Дисертації з теми "PrAMP"
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Bluhm, Martina E. C., Viktoria A. F. Schneider, Ingo Schäfer, Stefania Piantavigna, Tina Goldbach, Daniel Knappe, Peter Seibel, Lisandra L. Martin, Edwin J. A. Veldhuizen, and Ralf Hoffmann. "N-Terminal Ile-Orn- and Trp-Orn-Motif repeats enhance membrane interaction and increase the antimicrobial activity of Apidaecins against Pseudomonas aeruginosa." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205372.
Повний текст джерелаRavindran, Somasundaram. "Aspects of practical implementations of PRAM algorithms." Thesis, University of Warwick, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386838.
Повний текст джерелаBarcellos, Antonio Marinho Pilla. "PRMP : a scaleable polling-based reliable multicast protocol." Thesis, University of Newcastle Upon Tyne, 1998. http://hdl.handle.net/10443/1981.
Повний текст джерелаLópez, Martínez Andrés. "Parallel Minimum Cuts : An improved CREW PRAM algorithm." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-287962.
Повний текст джерелаDenna avhandling behandlar minsta-snittproblemet i oriktade, viktade grafer. För att hitta det minsta snittet i en graf G med n noder och m kanter presenterar vi en enkel slumpbaserad CREW PRAM algoritm som är baserad på Kargers berömda, slumpbaserade, minsta-snittalgoritm med nära-linjär körtid [STOC’96]. Vår algoritm kräver nära-linjärt arbete O(m log2 n + n log6 n) och lågt djup O(log3 n), och är korrekt med hög sannolikhet. Detta är den första förbättringen till den tidigare bästa CREW PRAM minsta-snittalgoritmen av Geissmann och Gianinazzi [SPAA’18] som kräver O(m log4 n) arbete och har O(log3 n) djup. I sin slumpbaserade och nära-linjära minsta-snittalgoritm använder sig Karger av ett samband mellan minsta snitt och maximala packningar av uppspännande träd vilket förminskar problemet till två delproblem: (i) beräkna en approximativ maximal packning av uppspännande träd S, och (ii) hitta minsta snittet av grafen G som har som mest två kanter i något träd i S—känt som det 2- respekterande minsta-snittproblemet. För att åstadkomma vårt huvudresultat ger vi parallella algoritmer för båda delproblemen. Mer specifikt så presenterar vi följande. En CREW PRAM algoritm för det 2-respekterande minsta-snittproblemet som kräver O (m log n+n log5 n) arbete och vars djup är O(log2 n). Vi erhåller detta från att parallellisera en ny sekventiell algoritm av Mukhopadhay och Nanongkai [STOC’20] vilken i sig förbättrar Kargers ursprungliga resultat. En EREW PRAM algoritm för att beräkna en approximtiv maximal packning av uppspännande träd som kräver O (m log2 n + n log4 n) arbete och vars djup är O (log3 n). Detta förbättrar den tidigare bästa gränsen för minsta arbete med en faktor log n, hävdad av Karger [STOC 96], och som används av Geissmann och Gianinazzi [SPAA 18]. Utöver detta utvecklar vi följande självständiga resultat: En parallell implementation av ett värdemängdsträd i två dimensioner: givet en mängd av n viktade punkter i planet så kan den konstrueras genom O(n log n) arbete och med O(log2 n) djup genom en EREW PRAM algoritm. I CREW PRAM modellen så stödjer den värdemängdsräkning, värdemängdsrapportering, och förfrågor om värdemängdssummationer optimalt med avseende på arbetet och med O(log n) djup. En sekventiell algoritm med O(log2 n + t log n) körtid för att besvara en förfrågan av ett 2-dimensionellt viktat värdemängdsstickprov i ett värdemängdsträd på n viktade punkter. Förfrågan definieras som följande: givet ett heltal t, välj slumpmässigt oberoende t punkter ur en värdetalsmängd. Varje punkt väljs med sannolikhet proportionell till sin vikt. I CREW PRAM modellen visar vi hur man kan stödja förfrågan optimalt med avseende på arbetet och med O(log n) djup.
Gross, Jürgen. "Eine Implementierung von Lubys Algorithmus für die Cray T3E." [S.l.] : Universität Stuttgart , Fakultät Informatik, 1999. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8385928.
Повний текст джерелаWe̜growicz, Paulina. "Linear programming on the reconfigurable mesh and the CREW PRAM." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59985.
Повний текст джерелаVulcani-Freitas, Tânia Maria [UNIFESP]. "Perfil de expressão dos genes MYC, MYCN, TERT, ASPM e PRAME em Meduloblastoma." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9928.
Повний текст джерелаMeduloblastoma (MB) é o tumor maligno de sistema nervoso central (SNC) mais comum em criança, compreendendo 20% dos tumores primários de SNC e 40% dos tumores cerebelares da infância. Devido sua forte tendência metastática, o tratamento padrão pós-operatório inclui radio e quimioterapia, cujo impacto causa distúrbios endócrinos e de crescimento, e disfunção neurocognitiva a longo prazo. Frente a esses efeitos negativos, muitas pesquisas em meduloblastoma têm sido realizadas com intuito de obter conhecimento biológico desses tumores para tentar identificar fatores prognósticos moleculares que possam orientar os tratamentos, tornando-os mais específicos e menos agressivos. Alguns estudos em MB têm sugerido que a expressão do oncogene MYC está associada com diminuição da sobrevida e sua superexpressão com maior agressividade do tumor. Por isso, MYC pode ser um indicador importante de prognóstico, além de modulador do comportamento desta doença. Enquanto o gene MYC é expresso em uma variedade de tecidos, a expressão de MYCN, outro membro da família MYC, é restrita a estágios precoces do desenvolvimento embrionário de alguns tecidos apenas, entre eles, o sistema nervoso central e periférico, sendo um mediador importante dos efeitos de ativação na proliferação de células precursoras cerebelares. Dessa forma, quando a expressão de MYCN está desregulada, ela aumenta a tumorigenicidade dessas células podendo dar origem ao MB. Além disso, o gene MYC também é considerado importante regulador da transcrição TERT, gene que codifica uma subunidade catálica de da telomerase, enzima importante para carcinogênese e imortalização de células neoplásicas. A atividade anormal da telomerase está presente em 90% dos cânceres e o aumento de sua atividade está associado a eventos clínicos desfavoráveis. Outro gene importante é o ASPM (abnormal spindle-like microcephaly associated) que desempenha função fundamental na neurogênese e proliferação celular durante o desenvolvimento cerebral. Esse gene codifica uma proteína de centrossomo e fuso mitótico que permite a divisão celular simétrica em células neuroepiteliais durante o desenvolvimento e aumento do tamanho cerebral. Alterações em ASPM é a causa mais comum de microcefalia primária em humanos e de falha de segregação, induzindo a aneuploidias e instabilidade genética. Além desses genes, outro gene estudado recentemente, como alvo em xv imunoterapia, é o gene PRAME que codifica um antígeno tumoral que está presente em vários tumores, incluindo meduloblastoma. O gene PRAME possui baixa ou ausência de expressão em tecidos normais, por isso é pode ser um forte candidato como alvo em imunoterapia, que é um tratamento menos tóxico. OBJETIVOS: O objetivo desse estudo foi investigar a expressão dos genes MYC, MYCN, TERT, ASPM e PRAME em fragmentos tumorais de meduloblastoma de crianças e tentar correlacionar com os parâmetros clínicos e verificar se há correlação de MYC, MYCN, TERT entre si, uma vez que estão correlacionados. MÉTODOS: Análise de expressão gênica foi realizada através de PCR quantitativa em tempo real, utilizando sistema SYBR Green, em 37 amostras tumorais de crianças, com média de idade de 8 anos. Para comparação de perfil de expressão foi usada duas amostra de cérebro normal. A análise estatística foi realizada nos programas Graph Pad Prism 4 e VassarStats RESULTADOS: Todas nossas amostras superexpressaram o gene MYCN com valor de quantificação relativa (RQ) mediana igual a 31 com p=0.001; assim como, todas nossas amostras também superexpressaram o gene ASPM com mediana igual a 586, p<0.0001. Do total de amostras, 95%, 81% e 84% superexpressaram TERT, MYC e PRAME respectivamente, sendo os valores de RQ (mediana) iguais a 322, p=0.01; 9.2, p<0.0001; 33, p<0.0001. Apesar da elevada expressão dos genes estudados na maioria das amostras estudadas, houve apenas correlação estatística entre a superexpressão de MYCN (p=0.008) e os pacientes que foram a óbito, e de TERT e os pacientes que recidivaram (p=0.0431). Não encontramos outra correlação estatística entre a superexpressão dos genes e as características clínicas dos pacientes. CONCLUSÃO: Os genes MYC, MYCN e TERT estavam superexpressos nas amostras de meduloblastoma analisadas em uma freqüência muito superior ao demonstrado na literatura, o que sugere que esses três genes podem ajudar na identificação de tumores agressivos, uma vez que o pognóstico desses pacientes continua baseado apenas em parâmentros clínicos. A superexpressão de ASPM em todas as amostras estudadas sugere que este gene pode estar envolvido na origem de MB, como parte da neurogênse anormal durante o desenvolvimento embrionário, porém estudoas funcionais devem ser realizados para confirmar essa hipótese. Por fim, o gene PRAME pode ser candidato à marcador de célula tumoral em MB, podendo no futuro ser candidato como alvo em imunoterapias.
To investigate the expression of genes MYC, MYCN and TERT in tumor fragments of pediatric medulloblastoma and correlate gene expression profiles with clinical parameters. Analysis of gene expression was performed by quantitative PCR real time in 37 tumor samples and correlated with clinical and pathological data. All 37 samples overexpressed MYCN gene (p= 0.001), 95% and 84% of the samples overexpressed TERT and MYC, respectively (p<0.0001). Twenty nine (78%) of all samples had concomitant high expression of MYC, MYCN and TERT genes together. Seventeen (59%) were high-risk classification, 10 (34%) were metastatic (M+) stage, two (7%) were anaplastic or largecell/ anaplastic subtype, eight (28%) of patients relapsed, beyond thirteen (45%) suffered partial surgical resection. and fourteen (48%) died. We found correlation between MYC, MYCN and TERT expression (p<0.0001). The identification of a subgroup with concomitant overexpression of the three investigated genes suggests the possibility of using more than one aspect of molecular indicative of unfavorable prognosis that characterizes the group with poor outcome. However, in future this may be enhanced by targeted therapy for the product TERT as proposed in some neoplasms. The identification of molecular events in the medulloblastoma categorization aims to help at-risk groups moving towards individualized medicine.
TEDE
BV UNIFESP: Teses e dissertações
Denis, Frédéric. "Caractérisation fonctionnelle de PRAM-1 : un nouvel adaptateur des cellules myéloïdes." Paris 11, 2005. http://www.theses.fr/2005PA11T057.
Повний текст джерелаArmstrong, Kylie Jan. "Effectiveness of a pram walking intervention for women experiencing postnatal depression." Thesis, Queensland University of Technology, 2004. https://eprints.qut.edu.au/15837/1/Kylie_Armstrong_Thesis.pdf.
Повний текст джерелаArmstrong, Kylie Jan. "Effectiveness of a Pram Walking Intervention for Women Experiencing Postnatal Depression." Queensland University of Technology, 2004. http://eprints.qut.edu.au/15837/.
Повний текст джерелаSnášel, Martin. "Design dětského kočárku." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-227906.
Повний текст джерелаTiskin, Alexandre. "The design and analysis of bulk-synchronous parallel algorithms." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302334.
Повний текст джерелаLööw, Andreas. "A Functional-Level Simulator for the Configurable (Many-Core) PRAM-Like REPLICA Architecture." Thesis, Linköpings universitet, Programvara och system, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-79049.
Повний текст джерелаHansson, Erik. "Code Generation and Global Optimization Techniques for a Reconfigurable PRAM-NUMA Multicore Architecture." Licentiate thesis, Linköpings universitet, Programvara och system, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111333.
Повний текст джерелаWedin, Erik, and Fredrik Lundeberg. "Prototyping and Modeling of a Temperature Controlled Sleeping Surface in a Child Pram." Thesis, KTH, Skolan för industriell teknik och management (ITM), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-262492.
Повний текст джерелаNoggrann temperaturreglering har stor betydelse för olika applikationer och produkter. Detta gäller till exempel för en eluppvärmd barnvagn, eftersom barn är känsliga mot både kalla- och varma temperaturer. Det är därför viktigt att en temperaturreglerad barnvagn kan hålla en stabil yttemperatur. Syftet med det här arbetet är att utveckla en prototyp och en termodynamisk modell av en elektriskt uppvärmd barnvagn. Med hjälp av modellen ska temperaturregulatorer designas. Forskningen i arbetet gör gällande att utvärdera modell-baserad temperaturreglering av ett sådant system. En "white-box model"-ansats är vald och modellen utvecklas i MATLAB Simulink/Simscape. Modellens noggrannhet förbättras genom att använda uppmätta data i Simulink Design Optimization toolbox för att estimera utvalda parametrar. Den slutliga modellen är därför en "grey-box model". Modellen används sedan för att utveckla temperaturreglering för systemet. Regulatorn implementeras på prototypen och utvärderas mot den simulerade regulatorn samt de ursprungliga kraven på systemet. Den utvecklade regulatorn visar hög ekvivalens mellan simulerade- och uppmätta tester på prototypen. Regulatorn motsvarar de härledda reglerkraven. Resultatet visar att modell-baserad design är en rimlig metod för att utveckla temperaturreglering åt en eluppvärmd barnvagn. Arbetet visar även på hur man kan förbättra noggrannheten på modellen genom att tillämpa uppmätta data från prototyptester.
Alnervik, Erik. "Evaluation of the Configurable Architecture REPLICA with Emulated Shared Memory." Thesis, Linköpings universitet, Programvara och system, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104313.
Повний текст джерелаREPLICA är en grupp av konfigurerbara multiprocessorer som med hjälp utav ett emulerat delat minne realiserar PRAM modellen. Syftet med denna avhandling är att genom benchmarking av olika beräkningsproblem på REPLICA, liknande (SB-PRAM och XMT) och mindre lika (Xeon X5660 och Tesla M2050) parallella arkitekturer, utvärdera hur REPLICA står sig mot andra befintliga arkitekturer. Både prestandamässigt och hur enkel arkitekturen är att programmera effektiv, men även försöka ta reda på om REPLICA är speciellt lämpad för några särskilda typer av beräkningsproblem. Genom att använda välkända Berkeley dwarfs applikationer och opartisk indata från bland annat The University of Florida Sparse Matrix Collection och Rodinia benchmark suite, säkerställer vi att det är relevanta beräkningsproblem som utförs och mäts. Vi visar att dagens parallella arkitekturer har problem med prestandan för applikationer med oregelbundna minnesaccessmönster, vilken REPLICA arkitekturen kan vara en lösning på. Till exempel, så behöver REPLICA endast vara klockad med några få MHz för att matcha både Xeon X5660 och Tesla M2050 för algoritmen breadth first search, vilken lider av just oregelbunden minnesåtkomst. Genom att jämföra effektiviteten för REPLICA gentemot en CPU (Xeon X5660), visar vi att det är lättare att programmera REPLICA effektivt än dagens multiprocessorer.
Stemann, Volker. "Contention resolution in hashing based shared memory simulations /." Paderborn : Heinz Nixdorf Institut, Univ.-GH Paderborn, 1995. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=006901439&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Повний текст джерелаAlbers, Sinje Verfasser], and Carsten [Akademischer Betreuer] [Bokemeyer. "Erfassung von PRAME - und SOX - 2 - spezifischen Antikörpern bei Patienten mit Multiplem Myelom / Sinje Albers. Betreuer: Carsten Bokemeyer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1082347574/34.
Повний текст джерелаZhou, Cheng. "A source-to-source compiler for the PRAM language Fork to the REPLICA many-core architecture." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-80835.
Повний текст джерелаÅkesson, Daniel. "An LLVM Back-end for REPLICA : Code Generation for a Multi-core VLIWProcessor with Chaining." Thesis, Linköpings universitet, PELAB - Laboratoriet för programmeringsomgivningar, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77405.
Повний текст джерелаREPLICA är en VLIW liknande PRAM-NUMA arkitektur, med möjlighet för attkedja ihop instruktioner så att resultat från tidigare instruktioner kan användassom indata till nästa instruktion i samma exekveringssteg. Inom REPLICA projetet finns planer på att utecklar ett nytt C-baserat pro-grammeringsspråk, kompilatorer och bibliotek för att snabbba upp utvecklingen avparallella program. Som en del av REPLICA projektet har vi utvecklat ett kompi-lator back-end för LLVM som kan användas för att generera kod till REPLICA. Vihar även utvecklat en enklare optimerings algoritm för att bättre utnyttja REPLI-CAs förmåga för instruktions parallelisering. Vi har även gjort ändringar i Clang,LLVMs front-end för C/C++/Objective-C, så att vi kan använda inline assembleri REPLICA program. Med Clang kan man kompilera C-kod till LLVMs interna representation somi sin tur genom LLVM och REPLICA back-end kan omvandlas till MBTAC3 as-sembler.
Sharapova, Saida R. "The Role of Stress in Racial Disparities of Preterm and Low Birth Weight Births in Georgia." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/iph_theses/247.
Повний текст джерелаCarvalho, Daniel Diniz de. "Regulação da expressão de SH3BGRL2, D53, PRAME, DAP12 e calcineurina A beta por BCR-ABL e consequências biológicas dessa regulação na LMC." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-03022010-091640/.
Повний текст джерелаTRAIL was shown to selectively kill tumor cells. Not surprisingly, TRAIL is down-regulated in a variety of tumor cells, but the mechanism responsible for TRAIL inhibition remains elusive. Because TRAIL can be regulate by retinoic acid; PRAME was shown to inhibit transcription of retinoic acid receptor target genes through the polycomb protein EZH2; and we have found that TRAIL is inversely correlated with BCR-ABL in CML patients, we decided to investigate the association of PRAME, EZH2 and TRAIL in BCR-ABL-positive leukemia. Here, we demonstrate that PRAME, but not EZH2, is up-regulated in BCR-ABL cells and is associated with the progression of disease in CML patients. In addition, PRAME expression is positively correlated with BCR-ABL and negatively with TRAIL in these patients. Importantly, knocking down of PRAME or EZH2 by RNA interference restores TRAIL expression. Our data reveal a novel regulatory mechanism responsible for lowering TRAIL expression and provide the basis of alternative targets for combined therapeutic strategies for CML.
Wadelin, Frances Roswyn. "The proto-oncoprotein PRAME associates with the Cullin-2E3 ubiquitin ligase complex and is upregulated in response to bacterial pathogen associated molecual patterns." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574661.
Повний текст джерелаWilliams, Thomas Mervyn. "Monitoring the Impact of Scott Base in Antarctica: A Recent Evaluation of Wastewater, Water and Soil Quality at Pram Point, Ross Island." Thesis, University of Canterbury. Gateway Antarctica, Chemistry and Waterways Centre for Freshwater Management, 2012. http://hdl.handle.net/10092/9333.
Повний текст джерелаHorváth, Benjámin [Verfasser], Michel [Gutachter] Noutsias, Torsten [Gutachter] Doenst, and Matthias [Gutachter] Pauschinger. "Systematische Analyse von Publikationen über die T-PreAmp-Präamplifikationsmethode für Genexpressionsanalysen mittels real-time RT-PCR / Benjámin Horváth ; Gutachter: Michel Noutsias, Torsten Doenst, Matthias Pauschinger." Jena : Friedrich-Schiller-Universität Jena, 2018. http://d-nb.info/1170396704/34.
Повний текст джерелаLutz, Mathias [Verfasser], and Stephan [Gutachter] Mielke. "T-Zell-Immunität gegen die tumorassoziierten Antigene HER2/neu, MUC1, PRAME und WT1 bei gesunden Blutspendern und Schwangeren als ein immuntherapeutisches Modell für die allogene Blutstammzelltransplantation / Mathias Lutz ; Gutachter: Stephan Mielke." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1151128694/34.
Повний текст джерелаMartin, Bruno. "Simulations d'automates cellulaires." Habilitation à diriger des recherches, Université de Nice Sophia-Antipolis, 2005. http://tel.archives-ouvertes.fr/tel-00212057.
Повний текст джерелаBergogne, Laurent. "Quelques algorithmes parallèles sur des "séquences de" pour différents modèles de calcul parallèle." Amiens, 1999. http://www.theses.fr/1999AMIE0130.
Повний текст джерелаBuie, Mary Elizabeth. "An Examination of the Impact of Preconception Health on Adverse Pregnancy Outcomes through the Theoretical Lens of Reciprocal Determinism." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3021.
Повний текст джерелаCha, Susan. "The Association between Prenatal Care Content and Quality with Preterm Birth and Maternal Postpartum Health Behaviors." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2079.
Повний текст джерелаBauer-Schaub, Kimberly J. "Effects of Pregnancy-Related Depression on Low Birth Weight Infants." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7597.
Повний текст джерелаLiang, Weifa, and wliang@cs anu edu au. "Designing Efficient Parallel Algorithms for Graph Problems." The Australian National University. Department of Computer Science, 1997. http://thesis.anu.edu.au./public/adt-ANU20010829.114536.
Повний текст джерелаVigouroux, Mathieu Pierre. "Mesure de déformation et cristallinité à l'échelle nanométrique par diffraction électronique en mode précession." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAY012/document.
Повний текст джерелаPrecession electron diffraction (PED) is a recent technique used to minimize acquired diffractionpatterns dynamic effects. The primary intention of this PhD work is to improve PED (PrecessionElectron Diffraction) data analysis and treatment methodologies in order to measure the strain at thenanoscale. The strain measurement is intended to reach a 10-3 strain precision as well as usualmicroscopy techniques like high-resolution imaging. To this end, measurements were made with aJEOL 2010A with a Digistar Nanomegas precession module.The approach developed has been used and tested by measuring the strain in a Si/SiGe multilayeredreference sample with a known Ge Content. Strain measurements reached 1x10-4 sensitivity withexcellent finite element strain simulation agreement. This process has been also applied to measure thestrain in microelectronic InGaAs Quantum Well and an "Ω-gate" experimental transistor devices.The second approach developed has been made to provide a robust means of studying electrontransparent nanomaterial polycrystallinity with precession. Examples of applications of this analysismethod are shown on different devices
Ziadi, Djelloul. "Algorithmique parallèle et séquentielle des automates." Rouen, 1996. http://www.theses.fr/1996ROUES003.
Повний текст джерелаPetrgál, Filip. "Digitálně řízený audio zesilovač ve třídě D s dálkovým ovládáním." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220355.
Повний текст джерелаMukherjee, Soumyadeep. "Antenatal Stressful Life Events and Postpartum Depression in the United States: the Role of Women’s Socioeconomic Status at the State Level." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2631.
Повний текст джерелаDavid, Vincent. "Algorithmique parallèle sur les arbres de décision et raisonnement en temps contraint : étude et application au minimax." Toulouse, ENSAE, 1993. http://www.theses.fr/1993ESAE0008.
Повний текст джерелаPai, Carina Cargnelutti Dal. "Participação popular na prevenção e enfrentamento de desastres ambientais : um estudo de caso em Araranguá/SC." Universidade do Estado de Santa Catarina, 2012. http://tede.udesc.br/handle/handle/1383.
Повний текст джерелаCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
This research constitutes part of a project funded by FAPESC, which objective to promote competence of action in preventing and tackling environmental disaster in the Vale do Itajaí, in the municipality of Ilhota and in the south shore of Santa Catarina, municipality of Araranguá. The main purpose of this research is to promote community participation in disaster risk management in communities Barranca and Baixadinha/Vila São José in Araranguá. The specific objectives proposed are identify and characterize the risk perceptions of communities to stand the occurrence of floods and very strong winds; promote the identification of ways of organizing communities to address and prevent environmental disasters, specifically floods; testing methodologies of Geographic Information System - Participatory (GIS-P) in the mapping of risk and the preventive management of environmental disasters; encourage in promoting dialogue between Civil Defence and communities to articulate for the construction of their Plans Risk Management Participatory (PRMP) providing contributions to the constitution of Community Nuclei Civil Protection and Defense (NUPDECs). The theoretical and thematic framing comprises History Socio-Spatial, Perception Socio-Environmental, the GIS-P, Prevention and Coping With Environmental Disaster and Popular Participation in Disaster Prevention and Coping. The research methodology is qualitative and belong as a case study developed with the two communities, starting from the application of interviews, meetings, workshops, development of social mapping, use of participant observation to build data to integrate a GIS P. The achieved results comprises the historic and environmental characterization, survey of existing data about floods occurred historically, personal understandings about environmental disasters and risks inherent, as well as suggestions of structural and non-structural measures for inclusion in PRMP, making possible communities involve in a reflection of how their perceptions and experiences can contribute to the prevention of environmental disasters and coping, while minimizing their environmental impacts as well as making them more resilient. Adding to the results is the discussion with the participation of communities and Civil Defense, about actions for the constitution of NUPDECs in consonance with the actions of the local Civil Defense, bringing together wills for implementing measures that make possible to increase its resilience by reducing local vulnerability in coping with environmental disasters.
Esta pesquisa constitui-se parte de um projeto financiado pela FAPESC, que visa promover competências de ação na prevenção e enfrentamento de desastres ambientais na região do Vale do Itajaí, no município de Ilhota e no litoral Sul catarinense, município de Araranguá. A finalidade principal desta pesquisa é promover a participação comunitária na gestão de risco de desastres nas comunidades Barranca e Baixadinha/Vila São José, em Araranguá. Como objetivos específicos propôs-se identificar e caracterizar as percepções de risco das comunidades frente à ocorrência de enchentes e ventos fortes; identificar formas de organização das comunidades no sentido de enfrentar e prevenir desastres ambientais, especificamente as enchentes; testar metodologias de Sistema de Informação Geográfica Participativo (SIG-P) no mapeamento de risco e no planejamento preventivo de desastres ambientais; auxiliar na promoção do diálogo entre a Defesa Civil e as comunidades no sentido de se articularem para a construção de seus Planos de Gestão de Risco Participativo (PGRs) fornecendo contributos para a constituição de Núcleos Comunitários de Proteção e Defesa Civil (NUPDECs). O enquadramento teórico-temático compreende a História Ambiental, a Formação Sócio-Espacial, a Percepção Sócio-Ambiental, o SIG-P, a Prevenção e Enfrentamento de Desastres Ambientais e a Participação Popular na Prevenção e Enfrentamento de Desastres. A metodologia da pesquisa é qualitativa enquadrando-se como estudo de caso desenvolvido com as duas comunidades, partindo desde a aplicação de entrevistas, realização de reuniões, desenvolvimento de oficinas de cartografia social, emprego da observação participante até construção de dados para integrar um SIG-P. Os resultados alcançados compreendem a caracterização histórica e ambiental, levantamento de dados existentes sobre as enchentes ocorridas historicamente, entendimentos pessoais sobre desastres ambientais e riscos inerentes, bem como sugestão de medidas estruturais e não estruturais para inclusão nos PGRs, possibilitando envolver as comunidades numa reflexão de como suas percepções e experiências podem contribuir para a prevenção e enfrentamento de desastres ambientais, minimizando seus impactos socioambientais gerados bem como tornando-as mais resilientes. Somando-se aos resultados está a discussão com a participação das comunidades e da Defesa Civil sobre as ações para a constituição dos NUPDECs, em consonância com as ações da Defesa Civil local, reunindo vontades para a concretização de medidas que possibilitem aumentar sua resiliência reduzindo a vulnerabilidade local no enfrentamento de desastres ambientais.
Shih, Chung-Hao, and 施崇豪. "Renaming Problem On PRAM." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/48044355258494987797.
Повний текст джерелаORLANDO, DOMENICO. "Adoptive immunotherapy using PRAME-specific T cells in medulloblastoma." Doctoral thesis, 2019. http://hdl.handle.net/11573/1210408.
Повний текст джерелаSchenk, Tino [Verfasser]. "Untersuchungen zur Regulation des humanen Tumormarkergens PRAME / von Tino Schenk." 2008. http://d-nb.info/987798294/34.
Повний текст джерелаKeller, Jörg [Verfasser]. "Zur Realisierbarkeit des PRAM-Modelles / vorgelegt von Jörg Keller." 2004. http://d-nb.info/972340440/34.
Повний текст джерелаKuan, Yuan-Hung, and 管元弘. "Double Circular Caching Scheme for DRAM/PRAM Hybrid Cache." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/z68n7x.
Повний текст джерела國立臺灣科技大學
資訊工程系
100
DRAM is widely adopted as a cache for secondary storage due to its small access latency. Compared with DRAM, PRAM draws a lot of attention recently, since it provides higher density and has no need to refresh the capacitor charge periodically. The non-volatile nature of PRAM can even reduce compulsory miss, which cannot be avoided by DRAM cache. However, PRAM cache cannot replace DRAM cache due to its endurance issue. Thus DRAM/PRAM hybrid cache becomes a good alternative for traditional DRAM cache. Least recently used (LRU) replacement algorithm and CLOCK-Pro algorithm work well for traditional DRAM cache. But these algorithms shall not be directly applied to DRAM/PRAM hybrid cache since the characteristics of PRAM are not considered. This paper proposed a double circular caching scheme (DCCS) to manage DRAM/PRAM hybrid cache. In our scheme, cached data migrate between DRAM cache and PRAM cache adaptively to achieve good hit ratio while frequent writes to PRAM cache are avoided for endurance concern. The experimental results showed that our scheme can reduce up to 87.10% PRAM write accesses for read-intensive access pattern and up to 44.90% energy consumption for write-intensive access pattern, compared with other caching schemes.
Chen, Chang-Yu, and 陳昶宇. "The Impact of Audit Quality on Earnings Quality- Before and After Promp Scandal." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/90195948364631105568.
Повний текст джерела國立臺北大學
會計學系
97
What the financial statements present are the financial position and the results of operations of an enterprise; nevertheless, if the earnings reporting do not present fairly, the earnings quality and the reliability of the financial statements would be affected. Several researches showed that the audited financial statements could improve the quality of the financial statements and enhance the credibility of information. However, economic incentives might interfere with the audit of CPA and influence the independence of CPA and the audit quality. This study explores the impact of audit quality on earnings quality before and after Promp Scandal. The empirical results show that the audit quality does not have a positive and significant influence on the earnings quality, but it has positive effect after Promp Scandal when CPA firms encounter with lawsuit and the relevant strict regulations. That is, after 2004 the better the audit quality is and the higher the earnings quality is.
Loi, Lai-Keng, та 雷麗琼. "The regulation of PRAME by EGFR may enhance the suppression of RAR-β transactivation". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/16025554028306678463.
Повний текст джерела國立陽明大學
口腔生物研究所
103
According to Statistics of the Ministry of Health and Welfare show that since 1991, oral cancer has become one of top ten cancers in Taiwan, and the yearly cases of cancer death of this disease are rising. Therefore, it become an important issue of public health and epidemiology in recent years. Recently, abundant evidence shows that epidermal growth factor receptor (EGFR) plays a significant role in carcinogenesis in head and neck cancer. When binding with its ligands, such as EGF or TGF-a, it will induce autophosphorylation of EGFR itself and activate downstream signal transducers which will then induce anti-apoptosis and angiogenesis, etc. to promote the tumor progression. Furthermore, preferentially expressed antigen of melanoma (PRAME) is a membrane and cytoplasmic protein expressed higher in malignant than normal cell. Its expression has been reported to be significantly associated with poor outcome of cancers. However, the studies of the association between PRAME and HNSCC or OSCC progression were newly reported in the literatures. However as the corepressor of downstream target of PRAME, RAR-β plays a very important role in carcinogenesis of OSCC, in this study we set to explore the regulation of PRAME by EGFR and its influence of RAR-β transactivation .The main objective of this study includes (1)To explore the change of expression or subcellular localization of PRAME induced by EGFR stimulation.(2) To investigate the molecular mechanisms of PRAME regulated by EGFR.(3)To study the regulation on RARβ activation and malignant phenotype of OSCC by PRAME phosphorylation . In series of experiments, oral cancer cells were treated with 50 ng/ml epidermal growth factor (EGFR), we found the expression level of PRAME can be stimulated by EGFR. In addition, nuclear localization of PRAME can also be induced by EGFR stimulation as well. A phosphorylation event on PRAME by EGFR or its downstream kinase (tyrosine kinase) was suggested to mediate the process by immunoprecipitation assay. We predicted the phosphorylation sites of PRAME by software, which 3 putative phosphorylation sites on PRAME were suggested. We will verify the exact phosphorylation sites and investigate its influence on RARβ transactivation activity and the resulting malignant phenotype of OSCC by this PRAME phosphorylation.
HUANG, YUN-RU, and 黃韻如. "The Impact of Audit Quality on Informativeness of Earnings- Before and After Promp Informativeness Scandal." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/59180852715725563275.
Повний текст джерела國立臺北大學
會計學系
96
Audit quality is on of the key consideration factors whether investors would rely on financial statements to understand the economic reality of the firms. Higher quality auditors are more likely to deter and detect questionable accounting practices and also report those material errors and irregularities. Financial statements audited by higher quality auditors are more credible by investors. The purpose of this study is to examine the impact of audit quality on informativeness of earnings by way of testing the relationship between earning and stock price. We use audit firms’ size as a surrogate for audit quality. The results indicate that informativeness of earnings of Big 4 clients are much higher than those of non-Big 4 clients. These findings implied that audit quality has positive effect on informativeness of earnings. We also find that the impact of audit quality on earnings informativness is different before and after Promp Scandal (year 2004). That is, the impacts of audit quality are stronger after 2004.
Taei-Tehrani, Mohammad Reza. "Pseudo Random Arterial Modulation (PRAM): A Novel ASL Approach to Measure Flow and Blood Transit Times." Thesis, 2012. https://doi.org/10.7916/D88S4WWC.
Повний текст джерелаChurch, Jeremy. "The Water is Thin." 2007. https://scholarworks.umass.edu/theses/10.
Повний текст джерелаHoffmann, Julia [Verfasser]. "Evaluation der Leukämie-Reaktivität von PRAME- und p53-spezifischen T-Zellen bei lymphohämatopoetischen Neoplasien im Rahmen einer adoptiven Immuntherapie / Julia Hoffmann." 2008. http://d-nb.info/995569606/34.
Повний текст джерелаHuang, Ting-Yung, and 黃婷沅. "The prevalence of SNPs and gene expression in MAGE-A3 and PRAME of Taiwan NSCLC patients with or without EGFR mutation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/93691447776832568011.
Повний текст джерела國立臺灣大學
病理學研究所
100
Lung cancer is the leading cause of cancer related death worldwide, and can be divided into non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Typically doctors will consider removing the cancer cell mass and combine this operation with chemo- or radio- therapy, but there may have many side effects of cancer patients. For this reason, developing a new strategy for lung cancer treatment has become an important topic for cancer research. One of them is to develop the method of immunotherapy. Scientists attempt to allow a patients’ immune system to have the ability to recognize the specific antigen of cancer cells and further to kill them. MAGE-A3 and PRAME are two tumor-associated antigens, both of them specifically expressed in cancer cells but not normal cells. According to the interim preliminary data of MAGRIT phase III trial, scientists at GlaxoSmithKline found that patients can have a better clinical outcome when they receive MAGE-A3 antigen specific immunotherapy (ASCI) after their operations; in addition, they also found that the expression levels of these two genes are significantly different between squamous cell carcinoma and adenocarcinoma, and also slightly different with regards to ethnicities. The expression level in Europeans is higher than in Asians. For these reasons, these two genes have become good candidates for studies related to cancer immunotherapy. Considering the low expression rate of MAGE-A3 and PRAME genes and highly mutation frequency of EGFR status in NSCLC patients in Asia especially Southeast Asia, it would be quite interesting to investigate whether the expression levels of MAGE-A3 are related to the status of EGFR. Recently, evidence has also indicated that several single nucleotide polymorphisms (SNPs) exist in both MAGE-A3 and PRAME genes; furthermore, differences with regards to MAGE-A3 or PRAME polymorphism between racial populations may potentially contribute to its regulation as well as the relevant differential mRNA expression and the relationship between the SNPs and the EGFR activation mutation status have become a very important study topics related to cancer immunotherapy in Asia. In this study, we will analyze expression levels by Real-time Quantitative RT-PCR and potential polymorphisms of MAGE-A3 by direct sequencing and PRAME by DNA Mass in NSCLC patients in Taiwan; In addition, we will also investigate whether their expressions are correlated with the EGFR status of these patients.