Готові списки джерел за темами / PfTIM

Добірка наукової літератури з теми "PfTIM"

Автор: Grafiati

Опубліковано: 6 вересня 2023

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Статті в журналах з теми "PfTIM"

Ravindra, Gudihal, and Padmanabhan Balaram. "Plasmodium falciparum triosephosphate isomerase: New insights into an old enzyme." Pure and Applied Chemistry 77, no. 1 (January 1, 2005): 281–89. http://dx.doi.org/10.1351/pac200577010281.

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Анотація:

Triosephosphate isomerase (TIM), a central enzyme in the glycolytic pathway, has been the subject of extensive structural and mechanistic investigations over the past 30 years. The TIM barrel is the prototype of the (β/α)8 barrel fold, which is one of the most extensively used structural motifs in enzymes. Mechanistic studies on TIM from a variety of sources have emphasized the importance of loop 6 dynamics for enzyme activity. Several conserved residues in TIM have been investigated by extensive site-directed mutagenesis of the enzyme from yeast, chicken, and trypanosoma. The cloning and sequencing of the TIM gene from the malarial parasite Plasmodium falciparum in 1993 revealed the unexpected mutation of a hitherto conserved residue serine (S96) to phenylalanine (F96). Subsequent results from the genome sequencing programs of Plasmodium falciparum, Plasmodium vivax, and Plasmodium yoelii confirmed the presence of the S96F mutation in malarial parasites. The crystal structure of PfTIM and several inhibitor complexes, including a high-resolution (1.1 Å) structure of the PfTIM 2-phosphoglycerate complex, revealed that loop 6 had a propensity to remain open, even in several ligand bound structures. Furthermore, both open and closed forms could be characterized for the same complex. Since glycolysis is the primary source of ATP for the malarial parasite during the intraerythrocytic stage, glycolytic enzymes present themselves as potential targets for inhibitors. Two distinct approaches have been explored. The use of dimer interface peptides, which interfere with assembly, has proved promising. Inactivation of the enzyme by modification of a cysteine (C13) residue, which lies close to the active site residue, lysine (K12) is another potential strategy. The differential reactivity, of the four-cysteine residues, at positions 13, 126, 196, and 217 in each subunit has been established using electrospray ionization mass spectrometry. Studies of single tryptophan mutants (W11F and W168F) of PfTIM provide a probe to study folding, stability, and inhibitor interactions.

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Lee, So-Hyoun, Jong-Hoon Moon, Chang-Mo Jeong, Eun-Bin Bae, Chung-Eun Park, Gye-Rok Jeon, Jin-Ju Lee, Young-Chan Jeon, and Jung-Bo Huh. "The Mechanical Properties and Biometrical Effect of 3D Preformed Titanium Membrane for Guided Bone Regeneration on Alveolar Bone Defect." BioMed Research International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/7102123.

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The purpose of this study is to evaluate the effect of three-dimensional preformed titanium membrane (3D-PFTM) to enhance mechanical properties and ability of bone regeneration on the peri-implant bone defect. 3D-PFTMs by new mechanically compressive molding technology and manually shaped- (MS-) PFTMs by hand manipulation were applied in artificial peri-implant bone defect model for static compressive load test and cyclic fatigue load test. In 12 implants installed in the mandibular of three beagle dogs, six 3D-PFTMs, and six collagen membranes (CM) randomly were applied to 2.5 mm peri-implant buccal bone defect with particulate bone graft materials for guided bone regeneration (GBR). The 3D-PFTM group showed about 7.4 times higher mechanical stiffness and 5 times higher fatigue resistance than the MS-PFTM group. The levels of the new bone area (NBA, %), the bone-to-implant contact (BIC, %), distance from the new bone to the old bone (NB-OB, %), and distance from the osseointegration to the old bone (OI-OB, %) were significantly higher in the 3D-PFTM group than the CM group (p<.001). It was verified that the 3D-PFTM increased mechanical properties which were effective in supporting the space maintenance ability and stabilizing the particulate bone grafts, which led to highly efficient bone regeneration.

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Choi, In-Oh, Ji-Su Oh, Sang-Joun Yu, Byung-Ock Kim, and Won-Pyo Lee. "Retrospective Analysis of the Effect of Three-Dimensional Preformed Titanium Mesh on Peri-Implant Non-Contained Horizontal Defects in 100 Consecutive Cases." Applied Sciences 11, no. 2 (January 19, 2021): 872. http://dx.doi.org/10.3390/app11020872.

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This study aimed to clinically and radiographically evaluate the results of guided bone regeneration (GBR) using three-dimensional preformed titanium mesh (3-D-PFTM) for non-contained horizontal defects in 100 consecutive cases. This study involved 100 patients (129 implants) with peri-implant non-contained horizontal defects. The patients were divided into three groups: 3-D-PFTM alone (Group 1), 3-D-PFTM plus cross-linked collagen membrane (Group 2), and 3-D-PFTM plus non-cross-linked collagen membrane (Group 3). Each implant was evaluated radiographically using CBCT at baseline and 6 months postoperatively. At the platform level, the mean horizontal hard tissue gain of all the sites was 3.1 ± 1.3 mm at 6 months postoperatively. The mean rate of mesh exposure was 11.8% in Group 1, 4.2% in Group 2, and 5.0% in Group 3. The mean hard tissue gain rate was 71.0 ± 23.0% in group 1, 84.2 ± 21.5% in group 2, and 84.0 ± 22.9% in group 3. Groups 2 and 3 showed significantly higher hard tissue gain rates than group 1. However, there was no significant difference between the rates in groups 2 and 3. Within the limitations of this study, 3-D-PFTM should be considered as a valuable option for GBR for peri-implant non-contained horizontal defects. The use of an additional resorbable collagen membrane provides additional advantages.

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Bhuyan, Mrinal, Debadatta Saha, and Basanta Kumar Baishya. "An analysis of factors determining the requirement of ventriculoperitoneal shunt surgery in the children suffering from posterior fossa tumour: a single centre retrospective review." International Surgery Journal 7, no. 4 (March 26, 2020): 1025. http://dx.doi.org/10.18203/2349-2902.isj20201013.

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Background: Hydrocephalus is a relatively common occurrence in a children suffering from the posterior fossa tumour (PFTm). However, there is a divided opinion regarding the ventriculoperitoneal shunt (VPS) surgery before the posterior fossa tumour resection in a child. For the better clinical outcome, we should be able to predict which patient will require VPS following the resection of PFTm. Purpose of our retrospective analysis is to analyse various factors that predicts the necessity of VPS following PFTm resection.Methods: A consecutive series of twenty-six patients who underwent PFTm resection without undergoing VPS preoperatively are analysed in our series.Results: In our series, we found that the younger age at presentation, incomplete tumour resection, longer period of artificial ventilatory support, insertion of external ventricular drain (EVD) and its duration during the postoperative period correlate the necessity of VPS following PFTm resection. However, the severity of hydrocephalus prior to tumor surgery, tumour size, anatomical location of the tumour, tumour dissemination, use of Dural grafts during closure and histopathological type do not predict the requirement of the VPS following PFTm.Conclusions: Patients who are younger at diagnosis should be treated with utmost importance. Gross total resection should be the goal. Factors which predict the likelihood of the EVD which parallels the likelihood of postresection hydrocephalus must be prevented for the better clinical outcome.

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Van Voorhis, Wesley C., Kasey L. Rivas, Pravin Bendale, Laxman Nallan, Carolyn Hornéy, Lynn K. Barrett, Kevin D. Bauer, et al. "Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase." Antimicrobial Agents and Chemotherapy 51, no. 10 (July 2, 2007): 3659–71. http://dx.doi.org/10.1128/aac.00246-07.

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ABSTRACT New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFT) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFT and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor oral bioavailability and rapid clearance from the circulation of rodents. In this paper, we validate both the Caco-2 cell permeability model for predicting THQ intestinal absorption and the in vitro liver microsome model for predicting THQ clearance in vivo. Incremental improvements in efficacy, oral absorption, and clearance rate were monitored by in vitro tests; and these tests were followed up with in vivo absorption, distribution, metabolism, and excretion studies. One compound, PB-93, achieved cure when it was given orally to P. berghei-infected rats every 8 h for a total of 72 h. However, PB-93 was rapidly cleared, and dosing every 12 h failed to cure the rats. Thus, the in vivo results corroborate the in vitro pharmacodynamics and demonstrate that 72 h of continuous high-level exposure to PFTIs is necessary to kill plasmodia. The metabolism of PB-93 was demonstrated by a novel technique that relied on double labeling with a radiolabel and heavy isotopes combined with radiometric liquid chromatography and mass spectrometry. The major liver microsome metabolite of PB-93 has the PFT Zn-binding N-methyl-imidazole removed; this metabolite is inactive in blocking PFT function. By solving the X-ray crystal structure of PB-93 bound to rat PFT, a model of PB-93 bound to malarial PFT was constructed. This model suggests areas of the THQ PFTIs that can be modified to retain efficacy and protect the Zn-binding N-methyl-imidazole from dealkylation.

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Lee, So-Ra, Tae-Sik Jang, Chang-Su Seo, In-Oh Choi, and Won-Pyo Lee. "Hard Tissue Volume Stability Effect beyond the Bony Envelope of a Three-Dimensional Preformed Titanium Mesh with Two Different Collagen Barrier Membranes on Peri-Implant Dehiscence Defects in the Anterior Maxilla: A Randomized Clinical Trial." Materials 14, no. 19 (September 27, 2021): 5618. http://dx.doi.org/10.3390/ma14195618.

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Анотація:

This single-blinded, randomized, controlled study aimed to clinically and radiographically evaluate hard tissue volume stability beyond the bony envelope using three-dimensional preformed titanium mesh (3D-PFTM) for peri-implant dehiscence defects in the anterior maxilla. A total of 28 patients who wished to undergo implant surgery combined with guided bone regeneration (GBR) after extraction of a single maxillary anterior tooth were randomly assigned to two groups depending on the type of collagen membrane used, additionally with the 3D-PFTM—test (n = 14, cross-linked collagen membrane; CCM) and control (n = 14, non-cross-linked collagen membrane; NCCM) groups. Each implant was evaluated radiographically using CBCT at baseline, immediately after surgery, and at 6 months postoperatively. The relative position and distances from the bony envelope to the outlines of the augmented ridge were further determined immediately after GBR and 6 months after healing. At the platform level, the mean horizontal hard tissue gain (HG) at all the sites was 2.35 ± 0.68 mm at 6 months postoperatively. The mean HG rate was 84.25% ± 14.19% in the CCM group and 82.56% ± 13.04% in the NCCM group, but the difference was not significant between the groups. In all cases, HG was maintained beyond the bony envelope even after 6 months of GBR. This study suggests that 3D-PFTM should be considered a valuable option for GBR for peri-implant dehiscence defects in the anterior maxilla. In addition, 3D-PFTM may confer predictable hard tissue volume stability even after the healing period of hard tissue augmented outside the bony envelope by GBR.

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Skariya, P. D., M. Satheesh, Edwin Raja J. Dhas, and G. Chandrasekar. "Investigation on Microstructural Examination of Flux Bounded TIG Weldments in Post Weld Heat Treated State." Journal of Computational and Theoretical Nanoscience 16, no. 2 (February 1, 2019): 512–15. http://dx.doi.org/10.1166/jctn.2019.7760.

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Анотація:

The structural material identified for this work is 15CDV6 steel belongs to the category of High strength low alloy (HSLA) family. This research is conducted in the area of Powdered flux TIG (PFTIG) and Flux bounded TIG (FBTIG) welding with the assistance of optimum process parameters procured from Grey wolf optimization tool generated in MATLAB software. The optimum nanopowder and flux gap obtained from PFTIG and FBTIG welding are utilized for the fabrication of closed square butt joint. The microstructural characterization of FBTIG weldments is analyzed in Post weld heat treated (PWHT) condition. The microstructural examinations were conducted with the help of optical and scanning electron microscopy (SEM) to evaluate the structures in the weld zone, Heat affected zone and parent material. The presence of coarse grain structure observed in the WZ leads to the lower strength and hardness of the weldment. The presence of tempered martensite in the HAZ induces strength and toughness to the region.

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Wei, Kexi, Guixiu Wen, Yan Zhao, Zhenghuan Lin, Xiaofei Mei, Limei Huang, and Qidan Ling. "Diarylmaleimide fluorophores: intensely emissive low-band-gap guest for single white polymers with highly efficient electroluminescence." Journal of Materials Chemistry C 4, no. 41 (2016): 9804–12. http://dx.doi.org/10.1039/c6tc03348b.

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Intensely emissive diarylmaleimides PM and TM were introduced into the backbone of polyfluorene (PF) to obtain single white polymers, PFPM and PFTM. PFPM showed highly efficient and white electroluminescence for effective energy transfer from the PF host to the maleimide guest.

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Skariya. P. D et al.,, Skariya P. D. et al ,. "Experimental Investigation of Pftig Welding Process on 15CDV6 Steel using Nanopowders." International Journal of Mechanical and Production Engineering Research and Development 8, no. 4 (2018): 237–46. http://dx.doi.org/10.24247/ijmperdaug201826.

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Oliveira, Rafaela Ribeiro de, André Luis Calado Araújo, and Marco Antonio Calazans Duarte. "Estudo do potencial de formação de trihalometanos na lagoa de Extremoz (RN)." Engenharia Sanitaria e Ambiental 25, no. 2 (March 2020): 315–22. http://dx.doi.org/10.1590/s1413-41522020181889.

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RESUMO O potencial de formação de trihalometanos (PFTHM) é uma metodologia utilizada para avaliar a possibilidade de formação de subprodutos da desinfecção (SPD) por cloração durante o processo de tratamento da água. Trihalometanos (THM) são compostos organoclorados e representam a soma de clorofórmio, diclorobromometano, dibromoclorometano e bromofórmio, sendo a principal classe de SPD formados a partir da reação entre o cloro residual livre e a matéria orgânica natural (MON) presente na água bruta de mananciais de superfície. Esta pesquisa teve como objetivo avaliar o PFTHM resultante da aplicação de cloro na água bruta da lagoa de Extremoz, cuja tecnologia de tratamento utilizada é a filtração direta, seguida de desinfecção com cloro. Os resultados obtidos indicaram presença de matéria orgânica natural hidrofílica com predominância de ácidos fúlvicos na água bruta do manancial. A concentração média de TTHM7 (4,22 mg.L-1) revelou que a água do manancial possui forte potencialidade para formação de compostos orgânicos halogenados. O clorofórmio representou cerca de 80% da concentração total de THM nos ensaios realizados. Foram observadas correlações fortes e significativas entre as variáveis dureza (R = 0,90 e p = 0,005) e cor aparente (R = -0,93 e p = 0,002) da água bruta, resultados que indicaram que íons Ca2+ e Mg2+ podem promover a formação de THM, assim como a cor aparente.

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Більше джерел

Дисертації з теми "PfTIM"

Bandyopadhyay, Debarati. "Probing the Role of Highly Conserved Residues in Triosephosphate Isomerase : Biochemical & Structural Investigations." Thesis, 2015. http://etd.iisc.ernet.in/2005/3602.

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Conserved residues in protein are crucial for maintaining structure and function, either by direct involvement in chemistry or indirectly, by being essential for folding, stability and oligomerisation and are mostly clustered near active sites. The variability of sequences of the same protein from diverse organisms is a reflection of the selective pressures of evolution. Sequence conservation analysis with 3397 bacterial triosephosphate isomerase (TIM) sequences using Plasmodium falciparum (Pf) TIM as template, showed full conservation of ten residues, K12, T75, H95, E97, C126, E165, P166, G209, G210 and G228. The integrity of the enzyme active site, which lies near the dimer interface, makes TIM an obligatory dimer. Attempts to engineer active monomeric TIM have not been successful. The present study assesses the effects of mutations at fully conserved position 75 (Thr) and the highly conserved position 64 (Q: 3011, E: 383) near the dimer interface, using the recombinant Plasmodial enzyme. Residue 64, Gln in Pf, and T75 interact with the catalytic E97 and K12, respectively. Preliminary analysis of available crystal structures showed that Gln 64 takes part in a single intersubunit interaction and maintains the obligatory strained backbone angles of the catalytic K12 residue, while Thr 75 is involved in four intersusunit hydrogen bond interactions. This led to the hypothesis that mostly, Gln at position 64 is crucial for enzyme activity and Thr at position 75 for the integrity of the dimer. Biophysical and kinetic data are reported for four T75 (T75S/V/C/N) and two Q64 (Q64N/E) mutants. The major findings revealed that the mutations at position 64 have a significant effect on dimer integrity with a 1000 fold increase in the dimer dissociation constant compared to the wild type enzyme, while dimer stability was unimpaired for the T75 mutants. Concentration dependence of activity yielded an estimate of dimer dissociation constant (Kd) values (Q64N 73.7±9.2 nM and Q64E 44.6±8.4 nM). Enzyme activity values of the T75 mutants are comparable to the wild type, except for T75N which shows a 4-fold drop in activity. All four T75 mutants show a dramatic fall in activity between 35 °-45 °C. Crystal structure determination of the T75S/V/N mutant offers insights into the variation in local interactions with T75N showing the largest changes. These results were unanticipated emphasising the uncertainties involved in inferring functional and structural role for individual residues based only on analysis of interactions observed in crystal structures. Nanospray ionisation mass spectrometric studies has also been used to probe the oligomeric properties of the three mutant proteins Q64N, Q64E and T75S and the wild type enzyme in the gas phase. The gas phase distributions of dimeric and monomeric species have been examined under a wild range of collision energies (40 – 160 eV). The order in the gas phase, PfTIM wild type > T75S > Q64E ~ Q64N, together with the solution phase experiments described above establish the importance of Q64 and T75 in influencing stability and activity. Inhibition studies with a 27 residue synthetic dimer interface peptide and the Q64 mutants establish that the interaction between the protein and the peptide was facilitated in the case of monomeric species.

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Тези доповідей конференцій з теми "PfTIM"

Qi, Yanan, Yao Fu, Tan Wang, and Hongqiang Lv. "Pftom: a Blockchain based on Fingerprint." In 2020 Chinese Automation Congress (CAC). IEEE, 2020. http://dx.doi.org/10.1109/cac51589.2020.9326945.

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Звіти організацій з теми "PfTIM"

Cheng, Su Lan, Gregory Fiumara, and Craig Watson. PFTII report plain and rolled fingerprint matching with proprietary templates. Gaithersburg, MD: National Institute of Standards and Technology, 2011. http://dx.doi.org/10.6028/nist.ir.7821.

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