Дисертації з теми "POT dopé"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-24 дисертацій для дослідження на тему "POT dopé".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Cai, Zhiwei. "Nouveaux matériaux à base de polyoxotitanates (POTs) dopé ou à base de complexe salicylate de titane (IV) et d'argent (I)." Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAF062.
In recent years, titanium dioxide has attracted much attention as a highly stable material with a wide range of applications from white pigment to its applications as a semiconductor or advanced photonic devices. Using recently developed synthetic approaches, the synthesis of atomically well-defined polyoxotitanate (POT, [TixOy(OR)z]) cage molecules can be determined. POTs may be preferred as soluble models of TiO2. Cages doped with a metal M (M-POT) presenting new properties can also be prepared.Two new cages doped with cerium were synthesized by a solvothermal reaction. The cages [Ti28O38(OEt)38CeCl](EtOH)1.4 and [Ti8O7(OEt)21Ce](EtOH) having different solubilities, they will be able to be separated and characterized by 1H NMR and X-ray diffraction. The Fe-doped POTs: [Ti4(OEt)15O(FeCl)] and [FeTi14(OEt)28O14(OH)2] were also synthesized. Then after hydrolysis with or without calcination, materials based on Ce or Fe and TiO2 can be obtained. Emulsions of its materials and with the cerium-doped PVDC polymer were then deposited on a PVC surface. UV absorption and water barrier performance gradually increases with increasing amount of deposited materials. The results are interesting for the use of these materials on the packaging surface of drug tablets, which will increase their expiry date. The Eu-POT cage doped with the Eu(III): Ti2O(OEt)8EuIIICl(EtOH)]2 was also synthesized, then after hydrolysis and calcination, the photoluminescence properties of the obtained material were studied.Finally, an AgITiIV(SC)2(HSC)(CH3CN) complex (SC2- = salicylate) was prepared. After hydrolysis and calcination, the anti-microbial properties of the materials were successfully tested against S. aureus or E. Colis
Stanley, Keith R. "Word and image : Doré/Poe : an enquiry into the role of word and image in the late Romantic period, with specific interest in the participation of Gustave Doré, Edgar Allan Poe and the influence of the gothic revival." Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/22446.
This study is an investigation into the relationship between word and image, with specific interest into the work of Edgar Allan Poe and Gustave Doré. The twenty six illustrations that Doré executed for Poe's The Raven form the basis of the study. The intention is, through analysis of the illustration, to identify the interplay between word and image and also investigate the influence of late Romantic Gothicism. Part One examines the position and roles of verbal/visual enquiry through illustration and text. A survey of theoretical concepts defining illustration is made. A brief examination of nineteenth century perspectives of illustration, including a survey of technical theories follows. The modern theory of semiotics and its bearing on visual investigation is examined. A model for applying these theories is detailed. Part Two is an in-depth examination of all twenty six of Doré's illustrations of The Raven. An introduction to the illustrations precedes the analysis. Each illustration is detailed individually, with information on the engraver, content and poetical position being given at the start. Numbered inserts are employed to relay detailed information on more general topics relates to the poem and illustrations. Part Three is the conclusion to the work. A brief examination of Doré's involvement with the Gothic is made. Notes on Doré's illustrations for The Raven and their reception and a survey of other illustrators of The Raven, particularly Eduard Manet follows. The comparison between Manet's and Doré's illustrations is investigated. The concluding remarks note how the relationship of word and image between Doré and Poe uncovers new information about both the poem and the illustrations. The importance of Romanticism and the Gothic is also noted. The conclusion states how new light on Doré's work makes these twenty six rarely considered illustrations more noteworthy. The study ends with a series of appendices, the text of The Raven by Poe, the twenty six illustrations by Doré and a bibliography.
Khan, Naheed Lubna. "Familial parkinsonism (Parkinson's disease and early onset parkinsonism) : a genetic, clinical study and 18F-dopa PET study." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444816/.
Zazou, Hicham. "Dégradation de pesticides dans l’eau par les procédés d’oxydation avancée (POA)." Thesis, Paris Est, 2015. http://www.theses.fr/2015PEST1071/document.
The intensive use of pesticides in agriculture generates, nowadays, an unprecedented contamination of surface water and groundwater. Conventional treatments applied to waste water containing organic pollutants are based on biological treatments méthods or physical mass transfer methods (decantation, filtration, adsorption of the pollutants on activated carbon), chemical oxidation with ozone, chlorine, etc. However, these methods remain ineffective for the treatment of water polluted by persistent organic pollutants (POPs). Advanced oxidation processes are implemented to degrade and mineralize these pollutants. This PhD thesis work aims to establish an experimental protocol to degrade and mineralize pesticides, chemicals widely used in agriculture in Morocco, such as monochlorobenzene, 1,2-dichlorobenzene, 2,4,5-trichlorophenoxy-acetic acid , and imazalil using the electro-Fenton and anodic oxidation processes with DD Pt or DSA anodes. Thus, the rate of mineralization was 92%, 95%, 92% and 97% for the monochloro-benzene, the 1,2-dichlorobenzene, the 2,4,5-trichlorophenoxyacetic acid , and the imazalil, respectively, after 4 h treatment by electro-Fenton process. These results confirm the effectiveness of electrochemical advanced oxidation processes for treating water polluted by pesticides
Morley, Victoria Lee. "Modelling the G51D alpha-synuclein Parkinson’s mutation in the rat." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28987.
Morrish, Paul K. "A clinical and [18F]dopa PET study of the progression of Parkinson's disease and its treatment by embryonic implantation." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361927.
Milliasseau, Damien. "Synthèse et évaluation physico-chimique de tensioactifs biodégradables et éco-compatibles à partir de pectines pour l’industrie routière." Rennes, Ecole nationale supérieure de chimie, 2016. http://www.theses.fr/2016ENCR0034.
Heider, Saineb [Verfasser]. "Der Zusammenhang zwischen dopaminerger Neurotransmission im Striatum und der Arbeitsgedächtnisleistung sowie anderen kognitiven Funktionen : eine [18F]DOPA-PET-Studie / Saineb Heider." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1234982749/34.
Nioche, Christophe. "Caractérisation des tumeurs gliales en TEP/TDM à la 18F-Dopa et en IRM de perfusion." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112100.
MRI provides morphological information about tumour, but also provides information regarding the micro-vascularization of the tumour. In PET/CT, the accumulation of 18F-FDopa in tumour cells results from the metabolic activity greater than that of healthy tissues. We studied 28 gliomas for which we analysed data from MRI and PET/CT. A registration method has been developed to combine information from both PET and MRI and to extract volumes of interest consistent with the information included in the two modalities. In these volumes, the tumour compartment and normal tissue compartment were identified using a Gaussian mixture model. Parameters from PET or MRI data were then calculated in these compartments. ROC analyses combined with linear discriminant analyses were used to assess whether joint observation of standardized uptake value (SUVmax ) and relative Cerebral Blood Volume (rCBV) or of relative rk1 and rCBV could distinguish between low grade and high grade tumours. We found that using this joint analysis, 82.4% of high-grade tumors and 70.0% of low-grade tumors were correctly classified (AUC of 0.88 for [SUVmax , rCBV] and of 0.92 for [rk1 , rCBV]). Considering the [SUVmax , rCBV] combined information, the sensitivity for detecting high-grade tumors was 95% with a specificity of 60%. The negative predictive value was 52% for a positive predictive value of 95%. Similarly, considering the [rk1 , rCBV] combined information, we also a specificity of 60% associated with a 95% sensitivity for detecting high-grade tumors, with a negative predictive value of 60% and positive predictive value of 95%. Our work shows that joint analysis of microvascular and metabolic information is possible by combining PET and MR imaging data. However, we found that, in our patient population, the microvascular information given by MR did not bring information more discriminating than the metabolic information derived from PET only
Hotton, Gary. "PET studies on the effect of chronic intraputaminal glial cell line-derived neurotropic factor on fluro-l-dopa positron emission tomography in advanced parkinson's disease." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498282.
Rakshi, James. "Striatal and extra-striatal dopaminergic function in Parkinson's disease and the effect of dopamine agonist therapy on PD progression studies with 3D[¹â¸F]-dopa PET." Thesis, University of Aberdeen, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400667.
Pereira, Maurício dos Santos. "Análise de fatores inflamatórios na discinesia induzida por L-DOPA em modelo de camundongos: caracterização da enzima ciclooxigenase-2." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-24042018-181827/.
Parkinson\'s disease (PD) is the second most common neurodegenerative disease in world population. The development of motor impairments related to this disease occurs due to its pathophysiology, which mainly promotes the neurodegeneration of the dopaminergic neurons in the substantia nigra pars compacta. Studies suggest the involvement of inflammatory pathways that exacerbate cell death in the pathophysiology of PD. The neuroinflammatory phenomenon is characterized by the activation of central nervous system cells, such as neurons, microglia and astrocytes, in addition to proinflammatory mediators that are elevated in patients with PD, such as the enzyme cyclooxygenase-2 (COX-2), tumor necrosis factoralpha (TNF-?), interleukin 1? (IL-1?) and interleukin-6 (IL-6), among others. These factors are present in neuroanatomic structures such as striatum and substantia nigra pars compacta. Chronic treatment with L-DOPA, the precursor of the neurotransmitter dopamine, initially generates a reduction in the manifestation of motor symptoms in the vast majority of patients, but after a certain time of treatment, motor complications begin to appear, such as L-DOPAinduced dyskinesia (LID). The development and manifestation of LID may also accompany an abnormal inflammatory response. Data from our group suggest the enzyme COX-2 as one of the mediators of LID. Studies also point out that drugs that reduce LID are able to modulate COX-2 expression. Our objective, therefore, was to characterize the presence of proinflammatory factors/mechanisms in the injured striatum of mice treated with L-DOPA. For this purpose, the present study will be divided into three chapters. In the first chapter, we used the hemiparkinsonian mice model (lesioned with 6-hydroxydopamine) treated with LDOPA for different time periods (1, 7, 14 and 21 days) to observe the appearance of inflammatory factors in the striatum, such as the COX-2 enzyme, nuclear factor kappa-B (NF- ?B) and the expression and activity of glial cells, represented by astrocytes and microglia. In the second chapter, we demonstrated the potential of glial cells to produce cytokines and/or glutamate after stimulation with the major neurotransmitters involved with LID, dopamine (or its precursor L-DOPA) and glutamate. Finally, in the third chapter, we demonstrate the therapeutic potential of drugs used in the clinic with anti-inflammatory properties to reduce previously established LID. For this, we used cannabidiol (the active constituent of Cannabis, used for the treatment of epilepsy, among others) and celecoxib (a specific COX-2 activity inhibitor). The present study corroborates the existence of an inflammatory process in the injured striatum of parkinsonian mice, exacerbated by treatment with L-DOPA. The COX-2 enzyme may play a key role in the development of LID. Additionally, this work suggests that drugs clinically used with anti-inflammatory action may become possible therapeutic tools for the reduction of this disorder. In this way, we relate the production of inflammatory factors and the activation of glial cells to the perpetuation of an abnormal striatal postsynaptic activity that causes the \"maladaptative plasticity\" typical of LID.
Labadi, Adnan Ghaleb Mohammed al. "Nucleophilic aromatic substitution by [18F]fluoride and its applications to the synthesis of model precursors for the multi-step synthesis of the PET-tracer 6-[18F]fluoro-L-DOPA." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980292638.
Briche, Samir. "Etude des propriétés cristallographiques, physico-chimiques et optiques des polyphosphastes de terres rares de formule Ln(PO3)3 (Ln=Y,Lu) dopés en ions Eu3+ et Tb3+ élaborés par méthode sol-gel." Clermont-Ferrand 2, 2006. http://www.theses.fr/2006CLF21706.
Pultrone, Cristian Vincenzo <1982>. "Il ruolo della TC/PET con anti-3-18F-FACBC nella stadiazione dei pazienti affetti da neoplasia prostatica ad alto rischio e nella ristadiazione dei pazienti con ripresa biochimica dopo trattamento radicale." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/8126/1/Pultrone_Cristian_tesi.pdf.
Purpose: To compare the accuracy of 18F-FACBC and 11C-choline PET/CT in pre-operative staging of patients affected by prostate cancer and in patients radically treated for prostate cancer presenting with biochemical relapse. Methods: This prospective study was divided in two phases. In the “Phase I” we enrolled 100 consecutive patient radically treated for prostate cancer(PCa) and presenting with rising PSA. Of these 100 patients, 89 were included in the analysis with the following inclusion criteria: a)biochemical relapse; b)no hormonal therapy at the time of the scans. In the “Phase II” we enrolled 94 consecutive patients affected by PCa. Of these 94 patients, 80 were included in the analysis with the following inclusion criteria: a)High-risk PCa; b)no bone metastases c)no hormonal therapy. All patients underwent radical prostatectomy with lymphadenectomy. Sensitivity, specificity, PPV, NPV and accuracy were calculated for both the tracers. For phase I patients the standard of reference was follow-up at 1 year (including correlative imaging, PSA trend and pathology when available),for phase II patients was the histology. Results: In patients-based analysis sensitivity, specificity, PPV, NPV and accuracy for 11C-choline and 18F-FACBC PET/CT in restaging (phaseI) were: 32%vs37%, 40%vs67%, 90%vs97%, 3%vs4%, 32%vs38% respectively. Categorizing patients by PSA level (<1 ng/ml 28 patients, 1-2 ng/ml 28 patients, 2–3 ng/ml 11 patients, ≥3 ng/ml 22 patients) the number of patients with TP findings were generally higher with 18F-FACBC than with 11C-choline. In patients-based analysis sensitivity, specificity, PPV, NPV and accuracy for 11C-choline and 18F-FACBC PET/CT in staging (phaseII) were: 57.9%vs52.6%, 68.9%vs85.2%, 36.7%vs52.6%, 84%vs85.2%, 66.2%vs77.5% respectively. Conclusion: 18F-FACBC can be considered an alternative tracer to 11C-choline in the setting of patients with biochemical relapse after radical prostatectomy and in PCa staging. Last but not least thanks to its long half-life this radiotracer can be used also in PET Centers without cyclotron.
El, Masloumi Mohamed. "Photoluminescence et cristallochimie des polyphosphates de formule Na1-xAgxM(PO3)4 (M : la, Y) à l’état cristallisé ou vitreux." Thesis, Bordeaux 1, 2008. http://www.theses.fr/2008BOR13727/document.
This work focuses on keeping with the general pattern of investigations of physical-chemical properties of silver-polyphosphates to find new ways for devices such as lighting, visible range laser applications and radiophotoluminescence. The goal of this study aims at understanding the processes of Ag+ luminescence in Na1-xAgxLn(PO3)4 (Ln = La et Y) compounds which structure has been completely determinated. The luminescence of the single crystals is induced by Ag+ ions in isolated sites and close to hole centers (Ag2+) resulting in UV photosensitivity for the lanthanum crystals. The photoluminescence of the Na1-xAgxLa(PO3)4 glasses (glass-forming only) has been resolved owing to UV irradiation investigations and comparison with the luminescence of Na2-xAgxZnP2O7 glass. Both are also due to Ag+ ions in isolated sites
Chang-LongKao and 高彰隆. "One-Pot Synthesis of L-DOPA Imprinted Nanoparticles with Fluorescent Functionality for Controlled Release and Sensing Similar Molecules." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/82197460702930836284.
國立成功大學
化學系
103
The major goal of this dissertation is develop fluorescence resonance energy transfer tag and biomimetic materials for molecular recognition. The molecular recognition platform is based on molecular imprinting technology, micro-processes and nanotechnology, which can be applied to lead molecules, proteins and biological specimens screening, bio-imaging, on-line concentration, qualitatively and quantitatively analytical methods. The major study will be to synthesize fluorescent tag and modify all functionalized molecular imprinting materials to biocompatible materials. Those biocompatible materials are molecular probes and can friendly bind with lead molecules, proteins and biological specimens. Qualitative and quantitative analysis will be evaluated by ultraviolet-visible spectrometer, fluorescence spectrometer, flow cytometer, gas and liquid chromatography coupled with mass spectrometer. The fluorescence resonance energy transfer tag will assist the sensing system for high throughput screening by integrating our methodologies with combinatorial chemistry in the future. All development in this project is to expand its potential in analytical chemistry.
Zeich, Katrin [Verfasser]. "Detektion von Phäochromozytomen und rekurrenten medullären Schilddrüsenkarzinomen mit F18 DOPA PET-CT / Katrin Zeich." 2008. http://d-nb.info/100084210X/34.
Labadi, Adnan Ghaleb Mohammed al [Verfasser]. "Nucleophilic aromatic substitution by [18F]fluoride and its applications to the synthesis of model precursors for the multi-step synthesis of the PET-tracer 6-[18F]fluoro-L-DOPA = Anwendung der nukleophilen aromatischen Substitution mit [18F]Fluorid an Modell-Substanzen für die Mehrstufensynthese des PET-Tracers 6-[18F]Fluoro-L-DOPA / vorgelegt von Adnan Ghaleb Mohammed al-Labadi." 2006. http://d-nb.info/980292638/34.
Yu, Chin-Yi, and 余勁毅. "A Case-Control Study of Premotor Diagnosis of Parkinson’s Disease in Carriers of LRRK2 G2385R Variant: Using Olfactory Test, Transcranial Sonography of Substantia Nigra and [18F]-dopa PET as Diagnostic Tools." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/89021146799531595161.
國立臺灣大學
臨床醫學研究所
98
Parkinson’s disease(PD) is a relentlessly progressive neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra(SN). It is characterized by motor symptoms of bradykinesia, rest tremor and rigidity. Mutations in the gene leucine-rich repeat kinase 2 (LRRK2), located on chromosome 12p11.2-q13, are the most frequent causes of familial autosomal dominant PD. Recently genetic association studies identified LRRK2 G2385R variant is a common risk polymorphism for sporadic PD in the Chinese population. In vitro studies of transfected cells have proved that G2385R variant iss more vulnerable to oxidative stress and associated with a higher rate of apoptosis. Pathological studies have shown that at the time when PD motor symptoms appear, a significant amount with approximate 60% of dompaminergic neurons in the SN has already occurred. In the clinical aspects, hyposmia is considered as premotor sign of PD. Degeneration in the olfactory system has been also proved pathologically to be early in the stage of this degenerative disease. Moreover, based on in vivo PET and SPECT imaging of the dopaminergic system, the onset of dopaminergic neuronal loss antedates the motor symptoms of PD by approximately 4 to 6 years. Recently increased echogenicity of SN detected by transcranial sonography has been related to a functional impairment of the nigrostriatal system. It has also been proved to be a susceptibility marker for the development nigral injury that can be detected early in life prior to the onset of motor symptoms. These facts signify the importance of early diagnosis of PD in the premotor phase, in which neuroprotective measures can possibly intervene. With this background, we conducted this case-control cohort study in a hospital based cohort. We intended to evaluate various tools of premotor diagnosis with olfactory test, 18F-dopa PET and transcranial sonography of SN in the healthy subjects carrying LRRK2 G2385R variant, which has been proved to be specific for ethnic Han Chinese population. 526 healthy subjects were recruited from the PD center of National Taiwan University hospital for genetic screening of LRRK2 G2385R polymophism. Twenty four of them are G2385R variants. The prevalence rate of G2385R polymophism in our study group is 4.6%, which is similar to previous studies. Fifteen G2385R variants fulfilling the criteria of our study were then included for premotor diagnosis study. Meanwhile, fifteen aged and sex matched non-variants were included as control group. In the study of 18F-dopa PET, G2385R variants manifested a non-significant tendency to have decreased 18F-dopa uptake in the striatum, particularly in bilateral putamens. Our study has also proved that putaminal indicator of 18F-dopa PET imaging is a more sensitive indictor than the caudate indicator in terms of both clinical diagnosis and premotor diagnosis of PD. Furthermore, the G2385R variants did not show hyposmia or SN hyperechogenicity in comparison to the control group. It suggested that these two aforementioned premotor signs of PD seemed not related to LRRK G2385R polymophism. We should further follow particular subjects in this study, who presented with hyposmia, dopaminergic dysfunction shown by 18F-dopa PET, or SN hyperechoenicity to see if motor symptoms merge in the future and take in-time therapeutic intervention if PD is once diagnosed.
MARTINY, Federica. "Il diritto come reciprocità:un'analisi a partire dall'opera di Malinowski." Doctoral thesis, 2018. http://hdl.handle.net/11393/251117.
BOUSSOUS, Nabil. "Beni culturali e valore d’uso: conoscenza tacita, creatività e innovazione." Doctoral thesis, 2018. http://hdl.handle.net/11393/251082.
ROMAGNOLI, Valentina. "La gestione dei resi dei clienti come strumento per lo sviluppo del commercio elettronico delle aziende: il caso Santoni S.p.A." Doctoral thesis, 2018. http://hdl.handle.net/11393/251107.
RECCHI, Simonetta. "THE ROLE OF HUMAN DIGNITY AS A VALUE TO PROMOTE ACTIVE AGEING IN THE ENTERPRISES." Doctoral thesis, 2018. http://hdl.handle.net/11393/251122.