Добірка наукової літератури з теми "Polyphenols and flavonoids"
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Статті в журналах з теми "Polyphenols and flavonoids":
1
Oosthuizen, Dewald, Neill Goosen, Maria Stander, Aliyu Ibrahim, Mary-Magdalene Pedavoah, Grace Usman, and Taiwo Aderinola. "Solvent Extraction of Polyphenolics from the Indigenous African Fruit Ximenia caffra and Characterization by LC-HRMS." Antioxidants 7, no. 8 (August 1, 2018): 103. http://dx.doi.org/10.3390/antiox7080103.
Анотація:
Indigenous and non-commercial fruits can be an important source of antioxidant polyphenols; however, the identity and content of polyphenols from non-commercial fruits are often poorly described. The study aimed to extract, identify, and quantify polyphenols from the skin of the indigenous Africa fruit Ximenia caffra, using solvent extraction. Three solvents (hexane, acetone, and 70% v/v ethanol) over three extraction times (30, 60 and 120 min) were used in a 32 full factorial experimental design to determine effects on polyphenol recovery, and individual polyphenolics were characterised using liquid chromatography high-resolution mass spectrometry (LC-HRMS). Ethanol was the most effective extraction solvent, and extracts had high levels of total phenolics and flavonoids (65 mg gallic and 40 mg catechin equivalents per gram dry sample respectively), and high antioxidant activity (18.2 mg mL−1 ascorbic acid equivalents). LC-HRMS positively identified 16 compounds, of which 14 were flavonoids including flavonoid glycosides, and indicated that concentrations of some flavonoids decreased for extraction times beyond 60 min. It was concluded that the fruit of Ximenia caffra is rich in natural polyphenolic antioxidants; the present work identified and quantified a number of these, while also establishing suitable solvent extraction conditions for the recovery of these potentially high-value compounds.
2
Yang, Mingyi, Lei Wang, Tarun Belwal, Xiaocheng Zhang, Hongyan Lu, Cunkun Chen, and Li Li. "Exogenous Melatonin and Abscisic Acid Expedite the Flavonoids Biosynthesis in Grape Berry of Vitis vinifera cv. Kyoho." Molecules 25, no. 1 (December 18, 2019): 12. http://dx.doi.org/10.3390/molecules25010012.
Анотація:
Grape polyphenols contributing to more than half of the global polyphenol market were well studied; however, how melatonin (MLT), a potential plant hormone, and abscisic acid (ABA) affects polyphenols profile is still poorly understood. To explore whether these hormones are involved in polyphenolic biosynthesis, grape (Vitis vinifera cv. Kyoho) was exposed to MLT, ABA, and NDGA (nordihydroguaiaretic acid, an ABA biosynthesis inhibitor) treatments, and 16 polyphenols were identified from grape extracts by high performance liquid chromatography quadrupole time of flight mass spectrometry (HPLC-Q-TOF-MS). Both exogenous MLT and ABA significantly enhanced the biosynthesis of each flavonol and flavanol component, especially catechin, which was almost increased double by 200 µM of MLT treatment. Furthermore, the expression of genes involved in flavonoid biosynthesis, including 4-coumaroyl-CoA synthase, chalcone synthase, flavonoid 3′-hydroxylase, anthocyanin 3′-methyltransferase, flavonol synthase, flavonoid-3-O-glucosyltransferase, and flavonoid 3′,5′-methyltransferase were highly up-regulated as well but were down-regulated by NDGA. The present study provided new insights for improving flavonoids accumulation in agricultural production and its underlying mechanism.
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Carmona-Hernandez, Juan Carlos, Mai Le, Ana María Idárraga-Mejía, and Clara Helena González-Correa. "Flavonoid/Polyphenol Ratio in Mauritia flexuosa and Theobroma grandiflorum as an Indicator of Effective Antioxidant Action." Molecules 26, no. 21 (October 25, 2021): 6431. http://dx.doi.org/10.3390/molecules26216431.
Анотація:
Studies on polyphenols and flavonoids in natural products reveal benefits in the prevention of multiple diseases. Proper extraction, treatment of extracts, and quantification of polyphenols and flavonoids demand attention from the scientific community in order to report more specific biological action. Total polyphenol content (TPC) and total flavonoid content (TFC) (measured at three different times) of ethanol, methanol and acetone extracts of Mauritia flexuosa (aguaje) and Theobroma grandiflorum (copoazú) fresh pulp, from the Colombian Amazon region, were evaluated with the purpose of focusing in the polyphenol/flavonoid proportion and its effective antioxidant activity. This objective could help to explain specific flavonoid biological action based on higher flavonoid proportion rather than higher total polyphenol content. Differences in extracting solvents resulted in statistically significant different yields; the highest TPC was observed with acetone 70% in Mauritia flexuosa and ethanol 80% for T. grandiflorum. The best flavonoid/polyphenol ratio in M. flexuosa was about 1:2.4 and 1:12.8 in T. grandiflorum and the antioxidant efficacy was proportionally higher for flavonoids extracted from T. grandiflorum. HPLC analysis revealed 54 µg/g of the flavonoid kaempferol in M. Flexuosa and 29 µg/g in T. grandiflorum. Further studies evaluating this proportionality, in seeds or peel of fruits, as well as, other specific biological activities, could help to understand the detailed flavonoid action without focusing on the high total polyphenol content.
4
Erzsébet, Varga, Fülöp Ibolya, and Croitoru Mircea Dumitru. "Determination of flavonoids and polyphenols in veterinary products." Bulletin of Medical Sciences 93, no. 1 (July 1, 2020): 33–37. http://dx.doi.org/10.2478/orvtudert-2020-0007.
Анотація:
Abstract According to the 8th Hungarian Pharmacopoeia, propylene glycol can be chosen as solvent over ethyl alcohol for use in food supplements, therefore, the concentration of flavonoids and polyphenols in medicinal plants is measured using propylene glycol extracts. Samples of seven products, used in veterinary medicine, known to be rich in polyphenols and flavonoids were chosen to verify the usefulness of propylene glycol as extraction solvent. The polyphenol measurements were carried out using the Folin-Ciocâlteu method and the total flavonoid content was established using the modified method from the 10th Romanian Pharmacopoeia, Cynarae folium monograph. Propylene glycol/water mixture (70%/30%), used as extraction solvent for medicinal plants rich in flavonoids and polyphenols, proved to be useful for extraction of these valuable active substances and correlates with the known amounts stated previously to be present in these vegetable materials. Results were in correlation with literature data, concentrations ranged between 0.05 and 0.07 mg/ml (immediately after preparation), 0.02 and 0.08 mg/ml (within six months following preparation) in case of flavonoids and 2.44 and 3.80 mg/ml (immediately after preparation), 1.20 and 2.18 mg/ml (within six months following preparation) in case of polyphenols.
5
BENZIDANE, Nadia, Ridha SMAHI, Boudjemaa ZABOUCHE, Abdelhalim MAKROUF, and Lekhmici ARRAR. "Phytochemical study and antimicrobial activity of Algerian Marrubium vulgare leaf and stem extracts." Journal of Drug Delivery and Therapeutics 10, no. 5 (September 15, 2020): 70–74. http://dx.doi.org/10.22270/jddt.v10i5.4353.
Анотація:
Marrubium vulgare is used worldwide as a source of food flavor and for medicinal purposes. The aim of this study is to investigate polyphenol and flavonoid contents of M. vulgare extracts and their antimicrobial activities. Extraction was conducted using methanol and hexane. The determination of polyphenol content was realized with folin ciocalteu method and flavonoids using AlCl3. Rouph characterization of these compounds was done with HPLC method. Activity against bacteria and fungi was also studied. Results showed that methanolic extracts of leaves (LME) and stems SME) contain relatively high levels of polyphenols ad flavonoids. Except for hexane extract, all extracts from leaves and stems possess antibacterial and antifungal effects especially against Staphyloccocus aureus and Candida albicans. This finding suggests that M. vulgare methanolic extracts could serve as a basic material for the preparation of antimicrobial drugs.
Keywords: Marrubium vulgare, polyphenols, flavonoids, antibacterial, antifungal activities.
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Petkovska, Ana, Viktor Gjamovski, and Marina Stefova. "Comparison of different extraction solvents for assay of the polyphenol content in the peel and pulp of 21 apple cultivars from Macedonia." Macedonian Journal of Chemistry and Chemical Engineering 35, no. 1 (April 18, 2016): 29. http://dx.doi.org/10.20450/mjcce.2016.871.
Анотація:
Apples (Malus domestica Borkh.) contain a large array of phenolic compounds belonging to flavonoids and non-flavonoids. This study systematically evaluates the polyphenolic content of 21 apple cultivars from the Republic of Macedonia, both commercial and autochthonous, applying spectrophotometric methods for the determination of total polyphenolic compounds, total flavonoids, total anthocyanins and total flavan-3-ols. The reliability of these methods was checked by confirming the method linearity and accuracy with standards and spiked samples. The efficiency of acetone, water, methanol and a mixture of methanol/water (90 : 10, V/V) as extraction solvents was compared. Evident differences between extracts obtained from freeze-dried apple peel and pulp, extracted with different solvents, and analyzed with the four spectrophotometric tests, were observed and discussed. The most satisfactory extraction efficiency was achieved using methanol/water (90 : 10, V/V) mixture. The results obtained from the methanol/water extracts illustrate evident differences between polyphenol contents and reveal the diversity in polyphenols, total flavonoid and flavanol composition between the assayed commercial and autochthonous cultivars. The maximum abundance of polyphenols was noticed in the peel of Tetovka and Livadarka cultivars (15.63 mg/g GAE and 14.85 mg/g GAE, respectively) and in the pulp of Pasalma, Tetovka and Livadarka cultivars (12.55 mg/g GAE, 11.45 mg/g GAE and 11.22 mg/g GAE, respectively).
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Matić, Petra, and Lidija Jakobek. "Spectrophotometric Folin-Ciocalteu and Aluminium Chloride Method Validation for the Determination of Phenolic Acid, Flavan-3-ol, Flavonol, and Anthocyanin Content." Croatian journal of food science and technology 13, no. 2 (December 15, 2021): 176–83. http://dx.doi.org/10.17508/cjfst.2021.13.2.06.
Анотація:
Spectrophotometric methods for the determination of total polyphenols and total flavonoids are often used because they are simple, sensitive, and precise. Before using these methods, they must be validated to ensure the quality of the obtained data and to prove that the method is suitable for its purpose. The aim of this study was to validate the spectrophotometric methods for total polyphenols and total flavonoids. The method for total polyphenols has been validated according to polyphenol standards, which belong to the groups of phenolic acids (p-hydroxybenzoic acid, sinapic acid, ferulic acid), flavan-3-ols ((-)-epicatechin), flavonols (myricetin, kaempferol), and anthocyanins (cyanidin-3-glucoside). For the validation of the method for total flavonoids, the same polyphenol standards belonging to flavan-3-ols, flavonols, and anthocyanins have been used. The validation parameters were linearity, sensitivity, limit of detection, limit of quantification, precision, and accuracy. The results of the validation for both methods were in acceptable ranges, except for kaempferol in the method for total flavonoids. In conclusion, these methods can be used for the determination of total polyphenols and total flavonoids by using calibration curves of studied polyphenol standards, except for the kaempferol standard in the method for total flavonoids, due to lower sensitivity
8
Ding, Kaixi, Wei Jiang, Huanan Jia, and Ming Lei. "Synergistically Anti-Multiple Myeloma Effects: Flavonoid, Non-Flavonoid Polyphenols, and Bortezomib." Biomolecules 12, no. 11 (November 7, 2022): 1647. http://dx.doi.org/10.3390/biom12111647.
Анотація:
Multiple myeloma (MM) is a clonal plasma cell tumor originating from a post-mitotic lymphoid B-cell lineage. Bortezomib(BTZ), a first-generation protease inhibitor, has increased overall survival, progression-free survival, and remission rates in patients with MM since its clinical approval in 2003. However, the use of BTZ is challenged by the malignant features of MM and drug resistance. Polyphenols, classified into flavonoid and non-flavonoid polyphenols, have potential health-promoting activities, including anti-cancer. Previous preclinical studies have demonstrated the anti-MM potential of some dietary polyphenols. Therefore, these dietary polyphenols have the potential to be alternative therapies in anti-MM treatment regimens. This systematic review examines the synergistic effects of flavonoids and non-flavonoid polyphenols on the anti-MM impacts of BTZ. Preclinical studies on flavonoids and non-flavonoid polyphenols-BTZ synergism in MM were collected from PubMed, Web of Science, and Embase published between 2008 and 2020. 19 valid preclinical studies (Published from 2008 to 2020) were included in this systematic review. These studies demonstrated that eight flavonoids (icariin, icariside II, (-)-epigallocatechin-3-gallate, scutellarein, wogonin, morin, formononetin, daidzin), one plant extract rich in flavonoids (Punica granatum juice) and four non-flavonoid polyphenols (silibinin, resveratrol, curcumin, caffeic acid) synergistically enhanced the anti-MM effect of BTZ. These synergistic effects are mediated through the regulation of cellular signaling pathways associated with proliferation, apoptosis, and drug resistance. Given the above, flavonoids and non-flavonoid polyphenols can benefit MM patients by overcoming the challenges faced in BTZ treatment. Despite the positive nature of this preclinical evidence, some additional investigations are still needed before proceeding with clinical studies. For this purpose, we conclude by providing some suggestions for future research directions.
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Hithamani, Gavirangappa, and Krishnapura Srinivasan. "Bioaccessibility of Polyphenols from Onion (Allium cepa) as Influenced by Domestic Heat Processing and Food Acidulants." Indian Journal of Nutrition and Dietetics 53, no. 4 (December 1, 2016): 391. http://dx.doi.org/10.21048/ijnd.2016.53.4.8398.
Анотація:
Polyphenols are gaining importance in view of their health beneficial influences. Onion (<em>Allium cepa</em>) was analyzed for total polyphenol and flavonoid contents and their bioaccessibility as influenced by heat processing and food acidulants. Total polyphenols in raw onion (2.17 mg/g) were increased by 50% upon roasting. Total flavonoids in onion (0.27 mg/g) remained unchanged in heat processing. Bio accessible polyphenols and flavonoids from onion were 0.96 and 0.02 mg/g respectively and open-pan boiling increased the bio accessible polyphenols from onion. Addition of food acidulants to onion altered the composition and concentration of phenolic compounds. Total bio accessible polyphenols of onion decreased by 15% in presence of lime juice, while the same increased from microwave heated onions by 21% in presence of amchur. Presence of lime juice decreased bio accessible polyphenols in native and pressure-cooked onion, while the same increased by 37% in roasted onion in presence of amchur. Bioaccessibility of quercetin from onion increased 6-fold in presence of amchur, while a few polyphenols viz., protocatechuic acid, syringic acid, rutin and myricetin became bio accessible in presence of these food acidulants. Amchur enhanced the bio accessible polyphenols from onion more than lime juice. Concentration of bio accessible polyphenols was higher upon open-pan boiling of onion. There was a qualitative as well as quantitative change in the phenolic composition on addition of the food acidulants. Since amchur enhances the concentration of bio accessible polyphenols more than lime juice, its use in food preparations could be a strategy to maximize bioavailability of polyphenols, especially flavonoids from onion.
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Kasprzak-Drozd, Kamila, Jarosław Mołdoch, Marek Gancarz, Agnieszka Wójtowicz, Iwona Kowalska, Tomasz Oniszczuk, and Anna Oniszczuk. "In Vitro Digestion of Polyphenolic Compounds and the Antioxidant Activity of Acorn Flour and Pasta Enriched with Acorn Flour." International Journal of Molecular Sciences 25, no. 10 (May 15, 2024): 5404. http://dx.doi.org/10.3390/ijms25105404.
Анотація:
Acorn flour is a rich source of nutrients and is beneficial to human health due to, among other things, its low glycemic index and polyphenol content. In order to obtain more accurate data on the levels and activities of the substances tested after ingestion and digestion, it may be beneficial to use a simulated in vitro digestion method. Therefore, the objective of the present study was to elucidate the content of polyphenols, individual phenolic acids, flavonoids and antiradical properties of acorn flour and pasta enriched with acorn flour before and after simulated in vitro gastrointestinal digestion. The results indicate that the total polyphenol content (TPC), flavonoid content and radical scavenging activity exhibited an increasing trend following the initial digestion stage and a decreasing trend following the second stage. Nevertheless, the levels of phenolic acids demonstrated an increase in both digestion phases. The digestion processes of polyphenols in acorn flour differ significantly from those in pasta. In the case of pasta, total polyphenols , phenolic acids and flavonoids, as well as free radical scavenging properties, demonstrated a decreasing trend following each digestion stage.
Дисертації з теми "Polyphenols and flavonoids":
1
Kavuru, Padmini. "Crystal engineering of flavonoids." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002463.
2
Oliveira, Eduardo de Jesus. "Development of methods for profiling flavonoids and their metabolites in biological fluids." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366790.
3
BALASUBRAMANIAN, SHREEKRIPA. "DOSE AND VEHICLE EFFECTS ON THE PENETRATION RATE OF SELECTED PLANT POLYPHENOLS THROUGH HUMAN SKIN." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1016481382.
4
Kurzová, Pavlína. "Izolace antibakteriálních sloučenin z kávové sedliny." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-433498.
Анотація:
Coffee grounds are one of the very valuable lignocellulosic wastes that have been able to be processed and used for isolated phenolic substances. Many phenolic substances isolated from lignocellulosic wastes have antimicrobial properties. Aim of this thesis is isolation phenolic substances from spent coffee grounds extract and their available antimicrobial properties. Two isolation ways were applied to receive phenolic substances from spent coffee grounds: 1) solvent extraction (hexane, 75% ethanol, 70% acetone, diethyl ether, and ethyl acetate) and 2) release of active substances by alcoholic fermentation. All isolated materials were characterized by the viewpoint of concentration of reducing sugars, polyphenols and flavonoids. Subsequently, their antimicrobial activity was determined by using agar diffusion and broth dilution methods. Two gram-positive bacteria (Bacillus subtilis and Micrococcus luteus), one gram-negative bacteria (Serratia marcescens) and two yeasts (Candida glabrata and Saccharomyces cerevisiae) were used for antimicrobial testing. High-performance liquid chromatography (HPLC) was used to identify phenolic substances in the extracts. First, the results showed that the isolated sample with the highest antimicrobial activity was 70% acetone extract. This extract contained chlorogenic acid, gallic acid, caffeic acid and coumaric acid according to HPLC. The ethyl acetate extract showed the lowest antimicrobial activity. Second, after lyophilization, the isolated materials also revealed high antimicrobial activity. The highest antimicrobial activity displayed the materials obtained by the extraction with 70% ethanol. This sample contained chlorogenic acid, gallic acid and caffeic acids. Next, samples with phenolic compounds were obtained by the alcoholic fermentation of spent coffee grounds. These samples showed similarly to the previous solution extracts significant antimicrobial activity. Interestingly, the unfiltered samples received directly after alcoholic fermentation also showed antifungal properties. The characterization of phenolic compounds by HPLC showed similarly as in previous examples that chlorogenic, caffeic and gallic acids were present in these samples.
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Ciburová, Alena. "Studium antimikrobiálních látek zázvoru." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2019. http://www.nusl.cz/ntk/nusl-401841.
Анотація:
For thousands of years ginger rhizomes are used in traditional Chinese medicine. Because of his significant pungent flavour is commonly used in foods and beverages all over the world. Nowadays many of the beneficial pharmacological positive effects of ginger rhizomes are identified. Their occurrence is due to the high concentration of bioactive compounds. This thesis is focused on analysing of occurrence of bioactive compounds such as polyphenols and flavonoids and their influence on antioxidation and antimicrobial properties of samples of fresh and dried ginger. The results show that for extraction of bioactive compounds in different ginger samples is more suitable to use different types of extraction solvents. The highest antioxidation activity was measured for macerate of 100% bio ginger tea from Sonnentor company in 96% ethanol. Antimicrobial properties were showed only for 100% bio ginger tea against gram-positive bacteria Microccocus luteus.
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Rezaee, Nasim. "In vitro assessment to evaluate the potential effects of polyphenol extracts from sorghum on Alzheimer’s disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2022. https://ro.ecu.edu.au/theses/2581.
Анотація:
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for most dementia cases. AD is characterised by extracellular deposition of amyloid-β (Aβ) protein plaques and intracellular neurofibrillary tangles (NFTs), composed of hyper-phosphorylated tau. Other common hallmarks of the disease include neuroinflammation, oxidative stress and mitochondrial dysfunction. AD currently affects more than 55 million people worldwide and this number is increasingly growing. It is the second leading cause of death in Australia and the seventh leading cause of death worldwide. Despite its increasing economic, health and social burden, there are currently no effective treatments that substantially slow or reverse the progression of the disease. Because of the limited success of drug clinical trials, attention has focussed on natural products, particularly polyphenols (PPs) as possible alternative therapies mainly due to their multi-modal neuroprotective actions and fewer side effects. Sorghum is one such important candidate. It is a underutilized grain that grows widely in Australia. A wide range of PPs, including phenolic acids and flavonoids are present in sorghum grain. However, no study has investigated its neuroprotective activities to date.
Aim: The overall objective of the current study was the in vitro investigation of the neuroprotective effect of PP-rich extracts from six different sorghum varieties (Shawaya short black-1 (Black), IS1311C(Brown), QL33/QL36(Red), B923296(Red), QL12(White) and QL33(Red) on AD hallmarks.
Method and results: The PPs were extracted from sorghum and the polyphenolic content has been assessed. The sorghum Shawaya short black-1 and IS1311C showed the highest level of phenolic and flavonoid content compared to the other varieties. Nine different PPs have been identified through the HPLC-DAD assay. Then, we continued the experiments at the cellular level. First, the extracts were tested on human BE (2)-M17 neuroblastoma cells to determine the highest concentration which is non-toxic. The protective effects of these non-toxic doses of the extracts were then investigated for their ability to preserve cell viability in an Aβ42-induced cell model of AD. All six extracts (dissolved in DMSO) increased cell viability, but QL33(2000 μg/ml) was the most potent extract, increasing viability by 28%. To further evaluate whether there is a synergistic effect, these extracts were tested as paired combinations. However, no synergistic effect was noted. In addition, the extracts had significant anti-Aβ aggregation effects as assessed by the thioflavin T assay (Th-T). Shawaya short black-1 and B923296 demonstrated the highest and lowest inhibition effects, respectively. The extracts also affected Aβ42-induced reactive oxygen species (ROS), tau proteins and mitochondrial dysfunction. Except for B923296, the other five sorghum extracts showed a significant reduction of ROS and mitochondrial superoxide. Sorghum extracts also decreased the Aβ-induced total tau, tau phosphorylated at threonine- 231 (pT231) and Serine-199(pS199) (except for B923296). Furthermore, most of the sorghum extracts restored the mitochondrial membrane potential (Δψm) and adenosine triphosphate (ATP).
Conclusion: Overall, the sorghum extracts attenuated Aβ42-induced toxicity through multiple mechanisms. These extracts possess compounds that have the potential therapeutic value for AD. However, further studies using other in vitro and in vivo models of AD are required to validate these findings.
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Tran, Dong tien. "Conception et synthèse de sondes moléculaires pour l'étude d'interactions polyphénol-protéine." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0443/document.
Анотація:
Les polyphénols sont des métabolites secondaires d’origine végétale. Ces substances naturelles connues pour leurs pouvoirs antioxydants et anti-radicalaires, contribuent à la protection de la santé humaine notamment contre les maladies cardiovasculaires et neurodégénératives, mais également contre certains cancers et diabètes. Dans certains cas, ces effets biologiques bénéfiques pour la santé pourraient également être liés à une interaction spécifique polyphénol-protéine peu étudiée à ce jour par manque d’outils moléculaires adaptés. Les travaux effectués au cours de cette thèse ont consisté à concevoir, à synthétiser et à évaluer des sondes moléculaires polyvalentes porteuses de polyphénols comme substrats d’affinité pour l’analyse des interactions polyphénol-protéine. Dans ce contexte, de nombreuses sondes arborant différents types de polyphénols ont été synthétisées. Ces différentes sondes pourront être utilisées en protéomique chimique du type "Affinity-Based Protein Profiling" (ABPP) pour identifier au sein d’un mélange complexe de protéines, une protéine ayant une affinité spécifique pour un polyphénol donné. Ces mêmes sondes permettront également d’étudier de manière qualitative les interactions d’un polyphénol avec une protéine donnée en temps réel par la technique de résonance plasmonique de surface (SPR)Polyphenols are plant secondary metabolites. These natural substances, known for their antioxidant and anti-free radical properties, generally contribute to the protection of human health not only against cardiovascular and neurodegenerative diseases, but also against certain cancers and diabetes. In some cases, these beneficial biological effects could also be related to specific polyphenol-protein interactions. However, studying this type of interactions has suffered from the lack of adequate molecular tools. The work carried out during this thesis has included designing, synthesizing and evaluating modulable polyfunctional molecular probes carrying polyphenols as affinity substrates to analyze polyphenol-protein interactions. In this context, various probes harboring different kinds of polyphenols were synthesized. These probes could be used in chemical proteomics following an “Affinity-Based Protein Profiling” approach (ABPP) to identify a protein within complex protein mixtures, which has a specific affinity with a given polyphenol. These probes will also allow studying the interactions of a polyphenol with a given protein in real time in a qualitative way by surface plasmon resonance (SPR)
8
Ghnimi, Wafa. "Étude phytochimique des extraits de deux Euphorbiaceae : Ricinus communis et Jatropha curcas. Évaluation de leur propriété anti-oxydante et de leur action inhibitrice sur l’activité de l'acétylcholinestérase." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0006/document.
Анотація:
Ce travail de recherche est centré sur la valorisation de deux Euphorbiacées : Ricinus communis et Jatropha curcas. La première est une espèce autochtone connue comme plante dont l’huile des graines est utilisée pour ses vertus cosmétiques quant à la deuxième, c’est une espèce allochtone récemment introduite à titre expérimental en Tunisie et connue comme plante bioénergetique. Pour le ricin huit populations Tunisiennes ont été étudiées: Riadh Andalous, Nefza, Béja, Nabeul, Hammamet, Bouficha, Khanguet Hajej et Aouled Amer. Quant au jatropha, le matériel végétal est récolté dans la station expérimentale de Nabeul (Tunisie). Il s’agit de huit populations qui proviennent d’Arusha en Tanzanie, de Mozambique, de Suriname et de Brésil à partir de cinq provenances à savoir : Paranà, Norte de Minas, Mato Grosso, Regiao sudeste et Vale do Jequitinhonha. Le travail comprend une première partie consacrée à une étude bibliographique. Une deuxième partie est consacrée aux matériels et méthodes utilisés et une dernière partie qui montre l’ensemble des résultats obtenues. Ainsi, les résultats montrent que les extraits des feuilles des populations des deux espèces étudiées sont plus riches en composés phénoliques que les extraits des racines. L’étude phytochimique a montré que le ricin contient surtout de l’acide gentisique. Quant au jatropha, il contient surtout de l’épicatechine et de la naringine. L’étude chimique des huiles fixes des deux espèces montrent que l’huile de ricin renferme essentiellement d’acide ricinoléique. Quant à l’huile de jatropha, elle contient deux acides gras en proportions majeures qui sont l’acide oléique et l’acide linoléique. L’évaluation des activités anti-oxydantes des extraits des deux espèces indique une corrélation positive entre ces activités et les teneurs en composés phénoliques. Par ailleurs, l’étude de l’activité anti-acétylcholinestérase des extraits testés montrent que ces extraits sont des inhibiteurs de l’AChE plus puissants que la galanthamine utilisée comme contrôle positif. Notre étude a confirmé que les différents extraits de ricin et de jatropha, autres que les huiles fixes, peuvent donc être exploités pour d’autres activités biologiques, parmi les quelles l’action inhibitrice de l’AChE une des principales cibles des traitements contre la maladie l’Alzheimer et le piégeage des radicaux libres, en raison de leur richesse en composés phénoliquesThe aim of this study is to promote two Euphorbiaceae plants the Ricinus communis and the Jatropha curcas, the first one is known for its oil used in the cosmetic products, whereas the second one is known especially for its seeds used in the production of biodiesel. For the castor plant, eight Tunisian populations are studied: Riadh Andalous, Nefza, Beja, Nabeul, Hammamet, Bouficha, Khanguet Hajej and Aouled Amer. For the jatropha, recently introduced in Tunisia, the plant material is collected from the Nabeul station (Tunisia). Eight populations coming from Arusha in Tanzania, Mozambique, Suriname and Brazil from regions of Paraná, Minas Norte, Mato Grosso, Regiao sudeste and Vale do Jequitinhonha are studied. In first, a bibliographic study is made. In second, the used materials and methods are cited. Fanilly, all the results are mentioned. The study shows that the phenolic compounds are higher in the leaves extracts than in the roots extracts for both species. The phytochemical study shows that the gentisic acid is the major phenolic compound identified in the castor plant extracts. In contrast, the epicatechin and the naringin are the most important phenolic compounds identified in the jatropha extracts. The GC-MS analysis reveals that the castor oil contains mainly the ricinoleic acid. For the jatropha oil, two major fatty acids are identified: the oleic and the linoleic acids. Results of the antioxidant properties of leaves and roots of both species indicate a positive correlation between the leaves and the roots activities and their contents of phenolic compounds. Furthermore, the anti-acetylcholinesterase activity of the tested extracts shows for the first time that some tested extracts are more active than the galantamine used as a positive control. Our study confirmed that, in addition to their oils, different extracts of the castor plant and the jatropha can be used for biological activities such as the scavenging free radicals and the inhibitory action of AChE enzyme, which is a major target for treatments against the Alzheimer's disease due to their high levels of phenolic compounds. Owing to the activities of the leaves and the roots extracts confirmed by this study, the agricultural exploitation of the castor plant and the jatropha can be economically more profitable
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Teutschbein, Liana Morais Vianna. "Atividade cicatrizante de três espécies adaptadas ao cerrado brasileiro em modelo experimental de úlceras dérmicas em coelhos com análise imunohistológica e morfológica." Universidade Federal de Juiz de Fora (UFJF), 2011. https://repositorio.ufjf.br/jspui/handle/ufjf/2468.
Анотація:
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O cerrado brasileiro é um dos maiores biomas de diversidade biológica do planeta, abrigando uma ampla variedade de espécies medicinais utilizadas como parte da tradição e costume das comunidades locais. Os objetivos deste estudo foram determinar os teores de polifenóis e flavonóides; avaliar a atividade antioxidante; correlacionar os teores de polifenóis e flavonóides entre si e com a atividade antioxidante e avaliar a atividade cicatrizantes de três espécies deste bioma: Lippia sidoides; Synadenium grantii e Stachytarpheta gesnerioides. Através dos extratos etanólicos (EE), obtidos das folhas, foram quantificados espectrofotometricamente os teores de polifenóis e de flavonóides e, ainda, avaliada a atividade antioxidante (DPPH) e as correlações. Os EE foram incorporados ao creme base (10% de L. sidoides; 10% de Synadenium grantii e 10% de Stachytarpheta gesnerioides) e avaliados quanto à atividade cicatrizante, empregando o modelo de indução de úlceras dérmicas em coelhos albinos da Nova Zelândia (machos 1.5-2.0 kg; n=6). As úlceras foram analisadas macroscopicamente quanto ao aspecto da lesão e a contração de sua área durante 10 dias. Após este período, foi feito estudo histológico em lâminas coradas com hematoxilina-eosina para comparação do número de células inflamatórias; fibroblastos; vasos sanguíneos; área de colágeno e área de matriz extracelular entre os grupos e imunoistoquímica com a contagem dos miofibroblastos. Foram realizadas análises estatísticas descritivas para avaliar a significância das diferenças entre as médias dos resultados dos grupos, foi aplicada a análise de variância (ANOVA) e teste post hoc de Tukey, utilizando o SPSS versão 14.0 e p < 0,05. Foi avaliada a correlação de Pearson entre os teores de polifenóis e flavonóides e entre esses teores e a atividade antioxidante. Todos os EE das espécies utilizadas apresentaram presença de polifenóis, flavonóides e atividade antioxidante. Foi demonstrada uma correlação positiva entre os teores de polifenóis e flavonóides e atividade antioxidante. Não foi observada diferença na contração da lesão quando comparados os grupos controle e tratados e em relação ao número de miofibroblastos os grupos testados foram estatisticamente similares ao controle positivo. O tratamento com L. sidoides apresentou número de vasos sanguíneos, área de colágeno e área de matriz extracelular similar ao controle positivo; o número de fibroblastos e células inflamatórias foi 24% (p=0,002) e 54% (p < 0,001) menor, respectivamente, em relação ao controle positivo. O tratamento com Synadenium grantii apresentou número de fibroblastos, área de colágeno e área de matriz extracelular semelhante ao controle positivo e reduziu o número de células inflamatórias (61%) e vasos sanguíneos (54%) (p < 0,001 para ambos), em relação ao controle positivo. O tratamento com Stachytarpheta gesnerioides apresentou número de fibroblastos; área de colágeno e área de matriz extracelular semelhante ao controle positivo e reduziu o número de células inflamatórias (65%, p < 0,001) e vasos sanguíneos (42%, p=0,005) em relação ao controle positivo. Em relação ao número de miofibroblastos, todos os tratamentos foram estatisticamente similares ao controle positivo. A análise conjunta dos resultados inéditos sugere a realização de novos estudos científicos relacionados à atividade cicatrizante de L. sidoides.
The Brazilian cerrado is one of the planet’s major biological diversity biomes, hosting a wide variety of medicinal plants used as part of the tradition and customs of local communities. The objectives of this study were to determine the levels of polyphenols and flavonoids; evaluate the antioxidant activity; correlate the levels of polyphenols and flavonoids among themselves and with the antioxidant activity and to evaluate the healing activity of the ethanol extracts (EE) of three species of the cerrado: Lippia sidoides, Synadenium grantii and Stachytarpheta gesnerioides. With the ethanol extracts (EE), obtained from leaves, it were spectrophotometrically quantified the concentrations of polyphenols and flavonoids, and it was also evaluated the antioxidant activity (DPPH) and their correlations. The EE obtained from the leaves were incorporated into the cream base (10% of L. sidoides, 10% of Synadenium grantii and 10% of Stachytarpheta gesnerioides) and their healing activity was evalluated. It was used as experimental model the induction of dermal ulcers in New Zealand albino rabbits (males 1.5-2.0 kg; n = 6). The ulcers were analyzed for the appearance of the lesion and the contraction of the wound area during 10 days. After this period, the histology was conducted using histological sections stained with hematoxylin-eosin to compare the number of inflammatory cells, fibroblasts and blood vessels and immunohistochemistry to compare the number of myofibroblasts among the experimental groups. Descriptive statistics analysis were conducted and, to assess the significance of differences between the mean results of groups, It was also applied the analysis of variance (ANOVA) and Tukey's post hoc test, using SPSS version 14.0 and p <0.05. It was evaluated the Pearson correlation between the levels of polyphenols and flavonoids and between these levels and the antioxidant activity. All the EE of the used species showed the presence of polyphenols, flavonoids and antioxidant activity. It was demonstrated a positive correlation among these constituents and antioxidant activity. No difference was observed in the contraction of the lesion when compared to the control and treated groups. At microscopic analysis, treatment with L. sidoides showed the number of blood vessels, collagen area and area of extracellular matrix similar to the positive control; the number of fibroblasts and inflammatory cells was 24% (p = 0.002) and 54% (p <0.001) lower, respectively, compared to positive control. Treatment with Synadenium grantii presented number of fibroblasts, collagen area and area of extracellular matrix similar to the positive control and reduced the number of inflammatory cells (61%) and blood vessels (54%) (p <0.001 for both) compared the positive control. Treatment with Stachytarpheta gesnerioides presented number of fibroblasts, collagen area and area of extracellular matrix similar to the positive control and reduced the number of inflammatory cells (65%, p <0.001) and blood vessels (42%, p = 0.005) compared the positive control. In relation to the myofibroblasts, all treatments presented number of myofibroblasts similar to the positive control A combined analysis of these results suggest to perform further scientific studies related to healing activity of L. sidoides.
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Achaintre, David. "Développement d’une nouvelle méthode analytique pour le dosage des polyphénols dans les fluides biologiques et application à l’épidémiologie du cancer dans la cohorte EPIC." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1239/document.
Анотація:
Les polyphénols sont un groupe de métabolites secondaires communément trouvés dans l’alimentation et plus de 500 composés différents sont retrouvés dans plus de 450 denrées alimentaires. Au cours des 30 dernières années, de nombreuses études in vitro et chez l’animal ont suggéré un rôle bénéfique des polyphénols dans des maladies chroniques comme le cancer 1-3. Les études épidémiologiques basées majoritairement sur des questionnaires alimentaires sont cependant plus contradictoires 4-6. De nouvelles méthodes sont requises pour quantifier un plus grand nombre de composés dans une même série afin de réaliser des études épidémiologiques à grande échelle. Le but de cette thèse est de développer des méthodes de quantification d’une large gamme de polyphénols représentatifs des principales classes et sous-classes de polyphénols dans le sang et urine, d’évaluer les excrétions urinaires de polyphénols et leurs associations avec la consommation d’aliments source dans une population Européenne, d’évaluer les concentrations dans le sang dans une étude cas-témoin sur cancer colorectal dans l’étude prospective européenne sur le cancer et la nutrition (EPIC). Après une brève présentation des polyphénols et du cancer colorectal dans le chapitre II, une méthode originale basée sur la dilution isotopique différentielle et l’analyse en spectrométrie de masse est développée pour quantifier 38 polyphénols dans l’urine et présentée dans le chapitre III. Cette méthode est basée sur un marquage différentiel en 12C et 13C des polyphénols grâce à une dérivatisation par les isotopes du chlorure de dansyl. Différentes conditions pour l’hydrolyse des polyphénols conjugués, l’extraction et la dérivatisation des aglycones ont été évaluées et la méthode a été validée pour la mesure de 37 polyphénols. Les niveaux d’excrétion urinaire de ces 37 polyphénols mesurés chez 475 individus de la cohorte EPIC issues de quatre pays européens sont présentés dans le chapitre IV. Une grande variabilité d’excrétion urinaire dans les quatre pays Européens a pu être montrée et des corrélations significatives avec la consommation de certains aliments source de ces composés ont été observées suggérant l’utilisation possible de plusieurs de ces polyphénols en tant que biomarqueurs de l’alimentation. Une méthode d’analyse pour les mêmes 37 polyphénols également basée sur la dilution isotopique différentielle est développée, validée et appliquée à 1618 échantillons dans la cohorte EPIC (chapitre V). Les changements majeurs en comparaison de la méthode sur la matrice urinaire sont essentiellement les difficultés d’hydrolyse des polyphénols conjugués et des effets de matrice importants mais réduits par la méthode de dilution isotopique. Enfin l’étude des associations entre l’exposition aux polyphénols mesurée à l’aide des marqueurs plasmatique avec le risque de cancer colorectal a été conduite dans une étude cas-témoin nichée dans la cohorte EPIC et est présentée dans le chapitre VI. Une association inverse entre les concentrations plasmatiques d’equol, et une association positive entre l’acide homovanillique et le risque de cancer du côlon ont été trouvées. Les résultats obtenus constituent une nouvelle base pour des applications futures dans le domaine de l’épidémiologie des polyphénolsPolyphenols are secondary plant metabolites found in diet and more than 500 different compounds are found in more than 450 foods. Along the last 30 years, many in vitro and animals studies have suggested a beneficial role of polyphenols in chronic diseases such as cancer. However, epidemiological studies based mainly on dietary questionnaires are inconsistent. New methodologies with broader polyphenol coverage are required to quantify a large diversity of compounds within large scale epidemiological studies.The goal of this thesis is to develop methods to quantify a large number of polyphenols representative of the main classes and sub-classes in blood and urine, evaluate urinary excretions of polyphenols and their association with food consumption in an European population, evaluate concentrations in blood in a nested case-control study on colorectal cancer within the European prospective investigation study on cancer and nutrition (EPIC).After a short presentation of polyphenols and colorectal cancer in chapter II, an original method based on differential isotopic dilution and analyse by tandem mass spectrometry is developed to quantify 38 polyphenols in urine and presented in chapter III. This method is based on differential 12C-/13C- isotope labelling of polyphenols through derivatisation with isotopic dansyl chloride reagents. Different conditions for enzymatic hydrolysis of conjugated polyphenols, extraction and dansylation of unconjugated aglycones have been tested, optimized and validated for the measure of 37 polyphenols.Urinary excretion levels of these 37 polyphenols in 475 subjects within EPIC cohort from 4 European countries are presented in chapter IV. Large urinary excretion variability in the 4 European countries has been shown and significant correlations with the consumption of specific food containing polyphenols have been observed suggesting the possible used of some polyphenols as biomarker for food consumption.A similar method on plasma for the 37 polyphenols, based on differential isotopic dilution, is developed, validated and applied to 1618 samples within the EPIC cohort (Chapter V). Main changes compared to the method developed on urine are essentially difficulties to hydrolyse conjugated polyphenols and huge matrix effects but reduced by the isotopic dilution method.Finally, the study on the association between polyphenols exposure measured owing to plasmatic marker with colorectal cancer risk has been driven in a nested case-control study within the EPIC cohort and is presented in chapter VI. An inverse association between plasmatic concentrations of equol, and a positive association between homovanillic acid and colon cancer risk have been found.Results obtained constitute a new approach for future applications in large scale epidemiology study on polyphenols
Книги з теми "Polyphenols and flavonoids":
1
Lester, Packer, ed. Flavonoids and other polyphenols. San Diego, Calif: Academic Press, 2001.
2
Neville, Vassallo, ed. Polyphenols and health: New and recent advances. New York: Nova Science Publishers, 2008.
3
Golubkina, Nadezhda, Elena Kekina, Anna Molchanova, and Sergey Nadezhkin. Antioxidants of plants and methods of their definition. ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1045420.
Анотація:
The monograph presents the most simple and widely used methods for determining the most important of plant antioxidants: vitamin C, polyphenols, carotenoids, capsaicin, and belinovich photosynthetic pigments, flavonoids, anthocyanins, alkaloids, tannins, and minerals antioxidant: selenium and iodine. Special attention is paid to methods of extraction of antioxidants, providing maximum extraction of antioxidants from plant material, and the correct selection of the most appropriate method of analysis of one or another component. Provides detailed information developed by the authors method of using thin layer chromatography to assess the carotenoid composition of tomatoes and peppers.
The data presented here include results of research conducted on the basis of FICO, as well as the latest developments of foreign scientists devoted to natural antioxidants and methods of their determination. Presented in this monograph methodology was successfully tested in the laboratory and analytical Department of PNCO in 2012-2018.
For students and teachers and all interested in horticulture and agriculture.
4
Flavonoids and Other Polyphenols. Elsevier, 2001. http://dx.doi.org/10.1016/s0076-6879(00)x0001-8.
5
Packer, Lester, and Helmut Sies. Flavonoids and Other Polyphenols. Elsevier Science & Technology Books, 2001.
6
Chedea, Veronica Sanda. Procyanidins: Characterisation, Antioxidant Properties and Health Benefits. Nova Science Publishers, Incorporated, 2016.
7
Tamanoi, Fuyuhiko, and S. Zahra Bathaie. Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids. Elsevier Science & Technology Books, 2014.
8
Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids. Elsevier, 2014. http://dx.doi.org/10.1016/c2013-0-12728-6.
9
Tamanoi, Fuyuhiko, and S. Zahra Bathaie. Natural Products and Cancer Signaling Vol. 36: Isoprenoids, Polyphenols and Flavonoids. Elsevier Science & Technology Books, 2014.
10
Sullivan, Ingrid. Proanthocyanidins: Food Sources, Antioxidant Properties and Health Benefits. Nova Science Publishers, Incorporated, 2015.
Частини книг з теми "Polyphenols and flavonoids":
1
Pengelly, Andrew. "Polyphenols - tannins and flavonoids." In The constituents of medicinal plants, 41–58. 3rd ed. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789243079.0003.
Анотація:
Abstract Polyphenol compounds are those with two or more benzene rings, with varying degrees of hydroxylation in each ring. The name has become almost synonymous with dietary antioxidants. In this chapter, readers were introduced to lignans and stilbenes, both examples of polyphenol compounds. The focus of this chapter is on the two largest subcategories of polyphenols such as tannins and flavonoids.
2
Hrazdina, Geza. "Biosynthesis of Flavonoids." In Plant Polyphenols, 61–72. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3476-1_4.
3
Bezuidenhoudt, Barend C. B., and Daneel Ferreira. "Enantioselective Synthesis of Flavonoids." In Plant Polyphenols, 143–65. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3476-1_9.
4
Garg, Satish Kumar, Amit Shukla, and Soumen Choudhury. "Polyphenols and Flavonoids." In Nutraceuticals in Veterinary Medicine, 187–204. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-04624-8_13.
5
Yáñez, Jaime A., Connie M. Remsberg, Jody K. Takemoto, Karina R. Vega-Villa, Preston K. Andrews, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies. "Polyphenols and Flavonoids: An Overview." In FLAVONOID PHARMACOKINETICS, 1–69. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118468524.ch1.
6
van Rensburg, Hendrik, Reinier J. J. Nel, Pieter S. van Heerden, Barend B. C. B. Bezuidenhoudt, and Daneel Ferreira. "Enantioselective Synthesis of Flavonoids: Dihydroflavonols and Flavan-3-ols." In Plant Polyphenols 2, 147–62. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4139-4_8.
7
Amoafo Mensah, Michael. "Polyphenols and Flavonoids Containing Food Spices." In Analysis of Food Spices, 69–105. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003279792-6.
8
Williamson, Gary, Geoff W. Plumb, and Maria T. Garcia-Conesa. "Glycosylation, Esterification, and Polymerization of Flavonoids and Hydroxycinnamates: Effects on Antioxidant Properties." In Plant Polyphenols 2, 483–94. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4139-4_26.
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Khairnar, Shubham J., Eknath D. Ahire, Mohini R. Jagtap, Khemchand R. Surana, Sanjay J. Kshirsagar, and Raj K. Keservani. "Nutritional Properties of Polyphenols." In Advances in Flavonoids for Human Health and Prevention of Diseases, 1–22. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003369813-1.
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Harald, A. Kühnel. "Elimination of Senescent Cells by Polyphenols and Flavonoids." In Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, 3–24. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5422-0_1.
Тези доповідей конференцій з теми "Polyphenols and flavonoids":
1
Zavodnik, I. B., E. A. Lapshina, T. V. Ilyich, A. G. Veiko, T. A. Kovalenia, and V. U. Buko. "REGULATORY, ANTIOXIDATIVE AND HEPATOPROTECTIVE EFFECTS OF PLANT POLYPHENOLS AND THEIR NANOSTRUCTURED COMPLEXES." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-255-258.
Анотація:
Flavonoids, secondary plant metabolites, demonstrate a wide range of biological and pharmacological activities. In our experiment, flavonoids and their complexes with cyclodextrins (10—100 gM) dose-dependently prevented lipid peroxidation of erythrocyte and mitochondrial membranes, inhibited oxidation of reduced glutathione, and modulated the proapoptotic process of the mitochondrial permeability transition pores formation, that depends on flavonoid lipophilicity and structures. Generation of maps of the electron density distribution in the quercetin molecule and the quercetin semiquinone radical shows that the active electronic orbitals of quercetin and its semiquinone radical are delocalized along the phenolic rings, which, in the case of a radical, increases radical stability. The quercetin-hydroxypropyl-e-cyclodextrin complex proved to be a more effective antioxidant.
2
Huang, X. L., M. C. Peng, J. X. Liu, Y. Lei, X. J. Yang, and Z. H. Wu. "Hot air drying characteristics and nutrients of apricot armeniaca vulgaris lam pretreated with Radio Frequency(RF)." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7524.
Анотація:
Apricot pretreated with RF and then dried with convective hot air at 65℃, 3.0m/s in this research. RF pretreatment time of 20, 30, 40 and 50min were chosen. Results showed that, there is only falling rate period during apricot hot air drying, and the drying rate of apricot is improved significantly; Herdenson and Pabis model is suitable for apricot hot air drying; retentions of flavonoids, polyphenols and Vc in dried apricot were higher than those of fresh apricot; when RF treating time was chosen 30mins, nutrients retentions of Vc, flavonoid and polyphenols were 0.9543mg/100g, 5.4089mg/100g and 7.3382mg/100g, separately. Keywords: apricot fruit, hot air drying, drying rate, nutrients, radio frequency
3
Dong, Qingqing, Yaxin Jiang, Qiutong Wang, Minmin Liu, Nan Wang, Hongpeng He, Hao Zhou, Tongcun Zhang, and Xuegang Luo. "Analysis on the polyphenols, flavonoids and antioxidant activities of broccoli." In 2017 Global Conference on Mechanics and Civil Engineering (GCMCE 2017). Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/gcmce-17.2017.58.
4
Petrov, Nikita Aleksandrovich, Yuliya Sergeevna Sidorova, Alla Alekseevna Kochetkova, and Vladimir Kimovich Mazo. "DEVELOPMENT AND IN VIVO EVALUATION OF COMPLEXES OF BIOLOGICALLY ACTIVE COMPOUNDS WITH BIOPOLYMER MATRICES." In NEW TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2021. http://dx.doi.org/10.47501/978-5-6044060-1-4.36.
Анотація:
The paper presents the results of a preclinical assessment of the effectiveness of food ingredients: a concentrate of blueberry leaf polyphenols sorbed on buckwheat flour, and a concentrate of phytoecdysteroid 20-hydroxyecdysone and quinoa grain flavonoids sorbed on chicken egg white.
5
Opris, Ocsana, Ildiko Lung, Adina Stegarescu, Otilia Culicov, Vladimir Todiras, and Maria-Loredana Soran. "The influence of abiotic stress factors on lettuce." In Scientific International Symposium "Plant Protection – Achievements and Perspectives". Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2023. http://dx.doi.org/10.53040/ppap2023.53.
Анотація:
This paper presents the influence of non-steroidal anti-inflammatory drugs (diclofenac, ibuprofen, and naproxen), antibiotics (ampicillin, ciprofloxacin), nanomaterials (CNT-COOH, CNT-MnO2 etc) and heavy metals (Cu, Cd etc) on the lettuce (Lactuca sativa L.). The evaluation of the impact of these pollutants on photosynthetic pigments, total polyphenols, antioxidant activity and the variation of multielement content was followed. From these studies it was observed that the VOCs emission rate increase with the increase of the pollutant concentration and the quantity of chlorophylls, carotenoids, polyphenols and flavonoids decrease. In conclusion, these can be employed as a stress signal of the plants or as biomarkers. All these information can be used for assessment the resistance and resilience of plants to environmental stressors and will be applied for plant protection.
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J. AJEENA, Saba, Zainab A. JABARAH, and Suhayla khalied MOHAMMED. "EVALUATION THE ANTIOXIDANT ACTIVITY OF ALEO VERA LEAVES EXTRACTS." In VII. INTERNATIONAL SCIENTIFIC CONGRESSOF PURE,APPLIEDANDTECHNOLOGICAL SCIENCES. Rimar Academy, 2023. http://dx.doi.org/10.47832/minarcongress7-8.
Анотація:
Certain chemical compounds, such as biologically active molecules, can be produced and found in high concentrations in plants. Aloe vera plant consists mainly of more than 90% water and many chemical compounds, such as polysaccharides, due to its ability to adapt to desert conditions and environments. More than 200 nutritional substances were found to be exist in aloe vera, including vitamins, enzymes, minerals, polysaccharides, lignin, antioxidants and amino acids. flavonoids and phenols, among the important compounds, play an important and vital role as antioxidants by their function as free radicals’ scavengers. The current research is aiming to investigate the value of total polyphenols , flavonoids and antioxidant activities of magnetized water, non-magnetized water and alcoholic extracts of fresh Aloe Vera leaves .The study showed that the extracts of ethanol and magnetized water are much better than non-magnetized water.
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Organ, Adina, Mariana Jian, Vitalie Cobzac, Natalia Birca, Tamara Cotelea, Octavian Cirimpei, Veaceslav Kulcitki, and Viorel Nacu. "Analytical studies on the fractionation products from lavender extracts." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab28.
Анотація:
Lavender (Lavandula angustifolia) is a widespread aromatic plant exploited globally for essential oil production. It is known that the remaining wastes after industrial processing are rich in secondary metabolites with relevant biological activities [1]. In particular, triterpenic acids have recently attracted the interest of scientific community because of their broad activity spectrum which makes them very attractive for the use in cosmetics and healthcare products as functional compounds. The aim of this study was isolation and analytical studies on different fractions obtained from Lavandula angustifolia ethanolic extracts. The vegetal plant material represented wastes generated on the extraction of essential oil at industrial scale. The obtained integral extracts were mixed with different organic solvents of different polarity in acid and basic medium, thus obtaining a series of fractions with different content of secondary metabolites. The fractions with a high content of triterpenic acids were selected by using thin layer chromatography. The analytical experiments included determination of total polyphenols with the Folin-Ciocâlteu reagent, quantitative determination of flavonoids, FRAP reducing capacity test and qNMR determination of oleanolic, ursolic, pomolic and rosmarinic acids. According to the obtained results fractions showing higher total polyphenols (495.59 mg EGA/g of extract) were also rich in flavonoids (343.01 mg catechin equivalent/g of extract) demonstrating relevant reducing capacity (386.67 mg EGA/g of extract) and high rosmarinic acid content (cca. 250 mg/g of extract). The triterpenic acids have been found to predominate in less polar fractions.
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Teneda-Llerena, William Fabián, Alvaro José Teneda-Espín, and Josemanuel Luna-Nemecio. "Consumption of polyphenols and flavonoids in the fermentation of cocoa (theobroma cacao L.) in Ecuador." In 1er Congreso Universal de las Ciencias y la Investigación Medwave 2022;. Medwave Estudios Limitada, 2022. http://dx.doi.org/10.5867/medwave.2022.s2.uta112.
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Sudirman, Muhamad Seto. "Effectiveness of Ficus Elastica Roxb. Ex Hornem Leaf Extract in Reducing Total Cholesterol Level in High Fat Induced Diet Wistar Male Rats." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.10.
Анотація:
ABSTRACT Background: Kebo rubber leaves (ficus elastica roxb) contain flavonoids, polyphenols, and tannins. Flavonoids in the leaves of ficus elastica roxb such as catechins, isoflavones are polyphenolic antioxidants from plant metabolites. The leaves of ficus elastica roxb are trusted and proven empirically in the community to reduce cholesterol levels in the blood. Mice choose animals because they are considered to have physiological similarities with humans. This study aimed to determine the effect of ethanol extract of ficus elastica roxb leaves on reducing total cholesterol level in male Swiss Webster mice. Subjects and Method: This was a quasi-experimental study conducted at Biology Laboratory of the Faculty of Agriculture, Fisheries and Biology, University of Bangka Belitung from April to June, 2017. A sample of 25 male Swiss Webster mice was selected at random and allocated into groups. The dependent variable was total cholesterol. The independent variable was the extract of ficus elastica rox. The data were tested by One-Way ANOVA. Result: There were statistically significant mean differences among the study groups (p= 0.002), indicating the effect of ethanol extract of Ficus Elastica Roxb leaves on reducing total cholesterol level in male Swiss Webster mice at various doses. Conclusion: There are statistically significant mean differences among the study groups, indicating the effect of ethanol extract of Ficus Elastica Roxb leaves on reducing total cholesterol level in male Swiss Webster mice at various doses. Keyword: Ethanol extract of Ficus Elastica Roxb leaves, total cholesterol, mice Correspondence: Muhamad Seto Sudirman. School of Health Polytechnic, Pangkalpinang. Email: MuhamadSeto@gmail.com DOI: https://doi.org/10.26911/the7thicph.05.10
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Christina, Daisy, Heri Hermansyah, Anondho Wijanarko, Etin Rohmatin, Muhamad Sahlan, Diah Kartika Pratami, and Abdul Mun’im. "Selection of propolis Tetragonula sp. extract solvent with flavonoids and polyphenols concentration and antioxidant activity parameters." In 2ND BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2017. Author(s), 2018. http://dx.doi.org/10.1063/1.5023967.
Звіти організацій з теми "Polyphenols and flavonoids":
1
Kanner, Joseph, Edwin Frankel, Stella Harel, and Bruce German. Grapes, Wines and By-products as Potential Sources of Antioxidants. United States Department of Agriculture, January 1995. http://dx.doi.org/10.32747/1995.7568767.bard.
Анотація:
Several grape varieties and red wines were found to contain large concentration of phenolic compounds which work as antioxidant in-vitro and in-vivo. Wastes from wine production contain antioxidants in large amounts, between 2-6% on dry material basis. Red wines but also white wines were found to prevent lipid peroxidation of turkey muscle tissues stored at 5oC. The antioxidant reaction of flavonoids found in red wines against lipid peroxidation were found to depend on the structure of the molecule. Red wine flavonoids containing an orthodihydroxy structure around the B ring were found highly active against LDL and membrane lipid peroxidation. The antioxidant activity of red wine polyphenols were also found to be dependent on the catalyzer used. In the presence of H2O2-activated myoglobin, the inhibition efficiency was malvidin 3-glucoside>catechin>malvidin>resveratol. However, in the presence of an iron redox cycle catalyzer, the order of effectiveness was resveratol>malvidin 3-glucoside = malvidin>catechin. Differences in protein binding were found to affect antioxidant activity in inhibiting LDL oxidation. A model protein such as BSA, was investigated on the antioxidant activity of phenolic compounds, grape extracts, and red wines in a lecithin-liposome model system. Ferulic acid followed by malvidin and rutin were the most efficient in inhibiting both lipid and protein oxidation. Catechin, a flavonal found in red-wines in relatively high concentration was found to inhibit myoglobin catalyzed linoleate membrane lipid peroxidation at a relatively very low concentration. This effect was studied by the determination of the by-products generated from linoleate during oxidation. The study showed that hydroperoxides are catalytically broken down, not to an alcohol but most probably to a non-radical adduct. The ability of wine-phenolics to reduce iron and from complexes with metals were also demonstrated. Low concentration of wine phenolics were found to inhibit lipoxygenase type II activity. An attempt to understand the bioavailability in humans of antocyanins from red wine showed that two antocyanins from red wine were found unchanged in human urine. Other antocyanins seems to undergo molecular modification. In hypercholesterolemic hamsters, aortic lipid deposition was significantly less in animals fed diets supplemented with either catechin or vitamin E. The rate of LDL accumulation in the carotid arteries was also significantly lower in the catechin and vitamin E animal groups. These results suggested a novel mechanism by which wine phenolics are associated with decreased risk of coronary heart diseases. This study proves in part our hypothesis that the "French Paradox" could be explained by the action of the antioxidant effects of phenolic compounds found at high concentration in red wines. The results of this study argue that it is in the interest of public health to increase the consumption of dietary plant falvonoids. Our results and these from others, show that the consumption of red wine or plant derived polyphenolics can change the antioxidant tone of animal and human plasma and its isolated components towards oxidative reactions. However, we need more research to better understand bioavailability and the mechanism of how polyphenolics affect health and disease.