Дисертації з теми "PIG-1"
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Pillay, Santhoshan Thiagaraj. "Pig mucus as an inhibitory agent of HIV-1." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/26949.
Повний текст джерелаKong, Kok Choi. "Sphingosine 1-phosphate signalling in guinea pig airway smooth muscle." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248742.
Повний текст джерелаScher, Judy. "mt¦1 melatonin receptor localization in the human and guinea pig retina." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58867.pdf.
Повний текст джерелаPu, Helen Xiaochun. "Cloning and characterization of 11ß-hydroxysteroid dehydrogenase 1 (11ß-HSD1) in the guinea pig." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ30819.pdf.
Повний текст джерелаHarrison, Andrew Alan. "Characterisation of E-selectin and VCAM-1 expression in models of inflammation in the pig." Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336283.
Повний текст джерелаPierre, Andrew F. "The effect of complement inhibition with soluble complement receptor 1 (sCR1) on pig allo-transplant lung function." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29290.pdf.
Повний текст джерелаFoster, Jayne Louise Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "The microencapsulation and transplantation of fetal pig islet-like cell clusters: a potential therapy for type 1 diabetes." Awarded by:University of New South Wales. Clinical School - Prince of Wales Hospital, 2007. http://handle.unsw.edu.au/1959.4/40715.
Повний текст джерелаHidalgo, André Marubayashi. "Fine mapping and single nucleotide polymorphism effects estimation on pig chromosomes 1, 4, 7, 8, 17 and X." Universidade Federal de Viçosa, 2011. http://locus.ufv.br/handle/123456789/4753.
Повний текст джерелаCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
Mapeamento de loci de caracaterística quantitativas (QTL) geralmente resultam na detecção de regiões genômicas que explicam parte da variação quantitativa da característica. Entretanto essas regiões são muito amplas e não permitem uma acurada identificação dos genes. Dessa forma, torna-se necessário o estreitamento dos intervalos onde os QTL estão localizados. Com a seleção genômica ampla (GWS), foram desenvolvidas ferramentas estatísticas de forma a se estimar os efeitos de cada marcador. A partir dos valores desses efeitos, pode-se analisar quais são os marcadores de maiores efeitos. Assim, objetivou-se realizar o mapeamento fino dos cromossomos suínos 1, 4, 7, 8, 17, e X, usando marcadores microsatélites e polimorfismo de base única (SNP), em uma população F2 produzida pelo cruzamento de varrões da raça naturalizada brasileira Piau com fêmeas comerciais, associados com características de desempenho, carcaça, orgãos internos, cortes e qualidade de carne. Também objetivou-se estimar os efeitos dos marcadores SNP nas características que tiveram QTL detectados, analisar quais são os mais expressivos e verificar se eles estão localizados dentro do intervalo de confiança do QTL. Os QTL foram identificados por meio do método regressão por intervalo de mapeamento e as análises foram realizadas pelo software GridQTL. O efeito de cada marcador foi estimado pela regressão de LASSO Bayesiano, usando o software R. No total, 32 QTL foram encontrados ao nível cromossômico de significância de 5%, destes, 12 eram significativos ao nível cromossômico de 1% e 7 destes eram significativos ao nível genômico de 5%. Seis de sete QTL apresentaram marcadores de efeito expressivo dentro do intervalo de confiança do QTL. Resultados deste estudo confirmaram QTL de outros trabalhos e identificaram vários outros novos. Os resultados encontrados utilizando marcadores microsatélites junto com SNPs aumentaram a saturação do genoma levando a um menor intervalo de confiança dos QTL encontrados. Os métodos usados foram importantes para estimar os efeitos dos marcadores, e também para localizar aqueles com efeitos mais expressivos dentro do intervalo de confiança do QTL, validando os QTL encontrados pelo método da regressão.
Quantitative Trait Loci (QTL) mapping efforts often result in the detection of genomic regions that explain part of the quantitative trait variation. However, these regions are very large and do not allow accurate gene identification, hence the interval must be narrowed where the QTL was located. With the genome wide selection (GWS), many statistical tools have been developed in order to estimate the effects for each marker. With the marker effects values it is possible to analyze which markers have large effects. Hence, the objective of this investigation was to fine map pig chromosomes 1, 4, 7, 8, 17 and X, using microsatellites and SNP markers, in a F2 population produced by crossing naturalized Brazilian Piau boars with commercial females, associated with performance, carcass, internal organs, cut yields and meat quality traits. A further aim was to estimate the effects of single nucleotide polymorphism (SNP) markers on traits with detected QTL, analyze the most expressive ones and verify whether the markers with larger effects were indeed within the QTL confidence interval. QTL were identified by regression interval mapping using the GridQTL software. Individual marker effects were estimated by Bayesian LASSO regression using the R software. In total, 32 QTL for the studied traits were significant at the 5% chromosome-wide level, including 12 significant QTL at the 1% chromosome-wide level and 7 significant at the 5% genome-wide level. Six out of seven QTL with genome-wide significance had markers of large effect within their confidence interval. These results confirmed some previous QTL and identified numerous novel QTL for the investigated traits. Our results have shown that the use of microsatellites and SNP markers that increase the genome saturation lead to QTL of smaller confidence intervals. The methods used were also valuable to estimate the marker effects and to locate the most expressive markers within the QTL confidence interval, validating those QTL found by the regression method.
Santangelo, Kelly Susan. "Determining the role of interleukin-1β in the Hartley guinea pig model of primary osteoarthritis". The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299649441.
Повний текст джерелаWei, Hai [Verfasser], and Barbara [Akademischer Betreuer] Conradt. "pig-1 MELK and ced-3 Caspase cooperate to control cell polarity in the C. elegans NSM neuroblast / Hai Wei ; Betreuer: Barbara Conradt." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1188564161/34.
Повний текст джерелаWang, Jingping. "Contribution of ߦ1- and ߦ2-adrenergic receptors to the sympathetic stimulation of L-type calcium current in isolated guinea pig ventricular cardiomyocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq24939.pdf.
Повний текст джерелаGupta, Anubha. "Role of the Blood-Brain Barrier in Stereoselective Distribution and Delay in H1 Receptor Occupancy of Cetirizine in the Guinea Pig Brain." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6360.
Повний текст джерелаKhan, Shamila. "Therapeutic effect of Interlenkin-4 and Interleukin-1 receptor antagonist in Actinobacillus pleuropneumoniae challenged pigs." University of Sydney. Anatomy and Pathology, 2005. http://hdl.handle.net/2123/625.
Повний текст джерелаStefopoulou, Sofia N. "Studies on reproductive traits of the male pig with particular emphasis on artificial insemination of the female : 1. Growth and development aspects of the boar and factors affecting male fertility 2. Semen evaluation." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327421.
Повний текст джерелаMorillo, Alujas Alberto. "Estudio de la hormona IGF-I en cerdos: efecto de un producto de proteína de patata fermentada." Doctoral thesis, Universitat de Lleida, 2016. http://hdl.handle.net/10803/386547.
Повний текст джерелаEls objectius de la tesi van ser l'estudi i revisió dels actuals coneixements sobre el metabolisme i les accions d'IGF-I en la producció porcina i més específicament la investigació dels efectes que un suplement alimentari provinent de la fermentació de la proteïna de patata pot tenir sobre els nivells d'IGF-I en diferents estadis productius, i si aquestes modificacions tenen alguna repercussió pràctica sobre la producció. En l'estudi realitzat amb les truges lactants, l'objectiu va ser estudiar si l'addició a la dieta de les truges lactants durant 5 dies abans del deslletament i 5 dies post deslletament de la proteïna fermentada de patata amb o sense glucosa tenia algun efecte sobre els dies no productius entre el deslletament i la cobrició, sobre la fertilitat i sobre el nombre de garrins nascuts totals en el subsegüent part i si aquests paràmetres productius van estar relacionats amb nivells plasmàtics d'IGF-I. Per a això es va triar una granja altament productiva amb un alt estatus sanitari perquè es va considerar que era la millor opció per conèixer els efectes de la proteïna fermentada de patata sobre els paràmetres estudiats. Es van usar un total de 183 truges de 3 grups de truges deslletades de forma consecutiva i es van distribuir en 4 grups de tractament tenint en compte el cicle de part, el nombre de garrins deslletats en el cicle anterior i el nombre de garrins parits en el cicle actual. El tractament va consistir en l'addició de la proteïna de patata fermentada, amb i sense glucosa, que es va considerar com el control positiu i un grup de truges que va actuar com a control negatiu al qual no se li va subministrar cap producte. Els tractaments es van iniciar 5 dies abans del deslletament i van concloure 5 dies post deslletament. Es van registrar tots els paràmetres productius per assolir els objectius i es van obtenir mostres de sang d'un subgrup de truges per determinar el nivell d'IGF-I. No es van trobar diferències significatives pel que fa als nivells d'IGF-I en acabar els tractaments ni tampoc es van trobar diferències significatives en els paràmetres productius estudiats. Un resultat no contemplat en l'estudi però trobat en l'anàlisi va ser que les truges que van ser alletants durant la lactació en què es va iniciar el tractament tenien major nivell d'IGF-I que les que no ho van ser. Aquesta troballa confirma que el nivell d'IGF-I depèn l'estatus nutricional i metabòlic dels animals ja que les truges que van actuar com dides van tenir una despesa metabòlica menor que les que no ho van ser i van poder recuperar millor el seu status metabòlic. Malgrat això no van existir diferències de productivitat després del subsegüent part. En l'estudi amb els garrins lactants l'objectiu va ser estudiar l'efecte de l'administració oral de la proteïna fermentada de patata a garrins durant les primeres 12 hores després del naixement sobre els nivells plasmàtics d'IGF-I, sobre la mortalitat i sobre el guany de pes viu des del naixement al fins al deslletament. Aquest estudi es va realitzar en una granja amb productivitat mitjana, amb una sanitat considerada com habitual en la producció porcina i que podia ser catalogada com una granja estàndard. Es van usar 542 garrins nascuts en 3 grups consecutius de part. Els garrins van ser classificats segons el seu pes al naixement entre garrins grans, amb 1,2 kg de pes o més al naixement i garrins petits amb menys de 1,2 kg de pes al naixement perquè es va considerar que el pes al naixement podria ser una variable que influís en l'estudi. Es van distribuir en 4 grups de tractament dins de cada grup de pes. Els tractaments van consistir en el subministrament oral de la proteïna de patata fermentada bé en una sola dosificació (primer grup) o bé partida en mitja dosi separades d'un interval de 12 h (segon grup) subministrant a un tercer grup d'animals glicerol en una sola presa, grup que es va considerar com el control positiu. El quart grup va ser el control negatiu i els garrins d'aquest grup no van rebre cap tractament. No es van trobar diferències significatives de forma global ni dins de cada grup de pes en cap de les variables estudiades. Els nivells d'IGF-I van ser majors en els animals del grup de pes gran quan es van comparar amb els garrins petits als 7 dies de l'estudi, però no al finalitzar el mateix. En l'estudi amb els garrins deslletats, l'objectiu va ser estudiar si l'addició a la dieta de garrins de proteïna fermentada de patata després de la seva deslletament en diferents proporcions podia reemplaçar l'ús de plasma porcí i si les modificacions estaven relacionades amb els nivells plasmàtics d'IGF-I. Aquest estudi es va realitzar en una granja de transició. Els garrins provenien de la granja utilitzada en l'estudi de garrins lactants. Es van realitzar dos estudis consecutius, el primer per conèixer els efectes de la proteïna de patata fermentada sobre els garrins i el segon per conèixer el nivell necessari d'incorporació a les dietes per substituir al plasma porcí. Es van usar 200 garrins en el primer estudi distribuint homogèniament segons el seu pes i edat al deslletament i el seu sexe. Es van distribuir en 5 grups de tractament on un grup va ser el control negatiu sense plasma ni proteïna de patata fermentada, un grup com a control positiu amb plasma en la dieta i 3 dosificacions creixents de proteïna de patata. En el segon estudi es van usar 1036 garrins distribuïts homogèniament segons el seu pes i edat al deslletament i el seu sexe. Es van distribuir en 6 grups de tractament on un grup va ser el control negatiu sense plasma ni proteïna de patata fermentada, un grup com a control positiu amb plasma en la dieta i 4 grups amb quantitats creixents de proteïna de patata fermentada. Els garrins alimentats amb plasma en el primer estudi van tenir el dia 4 del mateix un nivell major d'IGF-I que la resta sent els garrins que van ser alimentats amb la dosi inferior de proteïna de patata fermentada els que van tenir el nivell d'IGF-I inferior tenint la resta de grups un nivell intermedi d'IGF-I. Els garrins que més pinso consumir van ser els garrins que van consumir el menor nivell de proteïna de patata i els que menys els del grup control negatiu. Aquestes diferències de consum no es van veure reflectides en un major creixement diari ni en una millor conversió alimentària al final de l'estudi. Els garrins que van consumir proteïna de patata van tenir més pes i guany mitjà diari que els animals del control negatiu al final del segon estudi. Pel que fa al consum, els animals amb les 3 dosis més baixes de proteïna de patata van tenir major consum que la resta tenint una millor conversió alimentària dels garrins que van consumir bé proteïna de patata o plasma que els garrins del control negatiu. Els resultats de la present tesi demostren que el subministrament d'un suplement alimentari derivat de la fermentació de la proteïna de patata i) no millora la productivitat de les truges en el subsegüent part, ii) no millora la mortalitat dels garrins durant la lactació ni tampoc el seu pes a deslletament i iii) pot reemplaçar al plasma animal en les dietes de garrins deslletats. El nivell d'IGF-I no es veu modificat en cap estudi al subministrar la proteïna de patata fermentada per la qual cosa la manera d'acció d'aquest producte ha de ser investigat amb estudis futurs.
The objectives of this thesis were the study and review of the current knowledge about the metabolism and actions of IGF-I in pig production. The thesis also studied the effects that an additive coming from the fermentation of the potato protein can have on the IGF-I levels in the different pig production phases and if these modifications have some practical consequence in the pig production. In the lactating sows study, the objective was to assess if the introduction of the fermented protein potato in the diet of the sows 5 days before and 5 days after weaning, with or without glucose, had some effect on the non-productive days between weaning and mating, the fertility and the number of piglets total born in the subsequent litter, and if these productive parameters were in relation with plasma IGF-I levels. It was chosen a high productive sow farm with a high health status because it was considered the best option to assess the effects of the fermented protein potato over the studied parameters. 183 sows coming from 3 consecutive weaned batches sows were distributed in 4 treatment groups taking into account the parity, the number of piglets weaned in the former litter and the number of piglets born in the current litter. The dietary treatments were arranged as a 2x2 complete factorial design with the factors being the addition or not of fermented protein potato and with or without glucose. The treatment started 5 days before weaning and ends 5 days after weaning. There were recorded all the production parameters to get the targets and blood samples were obtained from a subgroup of sows to analyze IGF-I level. No statistical differences were found in IGF-I levels at the end of the treatment nor in the productive parameters recorded. An outcome not considered in the design of the study was that nursing sows had higher IGF-I levels. This finding confirms that IGF-I level depends on the nutritional and metabolic status. Sows that were nursing an extra litter (small piglets) in the current lactation had lower metabolic expense that normal sows during the nursing time and there could recover their metabolic status. In spite of, there were not found productive differences in the next parity. In the study with milking piglets the objectives were to assess if the oral administration of the fermented potato protein in piglets during the first 12 h of live had some effects on the plasma levels of IGF-I, the pre weaning mortality and the average daily gain from birth to wean. This study was carried out in a sow farm with the country average production, with a standard health status. 542 piglets from 3 consecutive batches were used. Piglets were classified into two groups depending on their weight at birth because it was considered that weight at birth could influence the results. The cut-off weight was 1.2 kg. The treatments were: a single oral dose of fermented protein potato, a split half dose in 12 h interval of fermented protein potato, and a group of piglets that received glycerol as positive control group. One group of piglets with no treatment was considered negative control group. No differences were found in any group neither of treatment nor within the weight groups. IGF-I levels were higher in heavier piglets at 7 day of study but not at the end. In the study with weaned piglets the objectives were to assess if the introduction in the diet of the fermented potato protein in weaned piglets at different ratios could substitute the use of animal plasma and if this modification was linked with the plasma level of IGF-I. This study was carried out in a nursery using piglets from the sow farm used in the milking piglets study. There were conducted 2 consecutive experiments. The first of them was carried out to assess the effects of the fermented protein potato on the productive parameters and the second to assess the level to substitute animal plasma. In the first experiment, 200 piglets were distributed taking into account their age, sex and weight at weaning in 5 experimental groups. One group was considered as negative control group with neither fermented protein potato nor animal plasma, one group was the positive control group with animal plasma and 3 other groups with different levels of fermented protein potato. In the second experiment, 1036 piglets were distributed taking into account their age, sex and weight at weaning in 6 experimental groups. One group was the negative control group without animal plasma or fermented protein potato, one group as positive control group with animal plasma and 4 groups with increasing ratios of fermented protein potato. IGF-I levels at day 4 of the first study were higher in piglets fed with animal plasma being the lowest IGF-I level for the piglets fed the lower ratio of fermented protein potato. The rest of the groups had intermediate IGF-I levels. The highest daily feed intake was achieved by the piglets fed with the lowest ratio of fermented protein potato. This high daily feed intake was not achieving a high daily gain or a better feed conversion ratio at the end of the study. Piglets fed with fermented protein potato were heavier and growth faster than piglets in the negative control group at the end of the second study. The highest daily feed intake was achieved by the piglets fed the 3 lower doses of fermented protein potato. Feed conversion ratio was improved in piglets fed either fermented protein potato or animal plasma than piglets in the negative control group. The results of the studies of this thesis show that feeding a fermented protein potato i) do not improve the productivity of the sows in the subsequent parity, ii) do not improve pre weaning piglet mortality nor their weaning weight, iii) can substitute animal plasma in the post weaning diets. The IGF-I levels were not modified in any study when fermented potato was administered orally either to weaned sows, pre weaning piglets or weaned piglets. The mode of action of fermented protein potato should be researched in future experiments.
Khoshal, Abdullah Khan. "Le déoxynivalénol et des mycotoxines émergentes dans l'alimentation du porc : co-occurrence et toxicité combinée sur cellules intestinales et explants hépatiques." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30017.
Повний текст джерелаMycotoxins are toxic secondary metabolites, produced by several filamentous fungi. Depending on their toxicity and occurrence, some of them, including deoxynivalenol (DON), one of the most common toxin in food and feed, have been regulated in the European Union. Other secondary metabolites, which neither routinely determined nor regulated, are called emerging mycotoxins because they have been recently discovered or poorly investigated. Food and feed can be naturally contaminated by several mycotoxins and concern about the hazard of exposure to mycotoxin mixtures is increasing. Among farm animals, pig is one of the most sensitive farm animal to mycotoxins and it can be exposed, through its rich cereal diet, to high concentrations of mycotoxins. In total, 524 finished pig feeds samples from worldwide were analyzed for more than 800 metabolites using, LC- MS/MS (liquid chromatography tandem-mass spectrometry) method. Eighty-eight percent of the samples were co-contaminated with DON and other regulated and emerging mycotoxins. The toxicity of DON and the 10 most common emerging mycotoxins was analyzed on the viability of porcine intestinal epithelial cells (IPEC-1) over a 48 h period. Among the emerging mycotoxins, 3 of them (brevianamide F, cyclo-(L-Pro-L-Tyr), and tryptophol) did not alter cells viability. The other mycotoxins were ranked in the following order of toxicity: apicidin> enniatin A1> DON> beauvericin> enniatin B> enniatin B1> emodin> aurofusarin. The combined toxicity of DON and the 10 emerging mycotoxins was assessed based on their actual ratios found in pig feed. We observed that, despite the very high frequency of co- contamination, there was a poor correlation between the concentrations of DON and emerging mycotoxins. Thus, we assessed the toxic effects of three mixtures corresponding to situations to which animals may be exposed. Ratio #1 was calculated using the P25 (1st quartile) concentration of the emerging mycotoxin and P75 (3rd quartile) concentration of DON. Ratio #2 was calculated using the median (2nd quartile) concentration of DON and each emerging mycotoxin. Ratio #3 was the reverse scenario of ratio #1. Cytotoxicity analyses showed that, in most of the mixtures, the combined toxicity was similar to the one of DON alone. These results demonstrated that, when these emerging mycotoxins are present with DON, in terms of pig health, it does not exacerbate the problem of the toxicity of DON. In addition to intestine, liver is the main site of detoxification for xenobiotics, including mycotoxins and represents a target organ for food contaminants. Hence, we developed a new tool the Precision Cut Liver Slices (PCLs) an ex vivo explants of liver with a well-defined thickness. This tool was used to assess the toxicity of DON (3 and 10 µM) at different incubation times (0 to 20 h), by studying gene expression, ATP and total protein contents. The incubation medium was used to assess the quality of PCLS by measuring liver damage markers (alkaline phosphatase, lactate dehydrogenase, alanine transaminase, aspartate transaminase and total proteins). We showed that these markers were not affected by either incubation time or treatment. PCLS treated with 10 µM DON for 4 h or more, showed an alteration in the expression of certain genes. These preliminary experiments demonstrated that PCLS represent a promising model for assessing the hepatic toxicity of mycotoxins or other food contaminants
Mouré, Anne. "Stratégies pour remédier à l'hypoxie dans le pancréas bio-artificiel." Thesis, Nantes, Ecole nationale vétérinaire, 2019. http://www.theses.fr/2019ONIR125F.
Повний текст джерелаType 1 diabetes is a chronic disease caused by the autoimmune destruction of beta cells within the pancreatic islets. The transplantation of pancreatic alloislets has already entered the clinics for this disorder. However, the shortage of human donor organs and the need for lifelong immunosuppressive treatments to prevent graft rejection strongly limit the extension of this approach to a larger patient population. The development of a bioartificial pancreas (BAP), based on the encapsulation of allo-or xenogeneic islets in an immunoprotective membrane, is gathering interest to overcome the main hurdles of islet allotransplantation. However, maintaining the 02 supply after transplantation and before graft vascularisation remains the major challenge to ensure the BAP therapeutic efficacy over extended periods of lime. lndeed, hypoxia induces islet cell dysfunction and finally cell death. In this context, this work aims to develop and evaluate strategies to overcome the hypoxia-induced damages in the BAP. First, neonate pig islets were evaluated in the BAP as a promising islet source exhibiting resistance to hypoxic damages. Then, an efficient oxygenation strategy for the BAP was developed by combining the 02 carrier HEMOXCell (marine haemoglobin, Hemarina) with an 02 generator composed of silicone-encapsulated calcium peroxide. Finally, a planar device based on this oxygenation strategy was designed and optimised to maintain the 02 balance in the BAP supporting a high islet density in a hypoxic environment. This work should allow to improve the BAP therapeutic efficacy and to scale a more realistic device for human clinical applications by maintaining the 02 balance
MONTEIRO, CANDICE LOURENCO. "NUMERICAL SIMULATION OF PIG MOTION THROUGH PIPELINES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 1998. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=19370@1.
Повний текст джерелаTubulações industriais são a maneira mais segura, rápida e econômica de se transportar diferentes produtos, principalmente aqueles relacionados com a industria do petróleo. Essas tubulações sempre envolvem altos investimentos financeiros sendo, portanto, fundamental a garantia de um funcionamento contínuo, com o mínimo de interrupções. Para isso são usados Pigs. Pigs são dispositivos utilizados com muita frequência e com várias finalidades, tais como limpeza e desobstrução de tubulações, retirada de água, vedação de linhas, separação de diferentes produtos, remoção de condensado, inspeção e em testes hidrostáticos. O modelo aqui desenvolvido utiliza as equações unidimensionais da conservação de massa e da quantidade de movimento linear, para simular o movimento transiente do fluido. A equação de conservação de quantidade de movimento para o Pig é resolvida simultaneamente. Uma equação auxiliar para prever a vazão de fluido através do by-pass é proposta e acoplada ao sistema. Vários casos típicos são estudados, obtendo-se excelentes resultados.
Industrial pipelines are the safest, fastes and the most economical way to transport a large range of products, mostly those related to the oil industry. Pipeline systems are usually associated with huge financial investiments, being of fundamental importance to sustain their continuous operation, and maintainning them, reducing the number of interruptions or accidents at a minimum level. To accomplish that, pigs are used. Pigs are devices frequently used for many different purposes, a few of them are clemaming and dewatering a pipeline, sealing of a papeline, transport of different products, inspection and hydraulic tests all of them being accomplished without the interruption of the production lines. The developed model uses the unidimensional conservation equation of mass and linear momentum to simulate the transient movement of the fluid. The conservation of linear momentum of the Pig is also solved, Auxiliary equation to predict the by-pass flow is also incorporated into the system. several special cases are studied with very good results.
Mayhew, Emily Rose. "The Guinea Pig Club : reconstructing the hero in World War Two." Thesis, Imperial College London, 2003. http://hdl.handle.net/10044/1/8096.
Повний текст джерелаMuraski, John A. "The cardioprotective effects of Pim-1 kinase." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3310011.
Повний текст джерелаTitle from first page of PDF file (viewed September 4, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 90-103).
TOLMASQUIM, SUELI TIOMNO. "DESIGN AND CONTROL OF PIG OPERATIONS THROUGH PIPELINES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2004. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5754@1.
Повний текст джерелаNa indústria do petróleo, a passagem de pigs em dutos tem sido largamente aplicada com diferentes propósitos: limpeza do tubo, inspeção, remoção de líquido e separação de produtos, entre outros. A eficiência e segurança de uma operação com pig demandam que diversos parâmetros operacionais, tais como pressões máximas e mínimas no duto e velocidade de movimentação do pig, sejam bem avaliados durante a etapa de planejamento e mantidos dentro de determinados limites durante o acompanhamento da operação. Tendo como objetivo a obtenção de uma ferramenta eficiente para ajudar no controle e projeto das operações de passagem de pigs, desenvolveu-se um código numérico baseado no método de diferenças finitas para a simulação de escoamentos transientes de dois fluidos, podendo estes ser líquido-líquido, gás-gás ou líquido-gás. Módulos para controle automático das variáveis do processo foram incluídos, visando à previsão do escoamento mediante diferentes estratégias para alcançar uma operação eficiente. Problemas teste foram realizados, validando a metodologia. Por fim, os resultados obtidos com o simulador são comparados com um caso real de esvaziamento de um trecho do oleoduto OSPAR, pertencente à Petrobras, com 30`` de diâmetro e extensão de 60 km.
In the oil industry, pigging operations in pipelines have been largely applied for different purposes: pipe cleaning, inspection, liquid removal and product separation, among others. Pigging operations to be efficient and safe require a number of operational parameters, such as maximum and minimum pressures in the pipeline and pig velocity, to be well evaluated during planning stage and maintained within stipulated limits while the operation accomplishment. With the objective of providing an efficient tool to assist in the controlling and designing of pig operations through pipelines, a numerical code based on a finite difference scheme for a two-fluid transient flow simulation was developed. The model accounts for liquid-liquid, gas-gas and liquid-gas products in the pipeline. Automatic control modules for some process variables were included to permit the flow prediction by means of different strategies to reach an efficient operation. Test problems were performed to validate the methodology. At last, simulation results were compared with an actual liquid displacement operation at a 60 km segment of the 30`` diameter OSPAR pipeline, owned by Petrobras.
Dziubajlo, Maria. "Factors affecting the composition and physical properties of pig adipose tissue triacylglycerols." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46754.
Повний текст джерелаSALCEDO, THIAGO. "ANALYSIS OF THE SENSING SYSTEM OF A FEELER PIG." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2009. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=15689@1.
Повний текст джерелаEste trabalho apresenta a análise do sistema de medição utilizado pelo pig instrumentado tipo palito usado para detecção e dimensionamento de perda de espessura em dutos provocada por corrosão interna. A aplicação de testes experimentais de vibração, perfilagem geométrica e análise por elementos finitos têm objetivo de avaliar o sistema de medição dos sensores palito do Pig Palito, assim como mostrar os resultados obtidos com esta nova tecnologia de dimensionamento de micro geometria. Os dutos submarinos (offshore) empregam tradicionalmente as mesmas tecnologias de inspeção usadas em dutos terrestres (onshore) e uma dessas tecnologias é o pig instrumentado. No entanto, é encontrada uma vasta quantidade de dutos offshore com diferentes tipos de obstáculos que inviabilizam o uso dos pigs instrumentados convencionais, como os Pigs Magnéticos M.F.L. (Magnetic Flux Leakage) e Ultrassônicos. Os fatores relevantes que dificultam a inspeção, especialmente em dutos offshore, são os multi-diâmetros, raios de curvatura acentuados, equipamentos instalados ao longo do duto, alta espessura de parede do duto, escoamento multifásico, etc. Atualmente, o uso de Pigs Ultrassônicos e Magnéticos são as técnica disponíveis no mercado para inspeção da corrosão. Contudo, esses pigs possuem suas próprias limitações. Dentro deste contexto, foi desenvolvido um novo pig instrumentado, chamado de Pig Palito, para detecção e dimensionamento de perda de espessura em dutos com corrosão interna. Esta ferramenta foi desenvolvida para superar diversas limitações que outros pigs instrumentados convencionais têm durante a inspeção. Os resultados obtidos pela instrumentação do sensor palito na análise experimental indicam que a vibração dos sensores pode interferir na medição de micro geometria gerando erros de interpretação. A possibilidade de detecção, minimização e/ou eliminação desta possível deficiência do sensor palito são factíveis e abordadas na presente dissertação. Os bons resultados das inspeções de campo com os Pigs Palito comprovam o sucesso e viabilidade técnica no emprego desta tecnologia.
This work presents the analysis and study of the technology used by the instrumented pig called Feeler Pig, used for detection and measurement of loss of wall thickness in pipelines due to internal corrosion. Those study´s objective are the evaluation of dynamic measurement of Feeler Pig´s sensors, through the application of experimental vibration tests, geometric evaluation`s tests and finite elements analysis, so that are showed the results rewarded by this new micro geometric measurement technique. Submarine pipelines (offshore pipelines) inspection traditionally employs the same technologies used for onshore pipelines and one of such technologies is the instrumented pig. However, it is very common to find offshore pipelines with many kinds of obstacles that may prevent the use of conventional instrumented pigs, like MFL (Magnetic Flux Leakage) pigs and ultrasonic ones. The relevant factors that make the inspection difficult, particularly in offshore pipelines, are the different diameters along the pipeline, small radius bends, equipments installed in the pipeline (such as manifolds and valves), increased wall thickness, multi-phase fluids, etc. Currently available techniques in the market to inspect these pipelines are ultrasonic and magnetic pigs, which, nevertheless, have their own limitations. Focusing on this context, a new tool was developed to detect and measure the loss of wall thickness in pipelines due to internal corrosion. This tool, called Feeler Pig, was designed to be able to overcome some of the limitations of conventional inspection pigs. The results achieved by instrumentation of the feeler type sensor`s body, experimental analysis tests, proved that vibration modes of the sensor interferes in the measurement of micro geometric. The possibility of detection, mitigation and / or elimination of the deficiencies of sensor`s issues are viable and addressed in this work. These, coupled with the excellent results of Feeler Pigs field inspections prove the technical feasibility and success in using this technology.
Belvisi, Maria Gabriela. "Excitatory non-adrenergic non-cholinergic nerves and their modulation in guinea-pig airways." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/47771.
Повний текст джерелаJohnson, William Benjamin. "Phosphodiesterase function and activity in isolated cardiomyocytes from rat, guinea pig and human heart." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4414.
Повний текст джерелаPierron, Alix. "Toxicity of three biological derivatives of deoxynivalenol : deepoxy-deoxynivalenol, 3-epi-deoxynivalenol and deoxynivalenol-3-glucoside on pigs." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30096/document.
Повний текст джерелаThe Fusarium sp. mycotoxin deoxynivalenol (DON) is one of the most frequently widespread mycotoxin worldwide. Due to its high structural stability, the elimination of DON, once present in cereals or feed materials, becomes difficult. Thereby, it is present in many cereals and final feed products, inducing several toxic effects on human and animals, and causing big economic losses. New strategies of to fight against mycotoxins were developed, as biological transformation, either by the use of bacteria or plants. Indeed, some microorganisms are able to transform DON in new products, by enzymatic reaction, forming the deepoxy-deoxynivalenol (DOM-1) and the 3-epi-deoxynivalenol (3-epi-DON). Moreover, some plants naturally own the capacity to glycosylate DON in the aim to detoxify it, forming the deoxynivalenol-3-ß-D-glucoside (D3G). The aim of this thesis was to assess the toxicity of these DON derivatives, on the intestine and immune response, using several approaches such as in silico, in vitro, ex vivo and in vivo models. On the human intestinal Caco-2 cell line, DOM-1, 3-epi-DON and D3G were not cytotoxic; they did not alter its viability and barrier function, as measured by the trans epithelial electrical resistance. The expression profile of DOM-1, 3-epi-DON and D3G-treated jejunal explants was similar to that of controls and these explants did not show any histomorphology alteration. On the other hand, the treatment of intestinal explants with DON, induced morphological lesions and upregulated the expression of proinflammatory cytokines. The impact of these three derivatives was also studied on intestinal explants with a pan-genomic transcriptomic analysis. Results show that the derivatives of DON did not induce any change on the gene expression in comparison to the control-treated explants. In contrary, DON-treated explants differentially expressed 747 probes, representing 323 genes involved in immune and inflammatory responses, oxidative stress, cell death, molecular transport and mitochondrial function. In silico analysis revealed that D3G, opposing to DON, was unable to bind to the A site of the ribosome, which is the main target for DON toxicity. Both DOM-1 and 3-epi-DON were able to fit into the pockets of the A site of the ribosome but only by forming two hydrogen bonds, while in this position, DON forms three hydrogen bonds. Moreover, the three derivatives do not elicit a ribotoxic stress, MAPKinase activation, and inflammatory response. Then, an in vivo study was carried out to assess the toxicity of DOM-1 on pig (feed forced during 21 days at 0.14 mg/Kg BW). The results showed that DOM-1 does not have as much toxic effects as DON on zootechnical parameters (no emesis induced, no decrease of food consumption or weight loss observed), on intestine and liver (no tissues damages), or on the immune response (no inflammatory response induced). Our data demonstrate that bacterial de-epoxidation or epimerization of deepoxy-DON modified its interaction with the ribosome, leading to an absence of MAPKinase activation and toxicity; and that the glycosylation of DON suppresses its ability to bind to the ribosome and decreases its intestinal toxicity. The mycotoxin deoxynivalenol (DON) remains an important challenge in many regions in the world. Thus, these biological detoxifications of DON seem to represent a new promising approach helping manage the problem of its contamination
Bachmann, Malte. "Funktion der Pim-1-Kinase in der Zellzyklus-Progression." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968734480.
Повний текст джерелаOkazaki, T. "The removal of copper and tin from molten pig iron and steel using sulphide slags." Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/37809.
Повний текст джерелаLin, Chih Che. "The role of donor versus recipient tissue factor in coagulopathy during pig-to-primate xenotransplantation." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5620.
Повний текст джерелаDunaiski, Vera. "Effects of IGF-1 or LR3IGF-1 infusion on components of the GH/IGF-1 axis in pigs /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phd897.pdf.
Повний текст джерелаKuo, Han-Pin. "Goblet cell secretion in guinea pig airways : neural control, response to cigarette smoke and pharmacological modulation." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46877.
Повний текст джерелаBhuller, Ravneet Kaur. "Comparative genome analyses to understand the population biology and virulence of the pig pathogen Actinobacillus pleuropneumoniae." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/59100.
Повний текст джерелаAndina, Nicola. "The role of Bim and Pim-1 in granulocyte survival /." Bern : [s.n.], 2009. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Повний текст джерелаLIMEIRA, FABIO MACHADO. "MODELING AND SIMULATION OF PIG DISPLACEMENT IN PIPELINES WITH BYPASS CONTROL VALVE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2017. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30917@1.
Повний текст джерелаCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
PROGRAMA DE EXCELENCIA ACADEMICA
A utilização de PIG em oleodutos e gasodutos tem uma grande importância para a manutenção da integridade estrutural de tubulações, e pode ser utilizado para inspeção, limpeza e separação de interface. Neste contexto é importante que a passagem de PIG ocorra de modo controlado causando o menor impacto possível à operação, respeitando os limites operacionais da tubulação e dentro dos limites de velocidade de deslocamento do PIG. Caso o PIG possua uma velocidade baixa, ele pode ficar preso à tubulação, podendo ser difícil soltá-lo. Por outro lado, caso a velocidade seja elevada o PIG pode danificar a tubulação em função dos impactos gerados. Com o objetivo de atender os requisitos referente a velocidade recomendável de deslocamento do PIG referente aos limites operacionais existentes e não danificá-lo, foi desenvolvido um simulador termo hidráulico de deslocamento de PIGs. O simulador prevê escoamentos transientes isotérmico ou térmico acoplado ao deslocamento do PIG. Para controlar a velocidade do PIG, uma válvula de controle foi instalada no corpo do próprio PIG. Sua velocidade de deslocamento é função da abertura do furo de bypass, ou seja, quanto maior a velocidade de escoamento na tubulação, maior a abertura e maior o fluxo através do PIG para manter a velocidade controlada. As equações de conservação de massa, quantidade de movimento e energia, acopladas com um balanço de forças no PIG, foram discretizadas pelo método das diferenças finitas e resolvidas de forma acoplada. Para o controle da velocidade optou-se pelo método de controle PID. Investiga-se o deslocamento do PIG tanto para escoamento de líquido quanto de gás, considerando ou não a perda de calor para o ambiente. Diversos casos são apresentados demonstrando a eficácia do método de controle modelado.
The use of PIG in oil and gas pipelines has great important to maintain the structural integrity of pipelines, and it can be used for inspection, cleaning and interface separation. In this context, it is important that the PIG displacement happen in a controlled way causing the lowest possible impact to the operation, respecting the operating limits of the pipe and within the limits of the PIG s speed of displacement. If the PIG has a low speed, it can be trapped in the tubing and it can be difficult to release it. On the other hand, if the speed is high the PIG can damage the tubing in function of the generated impacts. In order to respect the requirements for the recommended PIG velocity displacement, and operational pipelines limits requirements, a thermo hydraulic PIG simulator was developed. The simulator predicts isothermal or thermal transient flow coupled with the PIG displacement. To control the PIG velocity, a control valve is installed in the body of the PIG. The PIG speed is as a function of the bypass aperture inside the PIG s body, ie, the greater the flow velocity in the pipe, the greater is the opening and the greater the flow through the PIG. The conservation equations of mass, momentum and energy coupled with force balance at the PIG were discretized by the finite difference method, and solved in coupled manner. A PID control method was employed to control the PIG velocity. It is investigated the displacement of PIG in both liquid and gas flow, considering or not the loss of heat for the environment. Several cases are presented demonstrating the effectiveness of the control method modeled.
Hopwood, Alexandra Margaret. "An investigation into the antiadrenergic effect of adenosine on the ventricular myocardium of guinea-pig and rabbit." Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/38038.
Повний текст джерелаYang, Kai-Chiang. "Low-adhesive Ethylene Vinyl Alcohol-based Packaging to Xenogeneic Islets Encapsulation for Type 1 Diabetes Treatment." Kyoto University, 2018. http://hdl.handle.net/2433/235062.
Повний текст джерелаDe, Guise Chantal. "Regulation of Pit-1 gene expression by activin in pituitary cells." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111923.
Повний текст джерелаIglesias, J. Gerardo. "Studies on the vertical transmission of Suid herpesvirus-1 in pigs." Thesis, University of Surrey, 1985. http://epubs.surrey.ac.uk/847553/.
Повний текст джерелаZiegelbäck, Martin, and Gregor Kastner. "Arbitrage hedging in markets for the US lean hogs and the EU live pigs." Czech Academy of Agricultural Sciences, 2013. http://epub.wu.ac.at/4863/1/Ziegelbaeck_Kastner_2013_AE_Arbitrage%2Dhedging.pdf.
Повний текст джерелаSong, Jin H., Sathish K. R. Padi, Libia A. Luevano, Mark D. Minden, Daniel J. DeAngelo, Gary Hardiman, Lauren E. Ball, Noel A. Warfel, and Andrew S. Kraft. "Insulin receptor substrate 1 is a substrate of the Pim protein kinases." IMPACT JOURNALS LLC, 2016. http://hdl.handle.net/10150/614947.
Повний текст джерелаKim, Heesun. "PIE-1, SUMOylation, and Epigenetic Regulation of Germline Specification in Caenorhabditis elegans." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/986.
Повний текст джерелаWright, Elizabeth Joanne. "GLP-1 CellBead therapy for the prevention of left ventricular dysfunction in pigs." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/glp1-cellbead-therapy-for-the-prevention-of-left-ventricular-dysfunction-in-pigs(740704bb-46f1-44af-8eb2-22117a7efd05).html.
Повний текст джерелаSornson, Mark W. "Prophet of Pit-1 : the positional cloning of the murine ames dwarf locus /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9835295.
Повний текст джерелаKinnon, Sharron. "Functional and molecular analysis of the myc co-operating genes bmi-1 and pim-1 in feline fibroblasts and lymphoma." Thesis, Glasgow Caledonian University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313172.
Повний текст джерелаSliman, Faten. "Conception, synthèse et évaluation biologique de nouveaux ligands hétérocycliques de la sérine-thréonine kinase Pim-1." Paris 11, 2010. http://www.theses.fr/2010PA114820.
Повний текст джерелаThis thesis describes the design and the synthesis of a new family of inhibitors of the serine/threonine kinase Pim-1 which as been recognized as a promising target for cancer drug therapy. These molecules, whose main pharmacophore is the 8-hydroxy-7-quinoléinecarboxylic acid moiety, selectively inhibit the kinase Pim-1. Relying on molecular modeling studies performed using the software GOLD V, we have proposed a binding mode of these molecules within the catalytic site of the kinase Pim-1 and we have suggested new potential inhibitors. The most important ones display an aryl or a heteroaryl ring at the C-5 carbon of the quinoline nucleus. Their synthesis was achieved using a sequence involving a Suzuki cross-coupling reaction using organotrifluoroborate as key step. O-debenzylation at C-8 by transfer hydrogenation under microwave heating has completed the synthesis. The new inhibitors have been tested on the kinase Pim-1 and the structure-activity relationships are discussed based on docking studies
Weatherly, Kristy Lynn Jr. "Regulation of Pituitary Genes by the Transcription Factor, Pit-1, in the Domestic Turkey (A Turkey is NOT a Feathered Rat)." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/9770.
Повний текст джерелаMaster of Science
Althumayri, Khalid Abdulmohsen M. "Polymers of intrinsic microporosity and incorporation of graphene into PIM-1 for gas separation." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/polymers-of-intrinsic-microporosity-and-incorporation-of-graphene-into-pim1-for-gasseparation(4e8909e1-4c5d-4ba2-b8a3-276295b3d5c4).html.
Повний текст джерелаHolyfield, Leighton. "Materials based on the polymer of intrinsic microporosity PIM-1 for hydrogen storage applications." Thesis, University of Bath, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760988.
Повний текст джерелаLaghari, Gul Mohammad. "Preparation and properties of polybenzodioxane PIM-1 and its copolymers with poly(ethylene glycol)." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/preparation-and-properties-of-polybenzodioxane-pim1-and-its-copolymers-with-polyethylene-glycol(1b728ac9-9362-415d-ae6a-61dd3ffde884).html.
Повний текст джерелаKroegel, Claus. "Molecular mechanisms of stimulus-response coupling in human and guinea pig eosinophils : transduction pathways utilized by platelet activating factor and their relationship to cellular effector functions." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46876.
Повний текст джерела