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Статті в журналах з теми "Phoq-phop"
Sanowar, Sarah, Alexandre Martel, and Hervé Le Moual. "Mutational Analysis of the Residue at Position 48 in the Salmonella enterica Serovar Typhimurium PhoQ Sensor Kinase." Journal of Bacteriology 185, no. 6 (March 15, 2003): 1935–41. http://dx.doi.org/10.1128/jb.185.6.1935-1941.2003.
Повний текст джерелаLejona, Sergio, María Eugenia Castelli, María Laura Cabeza, Linda J. Kenney, Eleonora García Véscovi, and Fernando C. Soncini. "PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner." Journal of Bacteriology 186, no. 8 (April 15, 2004): 2476–80. http://dx.doi.org/10.1128/jb.186.8.2476-2480.2004.
Повний текст джерелаGuina, Tina, Eugene C. Yi, Houle Wang, Murray Hackett, and Samuel I. Miller. "A PhoP-Regulated Outer Membrane Protease of Salmonella enterica Serovar Typhimurium Promotes Resistance to Alpha-Helical Antimicrobial Peptides." Journal of Bacteriology 182, no. 14 (July 15, 2000): 4077–86. http://dx.doi.org/10.1128/jb.182.14.4077-4086.2000.
Повний текст джерелаLesley, Joseph A., and Carey D. Waldburger. "Repression of Escherichia coli PhoP-PhoQ Signaling by Acetate Reveals a Regulatory Role for Acetyl Coenzyme A." Journal of Bacteriology 185, no. 8 (April 15, 2003): 2563–70. http://dx.doi.org/10.1128/jb.185.8.2563-2570.2003.
Повний текст джерелаvan Velkinburgh, Jennifer C., and John S. Gunn. "PhoP-PhoQ-Regulated Loci Are Required for Enhanced Bile Resistance in Salmonella spp." Infection and Immunity 67, no. 4 (April 1, 1999): 1614–22. http://dx.doi.org/10.1128/iai.67.4.1614-1622.1999.
Повний текст джерелаLiu, Wen, Xiang Li, Hong Qi, Yuning Wu, Jing Qu, Zhiyong Yin, Xuejuan Gao, Aidong Han, and Jianwei Shuai. "Biphasic regulation of transcriptional surge generated by the gene feedback loop in a two-component system." Bioinformatics 37, no. 17 (March 2, 2021): 2682–90. http://dx.doi.org/10.1093/bioinformatics/btab138.
Повний текст джерелаEguchi, Yoko, Tadashi Okada, Shu Minagawa, Taku Oshima, Hirotada Mori, Kaneyoshi Yamamoto, Akira Ishihama, and Ryutaro Utsumi. "Signal Transduction Cascade between EvgA/EvgS and PhoP/PhoQ Two-Component Systems of Escherichia coli." Journal of Bacteriology 186, no. 10 (May 15, 2004): 3006–14. http://dx.doi.org/10.1128/jb.186.10.3006-3014.2004.
Повний текст джерелаSanowar, Sarah, and Hervé Le Moual. "Functional reconstitution of the Salmonella typhimurium PhoQ histidine kinase sensor in proteoliposomes." Biochemical Journal 390, no. 3 (September 5, 2005): 769–76. http://dx.doi.org/10.1042/bj20050060.
Повний текст джерелаTu, Jian, Boyan Huang, Yu Zhang, Yuxi Zhang, Ting Xue, Shaocan Li, and Kezong Qi. "Modulation of virulence genes by the two-component system PhoP-PhoQ in avian pathogenic Escherichia coli." Polish Journal of Veterinary Sciences 19, no. 1 (March 1, 2016): 31–40. http://dx.doi.org/10.1515/pjvs-2016-0005.
Повний текст джерелаYuan, Jing, Fan Jin, Timo Glatter, and Victor Sourjik. "Osmosensing by the bacterial PhoQ/PhoP two-component system." Proceedings of the National Academy of Sciences 114, no. 50 (November 28, 2017): E10792—E10798. http://dx.doi.org/10.1073/pnas.1717272114.
Повний текст джерелаДисертації з теми "Phoq-phop"
Le, Sage Valerie. "Ligand sensing and signal trasnduction by the two-component system PhoP/PhoQ." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95624.
Повний текст джерелаLa séquence du génome de Citrobacter rodentium présente un opéron phoPQ(~79% identité) homologue à celui de S. typhimurium. Nous avons déterminé quePhoQ de C. rodentium perçoit les variations de pH et en Mg2+ du milieu environnant.De manière surprenante, les PAMs ne causent aucune augmentation d'activité dePhoQ. Néeanmoins, lorsque le système PhoP/PhoQ de C. rodentium est exprimé chezS. typhimurium les PAMs activent PhoQ. Nous avons identifié une protéine de lamembrane externe appartenant à la famille des omptin qui est responsable del'inactivité de PhoQ en présence des P AMs. Ces résultats suggèrent que le mécanismede résistance aux PAMs de C. rodentium serait régulé par le système PhoP/PhoQ et une protéase qui empêcherait la destruction de la membrane externe par les P AMs. Cemécanisme de défense est différent de celui du système PhoP/PhoQ de S. typhimuriumqui repose essentiellement sur des modification du LPS .
Salazar, Michael E. Jr (Michael Edward). "Induction kinetics of the PhoQ-PhoP two-component system in Escherichia coli." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104179.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
Cells rely on signal transduction systems to sense and respond to changes in their enviroments. When a stimulus is present, the corresponding signal transduction system will activate and enact the appropriate biological response, often by modulating target gene expression. In many cases, the temporal dynamics of the activation of target gene expression in the presence of constant stimulus is complex, and often exhibits one or several pulses. How these complex temporal dynamics are regulated at the molecular level is unknown for many signal transduction systems. In this thesis, I discuss the molecular regulation of the temporal dynamics of PhoQ-PhoP induction in Escherichia coli. The PhoQ-PhoP pathway is a canonical two-component system that responds to low extracellular Mg'+, certain antimicrobial peptides, and potentially other unknown factors. Upon activation, the bifunctional histidine kinase PhoQ autophosphorylates and subsequently phosphotransfers to the response regulator PhoP, thereby activating it to increase transcription of PhoP target genes. Because PhoQ is bifunctional, PhoQ acts as a phosphatase on phosphorylated PhoP in the absence of stimulus, thereby keeping the system inactivated. When the PhoQ-PhoP system is strongly induced, PhoP target genes exhibit impulse kinetics, meaning gene expression increases to a maximal level and subsequently decreases to an eventual steady state. We discovered that this impulse response is caused by a negative feedback loop in which active PhoP transcribes mgrB, a gene encoding a small membrane protein that interacts directly with PhoQ to repress the output of the system. MgrB selectively inhibits the ability of PhoQ to phosphorylate PhoP, and permits PhoQ to act as a phosphatase on phosphorylated PhoP. This change in PhoQ activity causes a decrease in the level of active PhoP and the level of PhoP target genes. This thesis reveals how negative feedback loops and histidine kinase bifunctionality can drive the kinetics of two-component system induction in bacteria, and more generally explores how cells regulate changes in gene expression over time.
by Michael E. Salazar, Jr.
Ph. D.
Gellatly, Shaan Lae. "Regulation of the PhoP-PhoQ two-component system in Pseudomonas aeruginosa and its role in virulence." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42991.
Повний текст джерелаRodrigues, Alves Lucas Bocchini. "Patogenicidade de Salmonella Gallinarum com deleção dos genes phoP e phoQ (SG∆phoPQ) em aves comerciais." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152283.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
RESUMO – Salmonella Gallinarum (SG) é um patógeno hospedeiro-específico que causa o tifo aviário, doença sistêmica severa que é considerada uma das principais preocupações da indústria avícola mundial. Quando infecta a ave, SG utiliza mecanismos de evasão para sobreviver e replicar no interior de macrófagos. Nesse contexto, os genes phoPQ codificam o sistema regulatório de dois componentes (PhoPQ) que regula genes de virulência responsáveis pela adaptação de Salmonella spp. a fatores antimicrobianos como baixo pH, peptídeos antimicrobianos e baixas concentrações de cátions bivalentes. No presente estudo, objetivou-se investigar a função desses genes para SG. Assim, uma estirpe de SG com genes phoPQ defectivos (SG ∆phoPQ) foi construída e sua patogenicidade avaliada em aves poedeiras de 20 dias de vida susceptíveis ao tifo aviário. SG ∆phoPQ não causou sinais clínicos nem mortalidade em aves desafiadas oralmente, sendo não-patogênica. Ademais, essa estirpe não foi recuperada de fígados e baços. Por outro lado, aves desafiadas subcutaneamente com a estirpe mutante tiveram alterações patológicas discretas a moderadas e baixas contagens bacterianas em tecidos de fígado e baço. A partir dos dados, observa-se que SG ∆phoPQ é atenuado para aves o que sugere que ambos os genes são importantes durante a infecção sistêmica em aves por SG.
ABSTRACT – Salmonella Gallinarum (SG) is a host-restrict pathogen that causes fowl typhoid, a severe systemic disease that is one of the major concerns to the poultry industry worldwide. When infecting the bird, SG makes use of evasion mechanisms to survive and to replicate within macrophages. In this context, phoPQ genes encode a two-component regulatory system (PhoPQ) that regulates virulence genes responsible for adaptation of Salmonella spp. to antimicrobial factors such as low pH, antimicrobial peptides and deprivation of bivalent cations. Herein, we aimed to investigate the role of the mentioned genes to SG. Thus, a phoPQ-depleted SG strain (SG ∆phoPQ) was constructed and its virulence assessed in twenty-day-old laying hens susceptible to fowl typhoid. SG ∆phoPQ did cause neither clinical signs nor mortality in birds orally challenged, being non-pathogenic. Furthermore, this strain was not recovered from livers or spleens. On the other hand, chickens challenged subcutaneously with the mutant strain had discreet to moderate pathological changes and also low bacterial counts in liver and spleen tissues. These findings show that SG ∆phoPQ is attenuated to susceptible chickens and suggest that both genes are important during chicken systemic infection by SG.
Coornaert, Audrey. "Etude de la régulation post-transcriptionnelle de l'expression du système à deux composants PhoQ-PhoP par les ARN régulateurs chez Escherichia coli." Paris 7, 2012. http://www.theses.fr/2012PA077129.
Повний текст джерелаBacteria have developed many strategies allowing them to adapt and live in ever changing environments. Among them, two- component Systems are key regulators of transcription: in most cases, a histidine kinase protein, stimulated by specific signals, activates its cognate response regulator, leading to regulation of the expression of target genes. PhoQ-PhoP is one of those two-component Systems, and is activated by low extracellular magnesium concentration, low pH or antimicrobial peptides. In response, it activates the expression of dozens of genes involved in magnesium import, bacterial virulence or response to acid stress. Small regulatory RNAs are also involved in the rapid adaptation of gene expression to the environment. In bacteria, there is a particular class, whose activity is dependent on the RNA chaperone Hfq. They act by pairing with target mRNA(s) via imperfect duplexes and modify, either positively or negatively, target mRNA translation and/or stability. We have showed that MicA and GcvB, two Hfq-dependent small regulatory RNAs, directly dowriregulate PhoQ-PhoP synthesis by pairing with the translation initiation region of the first cistron ofphoPQ mRNA, thereby inhibiting binding of the small ribosomal subunit. Surprinsingly, these regulations differently affect expression of the PhoP regulon: MicA has, as expected, a negative effet on the regulon, while GcvB seems to have a positive effect. This unexpected result is still under investigation but seems to be related to a pleiotropic effect of GcvB in the cell. More generally, we highlighted a link between three different bacterial adaptative regulatory Systems: sRNA, two-component Systems and sigma factors
Nordesjö, Olle. "Searching for novel protein-protein specificities using a combined approach of sequence co-evolution and local structural equilibration." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275040.
Повний текст джерелаKwasnicka, Agnieszka. "Identification of PhoP-PhoQ homologues in Pseudomonas aeruginosa responsible for regulation of the outer membrane protein OprH." Thesis, 1999. http://hdl.handle.net/2429/9660.
Повний текст джерелаЧастини книг з теми "Phoq-phop"
Miller, Samuel I. "PhoP/PhoQ: Regulating Salmonella Adaptation to Host Microenvironments." In Signal Transduction and Bacterial Virulence, 61–77. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-662-22406-9_5.
Повний текст джерелаТези доповідей конференцій з теми "Phoq-phop"
Kravchenko, V. A., N. E. Gogoleva, A. N. Crook, Yu V. Dubo, Y. V. Gogolev, and E. A. Nikolaychik. "The role of the two-component system PhoQ / PhoP Pectobacterium carotovorum in interaction withhost-plant." In IX Congress of society physiologists of plants of Russia "Plant physiology is the basis for creating plants of the future". Kazan University Press, 2019. http://dx.doi.org/10.26907/978-5-00130-204-9-2019-235.
Повний текст джерелаHarari, Oscar, Coral del Val, and Igor Zwir. "Integrating network motifs into a genetic network: A case of study based on the Phop/PhoQ two-component system." In 2011 11th International Conference on Intelligent Systems Design and Applications (ISDA). IEEE, 2011. http://dx.doi.org/10.1109/isda.2011.6121851.
Повний текст джерела