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Добірка наукової літератури з теми "Poly(anhydride esters)"

Автор: Grafiati
Опубліковано: 6 вересня 2023

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Статті в журналах з теми "Poly(anhydride esters)"

1

Snyder, Sabrina S., Yue Cao, and Kathryn E. Uhrich. "Extrudable salicylic acid-based poly(anhydride-esters) for injectable drug releasing applications." Journal of Bioactive and Compatible Polymers 34, no. 2 (March 2019): 178–89. http://dx.doi.org/10.1177/0883911519834808.

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Анотація:
Injectable biomaterials have attracted more and more interest owing to their advantages over traditional open surgeries: minimal invasive procedure and ease of handling. Commonly used synthetic injectable polymers exhibited low drug loading and poor biodegradability. In this work, we describe a novel series of degradable copolymers comprising salicylic acid–based poly(anhydride-esters) and poly(ethylene glycol) subunits suitable for injectable drug releasing applications. By tuning the rheology properties, these salicylic acid–based poly(anhydride-esters) and poly(ethylene glycol) copolymers may function as injectable drug delivery vehicles that deliver salicylic acid at the injury site. These copolymers were designed to have glass transition temperatures (Tg) below 0ºC, resulting in extrudable polymers that behave like viscous fluids at room temperature. Salicylic acid–based poly(anhydride-esters) and poly(ethylene glycol) copolymers of different ratios (2:1, 1:1, and 1:2 salicylic acid–based poly(anhydride-esters) and poly(ethylene glycol)) were synthesized and characterized by nuclear magnetic resonance and Fourier-transform infrared spectroscopies. Their shear viscosities were determined both at room and physiological temperatures. The in vitro drug release profiles, cytotoxicity, and anti-inflammatory activities were assessed. The shear viscosities were found to compare favorably with current injectable barrier materials on the market.
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2

Schmeltzer, Robert C., Theodore J. Anastasiou, and Kathryn E. Uhrich. "Optimized Synthesis of Salicylate-based Poly( anhydride-esters)." Polymer Bulletin 49, no. 6 (March 1, 2003): 441–48. http://dx.doi.org/10.1007/s00289-003-0123-6.

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3

Carbone, Ashley L., MinJung Song, and Kathryn E. Uhrich. "Iodinated Salicylate-Based Poly(anhydride-esters) as Radiopaque Biomaterials." Biomacromolecules 9, no. 6 (June 2008): 1604–12. http://dx.doi.org/10.1021/bm8000759.

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4

Schmeltzer, Robert C., Kristine E. Schmalenberg, and Kathryn E. Uhrich. "Synthesis and Cytotoxicity of Salicylate-Based Poly(anhydride esters)." Biomacromolecules 6, no. 1 (January 2005): 359–67. http://dx.doi.org/10.1021/bm049544+.

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5

deRonde, Brittany M., Ashley L. Carbone, and Kathryn Uhrich. "Storage stability study of salicylate-based Poly(anhydride-esters)." Polymer Degradation and Stability 95, no. 9 (September 2010): 1778–82. http://dx.doi.org/10.1016/j.polymdegradstab.2010.05.008.

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6

Schmeltzer, Robert C., and Kathryn E. Uhrich. "Synthesis and characterization of antiseptic-based poly(anhydride-esters)." Polymer Bulletin 57, no. 3 (April 21, 2006): 281–91. http://dx.doi.org/10.1007/s00289-006-0561-z.

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7

Prudencio, Almudena, Jonathan J. Faig, MinJung Song, and Kathryn E. Uhrich. "Phenolic Acid-based Poly(anhydride-esters) as Antioxidant Biomaterials." Macromolecular Bioscience 16, no. 2 (October 1, 2015): 214–22. http://dx.doi.org/10.1002/mabi.201500244.

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8

Carbone, Ashley L., and Kathryn E. Uhrich. "Design and Synthesis of Fast-Degrading Poly(anhydride-esters)." Macromolecular Rapid Communications 30, no. 12 (May 11, 2009): 1021–26. http://dx.doi.org/10.1002/marc.200900029.

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9

Lv, Li, Yuanyuan Shen, Min Li, Xiaofen Xu, Mingna Li, Shengrong Guo, and Shengtang Huang. "Novel 4-Arm Poly(Ethylene Glycol)-Block-Poly(Anhydride-Esters) Amphiphilic Copolymer Micelles Loading Curcumin: Preparation, Characterization, and In Vitro Evaluation." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/507103.

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Анотація:
A novel 4-arm poly(ethylene glycol)-block-poly(anhydride-esters) amphiphilic copolymer (4-arm PEG-b-PAE) was synthesized by esterization of 4-arm poly(ethylene glycol) and poly(anhydride-esters) which was obtained by melt polycondensation ofα-,ω-acetic anhydride terminated poly(L-lactic acid). The obtained 4-arm PEG-b-PAE was characterized by1H-NMR and gel permeation chromatography. The critical micelle concentration of 4-arm PEG-b-PAE was 2.38 μg/mL. The curcumin-loaded 4-arm PEG-b-PAE micelles were prepared by a solid dispersion method and the drug loading content and encapsulation efficiency of the micelles were 7.0% and 85.2%, respectively. The curcumin-loaded micelles were spherical with a hydrodynamic diameter of 151.9 nm. Curcumin was encapsulated within 4-arm PEG-b-PAE micelles amorphously and released from the micelles, faster in pH 5.0 than pH 7.4, presenting one biphasic drug release pattern with rapid release at the initial stage and slow release later. The hemolysis rate of the curcumin-loaded 4-arm PEG-b-PAE micelles was 3.18%, which was below 5%. The IC50value of the curcumin-loaded micelles against Hela cells was 10.21 μg/mL, lower than the one of free curcumin (25.90 μg/mL). The cellular uptake of the curcumin-loaded micelles in Hela cell increased in a time-dependent manner. The curcumin-loaded micelles could induce G2/M phase cell cycle arrest and apoptosis of Hela cells.
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Faig, Jonathan J., Kervin Smith, Alysha Moretti, Weiling Yu, and Kathryn E. Uhrich. "One-Pot Polymerization Syntheses: Incorporating Bioactives into Poly(anhydride-esters)." Macromolecular Chemistry and Physics 217, no. 16 (June 23, 2016): 1842–50. http://dx.doi.org/10.1002/macp.201600115.

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Дисертації з теми "Poly(anhydride esters)"

1

Chaudhury, Kamalika. "Effect of ethyl oleate and oleic anhydride on metronidazole release from poly(ortho esters) films." Scholarly Commons, 1998. https://scholarlycommons.pacific.edu/uop_etds/515.

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In the present study, the effects of selected concentrations (0, 0.375, 0.75, 1.5 and 2.25% w/w) of ethyl oleate or oleic anhydride, the latentiated forms of catalyst oleic acid, were compared with regard to the release characteristics of metronidazole (1 0% w/w) from poly( ortho esters) films in distilled water at 3 7 °C. The rate of release of metronidazole from poly(miho esters) films was dependent on the ethyl oleate or oleic anhydride concentrations. The poly(ortho esters) films with adjuvants demonstrated slower drug release for all concentrations of ethyl oleate studied and for 0.375% and 0.75% w/w of oleic anhydride. The effects of drug loading (5, 7.5 and 10% w/w) and film thickness (150 to 400 !J.m) were also studied in the presence of 0.75 %w/w of either adjuvant. Increasing drug loading enhanced the rate of drug release from films of same thickness. However, variation of film thickness (150 to 400 !J.m) did not significantly alter the release profile possibly due to high concentration of the drug in the film (10% w/w). Gel permeation chromatography, scanning electron microscopy and near zero-order release, in vitro, suggested that the steady-state release of metronidazole from the poly( ortho esters) films following the burst effect occurred initially by a combination of diffusion and surface erosion of the polymer. Later, the release was further complicated by onset of bulk erosion of the polymer due to catalysis by oleic acid produced by ester or anhydride hydrolysis.
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2

Hung, Wei-Chih, and 洪維志. "Synthesis and biological properties of novel cationic poly(anhydride-co-ester)." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/29809365324367350689.

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Анотація:
碩士
嘉南藥理科技大學
生物科技系暨研究所
94
Water-degradable polymeric materials has already become the focus in recent years. It has been described for various technical and biomedical applications because of the biocompatibility and biodegradable. In this study, a novel cationic polymer, poly(anhydride-co-ester) (Pea-PA) containing quarternary amine groups in the backbone, was synthesized through the reaction between dicarboxylic acid (AMEDA) with amino groups in the backbone and excess acetyl chloride. The structure of Pea-PA was characterized by nuclear magnetic resonance (NMR), Fourier transform infrared (FT-IR) and gel permeation chromatography analysis (GPC). To evaluate their biological properties, we executed a series of experiments. The results revealed that Pea-PA can provide better cytotoxicity profiles than presently used polycation (PEI) due to the biodegradable and biocompatibility. It also can’t induce macrophages to produce abundant NO. Another important aspect of the biomaterial screening refers to their blood-compatibility behaviour and we provided some blood clotting and haemolysis ratio parameters of Pea-PA. Although Pea-PA was not enough positive charge to complex with DNA in the application of gene delivery. But we can use the blending technique to modify the defects and increase the buffering capacity of complex. The novel material (Pea-PA) would be expected low cytotoxicity because of their biodegradable and versatility in terms of chemical and physical properties and an interesting candidate for biomedical applications.
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Частини книг з теми "Poly(anhydride esters)"

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Cao, Yue, and Kathryn E. Uhrich. "Salicylic Acid-Based Poly(anhydride-esters): Synthesis, Properties, and Applications." In Green Polymer Chemistry: New Products, Processes, and Applications, 149–62. Washington, DC: American Chemical Society, 2018. http://dx.doi.org/10.1021/bk-2018-1310.ch011.

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2

Fogaça, R., M. A. Ouimet, L. H. Catalani, and K. E. Uhrich. "Bioactive-Based Poly(anhydride-esters) and Blends for Controlled Drug Delivery." In ACS Symposium Series, 27–37. Washington, DC: American Chemical Society, 2013. http://dx.doi.org/10.1021/bk-2013-1135.ch003.

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3

Carbone-Howell, A. L., M. A. Ouimet, and K. E. Uhrich. "Biodegradable, Bioactive-Based Poly(anhydride-esters) for Personal Care and Cosmetic Applications." In ACS Symposium Series, 145–55. Washington, DC: American Chemical Society, 2013. http://dx.doi.org/10.1021/bk-2013-1148.ch009.

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4

Chang, Ying-Chih, and Curtis W. Frank. "Chemical Grafting of Poly(L-glutamate) γ-Esters on Silicon (100) Surfaces by Vapor Polymerization ofN-Carboxy Anhydride Monomers." In ACS Symposium Series, 142–57. Washington, DC: American Chemical Society, 1998. http://dx.doi.org/10.1021/bk-1998-0695.ch011.

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5

"In vitro-in vivo comparison of timolol maleate release from buffered and unbuffered matrices of monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride)." In Pharmaceutical Technology: Controlled Drug Release Vol 2, 155–60. CRC Press, 1991. http://dx.doi.org/10.3109/9780203979099-23.

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