Дисертації з теми "Peritumoral"
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Simis, André. "Edema peritumoral em meningiomas benignos: correlação com fatores clínicos, radiológicos, cirúrgicos e com recorrência tumoral." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12022008-132122/.
Повний текст джерелаINTRODUCTION: Approximately 60% of meningiomas are associated with peritumoral edema.Various causative factors have been discussed in the literature. PURPOSES: Investigate the correlation of peritumoral edema with clinical, radiological and surgical aspects, and recurrence rate of meningiomas. METHODS: Sixty one benign meningiomas submitted to surgical treatment by the Group of Brain Tumors and Metastasis of the Division of Neurosurgery of the Hospital das Clínicas of São Paulo Medical School of São Paulo University. All patients underwent complete surgical ressection (Simpson 1 and 2) and were excluded the atypical and malignant hystopathological grades. The tumors located in the cavernous sinus, tuberculum sellae region, foramen magnum region, ventricular space and petroclival region were excluded. RESULTS: Edema extention had a positive correlation with the higher recurrence rates (p = 0,042) and with the presence of irregular margins (p < 0,011) on bivariate analysis. Meningiomas with greater edema sizes also showed correlation with large meningiomas (p = 0,035) and the ones with smaller edema sizes correlated with the tentorial location (p=0,032). Multivariate analysis showed an association between peritumoral brain edema and the presence of seizures (Odds ratio=3,469), large meningiomas (Odds ratio=15,977), and for each cubic centimeter added to its size, the risk of edema increased 1,082 times (Odds ratio). CONCLUSION: Peritumoral brain edema correlated with recurrence, irregular margins, seizures and larger tumors. The tentorial location demonstrated smaller edema sizes. Peritumoral brain edema may be related to meningioma\'s invading potentiality and may play a role in the recurrence pontential of the tumor. As a consequence, it\'s reasonable to consider edema\'s presence as an additional factor to be taken into account when arranging layout of strategies for meningiomas treatment.
Vieira, Fabricio Le Draper. "Tipagem das células do infiltrado inflamatório peritumoral em carcinoma de células escamosas da mucosa bucal: correlação com expressão de Ki67." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4554.
Повний текст джерелаThe utilization of immunohistochemical techniques as biological markers, such as Ki67, that allows the evaluation of the cell proliferation in malignancies, has been advocated as an important way of investigating the biological behavior of cancer, resulting in contributions to the establishment of prognosis and development of new treatment protocols. In this study, using immunohistochemical methods with avidin-biotin-peroxidase, we have assessed the expression of Ki67 in samples of oral squamous cell carcinoma with different patterns of histologic differentiation. The results showed that the cellular immune response is the major deffence mechanisnc in squamous cell carcinoma of the oral mucosa, expressed by the large number of T lymphocytes and macrophages, and expression of Ki67 is related to mitotic index associated with cell proliferation and neoplastic differentiation of tumor.
Silva, Júlio César Thomé de Souza. "Correlação da localização topográfica e do edema peritumoral em pacientes com glioma recidivo com a resposta terapêutica ao álcool perílico." Niterói, 2010. https://app.uff.br/riuff/handle/1/4846.
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Universidade Federal Fluminense. Hospital Universitário Antonio Pedro
Hospital Federal de Ipanema
Hospital Municipal Souza Aguiar
Introdução: Gliomas são tumores cerebrais primários caracterizados pelo crescimento difuso e invasivo. Estudo biomatemático de proliferação e migração dos gliomas propõe que o crescimento de tumores na substância cinzenta profunda cerebral teria um intervalo de tempo maior comparado a lesões situadas na substância branca lobar, onde a invasão e migração seriam mais rápidas. Objetivo: Estabelecer uma correlação da topografia tumoral e edema peritumoral com a resposta terapêutica à administração intranasal do álcool perílico (AP) em pacientes com glioblastoma (GBM) recidivo após tratamento convencional. Métodos: A coorte incluiu o estudo retrospectivo de 119 pacientes com glioma recidivo, sendo 52 em tratamento paliativo de suporte (grupo controle não pareado) e 67 que foram incluídos no Estudo Fase I/II do álcool perílico e receberam administração pela via inalatória de 440 mg de AP diariamente durante o período de Janeiro 2005 a Dezembro 2009. Os parâmetros avaliados incluíram aspectos clínicos e de neuroimagem: topografia tumoral, volume tumoral, presença de desvio da linha média e extensão de edema peritumoral; análise dos dados demográficos, sintomas iniciais e sobrevida global. Análise estatística foi realizada usando testes log rank. A sobrevida global foi determinada pelo método de Kaplan-Meier, incluindo intervalos de confiança de 95%. Resultados: Pacientes do grupo controle apresentaram sobrevida reduzida (p < 0,0001) em relação ao grupo tratado com AP. Dentre os 67 pacientes com GBM, 14 (21%) apresentavam localização talâmica e 53 (79%) localização lobar. Pacientes com tumor localizado na região do tálamo sobreviveram significativamente mais tempo do que aqueles com tumor localizado na região lobar (log rank test, p = 0,0003). Pacientes que apresentaram regressão tumoral acompanhada de redução do edema peritumoral apresentaram resposta clínica positiva, enquanto aqueles com regressão tumoral sem redução do edema peritumoral apresentaram evolução clínica desfavorável, independentemente da topografia tumoral. Presença de desvio da linha média (> 1 cm) foi estatisticamente significante como fator de risco para menor sobrevida (log rank test, p = 0,0062). Conclusões: Este estudo sugere que: (1) pacientes com tumor localizado na região profunda (tálamo) apresentaram sobrevida média maior do que pacientes com tumor localizado na região lobar; (2) edema peritumoral foi um fator determinante na sintomatologia, provavelmente implicado na morbidade podendo estar relacionado com a característica de invasividade do glioma maligno. Esses achados apóiam a teoria de que fatores presentes em diferentes microambientes do tecido cerebral (tálamo, córtex) possam contribuir para o processo de progressão tumoral, para o prognóstico clínico e a resposta terapêutica ao álcool perílico administrado pela vias inalatória
Introduction: Gliomas are primary brain tumors are characterized by diffuse and invasive growth. Study biomathematical proliferation and migration of gliomas suggests that the growth of tumors in deep brain gray matter would have a longer time interval compared with lesions in the lobar white matter, where the invasion and migration would be faster. Objective: To establish a correlation of peritumoral edema and tumor topography with the therapeutic response to intranasal administration of perillyl alcohol (PA) in patients with glioblastoma (GBM) relapsing after conventional treatment. Methods: The cohort included a retrospective study of 119 patients with relapsing glioma, 52 palliative care support (control group) and 67 that were included in the Study Phase I / II and received perillyl alcohol administration by inhalation of 440 mg AP daily during the period January 2005 to December 2009. The parameters evaluated included clinical and neuroimaging: topography tumor, tumor volume, presence of midline shift and extent of peritumoral edema, analysis of demographic data, initial symptoms and overall survival. Statistical analysis was performed using log rank tests. Overall survival was determined by Kaplan-Meier, including 95% confidence intervals. Glioma is a primary brain tumor characterized by diffuse growth and invasiveness. The pattern of differential tumor growth and invasiveness suggest that patients with tumoral lesion located in the lobar white matter region present lower survival rate than patients with lesion located in deep brain gray matter (thalamo). Objective: To establish a correlation between tumor topography and peritumoral edema with the therapeutic response to intranasal administration of perillyl alcohol (POH). Methods: This retrospective study analyzed 119 patients with recurrent glioma being 52 under supportive treatment (control group) and 67 included in the Phase I/II clinical trial that received intranasal administration of 440 mg daily AP from January 2005 to December 2009. The following parameters were analyzed: clinical assessment; demographic data, symptoms and overall survival, neuroimage analysis of topography including tumor volume, midline shift and extent of peritumoral edema. Statistical analysis was performed using log rank tests. The overall survival was determined by the Kaplan-Meier method, including 95% confidence intervals. Results: Patients from control group showed reduced overall survival (p < 0,0001) in comparison with patients included in the Phase I/II that received treatment with perillyl alcohol. Among 67 GBM patients, 14 (21%) had tumoral lesion in the thalamic region and 53 (79%) in the lobar region. Patients with thalamic tumor survived significantly longer than those with tumor located in the lobar region (log rank test, p = 0.0003). Patients with tumor regression with reduction of peritumoral edema had positive clinical response, whereas poor prognosis was observed in those with tumor regression but without reduction of peritumoral edema. Presence of midline shift (> 1 cm) was statistically significant as a risk factor for shorter survival (log rank test, p = 0062). Conclusions: This study indicates that: 1) patients with tumoral lesion in the deep region (thalamic) have longer overall survival than GBM patients with tumors in the lobar region; 2) presence of peritumoral edema contributes strongly to symptoms and is likely to influence morbidity and the invading potential of malignant glioma. These findings support the hypothesis that interaction between glioma cells and different brain microenvironment (thalamo, cortex) can influence the process of glioma progression, clinical prognosis and therapeutic response to intranasal delivery perillyl alcohol
Grochot, Rafael Maciel. "Expressão do PD-L1 em neoplasias cervicais e seu impacto em sobrevida associado à infiltração linfocitária peritumoral e à expressão de FOXP3." reponame:Repositório Institucional da UCS, 2018. https://repositorio.ucs.br/11338/3902.
Повний текст джерелаMendes, Suzanny Oliveira. "Perfil da expressão de HIF-1α em células linfoides do infiltrado inflamatório peritumoral e intratumoral como marcador prognóstico do carcinoma epidermoide de cavidade oral". reponame:Repositório Institucional da UFES, 2014. http://repositorio.ufes.br/handle/10/1887.
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O complexo transcricional HIF-1 é responsável por controlar a transcrição de mais de 100 genes envolvidos em resposta celular a hipóxia. A subunidade HIF-1α é estabilizada em condições de hipóxia e dimeriza-se com um a subunidade HIF-1β, formando o complexo HIF-1 transcricionalmente ativo. Em células inflamatórias, uma elevada expressão de HIF-1α pode induzir os linfócitos à imunossupressão, reduzindo o reconhecimento dos antígenos tumorais, permitindo o crescimento tumoral. O presente trabalho objetivou investigar a relação entre a expressão de HIF-1α em linfócitos do infiltrado inflamatório intratumoral e peritumoral de 56 pacientes com carcinoma epidermoide de cavidade oral. Os resultados indicaram um valor prognóstico para esta expressão. Uma elevada expressão da HIF-1α em células do infiltrado inflamatório peritumoral foi significantemente relacionada com o pior prognóstico do paciente, enquanto esta elevada expressão nos linfócitos na região intratumoral foi correlacionado com um melhor prognóstico. Um perfil de risco indicando a chance para a recidiva e óbito foi desenhado baseado na expressão de HIF-1α nos linfócitos do infiltrado inflamatório peritumoral e intratumoral, definindo os riscos baixo, intermediário e alto. Este perfil de risco foi hábil para determinar que a expressão forte de HIF-1α nos linfócitos peritumorais são relacionados com um pior prognóstico, independente da expressão nas células intratumorais. A expressão fraca de HIF-1α nos linfócitos peritumorais e forte nos linfócitos intratumorais foram considerados um perfil de baixo risco, mostrando nenhum caso de recidiva da doença e óbito decorrente da doença. O risco intermediário foi associado com baixa expressão de HIF-1α tanto em infiltrado inflamatório intratumoral como peritumoral. Estes resultados sugerem que a expressão da HIF-1α em células linfoides do infiltrado inflamatório intratumoral e peritumoral pode exercer um papel importante como um marcador prognóstico tumoral.
The HIF-1 transcriptional complex is responsible for controlling transcription of over 100 genes involved in cell hypoxia response. HIF-1α subunit is stabilized in hypoxia conditions, dimerizes with HIF-1β forming the active HIF-1 transcriptional factor. In inflammatory cells, high HIF-1α expression might induce lymphocytic immunosuppression, decreasing tumoral antigen recognition, allowing tumor growth. The present work aimed to investigate the relationship between HIF-1α expression in lymphocytes inflammatory infiltrate from intratumoral and peritumoral region of 56 patients with oral cancer. Data indicates a prognostic value for this expression. High HIF-1α expression in peritumoral inflammatory cells was significantly related to worse patient outcome, whereas high expression in the intratumoral lymphoid cells correlates with a better prognosis. A risk profile indicating the chance of disease relapse and death was designed based on HIF-1α expression in inflammatory infiltrate cells, defining low, intermediate and high risks. This risk profile was able to determine that high HIF-1α expression in peritumoral lymphocytes correlates with worse prognosis, independently of intratumoral inflammatory infiltrate expression. Low HIF-1α in peritumoral lymphocytes and high expression in the intratumoral lymphocytes was considered a low risk profile, showing no cases of disease relapse and disease related death. Intermediate risk was associated with low HIF-1α expression in inflammatory infiltrate intratumoral and peritumoral. in tumor and tumor margins. These results suggest that HIF-1α expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker.
MENDES, S. O. "Perfil da Expressão de Hif-1 Alfa em Células Linfoides do Infiltrado Inflamatório Peritumoral e Intratumoral Como Marcador Prognóstico do Carcinoma Epidermoide de Cavidade Oral." Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/4481.
Повний текст джерелаO complexo transcricional HIF-1 é responsável por controlar a transcrição de mais de 100 genes envolvidos em resposta celular a hipóxia. A subunidade HIF-1α é estabilizada em condições de hipóxia e dimeriza-se com um a subunidade HIF-1β, formando o complexo HIF-1 transcricionalmente ativo. Em células inflamatórias, uma elevada expressão de HIF-1α pode induzir os linfócitos à imunossupressão, reduzindo o reconhecimento dos antígenos tumorais, permitindo o crescimento tumoral. O presente trabalho objetivou investigar a relação entre a expressão de HIF-1α em linfócitos do infiltrado inflamatório intratumoral e peritumoral de 56 pacientes com carcinoma epidermoide de cavidade oral. Os resultados indicaram um valor prognóstico para esta expressão. Uma elevada expressão da HIF-1α em células do infiltrado inflamatório peritumoral foi significantemente relacionada com o pior prognóstico do paciente, enquanto esta elevada expressão nos linfócitos na região intratumoral foi correlacionado com um melhor prognóstico. Um perfil de risco indicando a chance para a recidiva e óbito foi desenhado baseado na expressão de HIF-1α nos linfócitos do infiltrado inflamatório peritumoral e intratumoral, definindo os riscos baixo, intermediário e alto. Este perfil de risco foi hábil para determinar que a expressão forte de HIF-1α nos linfócitos peritumorais são relacionados com um pior prognóstico, independente da expressão nas células intratumorais. A expressão fraca de HIF-1α nos linfócitos peritumorais e forte nos linfócitos intratumorais foram considerados um perfil de baixo risco, mostrando nenhum caso de recidiva da doença e óbito decorrente da doença. O risco intermediário foi associado com baixa expressão de HIF-1α tanto em infiltrado inflamatório intratumoral como peritumoral. Estes resultados sugerem que a expressão da HIF-1α em células linfoides do infiltrado inflamatório intratumoral e peritumoral pode exercer um papel importante como um marcador prognóstico tumoral.
Makdissi, Fabiana Baroni Alves. ""Análise da expressão de E-caderina, Snail e Hakai em células epiteliais de tumor e tecido peritumoral de mulheres com carcinoma ductal invasivo da mama: correlação com comprometimento linfonodal"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-07082006-110753/.
Повний текст джерелаE-cadherin (Ecad) expression may be transcriptionally or post-transcriptionally regulated by Snail and Hakai. Our aim was to determine the expression of Ecad, Snail and Hakai, in epithelial cells (EC) obtained from tumor and its adjacent tissue from women with invasive ductal breast carcinoma (IDC) and evaluate their correlation to the axillary's lymph node (LN+) involvement. Tissue from 45 patients (52% LN+) had their EC recovered by immunomagnetic antibody process, RNA was extracted and real-time RT-PCR was performed using specific primers. Ecad, Snail and Hakai mRNA expression did not vary between tumoral and peritumoral samples and their expression was not correlated to LN involvement
GIANNICE, RAFFAELLA. "Il microambiente peritumorale nel carcinoma dell'endometrio." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/31294.
Повний текст джерелаLemée, Jean-Michel. "Au delà des frontières du glioblastome : caractérisation de la zone péritumorale des glioblastomes." Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0001/document.
Повний текст джерелаGlioblastoma (GB) is a heterogeneous andaggressive tumor, before which therapeutic options arelimited. The study of the macroscopically normalperitumoral brain zone (PBZ) of GB is essential tounderstand its mechanisms of progression andrecurrence.The first objective of this thesis work was tocompare the transcriptomic and proteomic data from theGB tumor area obtained through the “Grand Ouest”glioma Project. The concordance rate between the 2modalities is low. However, one of the common featureis the dysregulation of neurofilament light polypeptide,which could serve as a biomarker potential of GB.The second objective of this thesis was thecharacterization of the PBZ. We have shown that thisarea, similar at first glance to that of healthy braintissue, is not a simple transition area between the GBand healthy brain tissue but a specific entity withcharacteristics of its own. For example, the ZMNpresents a particular phenotype of infiltrating GB cellsand stromal cells and a surexpression of CRYAB andH3F3A proteins.This thesis work was also an opportunity todevelop new intraoperative imaging techniques of thePBZ, with the aim to assess the presence of a tumoralinfiltration and optimize the quality of the surgicalresection.The characterization of this PBZ allows us tobetter understand its involvement in tumorigenesis andthe presence of specific characteristics of this areaopens the door for the detection of specific biomarkersand the development of targeted therapies.This thesis work was led to 2 publications, 2articles submitted and a patent being evaluated andredacted by a patent office
Sarraf, Michel. "Evaluation non-invasive des Gliomes par Imagerie Résonance Magnétique : Effets des traitements anti-angiogéniques (Avastin) sur la microvascularisation et la microarchitecture tumorale et péritumorale." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAS040.
Повний текст джерелаIn neuro-oncology, the effects of anti-angiogenic treatments are not predictable, as observed in glioblastomas treated with Avastin. Only a minority of patients show a significant response to treatment. Conventional imaging modalities are not able to evaluate the efficiency in the early phase of the treatment. Thus, the challenge remains to find and to validate new biomarkers that are able to predict the early response to such therapies.The aim of this work is to develop and implement a preclinical multiparametric magnetic resonance imaging (MRI) protocol for the characterization and follow up of early microvascular and microstructural changes in the tumor and its peritumoral regions after treatment with Avastin. For this purpose, the quantification of the blood volume and Kmodel (an apparent coefficient that is related to the contrast agent (CA) uptake rate), and evaluation of brain microarchitecture by diffusion tensor imaging were developed and evaluated as biomarkers.The Rapid Steady State T1 (RSST1) method was initially developed for blood volume quantification in the absence of CA extravasation. In the first part of this thesis, we have implemented and adapted this MRI technique for the quantification of both blood volume and Kmodel in tumors where the CA extravasates. We developed a mathematical model for the RSST1 signals that accounts for the unidirectional bi-compartmental exchange of CA from the vascular towards the extravascular compartment. This development allows to the quantification of vascular parameters in a rat glioma model (C6). The results were confirmed using another MRI modality, the steady state magnetic susceptibility method, and quantitative histology.In the second part, we studied the sensitivity of the RSST1 method for the follow up of the glioma response to anti-angiogenic treatment under clinical conditions. In this study, the effect of Avastin treatment in a murine orthotopic U87 MG glioma model was analyzed. The RSST1 method demonstrated a high reproducibility in the blood volume quantification and a superior sensitivity in comparison to CA enhanced T1-weighted imaging (T1W-Gd-DOTA) for the detection and follow-up of the tumor response to Avastin, especially in early stages of tumor progression. Blood volume quantification by MRI was correlated to measures obtained by two-photon microscopy.In the last part of this thesis, we have studied the capacity of diffusion tensor imaging (DTI) coupled with FLAIR (fluid-attenuated inversion recovery) MRI and T1w-Gd-DOTA, to characterize tumor, peritumoral, and contralateral regions of the U87MG glioma model. We quantified DTI parameters before and during the invasion of tumor cells induced by Avastin in the peritumoral zone for different administration modes: intravenous and intratumoral via Convention-Enhanced Delivery. Therefore, the delineation of peritumoral regions for each tumor in an early stage was based on anatomical images, that took into account the individual tumor progression at later stages. Significant differences were detected for DTI parameters between the tumor, peritumoral, and contralateral regions and a different evolution of these parameters was noticed according to the Avastin injection mode
Yan, Jiun-Lin. "Characterising peritumoural progression of glioblastoma using multimodal MRI." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267740.
Повний текст джерелаTERRACCIANO, ROSSANA. "Enhancing the Biodistribution and Physicochemical Properties of Gold Nanoparticles by Modifying their Surface Characteristics." Doctoral thesis, Politecnico di Torino, 2023. https://hdl.handle.net/11583/2976597.
Повний текст джерелаLIUZZA, Claudia. "Studio dell'infiltrato linfocitario peritumorale e dei linfociti circolanti in pazienti affetti da melanoma cutaneo." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91265.
Повний текст джерелаγδ T cells are a group of effectors "natural killer" of the innate immune system, which represented an interesting object of study in recent years. The Department of Surgical, Oncology and Dentistry of the University Hospital of Palermo, active for years in respect of scientific research, has recently conducted a study aimed at understanding the potential effect of this immunotherapeutic lymphocyte population to the advanced-stage melanomas. Based on the classification of the American Joint Committee on Cancer ( AJCC ) patients with stage IV malignant melanoma with metastatic cancer have a poor prognosis, with a low 5-year survival. Statistical data estimate that overall survival is less than 10 %, highlighting how few treatments are currently available and reasonably effective. The different therapeutic schemes proposed and approved for the treatment of metastatic melanoma (high-dose interleukin- 2 and chemotherapy) showed an overall response rate of 16 % and 7.5 %, with a low complete response and long-term survival. The study and analysis of the infiltrated peritumoral lymphocytes ( TIL) in patients with malignant melanoma and the pursuit of lymphocytes circulating in the blood stream will allow you to define the key role of γδ T cells, and the potential of the therapeutic treatment of metastatic malignant melanoma.
MOLINELLI, ELISA. "Melanoma e tessuto adiposo peritumorale: studio preliminare sul ruolo delle adipocitochine nella caratterizzazione e prognosi di malattia." Doctoral thesis, Università Politecnica delle Marche, 2021. http://hdl.handle.net/11566/291060.
Повний текст джерелаIn the last decades, the concept of adipose organ has emerged, giving adipose tissue an active endocrine function carried out through the secretion of multiple cytokines and chemokines having a key role not only in maintaining energy homeostasis but also in the pathogenesis of metabolic and inflammatory diseases and in the growth and progression of numerous neoplasms including melanoma. In this preliminary experimental study, we analyzed the expression in the peritumor subcutaneous adipose tissue by qPCR of the most significant adipocytokines involved in the processes of carcinogenesis and metastasis such as Tumor Nescrosis Factor alpha (TNF-alpha), Interleukin- 6 (IL-6), Plasminogen Activator Inhibitor 1 (PAI1), Leptin (LEP), Insulin-like Growth factor 1 (IGF1), Vascular Endothelial Growth Factor A (VEGF-A), Nicotinamide phosphoribosyltransferase (NAMPT), CXC Motif Chemokine Ligand 1 (CXCL1) and CXC Motif Chemokine Ligand 8 (CXCL8) in a population of melanoma patients by comparing the data obtained with the expression of the same cytokines in the subcutaneous adipose tissue of 2 control groups composed respectively of melanocytic nevi and epidemoid cysts. We correlated the results obtained with the main disease prognostic factors to understand their expression in relation to the severity of the disease. We observed a statistically significant increase in the expression of PAI1, NAMPT, LEP and CXCL1 at the level of the peritumor tissue of the melanoma samples compared to the control groups and a correlation of the same with the pathological stage of the disease and in particular with the Breslow thickness (the most important prognostic factor in the pathological staging of melanoma). The main limitation of the study is represented by the small cohort of patients. Studies on larger case series will be necessary to confirm the partial results obtained. Overall, the preliminary results of this study show that the overexpression of adipokines and chemokines in particular PAI1, NAMPT, LEP and CXCL1 not only at the level of the melanomatous lesion but also in the peritumoral adipose tissue, may represent a key event in growth and especially in the local aggressiveness of the neoplasm and therefore opens the hypothesis of a direct oncogenic role of these molecules and of the subcutaneous adipose tissue in the tumorigenesis of melanoma.
Knoop, Richard F. [Verfasser], and Volker [Akademischer Betreuer] Fendrich. "Peritumorale Entzündung, chronische Pankreatitis und Chemoresistenz von Gemcitabin bei der Therapie des Pankreaskarzinoms – Evaluation am transgenen Tumormausmodell / Richard F. Knoop. Betreuer: Volker Fendrich." Marburg : Philipps-Universität Marburg, 2014. http://d-nb.info/1058679880/34.
Повний текст джерелаSteinwandter, Florian [Verfasser], Gerhard [Gutachter] Mall, and Claus Michael [Gutachter] Rödel. "Peritumorales Budding bei kolorektalen Karzinomen : Analyse morphologischer Veränderungen an der Invasionsfront / Florian Steinwandter ; Gutachter: Gerhard Mall, Claus Michael Rödel." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2019. http://d-nb.info/1203206763/34.
Повний текст джерелаFriedrich, Martina [Verfasser], Veit [Akademischer Betreuer] Rohde, Michael [Gutachter] Knauth, Martin [Gutachter] Sommer, and Rainer [Gutachter] Mausberg. "Peritumorale Hirnödeme bei intrakraniellen Meningeomen: Einfluss von Alter, Geschlecht, Tumorgröße, Tumorlokalisation und histologischem Subtyp / Martina Friedrich ; Gutachter: Michael Knauth, Martin Sommer, Rainer Mausberg ; Betreuer: Veit Rohde." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://d-nb.info/1149954434/34.
Повний текст джерелаKremer-Maas, Marion [Verfasser], Verena [Akademischer Betreuer] Kirn, and Jürgen [Akademischer Betreuer] Wolf. "Der Einfluss der peritumoralen Lymphgefäßdichte auf das Tumorstadium und Outcome von Patientinnen mit Endometriumkarzinom / Marion Kremer-Maas ; Akademische Betreuer: Verena Kirn, Jürgen Wolf." Köln : Deutsche Zentralbibliothek für Medizin, 2018. http://d-nb.info/1174678496/34.
Повний текст джерелаBaier, Patricia Maria Gloria. "Prognostische Bedeutung der CEA- und CK-20-Detektion mittels RT-PCR in peritumoralen Lymphknoten von Patienten mit nodal negativem kolorektalen Karzinom im UICC-Stadium I und II." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972767304.
Повний текст джерелаLo, Shih-Ya, and 羅仕雅. "Diffusion Tensor Imaging of Peritumoral Structures." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/75058581597483224347.
Повний текст джерела國立陽明大學
生物醫學影像暨放射科學系暨研究所
96
Peritumoral signal abnormality (PSA) of brain tumors contains varieties of tissues which contain vasogenic edema and/or tumor infiltration. In clinical experience, T2 weighted MR images are always used to identify PSA in tumor patients. However, the two types of signal abnormalities can hardly be distinguished effectively up to date. In this study, diffusion tensor imaging (DTI) was applied to differentiate the complex contents of PSA. Instead of distinguishing the two components directly, reversibility of PSA was proposed as a criterion to differentiate the tissue contents, which may facilitate tumoral delineation and therefore improve the therapeutic efficiency. The study aims to observe the reversibility of PSA via pre- surgical and at least one-month post-surgical follow-up MR images. PSA were classified as reversible if they were normalized in the follow-up MR imaging and as irreversible if remained. The lesion-to-brain fractional anisotropy (FA) ratio of ROIs was determined. The results showed that mean FA ratios for reversible group (0.517 ± 0.086) and irreversible group(0.306 ± 0.056)were with significant difference(p < 0.0001). The reversibility of PSA is predictable by mean FA ratios on DTI. The new model for characterization of peritumoral tissues allows us to refine the delineation of therapeutic targets. It may serve as a biomarker for target delineation and therefore improve therapeutic effects.
Lin, Li-en, and 林立恩. "Diffusion Tensor Images of Metastatic Brain Tumors:the Impact of Peritumoral Edema on White Matter Indices." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/88209165178862397903.
Повний текст джерела國立雲林科技大學
工業工程與管理研究所碩士班
100
In recent year, Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) has become an essential portrait medical treatment, MRI can make extraordinary portrait performances in brain tumor and adjacency edema on medical treatment, DTI can not only observe diversification between brain tumor and white matter fiber bundles but evaluate relationship between tumor and brain tissue. Sometimes brain tumor may undeveloped in T1-weighted MRI, this study will evaluate diversification between brain tumor and other brain tissue by applying region of interest and combining measure index of magnetic resonance diffusion. This thesis will reconstruct 3D visualization for brain tumor and area surrounding edema; then we conduct image fusion after reconstruction. This study will calculate the distance between area surrounding edema and white matter by applying morphological image processing, and then we sort out region of interest, using fractional anisotropy and mean diffusivity to be measurement indicators. This study of brain magnetic resonance imaging include four metastatic cancer patients and two normal subjects, research area cover edema side around tumor of cancer patients and white matter of normal subjects, we develop region of interest by applying morphological image processing. Each step represents that we start three-dimensional dilation to expanse four pixels, in our experiment results; we can find FA rising and MD declining in region of interest of D4、D8 in cancer patients, FA and MD emerge smooth in white matter area beside edema area. FA is the lowest and MD is the highest in D4 in five steps in brain tumor patients experiment results. It demonstrates that the area around tumor will decline direction and rise average diffusion coefficient. This thesis focus on region of interest developed and compares FA and MD with brain tissue in difference area between cancer patients and normal subjects. In our experiments, we can see that results show significant difference in FA and MD in four areas under 90% confidence levels. The values of FA and MD in side of the brain edema and white matter regions outside the area and edema are significant difference(p-value<0.1). The values of FA and MD in side of the brain edema region corresponds to the region and against the side are significant difference(p-value<0.1). The values of FA and MD in brain edema side against the side of the white matter and the corresponding region are significant difference(p-value<0.1). The values of FA and MD in side with the opposition side of the brain tumor area of common concern are significant difference(p-value<0.1).We can find the diversification between tumor and white matter area around tumor; we hope this study can offer some references for medical image.
Chang, Tzu-Yuan, та 張子媛. "Functional characterization of novel α-ketoamide derivatives as potent inhibitors against cathepsin S induced by acidic peritumoral pH of pancreatic cancer". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/4jj3fg.
Повний текст джерелаTing, Yi-Cen, and 丁怡岑. "Microstructural Characterization in the Peritumoral Area of Glioma Patients and in the Corpus Callosum of Normal Subjects Using Neurite Orientation Dispersion and Density Imaging (NODDI)." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/hj8ra4.
Повний текст джерела國立陽明大學
腦科學研究所
107
Diffusion magnetic resonance imaging (dMRI) is a technique for the non-invasive characterization of the microstructure in biological tissues since it is sensitive for the diffusion processes of hydrogen molecules. dMRI is a promising candidate for in vivo quantification of neurite morphology in white matter. Over the past two decades, conventional dMRI method usually focused on Diffusion Tensor Imaging (DTI). DTI was widely used to assess the organization of tissue in white matter, providing some indices to describe changes in biology. The model of DTI describes the diffusive water molecules relevant to free diffusion or hindered anisotropic diffusion homogeneous within each voxel based on the assumption of Gaussian distribution. However, DTI was obtained at single b-value and lacked of specificity for describing tissues in this assumption. Additionally, several advanced dMRI techniques, especially multi-compartment models, have been proposed with complicated assumption for estimating neuron morphology. Neurite Orientation Dispersion and Density Imaging (NODDI) is a clinically feasible technique for estimating the microstructural complexity in central neuron system imaging, post by Zhang et al. in 2012. NODDI is a multi-compartment tissue model based on dMRI, combining a three-compartment tissue model: restricted compartment for non-Gaussian anisotropic diffusion (referring to the space bounded by the membrane of neurites), hindered compartment for Gaussian anisotropic diffusion (referring to the space around the neurites) and isotropic compartment for Gaussian diffusion (referring to the CSF space) in each voxel. Using three compartments, NODDI map not only axons in the white matter but also dendrites in gray matter in each voxel. Compared to DTI indices, NODDI may provide greater specificity to morphology and pathology, e.g. neurite density and orientation dispersion. The aims of this work are to explore the promising indices of diffusion models in characterizing the microstructural complexity in the peritumoral area of gliomas and to show the clinical feasibility and potential capability of NODDI studies. The first chapter gave an overview of dMRI and explained the models of NODDI as well as DTI (Chapter 1). In the chapters 2~5, we investigated the different preprocessing interference on NODDI and DTI as verified by topography of corpus callosum for optimization (Chapter 2), and then we differentiated different types of gliomas and characterized the infiltration in peritumoral area by NODDI and DTI using the optimized preprocessing method (Chapter 3); furthermore, we in-vivo evaluated the simplified NODDI imaging protocol and constructed the semi-automatic regions of interest (ROI) delineation for peritumoral areas (Chapter 4 and 5). Finally, the last chapter gave a conclusion of this thesis (Chapter 6).
CHAKIR, Asmaa. "Characterization of cancer - associated adipose tissue." Doctoral thesis, 2017. http://hdl.handle.net/11562/960114.
Повний текст джерела""Análise da expressão de E-caderina, Snail e Hakai em células epiteliais de tumor e tecido peritumoral de mulheres com carcinoma ductal invasivo da mama: correlação com comprometimento linfonodal"." Tese, Biblioteca Digital de Teses e Dissertações da USP, 2006. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-07082006-110753/.
Повний текст джерелаSalvador, Rute Maria Silva. "Utilização de imunohistoquímica para avaliação da densidade linfática no mesentério de adenocarcinomas do cólon." Master's thesis, 2019. http://hdl.handle.net/10400.1/13582.
Повний текст джерелаIntroduction: Colorectal cancer presents itself as one of the most common neoplasms in developed countries. Their ability to metastization occurs by resource to blood vessels and/or lymphatic vessels. In recent decades the importance of lymphangiogenesis in cancer has been discussed being that as long as the surgical technique for total mesorectal excision (TME) demonstrated positive effects on local recurrences of rectal cancer and, later, with the proposal for the implementation of complete mesocolic excision (CME) surgical technique for colon cancer, the importance of maintaining the integrity of the mesocolon and consequent lymphatic network it is been keeping himself in intense debate. Until the moment has not yet been understood the true benefit of maintaining the integrity of the lymphatic network and, as such, the routine implementation of the CME has not yet occurred. Objective: Determine, in patients with colon adenocarcinoma, the mesenteric lymphatic density in peritumoral regions and in distal regions to the tumor and correlate the lymphatic density mesenteric with different clinic-pathological and clinic-histological features. Methods: Participated in this study 49 patients with adenocarcinoma of the colon with stages T2 and T3. The evaluation of mesenteric lymphatic density was carried out by immunohistochemistry using the antibody monoclonal D2-40 of podoplanin. It was also evaluated the influence that several clinic-pathological and clinic-histological features could have in mesenteric lymphatic density using the IBM SPSS statistical program. Results: There were higher lymphatic densities in the peritumoral region compared to the distal regions of the tumor. The lymphatic peritumoral density was not positively related to any of the clinic-pathological and clinic-histological characteristics analyzed, however, the lymphatic density distal to the tumor demonstrated statistical significance in the relationship with the body mass index, the number of isolated positive lymph node, the depth of invasion of the tumor and the lymph node involvement. Conclusion: The biological role of the lymph vessels in the tumor progression remains controversial. Only the lymphatic density was correlated with the clinic-pathological and clinic-histological parameters in distal regions to the tumor which reflects the importance of a well-executed surgical technique. Further studies are still needed to understand the role of the lymphangiogenesis in the tumor dissemination.
Berendes, Katja. "Wertigkeit intra- und peritumoraler Zysten bei Meningeomen im Erwachsenenalter /." 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014588152&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Повний текст джерелаFriedrich, Martina. "Peritumorale Hirnödeme bei intrakraniellen Meningeomen: Einfluss von Alter, Geschlecht, Tumorgröße, Tumorlokalisation und histologischem Subtyp." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3F8F-7.
Повний текст джерелаRathert, Julian [Verfasser]. "Lesion based fibertracking : ein noninvasiver Traktographie-Algorithmus zur verbesserten Darstellung peritumoraler Faserbahnen in der funktionellen Neuronavigation / vorgelegt von Julian Rathert." 2010. http://d-nb.info/1007160462/34.
Повний текст джерелаBaier, Patricia Maria Gloria [Verfasser]. "Prognostische Bedeutung der CEA- und CK-20-Detektion mittels RT-PCR in peritumoralen Lymphknoten von Patienten mit nodal negativem kolorektalen Karzinom im UICC-Stadium I und II / Patricia Maria Gloria Baier." 2004. http://d-nb.info/972767304/34.
Повний текст джерела