpreted as malignant tissue. However, the normal connective tissue can be differentiated unambiguously from the malignant tissue or the normal epithelial tissue by the infrared spectra in the frequency region 1200 to 1500 cm−1, where several well-defined sharp bands are unique for the normal connective tissue.
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10

Helili, Maimaitirexiati, Xiang Geng, Xin Ma, Wenming Chen, Chao Zhang, Jiazhang Huang, and Xu Wang. "An Investigation of Regional Plantar Soft Tissue Hardness and Its Potential Correlation with Plantar Pressure Distribution in Healthy Adults." Applied Bionics and Biomechanics 2021 (June 12, 2021): 1–9. http://dx.doi.org/10.1155/2021/5566036.

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Background. The plantar soft tissue plays a critical role in absorbing shocks and attenuating excessive stresses during walking. Plantar soft tissue property and plantar pressure are critical information for footwear design and clinical assessment. The aim of this study was to investigate the relationship between plantar soft tissue hardness and plantar pressure during walking. Methods. 59 healthy volunteers (27 males and 32 females, aged 20 to 82) participated in this study. The plantar surface was divided into five regions: lateral rearfoot, medial rearfoot, lateral midfoot, lateral forefoot, and medial forefoot, and the plantar tissue hardness was tested using Shore durometer in each region. Average dynamic pressures in each region were analyzed for the five regions corresponding to the hardness tests. The relationship between hardness and average dynamic pressure was analyzed in each region. Results. The average hardness of the plantar soft tissue in the above five regions is as follows: lateral rearfoot ( 34.49 ± 6.77 ), medial rearfoot ( 34.47 ± 6.64 ), lateral midfoot ( 27.95 ± 6.13 ), lateral forefoot ( 29.72 ± 5.47 ), and medial forefoot ( 28.58 ± 4.41 ). Differences of hardness were observed between age groups, and hardness of plantar soft tissues in forefoot regions increased with age ( P < 0.05 ). A negative relationship was found between plantar soft tissue hardness and pressure reduction at lateral rearfoot, medial rearfoot, and lateral midfoot ( P < 0.05 ). Conclusion. The hardness of plantar soft tissues changes with age in healthy individuals, and there is a trend of increasing hardness of the plantar soft tissue with age. The plantar soft tissue hardness increases with plantar pressure.
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11

Roberts, Denise. "Tissue viability: topical negative pressure." British Journal of Healthcare Assistants 1, no. 9 (December 2007): 395–98. http://dx.doi.org/10.12968/bjha.2007.1.9.27802.

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12

Heyeraas, K. J. "Pulpal, Microvascular, and Tissue Pressure." Journal of Dental Research 64, no. 4 (April 1985): 585–89. http://dx.doi.org/10.1177/002203458506400414.

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13

Panagoda, Prasan, and Daniel Horner. "Facial pressure induced tissue necrosis." Anaesthesia Cases 4, no. 1 (January 2016): 76–78. http://dx.doi.org/10.21466/ac.fpitn2.2016.

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14

Soppi, Esa, Juhani Knuuti, and Kari Kalliokoski. "Positron emission tomography study of effects of two pressure-relieving support surfaces on pressure ulcer development." Journal of Wound Care 30, no. 1 (January 2, 2021): 54–62. http://dx.doi.org/10.12968/jowc.2021.30.1.54.

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Objective: To study the pathophysiological cascade of pressure ulcer (PU) development consisting of tissue deformation, inflammation and hypoxia. Method: In this crossover study, deformation was measured with computerised tomography (CT) linked with contact area reflecting immersion and envelopment. Inflammation and hypoxia were measured using subepidermal moisture (SEM), skin temperature and tissue perfusion with positron emission tomography. These variables were investigated under 90 minutes of pressure exposure caused by two functionally different support surfaces—a regular foam mattress and a minimum pressure air (MPA) mattress. Results: A total of eight healthy volunteers took part in the study. There was major tissue deformation when the participants lay on a foam mattress while the tissues retained their original shape on the MPA mattress (p<0.0001). During the pressure exposure, the skin temperature increased significantly on both support surfaces but the final temperature on the foam mattress was about 1oC higher than on the MPA mattress (p<0.0001). SEM increased on both support surfaces compared with an unexposed reference site, but the cause may be different between the two support surfaces. Tissue perfusion was lowest in the skin followed by subcutaneous tissues and highest in the muscles. The pressure exposure did not cause any substantial changes in perfusion. The results showed that tissue deformation was more pronounced, the support surface contact area (envelopment), was smaller and the skin temperature higher on the foam mattress than on the MPA mattress, without significant differences in tissue perfusion. Conclusion: In this study, the MPA mattress support surface had mechanobiological properties that counteracted tissue deformation and thereby may prevent PUs.
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15

Kang, Jin-Wha, Guan-Liang Chang, and You-Li Chou. "Study on surface and tissue pressures related to pressure sore." Journal of Biomechanics 25, no. 7 (July 1992): 801. http://dx.doi.org/10.1016/0021-9290(92)90551-b.

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16

Adair, T. H., G. A. Vance, J. P. Montani, and A. C. Guyton. "Effect of skin concavity on subcutaneous tissue fluid pressure." American Journal of Physiology-Heart and Circulatory Physiology 261, no. 2 (August 1, 1991): H349—H353. http://dx.doi.org/10.1152/ajpheart.1991.261.2.h349.

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We tested the hypothesis that mechanical factors associated, with a skin concavity can cause the local tissue fluid pressure to become more negative. Perforated Teflon collars, 26 mm in diameter and having various heights (5, 10, 13, and 16 mm), were implanted into the fascial plane of the inguinal and abdominal areas of six sheep. After several weeks, visible signs of edema were no longer apparent, and the skin formed a concavity within the center of each collar. The depth of each concavity was measured using an electronic micrometer, and the tissue fluid pressure beneath the concavity was measured using a needle method. Over the entire range of collar heights, the average depth of the concavities ranged from 1.1 to 4.7 mm in the abdominal tissues and from 1.8 to 5.5 mm in the inguinal tissues. The respective values of tissue fluid pressure averaged -4.6 to -13.0 and -5.7 to -12.8 mmHg. The results therefore indicate that implanting deeper collars leads to the formation of deeper concavities in the skin and also to greater negativity in the free tissue fluid pressure beneath the skin. Linear regression extrapolation to a collar height of 0 mm corresponded to a tissue fluid pressure of -1.0 mmHg in the abdominal tissue and -2.4 mmHg in the inguinal tissues. A model based on excessive pumping of the lymphatic system in the vicinity of a concavity is provided to explain this newly described phenomenon. We conclude that mechanical factors associated with the formation of a skin concavity cause or permit the tissue fluid pressure to reach levels of negativity far greater than those that exist in the absence of a concavity.
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17

Reed, RK, K. Woie, and K. Rubin. "Integrins and Control of Interstitial Fluid Pressure." Physiology 12, no. 1 (February 1, 1997): 42–49. http://dx.doi.org/10.1152/physiologyonline.1997.12.1.42.

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The present review summarizes recent information on the physiology of connective tissues, in particular, control of interstitial fluid pressure (Pif) and, thereby, interstitial volume. A combination of classic physiological techniques and techniques from cellular and molecular biology have provided new insights into control of Pif by connective tissue cells and the adhesion receptors anchoring them to structural connective tissue components.
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18

Uesugi, Kaoru, Fumiaki Shima, Ken Fukumoto, Ayami Hiura, Yoshinari Tsukamoto, Shigeru Miyagawa, Yoshiki Sawa, Takami Akagi, Mitsuru Akashi, and Keisuke Morishima. "Micro Vacuum Chuck and Tensile Test System for Bio-Mechanical Evaluation of 3D Tissue Constructed of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPS-CM)." Micromachines 10, no. 7 (July 19, 2019): 487. http://dx.doi.org/10.3390/mi10070487.

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In this report, we propose a micro vacuum chuck (MVC) which can connect three-dimensional (3D) tissues to a tensile test system by vacuum pressure. Because the MVC fixes the 3D tissue by vacuum pressure generated on multiple vacuum holes, it is expected that the MVC can fix 3D tissue to the system easily and mitigate the damage which can happen by handling during fixing. In order to decide optimum conditions for the size of the vacuum holes and the vacuum pressure, various sized vacuum holes and vacuum pressures were applied to a normal human cardiac fibroblast 3D tissue. From the results, we confirmed that a square shape with 100 µm sides was better for fixing the 3D tissue. Then we mounted our developed MVCs on a specially developed tensile test system and measured the bio-mechanical property (beating force) of cardiac 3D tissue which was constructed of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM); the 3D tissue had been assembled by the layer-by-layer (LbL) method. We measured the beating force of the cardiac 3D tissue and confirmed the measured force followed the Frank-Starling relationship. This indicates that the beating property of cardiac 3D tissue obtained by the LbL method was close to that of native cardiac tissue.
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19

Rööser, Bo, Anders Rydholm, and Björn M. Persson. "Internal pressure in soft-tissue tumors." Acta Orthopaedica Scandinavica 57, no. 5 (January 1986): 444–46. http://dx.doi.org/10.3109/17453678609014768.

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20

Harwood, Judith K. "BED FRAMES AND TISSUE INTERFACE PRESSURE." Journal of Wound, Ostomy and Continence Nursing 32 (May 2005): S28—S29. http://dx.doi.org/10.1097/00152192-200505002-00094.

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21

Grisell, Margaret, and Howard M. Place. "Face Tissue Pressure in Prone Positioning." Spine 33, no. 26 (December 2008): 2938–41. http://dx.doi.org/10.1097/brs.0b013e31818b9029.

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22

CHANT, A. "Tissue pressure, posture, and venous ulceration." Lancet 336, no. 8722 (October 1990): 1050–51. http://dx.doi.org/10.1016/0140-6736(90)92503-a.

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23

Oomens, Cees W. J., Daniel L. Bader, Sandra Loerakker, and Frank Baaijens. "Pressure Induced Deep Tissue Injury Explained." Annals of Biomedical Engineering 43, no. 2 (December 6, 2014): 297–305. http://dx.doi.org/10.1007/s10439-014-1202-6.

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24

Scott, H. J., and P. D. Coleridge Smith. "Tissue pressure, posture, and venous ulceration." Lancet 336, no. 8730-8731 (December 1990): 1585. http://dx.doi.org/10.1016/0140-6736(90)93363-t.

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25

Chant, A. D. B. "Tissue pressure, posture, and venous ulceration." Lancet 337, no. 8737 (February 1991): 378. http://dx.doi.org/10.1016/0140-6736(91)91025-p.

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26

Kinzer-Ursem, Tamara. "Relieving the Pressure on Tissue Development." Biophysical Journal 113, no. 2 (July 2017): 360–61. http://dx.doi.org/10.1016/j.bpj.2017.06.006.

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27

Wise, Eric S., Kyle M. Hocking, Brian C. Evans, Craig L. Duvall, Joyce Cheung-Flynn, and Colleen M. Brophy. "Unregulated saphenous vein graft distension decreases tissue viscoelasticity." Perfusion 32, no. 6 (March 9, 2017): 489–94. http://dx.doi.org/10.1177/0267659117697814.

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Objectives: Unregulated intraoperative distension of human saphenous vein (SV) graft leads to supraphysiologic luminal pressures and causes acute physiologic and cellular injury to the conduit. The effect of distension on tissue viscoelasticity, a biophysical property critical to a successful graft, is not well described. In this investigation, we quantify the loss of viscoelasticity in SV deformed by distension and compare the results to tissue distended in a pressure-controlled fashion. Materials and Methods: Unmanipulated porcine SV was used as a control or distended without regulation and distended with an in-line pressure release valve (PRV). Rings were cut from these tissues and suspended on a muscle bath. Force versus time tracings of tissue constricted with KCl (110 mM) and relaxed with sodium nitroprusside (SNP) were fit to the Hill model of viscoelasticity, using mean absolute error (MAE) and r2-goodness of fit as measures of conformity. Results: One-way ANOVA analysis demonstrated that, in tissue distended manually, the MAE was significantly greater and the r2-goodness of fit was significantly lower than both undistended tissues and tissues distended with a PRV (p<0.05) in KCl-induced vasoconstriction and SNP-induced vasodilation. Conclusions: Unregulated manual distension of SV graft causes loss of viscoelasticity and such loss may be mitigated with the use of an in-line PRV.
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28

Abouaesha, Frag, Carine H. M. van Schie, David G. Armstrong, and Andrew J. M. Boulton. "Plantar Soft-Tissue Thickness Predicts High Peak Plantar Pressure in the Diabetic Foot." Journal of the American Podiatric Medical Association 94, no. 1 (January 1, 2004): 39–42. http://dx.doi.org/10.7547/87507315-94-1-39.

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The aim of this study was to evaluate whether high plantar foot pressures can be predicted from measurements of plantar soft-tissue thickness in the forefoot of diabetic patients with neuropathy. A total of 157 diabetic patients with neuropathy and at least one palpable foot pulse but without a history of foot ulceration were invited to participate in the study. Plantar tissue thickness was measured bilaterally at each metatarsal head, with patients standing on the same standardized platform. Plantar pressures were measured during barefoot walking using the optical pedobarograph. Receiver operating characteristic analysis was used to determine the plantar tissue thickness predictive of elevated peak plantar pressure. Tissue thickness cutoff values of 11.05, 7.85, 6.65, 6.55, and 5.05 mm for metatarsal heads 1 through 5, respectively, predict plantar pressure at each respective site greater than 700 kPa, with sensitivity between 73% and 97% and specificity between 52% and 84%. When tissue thickness was used to predict pressure greater than 1,000 kPa, similar results were observed, indicating that high pressure at different levels could be predicted from similar tissue thickness cutoff values. The results of the study indicate that high plantar pressure can be predicted from plantar tissue thickness with high sensitivity and specificity. (J Am Podiatr Med Assoc 94(1): 39-42, 2004)
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29

Ursino, Mauro, and Cristina Cristalli. "Mathematical Modeling of Noninvasive Blood Pressure Estimation Techniques—Part I: Pressure Transmission Across the Arm Tissue." Journal of Biomechanical Engineering 117, no. 1 (February 1, 1995): 107–16. http://dx.doi.org/10.1115/1.2792258.

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A mathematical model of the arm tissue mechanical behavior under the effect of external pressure loads is presented. The model has been used to study stress and strain distribution across the tissue, and pressure transmission to the brachial artery, when the arm is compressed by two adjacent cuffs independently inflated. Using this configuration, the tissue elastic parameters (Young modulus and Poisson ratio) can be individually identified using a simple and noninvasive experimental procedure. Model validation has been achieved by comparing its results with data obtained experimentally on 10 subjects. These comparisons demonstrate that the proposed model may constitute a simple but valid new tool able to describe tissue behavior, subjected to external pressures, with sufficient accuracy. Joined with a model of brachial hemodynamics, it might contribute to improve our understanding of noninvasive blood pressure estimation techniques.
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30

Wolfla, Christopher E., Thomas G. Luerssen, Robin M. Bowman, and Timothy K. Putty. "Brain tissue pressure gradients created by expanding frontal epidural mass lesion." Journal of Neurosurgery 84, no. 4 (April 1996): 642–47. http://dx.doi.org/10.3171/jns.1996.84.4.0642.

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✓ A porcine model was used to study the regional intracranial pressure (ICP) differences caused by a frontal mass lesion. Intraparenchymal ICP monitors were placed in the right and left frontal lobes, right and left temporal lobes, midbrain, and cerebellum. A frontal epidural mass lesion was created by placing a balloon catheter through a burr hole into the right frontal epidural space. A computer was used to acquire data from all monitors at 50-msec intervals. The balloon was expanded by 1 cc over a period of 1 second every 5 minutes and maximum pressure immediately before and during expansion was determined for each balloon volume at each site. Prior to expansion of the mass, the morphology of the cerebellum pressure tracing was different from that seen in all supratentorial regions. Also, pressures in the midbrain, at baseline, were slightly but significantly lower than pressures in the frontal and temporal regions. During expansion of the mass, a pressure differential that increased as the size of the mass increased developed between intracranial regions. Furthermore, the regional pressures were found to vary in a consistent fashion expressed by the formula RF = LF > RT = LT > MB > CB, in which RF and LF are the right and left frontal lobes, RT and LT are the right and left temporal lobes, MR is the midbrain, and CB is the cerebellum. The study shows that an expanding epidural mass reproducibly results in a gradient of brain parenchymal pressure. This gradient results in parenchymal pressures that are significantly different in each region of the brain depending on the proximity of that region to the epidural mass. The results of this study have implications for clinical ICP monitoring and therapy.
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31

Punantapong, Boonyong. "Deformation of the Extracellular Matrix Due to Osmotic Pressure in Cartilaginous Tissues." Advanced Materials Research 93-94 (January 2010): 243–46. http://dx.doi.org/10.4028/www.scientific.net/amr.93-94.243.

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This study is to characterize and estimate preferential flow and solute transport in soft tissue. In soft tissues, large molecules such as proteoglycans trapped in the extracellular matrix generate high levels of osmotic pressure to counter balance external pressures. The semi-permeable matrix and fixed negative charges on these molecules serve to promote the swelling and collapse behaviour of cartilaginous tissues when there is an imbalance of molecular concentrations. At the same time, the collagen fibres were a network of stretch-resistant matrix, which prevents tissue from over-swelling and keeps tissue integrity. Therefore, a simplified mathematical model is proposed, and implemented in the finite element method. Analytic solutions for solute distribution in the extracellular matrix were derived by solving under loading conditions. The results were found that the estimate with field fluctuations led to the numerical results in most cases, and significant differences were only found under conditions of highly constrained deformation.
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32

Hoffman, William E., Fady T. Charbel, Guy Edelman, Kelly Hannigan, and James I. Ausman. "Brain tissue oxygen pressure, carbon dioxide pressure and pH during ischemia." Neurological Research 18, no. 1 (February 1996): 54–56. http://dx.doi.org/10.1080/01616412.1996.11740378.

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33

Soehle, M., M. Jaeger, M. U. Schuhmann, and J. Meixensberger. "Correlation between cerebral pressure autoregulation and brain tissue oxygenation-pressure-reactivity." European Journal of Anaesthesiology 22, Supplement 34 (May 2005): 88–89. http://dx.doi.org/10.1097/00003643-200505001-00313.

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34

Kishida, Akio, Seiichi Funamoto, Jun Negishi, Yoshihide Hashimoto, Kwangoo Nam, Tsuyoshi Kimura, Toshiya Fujisato, and Hisatoshi Kobayashi. "Tissue Engineering with Natural Tissue Matrices." Advances in Science and Technology 76 (October 2010): 125–32. http://dx.doi.org/10.4028/www.scientific.net/ast.76.125.

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Natural tissue, especially autologous tissue is one of ideal materials for tissue regeneration. Decellularized tissue could be assumed as a second choice because the structure and the mechanical properties are well maintained. Decellularized human tissues, for instance, heart valve, blood vessel, and corium, have already been developed and applied clinically. Nowadays, decellularized porcine tissues are also investigated. These decellularized tissues were prepared by detergent treatment. The detergent washing is easy but sometime it has problems. We have developed the novel decellularization method, which applied the high-hydrostatic pressure (HHP). As the tissue set in the pressurizing chamber is treated uniformly, the effect of the high-hydrostatic pressurization does not depend on the size of tissue. We have reported the HHP decellularization of heart valve, blood vessel, bone, and cornea. Furthermore, HHP treatments are reported to have the ability of the extinction of bacillus and the inactivation of virus. So, the HHP treatment is also expected as the sterilization method. We are investigating efficient processes of decellularization and recellularization of biological tissues to have bioscaffolds keeping intact structure and biomechanical properties. Our recent studies on tissue engineering using HHP decellularized tissue will be reported here.
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35

Knops, Simon P., Marcel P. J. M. van Riel, Richard H. M. Goossens, Esther M. M. van Lieshout, Peter Patka, and Inger B. Schipper. "Measurements of the Exerted Pressure by Pelvic Circumferential Compression Devices." Open Orthopaedics Journal 4, no. 1 (February 17, 2010): 101–6. http://dx.doi.org/10.2174/1874325001004010101.

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Background: Data on the efficacy and safety of non-invasive Pelvic Circumferential Compression Devices (PCCDs) is limited. Tissue damage may occur if a continuous pressure on the skin exceeding 9.3 kPa is sustained for more than two or three hours. The aim of this study was to gain insight into the pressure build-up at the interface, by measuring the PCCD-induced pressure when applying pulling forces to three different PCCDs (Pelvic Binder®, SAM-Sling® and T-POD®) in a simplified model. Methods: The resulting exerted pressures were measured at four ‘anatomical’ locations (right, left, posterior and anterior) in a model using a pressure measurement system consisting of pressure cuffs. Results: The exerted pressure varied substantially between the locations as well as between the PCCDs. Maximum pressures ranged from 18.9-23.3 kPa and from 19.2-27.5 kPa at the right location and left location, respectively. Pressures at the posterior location stayed below 18 kPa. At the anterior location pressures varied markedly between the different PCCDs. Conclusion: The circmferential compression by the different PCCDs showed high pressures measured at the four locations using a simplified model. Difference in design and functional characteristics of the PCCDs resulted in different pressure build-up at the four locations. When following the manufacturer’s instructions, the exerted pressure of all three PCCDs tested exceeded the tissue damaging level (9.3 kPa). In case of prolonged use in a clinical situation this might put patients at risk for developing tissue damage.
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36

Doh, Gyeonghyeon, and Chan Yeong Heo. "Pathogenesis and prevention of pressure ulcer." Journal of the Korean Medical Association 64, no. 1 (January 10, 2021): 16–25. http://dx.doi.org/10.5124/jkma.2021.64.1.16.

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The number of pressure ulcer patients is increasing owing to the aging population and increased incidence of elderly illness. This review article aims to introduce the current knowledge on the pathogenesis and prevention of pressure ulcers. The development of a pressure ulcer is associated with external factors such as pressure, shear stress, and friction and internal factors such as age, general condition, skin condition, and nutritional status. Pressure ulcers typically develop over bone protrusions, which are most pressured by weight, but may also be caused by external pressure by medical devices or other objects applied to the patient. This tissue damage is caused by continuous deformation of the tissue due to the pressure acting perpendicular to the tissue surface and shear stress acting parallel to the tissue, either alone or in combination. Limitation of activity and mobility, skin condition, blood circulation and oxygen saturation, nutrition, humidity, body temperature, age, low pain sensitivity, blood count, and general and mental conditions are the primary risk factors for pressure ulcers. A mattress and cushion that reduce pressure and an appropriate posture are necessary to prevent pressure ulcers. In patients with urinary incontinence, contaminated skin should be washed with a mild detergent and absorbent pads and topical protective agents should be used to protect the skin from moisture. Sufficient nutrition may help prevent wounds in patients who are susceptible to pressure ulcers. Furthermore, early screening, individualized management of posture, and regular skin and nutrition monitoring are essential to prevent pressure ulcers.
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37

Iannotti, Fausto, Julian T. Hoff, and Gerald P. Schielke. "Brain tissue pressure in focal cerebral ischemia." Journal of Neurosurgery 62, no. 1 (January 1985): 83–89. http://dx.doi.org/10.3171/jns.1985.62.1.0083.

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✓ Twenty-three anesthetized cats underwent permanent middle cerebral artery occlusion in a study of the relationships of regional cerebral blood flow, ventricular fluid pressure, brain tissue pressure, and ischemic edema formation. A pressure gradient of 8 mm Hg developed between ischemic tissue and normally perfused tissue during a 4-hour observation period after occlusion. Brain water accumulated as tissue pressure rose, while blood flow in the same area fell. The data suggest, but do not prove, that ischemic brain edema causes tissue pressure to rise focally, and that blood flow to the ischemic zone is compromised further by the resultant hydrostatic pressure gradient.
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38

Lund, N., A. Bengtsson, and P. Thorborg. "Muscle Tissue Oxygen Pressure in Primary Fibromyalgia." Scandinavian Journal of Rheumatology 15, no. 2 (January 1986): 165–73. http://dx.doi.org/10.3109/03009748609102084.

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39

Studer, D., S. Zhao, W. Graber, P. Eggli, and M. Frotscher. "High Pressure Freezing of Brain Tissue Slices." Microscopy and Microanalysis 12, S02 (July 31, 2006): 100–101. http://dx.doi.org/10.1017/s1431927606061800.

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40

Johnsson, C., R. Hällgren, and G. Tufveson. "Hyaluronidase reduces intragraft pressure of rejecting tissue." Transplantation Proceedings 33, no. 4 (June 2001): 2484. http://dx.doi.org/10.1016/s0041-1345(01)02071-1.

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41

Black, Joyce. "Tissue Oxygen Perfusion and Pressure Ulcer Healing." Plastic Surgical Nursing 20, no. 1 (2000): 10–14. http://dx.doi.org/10.1097/00006527-200002010-00003.

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42

Schwartz, Alan R., Jason Kirkness, and Philip Smith. "Extraluminal tissue pressure: what does it mean?" Journal of Applied Physiology 100, no. 1 (January 2006): 5–6. http://dx.doi.org/10.1152/japplphysiol.01239.2005.

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43

Raychaudhuri, Urmimala, J. Cameron Millar, and Abbot F. Clark. "Tissue Transglutaminase Elevates Intraocular Pressure in Mice." Investigative Opthalmology & Visual Science 58, no. 14 (December 8, 2017): 6197. http://dx.doi.org/10.1167/iovs.17-22236.

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44

Dağ, Meral, and Muhittin Yürekli. "Investigation of angiogenic factors in obese rats exposed to low oxygen pressure." Medical Science and Discovery 7, no. 3 (March 21, 2020): 426–30. http://dx.doi.org/10.36472/msd.v7i3.360.

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Objective: Obesity, which is one of the most important health problems of today's people, remains current due to the risks of illness it brings due to the increase rate in the world. Material and Methods: Male Sprague Dawley rats were used in our study of obesity. Rats were divided into four groups as standard diet/ normal oxygen, standard diet/low oxygen, high-fat diet/normal oxygen and high-fat diet / low oxygen. For the study, a special cage with a low oxygen level of 17-18% was made in a closed system. After achieving the desired 25% weight increase in obese group rats, blood, liver, lung, white adipose tissue and brown adipose tissue were obtained from the rats. In these tissues, adrenomedullin, hypoxic inducible factor 1-α (HIF1-α) and matrix metalloproteinase-II (MMP-II) levels were measured by ELISA. Results: According to our results, there was a significant increase in adrenomedullin, HIF1-α and MMP-II in white adipose tissue, and adrenomedullin and MMP-II in brown adipose tissue. It was found that the amount of HIF1-α increased significantly in liver and lung tissues. Conclusion: According to the metabolic status of adipose tissue, it is thought that the effect of adrenomedullin, HIF1-α and MMP-II can increase vascularization of brown adipose tissue and provide energy consumption.
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45

Siu, Parco M., Eric W. Tam, Bee T. Teng, Xiao M. Pei, Joann W. Ng, Iris F. Benzie, and Arthur F. Mak. "Muscle apoptosis is induced in pressure-induced deep tissue injury." Journal of Applied Physiology 107, no. 4 (October 2009): 1266–75. http://dx.doi.org/10.1152/japplphysiol.90897.2008.

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Pressure ulcer is a complex and significant health problem. Although the factors including pressure, shear, and ischemia have been identified in the etiology of pressure ulcer, the cellular and molecular mechanisms that contribute to the development of pressure ulcer are unclear. This study tested the hypothesis that the early-onset molecular regulation of pressure ulcer involves apoptosis in muscle tissue. Adult Sprague-Dawley rats were subjected to an in vivo protocol to mimic pressure-induced deep tissue injury. Static pressure was applied to the tibialis region of the right limb of the rats for 6 h each day on two consecutive days. The compression force was continuously monitored by a three-axial force transducer equipped in the compression indentor. The contralateral uncompressed limb served as intra-animal control. Tissues underneath the compressed region were collected for histological analysis, terminal dUTP nick-end labeling (TUNEL), cell death ELISA, immunocytochemical staining, and real-time RT-PCR gene expression analysis. The compressed muscle tissue generally demonstrated degenerative characteristics. TUNEL/dystrophin labeling showed a significant increase in the apoptotic muscle-related nuclei, and cell death ELISA demonstrated a threefold elevation of apoptotic DNA fragmentation in the compressed muscle tissue relative to control. Positive immunoreactivities of cleaved caspase-3, Bax, and Bcl-2 were evident in compressed muscle. The mRNA contents of Bax, caspase-3, caspase-8, and caspase-9 were found to be higher in the compressed muscle tissue than control. These results demonstrated that apoptosis is activated in muscle tissue following prolonged moderate compression. The data are consistent with the hypothesis that muscle apoptosis is involved in the underlying mechanism of pressure-induced deep tissue injury.
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46

Thomas, David R. "Prevention and management of pressure ulcers." Reviews in Clinical Gerontology 11, no. 2 (May 2001): 115–30. http://dx.doi.org/10.1017/s0959259801011236.

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A pressure ulcer is the visible evidence of pathological changes in blood supply to the dermal and underlying tissues, usually due to compression of the tissue over a bony prominence. Pressure ulcers are one of several types of chronic ulcers of the skin, including venous stasis, diabetic ulcers, and arterial insufficiency ulcers. The differential diagnosis of pressure ulcers is imperative, since the management of each wound type differs substantially.
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47

Elder, Benjamin D., and Kyriacos A. Athanasiou. "Hydrostatic Pressure in Articular Cartilage Tissue Engineering: From Chondrocytes to Tissue Regeneration." Tissue Engineering Part B: Reviews 15, no. 1 (March 2009): 43–53. http://dx.doi.org/10.1089/ten.teb.2008.0435.

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48

Harvey, Martyn G. "Influence of tissue pressure on central venous pressure/peripheral venous pressure correlation: An experimental report." World Journal of Emergency Medicine 2, no. 2 (2011): 93. http://dx.doi.org/10.5847/wjem.j.1920-8642.2011.02.003.

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49

Rithalia, Shyam V. S., and Mahendra Gonsalkorale. "Quantification of pressure relief using interface pressure and tissue perfusion in alternating pressure air mattresses." Archives of Physical Medicine and Rehabilitation 81, no. 10 (October 2000): 1364–69. http://dx.doi.org/10.1053/apmr.2000.9164.

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50

Wong, Patrick T. T., Suzanne Lacelle, and Hossein M. Yazdi. "Normal and Malignant Human Colonic Tissues Investigated by Pressure-Tuning FT-IR Spectroscopy." Applied Spectroscopy 47, no. 11 (November 1993): 1830–36. http://dx.doi.org/10.1366/0003702934065885.

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Infrared spectra of the epithelial, the connective, the mucosa, and the malignant tissues of the human colon have been measured as a function of pressure. Infrared spectra of collagen proteins have also been measured and compared with the connective tissue. The infrared spectra of different types of colon tissues exhibit significantly different patterns. With these specific infrared patterns, the tissue types of the colon can be differentiated unambiguously. Many structural changes at the molecular level from normal epithelium to malignant tumor have been derived from the spectral features of these two related tissues. These structural changes in carcinogenesis of the colon are comparable with those in other human cancers. The present results suggest that determination of these infrared spectra may be applied to the rapid identification of normal tissue types of the colon and evaluation of colon cancer.
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