Статті в журналах: "Predisposition to depression"

1

Sandler, M., Vivette Glover, and Patricia Hannah. "Postnatal depression: Predisposition and prediction." Journal of Obstetrics and Gynaecology 10, no. 3 (January 1990): 238–39. http://dx.doi.org/10.3109/01443619009151181.

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Beatson, Josephine, and Suzanna Taryan. "Predisposition to Depression: The Role of Attachment." Australian & New Zealand Journal of Psychiatry 37, no. 2 (April 2003): 219–25. http://dx.doi.org/10.1046/j.1440-1614.2003.01126.x.

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Objective: To examine the hypothesis that adverse early relational experiences causing activation of the hypophysial-pituitary-adrenal (HPA) axis during critical early stages of development can predispose to depression. Patients thus affected are likely to manifest insecure patterns of attachment in close relationships and are vulnerable to depression after adverse life events. Method: The literature pertaining to sensitization of the HPA axis in early life and the neurobiology of attachment is examined. Results: Adverse early relational experiences can result in activation of the HPA axis, causing sensitization of depression pathways in the brain. Secure attachment acts as a buffer against HPA activation in response to stress. Infants with insecure attachment lack this buffering effect and may be predisposed to depression and other psychiatric disorders in response to psychosocial stressors. Conclusions: There is a patient group predisposed to depression on the basis of adverse early life experience. In these cases, the neurobiology of attachment offers a means of integrating findings concerning sensitization of the HPA axis in infancy, the effects of early life experience on brain development, and predisposition to depression and other psychiatric disorders. These findings have important implications for the development of interventions aimed at prevention and treatment for this patient group.

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Knyazev, Gennady G., Andrey V. Bocharov, Alexander N. Savostyanov, and Jaroslav Slobodskoy-Plusnin. "Predisposition to depression and implicit emotion processing." Journal of Clinical and Experimental Neuropsychology 37, no. 7 (July 24, 2015): 701–9. http://dx.doi.org/10.1080/13803395.2015.1061483.

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4

Martin, Maryanne. "Neuroticism as predisposition toward depression: A cognitive mechanism." Personality and Individual Differences 6, no. 3 (January 1985): 353–65. http://dx.doi.org/10.1016/0191-8869(85)90060-1.

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5

McGuffin, Peter, and Randy Katz. "The Genetics of Depression and Manic-Depressive Disorder." British Journal of Psychiatry 155, no. 3 (September 1989): 294–304. http://dx.doi.org/10.1192/bjp.155.3.294.

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Depressive disorders are more common in the relatives of depressed probands than in the population at large, and there is compelling evidence that the familial aggregation of bipolar disorder and severe unipolar depression is at least partly due to genetic factors. However, the evidence concerning ‘non-endogenous' depression is less clear, and family environment probably plays a stronger role. Much current research is focused on two areas: firstly, the mode of inheritance of manic-depressive illness, with the use of molecular biological techniques to detect and localise major genes; and secondly, the ways in which familial predisposition and environmental insults combine to produce depressive disorder.

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6

Ferrier, I. N. "Comparisons of Clinical Efficacy." British Journal of Psychiatry 163, S20 (July 1993): 25–28. http://dx.doi.org/10.1192/s0007125000292337.

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This paper does not attempt to review the whole topic of clinical efficacy but will consider general concepts, particularly in the light of the advent of the serotonin (5-HT) uptake inhibitors (SSRIs).The aetiology of depression is complex. In most cases there is some form of predisposition based on problematical family dynamics, disordered family communication and/or genetic factors; each may be present to a variable extent. On top of this predisposition, some form of stimulus - ‘stress’, an external problem, loss of control, a physical disorder, adverse life circumstances - appears to affect those who are already primed. There are a variety of possible outcomes from this combination of predisposition and stimuli: low mood, depression in the full syndromic sense, and depression with biological features. It seems likely that, particularly with severe depressions (the major syndromic forms and those with biological features), there are neuroendocrine and neurochemical changes to mediate the effects of stress into those of the clinical symptoms and signs. It has been hypothesised that stressors induce adaptive neurochemical changes, failure of which may engender behavioural disturbances (Anisman & Zacharko, 1992). However, there are also many individuals who may not undergo this process, but who probably have some cognitive or learned change leading to dysphoria; this aspect needs to be considered carefully in relation to efficacy.

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7

Fatima, Rida, and Alishba Hania. "PREDISPOSITION OF EARLY MALADAPTIVE SCHEMAS AND POSTPARTUM DEPRESSION DURING COVID-19 CRISIS: MEDIATION OF MINDFULNESS." PSYCHIATRIA DANUBINA 34, no. 1 (April 22, 2022): 148–56. http://dx.doi.org/10.24869/psyd.2022.148.

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8

Shnayder, Natalia A., Maxim A. Novitsky, Nikolay G. Neznanov, Oleg V. Limankin, Azat R. Asadullin, Artem V. Petrov, Diana V. Dmitrenko, Ekaterina A. Narodova, Natalia V. Popenko, and Regina F. Nasyrova. "Genetic Predisposition to Schizophrenia and Depressive Disorder Comorbidity." Genes 13, no. 3 (March 2, 2022): 457. http://dx.doi.org/10.3390/genes13030457.

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Background: Patients with schizophrenia have an increased risk of depressive disorders compared to the general population. The comorbidity between schizophrenia and depression suggests a potential coincidence of the pathophysiology and/or genetic predictors of these mental disorders. The aim of this study was to review the potential genetic predictors of schizophrenia and depression comorbidity. Materials and Methods: We carried out research and analysis of publications in the databases PubMed, Springer, Wiley Online Library, Taylor & Francis Online, Science Direct, and eLIBRARY.RU using keywords and their combinations. The search depth was the last 10 years (2010–2020). Full-text original articles, reviews, meta-analyses, and clinical observations were analyzed. A total of 459 articles were found, of which 45 articles corresponding to the purpose of this study were analyzed in this topic review. Results: Overlap in the symptoms and genetic predictors between these disorders suggests that a common etiological mechanism may underlie the presentation of comorbid depression in schizophrenia. The molecular mechanisms linking schizophrenia and depression are polygenic. The most studied candidate genes are GRIN1, GPM6A, SEPTIN4, TPH1, TPH2, CACNA1C, CACNB2, and BCL9. Conclusion: Planning and conducting genome-wide and associative genetic studies of the comorbid conditions under consideration in psychiatry is important for the development of biological and clinical predictors and a personalized therapy strategy for schizophrenia. However, it should be recognized that the problems of predictive and personalized psychiatry in the diagnosis and treatment of schizophrenia and comorbid disorders are far from being resolved.

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Abkevich, Victor, Nicola J. Camp, Charles H. Hensel, Chris D. Neff, Deanna L. Russell, Dana C. Hughes, Agnes M. Plenk, et al. "Predisposition Locus for Major Depression at Chromosome 12q22-12q23.2." American Journal of Human Genetics 73, no. 6 (December 2003): 1271–81. http://dx.doi.org/10.1086/379978.

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10

Willner, P., and P. J. Mitchell. "The validity of animal models of predisposition to depression." Behavioural Pharmacology 13, no. 3 (May 2002): 169–88. http://dx.doi.org/10.1097/00008877-200205000-00001.

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11

Lebowitz, Matthew S., and Woo-kyoung Ahn. "Testing positive for a genetic predisposition to depression magnifies retrospective memory for depressive symptoms." Journal of Consulting and Clinical Psychology 85, no. 11 (November 2017): 1052–63. http://dx.doi.org/10.1037/ccp0000254.

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12

Enns, Murray W., and Brian J. Cox. "Personality Dimensions and Depression: Review and Commentary." Canadian Journal of Psychiatry 42, no. 3 (April 1997): 274–84. http://dx.doi.org/10.1177/070674379704200305.

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Objectives The relationship between dimensionally assessed personality and the onset, features, and course of depressive illness will be critically examined and considered in relation to 4 hypothesized models: predisposition or vulnerability; pathoplasty; complication or scar; and spectrum or continuity. Method Studies that have used clinically depressed adult patients to explore the relationship between personality dimensions and depression will be reviewed. Results Higher-order personality factors that have shown a significant and consistent association with major depressive illness include neuroticism, extraversion (negative relationship), and the factors of Cloninger's Tridimensional Personality Model. Neuroticism appears to be the most powerful predictor of depression. Lower-order factors showing a significant and consistent relationship with depressive illness include dependency, self-criticism, obsessionality, and perfectionism. The links between depression and dependency and self-criticism have the strongest empirical support. Conclusions Several personality dimensions are significantly associated with depressive illness, but the evidence that unequivocally demonstrates a true personality predisposition for depression is modest. Measures of personality may prove to be clinically useful for treatment selection.

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13

Braithwaite, E. C., S. E. Murphy, and P. G. Ramchandani. "Prenatal risk factors for depression: a critical review of the evidence and potential mechanisms." Journal of Developmental Origins of Health and Disease 5, no. 5 (June 20, 2014): 339–50. http://dx.doi.org/10.1017/s2040174414000324.

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Exposure to adverse experiences in early life increases the risk of depression during adulthood. Recent findings have highlighted that exposure of a fetus to an adverse intrauterine environment may also have implications for later offspring depression. This review considers the status of the evidence for these associations and the potential mechanisms underlying prenatal developmental risks for later depression, addressing the challenging possibility that environmental predisposition to depression may begin before birth.

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14

Scherer, Marcia J., and Laura A. Cushman. "Predicting Satisfaction with Assistive Technology for a Sample of Adults with New Spinal Cord Injuries." Psychological Reports 87, no. 3 (December 2000): 981–87. http://dx.doi.org/10.2466/pr0.2000.87.3.981.

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To assess the validity of the Assistive Technology Device Predisposition Assessment-Consumer Form for persons with a new spinal cord injury, 10 men and 10 women completed the scale and the Satisfaction with Life Scale and the Brief Symptom Inventory while in acute rehabilitation. One month postdischarge, subjects completed the Perceived Needs Inventory and rated their satisfaction with assistive technology. Significant positive correlations between items of the Assistive Technology Device Predisposition Assessment and Satisfaction with Life Scale (and their significant negative correlations with scores on the Brief Symptom Inventory–Depression) suggest the selected Assistive Technology Device Predisposition Assessment items measure quality of life (concurrent validity) Only Assistive Technology Device Predisposition Assessment scores predicted satisfied use 1-mo. postdischarge as measured by the Perceived Needs Inventory.

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15

Van Vort, Walter B., Margot Rubenstein, and Robert P. Rose. "Osteoporosis With Pathologic Hip Fractures in Major Depression." Journal of Geriatric Psychiatry and Neurology 3, no. 1 (January 1990): 10–12. http://dx.doi.org/10.1177/089198879000300103.

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Osteoporosis and its sequelae have been associated with genetic predisposition, aging, nutritional factors, inactivity, substance abuse, and anorexia nervosa. We report three cases of pathologic osteoporotic hip fractures in elderly females with major depression. Biological consequences of depression and mobilization during hospital treatment are discussed as possible mediators of osteoporotic morbidity. ( J Geriatr Psychiatry Neurol 1990;3:10-12).

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Audrain-McGovern, Janet, Caryn Lerman, E. Paul Wileyto, Daniel Rodriguez, and Peter G. Shields. "Interacting Effects of Genetic Predisposition and Depression on Adolescent Smoking Progression." American Journal of Psychiatry 161, no. 7 (July 2004): 1224–30. http://dx.doi.org/10.1176/appi.ajp.161.7.1224.

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17

Jensen, P. S. "Interacting Effects of Genetic Predisposition and Depression on Adolescent Smoking Progression." Yearbook of Psychiatry and Applied Mental Health 2006 (January 2006): 17–18. http://dx.doi.org/10.1016/s0084-3970(08)70019-7.

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18

Blau, Gary M., Janet F. Gillespie, Robert D. Felner, and Elizabeth G. Evans. "Predisposition to Drug Use in Rural Adolescents: Preliminary Relationships and Methodological Considerations." Journal of Drug Education 18, no. 1 (March 1988): 13–22. http://dx.doi.org/10.2190/mpjg-kpvb-x1w9-2uvv.

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This study was designed to determine whether there was a relationship between self-esteem, depression, and anxiety, and drug abuse. Specifically, it was found that self-esteem, depression, and anxiety were significantly correlated with variables associated with potential drug use (attitudes toward drugs and willingness to use drugs). In contrast to previous work, which used a post hoc methodology, this research focused on a sample that reported no prior experience with drugs and alcohol. Possible implications of these findings and guidelines for future research are discussed.

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19

Hengartner, M. P., V. Ajdacic-Gross, C. Wyss, J. Angst, and W. Rössler. "Relationship between personality and psychopathology in a longitudinal community study: a test of the predisposition model." Psychological Medicine 46, no. 8 (March 16, 2016): 1693–705. http://dx.doi.org/10.1017/s0033291716000210.

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BackgroundMounting evidence supports the notion that personality is crucial in the aetiopathology of common mental disorders, but studies that allow for aetiological conclusions are lacking. The aim of the present study was thus to provide a test of the predisposition model.MethodWe analysed data from the Zurich Cohort Study, a 30-year longitudinal epidemiological community study of an adult cohort (n = 591) from 1979 to 2008. Personality was assessed in 1988 with an established personality questionnaire, and psychopathology through seven semi-structured interviews between 1979 and 2008.ResultsOn the basis of personality assessment from 1988, used as predictor of subsequent psychopathology (1993–2008), while adjusting for sex and prior mental disorders (1979–1988), neuroticism related significantly with future major depression episodes [odds ratio (OR) = 1.41], anxiety disorders (OR = 1.32) and depression treatment use (OR = 1.41). When participants with a past 10-year history (i.e. 1979–1988) of either major depression, anxiety disorder or depression treatment use were excluded, neuroticism in 1988 still significantly predicted first incidence (i.e. 1993–2008) of major depression episodes (OR = 1.53) and depression treatment use (OR = 1.84).ConclusionsThe present study provides compelling evidence that the personality trait of neuroticism constitutes an independent risk factor for subsequent major depression episodes and use of respective professional treatments, which serves as a proxy for particularly severe and impairing depression episodes. We therefore advocate that personality traits could provide clinically useful prognostic information when considered carefully.

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Shoukry, Heba Samy. "Depression and its Association with Vitamin D Deficiency: A Review." BioScientific Review 2, no. 4 (December 15, 2020): 34–42. http://dx.doi.org/10.32350/bsr/2020/24/1084.

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Depression is a common psychological disorder and a major health issue. Many socioeconomic, environmental and genetic factors contribute to the onset and progression of depression. In recent years, the deficiency of vitamin D has emerged as a possible predisposing factor responsible for the manifestation of depression. In this review article, the causes of depression are briefly reviewed with a special focus on the association between vitamin D and depression. In recent years, the association between vitamin D and depression has been extensively investigated; still, the mechanism that governs this association is not fully understood. An understanding of the underlying biological processes and mechanisms through which vitamin D exerts its role will help in understanding the predisposition towards depression and the amelioration of depressive symptoms.

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Shoukry, Heba Samy. "Depression and its Association with Vitamin D Deficiency: A Review." BioScientific Review 2, no. 4 (December 15, 2020): 34–42. http://dx.doi.org/10.32350/bsr.0204.04.

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Depression is a common psychological disorder and a major health issue. Many socioeconomic, environmental and genetic factors contribute to the onset and progression of depression. In recent years, the deficiency of vitamin D has emerged as a possible predisposing factor responsible for the manifestation of depression. In this review article, the causes of depression are briefly reviewed with a special focus on the association between vitamin D and depression. In recent years, the association between vitamin D and depression has been extensively investigated; still, the mechanism that governs this association is not fully understood. An understanding of the underlying biological processes and mechanisms through which vitamin D exerts its role will help in understanding the predisposition towards depression and the amelioration of depressive symptoms.

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Majumder, Irina, Jason M. White, and Rodney J. Irvine. "Antidepressant‐like effects of ecstasy in subjects with a predisposition to depression." Addictive Behaviors 37, no. 10 (October 2012): 1189–92. http://dx.doi.org/10.1016/j.addbeh.2012.05.022.

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23

Surkova, Ye V., M. Yu Drobizhev, O. G. Melnikova, T. A. Zakharchuk, and I. I. Dedov. "Diabetes mellitus and concomitant depressions." Problems of Endocrinology 49, no. 6 (December 15, 2002): 11–16. http://dx.doi.org/10.14341/probl11746.

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The fact that there is a high prevalence of depressions among patients with diabetes mellitus (DM) is well known. However, the relationships between the nosological entities of depressions and the clinical characteristics of DM are little studied. The study was undertaken to search for such relationships. A hundred and fifty outpatients with DM (out of them 38 males, Type 2 DM was diagnosed in 102 patients) the median age was 54.0 years (25 and 75 percentiles: 43.0-61.5), the median duration of diabetes was 7.2years (2.0-15.0); the median level of HbAlc was 8.6% (7.49.7%). Depression was revealed in 50 (33%) patients. Their comparison with patients without depression indicated that there was no association with the main clinical characteristics of MD (the type and duration of the disease, the prevalence of acute and chronic complications, insulin therapy). At the same time, a comparison of three groups of patients with the major clinical forms (nosogenic, cyclothymic, and dysthymic) of diagnosed depression by using x2 revealed the following associations: between DM-1 and cyclothymic depression and between DM-2 and nosogenic and dysthymic depression (р = 0.01). Cyclothymic and dysthymic depression showed no associations with clinical characteristics of DM. The prevalence of nosogenic depression was significantly higher in patients with a history of second-three grade diabetic retinopathy (p = 0.02), arterial hypertension (p = 0.001), proteinuria (p = 0.02), myocardial infarction (p = 0.04), and foot ulcerative defects (p = 0.04). The results show that nosogenic depression are mental responses to the severe course of DM, namely to the severity of micro- and macrovascular complications. The associations between the types of DM and the clinical types of depression -cyclothymia and dysthymia - await further study. Overall general predisposition may be discussed as a possible explanation.

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Kouros, J., D. Kotta, and R. Tsochandari. "Clinical results of a scientific medical association - therapeutic center (A.P.P.A.C.) during the last two years (2007 – 2009)." European Psychiatry 26, S2 (March 2011): 314. http://dx.doi.org/10.1016/s0924-9338(11)72023-5.

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IntroductionThe A.P.P.A.C. has created, through years, a significant data base of clinical results derived from the systematic approach of a wide range of psychiatric diseases. The aim of this study was to evaluate the current state of psychiatric diseases and associated parameters with social impact.MethodData was obtained from the Association of Psychology & Psychiatry for Adults & Children (A.P.P.A.C.) from January 2007 until December 2009. A sample N = 219 patients has been studied during the last 2 years. The mean age of patients was 35 years. Statistic analysis is based on z-criterion as well as X2-test.ResultsP-values of 0.05 were considered to be statistically significant. 20% of the patients were diagnosed with 2 psychiatric diseases, 70% of widowers have been suffered from depression. 37,84% of patients with depression have hereditary predisposition. Therapeutic interventions to patients were made using psychotherapy, medication or both. The analogy of psychotherapy to medication is almost 1:2, while in 18.75% of the patients, who needed drug treatment, psychotherapy was mandatory. Finally, our study indicated that sex (females versus males) and hereditary predisposition are significant factors for depression in comparison to other psychiatric diseases.

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Duffy, Anne. "From predisposition to illness: genetically sensitive intermediate pathways to mood disorders." British Journal of Psychiatry 197, no. 5 (November 2010): 341–42. http://dx.doi.org/10.1192/bjp.bp.110.079665.

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SummaryThe contemporary model of mood disorders proposes that multiple susceptibility genes interact with multiple other risk factors. However, the specific nature of the genetic vulnerability and the intermediate causal pathways are not known. In this edition of the Journal, Goodyer and colleagues report new findings suggesting genetic moderation of an association between elevated cortisol and depression in high-risk adolescents.

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Almeida, Ana Margarida Pisco, Margarida Figueiredo-Braga, and Hugo Almeida. "Patient-Physician Communication in Depression." International Journal of E-Services and Mobile Applications 13, no. 2 (April 2021): 73–89. http://dx.doi.org/10.4018/ijesma.2021040105.

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Optimizing clinical communication between patients and health professionals is a major demand, particularly in mental health; the use of digital media is creating new opportunities in this field. Messaging services can be particularly useful to enhance communication with patients with depression, between consultations, allowing the delivery of supportive messages or reminders. This paper discusses this scenario and describes a four-stage study: (1) a diagnosis of perspectives and practices, (2) a six-week SMS intervention plan, (3) a prototype of a digital application to support patients' follow-up and interaction, (4) and a survey on physicians' digital experience and predisposition to use the prototype. Results underline the potential of using messaging systems to improve communication between health professionals and patients with depression, namely when these systems are part of blended-interventions. Further research is needed, particularly regarding the adjustment of these solutions to specific target groups.

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Deaner, Stephanie L., and Jasmin T. McConatha. "The Relation of Humor to Depression and Personality." Psychological Reports 72, no. 3 (June 1993): 755–63. http://dx.doi.org/10.2466/pr0.1993.72.3.755.

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The present study focused on an assessment of humor, depression, and personality. 38 male and 91 female college students responded to five self-report questionnaires, i.e., Martin and Lefcourt's Situational Humor Response Questionnaire and Coping Humor Scale, Svebak's Sense of Humor Questionnaire, Zimmerman's Inventory to Diagnose Depression, and the Eysenck Personality Inventory. Analysis indicated that individuals who scored lower on the depression scale tended to score higher on the Coping Humor Scale, Extraversion, and Neuroticism. Also, individuals scoring higher on the humor scales tended to score higher on Extraversion and Emotional Stability. These personality factors appear to be strongly related to the sense of humor construct and depression. Perhaps the personality factors of introversion and neuroticism may be employed to identify a predisposition toward depression.

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Potter, W. Z., and H. K. Manji. "Catecholamines in depression: an update." Clinical Chemistry 40, no. 2 (February 1, 1994): 279–87. http://dx.doi.org/10.1093/clinchem/40.2.279.

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Abstract Despite extensive research, the biochemical abnormalities underlying the predisposition to and the pathogenesis of affective disorders remain to be clearly established. Efforts to study norepinephrine (NE) output and function have utilized biochemical assays, neuroendocrine challenge strategies, and measures of peripheral blood cell receptors; the cumulative database points to a dysregulation of the noradrenergic system. Depressed patients (in particular, melancholic, unipolar subjects) excrete disproportionately greater amounts of NE and its major extraneuronal metabolite, normetanephrine, than do controls. Depressed patients also show subsensitive neuroendocrine (growth hormone) and biochemical (inhibition of adenylate cyclase) responses to alpha 2-adrenergic agonists, suggesting that subsensitivity of nerve terminal alpha 2 autoreceptors may underlie the exaggerated plasma NE observed in response to various challenges in affective disorders. Future advances in brain imaging techniques and in the molecular biology of adrenergic receptor-coupled signal transduction systems offer promise for meaningful advances in our understanding of the pathophysiology of affective disorders.

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Morrison, Anthony P., Jacqueline Peyton, and Sarah Nothard. "Beliefs about depression and anti-depressive behaviour: relationship to depressed mood and predisposition to mania in non-patients." Personality and Individual Differences 35, no. 7 (November 2003): 1601–13. http://dx.doi.org/10.1016/s0191-8869(02)00383-5.

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Taghavi, Ebrahim. "Premenstrual Syndrome in Three Generations Responds to Antidepressants." Australian & New Zealand Journal of Psychiatry 24, no. 2 (June 1990): 276–79. http://dx.doi.org/10.3109/00048679009077693.

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The author identified the clinical picture of 11 patients with premenstrual complaint in a genealogical tree spanning three generations. Seven patients who satisfied criteria for premenstrual syndrome (PMS) were treated successfully with amitriptyline. The possible role of antidepressant treatment for PMS is discussed. The possibility is raised of genetic predisposition in some subtypes of PMS, particularly those in which depression is a feature.

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Amaltinga, Awuni Prosper Mandela, and James Fenibe Mbinta. "Factors associated with depression among young people globally: a narrative review." International Journal Of Community Medicine And Public Health 7, no. 9 (August 28, 2020): 3711. http://dx.doi.org/10.18203/2394-6040.ijcmph20203949.

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Although depression is a major concern for global health, understanding of this phenomenon has been limited since most of the empirical studies address personal characteristics without much consideration to larger environmental contexts for adolescents globally. The objective was to review factors associated with depression among young people. The researchers adopted a narrative review of selected peer reviewed articles on depression with a focus on the factors associated with depression among young people. The papers were selected according to the six World Health Organization (WHO) regions. The results show that females were at greater risk of depression compared to their male counterparts. Also, genetic predisposition as a result of maternal rumination was a factor for depression among young people in all WHO regions. Past history of depressive symptoms, uncontrollable negative life events, and family-related stressful events contributed significantly to depression among young people. Finally, the study recommends that mental health services at primary healthcare level be prioritized in all Low and Middle-Income countries (LMICs) to help identify and handle early cases of mental health in young people.

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I.M., Vizniuk. "PSYCHOLOGICAL DETERMINANTS OF SUCCESS DURING TEACHING STUDENTS WITH A TENDENCY TO DEPRESSION." Scientic Bulletin of Kherson State University. Series Psychological Sciences, no. 1 (April 15, 2021): 66–74. http://dx.doi.org/10.32999/ksu2312-3206/2021-1-9.

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The aim of our study was to identify the psychological determinants of success in teaching students with a predisposition to depression. In order to obtain results, we used such techniques as the A. Beck questionnaire, which was aimed at determining the level of predisposition to depression, the method of diagnosing personality motivation for the success of T. Ehlers, the method for determining the type of accentuation of character and temperament K. Leonhard and calculation of determining the average score of annual grades, to determine the school performance of adolescents. According to the results of the article, using the SPSS program, it was found that there is no relationship between the level of predisposition to depression and the types of character accentuation, but there is a relationship between the types of accentuation. There is also no link between the level of depression and school performance, but there is a relationship between the level of motivation to succeed and school performance.Adolescent depression can be both a consequence and a cause of school failure of students, because adolescence is a very difficult period in a person's life. As a result, the presence of depressive symptoms can affect the school system of students, their success, relationships with teachers and peers. Ignoring these symptoms and correcting them in time can lead to serious consequences, ranging from serious mental disorders to suicide. Fatalities are rare, but very dangerous, but the failure of students with a predisposition to depression during training is quite numerous and relevant today.Conclusions. Psychological determinants such as character accentuations are of great importance in motivating adolescents with a tendency to depression and academic success, because they can suppress the activity of the individual and affect his motivational sphere. However, the correlation analysis showed the presence of statistically significant relationships between the types of accentuation of adolescent character, namely between emotional, stuck, anxious, cyclothymic, unbalanced, dysthymic, exalted, meticulous, demonstrative. And the relationship between the level of motivation for success and school performance of adolescents.Key words: adolescents with a tendency to depression, academic performance, motivational sphere of personality, character accentuations, psychological determinants. Метою нашого дослідження було виявити психологічні детермінанти успішності під час навчання учнів зі схильністю до депресії. Для того щоб отримати результати, ми використовували такі методики,як опитувальник А. Бека, який спрямований на визначення рівня схильності до депресії, методика діагностики особистості на мотивацію до успіху Т. Елерса, методика для визначення типу акцентуації рис характеру та темпераменту К. Леонгарда та розрахунок визначення середнього балу річних оцінок для визначення шкільної успішності підлітків. За результатами статті, використовуючи програму SPSS, було встановлено, що не існує взаємозв’язку між рівнем схильності до депресії та типами акцентуації характеру, але існує взаємозв’язок між самими типами акцентуації. Також з’ясовано відсутність зв’язку між рівнем схильності до депресії та шкільною успішністю, але при цьому існує зв’язок між рівнем мотивації до успіху та шкільною успішністю.Підліткова депресія може бути як наслідком, так і причиною шкільної неуспішності учнів, адже підлітковий вік є досить складним періодом у житті людини. В результаті цього наявність депресивних ознак може накладати відбиток у системі шкільного навчання учнів, на їх успішність, на взаємини з учителями та однолітками. Ігнорування цих ознак та їх невчасне коригування може призвести до серйозних наслідків, починаючи від серйозних психічних розладів і закінчуючи самогубством. Летальні випадки є рідкими, проте дуже небезпечними, а от неуспішність учнів зі схильністю до депресії під час навчання є досить численною і актуальною у наш час.Висновки. Отже,велике значення у мотивації підлітків зі схильністю до депресії та успішністю до навчання мають такі психологічні детермінанти, як акцентуації характеру, адже вони можуть пригнічувати активність особистості і впливати на її мотиваційну сферу. Однак кореляційний аналіз показав наявність статистично значущих зв’язків між типами акцентуації характеру підлітків, а саме між емотивним, застрягаючим, тривожним, циклотимним, неврівноваженим, дистимічним, екзальтованим, педантичним, демонстративним; та взаємозв’язок між рівнем мотивації до успіху та шкільною успішністю підлітків.Ключові слова: підлітки зі схильністю до депресії, успішність до навчання, мотиваційна сфера особистості, акцентуації характеру, психологічні детермінанти.

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Pikulicka, Agata, Katarzyna Pacek, Małgorzata Piekarska, Radosław Kasperski, Klaudia Jedlina, Izabela Szulc, and Weronika Swacha. "Depression development in patients with celiac disease." Journal of Education, Health and Sport 13, no. 2 (December 7, 2022): 19–24. http://dx.doi.org/10.12775/jehs.2023.13.02.002.

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Due to the increasing number of patients suffering from celiac disease (CD) and difficulties in diagnosing, scientists raise awareness of different symptoms that patients might present. CD is an autoimmune, genetical disease of small intestine however, symptoms might be related to many different systems apart from gastrointestinal one, for instance nervous system. A common and non-specific symptom of untreated CD might be depression. A gluten intake by patients with genetical predisposition results in antibodies production which can affect central nervous system causing depression. Moreover, we observe imbalance between amino acids and its metabolites, for example serotonin, which lead to mood disorder. In those patients who suffer from drug-resistant depression, testing for CD should be done and if they are positive, the patient should immediately start a gluten-free diet. This action could reduce symptoms of depression. The following article is a review of current knowledge related to correlation between CD and depression, its pathomechanism and gluten-free diet as a possible way of treatment. This article is based on available publications in Pubmed and Google Scholar databases.

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Heath, Andrew C., Lindon J. Eaves, Katherine M. Kirk, and Nicholas G. Martin. "Effects of lifestyle, personality, symptoms of anxiety and depression, and genetic predisposition on subjective sleep disturbance and sleep pattern." Twin Research 1, no. 4 (August 1, 1998): 176–88. http://dx.doi.org/10.1375/twin.1.4.176.

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AbstractThe effects on sleep pattern (‘short-sleep’ versus ‘long-sleep’) and subjective sleep disturbance of genotype, personality, symptoms of anxiety and depression, and lifestyle, were examined using survey data on a clinically unselected sample of adult Australian twin pairs, aged 17–88 years. When the effects of genotype, personality and symptoms were ignored, lifestyle variables appeared to account for roughly 4% of the variance in sleep disturbance, and 9% of the variance in sleep pattern. Significant genetic effects on sleep disturbance and sleep pattern were found, which were only partly explained by the effects of personality and symptoms of anxiety and depression. Much of the association between sleep disturbance and lifestyle appeared to be explained by separate effects of personality and symptoms of anxiety and depression on sleep and lifestyle (‘genotype – risk-factor correlation’). There was little evidence for genetically determined differences in sensitivity to the lifestyle variables (‘genotype × risk-factor interaction’).

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El Hage, W., J. F. Powell, and S. A. Surguladze. "Vulnerability to depression: what is the role of stress genes in gene × environment interaction?" Psychological Medicine 39, no. 9 (February 12, 2009): 1407–11. http://dx.doi.org/10.1017/s0033291709005236.

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Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic–pituitary–adrenal (HPA) systems. We follow the standpoint of a previous Editorial Review (Bhagwagar & Cowen, Psychological Medicine 2008, 38, 307–313) and consider another possible mechanism of vulnerability to depressive disorder, that is we suggest that the gene×environment interaction involves complex participation of serotonergic genes modulating response to stress through the HPA system.

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Mermer, Meltem, and Nevin Şanlıer. "Correlation between postpartum depression and omega-3, micronutrients." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 11 (October 28, 2017): 4737. http://dx.doi.org/10.18203/2320-1770.ijrcog20174979.

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In recent years, attention has been called to the link between nutrition and mental health. Postpartum depression is an important depressive disorder which often arises 6 to 12 weeks after giving birth and can happen at any time within one year. Postpartum depression prevalence is around 20% worldwide. Genetic predisposition and environmental factors, as well as certain social, psychological and biological factors constitute risk factors for postpartum depression. While malnutrition is among the biological factors, there is a correlation between nutrients such as folic acid, vitamin B₁₂, vitamin D, iron, selenium, zinc, and n-3 fatty acids and psychological state. The nutrients that claim most attention relating to postpartum depression are n-3 essential fatty acids. Insufficient intake of n-3, folic acid, vitamins B and iron is observed in pregnant women. Failing to meet the needs of the mother due to malnutrition during pregnancy can increase the risk of depleting the body’s nutrient reserves and developing postpartum. This risk factor needs to be kept in check by determining and keeping track of the nutrient needs of the mother during the perinatal period.

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Hennel, Devon B., Justin R. Cohen, and Brian D. Cohen. "Relationship Between Single Nucleotide Polymorphisms and Dysregulation of the HPA axis in Predisposition to Depression." FASEB Journal 34, S1 (April 2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.03464.

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Paulik, Georgie, Johanna C. Badcock, and Murray T. Maybery. "The multifactorial structure of the predisposition to hallucinate and associations with anxiety, depression and stress." Personality and Individual Differences 41, no. 6 (October 2006): 1067–76. http://dx.doi.org/10.1016/j.paid.2006.04.012.

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Richard-Devantoy, Stéphane, Sébastien Guillaume, Emilie Olié, Philippe Courtet, and Fabrice Jollant. "Altered explicit recognition of facial disgust associated with predisposition to suicidal behavior but not depression." Journal of Affective Disorders 150, no. 2 (September 2013): 590–93. http://dx.doi.org/10.1016/j.jad.2013.01.049.

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Albert, Paul R., and Chawki Benkelfat. "The neurobiology of depression—revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies." Philosophical Transactions of the Royal Society B: Biological Sciences 368, no. 1615 (April 5, 2013): 20120535. http://dx.doi.org/10.1098/rstb.2012.0535.

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The serotonin system originates from a small number of neurons (a few hundred thousand of the 100 billion in man) located in the midbrain raphe nuclei, that project widely throughout the central nervous system to influence a large array of inter-related biological functions, not least of which are circuits involved in mood and emotion. The serotonin hypothesis of depression has postulated that a reduction in serotonin leads to increased predisposition to depression. Indeed, it has become evident from therapeutic strategies that affect serotonin activity, that alterations in serotonin may not only predispose to depression, but also to aggressive behaviour, impulsivity, obsessive–compulsive behaviour and suicide. Many potential mechanisms known to alter the genes that regulate the serotonin system, including developmental epigenetic modifications, are presented, as additional evidence implicating the serotonin system. This second issue of two special issues of Philosophical Transactions B presents a series of reviews, perspectives and new findings that argue that the serotonin hypothesis remains an important idea that continues to guide research into the aetiology and treatment of depression.

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Grippo, Angela J., Julia A. Moffitt, and Alan Kim Johnson. "Cardiovascular alterations and autonomic imbalance in an experimental model of depression." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 282, no. 5 (May 1, 2002): R1333—R1341. http://dx.doi.org/10.1152/ajpregu.00614.2001.

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Depressed patients with and without a history of cardiovascular pathology display signs, such as elevated heart rate, decreased heart rate variability, and increased physiological reactivity to environmental stressors, which may indicate a predisposition to cardiovascular disease. The specific physiological mechanisms associating depression with such altered cardiovascular parameters are presently unclear. The current study investigated cardiovascular regulation in the chronic mild stress rodent model of depression and examined the specific autonomic nervous system mechanisms underlying the responses. Sprague-Dawley rats exposed to a series of mild, unpredictable stressors over 4 wk displayed anhedonia (an essential feature of human depression), along with elevated resting heart rate, decreased heart rate variability, and exaggerated pressor and heart rate responses to air jet stress. Results obtained from experiments studying autonomic blockade suggest that cardiovascular alterations in the chronic mild stress model are mediated by elevated sympathetic tone to the heart. The present findings have implications for the study of pathophysiological links between affective disorders and cardiovascular disease.

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Popova, Nina K., Anton S. Tsybko, and Vladimir S. Naumenko. "The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference." International Journal of Molecular Sciences 23, no. 15 (August 8, 2022): 8814. http://dx.doi.org/10.3390/ijms23158814.

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Being different multifactorial forms of psychopathology, aggression, depression and suicidal behavior, which is considered to be violent aggression directed against the self, have principal neurobiological links: preclinical and clinical evidence associates depression, aggression and suicidal behavior with dysregulation in central serotonergic (5-HT) neurotransmission. The implication of different types of 5-HT receptors in the genetic and epigenetic mechanisms of aggression, depression and suicidality has been well recognized. In this review, we consider and compare the orchestra of 5-HT receptors involved in these severe psychopathologies. Specifically, it concentrates on the role of 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3 and 5-HT7 receptors in the mechanisms underlying the predisposition to aggression, depression and suicidal behavior. The review provides converging lines of evidence that: (1) depression-related 5-HT receptors include those receptors with pro-depressive properties (5-HT2A, 5-HT3 and 5-HT7) as well as those providing an antidepressant effect (5-HT1A, 5-HT1B, 5-HT2C subtypes). (2) Aggression-related 5-HT receptors are identical to depression-related 5-HT receptors with the exception of 5-HT7 receptors. Activation of 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C receptors attenuate aggressiveness, whereas agonists of 5-HT3 intensify aggressive behavior.

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Garcez, Michelle L., Ana Carolina B. Falchetti, Francielle Mina, and Josiane Budni. "Alzheimer´s Disease associated with Psychiatric Comorbidities." Anais da Academia Brasileira de Ciências 87, no. 2 suppl (August 25, 2015): 1461–73. http://dx.doi.org/10.1590/0001-3765201520140716.

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Alzheimer's disease (AD) is the most common cause of dementia and has become a severe public health issue. It is estimated that globally, 35.6% of people have some form of dementia. This number is expected to double by 2030, and possibly even triple by 2050. The disease is associated with deficits in cognition/memory and a reduced ability in coping with everyday life. Moreover, patients can experience behavioral alterations such as mood swings, depression and hallucinations. Therefore, it is common to find the presence of neuropsychiatric comorbidities such as depression, schizophrenia and bipolar disorder during the course or development of AD. These disorders can become severe enough to interfere with the patients daily functioning, and can worsen the course of the disease. However, little is known about the causal relationship between psychiatric comorbidities and AD, or the reasons for the predisposition of some individuals to such disorders. Therefore, the purpose of this review is to clarify the causal relationship between depression, schizophrenia and bipolar disorder with AD.

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Johnson, Emma C., Fazil Aliev, Jacquelyn L. Meyers, Jessica E. Salvatore, Rebecca Tillman, Yoonhoo Chang, Anna R. Docherty, et al. "Associations between Suicidal Thoughts and Behaviors and Genetic Liability for Cognitive Performance, Depression, and Risk-Taking in a High-Risk Sample." Complex Psychiatry 7, no. 1-2 (2021): 34–44. http://dx.doi.org/10.1159/000517169.

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Background: Suicidal thoughts and behaviors (STBs) and nonsuicidal self-injury (NSSI) behaviors are moderately heritable and may reflect an underlying predisposition to depression, impulsivity, and cognitive vulnerabilities to varying degrees. Objectives: We aimed to estimate the degrees of association between genetic liability to depression, impulsivity, and cognitive performance and STBs and NSSI in a high-risk sample. Methods: We used data on 7,482 individuals of European ancestry and 3,359 individuals of African ancestry from the Collaborative Study on the Genetics of Alcoholism to examine the links between polygenic scores (PGSs) for depression, impulsivity/risk-taking, and cognitive performance with 3 self-reported indices of STBs (suicidal ideation, persistent suicidal ideation defined as ideation occurring on at least 7 consecutive days, and suicide attempt) and with NSSI. Results: The PGS for depression was significantly associated with all 4 primary self-harm measures, explaining 0.6–2.5% of the variance. The PGS for risk-taking behaviors was also associated with all 4 self-harm behaviors in baseline models, but was no longer associated after controlling for a lifetime measure of DSM-IV alcohol dependence and abuse symptom counts. Polygenic predisposition for cognitive performance was negatively associated with suicide attempts (q = 3.8e−4) but was not significantly associated with suicidal ideation nor NSSI. We did not find any significant associations in the African ancestry subset, likely due to smaller sample sizes. Conclusions: Our results encourage the study of STB as transdiagnostic outcomes that show genetic overlap with a range of risk factors.

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Pujol, Pascal, Nathalie Alegre, Pierre vande Perre, Yves-Jean Bignon, Jean Chiesa, Marie Christine Picot, Virginie Galibert, Helena Bertet, and Carole Corsini. "Psychosocial and clinical factors of probands impacting intrafamilial disclosure and uptake of genetic testing in families with BRCA1/2 or MMR gene mutations." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e13151-e13151. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e13151.

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e13151 Background: Intrafamilial disclosure of hereditary cancer predisposition in BRCA1/2 and mismatch repair gene (MMR) syndromes allows appropriate prevention strategies in at-risk relatives. We previously showed in a nationwide study that the uptake of genetic targeted testing (GTT) in these families by relatives was only 30%. We aimed to identify the medical and psychosocial factors affecting the proband’s intrafamilial disclosure and relatives’ uptake of GTT in BRCA1/2 or MMR syndromes. Methods: We assessed clinical variables, family history and several psychological variables of probands (depression, anxiety, alexithymia, optimism, coping, family relationship, perception of cancer risks and of hereditary transmission risks), together with disclosure and verified uptake of GTT in BRCA1/2 or MMR families. Results: Among relatives eligible for GTT, 68% were informed of the predisposition and 37% underwent GTT, according to proband reports. Intrafamilial disclosure was inversely associated with the degree of kinship (P < 0.01). In multivariable analysis, disclosure increased with time since proband’s genetic diagnosis (P < 0.01) and proband’s feeling of family cohesion (P = 0.01). GTT uptake increased with proband’s depression score (P = 0.02) and decreased with proband’s perception of cancer risks (P = 0.03). BRCA1/2 and MMR groups did not differ in findings concerning family information and GTT uptake. Conclusions: This study identified factors affecting disclosure to relatives and GTT uptake in BRCA1/2 and MMR syndromes and gives new insights to improve probands’ follow-up and intrafamilial sharing of genetic information.

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Jandrić-Kočić, Marijana. "Postpartal depression and thyroid disorders." Praxis medica 49, no. 1-2 (2020): 53–57. http://dx.doi.org/10.5937/pramed2002053j.

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Introduction: Postpartum depression negatively affects a woman's quality of life and the development of a relationship with her child, which can have far-reaching consequences on the cognitive, behavioral and emotional development of the child. Etiology includes genetic predisposition, sudden hormonal changes, and sociodemographic factors. Case report: A 28-year-old patient, married, mother of a one-month-old boy. She graduated from the High school of economics, unemployed. She appears in the family medicine clinic due to chronic fatigue and bad mood, at the insistence of her husband, who thinks that she needs professional help. She grew up in a harmonious family. He gets along well with his wife, there are no existential problems. It denies previous illnesses. Neat appearance, inconspicuous posture and behavior, psychomotor diskette slowed down, more sparse spontaneous verbalization, slightly compromised volitional instinctual dynamisms, lowered basic mood. In the laboratory findings, hypothyroidism with elevated thyroid peroxidase antibody and antithyreoglobulin antibodies is detected. The thyroid ultrasound verifies the right lobe of 46x14x15mm, the left lobe of 48x13x12mm, inhomogeneous and easily hypoechoic structure. The Edinburgh Postnatal Depression Scale indicates the presence of depression (total score 18). The patient is referred for a consultative examination by a psychiatrist and a nuclear medicine specialist. Psychiatrist indicates the introduction of Sertralin 50 mg tablets (1x1/2 for the first seven days, then 1x1) and Bromasepam tablets 1,5 mg (2x1/2), nuclear specialist Levotiroskin sodium tablets 50 mcg (1x1/2 for 5 days and 1x1 for 2 days). After six months, withdrawal of the symptoms of the disease and exclusion of therapy by a psychiatrist. Conclusion: Autoimmune thyroid disease is a significant and often unrecognized cause of postpartum depression. Early detection and timely therapeutic intervention of these have a significant role in the prevention and successful treatment of postpartum depression.

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Oxenkrug, G. "Genetic and Environmental Impacts in Major Depressive Disorder are Mediated Via Kynurenine Pathway of Tryptophan Metabolism." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70899-5.

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We were first to propose up-regulation of KYN pathway of TRY metabolism as an etiological factor in depression: “in depression metabolism of TRY is shunted away from serotonin production, and towards KYN production” since “activity of liver TRY-pyrrolase is stimulated by raised blood corticosteroids levels” (Lapin & Oxenkrug, Lancet, 1969). TRY-pyrrolase, i.e., tryptophan-2,3-dioxygenase (TDO) was the only known enzyme catalyzing TRY conversion into KYN. TDO is mostly located in liver and activated by cortisol and prolactin. Seven years later another enzyme catalyzing TRY conversion into KYN, indoleamine-2,3-dioxygenase (IDO), was discovered. IDO is located in microglia, astrocytes and macrophages, and transcriptionally induced by pro-inflammatory cytokines. Discovery of neurotropic activity of kynurenines suggested that upregulation of TRY - KYN pathway not only augments serotonin deficiency but also underlines depression-associated anxiety, psychosis and cognitive decline. Simultaneous presence of high promoters alleles of pro-inflammatory cytokines genes (IFNG and TNF-alpha) determines genetic predisposition to depression via up-regulation of IDO while impact of environmental stresses is mediated via hormonal activation of TDO. Potentiation of IFNG-induced up-regulation of IDO by stress hormones further underscores the importance TRY-KYN pathway as major meeting point of gene-environment interaction in depression and as a new target for pharmacological intervention.

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Zhu, Jinxiu, Wenjuan Ying, Li Zhang, Gangyi Peng, Weiju Chen, Enoch Odame Anto, Xueqing Wang, et al. "Psychological symptoms in Chinese nurses may be associated with predisposition to chronic disease: a cross-sectional study of suboptimal health status." EPMA Journal 11, no. 4 (October 14, 2020): 551–63. http://dx.doi.org/10.1007/s13167-020-00225-y.

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Abstract Background Suboptimal health status (SHS) is a reversible state between ideal health and illness and it can be effectively reversed by risk prediction, disease prevention, and personalized medicine under the global background of predictive, preventive, and personalized medicine (PPPM) concepts. More and more Chinese nurses have been troubled by psychological symptoms (PS). The correlation between PS and SHS is unclear in nurses. The purpose of current study is to investigate the prevalence of SHS and PS in Chinese nurses and the relationship between SHS and PS along with predisposing factors as well as to discuss the feasibility of improving health status and preventing diseases according to PPPM concepts in Chinese nurses. Methods A cross-sectional study was conducted with the cluster sampling method among 9793 registered nurses in Foshan city, China. SHS was evaluated with the Suboptimal Health Status Questionnaire-25 (SHSQ-25). Meanwhile, the PS of depression and anxiety were evaluated with Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) self-assessment questionnaires. The relationship between PS and SHS in Chinese nurses was subsequently analyzed. Results Among the 9793 participants, 6107 nurses were included in the final analysis. The prevalence of SHS in the participants was 74.21% (4532/6107) while the symptoms of depression and anxiety were 47.62% (2908/6107) and 24.59% (1502/6107) respectively. The prevalence of SHS in the participants with depression and anxiety was significantly higher than those without the symptoms of depression (83.3% vs 16.7%, P < 0.001) and anxiety (94.2% vs 5.8%, P < 0.0001). The ratio of exercise habit was significantly lower than that of non-exercise habit (68.8% vs 78.4%, P < 0.001) in SHS group. Conclusions There is a high prevalence of SHS and PS in Chinese nurses. PS in Chinese nurses are associated with SHS. Physical exercise is a protective factor for SHS and PS so that the exercise should be strongly recommended as a valuable preventive measure well in the agreement with PPPM philosophy. Along with SDS and SAS, SHSQ-25 should also be highly recommended and applied as a novel predictive/preventive tool for the health measures from the perspectives of PPPM in view of susceptible population and individual screening, the predisposition to chronic disease preventing, personalization of intervention, and the ideal health state restoring.

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Vaughn, Angela Taylor, and Gwendolyn L. Hooper. "Development and Implementation of a Postpartum Depression Screening Program in the NICU." Neonatal Network 39, no. 2 (March 1, 2020): 75–82. http://dx.doi.org/10.1891/0730-0832.39.2.75.

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Postpartum depression (PPD) is higher among NICU mothers compared to mothers without infants in the NICU. Routine screening improves early PPD identification and treatment for mothers. Key national women and infant organizations endorse facility-based policies that address PPD screening. In addition to PPD screening, the key national organizations recommend facilities providing care to women and infants develop a method of referral for maternal PPD evaluation, treatment, and follow-up. Due to the timing, onset, and maternal predisposition to PPD, the NICU is a prime setting for PPD screening. Despite recommendations, PPD screening is not routine in the NICU. This article describes the development and assessment of a PPD screening program implemented in the NICU. Data analysis of 30 NICU mothers evaluated the risk of PPD based on screening tool scores, maternal diagnostic evaluation compliance, and documentation of maternal follow-up with designated NICU staff.

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Salgado, Irma Visoso, Jayson Leonel Moncada Mendoza, and Hugo Mendieta Zerón. "Mexican pregnant women show higher depression and anxiety with rising age and in the case of being single." Acta medica Lituanica 26, no. 4 (April 14, 2020): 227–36. http://dx.doi.org/10.6001/actamedica.v26i4.4208.

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Background. Pregnancy is an important predisposition period to develop anxiety and depression, with a direct impact on the woman’s offspring. The aim of this study was to report the correlation between depression and anxiety in pregnant women and its association with the marital status and age. Materials. A descriptive, retrospective and cross-sectional study was conducted in the outpatient care of the Psychology Service at the “Mónica Pretelini Sáenz” Maternal Perinatal Hospital (HMPMPS), Toluca, Mexico, from June 2012 to March 2019. As routine, the Beck Depression Inventory (BDI-II) and the Beck Anxiety Inventory-Trait (BAIT), were applied to all women seeking attention at the HMPMPS. Only pregnant patients were selected for this study, with the women referred for the first time to the external Psychology Clinic as inclusion criteria. Pearson’s correlation coefficient and the frequency of cases for age, BDI-II, and BAIT were obtained using the IBM SPSS Statistics ® v.23 software. Results. The study included 2947 pregnant patients with a mean age of 28.6 ± 6.9 years. Of these, 2616 (88.8%) presented with mild anxiety, 269 (9.1%) with moderate, and 62 (2.1%) with severe anxiety. On the other hand, 2149 (72.9%) patients presented with minimal depression, 341 (11.6%) mild depression, 268 (9.1%) moderate depression, and 189 (6.4%) had severe depression. The correlations between age and BDI-II was –0.026 (P = 0.152), between age and BAI was –0.038 (P = 0.037), and between BAIT and BDI-II 0.650 (P ≤ 0.001). Conclusions. The age group with the highest frequency of depression and anxiety was from 20 to 29 years. The absence of a stable partner represented an important risk factor for anxiety and depression during pregnancy.

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