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1
Wang, Yan, Hao Feng, Yimin Zhang, Chendi Lin, Ligang Zheng, Wentao Ji, and Xuefeng Han. "Suppression Effects of Hydroxy Acid Modified Montmorillonite Powders on Methane Explosions." Energies 12, no. 21 (October 25, 2019): 4068. http://dx.doi.org/10.3390/en12214068.
Повний текст джерелаАнотація:
In this paper, montmorillonite inhibitors modified with polyhydroxy functional groups by gluconic acid (GA) were successfully prepared. The particle size distribution, composition, surface functional groups, and pyrolysis characteristics of the pure montmorillonite powders (Mt) and the gluconic acid modified powders (G-Mt) were analyzed by using a laser particle analyzer, X-ray diffraction (XRD), Fourier transform infrared (FTIR) and thermogravimetry–differential scanning calorimetry (TG-DSC), respectively. The suppression effect of Mt and G-Mt on the 9.5% methane–air premixed gas was tested in a 20 L spherical explosion device and a 5 L pipeline experimental system. The results show that G-Mt displays a much better suppression property than that of Mt. The optimal explosion suppression effect concentration of Mt or G-Mt powders is about 0.25 g·L−1. In this concentration, for G-Mt, the maximum explosion pressure declined by 26.7%, the maximum rate of pressure rise declined by 74.63%, and the time for the flame front to reach the top of the pipe was delayed by 242.5%. On the basis of the experimental data, the better suppression effect of G-Mt than Mt might be attributed to the presence of more hydroxyl groups on the surface.
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Fligor, Scott C., Mark E. Hamill, Katie M. Love, Bryan R. Collier, Dan Lollar, and Eric H. Bradburn. "Vital Signs Strongly Predict Massive Transfusion Need in Geriatric Trauma Patients." American Surgeon 82, no. 7 (July 2016): 632–36. http://dx.doi.org/10.1177/000313481608200730.
Повний текст джерелаАнотація:
Early recognition of massive transfusion (MT) requirement in geriatric trauma patients presents a challenge, as older patients present with vital signs outside of traditional thresholds for hypotension and tachycardia. Although many systems exist to predict MT need in trauma patients, none have specifically evaluated the geriatric population. We sought to evaluate the predictive value of presenting vital signs in geriatric trauma patients for prediction of MT. We retrospectively reviewed geriatric trauma patients presenting to our Level I trauma center from 2010 to 2013 requiring full trauma team activation. The area under the receiver operating characteristic curve was calculated to assess discrimination of arrival vital signs for MT prediction. Ideal cutoffs with high sensitivity and specificity were identified. A total of 194 patients with complete data were analyzed. Of these, 16 patients received MT. There was no difference between the MT and non-MT groups in sex, age, or mechanism. Systolic blood pressure, pulse pressure, diastolic blood pressure, and shock index all were strongly predictive of MT need. Interestingly, we found that heart rate does not predict MT. MT in geriatric trauma patients can be reliably and simply predicted by arrival vital signs. Heart rate may not reflect serious hemorrhage in this population.
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Yi, Sang-Bong, Mi Lee, Jong Lee, and Hwayoung Kim. "Timing and Metamorphic Evolution of the Ross Orogeny in and around the Mountaineer Range, Northern Victoria Land, Antarctica." Minerals 10, no. 10 (October 13, 2020): 908. http://dx.doi.org/10.3390/min10100908.
Повний текст джерелаАнотація:
The Ross(–Delamerian) Orogeny significantly impacted the formation of the tectonic structure of the Pacific Gondwana margin during the early Paleozoic era. Northern Victoria Land (NVL) in Antarctica preserves the aspect of the Ross Orogeny that led to the union of the Wilson (WT)–Bowers (BT)–Robertson Bay Terrane. The aspect of the Ross Orogeny in the NVL is characterized by subduction of oceanic domains toward the continental margin (continental arc) and the accretion of the associated marine–continental substances from 530–480 Ma. In the Mountaineer Range in NVL, the Ross Orogeny strain zone is identified at the WT/BT boundary regions. In these areas, fold and thrust shear zones are observed and aspects of them can be seen at Mt. Murchison, the Descent Unit and the Black Spider Greenschist zone. The Dessent Unit corresponds to a tectonic slice sheared between the WT and BT. The metamorphic evolution phase of the Dessent Unit is summarized in the peak pressure (M1), peak temperature (M2) and retrograde (M3). The sensitive high-resolution ion microprobe (SHRIMP) zircon U–Pb ages of 514.6 ± 2.0 Ma and 499.2 ± 3.4 Ma obtained from the Dessent Unit amphibolite are comparable to the M1 and M2 stages, respectively. The Dessent Unit underwent intermediate pressure (P)/temperature (T)-type metamorphism characterized by 10.0–10.5 kbar/~600 °C (M1) and ~7 kbar/~700 °C (M2) followed by 4.0–4.5 kbar/~450 °C (M3). Mafic to intermediate magmatism (497–501 Ma) within the WT/BT boundary region may have given rise to the M2 stage of the Dessent Unit, and this magmatism is synchronous with the migmatization period of Mt. Murchison (498.3 ± 3.4 Ma). This indicates that a continuous process of fold-shearing–magmatic intrusion–partial melting, which is typically associated with a continental arc orogeny, occurred before and after c. 500 Ma in the Mountaineer Range. During the Ross Orogeny, the Dessent unit was initially subducted underneath the WT at depth (10.0–10.5 kbar, ~35 km) and then thrust into the shallow (~7 kbar, ~23 km), hot (≥700 °C) magmatic arc docking with the Mt. Murchison terrain, where migmatization prevailed.
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Williams, Mark L., Andrew N. Drinnan, and Neville G. Walsh. "Variation within Prostanthera spinosa (Lamiaceae): evidence from morphological and molecular studies." Australian Systematic Botany 19, no. 5 (2006): 467. http://dx.doi.org/10.1071/sb05032.
Повний текст джерелаАнотація:
Specimens of Prostanthera spinosa F. Muell. representing the geographic range of the taxon were examined for morphological and genetic variation within the species. Patterns of morphological variation were documented and the amplified fragment length polymorphism (AFLP) DNA fingerprinting technique was used to assess the genetic relationships among plants from different populations. Morphological and molecular results were in broad agreement and supported distinct groups in both analyses. The differences detected warrant taxonomic recognition and three species are described representing geographically disjunct regions. Plants from the Grampians in Victoria, Eyre Peninsula, Flinders Ranges and Kangaroo Island in South Australia, group together and retain the name P. spinosa; plants from Mt Arapiles in Victoria are distinct and are recognised as a new species P. arapilensis; plants from the Fortis Creek National Park and adjacent areas in northern New South Wales are distinct and are identified as a new species, P. sejuncta.
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Goyal, Nitin, Georgios Tsivgoulis, Abhi Pandhi, Jason J. Chang, Kira Dillard, Muhammad Fawad Ishfaq, Katherine Nearing, et al. "Blood pressure levels post mechanical thrombectomy and outcomes in large vessel occlusion strokes." Neurology 89, no. 6 (July 7, 2017): 540–47. http://dx.doi.org/10.1212/wnl.0000000000004184.
Повний текст джерелаАнотація:
Objective:There are limited data evaluating the effect of post mechanical thrombectomy (MT) blood pressure (BP) levels on early outcomes of patients with large vessel occlusions (LVO). We sought to investigate the association of BP course following MT with early outcomes in LVO.Methods:Consecutive patients with LVO treated with MT during a 3-year period were evaluated. Hourly systolic BP (SBP) and diastolic BP (DBP) values were recorded for 24 hours following MT and maximum SBP and DBP levels were identified. LVO patients with complete reperfusion following MT were stratified in 3 groups based on post-MT achieved BP goals: <140/90 mm Hg (intensive), <160/90 mm Hg (moderate), and <220/110 mm Hg or <180/105 mm Hg when pretreated with IV thrombolysis (permissive hypertension). Three-month functional independence was defined as modified Rankin Scale score of 0–2.Results:A total of 217 acute ischemic stroke patients with LVO were prospectively evaluated. A 10 mm Hg increment in maximum SBP documented during the first 24 hours post MT was independently (p = 0.001) associated with a lower likelihood of 3-month functional independence (odds ratio [OR] 0.70; 95% confidence interval [CI] 0.56–0.87) and a higher odds of 3-month mortality (OR 1.49; 95% CI 1.18–1.88) after adjusting for potential confounders. In addition, achieving a BP goal of <160/90 mm Hg during the first 24 hours following MT was independently associated with a lower likelihood of 3-month mortality (OR 0.08; 95% CI 0.01–0.54; p = 0.010) in comparison to permissive hypertension.Conclusions:High maximum SBP levels following MT are independently associated with increased likelihood of 3-month mortality and functional dependence in LVO patients. Moderate BP control is also related to lower odds of 3-month mortality in comparison to permissive hypertension.
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Chappill, J., PY Ladiges, and D. Boland. "Eucalyptus Aromaphloia Pryor & Willis ̵1 a Redefinition of Geographical and Morphological Boundaries." Australian Journal of Botany 34, no. 4 (1986): 395. http://dx.doi.org/10.1071/bt9860395.
Повний текст джерелаАнотація:
Adult and seedling morphological data collected for 37 populations referred to Eucalyptus aromaphloia Pryor & Willis have been analysed using a range of multivariate classification and ordination techniques. The analysis of adult leaf, bud and fruit morphology revealed only a subtle pattern of geographical variation of limited diagnostic significance. Differentiation in terms of seedling morphology was more marked, and four groups were identified. A relatively high incidence of character segregation in progeny from individual trees was observed and.the implications of this are discussed. Two of the four groups encompass seedlings with non-glaucous, narrow juvenile leaves and round stems. The first group comprises populations from the Little Desert and the Grampian Ranges west of the Mt William Range. The juvenile leaves are linear, sessile for many nodes and often become falcate after 15-20 nodes. The second group is a single population from east of Rylstone, north-west of Sydney. The juvenile leaves are lanceolate and become petiolate but not falcate after the 15th leaf node. This population was previously referred to E. corticosa L. Johnson. The third group is similar to the type of E. aromaphloia and populations were found only in west- central Victoria, from the Mt William Range in the Grampians east to the Brisbane Range near Melbourne. Seedlings are characterised by round stems and ovate, glaucous juvenile leaves that are sessile or subsessile for many leaf nodes. Thus E. aromaphloia s. str. has a more restricted distribution than previously described. The fourth group comprises populations from eastern Victoria where the juvenile leaves are non- glaucous, broad-lanceolate, distinctly petiolate by the 11th node and the stems are often square.
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Castle, David J. "Letter from Australia: mental healthcare in Victoria." Advances in Psychiatric Treatment 17, no. 1 (January 2011): 2–4. http://dx.doi.org/10.1192/apt.bp.110.008375.
Повний текст джерелаАнотація:
SummaryMental health services in the state of Victoria, Australia, have undergone enormous change over the past 15 years, with the closure of all stand-alone psychiatric hospitals and a shift of resources and services into the community. Although successful overall, various areas cause concern, including pressure on acute beds, a paucity of alternative residential options, and suboptimal integration of government and non-government agencies concerned with the care of people with mental illnesses. Certain groups, notably those with complex symptom sets such as substance use and mental illness, intellectual disability and forensic problems, remain poorly catered for by the system. Finally, community stigma and lack of work inclusion for mentally ill individuals are ongoing challenges.
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Perinelli, Cristina, Mario Gaeta, and Pietro Armienti. "Cumulate xenoliths from Mt. Overlord, northern Victoria Land, Antarctica: A window into high pressure storage and differentiation of mantle-derived basalts." Lithos 268-271 (January 2017): 225–39. http://dx.doi.org/10.1016/j.lithos.2016.10.027.
Повний текст джерела
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Stewart, James Bruce, and Andrew T. Beckenbach. "Insect mitochondrial genomics 2: the complete mitochondrial genome sequence of a giant stonefly, Pteronarcys princeps, asymmetric directional mutation bias, and conserved plecopteran A+T-region elements." Genome 49, no. 7 (July 1, 2006): 815–24. http://dx.doi.org/10.1139/g06-037.
Повний текст джерелаАнотація:
Mitochondrial (mt) genome sequences of insects are receiving renewed attention in molecular phylogentic studies, studies of mt-genome rearrangement, and other unusual molecular phenomena, such as translational frameshifting. At present, the basal neopteran lineages are poorly represented by mt-genome sequences. Complete mt-genome sequences are available in the databases for only the Orthoptera and Blatteria; 9 orders are unrepresented. Here, we present the complete mt-genome sequence of a giant stonefly, Pteronarcys princeps (Plecoptera; Pteronarcyidae). The 16 004 bp genome is typical in its genome content, gene organisation, and nucleotide composition. The genome shows evidence of strand-specific mutational biases, correlated with the time between the initiation of leading and the initiation of lagging strand replication. Comparisons with other insects reveal that this trend is seen in other insect groups, but is not universally consistent among sampled mt-genomes. The A+T region is compared with that of 2 stoneflies in the family Peltoperlidae. Conserved stem-loop structures and sequence blocks are noted between these distantly related families.Key words: mitochondrial genomics, directional mutation pressure, A+T-rich region, Plecoptera, stonefly.
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Coleine, Claudia, Nuttapon Pombubpa, Laura Zucconi, Silvano Onofri, Benedetta Turchetti, Pietro Buzzini, Jason E. Stajich, and Laura Selbmann. "Uncovered Microbial Diversity in Antarctic Cryptoendolithic Communities Sampling Three Representative Locations of the Victoria Land." Microorganisms 8, no. 6 (June 23, 2020): 942. http://dx.doi.org/10.3390/microorganisms8060942.
Повний текст джерелаАнотація:
The endolithic niche represents an ultimate refuge to microorganisms in the Mars-like environment of the Antarctic desert. In an era of rapid global change and desertification, the interest in these border ecosystems is increasing due to speculation on how they maintain balance and functionality at the dry limits of life. To assure a reliable estimation of microbial diversity, proper sampling must be planned in order to avoid the necessity of re-sampling as reaching these remote locations is risky and requires tremendous logistical and economical efforts. In this study, we seek to determine the minimum number of samples for uncovering comprehensive bacterial and fungal diversity, comparing communities in strict vicinity to each other. We selected three different locations of the Victoria Land (Continental Antarctica) at different altitudes and showing sandstone outcrops of a diverse nature and origin—Battleship promontory (834 m above sea level (a.s.l.), Southern VL), Trio Nunatak (1,470 m a.s.l., Northern VL) and Mt New Zealand (3,100 m a.s.l., Northern VL). Overall, we found that a wider sampling would be required to capture the whole amplitude of microbial diversity, particularly in Northern VL. We concluded that the inhomogeneity of the rock matrix and the stronger environmental pressure at higher altitudes may force the communities to a higher local diversification.
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Kim, Tae Hoon, Chang Zoo Kim, Seung Uk Lee, and Sang Joon Lee. "Combined Intravitreal Bevacizumab and Laser Photocoagulation to Treat Retinal Arterial Macroaneurysms." Journal of the Korean Ophthalmological Society 62, no. 8 (August 15, 2021): 1053–60. http://dx.doi.org/10.3341/jkos.2021.62.8.1053.
Повний текст джерелаАнотація:
Purpose: To investigate the effects of intravitreal bevacizumab injection combined with laser photocoagulation in patients with retinal microaneurysms.Methods: We retrospectively reviewed the medical records of 21 eyes of 21 patients who underwent intravitreal bevacizumab injection and/or laser photocoagulation to treat retinal macroaneurysms. Eleven eyes received the combination therapy (CT) and 10 eyes monotherapy (MT) (either bevacizumab injection or laser photocoagulation). Changes in visual acuity, central macular thickness, macroaneurysm size and location, blood pressure, and the lipid level were compared between the two groups.Results: The mean patient age was 74.0 ± 10.5 years and the mean study period 7.0 ± 5.3 months. The mean macroaneurysm diameter of the CT group was 480.00 ± 292.30 μm and that of the MT group 328.75 ± 87.09 μm. The diameter was significantly larger in the CT group (p = 0.002). The initial visual acuities were 0.91 ± 0.66 and 0.88 ± 0.83 in the CT and MT groups, respectively. At the 4-month follow-up, the visual acuities were 0.33 ± 0.26 and 0.17 ± 0.29 in the CT and MT groups, respectively, and had significantly improved only in the CT group (p = 0.042). The initial central macular thicknesses were 441.82 ± 226.81 and 541.63 ± 401.97 μm in the CT and MT groups, respectively. At the 4-month follow-up, the figures were 293.60 ± 46.10 and 269.00 ± 48.34 μm in the CT and MT groups, respectively, and had significantly decreased only in the CT group (p = 0.043). Compared to the initial findings, the proportion of patients whose final visual acuities improved by more than two lines were 73% and 40%, respectively, thus significantly higher in the CT group (p < 0.001).Conclusions: Combined intravitreal bevacizumab injection and laser photocoagulation treatment of retinal macroaneurysms improve visual acuity and decrease macular thickness.
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Gallego-Sendarrubias, Gracia M., David Rodríguez-Sanz, Cesar Calvo-Lobo, and Jose Luis Martín. "Efficacy of dry needling as an adjunct to manual therapy for patients with chronic mechanical neck pain: a randomised clinical trial." Acupuncture in Medicine 38, no. 4 (March 23, 2020): 244–54. http://dx.doi.org/10.1136/acupmed-2018-011682.
Повний текст джерелаАнотація:
Objective: Chronic mechanical neck pain is associated with musculoskeletal tissue alterations. Active trigger points in the trapezius and levator scapulae muscles are common in patients with chronic mechanical neck pain. In this study, we compared the effect of dry needling (DN) combined with manual therapy (MT) to sham dry needling (SDN) combined with MT on pain, pain pressure threshold, cervical range of motion and neck disability in patients with chronic mechanical neck pain. Methods: A randomised, single-blind clinical trial was carried out involving 101 participants with chronic mechanical neck pain, divided into an intervention group (DN+MT, n=47) and a control group (SDN+MT, n=54). Participants received two treatment sessions. The intervention group received MT in conjunction with DN of the most mechano-sensitive myofascial trigger point (MTrP). The control group received MT plus SDN. Outcomes measures were: pain intensity (numeric pain rating scale, NPRS), pressure pain threshold (PPT), cervical range of motion (ROM) and neck disability (neck disability index, NDI). Results: This study found that between-group differences in pain intensity were statistically significant (P<0.01). Pain decreased after the first intervention in the DN+MT group (3.47±0.25 points on the NPRS) and even more so after the second intervention (4.76±0.24 points on the NPRS). After 4 weeks, pain intensity differed from baseline by 4.89±0.27 points on the NPRS. Statistically significant differences (P<0.001) in PPT were also found between the intervention group and the control group. After the first intervention, a significant increase in PPT within the DN+MT group (3.09±0.8 kg/cm2) was observed. Cervical ROM also showed highly statistically significant differences. After 4 weeks, a statistically significant reduction (P<0.001) in NDI was observed between the two groups. Conclusion: Our results show that DN+MT is efficacious and significantly better than SDN+MT at reducing pain intensity, PPT, neck disability and cervical ROM in patients with chronic mechanical neck pain. Level of evidence: 1b.
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PERKINS, PHILIP D. "A revision of the Australian species of the water beetle genus Hydraena Kugelann (Coleoptera: Hydraenidae)." Zootaxa 1489, no. 1 (May 31, 2007): 1–207. http://dx.doi.org/10.11646/zootaxa.1489.1.1.
Повний текст джерелаАнотація:
The Australian species of the water beetle genus Hydraena Kugelann, 1794, are revised, based on the study of 7,654 specimens. The 29 previously named species are redescribed, and 56 new species are described. The species are placed in 24 species groups. High resolution digital images of all primary types are presented (online version in color), and geographic distributions are mapped. Male genitalia, representative female terminal abdominal segments and representative spermathecae are illustrated. Australian Hydraena are typically found in sandy/gravelly stream margins, often in association with streamside litter; some species are primarily pond dwelling, a few species are humicolous, and one species may be subterranean. The areas of endemicity and species richness coincide quite closely with the Bassian, Torresian, and Timorian biogeographic subregions. Eleven species are shared between the Bassian and Torresian subregions, and twelve are shared between the Torresian and Timorian subregions. Only one species, H. impercepta Zwick, is known to be found in both Australia and Papua New Guinea. One Australian species, H. ambiflagellata, is also known from New Zealand. New species of Hydraena are: H. affirmata (Queensland, Palmerston National Park, Learmouth Creek), H. ambiosina (Queensland, 7 km NE of Tolga), H. antaria (New South Wales, Bruxner Flora Reserve), H. appetita (New South Wales, 14 km W Delagate), H. arcta (Western Australia, Synnot Creek), H. ascensa (Queensland, Rocky Creek, Kennedy Hwy.), H. athertonica (Queensland, Davies Creek), H. australula (Western Australia, Synnot Creek), H. bidefensa (New South Wales, Bruxner Flora Reserve), H. biimpressa (Queensland, 19.5 km ESE Mareeba), H. capacis (New South Wales, Unumgar State Forest, near Grevillia), H. capetribensis (Queensland, Cape Tribulation area), H. converga (Northern Territory, Roderick Creek, Gregory National Park), H. cubista (Western Australia, Mining Camp, Mitchell Plateau), H. cultrata (New South Wales, Bruxner Flora Reserve), H. cunninghamensis (Queensland, Main Range National Park, Cunningham's Gap, Gap Creek), H. darwini (Northern Territory, Darwin), H. deliquesca (Queensland, 5 km E Wallaman Falls), H. disparamera (Queensland, Cape Hillsborough), H. dorrigoensis (New South Wales, Dorrigo National Park, Rosewood Creek, upstream from Coachwood Falls), H. ferethula (Northern Territory, Cooper Creek, 19 km E by S of Mt. Borradaile), H. finniganensis (Queensland, Gap Creek, 5 km ESE Mt. Finnigan), H. forticollis (Western Australia, 4 km W of King Cascade), H. fundaequalis (Victoria, Simpson Creek, 12 km SW Orbost), H. fundata (Queensland, Hann Tableland, 13 km WNW Mareeba), H. hypipamee (Queensland, Mt. Hypipamee National Park, 14 km SW Malanda), H. inancala (Queensland, Girraween National Park, Bald Rock Creek at "Under-ground Creek"), H. innuda (Western Australia, Mitchell Plateau, 16 mi. N Amax Camp), H. intraangulata (Queensland, Leo Creek Mine, McIlwrath Range, E of Coen), H. invicta (New South Wales, Sydney), H. kakadu (Northern Territory, Kakadu National Park, Gubara), H. larsoni (Queensland, Windsor Tablelands), H. latisoror (Queensland, Lamington National Park, stream at head of Moran's Falls), H. luminicollis (Queensland, Lamington National Park, stream at head of Moran's Falls), H. metzeni (Queensland, 15 km NE Mareeba), H. millerorum (Victoria, Traralgon Creek, 0.2 km N 'Hogg Bridge', 5.0 km NNW Balook), H. miniretia (Queensland, Mt. Hypipamee National Park, 14 km SW Malanda), H. mitchellensis (Western Australia, 4 km SbyW Mining Camp, Mitchell Plateau), H. monteithi (Queensland, Thornton Peak, 11 km NE Daintree), H. parciplumea (Northern Territory, McArthur River, 80 km SW of Borroloola), H. porchi (Victoria, Kangaroo Creek on Springhill Rd., 5.8 km E Glenlyon), H. pugillista (Queensland, 7 km N Mt. Spurgeon), H. queenslandica (Queensland, Laceys Creek, 10 km SE El Arish), H. reticuloides (Queensland, 3 km ENE of Mt. Tozer), H. reticulositis (Western Australia, Mining Camp, Mitchell Plateau), H. revelovela (Northern Territory, Kakadu National Park, GungurulLookout), H. spinissima (Queensland, Main Range National Park, Cunningham's Gap, Gap Creek), H. storeyi (Queensland, Cow Bay, N of Daintree River), H. tenuisella (Queensland, 3 km W of Batavia Downs), H. tenuisoror (Australian Capital Territory, Wombat Creek, 6 km NE of Piccadilly Circus), H. textila (Queensland, Laceys Creek, 10 km SE El Arish), H. tridisca (Queensland, Mt. Hemmant), H. triloba (Queensland, Mulgrave River, Goldsborough Road Crossing), H. wattsi (Northern Territory, Holmes Jungle, 11 km NE by E of Darwin), H. weiri (Western Australia, 14 km SbyE Kalumburu Mission), H. zwicki (Queensland, Clacherty Road, via Julatten).
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Renzaho, Andre. "Re-visioning cultural competence in community health services in Victoria." Australian Health Review 32, no. 2 (2008): 223. http://dx.doi.org/10.1071/ah080223.
Повний текст джерелаАнотація:
There are few studies exploring the need to develop and manage culturally competent health services for refugees and migrants from diverse backgrounds. Using data from 50 interviews with service providers from 26 agencies, and focus group discussion with nine different ethnic groups, this paper examines how the Victorian state government funding and service agreements negatively impact on the quest to achieve cultural competence. The study found that service providers have adopted ?one approach fits all? models of service delivery. The pressure and competition for resources to address culturally and linguistically diverse communities? needs allows little opportunity for partnership and collaboration between providers, leading to insufficient sharing of information and duplication of services, poor referrals, incomplete assessment of needs, poor compliance with medical treatment, underutilisation of available services and poor continuity of care. This paper outlines a model for cultural consultation and developing needs-led rather than serviceled programs.
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Vaka, Ramana, Evangeline Deer, Mark Cunningham, Kristen M. McMaster, Kedra Wallace, Denise C. Cornelius, Lorena M. Amaral, and Babbette LaMarca. "Characterization of Mitochondrial Bioenergetics in Preeclampsia." Journal of Clinical Medicine 10, no. 21 (October 29, 2021): 5063. http://dx.doi.org/10.3390/jcm10215063.
Повний текст джерелаАнотація:
Preeclampsia (PE) is characterized by new onset hypertension during pregnancy and is associated with oxidative stress, placental ischemia, and autoantibodies to the angiotensin II type I receptor (AT1-AA). Mitochondrial (mt) dysfunction in PE and various sources of oxidative stress, such as monocytes, neutrophils, and CD4 + T cells, have been identified as important players in the pathophysiology of PE. We have established the significance of AT1-AA, TNF-α, and CD4 + T cells in causing mitochondrial (mt) dysfunction in renal and placental tissues in pregnant rats. Although the role of mt dysfunction from freshly isolated intact placental mitochondria has been compared in human PE and normally pregnant (NP) controls, variations among preterm PE or term PE have not been compared and mechanisms contributing to mt ROS during PE are unclear. Therefore, we hypothesized PE placentas would exhibit impaired placental mt function, which would be worse in preterm PE patients than in those of later gestational ages. Immediately after delivery, PE and NP patient’s placentas were collected, mt were isolated and mt respiration and ROS were measured. PE patients at either < or >34 weeks gestational age (GA) exhibited elevated blood pressure and decreased placental mt respiration rates (state 3 and maximal). Patients delivering at >34 weeks exhibited decreased Complex IV activity and expression. Placental mtROS was significantly reduced in both PE groups, compared to NP placental mitochondria. Collectively, the study demonstrates that PE mt dysfunction occurs in the placenta, with mtROS being lower than that seen in NP controls. These data indicate why antioxidants, as a potential target or new therapeutic agent, may not be ideal in treating the oxidative stress associated with PE.
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Kim, Jae-Yul. "The Specificity of Silla's Ornaments Excavated in the Tombs of Mt. Geumseong." Yeongnam Archaeological Society, no. 83 (January 30, 2019): 5–29. http://dx.doi.org/10.47417/yar.2019.83.5.
Повний текст джерелаАнотація:
The tombs of Mt. Geumseong in the Uiseong area represented an influential political entity that existed in northern Silla during the period of Three Kingdoms. Created at the feet of Mt. Geumseong, Tapri, Hakmiri, and Daeriri are collectively called the tombs of Mt. Geumseong. Interest in the ornaments found in the tombs has continued from the Goguryeo-style gilt bronze crown found in a tomb of Tapri in 1960 to the gilt bronze official hat found in a tomb of Daeriri recently. The materials of ornaments in the tombs of Mt. Geumseong are the same as those excavated in old tombs around Silla, which means that the appearance and development of Silla ornaments in the tombs of Mt. Geumseong was the result of Silla s grant of ornament system that was operated across its territory. The grant of ornament system is an archeological concept to explain the supply and demand patterns of ornaments between the central and local groups of Silla from the perspective of political dynamics. The system was based on the premise that there were the supply and demand sides or the central and local groups in Silla. It was thus predicted that the supply and demand process at the bottom of grant of ornaments was a dual structure of mutual reactions between the two groups. The investigator interpreted the characteristics of Silla s ornaments found in the tombs of Mt. Geumseong based on this. The ornament materials found in the tombs of Mt. Geumseong were categorized into the Goguryeo style, Gyeongju style, and local creations. The use of Goguryeo-style ornaments by the group of tombs of Mt. Geumseong was the result of mutual compromise between the central and local groups of Silla. The supply and demand of Goguryeo-style ornaments developed based on mutual compromise between central Silla, which was conscious of its diplomatic relations with Goguryeo, and the group of tombs of Mt. Geumseong with its geopoliticaluniqueness as a frontier. Later, the percentage of Gyeongju-style ornaments rose in the group of tombs of Mt. Geumseong. A symbolic event took place as the Goguryeo-style Woomo-shaped crown was replaced with the Gyeongju-style Suji-shaped one. It was the result of mutual reactions between the pressure from central Silla to choose Gyeongju-style ornaments according to its anti-Goguryeo policy and the emphasis on pan-Silla identity in the group of tombs of Mt. Geumseong. Ornaments made locally appeared during the period when the percentage of Gyeongju-style ornaments increased. They started with the repair of damaged ornaments and reached the level of making a complete work such as gilt bronze official hats and Isiks. They were the reproduced versions of central Silla s ornaments by the group of tombs of Mt. Geumseong, which is why their creation is not considered to represent the group s independence against pan-Silla identity. The group s reproduction of ornaments beyond the acceptance and acquisition of ornaments from the central region was the result of its active reactions to reinforce pan-Silla identity.
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Chu, Yu-Hsiu, Chih-Hsiu Cheng, Pei-Fang Tang, and Kwan-Hwa Lin. "EFFECTS OF AGE AND STEP DIRECTION ON BEHAVIORAL PERFORMANCES AND CENTER-OF-PRESSURE CHARACTERISTICS OF VOLITIONAL STEPPING IN OLDER AND YOUNG ADULTS." Biomedical Engineering: Applications, Basis and Communications 24, no. 03 (June 2012): 207–16. http://dx.doi.org/10.4015/s1016237212500032.
Повний текст джерелаАнотація:
This study investigated center-of-pressure (COP) characteristics during volitional stepping in forward, backward, and sideways directions, along with the behavioral performance measures and COP measures of volitional stepping in these directions, and the relationships between these two types of measures in healthy older and young adults. Fifteen older and 15 young adults performed rapid stepping in the three directions using each leg. Behavioral performance measures included reaction time (RT), movement time (MT), step length, and step velocity in the MT phase. COP measures included the maximum anteroposterior (COPAP) and mediolateral COP displacement (COPML) in the RT phase. Stepping in each direction demonstrated unique COP characteristics. The older adults presented slower RT, MT, step velocity, and smaller COPAP in all three stepping directions (p < 0.05), as well as smaller COPML in the sideways stepping direction (p < 0.017), compared to the young adults. Step velocity correlated with COPAP and/or COPML in all three stepping directions for both groups (r = 0.42–0.77, p < 0.05), suggesting that stepping performances during the movement execution phase correlated with COP control during the postural preparation phase. Results suggest that stepping training prescribed to older adults to improve their balance control may include multi-directional stepping.
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Chandler, Gregory T., and Michael D. Crisp. "Contributions Towards a Revision of Daviesia (Fabaceae: Mirbelieae). IV.* D. ulicifolia sens. lat." Australian Systematic Botany 10, no. 1 (1997): 31. http://dx.doi.org/10.1071/sb96013.
Повний текст джерелаАнотація:
Following a morphometric and cladistic analysis of the Daviesia ulicifolia Andrews group (Chandler and Crisp 1997), a new species, D. sejugata, is described. It occurs disjunctly in eastern Tasmania and southern Yorke Peninsula, South Australia, and is closely related to D. arthropoda F.Muell., differing in a generally more robust habit, thicker fleshy phyllodes, and larger flowers. Even with this species removed from D. ulicifolia, the latter varies considerably over a wide geographic, edaphic and altitudinal range. Daviesia ulicifolia is divided into six subspecies based on distinct phenetic and phylogenetic groups delimited in the earlier study. These are subsp. aridicola (glaucous plants in arid regions), subsp. incarnata (reddish-flowered plants in the Mt Lofty Range, South Australia), subsp. ruscifolia (plants with ovate-acuminate leaves and orange flowers in Victoria and southern New South Wales (NSW), often at high altitude), subsp. stenophylla (a narrow-leaved form in northern NSW and Queensland), subsp. pilligensis (ovate-leaved plants on sandy soil in western NSW), and subsp. ulicifolia (a paraphyletic residual from south-eastern states).
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Briones-Aranda, Alfredo, Javier Ramírez-Carballo, Bernardo Alfredo Romero Gómez, Victor Manuel Vega Villa, Manuela Castellanos Pérez, Esmeralda Garcia Parra, and Hugo Roberto Santeliz-Montero. "Influence of Bromocriptine Plus Metformin Treatment on Glycaemia and Blood Pressure in Patients with Type 2 Diabetes Mellitus." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 25, no. 1 (March 1, 2018): 59–66. http://dx.doi.org/10.2478/rjdnmd-2018-0006.
Повний текст джерелаАнотація:
Abstract Background and aims: Bromocriptine is a dopaminergic (D2) agonist that has shown hypoglycemic and normotensive activity in preclinical and clinical studies. The main objective of this study was to investigate the effect of bromocriptine plus metformin on glycaemia and blood pressure in patients with type 2 diabetes mellitus (T2DM). Material and methods: An open-label randomised controlled trial was conducted for three months. It involved two groups (n=10), each containing 2 women and 8 men with an average age of 50 years. One group was given monotherapy (MT) with metformin (850 mg every 12 h) and the other combined therapy (CT) with the same dose of metformin plus an increasing dose of bromocriptine (from 1.25 mg per day to 2.5 mg per day). The parameters monitored were glycaemia, glycated hemoglobin (HbA1c), serum creatinine, blood pressure, and the body mass index. Results: CT was able to significantly decrease the level of glycaemia, HbA1c and diastolic blood pressure, whereas MT had no effect on any of the measured variables. Conclusions: The ability of CT with bromocriptine and metformin to control glycaemia and produce a normotensive effect reaffirms its advantages for controlling T2DM. Further research is needed to improve this therapeutic strategy.
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Joseph, PhD, Leonard H., Benjamaporn Hancharoenkul, MSc, PT, Patraporn Sitilertpisan, PhD, Ubon Pirunsan, PhD, and Aatit Paungmali, PhD. "Effects of Massage as a Combination Therapy with Lumbopelvic Stability Exercises as Compared to Standard Massage Therapy in Low Back Pain: a Randomized Cross-Over Study." International Journal of Therapeutic Massage & Bodywork: Research, Education, & Practice 11, no. 4 (December 7, 2018): 16–22. http://dx.doi.org/10.3822/ijtmb.v11i4.413.
Повний текст джерелаАнотація:
Background: Little is known about the effects of providing massage as a combination therapy (CT) with lumbopelvic stability training (LPST) in management of chronic nonspecific low back pain (CLBP) among elite female weight lifters. It is unclear whether massage therapy (MT) together with LPST has any additional clinical benefits for individuals with CLBP.Purpose: The current study compares the thera-peutic effects of CT against MT as a stand-alone intervention on pain intensity (PI), pain pressure threshold (PPT), tissue blood flow (TBF), and lumbopelvic stability (LPS) among elite weight lifters with CLBP.Setting: The study was conducted at the campus for National Olympic weight lifting training camp.Participants: A total of 16 professional female elite weight lifting athletes who were training for Olympic weight lifting competition participated in the study.Research Design: A within-subject, repeated measures, crossover, single-blinded, randomized allocation study.Intervention: The athletes were randomized into three sessions of CT and MT with a time interval of 24 hrs within sessions and a wash out period of four weeks between the sessions.Main Outcome Measures: The PI, PPT, TBF, and LPS were measured before and after each session repeatedly in both groups of intervention. The changes in the PI, PPT, TBF, and LPS were analyzed using repeated measures analysis of vari-ance (ANOVA).Results: The results showed that the CT signifi-cantly demonstrated greater effects in reducing pain perception (45%–51%), improving pain pressure threshold (15% up to 25%), and increas-ing tissue blood flow (131%–152%) than MT (p < .001).Conclusion: The combination therapy of mas-sage therapy and LPST is likely to provide more clinical benefits in terms of PI, PPT, and TBF when compared to massage as a stand-alone therapy among individuals with chronic nonspecific low back pain.
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Aflitonov, M. A., S. A. Partsernyak, A. N. Mironenko, A. S. Partsernyak, and A. A. Topanova. "MELATONIN EXCHANGE AT MULTIMORBID CARDIOVASCULAR PATHOLOGYWITH ANXIETY AND DEPRESSIVE DISORDERS IN YOUNG AND MIDDLE-AGED MEN." HERALD of North-Western State Medical University named after I.I. Mechnikov 7, no. 3 (September 15, 2015): 60–65. http://dx.doi.org/10.17816/mechnikov20157360-65.
Повний текст джерелаАнотація:
Evaluate melatonin (MT) patterns excretion at multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAD), hypertension, metabolic syndrome (MS)) with non-psychot- ic mental disorders (NPMD) anxiety/ depressive type. Identify the effectiveness of visual-auditory ef- fects in the treatment of these pathologies. Design and methods: The study included 70 men (mean age 37,46±6,74) with MCVP divided into 4 groups by simple random sampling, and 20 healthy men (mean age 38,3±6,73 g). Patients in Group 1 (n = 22) received standard therapy CAD, hypertension and NPMD, in group 2 (n = 25) standard therapy CAD, hypertension, NPMD and visual-auditory correction. Patients of group 3 (n = 23) received standard therapy CAD, hypertension, NPMD, visual-auditory correction and psychotherapy. Used in the study: complex psychological test methods and laboratory-instrumental evaluation of the cardiovascular system. Definition of 6-sulfatoxymelatonin (6-SMT) performed by ELI- SA using kits BÜHLMANNEK-M6S. Results: Identified change normal «dipper» pattern to «non- dip- per» and «night-peaker» (daily index blood pressure and 0-10% <0% (p <0,001) in all treatment groups. Patients 3 group observed achievement reference values of the night excretion after treatment 458±64-» 798±32 (before and after treatment, respectively) (p <0,001). In all groups after treatment was observed significantly change the type of NDP «severe depression», «clinical anxiety» to «mild depression»; «sub- clinical anxiety» (p <0,001). Conclusions: Patients with MCVP have abnormalities of MT content char- acterized by a decrease in nocturnal excretion of 6-SMT. Night pattern of 6-SMT excretion significantly correlated with severity of anxiety/ depression before and after treatment. Results of patients treated with visual auditory correction significantly better than patients of other groups (obtained reference intervals MT excretion, biochemical indices and normalization of psychological tests).
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S., Martín Pérez, Montaño Ocaña J., Barragán Carballar C., and Arribas Pérez H. "Effectiveness of joint mobilization and dry needling in myofascial pain syndrome with neck pain." Revista Fisioterapia Invasiva / Journal of Invasive Techniques in Physical Therapy 02, no. 02 (December 2019): 096–97. http://dx.doi.org/10.1055/s-0039-3401874.
Повний текст джерелаАнотація:
Abstract Background and Aim Almost 70% of the population has suffered from cervical pain of a mechanical origin (CPM) at some point in their life. In myofascial pain syndrome (MPS), besides the zygapophyseal joint, the myofascial trigger point (MTrP) is involved as the main source of CPM. Manual therapy (MT) based on joint mobilization (JM) in combination with dry needling (DN), are the most used treatments in these patients. Aims 1) To compare the pain and range of motion (ROM) between the MT interventions using JM and deep DN and MT using JM and sham DN in patients with CPM and activation of MTrP 2 of the upper trapezius (UT). 2) To assess the changes in the active cervical ROM, pain pressure threshold (PPT), intensity of pain at rest and with movement (measured using the Visual Analog Scale) and post-needling soreness in these patients. Material and Methods An experimental, double blind randomized pilot study in which the effects produced by the interventions were compared among two groups: a first group (n = 5) received a treatment based on sham DN of the UT and MT using JM of C2 and a second group (n = 6) who received deep DN of the MTrP 2 of the UT and the same mobilization technique. Three prospective measurements were performed: pre-intervention, post-intervention and follow-up (1 month after the post-intervention measurement). Results 11 subjects participated in this study (7 women and 4 men; mean age: 49.9 ± 10.8 years) who completed both the four interventions (1 session/week) as well as the follow-up. According to the PPT, measured on the MTrP 2 of the UT, none of the two groups presented clinically significant changes, and only 3 patients presented increases beyond the MDC (MDC) in the follow-up measurement (1.11 kg/cm2). Regarding the VAS measured at rest, only the first group (sham DN) obtained a clinically significant post intervention improvement (56%) and at follow-up (150%). The VAS in response to movement decreased significantly with treatment in both groups for all movement planes and axes; however, the active cervical ROM did not display significant changes in any of the two groups; lastly, the mean, maximum and minimum values of post-needling soreness in the group with placebo DN were lesser to those of the group who received the real deep DN technique, for the entire treatment. Conclusion Deep DN combined with MT improved the intensity of pain in response to cervical movement, whereas sham dry needling combined with MT caused a greater decrease of intensity at rest. Although both techniques are similar for improving active cervical ROM, sham DN combined with MT increased post-needling soreness both during treatment as well as at follow-up. Further research is necessary to deepen our information of the effects of the combination of these two techniques in the treatment of MPS.
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Srivastava, Kamna, Sudhir Chandra, Jagriti Bhatia, Rajiv Narang, and Daman Saluja. "Association of Angiotensinogen (M235T) Gene Polymorphism with Blood Pressure Lowering Response to Angiotensin Converting Enzyme Inhibitor (Enalapril)." Journal of Pharmacy & Pharmaceutical Sciences 15, no. 3 (July 16, 2012): 399. http://dx.doi.org/10.18433/j3kw3b.
Повний текст джерелаАнотація:
Purpose: It has been suggested that genetic backgrounds, which have an association with essential hypertension, may also determine the responsiveness to ACE inhibitor. We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects. Methods: 250 patients with essential hypertension and 250 normal healthy controls from Delhi and surrounding areas were recruited for the investigation. Blood pressure was recorded before and after 6 weeks of treatment with ACE inhibitors, Enalapril. Genotyping were carried out by polymerase chain reaction and Restriction fragment length polymorphism technique. Results: Statistically significant association of T allele was observed with essential hypertension [x2 = 14.67, p = 0.00013, Odds ratio = 1.76 (1.3-2.32) at 95% CI], the relative risk at 95% CI being 1.28 (1.2-1.54). The decrease in systolic blood pressure and diastolic blood pressure after six weeks of treatment of the patients carrying TT genotype (SBP = 26±17.4 mmHg, DBP = 14.83±7.6mmHg) were greater than the groups carrying MT (SBP = 3.0±7.8 mmHg, DBP =6.2±3.0 mmHg) and MM genotypes (SBP = 1.2±0.8 mmHg, DBP = 0.10±12.1 mm Hg. Conclusions: The angiotensinogen (M235T) gene polymorphism is significantly associated with essential hypertension. Patients carrying TT genotype had higher blood pressure lowering response when treated with ACE inhibitor, Enalapril than those carrying MM and MT genotypes suggesting that the T allele may be a possible genetic marker for essential hypertension.
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Doulamis, Ilias P., Alvise Guariento, Thomas Duignan, Arzoo Orfany, Takashi Kido, David Zurakowski, Pedro J. del Nido, and James D. McCully. "Mitochondrial transplantation for myocardial protection in diabetic hearts." European Journal of Cardio-Thoracic Surgery 57, no. 5 (November 28, 2019): 836–45. http://dx.doi.org/10.1093/ejcts/ezz326.
Повний текст джерелаАнотація:
Abstract OBJECTIVES Type 2 diabetes causes mitochondrial dysfunction, which increases myocardial susceptibility to ischaemia–reperfusion injury. We investigated the efficacy of transplantation of mitochondria isolated from diabetic or non-diabetic donors in providing cardioprotection from warm global ischaemia and reperfusion in the diabetic rat heart. METHODS Ex vivo perfused hearts from Zucker diabetic fatty (ZDF fa/fa) rats (n = 6 per group) were subjected to 30 min of warm global ischaemia and 120 min reperfusion. Immediately prior to reperfusion, vehicle alone (VEH) or vehicle containing mitochondria isolated from either ZDF (MTZDF) or non-diabetic Zucker lean (ZL +/?) (MTZL) skeletal muscle were delivered to the coronary arteries via the aortic cannula. RESULTS Following 30-min global ischaemia and 120-min reperfusion, left ventricular developed pressure was significantly increased in MTZDF and MTZL groups compared to VEH group (MTZDF: 92.8 ± 5.2 mmHg vs MTZL: 110.7 ± 2.4 mmHg vs VEH: 44.3 ± 5.9 mmHg; P < 0.01 each); and left ventricular end-diastolic pressure was significantly decreased (MTZDF 12.1 ± 1.3 mmHg vs MTZL 8.6 ± 0.8 mmHg vs VEH: 18.6 ± 1.5 mmHg; P = 0.016 for MTZDF vs VEH and P < 0.01 for MTZL vs VEH). Total tissue ATP content was significantly increased in both MT groups compared to VEH group (MTZDF: 18.9 ± 1.5 mmol/mg protein/mg tissue vs MTZL: 28.1 ± 2.3 mmol/mg protein/mg tissue vs VEH: 13.1 ± 0.5 mmol/mg protein/mg tissue; P = 0.018 for MTZDF vs VEH and P < 0.01 for MTZL vs VEH). Infarct size was significantly decreased in the MT groups (MTZDF: 11.8 ± 0.7% vs MTZL: 9.9 ± 0.5% vs VEH: 52.0 ± 1.4%; P < 0.01 each). CONCLUSIONS Mitochondrial transplantation significantly enhances post-ischaemic myocardial functional recovery and significantly decreases myocellular injury in the diabetic heart.
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Vucicevic, Vera, Branko Milakovic, Milorad Tesic, Jelena Djordjevic, and Srdjan Djuranovic. "Manual versus target-controlled infusion of balanced propofol during diagnostic colonoscopy: A prospective randomized controlled trial." Srpski arhiv za celokupno lekarstvo 144, no. 9-10 (2016): 514–20. http://dx.doi.org/10.2298/sarh1610514v.
Повний текст джерелаАнотація:
Introduction. There is an increasing interest in balanced propofol sedation (BPS) for colonoscopy in outpatient settings. Propofol is a potent anesthetic agent for this purpose and has a narrow therapeutic range, which increases a risk of cardiovascular and respiratory complications in case of improper administration. Objective. The aim of this study was to compare patients? safety and comfort of endoscopists in two methods of BPS targeting deep sedation - propofol target-controlled infusion (TCI) and manual intravenous titration technique (MT) - during colonoscopy. Methods. This prospective randomized controlled trial included 90 patients (class I or II of the American Society of Anesthesiologists) deeply sedated with propofol, coadministered with small doses of midazolam and fentanyl. Propofol was given by MT technique (45 patients) or by TCI (45 patients). The following adverse effects were recorded: hypotension, hypertension, bradycardia, tachycardia, hypoxemia, bradypnea, apnea, hiccupping, and coughing, as well as endoscopist?s comfort during colonoscopy by means of a questionnaire. Results. The MT group compared to the TCI group had a lower mean arterial pressure in the 10th minute after the beginning (p = 0.017), and at the end of colonoscopy (p = 0.006), higher oxygen saturation in the fifth minute (p = 0.033), and in the 15th minute (p = 0.008) after the beginning of colonoscopy, and lower heart rate at the beginning of the procedure (p = 0.001). There were no statistically significant differences in adverse events. Endoscopist?s comfort during colonoscopy was high 95.6% in the TCI group vs. 88.9% in the MT group (p = 0.069). Conclusion. MT is clinically as stable as TCI of propofol for deep sedation during colonoscopy, and endoscopists experienced the same comfort during colonoscopy in both groups. Thus, both combinations are suitable for deep sedation during diagnostic colonoscopy.
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Ciążyńska, Julia, and Janusz Maciaszek. "Effects of Low-Immersive vs. High-Immersive Exercise Environment on Postural Stability and Reaction and Motor Time of Healthy Young Adults." Journal of Clinical Medicine 12, no. 1 (January 3, 2023): 389. http://dx.doi.org/10.3390/jcm12010389.
Повний текст джерелаАнотація:
(1) Background: Many young adults spend their time playing games and watching television. This type of spending time should be used effectively, so it’s worth adding exercise and immersion to them. Bearing in mind that the video games and physical exercise also improve postural stability, motor time (MT) and reaction time (RT), it is worth reaching for new technologies with immersion that are widely available and can be used, for example, as a remote intervention. This study aimed to compare the effects of a low vs. high-immersive exercise environment on postural stability, RT and MT in young adults. (2) Methods: Ninety-three participants were randomly divided into a control group (CG; n = 48) and experimental group (EG; n = 45). The CG exercised according to the Tabata self-made video display on a television set, and the EG exercised according to the Audio Trip exergame. In addition to the postural stability, RT and MT, we monitored the heart rate, breath rate and energy expenditure for safety reasons and to note any differences. (3) Results: Significant differences were observed for both groups in RT (F(2.182) = 3.14, p = 0.046, η2 = 0.03) and MT (F(2.182) = 3.07, p = 0.049, η2 = 0.03) and in postural stability in eyes closed (EC): F(2.182) = 3.66, p = 0.028, η2 = 0.04 and eyes open in one leg (EO-OL): F(2.182) = 5.814, p = 0.04, η2 = 0.07. (4) Conclusions: The inclusion of a higher immersion produces greater improvements in RT, MT. Additionally, after a low-immersive exercise environment, participants have higher center of pressure (COP) path length values with EC and EO-OL tests, which testifies to less postural stability. Regarding COP trajectory, a smaller area surface means better performance for high-immersive participants after 30 min of exercise.
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Huang, Ya-li, Yu-qing Lei, Jian-feng Liu, Hua Cao, Xian-rong Yu, and Qiang Chen. "Comparison of the Effectiveness of Music Video Therapy and Music Therapy on Pain after Cardiothoracic Surgery in Preschool Children." Heart Surgery Forum 24, no. 2 (March 26, 2021): E299—E304. http://dx.doi.org/10.1532/hsf.3509.
Повний текст джерелаАнотація:
Objective: To explore the effects of music video therapy on pain among preschool children after cardiothoracic surgery. Methods: Patients in the music video therapy (MVT) group received a 30-min music video intervention, while patients in the music therapy (MT) group received a 30-min musical intervention. Both groups were given their respective therapy three times a day for three days. Patients in the control group did not receive MVT or MV. Measures, including pain scores, vital signs (heart rate, mean arterial pressure, respiratory rate, and oxygen saturation), and other postoperative indicators were recorded and analyzed. Results: The MVT group showed a statistically significant decrease in heart rate, mean arterial pressure, and respiratory rate at the first day after surgery and pain scores at the first and second day after surgery compared to the MT group, but no significant difference was identified in oxygen saturation. The postoperative indicators including cumulative capacity of sufentanil use, the length of intensive care unit (ICU) stay, and the length of hospital stay in the MVT group were significantly lower than those in the control group. Conclusion: The findings provide further evidence to support the practice of music video therapy as a non-pharmaceutical intervention to reduce postoperative pain, reduce the dosage of analgesics, shorten the length of ICU and hospital stay in preschool children after the cardiothoracic surgery.
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Kwena, Zachary, Raphael Ondondo, Catherine Makokha, and Elizabeth Bukusi. "PO 8550 NATURE AND PREVALENCE OF MULTI-MORBIDITY IN FISHING COMMUNITIES ON LAKE VICTORIA, KENYA." BMJ Global Health 4, Suppl 3 (April 2019): A52.2—A52. http://dx.doi.org/10.1136/bmjgh-2019-edc.137.
Повний текст джерелаАнотація:
IntroductionMultimorbidity, coexistence of two or more chronic conditions, is becoming more common across different demographic groups in sub-Saharan Africa. We investigate the nature and prevalence of multimorbidity in fishing communities on Lake Victoria in Kenya.MethodsWe conducted a cross-sectional survey enrolling 679participants in the fishing communities to establish theprevalence of HIV and non-communicable diseases (NCDs)and associated risk factors. The NCDs targeted included diabetes mellitus detected by random blood glucose (RBG) and kidney dysfuction detected by serum creatinine level and proteniuria. Hypertension was defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg. Diabetes mellitus was defined as RBG >7.8 mmol/L and renal dysfunction was defined as estimated glomerular filtration rate (eGFR) <60 mL/min or proteinuria. HIV was tested using rapid Determine assays and reactive results confirmed with UniGold assays. Additionally, participants were determined as having the condition if they reported being on medication for the condition. We analysed the results using descriptive statistics and used Chi-square test to discern if there were statistically significant differences by gender.ResultsOverall, HIV prevalence was 36% while 15%, 12% and 8% of the participants were suspected to have kidney dysfuction, hypertension and diabetes mellitus, respectively. Overall, 12% of the participants had multimorbidity. The most common multimorbidity among those with any of the four chronic conditions was HIV and kidney dysfunction (29%), followed by hypertension and kidney dysfuction (22%), HIV and hypertension (20%), HIV and diabetes (18%), diabetes and kidney disease (6%) and, lastly, diabetes and hypertension (5%). Apart from HIV, we observed no statistically significant gender differences for any of the NCDs or various multimorbidity conditions.ConclusionThese fishing communities have a high burden of both HIV and NCDs resulting in high prevalence of different multimorbidities.
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Rivoire, Henri Chaplin, Djalma José Fagundes, Sergio Bigolin, and Anna Tereza Negrini Fagundes. "Hysteroscopy and the butyl-cyanoacrylate on experimental sterilization of rabbit uterine tubes." Acta Cirurgica Brasileira 22, no. 5 (October 2007): 396–400. http://dx.doi.org/10.1590/s0102-86502007000500012.
Повний текст джерелаАнотація:
PURPOSE: To assess the sterilization effectiveness on uterine tube of rabbit by the cyanoacrylate adhesive. METHODS: Hysteroscopy tubal catheterization was performed randomly in 12 animals (24 uterine tubes) assigned to the sham group (GS) and 15 animals (30 uterine tubes) to the n-butyl-cyanoacrylate (GB). The female rabbits were observed during 30, 90 and 180 days and mated to fertile males. The no pregnant rabbits were submitted to in vitro burst pressure test for patency by air insufflation (40 mmHg). The microscopic assessment was performed to parameters of damages in epithelium caused by the adhesive, the degree of inflammatory process, morphometry data values of tube diameter (UT) (cm), mucosa thickness (MT) and the myosalpinx thickness (MyT) (mm). The mucosa cells densitometry (total optical density) was expressed by the amount of DNA. The significance of the differences in histological scores and in thickness measurements were made by ANOVA test (P value < 0.05). RESULTS: In all animals of GB: the adhesive was attached to the mucosa; there was no pregnancy; no records of significant degree on inflammatory process; the patency test was negative and densitometry of DNA showed similar values to the both groups independently of observation periods. The layers thickness of GB-UT(1.118±0.117), GB-MT(0.447±0.247) and GB-MyT(0.853±0.097) were larger than the GS-UT(0.666±0.409), GS-MT(0.211±0.070) and GS-MyT(0.442±0.143). CONCLUSION: This approach offers a safe and feasible method of uterine tube obstruction.
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Gapon, L. I., E. V. Mikova, N. Yu Savelyeva, A. Yu Zherzhova, and T. M. Ripp. "Differences in the effectiveness of sympathetic radiofrequency denervation of the renal arteries in patients with resistant arterial hypertension and hyperuricemia." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 28, no. 4 (June 24, 2022): 428–43. http://dx.doi.org/10.18705/1607-419x-2022-28-4-428-443.
Повний текст джерелаАнотація:
Objective. To evaluate of differences in the effectiveness of sympathetic radiofrequency denervation (RDN) of renal arteries (RA) in patients with resistant arterial hypertension (RAH) with hyperuricemia (HUA) during 3 years of follow-up. Design and methods. The study included 80 patients with RAH, who were randomized to RDN RA group with medication therapy (MT) and MT group. Groups were comparable in age, gender, duration of hypertension and the number of antihypertensive medications. In 12 months, comparative study was completed, and RDN RA group of patients was examined in 24 and 36 months, results were analyzed depending on the initial level of uric acid (UA). Results. In RDN RA group, compared with MT group, beneficial antihypertensive effect was found both in terms of office blood pressure (BP) and ambulatory BP monitoring (ABPM). After RDN RA, significant decrease in BP persisted for 3 years. Analysis of antihypertensive effect of interventional treatment depending on UA level showed significant decrease in office BP and all indicators of ABPM in patients with normal levels of UA. In HUA patients, only decrease in office BP and mean daily systolic BP was revealed. The majority of patients with favorable response to RDN (“responders” group) showed normal UA (75 % vs. 83,3 %, respectively, at 24, 36 months of follow-up). The creatinine and cystatin C levels in dynamics were slightly increased, but within reference ranges. Conclusions. Obtained data indicated more pronounced clinical efficacy of RDN RA in patients without HUA.
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Kaasalainen, Ulla, Veera Tuovinen, Paul M. Kirika, Neduvoto P. Mollel, Andreas Hemp, and Jouko Rikkinen. "Diversity of Leptogium (Collemataceae, Ascomycota) in East African Montane Ecosystems." Microorganisms 9, no. 2 (February 3, 2021): 314. http://dx.doi.org/10.3390/microorganisms9020314.
Повний текст джерелаАнотація:
Tropical mountains and especially their forests are hot spots of biodiversity threatened by human population pressure and climate change. The diversity of lichens in tropical Africa is especially poorly known. Here we use the mtSSU and nuITS molecular markers together with morphology and ecology to assess Leptogium (Peltigerales, Ascomycota) diversity in the tropical mountains of Taita Hills and Mt. Kasigau in Kenya and Mt. Kilimanjaro in Tanzania. The sampled habitats cover a wide range of ecosystems from savanna to alpine heath vegetation and from relatively natural forests to agricultural environments and plantation forests. We demonstrate that Leptogium diversity in Africa is much higher than previously known and provide preliminary data on over 70 putative species, including nine established species previously known from the area and over 60 phylogenetically, morphologically, and/or ecologically defined Operational Taxonomic Units (OTUs). Many traditional species concepts are shown to represent morphotypes comprised of several taxa. Many of the species were only found from specific ecosystems and/or restricted habitats and are thus threatened by ongoing habitat fragmentation and degradation of the natural environment. Our results emphasize the importance of molecular markers in species inventories of highly diverse organism groups and geographical areas.
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Moschos, Marilita M., Eirini Nitoda, Konstantinos Laios, Dimitrios S. Ladas, and Irini P. Chatziralli. "The Impact of Chronic Tobacco Smoking on Retinal and Choroidal Thickness in Greek Population." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/2905789.
Повний текст джерелаАнотація:
Aim. To investigate the effect of more than 25-year cigarette smoking on choroidal and retinal thickness, using spectral domain optical coherence tomography (SD-OCT).Methods. Thirty-one smokers and 25 age- and sex-matched nonsmokers, serving as control group, were submitted to slit-lamp biomicroscopy and dilated fundoscopy, SD-OCT, measurements of intraocular pressure (IOP), central corneal thickness (CCT), and axial length (AL). Heidelberg Spectralis was used to calculate choroidal thickness (CT), ganglion cell complex (GCC), outer retina layers (ORL), and macular thicknesses (MT).Results. The smokers’ group consisted of 17 males and 14 females with mean age of 57.8 ± 4.5 years, while the controls’ group consisted of 14 males and 11 females with mean age of 68.0 ± 4.1 years. CT and GCC thicknesses were significantly reduced in smokers compared to control group. The differences in thicknesses of ORL were marginally significant between two groups. The measurements of MT, IOP, CCT, and AL had the same distributions between smokers and nonsmokers.Conclusions. Tobacco smoking seems to result in thinner choroid and retina compared to nonsmokers. This is the first study in literature that investigates the anatomical effect of smoking for more than 25 years on the choroid and retina.
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Hotfiel, Thilo, Tobias Golditz, Jessy Wegner, Johannes Pauser, Matthias Brem, Bernd Swoboda, and Hans-Dieter Carl. "A cross-sectional study on foot loading patterns in elite soccer players of different ages." Journal of Back and Musculoskeletal Rehabilitation 33, no. 6 (November 11, 2020): 939–46. http://dx.doi.org/10.3233/bmr-181436.
Повний текст джерелаАнотація:
BACKGROUND: Alterations in plantar loading patterns are risk factors for stress injuries of the lower limb, particularly of the foot and ankle. Epidemiological studies have revealed a higher incidence of soccer-related stress fractures of the fifth metatarsal (MT V) in younger athletes than in their adult counterparts. OBJECTIVE: The aim of the present study was to assess the plantar pressure distributions of members of four high-level soccer teams of different age groups to identify age-related differences in loading patterns. METHODS: A total of 65 elite soccer players were included in the study. Data were computed with sensor-loaded insoles (pedar® X system, novel Inc., Munich, Germany) while the players ran in soccer shoes. Plantar pressures for nine defined regions on the preferred and nonpreferred foot were analyzed. RESULTS: The participants consisted of 17 elite male soccer professionals from the first national league (mean 23 years, height 184 cm, weight 81 kg), 14 players from the under-21 squad (U21, 20 years, 180 cm, 75 kg), 15 players from the U17 squad (16 years, 176 cm, 69 kg) and 19 players from the U16 squad (15 years, 179 cm, 70 kg). We detected statistically significantly elevated peak pressures on the lateral aspects of the nonpreferred foot compared with the preferred foot in the U16 and U17 players, corresponding to a relative increase by 29% (p= 0.044) in the lateral midfoot, a relative increase by 24% (p= 0.031) in MT heads 4–5 in the U16 players and a difference of 18% (p= 0.049) in the lateral midfoot in the U17 players. In contrast, the U21 and adult professional players displayed symmetric plantar pressure distributions in all foot regions. CONCLUSIONS: In contrast to adult elite soccer players, adolescents demonstrate asymmetric foot loading patterns with increased peak loads in the lateral aspects of the nonpreferred foot. Our results may provide some explanation for MT V stress fractures that occur in elite adolescents.
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Ayvaz, Mehmet, and Hakan Cetinel. "Mechanical properties of Al-Cu/B4C and Al-Mg/B4C metal matrix composites." Materials Testing 63, no. 4 (April 1, 2021): 350–55. http://dx.doi.org/10.1515/mt-2020-0052.
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Abstract To be able to successfully produce ceramic-reinforced aluminum matrix composites by using the powder metallurgy method, the wetting of ceramic reinforcements should be increased. In addition, the negative effects of the oxide layer of the aluminum matrix on sinterability should be minimized. In order to break the oxide layer, the deoxidation property of Mg can be used. Furthermore, by creating a liquid phase, both wettability and sinterability can be improved. In this study, the effects of Mg and Cu alloy elements and sintering phase on the wettability, sinterability, and mechanical properties of Al/B4C composites were investigated. For this purpose, various amounts (5, 10, 20, and 30 wt.-%) of B4C reinforced Al5Cu and Al5Mg matrix composites were produced by the powder metallurgy method. After pressing under 400 MPa pressure, composite samples were sintered for 4 hours. The sintering was carried out in two different groups as solid phase sintering at 560 °C and liquid phase sintering at 610 °C. Despite the deoxidation effect of Mg in Al5Mg matrix composites, higher mechanical properties were determined in Al5Cu composites which were sintered in liquid phase because wettability increased. The highest mechanical properties were obtained in the 20 wt.-% B4C reinforced Al5Cu sample sintered in liquid phase.
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Kwak, Myounghai, Jeong-Ki Hong, Eun Sil Lee, Byoung Yoon Lee, Min Hwan Suh, and Bert Cregg. "Evaluation of Genetic Diversity in Korean Fir Cultivars Based on Microsatellite and Cytoplasmic Markers." Journal of the American Society for Horticultural Science 145, no. 1 (January 2020): 45–52. http://dx.doi.org/10.21273/jashs04781-19.
Повний текст джерелаАнотація:
Korean fir (Abies koreana) has been cultivated for less than 100 years, mainly in the United States and Europe. Using nuclear microsatellite, mitochondrial, and chloroplast markers, we investigated the origin of cultivated korean fir from South Korea (KC group) as well as the United States and United Kingdom (EU group), and compared these samples to published data from wild populations. All genotypes in the EU and KC groups were most closely related to the wild individuals from Mt. Hallasan, the southernmost A. koreana population on Jejudo Island (South Korea). However, the presence of the chloroplast haplotypes clustered with Abies balsamea in two EU cultivars and the higher diversity values of the EU group compared with the wild individuals from Mt. Hallasan infer a certain level of introgression from different species during cultivation. The EU group had a higher inbreeding coefficient and linkage disequilibrium, and a smaller proportion of rare alleles, than the wild populations. This suggests that the genetic characteristics of korean fir cultivars reflect strong artificial selection pressure for desirable horticultural traits and asexual reproduction. Last, this genetic background study suggests that the other wild populations in the Korean peninsula can serve as valuable genetic resources for future breeding.
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Balbueno, Melina Castilho de Souza, Kleber da Cunha Peixoto, and Cidéli de Paula Coelho. "Evaluation of the Efficacy of Crataegus oxyacantha in Dogs with Early-Stage Heart Failure." Homeopathy 109, no. 04 (July 17, 2020): 224–29. http://dx.doi.org/10.1055/s-0040-1710021.
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Abstract Background Myxomatous mitral valve disease (MMVD) is the most common cardiopathy in middle-aged dogs. When the dog is asymptomatic and has an enlarged left atrium, treatment is beneficial; however, some allopathic drugs are very costly and may produce side effects. To extend the duration of this asymptomatic phase, complementary therapies such as herbal medicine and homeopathy are available. Although herbal therapy with extract of Crataegus oxyacantha is beneficial, there is a risk of adverse reactions—unlike with homeopathy, where the risk is minimized with the administration of ultra-diluted doses. Objective This study evaluated the efficacy of Crataegus oxyacantha, as mother tincture (MT) and in 6 cH homeopathic formulation, in treating the initial phase of heart failure due to MMVD in a veterinary clinic setting. Methods A total of 30 dogs with MMVD, 7 years or older and weighing up to 10 kg, were randomized into three groups as follows: Crataegus 6 cH, Crataegus MT, and hydroalcoholic solution (placebo). Animals were evaluated through echocardiography parameters, laboratory blood tests, and systolic blood pressure (SBP) measurements at 30, 60, 90, and 120 days after initiation of therapy, for statistical analysis and monitoring of the blinded study. Results Patients who received Crataegus 6 cH showed a reduction in SBP 60 days after treatment, while those receiving Crataegus MT exhibited a reduction 90 days after the therapy was initiated. There was a significant linear regression when evaluating the effect of treatment with Crataegus 6 cH on SBP measurements over the evaluation intervals (linear equation: SBP = 176.57 mm Hg – 0.21x, where x represents days of treatment). There was an increase in both fractional shortening and isovolumetric relaxation time for those patients receiving the homeopathic formulation. Conclusions Therapy with Crataegus was beneficial for hypertensive and cardiopathic dogs with MMVD, extending the duration of the asymptomatic phase. The reduction in SBP occurred more swiftly in the 6 cH group than in the MT-treated dogs.
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Wang, Jennifer, Zyg Chapman, Emma Cole, Satomi Koide, Eldon Mah, Simon Overstall, and Dean Trotter. "Use of Closed Incision Negative Pressure Therapy (ciNPT) in Breast Reconstruction Abdominal Free Flap Donor Sites." Journal of Clinical Medicine 10, no. 21 (November 5, 2021): 5176. http://dx.doi.org/10.3390/jcm10215176.
Повний текст джерелаАнотація:
Background: Closed incision negative pressure therapy (ciNPT) may reduce the rate of wound complications and promote healing of the incisional site. We report our experience with this dressing in breast reconstruction patients with abdominal free flap donor sites. Methods: A retrospective cohort study was conducted of all patients who underwent breast reconstruction using abdominal free flaps (DIEP, MS-TRAM) at a single institution (Royal Melbourne Hospital, Victoria) between 2016 and 2021. Results: 126 female patients (mean age: 50 ± 10 years) were analysed, with 41 and 85 patients in the ciNPT (Prevena) and non-ciNPT (Comfeel) groups, respectively. There were reduced wound complications in almost all outcomes measured in the ciNPT group compared with the non-ciNPT group; however, none reached statistical significance. The ciNPT group demonstrated a lower prevalence of surgical site infections (9.8% vs. 11.8%), wound dehiscence (4.9% vs. 12.9%), wound necrosis (0% vs. 2.4%), and major complication requiring readmission (2.4% vs. 7.1%). Conclusion: The use of ciNPT for abdominal donor sites in breast reconstruction patients with risk factors for poor wound healing may reduce wound complications compared with standard adhesive dressings; however, large scale, randomised controlled trials are needed to confirm these observations. Investigation of the impact of ciNPT patients in comparison with conventional dressings, in cohorts with equivocal risk profiles, remains a focus for future research.
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Vasovic, Olga, Danijela Trifunovic, Nebojsa Despotovic, and Dragoslav Milosevic. "Chronic low-grade inflammation, lipid risk factors and mortality in functionally dependent elderly." Vojnosanitetski pregled 67, no. 7 (2010): 562–68. http://dx.doi.org/10.2298/vsp1007562v.
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Background/Aim. It has been proved that a highly sensitive C-reactive protein (hsCRP) can be used as an established marker of chronic inflammation for cardiovascular risk assessment. Since mean values of both low-density cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) decrease during aging, the knowledge that increased hsCRP concentration predicts mortality (Mt) would influence therapy and treatment outcome. The aim of this study was to examine importance of chronic low grade inflammation and its association with lipid risk factors for all-cause Mt in functionally dependent elderly. Methods. The participants of this longitudinal prospective study were 257 functionally dependent elderly aged 65-99 years. Baseline measurements: anthropometric measurements, blood pressure, fasting plasma total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, non- HDL-C, hemoglobin A1c (HbA1c) were recorded and different lipid ratios were calculated. Inflammation was assessed by the levels of white blood cells, fibrinogen and hsCRP. The participants with hsCRP grater than 10 mg/L were excluded from the study. The residual participants (77.4% women) were divided into three groups according to their hsCRP levels: a low (< 1 mg/L, n = 70), average (1 to 3 mg/L, n = 69), and high (3-10 mg/L, n = 69) hsCRP group. Associations of all-cause Mt with different risk factors were examined using logistic regression analysis. Results. The hsCRP level showed a significant positive correlation with waist (r = 0.199, p = 0.004) and hip (r = 0.187, p = 0.007) circumferences, body mass index (r = 0.143, p = 0.040) and serum triglyceride level (r = 0.139, p = 0.045) and significant negative correlation with HDL-C (r = -0.164, p = 0.018). Ratios TC/HDL-C and TG/HDL-C were significantly smaller in the low hsCRP group compared to the average hsCRP group (p = 0.019, p = 0.045, respectively) and without significant differences compared with the high hsCRP group. Two years after the baseline examination 22.1% participants died from all-cause Mt. After adjustment for other risk factors, a TC was significantly associated with all-cause Mt only in high hsCRP group: Odds ratio (OR) = 3.71 (95% confidence interval-CI : 1.09-12.63). Conclusions. In this study a high hsCRP was an important factor to identify functionally dependent elderly at high risk who may have more benefit from agressive lipid lowering treatment.
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Clay, Fiona J., and Joan Ozanne-Smith. "Private hospital insurance status among a state-wide injured population." Australian Health Review 30, no. 2 (2006): 252. http://dx.doi.org/10.1071/ah060252.
Повний текст джерелаАнотація:
Injury is a leading cause of inpatient hospital episodes. Over a 4-year period (1997?2000) the Australian Government introduced measures to support the private health insurance industry by providing incentives for people to take up private health insurance (PHI) in order to take the pressure off public hospitals. This study examined the levels of PHI for moderately and severely injured people in Victoria as a way of determining the effectiveness of government incentives. The method involved an analysis of all Victorian public and private hospital injury admissions between July 2000 and June 2003. We found that people with injuries, either unintentional or intentional, had lower levels of PHI than state norms. While numbers of injured patients occupying private hospital beds initially increased, levels then dropped below the levels before the introduction of the incentives. The burden of injury is substantial and suggests that incentives need to be targeted towards at-risk groups.
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Yu, Huixian, Sihao Liu, Pei Dai, Zhaoxia Wang, Changbin Liu, and Hao Zhang. "Effects of Repetitive Transcranial Magnetic Stimulation on Gait and Postural Control Ability of Patients with Executive Dysfunction after Stroke." Brain Sciences 12, no. 9 (September 2, 2022): 1185. http://dx.doi.org/10.3390/brainsci12091185.
Повний текст джерелаАнотація:
Objective: To assess the effects of repetitive transcranial magnetic stimulation (rTMS) on the gait and postural control ability of patients with executive dysfunction (ED) after stroke. Methods: A total of 18 patients with ED after stroke were randomly assigned into two groups, including an experimental group and a sham group. Patients in both groups received routine rehabilitation therapy, and patients in the experimental group underwent rTMS on the left dorsolateral prefrontal cortex (DLPFC) for 2 weeks (5 HZ, 80%MT, 1200 pulses). In the sham group, patients experienced sham stimulation treatment, in which the coil was placed vertically with the head. Before and after treatment, patients in both groups were subjected to Montreal cognitive assessment (MoCA) scoring, Fugl–Meyer assessment of lower extremity (L-FMA), Stroop color-word test (SCWT), gait analysis, foot plantar pressure test, 10-m walking test (10MWT), Berg balance scale (BBS), and timed up and go test (TUGT). In the SCWT, it was attempted to record the time of each card (SCWT-T), the correct number (SCWT-C), Stroop interference effect-time (SIE-T), and SIE correct count (SIE-C). The TUGT was categorized into four stages: getting up (GT), walking straight (WT), turning around (TT), and sitting down (ST), in which the total time of TUGT was calculated. Results: After two weeks of treatment, the evaluation indexes were improved in the two groups, some of which were statistically significant. In the experimental group, SCWT-T, SIE-T, SIE-C, GT, WT, TT, ST, and TUGT were significantly improved after treatment (p < 0.05). SCWT-C, L-FMA score, 10MWT, GT, WT, stride length, step width, foot plantar pressure, pressure center curve, and activities of daily living were not statistically different from those before treatment (p > 0.05). After treatment, SCWT-T, SIE-C, SIE-T, BBS score, TT, and ST in the experimental group were significantly shorter than those before treatment, with statistical differences (p < 0.05). Compared with the sham group, SCWT-C, L-FMA score, 10MWT, GT, WT, TUGT, stride length, step width, foot plantar pressure, pressure center curve, and motor skills were not significantly improved (p > 0.05). Conclusion: It was revealed that post-stroke rTMS treatment of patients with ED could improve executive function, improve postural control function, and reduce the risk of falling. In addition, rTMS of DLPFC could be a therapeutic target for improving postural control ability and reducing the risk of falling.
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Lombardo, Mauro, Gianluca Rizzo, Alessandra Feraco, Marco Alfonso Perrone, Chiara Bellia, Davide Lauro, Massimiliano Caprio, Alfonso Bellia, and Elvira Padua. "High plant-based diet and physical activity in women during menopausal transition." Nutrition & Food Science 52, no. 3 (October 6, 2021): 547–60. http://dx.doi.org/10.1108/nfs-06-2021-0195.
Повний текст джерелаАнотація:
Purpose The menopausal transition (MT) is a period when there may be an increase in visceral fat mass and a worsening of cardiometabolic risk factors. Few studies have evaluated the efficacy of plant-based low-calorie diets on groups of women at different stages of MT. The purpose of this study is to compare the effectiveness of a high plant-to-animal protein ratio diet in women of similar age but with different fertility statuses. Design/methodology/approach Subjects were divided into three groups according to their fertility status at the baseline: “premenopausal” (n = 11), “perimenopause” (n = 14) and “postmenopause” (n = 18). Body composition (BC) was measured at the beginning and after eight months of treatment. Individualised lifestyle treatment included a strong component of plant-based foods. Findings Forty-three overweight or obese Caucasian women (age 52.3 ± 4.5 years, body mass index 30.6 ± 5.4 kg/m2, fat mass 33.1 ± 9.3 kg data presented as means ± SD) were included in the study. Mean physical activity was 8.4 ± 7.6 metabolic equivalent of tasks/week. Subjects had an improvement in BC (fat mass −5.6 ± 4.0 kg, p < 0.001 protein −0.3 ± 0.5 kg, p < 0.001), HDL-C and systolic blood pressure values. Waist circumference and hip circumference decreased by 4.1 ± 3.1 cm and −6.0 ± 4.3 cm, respectively. Weight loss resulted in a significant improvement in some blood lipid values, such as total and high-density lipoprotein cholesterol. Adherence to a high plant protein diet helps adult women with different fertility statuses to improve BC and reduce cardiovascular risk factors. Long-term studies with larger sample sizes are needed to confirm these findings. Originality/value In pre-peri- and post-menopausal adult women, a diet high in plant proteins improves body composition and reduces cardiovascular risk factors.
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Pinto, Zulmiro. "Kajian Perilaku Masyarakat Pesisir yang Mengakibatkan Kerusakan Lingkungan (Studi Kasus di Pantai Kuwaru, Desa Poncosari, Kecamatan Srandakan, Kabupaten Bantul, Provinsi DIY)." Jurnal Wilayah dan Lingkungan 3, no. 3 (June 6, 2016): 163. http://dx.doi.org/10.14710/jwl.3.3.163-174.
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<pre style="margin-top: 0cm; margin-right: 14.15pt; margin-bottom: .0001pt; margin-left: 14.2pt; text-align: justify; tab-stops: 36.0pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt; background: white;"><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121;" lang="EN-US">A coastal area is a transition area between sea and land. The development of </span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121; mso-ansi-language: IN;">the </span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121;" lang="EN-US">coastal area is influenced by the pressure of human activities and phenomena that occur both </span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121; mso-ansi-language: IN;">on</span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121;" lang="EN-US"> land and sea. The condition is il</span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121; mso-ansi-language: IN;">l</span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121;" lang="EN-US">ustrated in the Kuwaru Beach, Bantul District. Kuwaru Beach has a unique nature mainly the pine trees and culinary. However, the behavior of people may endanger the natural condition at this area. </span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; color: #212121;" lang="EN-US">The aim of this study is to examine the behavior of coastal communities relates to the environmental damage in Kuwaru Beach and the impact on social and economic aspect. A mixed method was applied by using sequential explanatory design. Selection of the sample is completed by purposive sampling on government and fishermen groups</span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; color: #212121; mso-ansi-language: IN;">. </span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121;" lang="EN-US">The results show that the behavior of coastal communities has lead to the environment degradation and it is very influential in decreasing the welfare of society. This research also found that the people's behavior is very much influenced by the l</span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121; mso-ansi-language: IN;">ittle</span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121;" lang="EN-US"> level of education and low awareness on </span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121; mso-ansi-language: IN;">the </span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121;" lang="EN-US">coastal region of Kuwaru Beach. Local government should work together with</span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121; mso-ansi-language: IN;"> the</span></em><em style="mso-bidi-font-style: normal;"><span style="font-family: 'Amasis MT','serif'; mso-bidi-font-family: 'Times New Roman'; color: #212121;" lang="EN-US"> local community to save Kuwaru Beach from environmental damage caused by the behavior of the people themselves.</span></em><em style="mso-bidi-font-style: normal;"></em></pre>
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Betts, Juliana, Elizabeth M. Dewar, Dion Stub, Caroline X. Gao, David W. Brown, Jillian F. Ikin, Berihun M. Zeleke, Sinjini Biswas, Michael J. Abramson, and Danny Liew. "Markers of Cardiovascular Disease among Adults Exposed to Smoke from the Hazelwood Coal Mine Fire." International Journal of Environmental Research and Public Health 18, no. 4 (February 8, 2021): 1587. http://dx.doi.org/10.3390/ijerph18041587.
Повний текст джерелаАнотація:
Little research has examined the effects of high concentration, medium-duration smoke exposure on cardiovascular health. We investigated whether six weeks of exposure to smoke from the 2014 Hazelwood coal mine fire in Victoria (Australia), was associated with long-term clinical or subclinical cardiovascular disease approximately four years later, in adult residents of the towns of Morwell (exposed, n = 336) and Sale (unexposed, n = 162). The primary outcome was serum high sensitivity (hs) C-reactive protein (CRP). Blood pressure, electrocardiogram, flow mediated dilatation and serum levels of hs-troponin, N-terminal pro B-type natriuretic peptide and lipids were secondary outcomes. There was no significant difference in weighted median hsCRP levels between exposed and unexposed participants (1.9 mg/L vs. 1.6 mg/L, p = 0.273). Other outcomes were comparable between the groups. hsCRP was associated in a predictable manner with current smoking, obesity and use of lipid-lowering therapy. Four years after a 6-week coal mine fire, this study found no association between smoke exposure and markers of clinical or subclinical cardiovascular disease in exposed adults.
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Li, Xiang, Wenwu Zheng, Jinsong Li, Yibin Gao, Qiang Lin, Jinfeng Yang, Shuiying Huang, Defang Wang, and Bin Wang. "Primary Exploration of Efficacy of Community-Family Management Mode under Internet-Based Mobile Terminal Monitoring in Elderly Patients with Stable Coronary Heart Disease." Journal of Healthcare Engineering 2022 (January 25, 2022): 1–6. http://dx.doi.org/10.1155/2022/7043928.
Повний текст джерелаАнотація:
Objective. To explore the efficacy of community-family management mode under Internet-based mobile terminal (MT) monitoring in stable coronary heart disease (CHD) in the elderly. Methods. A total of 86 patients with stable CHD treated in our hospital from May 2018 to May 2021 were selected as the study objects for the retrospective study and were divided into the control group (routine intervention) and the research group (community-family management mode intervention under Internet MT monitoring) according to the health management modes, with 43 cases each, and the health behaviors and control of CHD were compared between the two groups. Results. No statistical between-group differences in general information were observed ( P > 0.05 ); 6 months after intervention, the control of laboratory indexes including blood pressure, blood glucose, triglyceride, and total cholesterol in patients was obviously better in the research group than in the control group ( P > 0.05 ); after intervention, the scores on rehabilitation knowledge level and secondary prevention behavior were obviously higher in the research group than in the control group ( P > 0.05 ); 6 months after intervention, the scores on physical limitation, anginal stabilization, anginal frequency, disease perception, and treatment satisfaction were obviously higher in the research group than in the control group ( P > 0.05 ); compared with the control group within 1 year of intervention, the readmission rate of the research group was significantly lower ( P > 0.05 ); and compared with the control group, the total score of CQQC and scores on physical strength, condition, general life, and social mentality were significantly better in the research group ( P > 0.05 ). Conclusion. Community-family management mode under Internet-based MT monitoring is the valid continuation of clinical nursing for elderly patients with stable CHD, which plays an effective role in terms of daily monitoring indexes, stabilizing condition, improving disease cognition, reducing the readmission rate, and improving the prognostic quality of life of patients.
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Farooq, Sajid, Muhammad Farhan Ali Rizvi, Sana Urooj Hashmi, Mirza Ahmad Raza Baig, Hafiz Syed Muhammad Irfan Yousaf, and Tasadduq Munir. "A prospective randomized study to see the effects of combined administration of dexmedetomidine plus propofol versus propofol alone in cardiac surgical patients." Professional Medical Journal 28, no. 04 (April 10, 2021): 447–54. http://dx.doi.org/10.29309/tpmj/2021.28.04.5815.
Повний текст джерелаАнотація:
Objective: To compare the hemodynamics changes, intraoperative awareness and postoperative delirium after combined administration of dexmedetomidine plus propofol versus propofol alone in cardiac surgical patients. Study Design: Randomized Clinical Trial. Setting: Cardiac Center, Bahawal Victoria Hospital, Bahawalpur. Period: 1st December 2018 to January 2020. Material & Methods: Sixty-two (62) patients who underwent different cardiac surgical procedures were included in the study. Patients were randomly divided in group 1 {Dexmedetomidine (DEX) +Propofol} and group 2 {propofol alone}. Induction in group 1 was done by loading dose of DEX (0.7 microgram/kg) while induction in group 2 was done by Lignocaine 1.5 mg/kg. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP) were recorded at different time intervals. Intraoperative awareness and post-operative delirium was also assessed. Results: All hemodynamic parameters (HR, SAP, DAP, MAP) were statistically significant lower in group 1 in comparison to group 2 at different intervals indicating a more stable hemodynamic profile in group 1. End tidal CO2, pH, and peak airway pressures were not statistically significant between both groups. Intra-operative awareness was diagnosed in 1 (3.2%) patients in group 1 and in 5 (16.1%) patients in group 2 (p-value 0.08). Delirium was diagnosed in 3 (9.6%) patients in group 1 and in only 1 (3.2%) patients in group 2 (p-value 0.30). Conclusion: Combined administration of DEX and propofol produces more stable hemodynamics, less intraoperative awareness but more incidence of delirium as compared to propofol alone in cardiac surgical patients.
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Vianney, Tushabe John, Duncan J. Berger, Stephen R. Doyle, Geetha Sankaranarayanan, Joel Serubanja, Prossy Kabuubi Nakawungu, Fred Besigye, et al. "Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities." PLOS Neglected Tropical Diseases 16, no. 8 (August 18, 2022): e0010188. http://dx.doi.org/10.1371/journal.pntd.0010188.
Повний текст джерелаАнотація:
Populations within schistosomiasis control areas, especially those in Africa, are recommended to receive regular mass drug administration (MDA) with praziquantel (PZQ) as the main strategy for controlling the disease. The impact of PZQ treatment on schistosome genetics remains poorly understood, and is limited by a lack of high-resolution genetic data on the population structure of parasites within these control areas. We generated whole-genome sequence data from 174 individual miracidia collected from both children and adults from fishing communities on islands in Lake Victoria in Uganda that had received either annual or quarterly MDA with PZQ over four years, including samples collected immediately before and four weeks after treatment. Genome variation within and between samples was characterised and we investigated genomic signatures of natural selection acting on these populations that could be due to PZQ treatment. The parasite population on these islands was more diverse than found in nearby villages on the lake shore. We saw little or no genetic differentiation between villages, or between the groups of villages with different treatment intensity, but slightly higher genetic diversity within the pre-treatment compared to post-treatment parasite populations. We identified classes of genes significantly enriched within regions of the genome with evidence of recent positive selection among post-treatment and intensively treated parasite populations. The differential selection observed in post-treatment and pre-treatment parasite populations could be linked to any reduced susceptibility of parasites to praziquantel treatment.
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Bradley, Matthew, Samuel Galvagno, Amit Dhanda, Carlos Rodriguez, Margaret Lauerman, Joseph Dubose, Thomas Scalea, and Deborah Stein. "Damage Control Resuscitation Protocol and the Management of Open Abdomens in Trauma Patients." American Surgeon 80, no. 8 (August 2014): 768–75. http://dx.doi.org/10.1177/000313481408000825.
Повний текст джерелаАнотація:
Although the use of damage control laparotomy (DCL) is well established, the effect of damage control resuscitation (DCR) on the management of open abdomens is relatively poorly studied. The aim of the present study was to determine the predictors for failure to achieve primary fascial closure (PFC) after DCL in the setting of a massive transfusion (MT) and DCR. This is a retrospective review over a 12-year period of all patients that underwent MT and DCL. Patients who achieved PFC were compared with those who did not (NPFC). Student's t tests were used to compare the two groups. A multiple logistic regression model was performed to identify independent risk factors for failure to attain PFC. Of 174 patients, 101 achieved PFC. Mean (6 standard deviation) age was 35.6 ± 14.9 years for PFC and 36.3 ± 14.0 years for NPFC ( P = 0.75). Admission Glasgow Coma Scale score was 11.4 ± 4.6 for PFC and 10.6 ± 5.0 for NPFC ( P = 0.25). Initial lactate (7.3 ± 3.8 vs 7.7 ± 4.1, P = 0.50), hemoglobin (11.3 ± 1.9 vs 11.0 ± 2.2, P = 0.43), systolic blood pressure (108 ± 44 vs 107 ± 35, P = 0.82), Injury Severity Score (34 ± 14 vs 36 ± 15, P = 0.32), and abdominal Abbreviated Injury Score (3.6 ± 1.1 vs 3.9 ± 1.0, P = 0.13) were similar between the two groups. There was no difference in total blood products administered at 24 hours (46 ± 26 vs 49 ± 29 units, P = 0.45). Logistic regression identified increasing volume of crystalloid at 24 hours (odds ratio, 0.86; 95% confidence interval, 0.74 to 0.99; P = 0.047), earlier operative year (2.1; 1.52 to 2.91; P < 0.001), and increased number of procedures (0.32, 0.18 to 0.58; P < 0.001) as independent predictors for failure to obtain PFC. Injury severity is not associated with failure to achieve PFC, whereas administration of large-volume crystalloid resuscitation, increasing number procedures, and earlier year of DCL are independent predictors for failure to achieve PFC. Application of DCR to DCL techniques results in an improvement in ability to achieve PFC.
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Кондратюк, В. Є., А. С. Петрова, О. В. Карпенко, Т. Г. Осташевська, and Е. К. Красюк. "Interrelation Between Disorder of Melatonin-forming Function of Epiphysis and Dyslipidemia in Patients with Chronic Kidney Disease of V Stage Treated by Hemodialysis." Family Medicine, no. 1-2 (May 21, 2020): 112–20. http://dx.doi.org/10.30841/2307-5112.1-2.2020.204585.
Повний текст джерелаАнотація:
The results of a number of studies have proved the relationship between the functional state of the pineal gland and renal function. However, violations of the melatonin-forming function of the epiphysis (MFE) in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and its relationship with dyslipidemia in this patient population is a poorly understood issue. The objective: to analyze disorders of MFE and blood lipid spectrum in patients with CKD of 5 stage treated with HD and to determine the relationship of epiphysis dysfunction with dyslipidemia. Materials and methods. 130 people (50% of men) aged 58.5 were surveyed [43; 66] which are on permanent hemodialysis treatment. Control passed 20 healthy individuals. The determination of day and night level of melatonin (MT) in saliva was conducted, based on the level of which patients (treated with HD) were divided into two groups: group I – 110 patients with impaired MFE, group II – 20 patients with normal MFE. Clinical and laboratory researches were carried out for all patients: general and biochemical analyzes of blood with determination of cholesterol level and its fractions, measurements of office blood pressure (BP) were made. Results. Significant prevalence of MFE disorders in patients with CKD of 5 stage treated with hemodialysis and its relationship with blood lipid spectrum were found. The level of total cholesterol (TC), triglycerides (TG) and low density lipoproteins (LDL) in patients with impaired MFE was higher by 26.4 % (p<0.05), 16.7 % (p<0.05) and 22,6 % (p= 0.03) according to the outcome of the comparison group patients. The level of high-density lipoprotein (HDL) of the main group is lower by 11.8 % compared to the group with preserved MFE. The data obtained indicate the relationship of MFE disorders with the duration of RRT treatment, the duration of arterial hypertension, the age of patients, and their effect on the lipid spectrum of patients with CKD of 5 stage treated with hemodialysis. Night feedback correlation of MT with TC level was established (r=–0.256; p<0.05). Correlation analysis confirms that a decrease in MT at night is combined with an increase of TG level (r=–0.272; p<0.05) in the blood of patients. The feedback correlation of night (r=–0.347; p=0.03) and daytime level (r=–0.198; p<0.05) of MT with LDL level and positive relationships between MT in daytime (r=0.27; p=0.03) and the night period (r=0.331; p=0.02) with HDL levels. Conclusion. For patients with CKD of 5 stage undergoing hemodialysis, there is a frequent violation of MFE (84.6%) and significant disorders of lipid metabolism (58%). Analysis of the lipid metabolism study revealed more profound abnormalities in the form of an increased concentration of TC and all its fractions in patients with impaired MFE, which may indicate a connection between epiphysis dysfunction and lipid metabolism in patients with RRT. In patients with hemodialysis, melatonin-forming dysfunction and disorders of lipid metabolism are age-dependent and are determined by the duration of RRT, the duration of hypertension, the level of hemoglobin. We have identified a relationship between the deterioration of lipid metabolism on the background of deeper disturbance of MFE by daytime and nighttime MT.
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Salviulo, Gabriella, Luciano Secco, Paolo Antonini, and Enzo Michele Piccirillo. "C2/c pyroxene from two alkaline sodic suites (Western Ross Embayment – Antarctica): crystal chemical characterization and its petrologic significance." Mineralogical Magazine 61, no. 406 (June 1997): 423–39. http://dx.doi.org/10.1180/minmag.1997.061.406.08.
Повний текст джерелаАнотація:
AbstractTwo C2/c pyroxene suites from sodic alkaline rocks (Basanite-Phonolite: B-Ph and Alkali basalt-Trachyphonolite: AB-T) belonging to the McMurdo Volcanic Group (Mt. Melbourne province and Mt. Erebus, Antarctica) were investigated by single-crystal X-ray diffraction combined with electron probe microanalysis which together provide accurate site occupancy and site configuration parameters. Variations in site volumes distinguish the clinopyroxenes belonging to the more alkaline B-Ph suite from those of the AB-T suite. The former have higher VM2 and, for similar cell volume, lower VM1 and higher VT. In these C2/c pyroxenes, the bond lengths of M1 depend on R3+ content, necessary to balance AlIV in the T site. M1 geometric variations are similar for both B-Ph and AB-T suites. However, the M2 site is crucial for variations in polyhedral configurations. The increase in AlIV affects the shortest M2-O bond lengths in different ways depending on (Ca+Na) contents in the M2 site. Thus, the clinopyroxenes were distinguished in two different groups not related to the two suites. The first group is characterized by (Ca+Na) higher than 0.90 atoms per formula unit but shows a good positive correlation between the shortest M2-O bond lengths and AlIV content, at quite constant (Ca+Na). The second group has (Ca+Na) less than 0.90 atoms per formula unit but shows a poor correlation between the shortest M2-O bond lengths and AlIV content. In general, shortening of the longest M2-O bond lengths is associated with increase in AlIV. The cell and M1 volumes suggest that the clinopyroxenes, including the larger and sometimes resorbed macrocrysts, crystallized at a pressure lower than 5 kbar, fitting the petrography and evolved character of the rocks in question.
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Li, Peng, Xiao-Min Liu, Li Wang, Zhao-Jiang Du, and Qian-Yan Kang. "Clinical research of EX-PRESS drainage device and modified trabeculectomy combined with intravitreal conbercept treatment for neovascular glaucoma." International Journal of Ophthalmology 15, no. 2 (February 18, 2022): 242–47. http://dx.doi.org/10.18240/ijo.2022.02.08.
Повний текст джерелаАнотація:
AIM: To evaluate the efficacy and safety of modified trabeculectomy (experimental group) and implantation of EX-PRESS drainage device (control group), combined with intravitreal conbercept injection for neovascular glaucoma (NVG). METHODS: Totally 30 patients with NVG were selected from June 2014 to June 2017, and randomly divided into experimental group and control group. All patients were underwent intravitreal conbercept (0.5 mg/0.05 mL) treatment before surgery. Modified trabeculectomy was performed in MT group, while EX-PRESS drainage device implantation was performed in EX group. The success rates, best corrected visual acuity (BCVA), intraocular pressure (IOP), filtering bleb and complications were observed and compared. RESULTS: The differences of success rate, BCVA and filtering bleb were not statistically significant 12mo after the surgery (P&#x003E;0.05), however, the difference of IOP at 1d, 1wk, 1, 3, and 6mo after surgery was statistically significant (Ftime=390.64, Ptime&#x003C;0.0001) between two groups. The interactions between two groups in the given time showed no significant difference (Fintergroup×time=0.181, Pintergroup×time=0.57), and also there was no significant difference in IOP between the two groups (F=3.16, P=0.09). The results of pairwise comparison at each time point showed no significant difference in IOP between 1d and 1wk, 3 and 6, 3mo and 12mo after surgery (P&#x003E;0.05), while the results at other time point indicate statistical differences (P&#x003C;0.05). CONCLUSION: The modified trabeculectomy and the implantation of EX-PRESS drainage device have clinical application value in reducing IOP and postoperative complications of refractory NVG.