Дисертації з теми "Pharmaceutical processes"
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Scarr, James Richard Hadley. "Pharmaceutical development processes." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1446773/.
Повний текст джерелаHussain, M. S. H. "Magnesium stearate lubrication in pharmaceutical processes." Thesis, University of Bradford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233659.
Повний текст джерелаJohnson, David Benjamin. "Integrated design under uncertainty for pharmaceutical processes." Thesis, University College London (University of London), 2003. http://discovery.ucl.ac.uk/1383052/.
Повний текст джерелаRicard, Francois-Xavier. "Application of electrical resistance tomography to pharmaceutical processes." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417797.
Повний текст джерелаZolotariov, Eyal. "Modelling and optimisation of pharmaceutical formulations and processes." Thesis, King's College London (University of London), 2001. https://kclpure.kcl.ac.uk/portal/en/theses/modelling-and-optimisation-of-pharmaceutical-formulations-and-processes(0bc4835e-7920-4bca-9f87-f816770704ac).html.
Повний текст джерелаHAUSMAN-MANNING, DEBRA SUE. "APPLICATION OF PROCESS ANALYTICAL TECHNOLOGY TO PHARMACEUTICAL PROCESSES." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1108838053.
Повний текст джерелаMuller, Damian Christian. "Investigating the influences of validation on pharmaceutical manufacturing processes." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/566.
Повний текст джерелаBurke, Keeley. "The use of statistics in understanding pharmaceutical manufacturing processes." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3096.
Повний текст джерелаBeyer, Andreas [Verfasser], and Claudia [Akademischer Betreuer] Leopold. "Solid state transformations during pharmaceutical processes / Andreas Beyer ; Betreuer: Claudia Leopold." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/120967601X/34.
Повний текст джерелаTumuluri, Venkat S. "Quantitation of pharmaceutical formulations and monitoring of pharmaceutical processes using process analytical technology techniques : near infrared and Raman spectroscopy /." Full text available from ProQuest UM Digital Dissertations, 2007. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1414121171&SrchMode=1&sid=7&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1220637804&clientId=22256.
Повний текст джерелаFung, Ho Ki. "Synthesis and development of manufacturing processes for biopharmaceuticals /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIEN%202003%20FUNG.
Повний текст джерелаStewart, David, and Stacy D. Brown. "Active Learning Processes Used in US Colleges of Pharmacy." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/5296.
Повний текст джерелаWong, Chris Wai Leung. "Data integration for the monitoring of batch processes in the pharmaceutical industry." Thesis, University of Newcastle Upon Tyne, 2007. http://hdl.handle.net/10443/610.
Повний текст джерелаBell, Charlotte. "Advanced analytical and microbial methods for biopharmaceutical and pharmaceutical products and processes." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2736.
Повний текст джерелаBeyer, Andreas [Verfasser], and Claudia S. [Akademischer Betreuer] Leopold. "Solid state transformations during pharmaceutical processes / Andreas Beyer ; Betreuer: Claudia S. Leopold." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1194165087/34.
Повний текст джерелаStewart, David, Stacy D. Brown, Cheri W. Clavier, and Jarrett Wyatt. "Survey of Active Learning Processes Used in US Colleges of Pharmacy." Digital Commons @ East Tennessee State University, 2011. https://doi.org/10.5688/ajpe75468.
Повний текст джерелаWang, You-Gan. "Contributions to the theory of Gittins indices : with applications in pharmaceutical research and clinical trials." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293423.
Повний текст джерелаGIMENEZ, FLAVIA COSENTINO RAMOS. "PURCHASING AREA INTEGRATION ON MERGING AND ACQUISITION PROCESSES: CASE STUDY FROM THE PHARMACEUTICAL INDUSTRY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2014. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=28086@1.
Повний текст джерелаThe focus of this dissertation is on the good practices research and the critical success factors for merging and acquisition processes, used as basis for a critical analysis of the purchasing integration processes of two companies from the pharmaceutical sector. Since the birth of the first industries, this sector has had many historical negotiations in the merging and acquisitions processes. The paper describes and analyzes the main activities of purchasing and the technologies used by the acquiring company, which were defined as standards in integrating businesses. In order to have a throughout analysis, other complementary subjects were analyzed. They were of great importance for the overview of the integration process such as: motivational aspects used on merging companies, the functional detailing of the purchasing process and the supporting information technology. An analysis correlating the theory with real practices was done to verify their similarities. The conclusion took in consideration the merging processes review with suggestions for next studies and researches in the area.
Feng, Ruili. "Synthesis and evaluation of pharmaceutical and fine chemicals processes for intensification and sustainability benefits." Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/4125.
Повний текст джерелаChhatre, Sunil. "Evaluation of the financial and technical impacts of changing commercial-scale pharmaceutical manufacturing processes." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1445999/.
Повний текст джерелаKu, Shaari Ku Zilati. "Coating uniformity on a pharmaceutical tablet an experimental study and finite volume modeling of droplet impact behavior /." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5528.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains xv, 141 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 132-135).
Maclean, Aldritt Allister. "Comparison of two granulation processes with the view to reduce manufacturing cost." Thesis, Port Elizabeth Technikon, 2004. http://hdl.handle.net/10948/210.
Повний текст джерелаLuthra, Satinder Singh. "Membrane reactors for phase transfer catalytic processes : waste minimisation in the fine chemicals / pharmaceutical industry." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415167.
Повний текст джерелаXie, Xiangzhong [Verfasser], Ulrike [Akademischer Betreuer] Krewer, and Sebastian [Akademischer Betreuer] Sager. "Sensitivity Analysis and Robust Design of Pharmaceutical Manufacturing Processes / Xiangzhong Xie ; Ulrike Krewer, Sebastian Sager." Braunschweig : Technische Universität Braunschweig, 2020. http://d-nb.info/1215293674/34.
Повний текст джерелаWhite, Becky A. "The perceptions and beliefs of nurses using Knowledge Based Medication Administration (KBMA) bar code scanning processes in regards to patient safety." Thesis, Blessing-Rieman College of Nursing, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1598248.
Повний текст джерелаAccurate and safe medication administration is an important aspect in the everyday care of the hospitalized patient. Patients put their trust and safety into the hands of those providing care and expect that care is provided in a safe and efficient manner. Nurses strive to provide high quality error free, patient care. With adult patients, medication administration accounts for 26% to 32% of hospital medication errors (Koppel, Wetterneck, Telles, & Karsh, 2008). Only 2% of administration errors are corrected before reaching the patient (Dwibedi, et al., 2011). Literature supports that knowledge based medication administration programs reduce medication administration errors (Fowler, Sohler, & Zarillo, 2009). The research question proposed was: What are the perceptions and beliefs of nurses using Knowledge Based Medication Administration (KBMA) bar code scanning processes in regards to patient safety? The design was a quantitative, descriptive study, using a convenience sample. The study site was west-central Illinois hospital. Data were collected and analyzed related to the perceptions and beliefs of the staff nurses using KBMA in regards to patient safety during medication administration processes. Staff nurses were surveyed using a Likert-like scale. Participants accessed the survey via My Netlearning which linked to Survey Monkey. Participation was voluntary and responses were anonymous. Future implications for quality improvement and education are considered.
Naicker, Krishnaveni. "An investigation into the introduction of process analytical technology, using near infrared analysis, to selected pharmaceutical processes." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/577.
Повний текст джерелаRehder, Sönke Carsten [Verfasser], and Claudia Sabine [Akademischer Betreuer] Leopold. "Solid-state transformations induced by pharmaceutical processes during manufacturing / Sönke Carsten Rehder. Betreuer: Claudia Sabine Leopold." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2013. http://d-nb.info/1036729745/34.
Повний текст джерелаUnger, Alexandra M. "An analysis of differences in glass cartridge siliconization parameters and processes for manufacturing of pharmaceutical cartridges." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117961.
Повний текст джерелаThesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, in conjunction with the Leaders for Global Operations Program at MIT, 2018.
Some pages printed landscape. Cataloged from PDF version of thesis.
Includes bibliographical references (pages 82-84).
The application of silicone inside of glass insulin cartridges helps reduce injection forces during drug delivery. This is important for a less painful patient experience. Insulin pen designs are increasingly reliant on consistent and repeatable injection forces as mechanized injection replaces manual injection. A minimum silicone layer thickness of 40nm is required to produce low gliding forces of approximately two Newtons with little variability. Differences seen in final gliding forces across production areas at Sanofi Insulin Frankfurt are small, but this variation makes it difficult to design for set-force mechanical injection. While the minimum silicone layer thickness required is established, how to achieve it consistently is less understood. This project looked at three insulin packaging lines at Sanofi Insulin Frankfurt that use different methods for siliconization. Differences between these lines were investigated in order to understand which parameters are the most important for creating an acceptable silicone layer thickness. First, each production line was mapped from loading of empty cartridges through the end of the heating tunnel, before insulin is packaged. Differences in the process were found in cleaning procedures, silicone application methods, and production settings. Points for potential variability were found at silicone mixing steps and during start/stop conditions. Lab experiments were developed to test cleaning procedures, heating time, standing time, air pressure of silicone blowout, and silicone concentration. Results from these experiments showed that some production processes have a greater effect than others on silicone layer thickness and subsequent gliding forces. Differences in cleaning procedures on each of the lines have little effect on overall silicone layer thickness and gliding forces. Time in the heating tunnel and standing time have a moderate effect. The largest effects were seen from silicone emulsion concentration and air blow out pressures in the flushing method of silicone application. The following recommendations are given to improve performance consistency across production areas: (I) standardize processes across production areas where possible, (2) reduce air pressure in the flushing process, and (3) eliminate process steps that can lead to several of these effects occurring in the same cartridge.
by Alexandra M. Unger.
M.B.A.
S.M.
Al-Hasnawi, Hassan. "Solar Heat in Industrial Processes : Integration of Parabolic Trough Solar Collectors Dairy Plants and Pharmaceutical Plants." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125025.
Повний текст джерелаRehder, Sönke [Verfasser], and Claudia Sabine [Akademischer Betreuer] Leopold. "Solid-state transformations induced by pharmaceutical processes during manufacturing / Sönke Carsten Rehder. Betreuer: Claudia Sabine Leopold." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2013. http://d-nb.info/1036729745/34.
Повний текст джерелаSanderson, I. M. "The effect of formulation and maufacturing processes on the characterisitics of direct compression tablets." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372670.
Повний текст джерелаSiew, Weiming Eugene. "Application of membrane separation processes in the pharmaceutical industry : a study of process development for overcoming membrane limitations." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14348.
Повний текст джерелаAbu, Bakar Mohd R. "Process analytical technology based approaches for the monitoring and control of size and polymorphic form in pharmaceutical crystallisation processes." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/6436.
Повний текст джерелаBAYDUM, Valderice Pereira Alves. "Degradação de Propranolol em efluente modelo através de Processos Oxidativos." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/19024.
Повний текст джерелаMade available in DSpace on 2017-06-07T17:41:34Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) 2012-Tese-ValdereicePereiraBaydum.pdf: 1681832 bytes, checksum: b5c9d3beb02641d325fe71ba0c2037f2 (MD5) Previous issue date: 2012-11-23
A ocorrência de fármacos no meio ambiente tem se tornado um assunto de interesse nos últimos anos. Grande número desses compostos tem sido detectado em efluentes de estações de tratamento de esgoto (ETE) municipais, águas superficiais e, menos frequentemente, em águas subterrâneas e água potável em todo o mundo. Alguns dos efeitos adversos causados por fármacos incluem toxicidade aquática, desenvolvimento de resistência em bactérias patogênicas, genotoxicidade, e desregulação endócrina. Diferentes fontes podem ser indicadas para explicar o aparecimento de fármacos no ambiente aquático. Atualmente, é amplamente reconhecido que a principal fonte de poluição são os efluentes de ETE. Portanto, o descarte de resíduos farmacêuticos nos efluentes de ETE deve ser minimizado o máximo possível. A remoção de poluentes orgânicos recalcitrantes como fármacos na água e em efluentes pode ser obtida utilizando processos oxidativos avançados (POA). O objetivo deste trabalho é avaliar a eficiência de remoção de Propranolol por meio de POA, avaliar a toxicidade dos produtos de degradação durante os tratamentos bem como realizar um estudo cinético de degradação do composto. O fármaco usado neste estudo foi o Propranolol fornecido pelo LAFEPE. Foi utilizada solução modelo a 20 mgL-1 . Os tratamentos por meio de POA (H2O2/UV, Fenton e foto-Fenton) além de radiação UV (fotólise) e H2O2 foram realizados em escala laboratorial em um reator ao longo de 60 minutos. A radiação UV foi obtida por uma lâmpada a vapor de mercúrio de média pressão de 30 W. A agitação do sistema foi feita utilizando um agitador magnético. Sulfato ferroso heptahidratado foi utilizado como fonte de íons de ferro para o processo Fenton e foto-Fenton. A determinação e a quantificação do fármaco após tratamento por POA, foram realizadas em um espectrofotômetro UV-Vis. Em relação aos resultados obtidos pelo tratamento utilizando POA, o propranolol se mostrou pouco sensível a oxidação com peróxido de hidrogênio. O tratamento Foto-Fenton apresentou melhor eficiência de remoção e o Fenton o melhor resultado de toxicidade. A cinética de oxidação do fármaco foi discutida e verificou-se que o modelo cinético de pseudo-primeira ordem pode descrever melhor a oxidação do fármaco. As principais vantagens e desvantagens de cada processos e a complexidade de comparação dos vários processos de oxidação foram discutidos. O processo Foto-Fenton foi o que removeu mais de 80% do propranolol a 20 mg L-1 em 15 minutos.
The occurrence of pharmaceuticals in the environment has become a subject of interest in recent years. A vast number of these compounds have been detected in sewage treatment plant (STP) effluents, surface waters and, less frequently, in groundwater and drinking water, all over the world. Some of the adverse effects caused by pharmaceuticals include aquatic toxicity, resistance development in pathogenic bacteria, genotoxicity and endocrine disruption. Different sources can be indicated to explain the appearance of pharmaceuticals in the aquatic environment. Nowadays, it is widely accepted that the main source of pollution are STP effluents. Therefore, the discharge of pharmaceutical residues to the environment in STP effluents should be minimized. Removal of recalcitrant organic pollutants such as pharmaceuticals in water and wastewater can be achieved using advanced treatment technologies such as advanced oxidation processes (AOP). The objective of this study is to evaluate the removal efficiency of Propranolol by AOP to identify the degradation products toxicity as well as to perform a degradation kinetic study of these compounds. The pharmaceutical used in this study was Propranolol were purchased from LAFEPE. The pharmaceutical were spiked daily at a concentration of 20 mgL-1 were treated by AOP. The treatments by AOP (H2O2/UV, Fenton and photo-Fenton) and photolysis (UV radiation) and peroxide, were performed in a reactor along 60 minutes. UV radiation was provided by a medium pressure mercury lamp of 30 W. The agitation of the system was realized by a magnetic bar. Ferrous sulfate heptahydrate was used as source of iron for the Fenton and photo-Fenton process. The determination and quantification of the pharmaceutical present during the treatment by AOP were performed with UV-Vis spectrophotometer. With regard to the results obtained by using AOP treatment, the propranolol was less sensitive to hydrogen peroxide. Despite photo-fenton treatment presented the highest removal efficiency and Fenton the best treatment toxicity. The kinetics of oxidation of propranolol has been discussed and it was found that the pseudo-first order kinetic model can describe the oxidation. The main advantages and disadvantages of each process and the complexity of comparing the various advanced oxidation processes (AOP) was discussed. In the photo-fenton process it was possible to remove more than 80% from propranolol concentration of 20 mg L-1 in 15 minutes.
de, Caldeira Ricardo Luis Franco. "An assessment of cross-contamination issues in the context of chemical and pharmaceutical processes using a continuous oscillatory baffled reactor." Thesis, Heriot-Watt University, 2010. http://hdl.handle.net/10399/2381.
Повний текст джерелаPerra, Simone. "The study of Lovastatin production as a benchmark simulation model for bio-manufacturing processes." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
Знайти повний текст джерелаGünes, Ata, and Sarmiento Leonardo Arboleda. "What would middle managers do? A Case Study of a Culturally Shifting Global Pharmaceutical Company." Thesis, Jönköping University, Internationella Handelshögskolan, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-53064.
Повний текст джерелаSalgado, Ricardo Manuel Nunes. "The removal of xenobiotic compounds from wastewater through the use of biological processes and advanced oxidation technologies." Doctoral thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6918.
Повний текст джерелаFCT/MCTES projects PTDC/AMB/65702/2006 and SFRH/PROTEC/49449/2009 and SFRH/BPD/30800/2006 ; COST Action 636
Hancock, Bruno Caspar. "Material interactions and surface phenomena in size enlargement processes : an evaluation of the interactions occuring during the wet granulation of real and model pharmaceutical systems." Thesis, University of Bradford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262351.
Повний текст джерелаGlisovic, Tina. "The Multifunctional HnRNP A1 Protein in the Regulation of the Cyp2a5 Gene : Connecting Transcriptional and Posttranscriptional Processes." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3412.
Повний текст джерелаLe, Grevès Madeleine. "CNS Targets for GH and IGF-1 : Emphasis on Their Regulation in Relation to Cognitive Processes." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4758.
Повний текст джерелаThe interest for the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and its role in the central nervous system (CNS) has grown during the past decade. GH has been associated with psychological functions as sleep, mood, general well-being and learning and memory. The present thesis is a contribution to clarify the functions and mechanisms involved in the actions of GH and IGF-1 in the CNS. A variant of the GH receptor (GHR) gene transcript lacking exon 3 (GHR3-) was cloned from ovine choroid plexus epithelial cells and tissue. The GHR3- transcript has previously only been identified in human tissue. Further, an anatomical study of the localization of GHR mRNA in the rat brain stem and spinal cord was carried out by the use of in situ hybridization. High densities of GHRs were found in areas associated with the regulation of food intake, sleep and nociception, functions known to be influenced by the GH/IGF-1 axis. The interaction with the opioid system was studied by an acute treatment with morphine. The levels of the transcripts for GHR and GHBP in the rat hippocampus and spinal cord were decreased 4 h after the injection of the opiate and restored to normal levels after 24 h. Young and aged rats injected with GH or IGF-1 showed differential gene regulation of subunits of the NMDA subtype of glutamate receptor in the hippocampus. This indicates an age-related difference in the sensitivity to GH/IGF-1 mediated effects on memory functions. Moreover, hypophysectomized rats treated with GH showed improved performance in the Morris water maze, a spatial memory task. The effect was accompanied with an increase in transcripts for NMDA receptor subunits and its associated membrane anchoring PSD-95 protein. Taken together, the results suggest that GH and/or IGF-1 play important roles in mechanisms associated with cognitive functions.
Miró, Vera Aira Yira. "Development of analytical methods based on Near Infrared Spectroscopy for monitoring of pharmaceutical and biotechnological processes and control of new psychoactive substances." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669569.
Повний текст джерелаLa espectroscopía de infrarrojo cercano (NIR, por sus siglas en inglés) es una técnica analítica basada en la interacción entre la radiación electromagnética en el rango 780-2500 nm y la materia. El espectro NIR puede considerarse una huella única para cada sustancia o mezcla de ellas, compuesta por bandas resultantes de los sobretonos y combinaciones de las vibraciones fundamentales en la región del infrarrojo medio. Adicionalmente, en muestras sólidas, el espectro NIR es sensible a la dispersión causada por las características físicas de las muestras, de modo que ofrece simultáneamente información sobre cambios físicos y químicos. El aprovechamiento de la información contenida en espectros NIR implica la aplicación de métodos de análisis multivariable. El objetivo general de esta tesis ha sido el desarrollo de métodos analíticos basados en NIR para el seguimiento de procesos farmacéuticos y biotecnológicos, así como para el control de nuevas sustancias psicoactivas (NPS, por sus siglas en inglés). Para ello, se han explorado las siguientes condiciones: i) rangos extendidos de concentración de ingrediente activo (API, por sus siglas en inglés) en la aplicación de la estrategia del espectro de proceso (PS, por sus siglas en inglés) durante etapas de granulación y compactación de preparados sólidos farmacéuticos; ii) identificación de NPS utilizando instrumentos portátiles y de laboratorio, y iii) seguimiento de producción recombinante de Lipasa B de Candida antarctica en Pichia pastoris usando glicerol como fuente de carbono.
The Near Infrared Spectroscopy (NIRS) is an analytical technique based on the interaction of electromagnetic radiation in the wavelength range 780-2500 nm and matter. The NIR spectrum can be considered as a “fingerprint” of each chemical compound or mixture of them, which contains absorption bands that are the result of overtones and combinations of the fundamental vibrations observed in the Mid-Infrared region. Additionally, NIRS of solids is sensible to the scattering effect caused by physical characteristics of the samples, therefore provides simultaneous sensitivity to chemical and physical changes of solids. Because of NIR spectra show broad and overlapped bands makes it necessary the use of Chemometrics, which implies the application of statistical and mathematical methods to such spectral data, for achieving the maximal extraction and collection of useful information from it. The general objective of this doctoral thesis is developing analytical methods based on NIRS for monitoring pharmaceutical and biotechnological processes and for the control of illicit drugs. The following conditions have been considered i) extended active pharmaceutical ingredient (API) concentration ranges during granulation and tableting using the process spectrum (PS), ii) on-site identification of new psychoactive substances (NPS) during police seizing procedures with hand-held and bench-top instruments and iii) inline monitoring of the production of recombinant Lipase B from Candida antarctica in Pichia pastoris using Glycerol as carbon source. i) Extended API concentration ranges during granulation and tableting using the PS The PS is a methodology for preparing calibration sets by adding the changes due to the manufacturing process to NIR spectra of samples prepared at the laboratory, using an algebraic procedure. The PS has successfully included the process contributions during modelling in the central point of API concentration values of diverse formulations, however the properties of this methodology at extreme points of API concentration ranges have not been studied yet. For evaluating such properties, in this work the PS was applied to samples in the range of ± 30% of a nominal API value. Results have shown that the PS performance can be affected by API concentration changes in the studied range, and classical pre-treatments are not enough to overcome this condition. 4 ii) Comparison of the performance of bench-top and hand-held NIR instruments concerning the identification of NPS The NPS are 'legal highs' with molecular differences regarding the structures of illicit controlled drugs, whose emergence have expanded the current synthetic drugs market in a very important way. The feasibility of using portable NIRS instruments for the fast identification of NPS have been previously demonstrated, however, their performance has not been faced to the performance of bench-top instruments. Results presented in this thesis expose that, even when models developed using data from NIRS miniaturized instruments are limited in performance regarding those developed using data provided by bench-top instruments, classification models of NPS based on data from hand-held instruments can be useful to make real-time and on-site decisions that can be confirmed later using high performance analytical instrumentation. iii) Inline monitoring of the production of recombinant Lipase B from Candida antarctica in Pichia pastoris using glycerol as carbon source. The use of new constitutive promoters and recycled carbon sources in the recombinant production of industrial proteins, such as lipases, in the cell factory Pichia pastoris is advantageous for improving production yields and minimizing the cost of the culture medium. The capabilities of a NIR spectrometer with fiber optic coupling for immersion of a transflectance probe were employed for the inline monitoring of the cultivation mentioned in the headline. Quantitative models have been developed for Biomass, Total protein, Nitrogen and Activity, which have demonstrated better prediction capability during the feed batch stage than during the batch stage. Predictions of glycerol values has been probably affected by the formation of hydrogen bonds in the aqueos medium.
Arnroth, Cornelia. "A study of protein aggregation processes using Dynamic Light Scattering : Validation of the technique and experimental trial with an active pharmaceutical ingredient." Thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422862.
Повний текст джерелаHanna, Bishoy. "DEVELOPMENT AND VALIDATION OF A SEMI-PHYSIOLOGICAL PHARMACOKINETIC (PBPK) MODEL TO PREDICT SYSTEMIC AND PULMONARY EXPOSURES AFTER INTRAVENOUS, ORAL ADMINISTRATION AND PULMONARY INHALATION OF SELECTED DRUGS, BUDESONIDE, TOBRAMYCIN AND CIPROFLOXACIN, IN HUMANS." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5470.
Повний текст джерелаRodgers, Ruth Mary. "Pharmaceutical ethics and professional discipline, 1993 to 1997 : an investigation into the Code of Ethics of the Royal Pharmaceutical Society of Great Britain : its implementation and influence on the disciplinary processes of the pharmacy profession dur." Thesis, Cardiff University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425998.
Повний текст джерелаGhashghaei, Ouldouz. "Development of New Multicomponent Processes based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/457764.
Повний текст джерела• La interacción de iminas e isocianuros en presencia de un ácido de Lewis puede conducir a una variedad de tipos estructurales incluyendo diiminoazetidinas. La selección del alcance de la reacción dio lugar a una pequeña biblioteca de aductos de azetidina. También, se prepararon unos pocos aductos de espiro-azetidina usando isatinas. Se propuso un mecanismo unificado para explicar la diversidad estructural que ofrece el proceso. • La inserción de isonitrilos en el enlace N-H de propargilaminas N-sustituidas en presencia de HCl proporcionó sales de imidazolio 1,3,4,5-tetrasustituidas. Como las propargilaminas proceden de reacciones de A3, se estudió el alcance del procedimiento en términos de aldehídos, aminas, alquinos e isocianuros. La reacción de A3 se combinó con la nueva reacción para obtener las sales de imidazolio en un proceso de una sola etapa. También se exploraron las propiedades de los aductos MCR: Como una prueba de concepto, un aducto se utilizó como un ligando NHC para catalizar un acoplamiento estándar de Suzuki. Algunos de los compuestos obtenidos mostraron una potente actividad antiparasitaria contra T. brucei y T. cruzi a nivel nanomolar. • Se estudió una MCR de tipo Reissert catalizada por TMSCl. El procedimiento presenta la inserción de isocianuro en enlace N-Si como paso clave. Se aplicaron métodos computacionales y experimentales para estudiar esta nueva interacción de isocianuros y enlaces N-Si. La reacción produce sales de aminoimidazolio a partir de la incorporación de dos isocianuros en azinas. El nuevo modo de activación ofrece un alcance mucho más amplio. Se realizó incorporación regioselectiva de dos isocianuros distintos. Algunos aductos demostraron potentes propiedades antiparasitarias contra Trypanosoma Brucei y Cruzi. • La aplicación de múltiples reacciones de GBB sobre poliaminoazinas dio lugar a la formación de nuevos tipos estructurales heterocíclicos N-fusionados con varios puntos de diversidad. El modo regioselectivo sobre diaminopirimidinas proporciona una síntesis controlada de aductos no simétricos. Se estudió el alcance de la reacción y se aplicaron modificaciones posteriores para diversificar aún más el resultado estructural del proceso. Los aductos de melamina se aumentaron de tamaño, explotando reacciones de acoplamiento cruzado para conseguir estructuras tridimensionales nanométricas. Los aductos sintetizados mostraron interesantes propiedades fluorescentes sensibles al pH y al medio ambiente. Se sintetizó un nuevo aducto de tipo BODYPY borilado y se usó para teñir lisosomas en células de mamífero. Además, algunos aductos demostraron una potente actividad antiviral contra Adenovirus humanos. Los compuestos seleccionados mostraron afinidad selectiva a las secuencias de ADN de G- quadruplex, lo que sugiere aplicaciones potenciales en química medicinal y biológica.
Ravipati, Dhatri. "Activity of Analogs of Anticancer Drugs on the Serine Protease Enzymes Subtilisin and Chymotrypsin." TopSCHOLAR®, 2011. http://digitalcommons.wku.edu/theses/1134.
Повний текст джерелаJarray, Ahmed. "Mesoscopic modeling, experimental and thermodynamic approach for the prediction of agglomerates structures in granulation processes." Phd thesis, Toulouse, INPT, 2015. http://oatao.univ-toulouse.fr/15112/1/jarray.pdf.
Повний текст джерелаJunior, Michel Bichara Jemael. "Peletização : estudo de processos de incorporação de princípios ativos em péletes inertes." Universidade de Taubaté, 2011. http://www.bdtd.unitau.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=261.
Повний текст джерелаThe pharmaceutical industry has shown a growing interest in pelletization process, which consists of wet agglomeration of fine powders composed of active ingredients and excipients into small spherical unities, with excellent technological and therapeutic advantages. The objective of this work involves the study of processes of incorporation of suspensions in inert pellets, composed of active ingredients and excipients, using two types of processes: 1. Modified Coating Pan and 2. Fluid Bed in top spray and bottom spray systems. The active ingredients used were amlodipine besylate in concentrations of 2.5% and 5% by mass, and benazepril hydrochloride 15% by mass, included in the formulations of suspensions and applied in equal amounts in both processes, in a total of 9 batches. The process performance indicators used for incorporation of the active ingredient in inert pellets were time of application of the suspension (min) and rate of application of the suspension (g/min). The final pellets were evaluated by means of analyses of the physicochemical properties: water content (%), assay of active ingredient (%), uniformity content (%) and dissolution (%). Among the batches tested, the processes in coating pan and fluid bed by bottom spray system had the shortest application time (120 min) for the suspension with amlodipine besylate active with concentration of 2.5%, while the top spray system had an application time of 300 min, since this system was originally designed for granulation process. The process in coating pan showed the highest real rate of application, equal to 6.24 g/min, followed by the bottom spray system with 4.91 g/min, and the top spray system with 1.62 g/min to the suspension with benazepril hydrochloride with concentration of 15%. For the processes in coating pan and fluid bed by the bottom spray system, all physicochemical properties of the pellets of this study are presented within the standards recommended by the pharmaceutical industry, which has not happened for the top spray system with respect to property "assay of active ingredient (benazepril), whose value present was in 12.90%, below the lower limit of 13.50%, which does not guarantee the efficacy of the drug according to the expected action. The results presented confirm the processes of pelletization in coating pan and fluid bed by the bottom spray system as the ideal technique for incorporation of the active ingredient in inert pellets.
Souza, Fernanda Siqueira. "Degradação de poluentes emergentes por processos oxidativos avançados (O3, O3/UV, O3/Fe2+, O3/UV/Fe2+) visando o tratamento de efluentes hospitalares." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/150518.
Повний текст джерелаPharmaceutical compounds (PhCs) are detected in various environmental matrices. These compounds, whether not eliminated by advanced treatment techniques, contribute to bacterial resistance and negative environmental impacts on water resource. Specifically, hospital wastewaster exhibit high concentrations of these compounds mainly by the excretion by patients. In this context, this paper aims to contribute to scientific research regarding hospital wastewater in Brazil, proposing treatment alternatives by ozone to remove PhCs. To achieve this purpose, it conducted a diagnosis in a hospital to identify the consumption of major pharmaceutical classes. With this result, it developed an experimental design to evaluate the most appropriate parameters of the ozonation process for the removal of caffeine (CAF), amoxicillin (AMX) and ampicillin (AMP) in aqueous solutions. This study evaluated the following processes experimentally: O3, O3/UV, O3/Fe2+ O3/UV/Fe2+. The influence of ozone dose, initial PhCs concentration, pH, power UV light applied and Fe2+ initial concentration used as homogeneous catalyst were investigated. Mineralization efficiency was the response variable. Parameters obtained by the experimental design were applied for Atenolol (ATE) and aqueous solutions containing the mixture of all compounds analyzed (CAF, AMX, AMP and ATE). A kinetic study for the determination of reaction constants was carried out for caffeine and atenolol. To evaluate the hospital wastewater treatment, a characterization (detection of pharmaceutical compounds and physico-chemical and toxicological parameters) was performed before and after the process that showed the best mineralization efficiency. In order to extrapolate the studies and evaluate other emergent pollutants, in addition to pharmaceutical compounds, were conducted experiments with 90 compounds such as illicit drugs, hormones and personal care products, which also may be present in hospital wastewater, evaluating the influence of pH and ozone dosage. Main results showed that antibiotics and cardiovascular were the most consumed pharmaceutical classes in the hospital. For the design of experiments, it was observed that all the evaluated compounds were rapidly degraded (100% in less than 15 minutes) and the best mineralization efficiency reached 70.8%, 60.4% and 63.6% for CAF and AMX AMP, respectively. The system O3/UV/Fe2+ obtained the best mineralization efficiency for ATE (67.9%) and mixture of compounds (69.5%). The kinetic study allowed the determination of the kinetic constants: kO3 = 697.46 M-1 s-1 and kOH = 6.41x109 M-1 s-1 for caffeine; and kO3 = 146.56 M-1 s-1 and kOH = 15.29x109 M-1 s-1 for atenolol. Mineralization efficiency for hospital wastewater experiments reached 54.7% by the system O3/UV, being efficient for complete elimination of various PhCs and removal of toxicity. Regarding the removal of 90 emergent pollutants, it was observed that 53.3% of the compounds were completely degraded using a ratio mMO3/MMC = 0.3 at neutral pH. The results indicated that this work contributes to the advance of research on hospital wastewater, because it presents an effective alternative treatment for complete removal of various pharmaceutical compounds, minimizing the negative impact on the environment.