Добірка наукової літератури з теми "Phenyl-derivative"
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Статті в журналах з теми "Phenyl-derivative"
Collins, David J., Timothy C. Hughes, and Wynona M. Johnson. "Dihydro-1,2,4-triazin-6(1H)-ones. III. Oxidation Products of 1-Methyl-3-phenyl- 4,5-dihydro-1,2,4-triazin-6(1H)-one." Australian Journal of Chemistry 52, no. 10 (1999): 971. http://dx.doi.org/10.1071/ch99047.
Повний текст джерелаNardis, Sara, Daniel O. Cicero, Silvia Licoccia, Giuseppe Pomarico, Beatrice Berionni Berna, Marco Sette, Giampaolo Ricciardi, et al. "Phenyl Derivative of Iron 5,10,15-Tritolylcorrole." Inorganic Chemistry 53, no. 8 (April 3, 2014): 4215–27. http://dx.doi.org/10.1021/ic5003572.
Повний текст джерелаSaxena, N., S. Kumar, M. K. Sharma, and S. P. Mathur. "Corrosion Inhibition of Mild Steel in Nitric Acid Media by some Schiff Bases Derived from Anisalidine." Polish Journal of Chemical Technology 15, no. 1 (March 1, 2013): 61–67. http://dx.doi.org/10.2478/pjct-2013-0011.
Повний текст джерелаKrečmerová, Marcela, Hubert Hřebabecký, Milena Masojídková, and Antonín Holý. "Synthesis of 5-Phenyl-2(1H)-pyrimidinone Nucleosides." Collection of Czechoslovak Chemical Communications 61, no. 3 (1996): 458–77. http://dx.doi.org/10.1135/cccc19960458.
Повний текст джерелаZhang, Yu-yang, Jian-Ting Pan, and Jian-Yan Huang. "4-{Phenyl[4-(6-phenyl-2,2′-bipyridin-4-yl)phenyl]amino}benzaldehyde." Acta Crystallographica Section E Structure Reports Online 70, no. 8 (July 2, 2014): o840. http://dx.doi.org/10.1107/s1600536814013361.
Повний текст джерелаBöhm, Stanislav, Richard Kubík, Martin Hradilek, Jan Němeček, Michal Hušák, Bohumil Kratochvíl, and Josef Kuthan. "Sterically Crowded Heterocycles. II. Conformational Structure of 2-Phenyl-3-[(Z)-1,3-diphenyl-3-oxopropenyl]imidazo[1,2-a]pyridine and Related Compounds." Collection of Czechoslovak Chemical Communications 60, no. 1 (1995): 115–26. http://dx.doi.org/10.1135/cccc19950115.
Повний текст джерелаKonečný, Václav, Jozefína Žúžiová, Štefan Kováč, and Tibor Liptaj. "Synthesis of Novel 4-Amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones." Collection of Czechoslovak Chemical Communications 62, no. 5 (1997): 800–808. http://dx.doi.org/10.1135/cccc19970800.
Повний текст джерелаMistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione,para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 30–41. http://dx.doi.org/10.1155/2005/953107.
Повний текст джерелаKhalifa, Nagy M., Ahmed M. Naglah, Mohamed A. Al-Omara, and Abd El-Galil E. Amr. "Synthesis and Reactions of New Chiral Linear Dipeptide Candidates Using Nalidixic Acid as Starting Material." Zeitschrift für Naturforschung B 69, no. 6 (June 1, 2014): 728–36. http://dx.doi.org/10.5560/znb.2014-4031.
Повний текст джерелаErdem, Ahmet, Hasan Genc, Nejdet Sen, Rafet Kilincarslan, and Emin Erdem. "The Synthesis and Reactions of Novel Pyrazole Derivatives by 4-phenylcarbonyl-5-phenyl-2,3-dihydro-2,3-furandione Reacted with Some Hydrazones." Revista de Chimie 68, no. 1 (February 15, 2017): 143–46. http://dx.doi.org/10.37358/rc.17.1.5407.
Повний текст джерелаДисертації з теми "Phenyl-derivative"
Chen, Yu-Chen, and 陳于真. "The Effect of Admantane Derivative: 2, 2-bis [4- (4-amino-3-hydroxyphenoxy) phenyl] adamantane on Colon Cancer Cells." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/13517168515691465009.
Повний текст джерела國立陽明大學
藥理學研究所
92
Abstract Previously, the admantane derivative 2, 2-bis [4- (4-amino-3-hydroxyphenoxy) phenyl] adamantane (DPA) demonstrated marked anticancer activities on the sub-panel of 60 human cancer cell lines in NCI Anticancer Drug Screen System. Consequently, DPA was selected as a candidate for further examination. The objective of this study was to examine the in vitro and in vivo effects and the action mechanism of DPA on colon cancer cells. Results showed that DPA exerted inhibitory activities in vitro against three human colon cancer cell lines Colo 205, HT-29, and HCT-15 in a dose- and time-dependent manner. DPA-treated cells were arrested at G0/G1 phase as analyzed by flowcytometric analysis. After 2, 4, and 8 μM DPA treatment for 72 hours, the level of the differentiation makers fibronectin and carcinoembryonic antigen were increased. The in vivo effect of DPA on tumor growth suppression using BALB/c-nu mouse xenografts of Colo 205 cells showed that DPA significantly inhibited the growth of Colo 205 without any evidence of drug toxicity at 80 mg/kg once a week. DPA-treated Colo 205 cells showed compact aggregate formation and tight junction between cells. E-cadherin-catenin complex has an important role in contact inhibition of the growth in normal epithelial cells by activation of p27 and inducing cell cycle arrest. It was observed that Colo 205 cells were more sensitive to DPA than HT-29 and HCT-15 cells. Therefore, Colo 205 cells were used for further examination of DPA’s action mechanism. Immunoflourescence and Western blotting analyses showed that after 4 □M DPA treatment for 24 hr, E-cadherin translocated to cell membrane and the expression of dephosphorylated form of p120ctn increased concomitantly. In contrast, the level of p27 increased at 48 hr. On the other hand, the expression of p21 was induced after DPA treatment in a p53-independent manner. These results together suggest that the effect of DPA on Colo 205 may be through the induction of p21 and the increased level of p27 after the activation of E-cadherin-catenin complex.
Krishnapriya, K. C. "Role of spin density and interchromophoric coupling in singlet fission." Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5735.
Повний текст джерелаTang, Zhi-Hsung, and 湯智翔. "The effect of admantane derivative, 2,2-Bis(4-(4-amino-3-hydroxyphenoxy)phenyl)adamantane (DPA), on the metastasis of HCT116 colorectal cancer cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/41849352303969793829.
Повний текст джерела國立陽明大學
藥理學研究所
100
Colorectal cancer (CRC) is one of the most common cancers in the world. In the statistics of 2009 published by Department of Health, Executive Yuan, R.O.C. (Taiwan) showed that colorectal cancer has taken the first place of rate of increase in all kind of cancers. Liver metastasis is frequently found in CRC patients and the prognosis is the worst, and the usual treatments are surgery and/or chemotherapies. Surgery is the main treatment of CRC. Chemotherapies are used for the adjuvant treatment of inoperable patients with excision of the lesion and reduce the relapse rate. However, some patients have severe side effects such as nausea, vomiting, decreased immune function after received 5-FU-based chemotherapies, and the choice of drugs for chemotherapies still has a few. Hence, finding a new chemotherapeutic drug with fewer side effects is urgently needed. Adamantane is a kind of compound found in the petroleum. Its related derivatives have been developed in many clinical uses, such as antiviral, neuroprotective, anti-inflammatory, anti-microbial, anti-HIV activities. For anti-cancer activities investigation, the derivativesof adamantine can result in cell apoptosis and growth inhibition to breast cancer, ovarian cancer, and colorectal cancer. Our laboratory have reported the anti-colorectal cancer activity of the rest of compounds: 1,6-Bis[4- (4-amino-3-hydroxyphenoxy)phenyl]diamantine (DPD), N-1- (3,5-dimethyladamantyl)maleimide (DMAMI), and 2,2-Bis(4-(4-amino- 3-hydroxyphenoxy)phenyl)adamantane (DPA). About the previous results of 2,2-Bis(4- (4-amino-3-hydroxyphenoxy)phenyl)adamantine (DPA), it is found to have growth inhibition ability in previous studies. DPA also induces CRC cell cycle arrest in G0/G1 phase, and elevate negative cell cycle regulatory proteins (p21, p27) expression. In addition, it can promote differentiation of CRC cells and increase intercellular adhesion with no acute toxicity in animal model. Furthermore, DPA can be combined with CPT-11 and increase CRT-11 anti-cancer activity. The aim of this study was to investigate whether DPA could inhibit metastasis of CRC cells. SRB assay results showed that DPA time-dependently inhibited the growth of HCT116 cells. In wound healing assay, the inhibition of HCT116 cells migration was observed. Furthermore, 2 to 4 μM DPA treatment for 48 hours also inhibited the migration HCT116 cells in transwell assay. The animal liver metastasis model showed that tumor generation of SCID mice under 40mg/kg DPA twice a week treatment for 4 weeks is less than mice given only once DPA treatment. Besides, preliminary findings showed that DPA could suppress mTOR expression after 48 hours 4 μM DPA treatment, then decrease downstream metastasis related protein, Twist expression, and finally raise E-cadherin expression. In conclusion, the potential of inhibition of CRC metastasis through mTOR signaling pathway by DPA can be confirmed.
Частини книг з теми "Phenyl-derivative"
Brea, O., I. Alkorta, I. Corral, O. Mó, M. Yáñez, and J. Elguero. "Intramolecular Beryllium Bonds. Further Insights into Resonance Assistance Phenomena." In Intermolecular Interactions in Crystals: Fundamentals of Crystal Engineering, 530–58. The Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/bk9781782621737-00530.
Повний текст джерелаТези доповідей конференцій з теми "Phenyl-derivative"
Yanagisawa, M., M. Kunimoto, and T. Homma. "Depth Profile Analysis of Chemical Structures Around Lubricant/Overcoat Interface Using Plasmonic Sensor." In ASME 2016 Conference on Information Storage and Processing Systems. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/isps2016-9514.
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