Готові списки джерел за темами / Precise Selective Path Profiling

Добірка наукової літератури з теми "Precise Selective Path Profiling"

Автор: Grafiati

Опубліковано: 6 вересня 2023

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Статті в журналах з теми "Precise Selective Path Profiling"

Apiwattanapong, Taweesup, and Mary Jean Harrold. "Selective path profiling." ACM SIGSOFT Software Engineering Notes 28, no. 1 (January 17, 2003): 35–42. http://dx.doi.org/10.1145/634636.586104.

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Eaton, Brian, Jeff Stewart, Jon Tedesco, and N. Cihan Tas. "Distributed Latency Profiling through Critical Path Tracing." Communications of the ACM 66, no. 1 (December 20, 2022): 44–51. http://dx.doi.org/10.1145/3570522.

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Wu, Zhichao, Zied Abdullaev, Drew Pratt, Hye-Jung Chung, Shannon Skarshaug, Valerie Zgonc, Candice Perry, et al. "PATH-46. DIAGNOSTIC IMPACT OF THE CNS TUMOR METHYLATION PROFILING IN A NEUROPATHOLOGY CONSULT PRACTICE." Neuro-Oncology 23, Supplement_6 (November 2, 2021): vi125—vi126. http://dx.doi.org/10.1093/neuonc/noab196.498.

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Abstract DNA methylation profiling coupled with the application of CNS tumor methylation classifier has contributed to precise and accurate diagnostics for a range of tumor types involving the central nervous system. The impact and characteristics of methylation profiling on tumor diagnosis has not been fully assessed in the setting of neuropathology consultation practice. A consecutive series of 1,258 surgical neuropathology samples obtained primarily in a consultation practice were profiled over 2-year period and analyzed using the DKFZ/Heidelberg CNS tumor methylation classifier. Among the 1,045 cases received from outside institutions for consultation, the classifier was able to refine a histologically diagnosed entity (e.g. medulloblastoma) in 13.3% (n = 139) cases. A substantially new diagnosis was able to be rendered in an additional 17.9% (n = 187) cases, many of which could be confirmed using orthogonal methods. A “suggestive” (0.30-0.84) classifier score was found in 23% (242) cases and we found that complementary methods (UMAP, t-SNE and nearest-neighbors) were able to resolve this uncertainty in 118 cases. We found tumor purity significantly associated with varied classifier score (p = 1.53e-11). Computational tumor purity adjustment by deconvolution on a subset of gliomas provided a proof-of-concept to resolve diagnostics in the setting of low tumor purity. Overall, this work directly assesses the benefit of methylation classification in a set of diagnostically challenging CNS tumors, addresses tumor purity diminished methylation signal and provides complementary approaches to address diagnostics in cases of low-confidence classifier scores.

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Schepke, Elizabeth, Maja Löfgren, Torsten Pietsch, Thomas Olsson Bontell, Teresia Kling, Anna Wenger, Sandra Ferreyra Vega, et al. "PATH-08. DNA methylation profiling improves routine diagnostics of paediatric CNS tumours: a prospective population-based study." Neuro-Oncology 24, Supplement_1 (June 1, 2022): i159—i160. http://dx.doi.org/10.1093/neuonc/noac079.592.

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Abstract AIMS: Paediatric brain tumours are rare and establishing a precise diagnosis can be challenging. Analysis of DNA methylation profiles has been shown to be a reliable method to classify central nervous system (CNS) tumours with high accuracy. We aimed to prospectively analyse CNS tumours diagnosed in Sweden, to assess the clinical impact of adding DNA methylation-based classification to standard paediatric brain tumour diagnostics in an unselected cohort. Methods: All CNS tumours diagnosed in children (0-18 years) during 2017-2020 were eligible for inclusion provided sufficient tumour material was available. Tumours were analysed using genome-wide DNA methylation profiling and classified by the MNP brain tumour classifier. The initial histopathological diagnosis was compared to the DNA methylation-based classification. For incongruent results, a blinded re-evaluation was performed by an experienced neuropathologist. Results: 240 tumours with a histopathology-based diagnosis were profiled. A high-confidence methylation score of 0.84 or more was reached in 78% of the cases. In 69%, the histopathological diagnosis was confirmed and for some of these also refined, 6% were incongruent and the re-evaluation favoured the methylation-based classification. In the remaining 3% of cases, the methylation class was non-contributory or could not be predicted. The change in diagnosis would have had a direct impact on the clinical management in 5% of all patients.Conclusions: Integrating DNA methylation-based tumour classification into routine clinical analysis improves diagnostics and molecular information important for treatment decisions. The results from methylation profiling should be interpreted in the context of clinical and histopathological information.

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Sahu, A. K., G. K. Sahu, D. K. Dash, S. P. Mishra, K. Mishra, P. Kashyap, and V. Jain. "ASSESSMENT OF IN VITRO NARINGENIN RELEASE FROM SOLID LIPID NANOPARTICLES AND KINETIC MODEL PROFILING: APPLIED ULTRAVIOLET-VISIBLE SPECTROPHOTOMETER." INDIAN DRUGS 54, no. 11 (November 28, 2017): 46–57. http://dx.doi.org/10.53879/id.54.11.11035.

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A new, simple, specific, rapid, precise, highly accurate, reproducible and cost effective Ultraviolet-Visible spectrophotometric method was developed and validated, according to the International Harmonization Guidelines, for the determination of naringenin from solid lipid nanoparticles. Absorption maximum of Naringenin was found to be at 287.49nm in methanol. The linearity range was found to be 5-25μg/mL with high correlation coefficient value of 0.999. The detection and quantification limits were found to be 0.1879μg/mL and 0.5694μg/mL, respectively. This method was shown to be specific, selective, precise at the intra-day (relative standard deviation less than 0.7046%) and inter-day (relative standard deviation less than 1.5424%) level and accurate with recoveries between 98.77-100.43% (relative standard deviation less than 0.3924%). Method robustness observation indicates that method was robust. The suitability of the method for naringenin quantifications was assessed by the determination of entrapment parameters and by studying the naringenin release profile from SLNs. High entrapment efficiency (91.922 ± 0.717%) and drug loading (3.506 ± 0.027%) were observed. Kinetic models (zero order, first order, Higuchi, Hixson-Crowell, Korsmeyer-Peppas and Baker-Lonsdale) were used to fit the obtained release profile and to predict the in vivo performance of naringenin-loaded SLNs. An anomalous non-Fickian transport was found, which indicate a controlled drug release system.

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Brusač, Jeličić, Amidžić Klarić, Nigović, Turk, Klarić, and Mornar. "Pharmacokinetic Profiling and Simultaneous Determination of Thiopurine Immunosuppressants and Folic Acid by Chromatographic Methods." Molecules 24, no. 19 (September 24, 2019): 3469. http://dx.doi.org/10.3390/molecules24193469.

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With the increase in the number of medicines patients have to take, there has been a rapid rise of fixed-dose combinations (FDCs) in the last two decades. Prior to FDC development, pharmacokinetic properties of active pharmaceutical ingredients (APIs) have to be evaluated, as well as methods for their determination developed. So as to increase patient compliance in inflammatory bowel disease, three novel FDCs of thiopurine immunosuppressants and folic acid are proposed; physico-chemical and pharmacokinetic properties such as hydrophobicity, lipophilicity and plasma protein binding of all APIs are evaluated. Moreover, experimental results of different properties are compared to those computed by various on-line prediction platforms so as to evaluate the viability of the in silico approach. A simultaneous method for their determination is developed, optimized, validated and applied to commercial tablet formulations. The method has shown to be fast, selective, accurate and precise, showing potential for reliable determination of API content in proposed FDCs during its development.

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Wuestefeld, Andreas, and Matt Wilks. "How to twist and turn a fiber: Performance modeling for optimal DAS acquisitions." Leading Edge 38, no. 3 (March 2019): 226–31. http://dx.doi.org/10.1190/tle38030226.1.

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The success of a distributed acoustic sensing (DAS) survey depends on strain energy impeding at favorable angles at most sections of the fiber. Although constrained to the path of the wellbore, there are various design parameters that can influence the recorded DAS amplitude. We present here a method to model the performance of DAS installations. We use precise raypath modeling in complex velocity models to determine ray incidence angles and show variations between different wrapping angles and detection thresholds. We then propose a way to evaluate the performance of the DAS acquisition design, and how to optimize processing, based on the percentage of DAS channels above a chosen amplitude threshold. For microseismic studies, the best wrapping angle of the fiber can be determined, which may be defined as covering the target area most homogeneously. For vertical seismic profiling projects, surface shot positions can be evaluated for their predicted recorded energy.

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Barboza, Mariana, David A. Sela, Claire Pirim, Riccardo G. LoCascio, Samara L. Freeman, J. Bruce German, David A. Mills, and Carlito B. Lebrilla. "Glycoprofiling Bifidobacterial Consumption of Galacto-Oligosaccharides by Mass Spectrometry Reveals Strain-Specific, Preferential Consumption of Glycans." Applied and Environmental Microbiology 75, no. 23 (October 2, 2009): 7319–25. http://dx.doi.org/10.1128/aem.00842-09.

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ABSTRACT Galacto-oligosaccharides (GOS) are versatile food ingredients that possess prebiotic properties. However, at present there is a lack of precise analytical methods to demonstrate specific GOS consumption by bifidobacteria. To better understand the role of GOS as prebiotics, purified GOS (pGOS) without disaccharides and monosaccharides was prepared and used in bacterial fermentation experiments. Growth curves showed that all bifidobacteria assayed utilized and grew on pGOS preparations. We used a novel mass spectrometry approach involving matrix-assisted laser desorption ionization-Fourier transform ion cyclotron resonance (MALDI-FTICR) to determine the composition of oligosaccharides in GOS syrup preparations. MALDI-FTICR analysis of spent fermentation media demonstrated that there was preferential consumption of selected pGOS species by different bifidobacteria. The approach described here demonstrates that MALDI-FTICR is a rapid-throughput tool for comprehensive profiling of oligosaccharides in GOS mixtures. In addition, the selective consumption of certain GOS species by different bifidobacteria suggests a means for targeting prebiotics to enrich select bifidobacterial species.

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Liu, Anthony P. Y., Chris T. L. Chan, Edmond S. K. Ma, Wilson W. S. Ho, Dennis T. L. Ku, Matthew M. K. Shing, Amanda N. C. Kan, Godfrey C. F. Chan, and Ho-Keung Ng. "PATH-10. Nanopore sequencing reveals novel ALK fusion with interposed element in a neonate with hemispheric glioma." Neuro-Oncology 24, Supplement_1 (June 1, 2022): i160. http://dx.doi.org/10.1093/neuonc/noac079.594.

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Abstract Here we describe the clinical course and unique molecular findings in a female neonate with infantile hemispheric glioma (IHG). The patient presented at the age of 17 days with macrocephaly and suboptimal weight gain. MRI brain revealed an 8.5cm mass over the right frontal region with significant mass effect and entrapment of ventricles. Urgent ventriculoperitoneal shunt insertion and biopsy of the highly vascular lesion was performed. Pathology was compatible with glioblastoma multiforme. Methylation profiling classified the sample as inflammatory tumor tissue (MNP v11b4), while panel RNA-sequencing revealed a fusion event between HMBOX1 and ALK which has not been described in primary CNS tumors. Long-read sequencing with the Nanopore system further revealed complex genomic rearrangement involving an interposed genomic fragment from a third chromosome with validation by Sanger sequencing. Based on an integrated diagnosis of IHG, the patient went on to receive neoadjuvant chemotherapy per the CNS-14 protocol (cyclophosphamide, carboplatin, etoposide) with significant tumor shrinkage. Near total removal of the lesion was achieved after 4 cycles of chemotherapy and adjuvant treatment with 4 additional cycles was given. The patient tolerated therapy well other than self-limiting transaminitis. At the end of treatment, the patient enjoyed intact neurology and satisfactory developmental progress. Our case report illustrates the value a multi-pronged approach to characterizing rare pediatric CNS tumors. The precise delineation of breakpoints in fusion-driven tumors might be of value in the design of cfDNA-based assays. (APYL and CTLC contributed equally to the submission)

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Marazziti, Donatella, Jorge Perez, and Giovanni B. Cassano. "Is Obsessive-Compulsive Disorder Caused by a Second-Messenger Imbalance?" CNS Spectrums 6, no. 3 (March 2001): 206–9. http://dx.doi.org/10.1017/s1092852900008579.

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AbstractAlthough the precise etiologic nature of obsessive-compulsive disorder (OCD), one of the most common psychiatric conditions, is unknown, several findings indicate involvement of the serotonin (5-HT) transporter. Apart from the specific effects of selective 5-HT reuptake inhibitors, other studies show decreased functionality of the platelet 5-HT transporter in OCD. In this report, the authors combine data from two independent studies of patients with OCD, showing both an increased activity of protein kinase type C (PKC) and a decreased activity of protein kinase type A (PKA). The authors propose a unifying hypothesis that OCD might be determined by an imbalance between PKC and PKA, with a prevalence of the former and, more generally, of the phosphoinositide over the cyclic adenosine monophosphate (cAMP) pathway. Should this hypothesis prove correct, the path would be open for new therapeutic interventions in the treatment of OCD.

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Тези доповідей конференцій з теми "Precise Selective Path Profiling"

Apiwattanapong, Taweesup, and Mary Jean Harrold. "Selective path profiling." In the 2002 ACM SIGPLAN-SIGSOFT workshop. New York, New York, USA: ACM Press, 2002. http://dx.doi.org/10.1145/586094.586104.

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Yang, Chunbai, Imran Ashraf, Xiaoxue Ma, Hao Zhang, and W. K. Chan. "OPE: Transforming Programs with Clean and Precise Separation of Tested Intraprocedural Program Paths with Path Profiling." In 2021 IEEE 21st International Conference on Software Quality, Reliability and Security (QRS). IEEE, 2021. http://dx.doi.org/10.1109/qrs54544.2021.00039.

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