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1

Mazuryk, Olga, Przemysław Gajda-Morszewski, and Małgorzata Brindell. "Versatile Impact of Serum Proteins on Ruthenium(II) Polypyridyl Complexes Properties - Opportunities and Obstacles." Current Protein & Peptide Science 20, no. 11 (October 24, 2019): 1052–59. http://dx.doi.org/10.2174/1389203720666190513090851.

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Анотація:
Ruthenium(II) polypyridyl complexes have been extensively studied for the past few decades as promising anticancer agents. Despite the expected intravenous route of administration, the interaction between Ru(II) polypyridyl compounds and serum proteins is not well characterized and vast majority of the available literature data concerns determination of the binding constant. Ru-protein adducts can modify the biological effects of the Ru complexes influencing their cytotoxic and antimicrobial activity as well as introduce significant changes in their photophysical properties. More extensive research on the interaction between serum proteins and Ru(II) polypyridyl complexes is important for further development of Ru(II) polypyridyl compounds towards their application in anticancer therapy and diagnostics and can open new opportunities for already developed complexes.
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2

O’Neill, Luke, Laura Perdisatt, and Christine O’Connor. "Structure-Property Relationships for a Series of Ruthenium(II) Polypyridyl Complexes Elucidated through Raman Spectroscopy." Journal of Spectroscopy 2018 (November 1, 2018): 1–11. http://dx.doi.org/10.1155/2018/3827130.

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A series of ruthenium polypyridyl complexes were studied using Raman spectroscopy supported by UV/Vis absorption, luminescence spectroscopy, and luminescence lifetime determination by time-correlated single photon counting (TCSPC). The complexes were characterised to determine the influence of the variation of the conjugation across the main polypyridyl ligand. The systematic and sequential variation of the main polypyridyl ligand, 2-(4-formylphenyl)imidazo[4,5-f][1,10]phenanthroline (FPIP), 2-(4-cyanophenyl)imidazo[4,5-f][1,10]phenanthroline (CPIP), 2-(4-bromophenyl)imidazo[4,5-f][1,10]phenanthroline (BPIP), and 2-(4-nitrophenyl)imidazo[4,5-f][1,10]phenanthroline (NPIP) ligands, allowed the monitoring of very small changes in the ligands electronic nature. Complexes containing a systematic variation of the position (para, meta, and ortho) of the nitrile terminal group on the ligand (the para being 2-(4-cyanophenyl)imidazo[4,5-f][1,10]phenanthroline (p-CPIP), the meta 2-(3-cyanophenyl)imidazo[4,5-f][1,10]phenanthroline (m-CPIP) and 2-(2-cyanophenyl)imidazo[4,5-f][1,10]phenanthroline (o-CPIP)) were also characterised. Absorption, emission characteristics, and luminescence yields were calculated and correlated with structural variation. It was found that both the electronic changes in the aforementioned ligands showed very small spectral changes with an accompanying complex relationship when examined with traditional electronic methods. Stokes shift and Raman spectroscopy were then employed as a means to directly gauge the effect of polypyridyl ligand change on the conjugation and vibrational characteristics of the complexes. Vibrational coherence as measured as a function of the shifted frequency of the imizodale bridge was shown to accurately describe the electronic coherence and hence vibrational cooperation from the ruthenium centre to the main polypyridyl ligand. The well-defined trends established and elucidated though Raman spectroscopy show that the variation of the polypyridyl ligand can be monitored and tailored. This allows for a greater understanding of the electronic and excited state characteristics of the ruthenium systems when traditional electronic spectroscopy lacks the sensitivity.
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3

Lu, Xiaoqing, Shuxian Wei, Chi-Man Lawrence Wu, Ning Ding, Shaoren Li, Lianming Zhao, and Wenyue Guo. "Theoretical Insight into the Spectral Characteristics of Fe(II)-Based Complexes for Dye-Sensitized Solar Cells—Part I: Polypyridyl Ancillary Ligands." International Journal of Photoenergy 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/316952.

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The design of light-absorbent dyes with cheaper, safer, and more sustainable materials is one of the key issues for the future development of dye-sensitized solar cells (DSSCs). We report herein a theoretical investigation on a series of polypyridyl Fe(II)-based complexes of FeL2(SCN)2, [FeL3]2+, [FeL′(SCN)3]-, [FeL′2]2+, and FeL′′(SCN)2(L = 2,2′-bipyridyl-4,4′-dicarboxylic acid, L′ = 2,2′,2″-terpyridyl-4,4′,4″-tricarboxylic acid, L″= 4,4‴-dimethyl-2,2′ : 6′,2″ :6″,2‴-quaterpyridyl-4′,4″-biscarboxylic acid) by density functional theory (DFT) and time-dependent DFT (TD-DFT). Molecular geometries, electronic structures, and optical absorption spectra are predicted in both the gas phase and methyl cyanide (MeCN) solution. Our results show that polypyridyl Fe(II)-based complexes display multitransition characters of Fe → polypyridine metal-to-ligand charge transfer and ligand-to-ligand charge transfer in the range of 350–800 nm. Structural optimizations by choosing different polypyridyl ancillary ligands lead to alterations of the molecular orbital energies, oscillator strength, and spectral response range. Compared with Ru(II) sensitizers, Fe(II)-based complexes show similar characteristics and improving trend of optical absorption spectra along with the introduction of different polypyridyl ancillary ligands.
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4

Nandhini, T., K. R. Anju, V. M. Manikandamathavan, V. G. Vaidyanathan, and B. U. Nair. "Interactions of Ru(ii) polypyridyl complexes with DNA mismatches and abasic sites." Dalton Transactions 44, no. 19 (2015): 9044–51. http://dx.doi.org/10.1039/c5dt00807g.

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5

Amiri, Mona, Octavio Martinez Perez, Riley T. Endean, Loorthuraja Rasu, Prabin Nepal, Shuai Xu, and Steven H. Bergens. "Solid-phase synthesis and photoactivity of Ru-polypyridyl visible light chromophores bonded through carbon to semiconductor surfaces." Dalton Transactions 49, no. 29 (2020): 10173–84. http://dx.doi.org/10.1039/d0dt01776k.

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6

Race, N. A., W. Zhang, M. E. Screen, B. A. Barden, and W. R. McNamara. "Iron polypyridyl catalysts assembled on metal oxide semiconductors for photocatalytic hydrogen generation." Chemical Communications 54, no. 26 (2018): 3290–93. http://dx.doi.org/10.1039/c8cc00453f.

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7

Pierroz, Vanessa, Riccardo Rubbiani, Christian Gentili, Malay Patra, Cristina Mari, Gilles Gasser, and Stefano Ferrari. "Dual mode of cell death upon the photo-irradiation of a RuIIpolypyridyl complex in interphase or mitosis." Chemical Science 7, no. 9 (2016): 6115–24. http://dx.doi.org/10.1039/c6sc00387g.

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8

Liu, Ze-Yu, Jin Zhang, Yan-Mei Sun, Chun-Fang Zhu, Yan-Na Lu, Jian-Zhong Wu, Jing Li, Hai-Yang Liu, and Yong Ye. "Photodynamic antitumor activity of Ru(ii) complexes of imidazo-phenanthroline conjugated hydroxybenzoic acid as tumor targeting photosensitizers." Journal of Materials Chemistry B 8, no. 3 (2020): 438–46. http://dx.doi.org/10.1039/c9tb02103e.

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9

Martin, Aaron, Aisling Byrne, Ciarán Dolan, Robert J. Forster, and Tia E. Keyes. "Solvent switchable dual emission from a bichromophoric ruthenium–BODIPY complex." Chemical Communications 51, no. 87 (2015): 15839–41. http://dx.doi.org/10.1039/c5cc07135f.

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10

Leem, Gyu, Shahar Keinan, Junlin Jiang, Zhuo Chen, Toan Pho, Zachary A. Morseth, Zhenya Hu, et al. "Ru(bpy)32+ derivatized polystyrenes constructed by nitroxide-mediated radical polymerization. Relationship between polymer chain length, structure and photophysical properties." Polymer Chemistry 6, no. 47 (2015): 8184–93. http://dx.doi.org/10.1039/c5py01289a.

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11

Yamaguchi, Eiji, Nao Taguchi, and Akichika Itoh. "Ruthenium polypyridyl complex-catalysed aryl alkoxylation of styrenes: improving reactivity using a continuous flow photo-microreactor." Reaction Chemistry & Engineering 4, no. 6 (2019): 995–99. http://dx.doi.org/10.1039/c9re00061e.

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12

Margonis, Caroline M., Marissa Ho, Benjamin D. Travis, William W. Brennessel, and William R. McNamara. "Iron polypyridyl complex adsorbed on carbon surfaces for hydrogen generation." Chemical Communications 57, no. 62 (2021): 7697–700. http://dx.doi.org/10.1039/d1cc02131a.

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13

Notaro, Anna, and Gilles Gasser. "Monomeric and dimeric coordinatively saturated and substitutionally inert Ru(ii) polypyridyl complexes as anticancer drug candidates." Chemical Society Reviews 46, no. 23 (2017): 7317–37. http://dx.doi.org/10.1039/c7cs00356k.

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14

Li, Shuang, Gang Xu, Yuhua Zhu, Jian Zhao, and Shaohua Gou. "Bifunctional ruthenium(ii) polypyridyl complexes of curcumin as potential anticancer agents." Dalton Transactions 49, no. 27 (2020): 9454–63. http://dx.doi.org/10.1039/d0dt01040e.

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15

Martínez-Alonso, Marta, and Gilles Gasser. "Ruthenium polypyridyl complex-containing bioconjugates." Coordination Chemistry Reviews 434 (May 2021): 213736. http://dx.doi.org/10.1016/j.ccr.2020.213736.

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16

Banerjee, Tanmay, Abul Kalam Biswas, Tuhin Subhra Sahu, Bishwajit Ganguly, Amitava Das, and Hirendra Nath Ghosh. "New Ru(ii)/Os(ii)-polypyridyl complexes for coupling to TiO2 surfaces through acetylacetone functionality and studies on interfacial electron-transfer dynamics." Dalton Trans. 43, no. 36 (2014): 13601–11. http://dx.doi.org/10.1039/c4dt01571a.

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17

Taheri, Atefeh, and Gerald J. Meyer. "Temperature dependent iodide oxidation by MLCT excited states." Dalton Trans. 43, no. 47 (2014): 17856–63. http://dx.doi.org/10.1039/c4dt01683a.

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18

Poynton, Fergus E., Sandra A. Bright, Salvador Blasco, D. Clive Williams, John M. Kelly, and Thorfinnur Gunnlaugsson. "The development of ruthenium(ii) polypyridyl complexes and conjugates forin vitrocellular andin vivoapplications." Chemical Society Reviews 46, no. 24 (2017): 7706–56. http://dx.doi.org/10.1039/c7cs00680b.

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19

Liao, Xiangwen, Guijuan Jiang, Jintao Wang, Xuemin Duan, Zhouyuji Liao, Xiaoli Lin, Jihong Shen, Yanshi Xiong, and Guangbin Jiang. "Two ruthenium polypyridyl complexes functionalized with thiophen: synthesis and antibacterial activity against Staphylococcus aureus." New Journal of Chemistry 44, no. 40 (2020): 17215–21. http://dx.doi.org/10.1039/d0nj02944k.

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20

Sun, Qinchao, Bogdan Dereka, Eric Vauthey, Latévi M. Lawson Daku, and Andreas Hauser. "Ultrafast transient IR spectroscopy and DFT calculations of ruthenium(ii) polypyridyl complexes." Chemical Science 8, no. 1 (2017): 223–30. http://dx.doi.org/10.1039/c6sc01220e.

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21

Cardin, Christine J., John M. Kelly, and Susan J. Quinn. "Photochemically active DNA-intercalating ruthenium and related complexes – insights by combining crystallography and transient spectroscopy." Chemical Science 8, no. 7 (2017): 4705–23. http://dx.doi.org/10.1039/c7sc01070b.

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22

Queyriaux, N., E. Giannoudis, C. D. Windle, S. Roy, J. Pécaut, A. G. Coutsolelos, V. Artero, and M. Chavarot-Kerlidou. "A noble metal-free photocatalytic system based on a novel cobalt tetrapyridyl catalyst for hydrogen production in fully aqueous medium." Sustainable Energy & Fuels 2, no. 3 (2018): 553–57. http://dx.doi.org/10.1039/c7se00428a.

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23

Conti, Luca, Silvia Ciambellotti, Gina Elena Giacomazzo, Veronica Ghini, Lucrezia Cosottini, Elisa Puliti, Mirko Severi, et al. "Ferritin nanocomposites for the selective delivery of photosensitizing ruthenium-polypyridyl compounds to cancer cells." Inorganic Chemistry Frontiers 9, no. 6 (2022): 1070–81. http://dx.doi.org/10.1039/d1qi01268a.

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24

Azar, Daniel F., Hassib Audi, Stephanie Farhat, Mirvat El-Sibai, Ralph J. Abi-Habib, and Rony S. Khnayzer. "Phototoxicity of strained Ru(ii) complexes: is it the metal complex or the dissociating ligand?" Dalton Transactions 46, no. 35 (2017): 11529–32. http://dx.doi.org/10.1039/c7dt02255g.

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25

Tripathy, Suman Kumar, Umasankar De, Niranjan Dehury, Satyanarayan Pal, Hyung Sik Kim та Srikanta Patra. "Dinuclear [{(p-cym)RuCl}2(μ-phpy)](PF6)2 and heterodinuclear [(ppy)2Ir(μ-phpy)Ru(p-cym)Cl](PF6)2 complexes: synthesis, structure and anticancer activity". Dalton Trans. 43, № 39 (2014): 14546–49. http://dx.doi.org/10.1039/c4dt01033g.

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26

Ryan, Gary J., Fergus E. Poynton, Robert B. P. Elmes, Marialuisa Erby, D. Clive Williams, Susan J. Quinn, and Thorfinnur Gunnlaugsson. "Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(ii)-polypyridyl conjugates." Dalton Transactions 44, no. 37 (2015): 16332–44. http://dx.doi.org/10.1039/c5dt00360a.

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27

Jella, Tejaswi, Malladi Srikanth, Rambabu Bolligarla, Yarasi Soujanya, Surya Prakash Singh, and Lingamallu Giribabu. "Benzimidazole-functionalized ancillary ligands for heteroleptic Ru(ii) complexes: synthesis, characterization and dye-sensitized solar cell applications." Dalton Transactions 44, no. 33 (2015): 14697–706. http://dx.doi.org/10.1039/c5dt02074c.

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28

Luo, Zuandi, Lianling Yu, Fang Yang, Zhennan Zhao, Bo Yu, Haoqiang Lai, Ka-Hing Wong, Sai-Ming Ngai, Wenjie Zheng, and Tianfeng Chen. "Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase." Metallomics 6, no. 8 (2014): 1480–90. http://dx.doi.org/10.1039/c4mt00044g.

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29

Zhao, Xueze, Mingle Li, Wen Sun, Jiangli Fan, Jianjun Du, and Xiaojun Peng. "An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells." Chemical Communications 54, no. 51 (2018): 7038–41. http://dx.doi.org/10.1039/c8cc03786h.

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30

Jakubaszek, Marta, Bruno Goud, Stefano Ferrari, and Gilles Gasser. "Mechanisms of action of Ru(ii) polypyridyl complexes in living cells upon light irradiation." Chemical Communications 54, no. 93 (2018): 13040–59. http://dx.doi.org/10.1039/c8cc05928d.

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31

Tripathy, Suman Kumar, Umasankar De, Niranjan Dehury, Paltan Laha, Manas Kumar Panda, Hyung Sik Kim, and Srikanta Patra. "Cyclometallated iridium complexes inducing paraptotic cell death like natural products: synthesis, structure and mechanistic aspects." Dalton Transactions 45, no. 38 (2016): 15122–36. http://dx.doi.org/10.1039/c6dt00929h.

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32

Gill, Martin R., Michael G. Walker, Sarah Able, Ole Tietz, Abirami Lakshminarayanan, Rachel Anderson, Rod Chalk, et al. "An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells." Chemical Science 11, no. 33 (2020): 8936–44. http://dx.doi.org/10.1039/d0sc02825h.

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33

Weder, Nicola, Benjamin Probst, Laurent Sévery, Ricardo J. Fernández-Terán, Jan Beckord, Olivier Blacque, S. David Tilley, Peter Hamm, Jürg Osterwalder, and Roger Alberto. "Mechanistic insights into photocatalysis and over two days of stable H2 generation in electrocatalysis by a molecular cobalt catalyst immobilized on TiO2." Catalysis Science & Technology 10, no. 8 (2020): 2549–60. http://dx.doi.org/10.1039/d0cy00330a.

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34

Qiu, Yuqing, Yuquan Feng, Qian Zhao, Hongwei Wang, Yingchen Guo, and Dongfang Qiu. "White light emission from a green cyclometalated platinum(ii) terpyridylphenylacetylide upon titration with Zn(ii) and Eu(iii )." Dalton Transactions 49, no. 32 (2020): 11163–69. http://dx.doi.org/10.1039/d0dt02336a.

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35

Singh, Vikram, Prakash Chandra Mondal, Megha Chhatwal, Yekkoni Lakshmanan Jeyachandran, and Michael Zharnikov. "Catalytic oxidation of ascorbic acid via copper–polypyridyl complex immobilized on glass." RSC Adv. 4, no. 44 (2014): 23168–76. http://dx.doi.org/10.1039/c4ra00817k.

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36

Yang, Jing, Qian Cao, Wei-Liang Hu, Rui-Rong Ye, Liang He, Liang-Nian Ji, Peter Z. Qin, and Zong-Wan Mao. "Theranostic TEMPO-functionalized Ru(ii) complexes as photosensitizers and oxidative stress indicators." Dalton Transactions 46, no. 2 (2017): 445–54. http://dx.doi.org/10.1039/c6dt04028d.

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37

Xiong, Zushuang, Jing-Xiang Zhong, Zhennan Zhao, and Tianfeng Chen. "Biocompatible ruthenium polypyridyl complexes as efficient radiosensitizers." Dalton Transactions 48, no. 13 (2019): 4114–18. http://dx.doi.org/10.1039/c9dt00333a.

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Анотація:
A biocompatible ruthenium polypyridyl complex has been rationally designed, which could self-assemble into nanoparticles in aqueous solution to enhance the solubility and biocompatibility, and could synergistically realize simultaneous cancer chemo-radiotherapy.
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38

Banerjee, Samya, Ila Pant, Imran Khan, Puja Prasad, Akhtar Hussain, Paturu Kondaiah, and Akhil R. Chakravarty. "Remarkable enhancement in photocytotoxicity and hydrolytic stability of curcumin on binding to an oxovanadium(iv) moiety." Dalton Transactions 44, no. 9 (2015): 4108–22. http://dx.doi.org/10.1039/c4dt02165g.

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39

De Vos, Arthur, Kurt Lejaeghere, Francesco Muniz Miranda, Christian V. Stevens, Pascal Van Der Voort, and Veronique Van Speybroeck. "Electronic properties of heterogenized Ru(ii) polypyridyl photoredox complexes on covalent triazine frameworks." Journal of Materials Chemistry A 7, no. 14 (2019): 8433–42. http://dx.doi.org/10.1039/c9ta00573k.

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40

Elgrishi, Noémie, Matthew B. Chambers, Xia Wang, and Marc Fontecave. "Molecular polypyridine-based metal complexes as catalysts for the reduction of CO2." Chemical Society Reviews 46, no. 3 (2017): 761–96. http://dx.doi.org/10.1039/c5cs00391a.

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41

Vilvamani, Narayanasamy, Tarkeshwar Gupta, Rinkoo Devi Gupta, and Satish Kumar Awasthi. "Bottom-up molecular-assembly of Ru(ii)polypyridyl complex-based hybrid nanostructures decorated with silver nanoparticles: effect of Ag nitrate concentration." RSC Adv. 4, no. 38 (2014): 20024–30. http://dx.doi.org/10.1039/c4ra01347f.

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42

Chen, Tianfeng, Wen-Jie Mei, Yum-Shing Wong, Jie Liu, Yanan Liu, Huang-Song Xie, and Wen-Jie Zheng. "Correction: Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers." MedChemComm 9, no. 4 (2018): 745. http://dx.doi.org/10.1039/c8md90010h.

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43

Zayat, Leonardo, Oscar Filevich, Luis M. Baraldo, and Roberto Etchenique. "Ruthenium polypyridyl phototriggers: from beginnings to perspectives." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 371, no. 1995 (July 28, 2013): 20120330. http://dx.doi.org/10.1098/rsta.2012.0330.

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Анотація:
Octahedral Ru(II) polypyridyl complexes constitute a superb platform to devise photoactive triggers capable of delivering entire molecules in a reliable, fast, efficient and clean way. Ruthenium coordination chemistry opens the way to caging a wide range of molecules, such as amino acids, nucleotides, neurotransmitters, fluorescent probes and genetic inducers. Contrary to other phototriggers, these Ru-based caged compounds are active with visible light, and can be photolysed even at 532 nm (green), enabling the use of simple and inexpensive equipment. These compounds are also active in the two-photon regime, a property that extends their scope to systems where IR light must be used to achieve high precision and penetrability. The state of the art and the future of ruthenium polypyridyl phototriggers are discussed, and several new applications are presented.
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44

Shi, Hongdong, Tiantian Fang, Yao Tian, Hai Huang, and Yangzhong Liu. "A dual-fluorescent nano-carrier for delivering photoactive ruthenium polypyridyl complexes." Journal of Materials Chemistry B 4, no. 27 (2016): 4746–53. http://dx.doi.org/10.1039/c6tb01070a.

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45

Eskandari, Arvin, Arunangshu Kundu, Chunxin Lu, Sushobhan Ghosh, and Kogularamanan Suntharalingam. "Synthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(ii)-polypyridyl complexes." Dalton Transactions 47, no. 16 (2018): 5755–63. http://dx.doi.org/10.1039/c8dt00577j.

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46

Akatsuka, Komi, Ryosuke Abe, Tsugiko Takase, and Dai Oyama. "Coordination Chemistry of Ru(II) Complexes of an Asymmetric Bipyridine Analogue: Synergistic Effects of Supporting Ligand and Coordination Geometry on Reactivities." Molecules 25, no. 1 (December 19, 2019): 27. http://dx.doi.org/10.3390/molecules25010027.

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Анотація:
The reactivities of transition metal coordination compounds are often controlled by the environment around the coordination sphere. For ruthenium(II) complexes, differences in polypyridyl supporting ligands affect some types of reactivity despite identical coordination geometries. To evaluate the synergistic effects of (i) the supporting ligands, and (ii) the coordination geometry, a series of dicarbonyl–ruthenium(II) complexes that contain both asymmetric and symmetric bidentate polypyridyl ligands were synthesized. Molecular structures of the complexes were determined by X-ray crystallography to distinguish their steric configuration. Structural, computational, and electrochemical analysis revealed some differences between the isomers. Photo- and thermal reactions indicated that the reactivities of the complexes were significantly affected by both their structures and the ligands involved.
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47

Soman, Suraj, Jennifer C. Manton, Jane L. Inglis, Yvonne Halpin, Brendan Twamley, Edwin Otten, Wesley R. Browne, Luisa De Cola, Johannes G. Vos, and Mary T. Pryce. "New synthetic pathways to the preparation of near-blue emitting heteroleptic Ir(iii)N6 coordinated compounds with microsecond lifetimes." Chem. Commun. 50, no. 49 (2014): 6461–63. http://dx.doi.org/10.1039/c4cc02249a.

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48

Byrne, Aisling, Christopher S. Burke, and Tia E. Keyes. "Precision targeted ruthenium(ii) luminophores; highly effective probes for cell imaging by stimulated emission depletion (STED) microscopy." Chemical Science 7, no. 10 (2016): 6551–62. http://dx.doi.org/10.1039/c6sc02588a.

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49

Viere, Erin J., Ashley E. Kuhn, Margaret H. Roeder, Nicholas A. Piro, W. Scott Kassel, Timothy J. Dudley, and Jared J. Paul. "Spectroelectrochemical studies of a ruthenium complex containing the pH sensitive 4,4′-dihydroxy-2,2′-bipyridine ligand." Dalton Transactions 47, no. 12 (2018): 4149–61. http://dx.doi.org/10.1039/c7dt04554a.

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50

Lenis-Rojas, Oscar, Catarina Roma-Rodrigues, Alexandra Fernandes, Andreia Carvalho, Sandra Cordeiro, Jorge Guerra-Varela, Laura Sánchez, et al. "Evaluation of the In Vitro and In Vivo Efficacy of Ruthenium Polypyridyl Compounds against Breast Cancer." International Journal of Molecular Sciences 22, no. 16 (August 18, 2021): 8916. http://dx.doi.org/10.3390/ijms22168916.

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The clinical success of cisplatin, carboplatin, and oxaliplatin has sparked the interest of medicinal inorganic chemistry to synthesize and study compounds with non-platinum metal centers. Despite Ru(II)–polypyridyl complexes being widely studied and well established for their antitumor properties, there are not enough in vivo studies to establish the potentiality of this type of compound. Therefore, we report to the best of our knowledge the first in vivo study of Ru(II)–polypyridyl complexes against breast cancer with promising results. In order to conduct our study, we used MCF7 zebrafish xenografts and ruthenium complexes [Ru(bipy)2(C12H8N6-N,N)][CF3SO3]2Ru1 and [{Ru(bipy)2}2(μ-C12H8N6-N,N)][CF3SO3]4Ru2, which were recently developed by our group. Ru1 and Ru2 reduced the tumor size by an average of 30% without causing significant signs of lethality when administered at low doses of 1.25 mg·L−1. Moreover, the in vitro selectivity results were confirmed in vivo against MCF7 breast cancer cells. Surprisingly, this work suggests that both the mono- and the dinuclear Ru(II)–polypyridyl compounds have in vivo potential against breast cancer, since there were no significant differences between both treatments, highlighting Ru1 and Ru2 as promising chemotherapy agents in breast cancer therapy.
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