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Статті в журналах з теми "PHM for medical microdevices":
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Chamorro Fuertes, John Euler, and Oscar Andrés Vivas Albán. "Microdevices:." Ingeniería Solidaria 18, no. 3 (September 12, 2022): 1–24. http://dx.doi.org/10.16925/2357-6014.2022.03.11.
Abstract: This article reviews the literature on the latest advances in microdevices for medical applications. The objective is to show an overview of the latest devices and their applications, as well as future development vectors in the area. A search of about 170 articles was performed, most of them published between the years 2015 and 2021, of which 53 were chosen as they were the most topical and impactful in the research fields referred to drug delivery, minimally invasive surgery, and cranial and vascular intromissions. It is concluded that, although microdevices are at an advanced stage of research, they still have many challenges to be solved, which has not allowed clinical trials to be completed in many cases. One of the great challenges ahead is to increase the precision in locomotion and to make the devices capable of performing more complex tasks with the help of smaller-scale electronic devices.
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Elman, NM, Y. Patta, AW Scott, B. Masi, HL Ho Duc, and MJ Cima. "The Next Generation of Drug-Delivery Microdevices." Clinical Pharmacology & Therapeutics 85, no. 5 (February 25, 2009): 544–47. http://dx.doi.org/10.1038/clpt.2009.4.
Tuncer, Mustafa, Feray Bakan, Hasan Gocmez, and Emre Erdem. "Capacitive behaviour of nanocrystalline octacalcium phosphate (OCP) (Ca8H2(PO4)6·5H2O) as an electrode material for supercapacitors: biosupercaps." Nanoscale 11, no. 39 (2019): 18375–81. http://dx.doi.org/10.1039/c9nr07108c.
Li, Wen, and Zhen Qiu. "Editorial for the Special Issue on Implantable Microdevices." Micromachines 10, no. 9 (September 12, 2019): 603. http://dx.doi.org/10.3390/mi10090603.
Implantable microdevices, providing accurate measurement of target analytes in animals and humans, have always been important in biological science, medical diagnostics, clinical therapy, and personal healthcare [...]
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Belaala, Abir, Zeina Al Masry, Labib Sadek Terrissa, and Noureddine Zerhouni. "Retargeting PHM tools: from industrial to medical field." PHM Society European Conference 5, no. 1 (July 22, 2020): 7. http://dx.doi.org/10.36001/phme.2020.v5i1.1232.
Prognostics and Health Management (PHM) approach, and theoretical models have had great success for industrial systems. Therefore, this accomplishment motivates us to think about potential extension of the PHM approach in such area as the medicine. The aim of this paper is to apply an adaptation of a PHM model from fault diagnosis of aircraft engine to diagnosis human heart disease. For that adaptation, an algorithm for retargeting extreme learning machine (ID-RELM) is applied. The complete process from data pre-processing to classification is developed. Numerical results using heart disease benchmark dataset showed that the combination of random forest and ID-RELM provides the highest classification accuracy and outperforms other algorithms in classifying this chronic disease status.
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Metzger, J. M., and R. H. Fitts. "Role of intracellular pH in muscle fatigue." Journal of Applied Physiology 62, no. 4 (April 1, 1987): 1392–97. http://dx.doi.org/10.1152/jappl.1987.62.4.1392.
Intracellular pH of in vitro diaphragm preparations was determined following low- (5 Hz, 1.5 min) and high- (75 Hz, 1 min) frequency stimulation, using glass microelectrodes of the liquid membrane type (pHm). Results were compared with values obtained by the standard homogenate technique (pHh). High- and low-frequency stimulation reduced peak tetanic tension to 21 +/- 1 (SE) and 71 +/- 2% of initial values, respectively. Peak tetanic tension returned to resting values after 10- to 15-min recovery from high- or low-frequency stimulation. Resting pHm was 7.063 +/- 0.011 (n = 72), and after fatiguing stimulation declined to values as low as 6.33. During recovery pHm significantly increased and by 10 min had returned to prefatigue values. No difference was observed in the recovery of pHm between the low- and high-frequency stimulation groups (analysis of variance test, ANOVA), and in both groups pHm recovery was highly correlated to the recovery of peak tetanic tension (r = 0.94, P less than 0.001). Resting pHh was 7.219 +/- 0.023 (n = 13), which was significantly higher than the pHm value. In contrast to pHm, intracellular pHh was significantly higher during recovery from 75- vs. 5-Hz stimulation (P less than 0.05). For both groups pHh increased significantly with time and by 10 min returned to prestimulation values. The ANOVA test demonstrated that pHh values were significantly higher than pHm values during recovery from fatigue. The results from this study support our hypothesis that fatigue from both high- and low-frequency stimulation is at least partially due to the deleterious effects of intracellular acidosis on excitation-contraction coupling.
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Spriet, L. L., K. Soderlund, M. Bergstrom, and E. Hultman. "Skeletal muscle glycogenolysis, glycolysis, and pH during electrical stimulation in men." Journal of Applied Physiology 62, no. 2 (February 1, 1987): 616–21. http://dx.doi.org/10.1152/jappl.1987.62.2.616.
Glycogenolytic and glycolytic rates were estimated and muscle pH (pHm) was measured in electrically stimulated quadriceps femoris muscles of seven men. Leg blood flow was occluded and muscles were stimulated 64 times at 20 Hz, with contractions lasting 1.6 s and separated by pauses of 1.6 s. Muscle biopsies were obtained at rest and following 16, 32, 48, and 64 contractions. Glycolytic intermediates and several modulators of the glycolytic enzyme phosphofructokinase (PFK) were measured. Glycogenolytic and glycolytic rates were 1.68 and 1.26 mmol glucosyl units X kg dry muscle-1 X S-1 contraction time during the initial 16 contractions and pHm decreased from 7.00 +/- 0.01 to 6.70 +/- 0.03. During the subsequent 32 contractions both glycogenolytic and glycolytic rates were maintained at approximately 0.70 mmol X kg-1 X S-1 and pHm decreased to 6.45 +/- 0.04. In the final 16 contractions, both rates were very low and pHm was unchanged. Therefore, PFK remained active despite increasing acidity until pHm decreased to approximately 6.45. We conclude that increases in the concentrations of several positive modulators partially reverses pH-dependent ATP inhibition of PFK in vivo, permitting glycolytic activity to continue in the pHm range of 6.70–6.45.
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Sharma, Suresh D., Gayatri Raghuraman, Myeong-Seon Lee, Nanduri R. Prabhakar та Ganesh K. Kumar. "Intermittent hypoxia activates peptidylglycine α-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing". Journal of Applied Physiology 106, № 1 (січень 2009): 12–19. http://dx.doi.org/10.1152/japplphysiol.90702.2008.
Intermittent hypoxia (IH) associated with sleep apneas leads to cardiorespiratory abnormalities that may involve altered neuropeptide signaling. The effects of IH on neuropeptide synthesis have not been investigated. Peptidylglycine α-amidating monooxygenase (PAM; EC 1.14.17.3) catalyzes the α-amidation of neuropeptides, which confers biological activity to a large number of neuropeptides. PAM consists of O2-sensitive peptidylglycine α-hydroxylating monooxygenase (PHM) and peptidyl-α-hydroxyglycine α-amidating lyase (PAL) activities. Here, we examined whether IH alters neuropeptide synthesis by affecting PAM activity and, if so, by what mechanisms. Experiments were performed on the brain stem of adult male rats exposed to IH (5% O2for 15 s followed by 21% O2for 5 min; 8 h/day for up to 10 days) or continuous hypoxia (0.4 atm for 10 days). Analysis of brain stem extracts showed that IH, but not continuous hypoxia, increased PHM, but not PAL, activity of PAM and that the increase of PHM activity was associated with a concomitant elevation in the levels of α-amidated forms of substance P and neuropeptide Y. IH increased the relative abundance of 42- and 35-kDa forms of PHM (∼1.6- and 2.7-fold, respectively), suggesting enhanced proteolytic processing of PHM, which appears to be mediated by an IH-induced increase of endoprotease activity. Kinetic analysis showed that IH increases Vmaxbut has no effect on Km. IH increased generation of reactive oxygen species in the brain stem, and systemic administration of antioxidant prevented IH-evoked increases of PHM activity, proteolytic processing of PHM, endoprotease activity, and elevations in substance P and neuropeptide Y amide levels. Taken together, these results demonstrate that IH activates PHM in rat brain stem via reactive oxygen species-dependent posttranslational proteolytic processing and further suggest that PAM activation may contribute to IH-mediated peptidergic neurotransmission in rat brain stem.
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Spriet, L. L., K. Soderlund, J. A. Thomson, and E. Hultman. "pH measurement in human skeletal muscle samples: effect of phosphagen hydrolysis." Journal of Applied Physiology 61, no. 5 (November 1, 1986): 1949–54. http://dx.doi.org/10.1152/jappl.1986.61.5.1949.
Measurements of muscle pH (pHm) with the homogenate technique are routinely made when extensive phosphagen hydrolysis has occurred. Upon exposure of the homogenate to 37 degrees C in the pH meter, phosphocreatine and ATP were rapidly degraded to 35 and 60% of control concentrations after 30 s. Attempts at chemically arresting this hydrolysis were unsuccessful. Therefore we examined the significance of phosphagen hydrolysis on pHm measurement in human biopsies taken at rest and following intense electrical stimulation. To accomplish this, pHm was measured at 0 degree C, where extensive hydrolysis did not occur. On the same homogenate, pHm was measured at 0 degree C with phosphagens and at 0 and 37 degrees C after phosphagen hydrolysis. The effect of phosphagen hydrolysis on pHm at 0 degrees C was used to estimate this effect at 37 degrees C. In resting samples, phosphagen hydrolysis produced a nonsignificant acidification of 0.008 pH units and, in electrically stimulated samples, a nonsignificant alkalinization of 0.033 units. Measurements of homogenate PCO2 suggested that most of the CO2 remained in the sample during pHm measurement at 37 degrees C. The present work substantiates the use of the homogenate technique as an accurate and practical method for the estimation of intracellular pH in resting and exercise human muscle samples.
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Granger, Carl V., Marsha Carlin, Pedro Diaz, Jane Dorval, Steve Forer, Corby Kessler, John L. Melvin, Lawrence S. Miller, Richard V. Riggs, and Pamela Roberts. "Medical Necessity." American Journal of Physical Medicine & Rehabilitation 88, no. 9 (September 2009): 755–65. http://dx.doi.org/10.1097/phm.0b013e3181aa71a8.
Vastesson, Alexander. "Thiol-ene and Thiol-ene-epoxy Based Polymers for Biomedical Microdevices." Doctoral thesis, KTH, Mikro- och nanosystemteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215110.
Within healthcare there is a market pull for biomedical devices that can rapidly perform laboratory processes, such as diagnostic testing, in a hand-held format. For this reason, biomedical devices must become smaller, more sophisticated, and easier to use for a reasonable cost. However, despite the accelerating academic research on biomedical microdevices, and especially plastic-based microfluidic chips, there is still a gap between the inventions in academia and their benefit to society. To bridge this gap there is a need for new materials which both exhibit similar properties as industrial thermoplastics, and that enable rapid prototyping in academia. In this thesis, thiol-ene and thiol-ene-epoxy thermosets are evaluated both in terms of their suitability for rapid prototyping of biomedical microdevices and their potential for industrial manufacturing of “lab-on-chips”. The first part of the thesis focuses on material development of thiol-ene and thiol-ene-epoxy thermosets. Chemical and mechanical properties are studied, as well as in vitro biocompatibility with cells. The second part of the thesis focuses on microfabrication methods for both thermosets. This includes reaction injection molding, photostructuring, and surface modification. It is demonstrated how thiol-ene and thiol-ene-epoxy both provide advantageous thermo-mechanical properties and versatile surface modifications via “thiol-click chemistry”. In the end of the thesis, two applications for both polymer platforms are demonstrated. Firstly, thiol-ene is used for constructing nanoliter well arrays for liquid storage and on-demand electrochemical release. Secondly, thiol-ene-epoxy is used to enhance the biocompatibility of neural probes by tuning their flexibility. It is concluded that both thiol-ene and thiol-ene-epoxy thermosets exhibit several properties that are highly suitable for rapid prototyping as well as for scalable manufacturing of biomedical microdevices.
QC 20171003
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Griss, Patrick. "Micromachined Interfaces for Medical and Biochemical Applications." Doctoral thesis, KTH, Signals, Sensors and Systems, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3353.
Mittelstadt, Brent. "On the ethical implications of personal health monitoring." Thesis, De Montfort University, 2013. http://hdl.handle.net/2086/10101.
Recent years have seen an influx of medical technologies capable of remotely monitoring the health and behaviours of individuals to detect, manage and prevent health problems. Known collectively as personal health monitoring (PHM), these systems are intended to supplement medical care with health monitoring outside traditional care environments such as hospitals, ranging in complexity from mobile devices to complex networks of sensors measuring physiological parameters and behaviours. This research project assesses the potential ethical implications of PHM as an emerging medical technology, amenable to anticipatory action intended to prevent or mitigate problematic ethical issues in the future. PHM fundamentally changes how medical care can be delivered: patients can be monitored and consulted at a distance, eliminating opportunities for face-to-face actions and potentially undermining the importance of social, emotional and psychological aspects of medical care. The norms evident in this movement may clash with existing standards of 'good' medical practice from the perspective of patients, clinicians and institutions. By relating utilitarianism, virtue ethics and theories of surveillance to Habermas' concept of colonisation of the lifeworld, a conceptual framework is created which can explain how PHM may be allowed to change medicine as a practice in an ethically problematic way. The framework relates the inhibition of virtuous behaviour among practitioners of medicine, understood as a moral practice, to the movement in medicine towards remote monitoring. To assess the explanatory power of the conceptual framework and expand its borders, a qualitative interview empirical study with potential users of PHM in England is carried out. Recognising that the inherent uncertainty of the future undermines the validity of empirical research, a novel epistemological framework based in Habermas' discourse ethics is created to justify the empirical study. By developing Habermas' concept of translation into a procedure for assessing the credibility of uncertain normative claims about the future, a novel methodology for empirical ethical assessment of emerging technologies is created and tested. Various methods of analysis are employed, including review of academic discourses, empirical and theoretical analyses of the moral potential of PHM. Recommendations are made concerning ethical issues in the deployment and design of PHM systems, analysis and application of PHM data, and the shortcomings of existing research and protection mechanisms in responding to potential ethical implications of the technology.
Книги з теми "PHM for medical microdevices":
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Saliterman, Steven. Fundamentals of bioMEMS and medical microdevices. [Hoboken, NJ]: Wiley-Interscience, 2006.
Netherlands) Personal Health Monitoring (PHM) and Ethics (Symposium) (2012 Rotterdam. Interdisciplinary assessment of personal health monitoring. Amsterdam: IOS Press, 2013.
SPIE, Manuel Delgado-Restituto, Angeliki Tserepi, and Eleni Makarona. Bio-MEMS and Medical Microdevices: 25-26 April 2013, Grenoble, France. SPIE, 2013.
Частини книг з теми "PHM for medical microdevices":
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Zahn, Jeffrey D. "Integrated Microdevices for Medical Diagnostics." In Encyclopedia of Microfluidics and Nanofluidics, 1411–18. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_709.
Zahn, Jeffrey D. "Integrated Microdevices for Medical Diagnostics." In Encyclopedia of Microfluidics and Nanofluidics, 1–8. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-3-642-27758-0_709-2.
Тези доповідей конференцій з теми "PHM for medical microdevices":
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Saracaydin, Renc, and Seth A. Hara. "Additive Manufacturing of Medical Microdevices." In 2022 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/dmd2022-1042.
Abstract Additive manufacturing is a growing field, but its application in the fabrication of medical microdevices has not been fully explored. Traditionally, medical microdevices are manufactured via a combination of techniques such as photolithography, laser-cutting, and micromolding, which collectively have challenges such as multiple fabrication steps, limited design freedom, high fabrication cost, and significant fabrication time. Micro vat photopolymerization is presented here as an alternative method to produce four different microscale medical devices that have applications in microfluidics, drug delivery, and bioscaffolding. In terms of minimum feature size and resolution, the presented structures are comparable, if not superior, to literature quoted parts fabricated through conventional manufacturing methods. The fabrication steps, process parameters, design considerations, learnings, and future research directions are outlined.
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Akira Yamada, Fuminori Niikura, and Koji Ikuta. "Fabrication of biodegradable microdevices toward medical application." In 2007 IEEE/ASME international conference on advanced intelligent mechatronics. IEEE, 2007. http://dx.doi.org/10.1109/aim.2007.4412573.
Gray, Bonnie Lynne. "Active polymers for bio medical microdevices and microfluidic systems." In 2016 IEEE 34th VLSI Test Symposium (VTS). IEEE, 2016. http://dx.doi.org/10.1109/vts.2016.7477270.
Pouponneau, Pierre, L'Hocine Yahia, Yahye Merhi, Laura Mery Epure, and Sylvain Martel. "Biocompatibility of Candidate Materials for the Realization of Medical Microdevices." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.260061.
Pouponneau, Pierre, L'Hocine Yahia, Yahye Merhi, Laura Mery Epure, and Sylvain Martel. "Biocompatibility of Candidate Materials for the Realization of Medical Microdevices." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.4397918.
Jonušauskas, Linas, Dovile Andrijec, Tomas Baravykas, Agne Butkute, Titas Tičkūnas, Tomas Gadišauskas, and Vytautas Purlys. "Hybrid additive-subtractive femtosecond laser 3D fabrication of medical microdevices (Conference Presentation)." In Laser 3D Manufacturing VII, edited by Henry Helvajian, Bo Gu, and Hongqiang Chen. SPIE, 2020. http://dx.doi.org/10.1117/12.2544578.
Xi, Jianzhong, Jacob Schmidt, and Carlo Montemagno. "Self-Assembled Silicon Microdevices Driven by Muscle." In ASME 2004 3rd Integrated Nanosystems Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/nano2004-46075.
Over the last two decades, a variety of micro-robotic systems have been developed including electrothermal, electrostatic, electrochemical, piezoelectric, and electromagnetic actuators based on MEMS technology. The development of these micro-actuators promises a revolution in biological and medical research and applications analogous to that brought about by the miniaturization of electrical devices in information technology. For example, controllable manipulation of these tiny actuators may enable precise temporal and spatial delivery of chemicals, micro-optics or microelectronics to specific targeted sites.
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Kirillov, Sergey, Aleksandr Kirillov, Vitalii Iakimkin, Alexander Khodos, Yuri Kaganovich, and Michael Pecht. "PHM applications in medicine and medical implantable device." In 2016 Prognostics and System Health Management Conference (PHM-Chengdu). IEEE, 2016. http://dx.doi.org/10.1109/phm.2016.7819755.
Hareland, Scott A., and Leonard P. Radtke. "Prognostic opportunities and limitations in implantable medical devices." In 2013 IEEE Conference on Prognostics and Health Management (PHM). IEEE, 2013. http://dx.doi.org/10.1109/icphm.2013.6621412.
Yamada, Akira, Fuminori Niikura, and Koji Ikuta. "Three-Dimensional Microfabrication System for Biodegradable Microdevices With High-Resolution and Bio-Applicability." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-82154.
Biodegradable polymers are employed in medicine and its further application is expected with eagerness. But the lack of an appropriate processing method retards the progress. To overcome this problem, we have developped a novel three-dimensional microfabrication system. The system design allows us the processing of the free three-dimensional micro-level forms by stacking up melted polymers from the nozzle. Different from the conventional method, we adopted a batch process to supply materials in order to eliminate the prior process that required toxic solvents. In addition, it is possible to handle almost all biodegradable thermoplastic resins by adopting this system. A single layer from the piled-up layers of extruded lines was observed to evaluate the resolution. The lateral and depth resolutions attained are 40 μm and 45 μm, respectively. Biodegradable polymers enable three-dimensional microstructures such as micro-pipes, micro-bends, and micro-coil springs to be manufactured in less than 15 min. The biocompatibility of the newly fabricated structure was evaluated using a cell line (PC12). For this purpose, a small vessel, with a transparent base, was fabricated using PLA and cells were cultivated in it. The results were then compared with the results obtained using the standard method. The mechanical strength of our microstructures was evaluated using a tensile strength test. The tensile strength of the microstructure was lower than the one obtained from the conventional method, but has enough strength for fabrication of medical devices. Our system renders it possible to produce toxic-free, as well as transparent and leakage-free devices. Our system is expected to have potential applications in optimum design and fabrication of implantable devices, especially in tissue engineering.
