Статті в журналах: "PHM for medical microdevices"

1

Chamorro Fuertes, John Euler, and Oscar Andrés Vivas Albán. "Microdevices:." Ingeniería Solidaria 18, no. 3 (September 12, 2022): 1–24. http://dx.doi.org/10.16925/2357-6014.2022.03.11.

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Abstract: This article reviews the literature on the latest advances in microdevices for medical applications. The objective is to show an overview of the latest devices and their applications, as well as future development vectors in the area. A search of about 170 articles was performed, most of them published between the years 2015 and 2021, of which 53 were chosen as they were the most topical and impactful in the research fields referred to drug delivery, minimally invasive surgery, and cranial and vascular intromissions. It is concluded that, although microdevices are at an advanced stage of research, they still have many challenges to be solved, which has not allowed clinical trials to be completed in many cases. One of the great challenges ahead is to increase the precision in locomotion and to make the devices capable of performing more complex tasks with the help of smaller-scale electronic devices.

2

Elman, NM, Y. Patta, AW Scott, B. Masi, HL Ho Duc, and MJ Cima. "The Next Generation of Drug-Delivery Microdevices." Clinical Pharmacology & Therapeutics 85, no. 5 (February 25, 2009): 544–47. http://dx.doi.org/10.1038/clpt.2009.4.

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Tuncer, Mustafa, Feray Bakan, Hasan Gocmez, and Emre Erdem. "Capacitive behaviour of nanocrystalline octacalcium phosphate (OCP) (Ca8H2(PO4)6·5H2O) as an electrode material for supercapacitors: biosupercaps." Nanoscale 11, no. 39 (2019): 18375–81. http://dx.doi.org/10.1039/c9nr07108c.

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4

Li, Wen, and Zhen Qiu. "Editorial for the Special Issue on Implantable Microdevices." Micromachines 10, no. 9 (September 12, 2019): 603. http://dx.doi.org/10.3390/mi10090603.

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Implantable microdevices, providing accurate measurement of target analytes in animals and humans, have always been important in biological science, medical diagnostics, clinical therapy, and personal healthcare [...]

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Belaala, Abir, Zeina Al Masry, Labib Sadek Terrissa, and Noureddine Zerhouni. "Retargeting PHM tools: from industrial to medical field." PHM Society European Conference 5, no. 1 (July 22, 2020): 7. http://dx.doi.org/10.36001/phme.2020.v5i1.1232.

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Prognostics and Health Management (PHM) approach, and theoretical models have had great success for industrial systems. Therefore, this accomplishment motivates us to think about potential extension of the PHM approach in such area as the medicine. The aim of this paper is to apply an adaptation of a PHM model from fault diagnosis of aircraft engine to diagnosis human heart disease. For that adaptation, an algorithm for retargeting extreme learning machine (ID-RELM) is applied. The complete process from data pre-processing to classification is developed. Numerical results using heart disease benchmark dataset showed that the combination of random forest and ID-RELM provides the highest classification accuracy and outperforms other algorithms in classifying this chronic disease status.

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Metzger, J. M., and R. H. Fitts. "Role of intracellular pH in muscle fatigue." Journal of Applied Physiology 62, no. 4 (April 1, 1987): 1392–97. http://dx.doi.org/10.1152/jappl.1987.62.4.1392.

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Intracellular pH of in vitro diaphragm preparations was determined following low- (5 Hz, 1.5 min) and high- (75 Hz, 1 min) frequency stimulation, using glass microelectrodes of the liquid membrane type (pHm). Results were compared with values obtained by the standard homogenate technique (pHh). High- and low-frequency stimulation reduced peak tetanic tension to 21 +/- 1 (SE) and 71 +/- 2% of initial values, respectively. Peak tetanic tension returned to resting values after 10- to 15-min recovery from high- or low-frequency stimulation. Resting pHm was 7.063 +/- 0.011 (n = 72), and after fatiguing stimulation declined to values as low as 6.33. During recovery pHm significantly increased and by 10 min had returned to prefatigue values. No difference was observed in the recovery of pHm between the low- and high-frequency stimulation groups (analysis of variance test, ANOVA), and in both groups pHm recovery was highly correlated to the recovery of peak tetanic tension (r = 0.94, P less than 0.001). Resting pHh was 7.219 +/- 0.023 (n = 13), which was significantly higher than the pHm value. In contrast to pHm, intracellular pHh was significantly higher during recovery from 75- vs. 5-Hz stimulation (P less than 0.05). For both groups pHh increased significantly with time and by 10 min returned to prestimulation values. The ANOVA test demonstrated that pHh values were significantly higher than pHm values during recovery from fatigue. The results from this study support our hypothesis that fatigue from both high- and low-frequency stimulation is at least partially due to the deleterious effects of intracellular acidosis on excitation-contraction coupling.

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Spriet, L. L., K. Soderlund, M. Bergstrom, and E. Hultman. "Skeletal muscle glycogenolysis, glycolysis, and pH during electrical stimulation in men." Journal of Applied Physiology 62, no. 2 (February 1, 1987): 616–21. http://dx.doi.org/10.1152/jappl.1987.62.2.616.

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Glycogenolytic and glycolytic rates were estimated and muscle pH (pHm) was measured in electrically stimulated quadriceps femoris muscles of seven men. Leg blood flow was occluded and muscles were stimulated 64 times at 20 Hz, with contractions lasting 1.6 s and separated by pauses of 1.6 s. Muscle biopsies were obtained at rest and following 16, 32, 48, and 64 contractions. Glycolytic intermediates and several modulators of the glycolytic enzyme phosphofructokinase (PFK) were measured. Glycogenolytic and glycolytic rates were 1.68 and 1.26 mmol glucosyl units X kg dry muscle-1 X S-1 contraction time during the initial 16 contractions and pHm decreased from 7.00 +/- 0.01 to 6.70 +/- 0.03. During the subsequent 32 contractions both glycogenolytic and glycolytic rates were maintained at approximately 0.70 mmol X kg-1 X S-1 and pHm decreased to 6.45 +/- 0.04. In the final 16 contractions, both rates were very low and pHm was unchanged. Therefore, PFK remained active despite increasing acidity until pHm decreased to approximately 6.45. We conclude that increases in the concentrations of several positive modulators partially reverses pH-dependent ATP inhibition of PFK in vivo, permitting glycolytic activity to continue in the pHm range of 6.70–6.45.

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Sharma, Suresh D., Gayatri Raghuraman, Myeong-Seon Lee, Nanduri R. Prabhakar та Ganesh K. Kumar. "Intermittent hypoxia activates peptidylglycine α-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing". Journal of Applied Physiology 106, № 1 (січень 2009): 12–19. http://dx.doi.org/10.1152/japplphysiol.90702.2008.

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Intermittent hypoxia (IH) associated with sleep apneas leads to cardiorespiratory abnormalities that may involve altered neuropeptide signaling. The effects of IH on neuropeptide synthesis have not been investigated. Peptidylglycine α-amidating monooxygenase (PAM; EC 1.14.17.3) catalyzes the α-amidation of neuropeptides, which confers biological activity to a large number of neuropeptides. PAM consists of O2-sensitive peptidylglycine α-hydroxylating monooxygenase (PHM) and peptidyl-α-hydroxyglycine α-amidating lyase (PAL) activities. Here, we examined whether IH alters neuropeptide synthesis by affecting PAM activity and, if so, by what mechanisms. Experiments were performed on the brain stem of adult male rats exposed to IH (5% O2for 15 s followed by 21% O2for 5 min; 8 h/day for up to 10 days) or continuous hypoxia (0.4 atm for 10 days). Analysis of brain stem extracts showed that IH, but not continuous hypoxia, increased PHM, but not PAL, activity of PAM and that the increase of PHM activity was associated with a concomitant elevation in the levels of α-amidated forms of substance P and neuropeptide Y. IH increased the relative abundance of 42- and 35-kDa forms of PHM (∼1.6- and 2.7-fold, respectively), suggesting enhanced proteolytic processing of PHM, which appears to be mediated by an IH-induced increase of endoprotease activity. Kinetic analysis showed that IH increases Vmaxbut has no effect on Km. IH increased generation of reactive oxygen species in the brain stem, and systemic administration of antioxidant prevented IH-evoked increases of PHM activity, proteolytic processing of PHM, endoprotease activity, and elevations in substance P and neuropeptide Y amide levels. Taken together, these results demonstrate that IH activates PHM in rat brain stem via reactive oxygen species-dependent posttranslational proteolytic processing and further suggest that PAM activation may contribute to IH-mediated peptidergic neurotransmission in rat brain stem.

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Spriet, L. L., K. Soderlund, J. A. Thomson, and E. Hultman. "pH measurement in human skeletal muscle samples: effect of phosphagen hydrolysis." Journal of Applied Physiology 61, no. 5 (November 1, 1986): 1949–54. http://dx.doi.org/10.1152/jappl.1986.61.5.1949.

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Measurements of muscle pH (pHm) with the homogenate technique are routinely made when extensive phosphagen hydrolysis has occurred. Upon exposure of the homogenate to 37 degrees C in the pH meter, phosphocreatine and ATP were rapidly degraded to 35 and 60% of control concentrations after 30 s. Attempts at chemically arresting this hydrolysis were unsuccessful. Therefore we examined the significance of phosphagen hydrolysis on pHm measurement in human biopsies taken at rest and following intense electrical stimulation. To accomplish this, pHm was measured at 0 degree C, where extensive hydrolysis did not occur. On the same homogenate, pHm was measured at 0 degree C with phosphagens and at 0 and 37 degrees C after phosphagen hydrolysis. The effect of phosphagen hydrolysis on pHm at 0 degrees C was used to estimate this effect at 37 degrees C. In resting samples, phosphagen hydrolysis produced a nonsignificant acidification of 0.008 pH units and, in electrically stimulated samples, a nonsignificant alkalinization of 0.033 units. Measurements of homogenate PCO2 suggested that most of the CO2 remained in the sample during pHm measurement at 37 degrees C. The present work substantiates the use of the homogenate technique as an accurate and practical method for the estimation of intracellular pH in resting and exercise human muscle samples.

10

Granger, Carl V., Marsha Carlin, Pedro Diaz, Jane Dorval, Steve Forer, Corby Kessler, John L. Melvin, Lawrence S. Miller, Richard V. Riggs, and Pamela Roberts. "Medical Necessity." American Journal of Physical Medicine & Rehabilitation 88, no. 9 (September 2009): 755–65. http://dx.doi.org/10.1097/phm.0b013e3181aa71a8.

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Palmer, J. B., F. M. Cuss, and P. J. Barnes. "VIP and PHM and their role in nonadrenergic inhibitory responses in isolated human airways." Journal of Applied Physiology 61, no. 4 (October 1, 1986): 1322–28. http://dx.doi.org/10.1152/jappl.1986.61.4.1322.

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There is increasing evidence in many species that vasoactive intestinal peptide (VIP) may be a neurotransmitter in nonadrenergic inhibitory nerves. We have studied the effect of electrical field stimulation (EFS), exogenous VIP, and isoproterenol (Iso) on human airways in vitro. We have also studied a related peptide, peptide histidine methionine (PHM), which coexists with VIP in human airway nerves, and in separate experiments studied fragments of the VIP amino acid sequence (VIP1–10 and VIP16–28) for agonist and antagonist activity. Human airways were obtained at thoracotomy and studied in an organ bath. In bronchi EFS gave an inhibitory response that was unaltered by 10(-6) M propranolol but was blocked by tetrodotoxin, whereas in bronchioles there was little or no nonadrenergic inhibitory response. VIP, PHM, and Iso all caused dose-dependent relaxation of bronchi, VIP and PHM being approximately 50-fold more potent than Iso. VIP, but not Iso, mimicked the time course of nonadrenergic inhibitory nerve stimulation. In contrast bronchioles relaxed to Iso but not to VIP or PHM. Neither propranolol nor indomethacin altered the relaxant effects of VIP or PHM, suggesting a direct effect of these peptides on airway smooth muscle. Neither of the VIP fragments showed either agonist or antagonist activity. We conclude that VIP and PHM are more potent bronchodilators of human bronchi than Iso and that the association between the relaxant effects of these peptides and nonadrenergic inhibitory responses suggests that they may be possible neurotransmitters of nonadrenergic inhibitory nerves in human airways.

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Yamahira, Shinya, and Yuji Heike. "Facile Fabrication of Thin-Bottom Round-Well Plates Using the Deformation of PDMS Molds and Their Application for Single-Cell PCR." Micromachines 11, no. 8 (July 31, 2020): 748. http://dx.doi.org/10.3390/mi11080748.

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Recently, microdevices made of resins have been strongly supporting cell analysis in a range of fields, from fundamental life science research to medical applications. Many microdevices are fabricated by molding resin to a mold made precisely from rigid materials. However, because dimensional errors in the mold are also accurately printed to the products, the accuracy of the product is limited to less than the accuracy of the rigid mold. Therefore, we hypothesized that if dimensional errors could be self-corrected by elastic molds, microdevices could be facilely fabricated with precision beyond that of molds. In this paper, we report a novel processing strategy in which an elastic mold made of polymethylsiloxane (PDMS) deforms to compensate for the dimensional error on the products. By heat-press molding a polycarbonate plate using a mold that has 384 PDMS convexes with a large dimensional error of height of ± 15.6 µm in standard deviation, a 384-round-well plate with a bottom thickness 13.3 ± 2.3 µm (n = 384) was easily fabricated. Finally, single-cell observation and polymerase chain reactions (PCRs) demonstrated the application of the products made by elastic PDMS molds. Therefore, this processing method is a promising strategy for facile, low-cost, and higher precision microfabrication.

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Musteata, Florin Marcel. "Pharmacokinetic applications of microdevices and microsampling techniques." Bioanalysis 1, no. 1 (April 2009): 171–85. http://dx.doi.org/10.4155/bio.09.18.

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Kirch, Darrell G. "Medical Educators and Physiatrists." American Journal of Physical Medicine & Rehabilitation 89, no. 11 (November 2010): 945–49. http://dx.doi.org/10.1097/phm.0b013e3181f71458.

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McPeak, Lisa A. "Medical Aspects of Disability." American Journal of Physical Medicine & Rehabilitation 90, no. 8 (August 2011): 627. http://dx.doi.org/10.1097/phm.0b013e31821a6cf5.

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Baptista, Vitória, Weng Kung Peng, Graça Minas, Maria Isabel Veiga, and Susana O. Catarino. "Review of Microdevices for Hemozoin-Based Malaria Detection." Biosensors 12, no. 2 (February 11, 2022): 110. http://dx.doi.org/10.3390/bios12020110.

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Despite being preventable and treatable, malaria still puts almost half of the world’s population at risk. Thus, prompt, accurate and sensitive malaria diagnosis is crucial for disease control and elimination. Optical microscopy and immuno-rapid tests are the standard malaria diagnostic methods in the field. However, these are time-consuming and fail to detect low-level parasitemia. Biosensors and lab-on-a-chip devices, as reported to different applications, usually offer high sensitivity, specificity, and ease of use at the point of care. Thus, these can be explored as an alternative for malaria diagnosis. Alongside malaria infection inside the human red blood cells, parasites consume host hemoglobin generating the hemozoin crystal as a by-product. Hemozoin is produced in all parasite species either in symptomatic and asymptomatic individuals. Furthermore, hemozoin crystals are produced as the parasites invade the red blood cells and their content relates to disease progression. Hemozoin is, therefore, a unique indicator of infection, being used as a malaria biomarker. Herein, the so-far developed biosensors and lab-on-a-chip devices aiming for malaria detection by targeting hemozoin as a biomarker are reviewed and discussed to fulfil all the medical demands for malaria management towards elimination.

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Perret, Danielle, and Tiffany Knowlton. "Physiatric Patient Care, Graduate Medical Education Training, and Graduate Medical Education Funding." American Journal of Physical Medicine & Rehabilitation 96, no. 9 (September 2017): 663–64. http://dx.doi.org/10.1097/phm.0000000000000788.

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Mayer, R. Samuel, Jennifer Baima, Rina Bloch, Diana Braza, Karen Newcomer, Andrew Sherman, and William Sullivan. "Musculoskeletal Education for Medical Students." American Journal of Physical Medicine & Rehabilitation 88, no. 10 (October 2009): 791–97. http://dx.doi.org/10.1097/phm.0b013e3181b72a3e.

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Kumar, Prashant, Salman Khalid, and Heung Soo Kim. "Prognostics and Health Management of Rotating Machinery of Industrial Robot with Deep Learning Applications—A Review." Mathematics 11, no. 13 (July 6, 2023): 3008. http://dx.doi.org/10.3390/math11133008.

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The availability of computational power in the domain of Prognostics and Health Management (PHM) with deep learning (DL) applications has attracted researchers worldwide. Industrial robots are the prime mover of modern industry. Industrial robots comprise multiple forms of rotating machinery, like servo motors and numerous gears. Thus, the PHM of the rotating components of industrial robots is crucial to minimize the downtime in the industries. In recent times, deep learning has proved its mettle in different areas, like bio-medical, image recognition, speech recognition, and many more. PHM with DL applications is a rapidly growing field. It has helped achieve a better understanding of the different condition monitoring signals, like vibration, current, temperature, acoustic emission, partial discharge, and pressure. Most current review articles are component- (or system-)specific and have not been updated to reflect the new deep learning approaches. Also, a unified review paper for PHM strategies for industrial robots and their rotating machinery with DL applications has not previously been presented. This paper presents a review of the PHM strategies with various DL algorithms for industrial robots and rotating machinery, along with brief theoretical aspects of the algorithms. This paper presents a trend of the up-to-date advancements in PHM approaches using DL algorithms. Also, the restrictions and challenges associated with the available PHM approaches are discussed, paving the way for future studies.

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Robinson, Lawrence R. "Another View on Medical Care Delivery." American Journal of Physical Medicine & Rehabilitation 94, no. 6 (June 2015): e50. http://dx.doi.org/10.1097/phm.0000000000000282.

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Esselman, Peter, David Berbrayer, Janna Friedly, Carl Granger, and R. Sam Mayer. "Chronic Care Education in Medical School." American Journal of Physical Medicine & Rehabilitation 88, no. 10 (October 2009): 798–804. http://dx.doi.org/10.1097/phm.0b013e3181b72bbe.

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&NA;. "Musculoskeletal Education for Medical Students: Erratum." American Journal of Physical Medicine & Rehabilitation 89, no. 2 (February 2010): 140. http://dx.doi.org/10.1097/phm.0b013e3181cbcec3.

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Rassbach, Caroline E., and Darren Fiore. "Research and Career Outcomes for Pediatric Hospital Medicine Fellowship Graduates." Hospital Pediatrics 11, no. 10 (October 1, 2021): 1082–114. http://dx.doi.org/10.1542/hpeds.2021-005938.

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OBJECTIVES Pediatric hospital medicine (PHM) fellowships have rapidly developed to meet established needs. The purpose of this research was to describe the research and career outcomes of PHM fellowship graduates. We hypothesized that graduates would report significant research and academic productivity. METHODS This was an institutional review board–approved, cross-sectional survey of PHM fellowship graduates in 2018. The 88-item survey was modified from an existing survey, developed by experts to address study objectives and pilot tested, and it included quantitative and qualitative items to assess characteristics of fellowship training and research and career outcomes. RESULTS A total of 63% of PHM fellowship graduates (143 of 228) completed the survey (graduation dates, 2000–2018). In total, 89% graduated from dedicated PHM fellowship programs, with 59% completing a 2-year fellowship and 78% now practicing primarily at a university or children’s hospital. Fellows conducted research in clinical research (53%), quality improvement (41%), health services (24%), and medical education (19%). A total of 77% of graduates continued to do research after graduation, with 63% publishing and 25% obtaining grant funding. Graduates of 2- and 3-year fellowships and those with a master’s degree were significantly more productive. Graduates now hold important roles in academic and health systems leadership. Graduates are highly satisfied with their decision to do PHM fellowship and identified 5 themes regarding how fellowship impacted their career outcomes. CONCLUSIONS In this study, we document robust research activity and leadership positions among PHM fellowship graduates and can serve as a benchmark for metrics that PHM educational leaders can use to assess outcomes and improve training regarding research and career development.

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Barr, Karen P., and Teresa L. Massagli. "New Challenges for the Graduate Medical Educator." American Journal of Physical Medicine & Rehabilitation 93, no. 7 (July 2014): 624–31. http://dx.doi.org/10.1097/phm.0000000000000073.

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Bach, John R., and Joel DeLisa. "An Alternative View on Medical Care Delivery." American Journal of Physical Medicine & Rehabilitation 93, no. 12 (December 2014): 1095–99. http://dx.doi.org/10.1097/phm.0000000000000231.

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LaBan, Myron M. "Predatory Open-Access Medical Publishers “Caveat Emptor”." American Journal of Physical Medicine & Rehabilitation 98, no. 2 (February 2019): e13-e14. http://dx.doi.org/10.1097/phm.0000000000001009.

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Ioerger, Michael, Reed M. Flanders, Jeremy R. French-Lawyer, and Margaret A. Turk. "Interventions to Teach Medical Students About Disability." American Journal of Physical Medicine & Rehabilitation 98, no. 7 (July 2019): 577–99. http://dx.doi.org/10.1097/phm.0000000000001154.

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Mohan, Manoj, Amy Schnappinger, and Brad E. Dicianno. "The Rehabilitation Research Experience for Medical Students." American Journal of Physical Medicine & Rehabilitation 98, no. 11 (November 2019): 1026–30. http://dx.doi.org/10.1097/phm.0000000000001233.

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Granger, Carl V., Samuel J. Markello, James E. Graham, Anne Deutsch, and Kenneth J. Ottenbacher. "The Uniform Data System for Medical Rehabilitation." American Journal of Physical Medicine & Rehabilitation 88, no. 12 (December 2009): 961–72. http://dx.doi.org/10.1097/phm.0b013e3181c1ec38.

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Granger, Carl V., Samuel J. Markello, James E. Graham, Anne Deutsch, Timothy A. Reistetter, and Kenneth J. Ottenbacher. "The Uniform Data System for Medical Rehabilitation." American Journal of Physical Medicine & Rehabilitation 89, no. 4 (April 2010): 265–78. http://dx.doi.org/10.1097/phm.0b013e3181d3eb20.

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Granger, Carl V., Samuel J. Markello, James E. Graham, Anne Deutsch, Timothy A. Reistetter, and Kenneth J. Ottenbacher. "The Uniform Data System for Medical Rehabilitation." American Journal of Physical Medicine & Rehabilitation 89, no. 10 (October 2010): 781–94. http://dx.doi.org/10.1097/phm.0b013e3181f1c83a.

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Thompson, Jeffrey M., Connie A. Luedtke, Terry H. Oh, Nilay D. Shah, Kirsten Hall Long, Susan King, Megan Branda, and Randy Swanson. "Direct Medical Costs in Patients with Fibromyalgia." American Journal of Physical Medicine & Rehabilitation 90, no. 1 (January 2011): 40–46. http://dx.doi.org/10.1097/phm.0b013e3181fc7ff3.

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Granger, Carl V., Timothy A. Reistetter, James E. Graham, Anne Deutsch, Samuel J. Markello, Paulette Niewczyk, and Kenneth J. Ottenbacher. "The Uniform Data System for Medical Rehabilitation." American Journal of Physical Medicine & Rehabilitation 90, no. 3 (March 2011): 177–89. http://dx.doi.org/10.1097/phm.0b013e31820b18d7.

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Granger, Carl V., Amol M. Karmarkar, James E. Graham, Anne Deutsch, Paulette Niewczyk, Margaret A. DiVita, and Kenneth J. Ottenbacher. "The Uniform Data System for Medical Rehabilitation." American Journal of Physical Medicine & Rehabilitation 91, no. 4 (April 2012): 289–99. http://dx.doi.org/10.1097/phm.0b013e31824ad2fd.

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Galloway, Rebecca V., Carl V. Granger, Amol M. Karmarkar, James E. Graham, Anne Deutsch, Paulette Niewczyk, Margaret A. DiVita, and Kenneth J. Ottenbacher. "The Uniform Data System for Medical Rehabilitation." American Journal of Physical Medicine & Rehabilitation 92, no. 1 (January 2013): 14–27. http://dx.doi.org/10.1097/phm.0b013e31827441bc.

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Graham, James E., Carl V. Granger, Amol M. Karmarkar, Anne Deutsch, Paulette Niewczyk, Margaret A. DiVita, and Kenneth J. Ottenbacher. "The Uniform Data System for Medical Rehabilitation." American Journal of Physical Medicine & Rehabilitation 93, no. 3 (March 2014): 231–44. http://dx.doi.org/10.1097/phm.0b013e3182a92c58.

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Phayre, A. "Microdevices for Biological Analyses Recent Advances and Directions for the Future." Journal of the Association for Laboratory Automation 5, no. 4 (September 1, 2000): 78–82. http://dx.doi.org/10.1016/s1535-5535(04)00088-7.

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Phayre, Allison N., Nanette K. Hartley, and Mark A. Hayes. "Microdevices for Biological Analyses Recent Advances and Directions for the Future." JALA: Journal of the Association for Laboratory Automation 5, no. 4 (August 2000): 78–82. http://dx.doi.org/10.1016/s1535-5535-04-00088-7.

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Arens, Johann H., Wolfgang Hauth, and Joerg Weissmann. "Novel App- and Web-Supported Diabetes Prevention Program to Promote Weight Reduction, Physical Activity, and a Healthier Lifestyle: Observation of the Clinical Application." Journal of Diabetes Science and Technology 12, no. 4 (March 27, 2018): 831–38. http://dx.doi.org/10.1177/1932296818768621.

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Background: The increasing incidence of type 2 diabetes mellitus presents as a tsunami of health problems and health care costs. Preventing this development needs to target the underlying rise in metabolic syndrome cases through obesity and unhealthy lifestyle. Obesity is frequently perceived as a social issue with implicit psychological strain; health apps/weight-reduction programs are mushrooming from this side. The present program intends to bring weight reduction into the hands of HCPs by utilizing advanced digital technology. Methods: The prospective observational study analyzed 166 patients with metabolic syndrome as treated for weight reduction in 23 medical practices in Germany. Two approaches were observed: usual care (UC; n = 57) and a personalized health management program (PHM; n = 109). Key for PHM was the interaction between HCP and patient: reinforcing lifestyle changes through personalized goals and HCP-feedback via app- and web-based communication. Comparing PHM/UC was based on a time-to-success (5% weight reduction) analysis by Cox regression. Further exploratory analyses addressed the comparison of achievers and nonachievers. Results: Cox regression adjusted for sex, age, and BMI revealed a chance ratio for weight reduction of 6.2 (2.4-16.2, p = .0003) favoring PHM. Expected success rates were 44.8% for PHM, 11.5% for UC. PHM achievers reduced their weight by 8.0% and lowered their BMI by 2.7 points. Motivation for lifestyle changes represented a key for success. Conclusions: The approach of enhanced interaction of HCPs and patients via app- and web-based communication was a clear success and delivered favorable responder rates. Treating obesity from a medical viewpoint will help to deepen the motivation for changing lifestyles. The study represents a cornerstone for a wider scoped application of these novel digital health approaches.

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Moutsiakis, Demetrius, and Thomas Polisoto. "Reassessing Physical Disability Among Graduating US Medical Students." American Journal of Physical Medicine & Rehabilitation 89, no. 11 (November 2010): 923–30. http://dx.doi.org/10.1097/phm.0b013e3181ec939d.

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Vetere, Peter, and Suzette Cooke. "Preparedness to practice paediatric hospital medicine." Paediatrics & Child Health 25, no. 7 (September 24, 2019): 447–54. http://dx.doi.org/10.1093/pch/pxz113.

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Abstract Background The field of paediatric hospital medicine (PHM) is evolving to meet the needs of an increasingly complex paediatric population, lead quality improvement initiatives, and conduct field-specific teaching and research. Over 50 subspecialty PHM fellowship programs exist in the USA and Canada and more are under active development to ensure trainees are prepared to perform competencies specific to the field following transition to independent practice. Objective The objective of this study was to assess the perceived preparedness of recently graduated general paediatric residents and recently certified staff paediatricians in Canada with respect to the practice of PHM. Methods A survey based on the ‘Objectives of Training in Pediatrics’ of the Royal College of Physicians and Surgeons of Canada (RCPSC) was distributed to graduating paediatric residents and recently graduated staff paediatricians (2013 to 2017) practicing in the hospital setting. Qualitative comments were also obtained. Results Fifty-five surveys were completed (50%). Respondents perceived that, at the on-set of starting practice, they would require assistance or consultation with the majority of representative PHM task competencies. Differences in perception between the two groups were minimal. Our study identified sub-sets of perceived areas of particular strengths (Professional) and deficiencies (Medical Expert, Manager, and Scholar). Conclusions Results may help inform future curricula for general paediatric residency programs and provide insight into competencies that may be better targeted for PHM fellowship training programs. This study may also stimulate discussion regarding entrustable professional activities for paediatric curricula as the medical community shifts to a new paradigm of outcome-based assessment.

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Elman, N. M., and U. M. Upadhyay. "Medical Applications of Implantable Drug Delivery Microdevices Based on MEMS (Micro-Electro-Mechanical-Systems)." Current Pharmaceutical Biotechnology 11, no. 4 (June 1, 2010): 398–403. http://dx.doi.org/10.2174/138920110791233262.

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McRae, Michael P., Glennon Simmons, and John T. McDevitt. "Challenges and opportunities for translating medical microdevices: insights from the programmable bio-nano-chip." Bioanalysis 8, no. 9 (May 2016): 905–19. http://dx.doi.org/10.4155/bio-2015-0023.

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Seidel, Erica, and Scott Crowe. "The State of Disability Awareness in American Medical Schools." American Journal of Physical Medicine & Rehabilitation 96, no. 9 (September 2017): 673–76. http://dx.doi.org/10.1097/phm.0000000000000719.

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Gans, Bruce M. "Impact of the “60% Rule” on Inpatient Medical Rehabilitation." American Journal of Physical Medicine & Rehabilitation 87, no. 4 (April 2008): 255–57. http://dx.doi.org/10.1097/phm.0b013e31816c0439.

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Elías-Grajeda, Alex, Elisa Vázquez-Lepe, Héctor R. Siller, Imperio Anel Perales-Martínez, Emiliano Reséndiz-Hernández, Claudia Angélica Ramírez-Herrera, Daniel Olvera-Trejo, and Oscar Martínez-Romero. "Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process." Polymers 15, no. 14 (July 15, 2023): 3049. http://dx.doi.org/10.3390/polym15143049.

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In recent years, there has been a growing demand for biocompatible medical devices on the microscale. However, the manufacturing of certain microfeatures has posed a significant challenge. To address this limitation, a new process called ultrasonic injection molding or ultrasonic molding (USM) has emerged as a potential solution. In this study, we focused on the production of a specific microdevice known as Hem-O-Lok, which is designed for ligation and tissue repair during laparoscopic surgery. Utilizing USM technology, we successfully manufactured the microdevice using a nonabsorbable biopolymer that offers the necessary flexibility for easy handling and use. To ensure high-quality microdevices, we extensively investigated various processing parameters such as vibration amplitude, temperature, and injection velocity. Through careful experimentation, we determined that the microdevice achieved optimal quality when manufactured under conditions of maximum vibrational amplitude and temperatures of 50 and 60 °C. This conclusion was supported by measurements of critical microfeatures. Additionally, our materials characterization efforts revealed the presence of a carbonyl (C=O) group resulting from the thermo-oxidation of air in the plasticizing chamber. This finding contributes to the enhanced thermal stability of the microdevices within a temperature range of 429–437 °C.

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Raeissadat, Seyed Ahmad, Behnoud Samadi, Seyed Mansour Rayegani, Mohammad Hasan Bahrami, and Hooman Mahmoudi. "Survey of Medical Residents’ Attitude Toward Physical Medicine and Rehabilitation." American Journal of Physical Medicine & Rehabilitation 93, no. 6 (June 2014): 540–47. http://dx.doi.org/10.1097/phm.0000000000000057.

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Bach, John R. "Medical Considerations of Long-Term Survival of Werdnig???Hoffmann Disease." American Journal of Physical Medicine & Rehabilitation 86, no. 5 (May 2007): 349–55. http://dx.doi.org/10.1097/phm.0b013e31804b1d66.

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Dicianno, Brad E., Brad G. Kurowski, Jennifer Marie J. Yang, Michael B. Chancellor, Ghassan K. Bejjani, Andrea D. Fairman, Nancy Lewis, and Jennifer Sotirake. "Rehabilitation and Medical Management of the Adult with Spina Bifida." American Journal of Physical Medicine & Rehabilitation 87, no. 12 (December 2008): 1027–50. http://dx.doi.org/10.1097/phm.0b013e31818de070.

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Kirby, Ronald Lee, Kelsey A. Crawford, Cher Smith, Kara J. Thompson, and Joan M. Sargeant. "A Wheelchair Workshop for Medical Students Improves Knowledge and Skills." American Journal of Physical Medicine & Rehabilitation 90, no. 3 (March 2011): 197–206. http://dx.doi.org/10.1097/phm.0b013e318206398a.

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