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Добірка наукової літератури з теми "PHYTOCHEMICAL CANDIDATES"

Автор: Grafiati

Опубліковано: 9 листопада 2023

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Статті в журналах з теми "PHYTOCHEMICAL CANDIDATES"

Eskundari, Ratna Dewi, Tri Wiharti, Nur Rokhimah Hanik, Fety Fatimah, Umi Salamah, and Antik Murwani. "Phytochemical test of several eco-handsanitizer candidates." Jurnal Biologi Tropis 22, no. 1 (January 28, 2022): 297–303. http://dx.doi.org/10.29303/jbt.v22i1.3258.

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Ecoenzymes are natural ingredients formed from the fermentation of fruit and or vegetable residues that have many benefits. One of the benefits of ecoenzymes is that they can be used as eco-handsanitizers; which can be used as a candidate for handsanitizer for those who are allergic to alcohol-based handsanitizer. This study aims to determine the pH, antibacterial, antiviral, and antifungal content of the candidate eco-handsanitizer solution through alkaloid, flavonoid, and saponin test, also fungal-inhibition test. The candidate eco-handsanitizer solution was made from an ecoenzyme solution derived from fruit or vegetable residue and added with aloe vera gel and vitamin C or E. The results showed that eco-handsanitizer candidate solution derived from ecoenzyme solution with a dilution of 1:500 or 1:4 and added with aloe vera and vitamin E had a pH that tends to be acidic after 5 weeks of manufacture. The candidate eco-handsanitizer solution contained alkaloid compounds up to 2nd week for 1:500 dilution or up to 5th week for 1:4. Fungal test also showed positive results of one of the treatments in inhibiting fungal growth until the 11th day. These results were expected to be used as guidelines for further research, such as quantitative and qualitative tests for more sensitive alkaloids, for example using GC-MS.ÃÂ

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Gu, Shaobin, Ying Wu, and Jianbo Yang. "Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals." PeerJ 4 (May 11, 2016): e1983. http://dx.doi.org/10.7717/peerj.1983.

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As a well known anti-neoplastic drug, the cytogenotoxicity of methotrexate (MTX) has received more attention in recent years. To develop a new cytoprotector to reduce the risk of second cancers caused by methotrexate, an umu test combined with a micronucleus assay was employed to estimate the cytoprotective effects of ten kinds of bioactive phytochemicals and their combinations. The results showed that allicin, proanthocyanidins, polyphenols, eleutherosides and isoflavones had higher antimutagenic activities than other phytochemicals. At the highest dose tested, the MTX genetoxicity was suppressed by 34.03%∼67.12%. Of all the bioactive phytochemical combinations, the combination of grape seed proanthocyanidins and eleutherosides from Siberian ginseng as well as green tea polyphenols and eleutherosides exhibited stronger antimutagenic effects; the inhibition rate of methotrexate-induced genotoxicity separately reached 74.7 ± 6.5% and 71.8 ± 4.7%. Pretreatment of Kunming mice with phytochemical combinations revealed an obvious reduction in micronucleus and sperm abnormality rates following exposure to MTX (p< 0.01). Moreover, significant increases in thymus and spleen indices were observed in cytoprotector candidates in treated groups. The results indicated that bioactive phytochemicals combinations had the potential to be used as new cytoprotectors.

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Abdullahi, Sharif Alhassan, Ngah Zasmy Unyah, Noshariza Nordin, Rusliza Basir, Wana Mohammed Nasir, Ashraf Ahmad Alapid, Yahaya Hassan, Tijjani Mustapha, and Roslaini Abd Majid. "Phytochemicals and Potential Therapeutic Targets on Toxoplasma gondii Parasite." Mini-Reviews in Medicinal Chemistry 20, no. 9 (May 27, 2020): 739–53. http://dx.doi.org/10.2174/1389557519666191029105736.

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Identification of drug target in protozoan T. gondii is an important step in the development of chemotherapeutic agents. Likewise, exploring phytochemical compounds effective against the parasite can lead to the development of new drug agent that can be useful for prophylaxis and treatment of toxoplasmosis. In this review, we searched for the relevant literature on the herbs that were tested against T. gondii either in vitro or in vivo, as well as different phytochemicals and their potential activities on T. gondii. Potential activities of major phytochemicals, such as alkaloid, flavonoid, terpenoids and tannins on various target sites on T. gondii as well as other related parasites was discussed. It is believed that the phytochemicals from natural sources are potential drug candidates for the treatment of toxoplasmosis with little or no toxicity to humans.

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H, Shahzad. "Antioxidants from Bauhinia and Future Research Gap." Annals of Experimental and Molecular Biology 5, no. 1 (February 27, 2023): 1–8. http://dx.doi.org/10.23880/aemb-16000118.

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Flower buds of Bauhinia are utilized as a human means of nourishment, and the stem and leaves serve as feed for livestock across the world. This chapter highlights the medicinal importance of various parts of Bauhinia plants. Bauhinia plants’ edible regions are an excellent source of phytochemicals that have notable potential as antioxidants. Various phytochemical compounds that include Saponins, glycosides (kaempferol-3-glucoside), cardiac glycosides, sterols (β-sitosterol), tannins, phenolics, alkaloids, terpenoids (Lupeol), quinones, flavanones and flavonoids reside in these plants. These plants exhibit powerful potential as antioxidants for lipid-reducing, metal-reducing, free radical scavenging activities and metal-chelating. These also demonstrate an encouraging impact on glutathione peroxidase activity, an antioxidant enzyme. Moreover, they inhibit tyrosinase activity. Moreover decreased the levels of different liver markers (ALT, AST and ALP), and antioxidant enzymes and shift them to normal levels. Among the several Bauhinia genus species that have been explored for their antioxidant potential and phytochemical constitution, Bauhinia variegata seeds, leaves and florets have superior antioxidant and phytochemical properties. Other Bauhinia genus species that are packed with antioxidants and phytochemicals include Bauhinia vahlii, Bauhinia strychnifolia Craib, Bauhinia rufescens, Bauhinia racemosa and Bauhinia purpurea. Moreover, many factors influence the anti-oxidant potential of medicinal plants but up to the study of the year 2023, only the impact of solvent on the Bauhinia species’ antioxidant potential has been studied, it is a necessity that upcoming research must focus on the research on remaining factors for maximum yield of antioxidants from this antioxidant-rich plant. The antioxidant capacity and phytochemical composition of Bauhinia plants render them the most suitable candidates for use in therapeutics and dietary supplements.

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Nathan, Bharathi, and Sudheer M. M. Mohammed. "An insight into anti-arthritic property of phytochemicals against Rheumatoid arthritis using molecular modelling and docking approach." Research Journal of Biotechnology 16, no. 12 (November 25, 2021): 185–95. http://dx.doi.org/10.25303/1612rjbt185195.

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Arthritis literally refers “joint inflammation”, it is a condition where one or more joints are inflamed. More than 100 different types of Arthritis were identified, most common types are rheumatoid arthritis and osteoarthritis. The present study mainly focuses on the development of the novel phytochemical inhibitors against rheumatoid arthritis and osteoarthritis using an integrative cheminformatics drug discovery platform. In this study, we identified potential 405 phytochemical drug candidates, screened against eight selected targets of rheumatoid arthritis and osteoarthritis using molecular docking tool AutoDock. Three phytochemicals Withanolide, Diosgenin and bamyrin exhibited promising binding towards multiple drug targets selected for this study. When comparing with the binding between reference drugs, withanolide showed highest activity against Interleukin-23, Matrix metalloproteinase-3 and Interleukin 8 with binding energies -11.6, -9.4 and -8.3 kcal/mol respectively. Diosgenin also exhibited best activity against three targets that were Interleukin-23, JNK alpha and MMP-3 with -11.3, -10.4, -9.5 kcal/mol binding energies respectively. This study may be important contributing factor to develop new therapeutic drugs for rheumatoid arthritis and osteoarthritis.

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Sameh, Salma, Eman Al-Sayed, Rola M. Labib, and Abdel Nasser Singab. "GenusSpondias: A Phytochemical and Pharmacological Review." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/5382904.

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It is believed that many degenerative diseases are due to oxidative stress. In view of the limited drugs available for treating degenerative diseases, natural products represent a promising therapeutic strategy in the search for new and effective candidates for treating degenerative diseases. This review focuses on the genusSpondiaswhich is widely used in traditional medicine for the treatment of many diseases.Spondiasis a genus of flowering plants belonging to the cashew family (Anacardiaceae). This genus comprises 18 species distributed across tropical regions in the world. A variety of bioactive phytochemical constituents were isolated from different plants belonging to the genusSpondias. Diverse pharmacological activities were reported for the genusSpondiasincluding cytotoxic, antioxidant, ulcer protective, hepatoprotective, anti-inflammatory, antiarthritic, and antidementia effects. These attributes indicate their potential to treat various degenerative diseases. The aim of this review is to draw attention to the unexplored potential of phytochemicals obtained fromSpondiasspecies, thereby contributing to the development of new therapeutic alternatives that may improve the health of people suffering from degenerative diseases and other health problems.

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Siregar, Yoga, Montesqrit, and Harnentis. "Potensi fitokimia daun belimbing wuluh (Averrhoa Bilimbi L.) dengan pengeringan berbeda sebagai kandidat antibiotik alami broiler." Agrivet : Jurnal Ilmu-Ilmu Pertanian dan Peternakan (Journal of Agricultural Sciences and Veteriner) 11, no. 1 (June 20, 2023): 37–44. http://dx.doi.org/10.31949/agrivet.v11i1.5746.

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This study aimed to determine the phytochemical potential of belimbing wuluh leaves (Averrhoa bilimbi L.) as natural antibiotic candidates for broilers. Belimbing wuluh leaves were processed by drying them in direct sunlight, indirect sunlight, and an oven at 60 °C. The obtained data were descriptively analyzed. The parameters measured were the phytochemical screening test and the Escherichia coli antibacterial test. The results of the phytochemical screening test for starfruit leaves, indirect sunlight drying method, direct sunlight method, and 60 °C oven drying, positively contained phenolic compounds, alkaloids, flavonoids, and steroids; however, the three drying methods did not contain triterpenoid compounds. The results of the activity test for the inhibition of starfruit leaf bacteria in the three drying methods showed positive inhibition of Escherichia coli bacteria, with the largest diameter of the inhibition zone produced in the 60 °C oven drying process. It can be concluded that drying starfruit leaves using an oven at 60℃ produces phenolic compounds, flavonoids, saponins, alkaloids, and steroids, can inhibit Escherichia coli bacteria with an inhibition zone diameter of 4.30 mm and starfruit leaves have the potential to be used as a candidate broiler natural antibiotics.

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Harish, M., C. V. Ranjith, and C. Sethulekshmy Nair. "Effectiveness of Quercetin and Its Derivatives Against SARS CoV2 -In silico Approach." Journal of Experimental Biology and Agricultural Sciences 10, no. 5 (October 31, 2022): 1003–15. http://dx.doi.org/10.18006/2022.10(5).1003.1015.

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The COVID-19 pandemic that erupted in November 2019 is continuing, with no effective antiviral agent to date. Synthetic antiviral agents have limitations such as a narrow range of therapeutic effectiveness of the activity, toxicity, and resistant viral strains and traditional antiviral medicines at large seem not to have these limitations. Here, some of the existing phytochemicals are cherry-picked for repurposing against the enzyme or protein targets of SARS CoV2, by the principles of structure-based drug design based on molecular docking studies. The most important drug targets of SARS CoV2 namely, Mpro protease (6LU7), RdRp polymerase (7BTF), and Spike glycoprotein of SARS CoV2(6VSB) were employed for docking analysis with chosen phytochemicals and binding affinity was calculated using PRODIGY software and docking sites determined using Chimera software. For docking studies, 160 phytochemicals were selected from a large pool of phytochemicals. Based on the binding affinity values, 61 phytoconstituents were selected for further in-silico screening which resulted in 15 phytochemicals, with higher binding affinity to spike glycoprotein of SARS CoV2. Moreover, Guaijaverin, Quercetin, Quercitrin, Quinic acid, and spiraeoside binds both to the spike glycoprotein of SARS Cov2 and the host receptor of human ACE2. Hence these compounds may serve as two-pronged drug candidates for SARS CoV2. In nutshell, we present a few phytochemical candidates with higher binding affinity to the Spike protein of SARS CoV2, which needs to be further optimized by in vitro studies to minimize the cytotoxicity and increase or retain the binding affinity, towards an effective antiviral drug against COVID 19.

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Christopher Busayo Olowosoke, Adebola Abosede Alaba, and Benjamin Babatunde Adegboyega. "Citrullus lanatus natural product library: A hoard of viable potential inhibitor candidates for diabetes mellitus type II therapeutic target enzymes." World Journal of Advanced Research and Reviews 15, no. 1 (July 30, 2022): 534–60. http://dx.doi.org/10.30574/wjarr.2022.15.1.0713.

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The ethnomedicinal function of several cucurbit species (cucumber, squash, melon, gourd, etc.) on diseases (i.e. diabetes, microbial infections, cancer, etc.), and as free radical scavengers have been reported. However, there remains infinitesimal record on citron watermelon broad use, which reflects the reason for wide oversight of underutilization, from lack of recognition for functional food crop development and commercialization. The objective of this study focus towards identifying the natural phytochemicals of C. lanatus on water melon molecules online database for insilico computational approach to screened for suitable antidiabetic lead, and construction of phylogenetic relatedness of target Type 2 Diabetes Mellitus proteins was conducted to predict reoccurrence of insilico analysis output with other homologous target proteins. The T2DM protein targets, phytochemical and standard inhibitory drugs are mined from different databases. Insilico docking analysis, and adme/toxicity profiling was virtually screened for the best fit. In additionally, phylogenetic relationship of the target proteins was aligned and construction with other homologous protein targets to predict the reoccurrence confidence of results on compounds. Seventeen phytochemicals out of the nineteen potential drug candidates substantially passed the profiling test. Also, homologous protein targets with > 90% bootstrap confidence are likely to produce a reoccurring insilico result. Thus, these phytochemicals fulfil all the enlisted criteria and it is suggestively determined to be suitable for the development of potent antidiabetic drugs. It is evident that phytochemicals from Citrullus lanatus produced satisfactory insilico output, and this reflect it to be a probable reservoir containing other potential therapeutic drug candidates for antidiabetic drug discovery and development. Additionally, derivatives can be developed for further effective screening result.

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Alshammari, Ahmed Mohajja. "Molecular dynamics simulation analysis of alpha-cobratoxin docked with phytochemical compounds." Bioinformation 18, no. 9 (September 30, 2022): 834–40. http://dx.doi.org/10.6026/97320630018834.

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It is of interest to document data on the molecular dynamics simulation analysis of alpha-cobratoxin docked with phytochemical compounds. This can be used as effective drug candidates against the snake and scorpion venom. It should be noted experimental verification is needed to further validate the current data.

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Більше джерел

Частини книг з теми "PHYTOCHEMICAL CANDIDATES"

Joy, Christy, and Marria C. Cyriac. "Phytochemicals as Potential Drug Candidates for SARS Cov-2: An RDRp Based In-Silico Drug Designing." In Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022), 58–69. Dordrecht: Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_7.

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AbstractThe global pandemic that the world is currently witnessing, COVID-19, even with vaccines available, the test positivity rate (TPR) tends to remain highly threatening. This research focuses on identifying phytochemicals, previously known for their broad-spectrum antiviral properties which can be potential drug candidates for theSARS-CoV-2. A total of 225 phytocompounds (downloaded from PubChem database) are docked against targetprotein (downloaded from PDB database) of SARS-CoV-2using the POAP pipeline. The target protein is the RDRp complex. They are screened according to their binding affinity values and the filtered phytochemicals are then subjected to various analyses including ADME properties (preADMET, swissADME), bioactivity score, and molecular properties (molinspiration), drug-likeness (preADMET), lipophilicity, water solubility, and pharmacokinetics (swissADME). The receptor-ligand interactions and the amino acid positions are obtained using Discovery Studio Visualiser. Molecular dynamic simulation studies are performed to reveal key receptor-drug interactions that must be formed to achieve tight drug binding and also to predict stability. Out of the 225, 10 phytochemicals showed the best scores and more probability of drug action. Compounds that showed promising drug action potential include oriciacridone, corilagin, cinchophyllamine, sophaline D, amentoflavone, cryptomisrine, ginkgetin, hypericin, pseudojervine, dieckol, hinokiflavone, robustaflavone, solamargine. The research herein provides new possibilities for in vitro and in vivo analyses of the proposed ligands to develop new drugs againstSARS-CoV-2.

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Acikalin Coskun, Kubra, Merve Tutar, Elif Cansu Abay, Nazlican Yurekli, Mervenur Al, and Yusuf Tutar. "Drugs and Drug Candidates for the Treatment of Lymphoma." In Lymphoma. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.103705.

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Cancer is the biggest health problem worldwide due to its high mortality rate. Lymphoma is defined as a group of malignant diseases that is caused by clonal proliferation of lymphocytes and is classified under two major groups: Hodgkin lymphoma and non-Hodgkin lymphoma. Genetic predisposition and some environmental factors constitute risk factors. Symptoms of the disease include unexplained fever, swelling of lymph glands, swollen abdomen, tiredness, loss of appetite, frequent infections, and weight loss. Positron emission tomography (PET) and computed tomography (CT) scans, along with MRI, are widely used for the diagnosis of lymphoma. Advanced blood and lymph node biopsy tests are used to evaluate treatment effect on blood cells and to confirm the diagnosis of lymphoma, respectively. Current treatment options include chemotherapy, radiotherapy, and bone marrow/stem cell transplantation. Development of new treatment options for cancer medications includes small molecules and monoclonal antibodies for immunotherapy. In addition, the discovery of new phytochemical agents used in complementary and alternative medicine adds perspective to the treatment of lymphoma.

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Maru, Harshnad, Kanchan Sharma, Saurav Kumar Mishra, and Georrge John J. "A Comprehensive Review of Ethnomedical Uses, Phytochemical Studies, and Properties of Holy Basil (Ocimum sanctum Linn.)." In Pharmacological Benefits of Natural Agents, 49–68. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-6737-4.ch004.

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Environment-derived products such as secondary metabolites from plants and animals also provide a humongous chemical space for potential candidates for drug discovery. It is a known fact that over 80% of the approved drugs have either been derived or are directly used in natural products. Ocimum sanctum L. or holy basil has been considered a majestic reservoir for medically potential phytochemicals and tremendous therapeutic applications. Basil was the most widely used medicinal plant in ancient civilizations in Africa, Central and South America, and Middle Eastern countries of Asia such as India, China, and Malaysia. Different parts of basil, such as leaves, stems, and roots, have shown various therapeutic activities. Phytochemicals derived from holy basil can be classified as terpenoid, flavonoid, phenolic acid, neolignan, phenylpropanoid, cerebroside, and coumarin. Bioinformatic and cheminformatic approaches such as target fishing and identification, pharmacophore-based modelling, and QSAR can be used to identify the potential targets.

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Oluwasegun Samson, Awotunde, Omogbadegun Olu Richard, and Mugambwa Joseph Yusuf. "Spirulina: A Living Library of Anticancer Phytochemicals." In Alternative Remedies and Natural Products for Cancer Therapy: An Integrative Approach, 199–209. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815124699123010013.

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Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. It is one of the major causes of human death, especially in developing countries. Alternative cancer treatments using medicinal plants are exploited because plants produce phytochemical compounds, which are secondary metabolites used for natural defence but could also be useful in inhibiting cancer growth. Medicinal plants also have limited side effects and toxicity as compared to conventional chemotherapy and irradiation treatments. Hence there is a need to develop novel drugs from other sources like plants, fungi, and algae. Spirulina is a blue-green alga with three species: Spirulina platensis, Spirulina fusiformis, and Spirulina maxima. Spirulina platensis and Spirulina maxima are consumable by humans in the form of dietary supplements, as they are enriched with important nutrients and a library of phytochemicals that can improve immunity and levels of blood lipids, lower blood sugar and blood pressure, and prevent oxidation. These activities of Spirulina phytochemicals make them a good candidate for anticancer therapy. Therefore, this chapter describes the botanical classification,

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Bicak, Bilge, and Serda Kecel Gunduz. "Computer-Aided Drug Design of Plant-Based Compounds." In Advances in Bioinformatics and Biomedical Engineering, 320–45. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-7337-5.ch013.

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Non-nutritive phytochemicals found in plants have a protective effect on health and contain various compounds for the prevention and treatment of various diseases. For these compounds, drug candidate studies of plant-based compounds can be carried out with various methods and techniques. Drug design and discovery is a very complex and expensive process, and nowadays, drug discovery studies are supported by computer-aided drug design. The important point in computer-based drug design is a good understanding of the molecular structure of drug candidates. Various theoretical and computational approaches are used in computer-aided drug design studies. These approaches, which are used to predict the structure and behavior of molecules, are of great importance in determining the structural properties of drug candidate molecules and understanding their interactions with various receptors. In this chapter, information will be given about the methods used in computer-aided drug design studies and studies carried out in the literature.

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Saylan, Demet, and Fatma Cebeci. "Isothiocyanates as Drug Candidates in Cancer Prevention and Treatment." In Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine, 22–60. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-9463-9.ch002.

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Cancer is the second most common cause of death worldwide. Many methods such as surgery, chemotherapy, radiation therapy, etc. are being used for treatment. Most patients have a combination treatment with chemotherapy along with surgery or radiotherapy or both. Chemotherapy kills cancer cells by preventing them from reproducing, growing, and spreading in the body. Recently, safer alternatives to chemotherapy have been discovered and developed, as most of the drugs used in cancer treatment have side effects and a serious impact on patient comfort. As an alternative, the phytochemicals found in daily consumed plants are attractive candidates for clinical/pre-clinical evaluation because of their higher safety. In this context, certain degradation products of glucosinolates (isothiocyanates) are promising agents for cancer prevention and treatment.

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Kushwaha, Prem Prakash, Sunita Kumari Prajapati, Seshu Vardhan Pothabathula, Atul Kumar Singh, Mohd Shuaib, Karnika Joshi, and Shashank Kumar. "Prenylated flavonoids as a promising drug discovery candidate." In Phytochemicals as Lead Compounds for New Drug Discovery, 347–55. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-817890-4.00023-8.

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Tiwari, Nikita, Lubna Jamal, and Anil Mishra. "Virtual Screening of Phytochemicals in Search of a Potential Drug Candidate for COVID-19: DFT Study and Molecular Docking." In COVID-19: Origin, Impact and Management (Part 2), 127–44. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815165944123010012.

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The global health pandemic due to COVID-19 caused by SARS-CoV-2, affected and changed the world’s condition drastically. Herein, we evaluated the bioactivity of some phytochemicals as inhibitors against SARS-CoV-2 M provirus (6LU7) using computational models. We reported the optimization of phytochemicals employing density functional theory (DFT) with B3LYP/6-311G+(d,p) level theory. DFT calculations were employed to determine the free energy, dipole moment as well as chemical reactivity descriptors. Molecular docking has been performed against the SARS-CoV-2 M provirus to search the binding affinity and interactions of all compounds with the respective protein. The known drug, Chloroquine of SARS-CoV-2 main protease, was also docked to evaluate its binding affinity. Besides, the data from DFT, the docking studies predicted that flavonoids (Quercetin, Myricetin, Apigenin and Daidzein) have the least binding affinity and might serve as a potent inhibitor against SARS-CoV-2 comparable with the approved medicine, Chloroquine. The high binding affinity of flavonoids was attributed to the presence of hydrogen bonds along with different hydrophobic interactions between the flavonoid and the critical amino acid residues of the receptor. The DFT calculations showed that flavonoids have high.lying HOMO, electrophilicity index and dipole moment. All these parameters could share a different extent to significantly affect the binding affinity of these phytochemicals with active protein sites.

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Adesanya, S. A., and A. Sofowora. "Phytochemical investigation of candidate plants for the management of sickle cell anaemia." In Phytochemistry of Plants Used in Traditional Medicine, 189–204. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780198577751.003.0008.

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Abstract Sickle cell anaemia (SCA) is a hereditary disease first described by Herrick in 1910. The genes of the patient code for the synthesis in cells of an abnormal haemoglobin HbS, which has /?6-valine instead of /?6-glutamic acid found in normal haemoglobin (HbA) (Murayama 1967). The resultant clinical manifestation of the disease is prominent in patients homozygous for the S gene (HbSS), while heterozygotes with other abnormal genes, such as SC, SThal, or SF, exhibit a milder form of the disease. People with HbAS, however, do not show the symptoms associated with SCA (Lawrence and Wallace 1974). SCA patients suffer characteristically from persistent ulcers, an enlarged spleen, and painful swelling of the digits and joints (Isaacs-Sodeye 1975).

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Joshi, Urja, Dhara Jani, Linz-Bouy George, and Hyacinth Highland. "Antioxidant Efficacy of Selected Plant Extracts Debilitates the Plasmodium Invasion through Erythrocytic Membrane Stabilisation - An In Vitro Study." In Malaria - Recent Advances, and New Perspectives [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106844.

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Most dangerous and prevalent form of malaria is caused by the Plasmodium falciparum mediated malaria and poses the greatest threat to the humans. Emergence of multi drug resistant parasite hindered the prevention of malaria burden worldwide. This study is mainly focused on the erythrocytic membrane stabilisation using regionally available medicinal plant extracts and its corelation with the oxidative stress generated during the intracellular erythrocytic stages development of Plasmodia. The results disclosed that antioxidant potential of the medicinal plants can diminish the reactive oxygen species generation leads to restrict the plasmodial invasion into erythrocytes ultimately decreases the parasitic load. Hence, the evidence of the effective phytochemicals present in the selected medicinal plants can be the promising anti-plasmodial drug candidates as a future perspective.

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Тези доповідей конференцій з теми "PHYTOCHEMICAL CANDIDATES"

Hasan, Ziaul, Asimul Islam, and Luqman Ahmad Khan. "Signature Garlic Phytochemical as a Potential Anti-Candidal Candidate Targeting Virulence Factors in Candida albicans." In International Electronic Conference on Biomedicines. Basel Switzerland: MDPI, 2023. http://dx.doi.org/10.3390/ecb2023-14080.

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