Дисертації з теми "Pharmacokinetics"
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Chigutsa, Emmanuel. "Population pharmacokinetics and pharmacokinetic-pharmacodyamic modeling of antitubercular drugs." Doctoral thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3275.
Повний текст джерелаIncludes bibliographical references.
The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in 78 patients with tuberculosis were described using non-linear mixed effects modeling. Pharmacodynamic data was comprised of weekly sputum liquid culture (using mycobacterial growth indicator tubes) time to detection results from 144 patients during the first 2 months of treatment. The effect of drug exposure on patient outcomes was investigated. To determine the adequacy of ofloxacin drug exposure, the probability of attaining the required area-under-the-curve to minimum inhibitory concentration ratio (AUC/MIC) of ofloxacin was determined in 65 patients on treatment for multidrug resistant tuberculosis. To improve efficiency in the clinical development of new drug regimens, clinical trial simulation was used to determine the optimal study design for a study investigating the efficacy of a new antitubercular drug regimen. The SLCO1B1 rs4149032 polymorphism existed at a high frequency of 0.70 in South Africans and resulted in a 28% decrease in bioavailability of rifampicin. The rifampicin peak concentration was a significant predictor of the 2 month treatment outcomes. A semimechanistic time to event model was developed to analyze days to positivity (time to detection) data. The model was comprised of a biexponential decay model describing bacillary decline in sputum from patients, followed by a logistic model with a lag time for growth of the mycobacteria in liquid culture. For the current 800 mg daily dose of ofloxacin, the probability of attaining an AUC/MIC target ratio of at least 100 was only 0.45. Based on clinical trial simulation, the optimum parallel study design was comprised of 125 study participants in each of 2 arms to achieve a study power of at least 80%. Increasing the study length beyond 42 days reduced study power perhaps due to increased amounts of censored data. Higher doses of rifampicin are required in the majority of South African patients with tuberculosis. A novel pharmacodynamic model of tuberculosis treatment is presented, which can be used for investigation of covariates such as drug exposure. Ofloxacin should be replaced with a more potent fluoroquinolone for treatment of multidrug resistant tuberculosis. Clinical trials should not be unduly long otherwise this may compromise study power.
Ulrich-Oppliger, Brigitte Madeleine. "Pharmacokinetics /." Bern, 1992. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Повний текст джерелаCharter, Mark Keith. "Maximum entropy pharmacokinetics." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316691.
Повний текст джерелаSmith, Jennifer Lisa. "Pharmacokinetics of methylamines." Thesis, Massachusetts Institute of Technology, 1992. http://hdl.handle.net/1721.1/12906.
Повний текст джерелаKhosravan, Reza. "Nonlinear pharmacokinetics of diltiazem." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0030/NQ46865.pdf.
Повний текст джерелаAl-Mustafa, Z. H. "Methotrexate pharmacokinetics and toxicity." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383988.
Повний текст джерелаWoodhouse, Jennifer Ann. "Plutonium pharmacokinetics and blood biochemistry." Thesis, University of Central Lancashire, 1997. http://clok.uclan.ac.uk/20148/.
Повний текст джерелаSmith, Adam John. "Modulating the Pharmacokinetics of Bioflavonoids." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4226.
Повний текст джерелаHarper, Kenneth W. "Pharmacokinetics of methohexitone and midazolam." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254195.
Повний текст джерелаEvans, Gary Lee. "Pharmacokinetics and metabolism of lacidipine." Thesis, University of Hertfordshire, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387196.
Повний текст джерелаAhsan, Chowdhury Hafizul. "Pharmacokinetics of nifedipine in humans." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303154.
Повний текст джерелаRichards, Robert. "The pharmacokinetics of sodium cromoglycate." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359034.
Повний текст джерелаBester, Lynette. "Pharmacokinetics of propofol in cats." Diss., University of Pretoria, 2009. http://hdl.handle.net/2263/22954.
Повний текст джерелаDissertation (MMedVet)--University of Pretoria, 2009.
Companion Animal Clinical Studies
unrestricted
Tongaree, Sauwaluxana. "Vancomycin pharmacokinetics : development and assessment." Scholarly Commons, 1991. https://scholarlycommons.pacific.edu/uop_etds/2224.
Повний текст джерелаBester, Lynette. "Pharmacokinetics of propofol in cats." Pretoria : [s.n.], 2021. http://upetd.up.ac.za/thesis/available/etd-03032010-184513/.
Повний текст джерелаDragula, Collen Elizabeth 1964. "A pharmacokinetic study of acrylamide and theophylline in rats." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276847.
Повний текст джерелаOlsén, Lena. "Drugs in horses : pharmacokinetics and pharmacodynamics /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200737.pdf.
Повний текст джерелаTärning, Joel. "Piperaquine : bioanalysis, drug metabolism and pharmacokinetics /." Göteborg: Institute of Neuroscience and Physiology, Dept. of Pharmacology, the Sahlgrenska Academy at Göteborg University, 2007. http://hdl.handle.net/2077/7196.
Повний текст джерелаSiccardi, Marco. "Genetic determinants of key antiretroviral pharmacokinetics." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569560.
Повний текст джерелаKhazal, Kamel F. "Chloramphenicol pharmacokinetics and metabolism in dogs /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487267024996335.
Повний текст джерелаSong, Di. "Bladder tissue pharmacokinetics of anticancer drugs /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487940308433249.
Повний текст джерелаArends, Rosalinda Helena Gerardus Petronella. "Pharmacokinetics and pharmacodynamics of opioid analgesics /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/7955.
Повний текст джерелаWright, Abra M. "Pharmacokinetics of pergolide in normal mares." Thesis, Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1548.
Повний текст джерелаEriksson, Tommy. "Pharmacokinetics of the enantionmers of thalidomide." Malmö : Lund : Malmö University Hospital ; Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/68945032.html.
Повний текст джерелаWalker, Roderick Bryan. "HPLC analysis and pharmacokinetics of cyclizine." Thesis, Rhodes University, 1995. http://hdl.handle.net/10962/d1003279.
Повний текст джерелаRigby, Justin Holbrook. "Pharmacokinetics of Dexamethasone Delivered via Iontophoresis." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3895.
Повний текст джерелаMethaneethorn, Janthima. "Population pharmacokinetics and pharmacodynamics of pyronaridine." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4876.
Повний текст джерелаPigatto, Maiara Cássia. "Modelagem PK/PD do efeito anticancerígeno do etoposídeo em ratos com tumor de walker-256 utilizando concentrações livres intratumorais determinaas por microdiálise." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/148189.
Повний текст джерелаObjective: The aim of this study was to describe the relationship between total plasma and free interstitial tumor etoposide (ETO) concentrations and the drug tumor growth inhibition observed in a Walker-256 (W256) tumor-bearing Wistar rat model using the pharmacokinetic/pharmacodynamic (PK/PD) modeling. Methods: The experiments with animals were approved by CEUA/UFRGS (protocol number 22302). Pharmacokinetic experiments were conducted to determine total plasma and free intratumoral concentrations in two regions of W256 solid tumor by microdialysis. After administration of ETO 10 or 20 mg/kg i.v. bolus to W256 tumorbearing Wistar rats, blood and tissue microdialysate samples from tumor center and periphery were simultaneously collected up to 7h to determine the tumor penetration factor. An analytical HPLC-UV method was developed and validated for quantification of ETO in plasma and microdialysate samples. The pharmacodynamic experiments were conducted in W256 tumor-bearing rats that received ETO 5 or 10 mg/kg i.v. bolus every day for 8 and 4 days, respectively. Tumor volumes were monitored daily for 30 days. Non-compartmental analysis of PK data was performed in WinNonlin®. The PK and PK/PD modeling by population approach were performed using Monolix®. PK/PD data were analyzed using a modification of Simeoni TGI model by introducing an Emax function to describe the nonlinear relationship between tumor and plasma concentrations and effect. Results and Discussion: The HLPCUV method was developed and validated to determine plasma and tissue samples of ETO. ETO tumor penetration was higher in the tumor periphery (61 ± 15 % and 61 ± 29 %) than center (34 ± 6 % and 28 ± 11 %) following 10 and 20 mg/kg doses, respectively (ANOVA, α = 0.05). A 4-compartment structural model comprising a saturable distribution (Michaelis-Menten kinetics) into the tumor compartments from the central compartment simultaneously described the ETO concentration–time profiles in plasma and both tumor regions. The PK/PD population Simeoni TGI–Emax model was capable of describing the schedule-dependent antitumor effects of ETO using total plasma or free tumor concentrations obtained in a W256-tumor bearing Wistar rat model, resulting in higher k2max (maximal potency) for free concentrations (25.8 mL.μg-1.day-1 - intratumoral vs. 12.6 mL.μg-1.day-1 total plasma). Conclusions: The results showed that the use of free intratumoral drug concentrations in the PK/PD modeling can provide a better understanding of the pharmacokinetics and pharmacodynamics relationship and improve the forecasting ability of the models considering that the efficacy of antineoplastic drugs in the treatment of solid tumors is dependent on the drug ability to distribute into the tumor.
Reddingius, Wieb Reddingius Wiebrandus Gerardus. "Bioanalysis and pharmacokinetics of fumarates in humans /." [S.l.] : [s.n.], 1997. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12199.
Повний текст джерелаHu, Leijun. "Suramin pharmacokinetics after regional or systemic administration." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1114449390.
Повний текст джерелаHasegawa, Takaaki, Kenji Takagi, and Kiyoyuki Kitaichi. "Effects of Bacterial Endotoxin on Drug Pharmacokinetics." 名古屋大学医学部, 1999. http://hdl.handle.net/2237/6203.
Повний текст джерелаPenson, Richard Thomas. "The morphine glucuronides : pharmacokinetics, pharmacodynamics and interactions." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406201.
Повний текст джерелаPullen, Joyce. "Pharmacokinetics and dosing of antibiotics in neonates." [Maastricht] : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=8305.
Повний текст джерелаEkborn, Andreas. "Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-721-5.
Повний текст джерелаTurner, Joe. "Application of artificial neural networks in pharmacokinetics /." Connect to full text, 2003. http://setis.library.usyd.edu.au/adt/public_html/adt-NU/public/adt-NU20031007.090937/index.html.
Повний текст джерелаChan, Hui Min Ravis William R. "Pharmacokinetics of Voriconazole in horses and alpacas." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SPRING/Pharmacal_Sciences/Dissertation/Chan_Hui_20.pdf.
Повний текст джерелаRahman, Nargis Jahan. "Incorporation of population pharmacokinetics into drug development." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325239.
Повний текст джерелаKonsue, Nattaya. "Pharmacokinetics and chemopreventive potential of phenethyl isothiocyanate." Thesis, University of Surrey, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511107.
Повний текст джерела李富榮 and Foo-wing Lee. "Pharmacokinetics of homoharringtonine in Chinese leukemia patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31209233.
Повний текст джерелаDavies, Geraint Rhys. "Pharmacokinetics and pharmacodynamics of anti-tuberculosis chemotherapy." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502576.
Повний текст джерелаAl-Mehsen, Fahad A. "Clinical pharmacokinetics of antibiotics in cystic fibrosis." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336044.
Повний текст джерелаChen, An Ge. "The pharmacokinetics of imipramine in Chinese subjects." Thesis, Liverpool John Moores University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298148.
Повний текст джерелаLankford, William Timothy. "The toxicity and pharmacokinetics of pyrethroid microemulsions." Thesis, Nottingham Trent University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384861.
Повний текст джерелаKamali, F. "Metabolism and pharmacokinetics of paracetamol in man." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355292.
Повний текст джерелаChan, E. W.-Y. "Warfarin : Stereochemical aspects of pharmacokinetics and response." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374525.
Повний текст джерелаWattanatorn, Wiboon. "Pharmacokinetics of 5-fluorouracil in cancer patients." Thesis, Robert Gordon University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389482.
Повний текст джерелаCatterall, Fenton Scott. "The biological activity and pharmacokinetics of polyphenols." Thesis, University of Surrey, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365156.
Повний текст джерелаDevine, Elizabeth P. "Pharmacokinetics of intramuscular morphine in the horse." Kansas State University, 2012. http://hdl.handle.net/2097/13864.
Повний текст джерелаDepartment of Clinical Sciences
Warren L. Beard
Pharmacokinetics of Intramuscular Morphine in the Horse Elizabeth Devine, DVM; Butch KuKanich, DVM, PhD, DACVCP; Warren Beard, DVM, MS, DACVS Objective - To determine the pharmacokinetics of morphine after intramuscular administration in a clinical population of horses Design – Prospective, clinical study Animals – Pilot study included 2 normal horses and the clinical study included 75 horses Procedures – Morphine was administered at 0.1mg/kg, IM and 2-3 blood samples were obtained from each horse at various times from 0-9 hours after administration. Plasma morphine concentrations were measured using liquid chromatography and mass spectrometry. Results – Data was analyzed using a naïve pooled pharmacokinetic model. The half-life for the elimination phase was approximately 1.5 hours, the volume of distribution (per bioavailability) was approximately 4.5 L/kg and the clearance (per bioavailability) was approximately 35 mL/kg/min. The peak plasma concentration was 21.6 ng/mL and occurred approximately 4 minutes after administration. Plasma concentrations of morphine were below the limit of quantification by 7 hours in 74 horses. Conclusions and Clinical Relevance – The relatively short half-life of morphine indicates the need for frequent dosing to maintain targeted plasma concentrations. Adverse effects were uncommon in this study and morphine was well tolerated at a dose of 0.1 mg/kg, IM. Morphine may be a useful adjunctive therapy in painful horses, but the variable plasma concentrations suggest the dose and dosing interval may need to be adjusted to the individual patient’s response.
Merhar, Stephanie L. M. D. "Pharmacokinetics of levetiracetam in neonates with seizures." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1305030096.
Повний текст джерелаGordon, Bentley Horatio. "The pharmacokinetics and metabolism of almitrine bismesylate." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/34361.
Повний текст джерела