Добірка наукової літератури з теми "Peritumoral"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Peritumoral".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Peritumoral"
Péley, Gábor, István Sinkovics, József Tóth, Emil Farkas, Sándor Keresztes, and István Köves. "Subareolar Injection of Radioactive Colloid for Sentinel Lymph Node Identification in Breast Cancer Patients." American Surgeon 70, no. 7 (July 2004): 625–29. http://dx.doi.org/10.1177/000313480407000713.
Повний текст джерелаMao, Jiaji, Minghui Cao, Fang Zhang, Jingzhong Zhang, Xiaohui Duan, Liejing Lu, Zehong Yang та ін. "Peritumoral administration of IFNβ upregulated mesenchymal stem cells inhibits tumor growth in an orthotopic, immunocompetent rat glioma model". Journal for ImmunoTherapy of Cancer 8, № 1 (березень 2020): e000164. http://dx.doi.org/10.1136/jitc-2019-000164.
Повний текст джерелаKanomata, Naoki. "Peritumoral Muciphage." American Journal of Surgical Pathology 23, no. 7 (July 1999): 863. http://dx.doi.org/10.1097/00000478-199907000-00021.
Повний текст джерелаLev, Robert, and Giovanni DePetris. "Peritumoral Muciphage." American Journal of Surgical Pathology 23, no. 7 (July 1999): 863. http://dx.doi.org/10.1097/00000478-199907000-00022.
Повний текст джерелаVladimirova, Lyubov, Yevgeniya Nepomnyashchaya, Natalya Podzorova, Inna Novikova, Yelena Ulyanova, and Nataliya Abramova. "RECOMBINANT TUMOR NECROSIS FACTOR-THYMOSIN-A1: THE IMPACT ON THE EFFECTIVENESS OF NEOADJUVANT CHEMOTHERAPY AND ANGIOGENESIS IN BREAST CANCER." Problems in oncology 63, no. 1 (January 1, 2017): 76–81. http://dx.doi.org/10.37469/0507-3758-2017-63-1-76-81.
Повний текст джерелаIKEDA, Yukio, and Kiyoshi MATSUMOTO. "Peritumoral Brain Edema." Showa University Journal of Medical Sciences 11, no. 3 (1999): 149–54. http://dx.doi.org/10.15369/sujms1989.11.149.
Повний текст джерелаStöcklein, R., R. Dorn, H. Vogt, A. Wischnik, J. Sciuk, and G. Holl. "Influence of the injection technique on the false negative rate of SLNE in multifocal breast cancer." Nuklearmedizin 47, no. 05 (2008): 216–19. http://dx.doi.org/10.3413/nukmed-0174.
Повний текст джерелаChen, Jiao, Xianfang Ming, Zhen Wang, and Yu Ye. "Analysis of the Performance of Gadoxetic Acid Disodium MRI in Predicting Microvascular Invasion of Hepatocellular Carcinoma." Contrast Media & Molecular Imaging 2022 (September 28, 2022): 1–5. http://dx.doi.org/10.1155/2022/6128845.
Повний текст джерелаGao, Xiang, Haiyan Wang, Shanbao Cai, M. Reza Saadatzadeh, Helmut Hanenberg, Karen E. Pollok, Aaron A. Cohen-Gadol, and Jinhui Chen. "Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue: implications for glioma epileptogenesis." Neurosurgical Focus 37, no. 6 (December 2014): E17. http://dx.doi.org/10.3171/2014.9.focus14485.
Повний текст джерелаDai, Xiao-Meng, Tao Huang, Sheng-Li Yang, Xiu-Mei Zheng, George G. Chen, and Tao Zhang. "Peritumoral EpCAM Is an Independent Prognostic Marker after Curative Resection of HBV-Related Hepatocellular Carcinoma." Disease Markers 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/8495326.
Повний текст джерелаДисертації з теми "Peritumoral"
Simis, André. "Edema peritumoral em meningiomas benignos: correlação com fatores clínicos, radiológicos, cirúrgicos e com recorrência tumoral." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12022008-132122/.
Повний текст джерелаINTRODUCTION: Approximately 60% of meningiomas are associated with peritumoral edema.Various causative factors have been discussed in the literature. PURPOSES: Investigate the correlation of peritumoral edema with clinical, radiological and surgical aspects, and recurrence rate of meningiomas. METHODS: Sixty one benign meningiomas submitted to surgical treatment by the Group of Brain Tumors and Metastasis of the Division of Neurosurgery of the Hospital das Clínicas of São Paulo Medical School of São Paulo University. All patients underwent complete surgical ressection (Simpson 1 and 2) and were excluded the atypical and malignant hystopathological grades. The tumors located in the cavernous sinus, tuberculum sellae region, foramen magnum region, ventricular space and petroclival region were excluded. RESULTS: Edema extention had a positive correlation with the higher recurrence rates (p = 0,042) and with the presence of irregular margins (p < 0,011) on bivariate analysis. Meningiomas with greater edema sizes also showed correlation with large meningiomas (p = 0,035) and the ones with smaller edema sizes correlated with the tentorial location (p=0,032). Multivariate analysis showed an association between peritumoral brain edema and the presence of seizures (Odds ratio=3,469), large meningiomas (Odds ratio=15,977), and for each cubic centimeter added to its size, the risk of edema increased 1,082 times (Odds ratio). CONCLUSION: Peritumoral brain edema correlated with recurrence, irregular margins, seizures and larger tumors. The tentorial location demonstrated smaller edema sizes. Peritumoral brain edema may be related to meningioma\'s invading potentiality and may play a role in the recurrence pontential of the tumor. As a consequence, it\'s reasonable to consider edema\'s presence as an additional factor to be taken into account when arranging layout of strategies for meningiomas treatment.
Vieira, Fabricio Le Draper. "Tipagem das células do infiltrado inflamatório peritumoral em carcinoma de células escamosas da mucosa bucal: correlação com expressão de Ki67." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4554.
Повний текст джерелаThe utilization of immunohistochemical techniques as biological markers, such as Ki67, that allows the evaluation of the cell proliferation in malignancies, has been advocated as an important way of investigating the biological behavior of cancer, resulting in contributions to the establishment of prognosis and development of new treatment protocols. In this study, using immunohistochemical methods with avidin-biotin-peroxidase, we have assessed the expression of Ki67 in samples of oral squamous cell carcinoma with different patterns of histologic differentiation. The results showed that the cellular immune response is the major deffence mechanisnc in squamous cell carcinoma of the oral mucosa, expressed by the large number of T lymphocytes and macrophages, and expression of Ki67 is related to mitotic index associated with cell proliferation and neoplastic differentiation of tumor.
Silva, Júlio César Thomé de Souza. "Correlação da localização topográfica e do edema peritumoral em pacientes com glioma recidivo com a resposta terapêutica ao álcool perílico." Niterói, 2010. https://app.uff.br/riuff/handle/1/4846.
Повний текст джерелаApproved for entry into archive by Ana Lúcia Torres (bfmhuap@gmail.com) on 2017-10-10T15:59:52Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) DISSERTAÇAO JULIO THOME.pdf: 1047008 bytes, checksum: 4e9746314e2b28ff944bb677bb12cbc7 (MD5)
Made available in DSpace on 2017-10-10T15:59:52Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) DISSERTAÇAO JULIO THOME.pdf: 1047008 bytes, checksum: 4e9746314e2b28ff944bb677bb12cbc7 (MD5) Previous issue date: 2010
Universidade Federal Fluminense. Hospital Universitário Antonio Pedro
Hospital Federal de Ipanema
Hospital Municipal Souza Aguiar
Introdução: Gliomas são tumores cerebrais primários caracterizados pelo crescimento difuso e invasivo. Estudo biomatemático de proliferação e migração dos gliomas propõe que o crescimento de tumores na substância cinzenta profunda cerebral teria um intervalo de tempo maior comparado a lesões situadas na substância branca lobar, onde a invasão e migração seriam mais rápidas. Objetivo: Estabelecer uma correlação da topografia tumoral e edema peritumoral com a resposta terapêutica à administração intranasal do álcool perílico (AP) em pacientes com glioblastoma (GBM) recidivo após tratamento convencional. Métodos: A coorte incluiu o estudo retrospectivo de 119 pacientes com glioma recidivo, sendo 52 em tratamento paliativo de suporte (grupo controle não pareado) e 67 que foram incluídos no Estudo Fase I/II do álcool perílico e receberam administração pela via inalatória de 440 mg de AP diariamente durante o período de Janeiro 2005 a Dezembro 2009. Os parâmetros avaliados incluíram aspectos clínicos e de neuroimagem: topografia tumoral, volume tumoral, presença de desvio da linha média e extensão de edema peritumoral; análise dos dados demográficos, sintomas iniciais e sobrevida global. Análise estatística foi realizada usando testes log rank. A sobrevida global foi determinada pelo método de Kaplan-Meier, incluindo intervalos de confiança de 95%. Resultados: Pacientes do grupo controle apresentaram sobrevida reduzida (p < 0,0001) em relação ao grupo tratado com AP. Dentre os 67 pacientes com GBM, 14 (21%) apresentavam localização talâmica e 53 (79%) localização lobar. Pacientes com tumor localizado na região do tálamo sobreviveram significativamente mais tempo do que aqueles com tumor localizado na região lobar (log rank test, p = 0,0003). Pacientes que apresentaram regressão tumoral acompanhada de redução do edema peritumoral apresentaram resposta clínica positiva, enquanto aqueles com regressão tumoral sem redução do edema peritumoral apresentaram evolução clínica desfavorável, independentemente da topografia tumoral. Presença de desvio da linha média (> 1 cm) foi estatisticamente significante como fator de risco para menor sobrevida (log rank test, p = 0,0062). Conclusões: Este estudo sugere que: (1) pacientes com tumor localizado na região profunda (tálamo) apresentaram sobrevida média maior do que pacientes com tumor localizado na região lobar; (2) edema peritumoral foi um fator determinante na sintomatologia, provavelmente implicado na morbidade podendo estar relacionado com a característica de invasividade do glioma maligno. Esses achados apóiam a teoria de que fatores presentes em diferentes microambientes do tecido cerebral (tálamo, córtex) possam contribuir para o processo de progressão tumoral, para o prognóstico clínico e a resposta terapêutica ao álcool perílico administrado pela vias inalatória
Introduction: Gliomas are primary brain tumors are characterized by diffuse and invasive growth. Study biomathematical proliferation and migration of gliomas suggests that the growth of tumors in deep brain gray matter would have a longer time interval compared with lesions in the lobar white matter, where the invasion and migration would be faster. Objective: To establish a correlation of peritumoral edema and tumor topography with the therapeutic response to intranasal administration of perillyl alcohol (PA) in patients with glioblastoma (GBM) relapsing after conventional treatment. Methods: The cohort included a retrospective study of 119 patients with relapsing glioma, 52 palliative care support (control group) and 67 that were included in the Study Phase I / II and received perillyl alcohol administration by inhalation of 440 mg AP daily during the period January 2005 to December 2009. The parameters evaluated included clinical and neuroimaging: topography tumor, tumor volume, presence of midline shift and extent of peritumoral edema, analysis of demographic data, initial symptoms and overall survival. Statistical analysis was performed using log rank tests. Overall survival was determined by Kaplan-Meier, including 95% confidence intervals. Glioma is a primary brain tumor characterized by diffuse growth and invasiveness. The pattern of differential tumor growth and invasiveness suggest that patients with tumoral lesion located in the lobar white matter region present lower survival rate than patients with lesion located in deep brain gray matter (thalamo). Objective: To establish a correlation between tumor topography and peritumoral edema with the therapeutic response to intranasal administration of perillyl alcohol (POH). Methods: This retrospective study analyzed 119 patients with recurrent glioma being 52 under supportive treatment (control group) and 67 included in the Phase I/II clinical trial that received intranasal administration of 440 mg daily AP from January 2005 to December 2009. The following parameters were analyzed: clinical assessment; demographic data, symptoms and overall survival, neuroimage analysis of topography including tumor volume, midline shift and extent of peritumoral edema. Statistical analysis was performed using log rank tests. The overall survival was determined by the Kaplan-Meier method, including 95% confidence intervals. Results: Patients from control group showed reduced overall survival (p < 0,0001) in comparison with patients included in the Phase I/II that received treatment with perillyl alcohol. Among 67 GBM patients, 14 (21%) had tumoral lesion in the thalamic region and 53 (79%) in the lobar region. Patients with thalamic tumor survived significantly longer than those with tumor located in the lobar region (log rank test, p = 0.0003). Patients with tumor regression with reduction of peritumoral edema had positive clinical response, whereas poor prognosis was observed in those with tumor regression but without reduction of peritumoral edema. Presence of midline shift (> 1 cm) was statistically significant as a risk factor for shorter survival (log rank test, p = 0062). Conclusions: This study indicates that: 1) patients with tumoral lesion in the deep region (thalamic) have longer overall survival than GBM patients with tumors in the lobar region; 2) presence of peritumoral edema contributes strongly to symptoms and is likely to influence morbidity and the invading potential of malignant glioma. These findings support the hypothesis that interaction between glioma cells and different brain microenvironment (thalamo, cortex) can influence the process of glioma progression, clinical prognosis and therapeutic response to intranasal delivery perillyl alcohol
Grochot, Rafael Maciel. "Expressão do PD-L1 em neoplasias cervicais e seu impacto em sobrevida associado à infiltração linfocitária peritumoral e à expressão de FOXP3." reponame:Repositório Institucional da UCS, 2018. https://repositorio.ucs.br/11338/3902.
Повний текст джерелаMendes, Suzanny Oliveira. "Perfil da expressão de HIF-1α em células linfoides do infiltrado inflamatório peritumoral e intratumoral como marcador prognóstico do carcinoma epidermoide de cavidade oral". reponame:Repositório Institucional da UFES, 2014. http://repositorio.ufes.br/handle/10/1887.
Повний текст джерелаApproved for entry into archive by Patricia Barros (patricia.barros@ufes.br) on 2016-05-16T14:59:05Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Dissertacao Suzanny Oliveira Mendes.pdf: 1218162 bytes, checksum: ba406f76a90163a9319cfc83b966766b (MD5)
Made available in DSpace on 2016-05-16T14:59:05Z (GMT). No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Dissertacao Suzanny Oliveira Mendes.pdf: 1218162 bytes, checksum: ba406f76a90163a9319cfc83b966766b (MD5)
O complexo transcricional HIF-1 é responsável por controlar a transcrição de mais de 100 genes envolvidos em resposta celular a hipóxia. A subunidade HIF-1α é estabilizada em condições de hipóxia e dimeriza-se com um a subunidade HIF-1β, formando o complexo HIF-1 transcricionalmente ativo. Em células inflamatórias, uma elevada expressão de HIF-1α pode induzir os linfócitos à imunossupressão, reduzindo o reconhecimento dos antígenos tumorais, permitindo o crescimento tumoral. O presente trabalho objetivou investigar a relação entre a expressão de HIF-1α em linfócitos do infiltrado inflamatório intratumoral e peritumoral de 56 pacientes com carcinoma epidermoide de cavidade oral. Os resultados indicaram um valor prognóstico para esta expressão. Uma elevada expressão da HIF-1α em células do infiltrado inflamatório peritumoral foi significantemente relacionada com o pior prognóstico do paciente, enquanto esta elevada expressão nos linfócitos na região intratumoral foi correlacionado com um melhor prognóstico. Um perfil de risco indicando a chance para a recidiva e óbito foi desenhado baseado na expressão de HIF-1α nos linfócitos do infiltrado inflamatório peritumoral e intratumoral, definindo os riscos baixo, intermediário e alto. Este perfil de risco foi hábil para determinar que a expressão forte de HIF-1α nos linfócitos peritumorais são relacionados com um pior prognóstico, independente da expressão nas células intratumorais. A expressão fraca de HIF-1α nos linfócitos peritumorais e forte nos linfócitos intratumorais foram considerados um perfil de baixo risco, mostrando nenhum caso de recidiva da doença e óbito decorrente da doença. O risco intermediário foi associado com baixa expressão de HIF-1α tanto em infiltrado inflamatório intratumoral como peritumoral. Estes resultados sugerem que a expressão da HIF-1α em células linfoides do infiltrado inflamatório intratumoral e peritumoral pode exercer um papel importante como um marcador prognóstico tumoral.
The HIF-1 transcriptional complex is responsible for controlling transcription of over 100 genes involved in cell hypoxia response. HIF-1α subunit is stabilized in hypoxia conditions, dimerizes with HIF-1β forming the active HIF-1 transcriptional factor. In inflammatory cells, high HIF-1α expression might induce lymphocytic immunosuppression, decreasing tumoral antigen recognition, allowing tumor growth. The present work aimed to investigate the relationship between HIF-1α expression in lymphocytes inflammatory infiltrate from intratumoral and peritumoral region of 56 patients with oral cancer. Data indicates a prognostic value for this expression. High HIF-1α expression in peritumoral inflammatory cells was significantly related to worse patient outcome, whereas high expression in the intratumoral lymphoid cells correlates with a better prognosis. A risk profile indicating the chance of disease relapse and death was designed based on HIF-1α expression in inflammatory infiltrate cells, defining low, intermediate and high risks. This risk profile was able to determine that high HIF-1α expression in peritumoral lymphocytes correlates with worse prognosis, independently of intratumoral inflammatory infiltrate expression. Low HIF-1α in peritumoral lymphocytes and high expression in the intratumoral lymphocytes was considered a low risk profile, showing no cases of disease relapse and disease related death. Intermediate risk was associated with low HIF-1α expression in inflammatory infiltrate intratumoral and peritumoral. in tumor and tumor margins. These results suggest that HIF-1α expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker.
MENDES, S. O. "Perfil da Expressão de Hif-1 Alfa em Células Linfoides do Infiltrado Inflamatório Peritumoral e Intratumoral Como Marcador Prognóstico do Carcinoma Epidermoide de Cavidade Oral." Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/4481.
Повний текст джерелаO complexo transcricional HIF-1 é responsável por controlar a transcrição de mais de 100 genes envolvidos em resposta celular a hipóxia. A subunidade HIF-1α é estabilizada em condições de hipóxia e dimeriza-se com um a subunidade HIF-1β, formando o complexo HIF-1 transcricionalmente ativo. Em células inflamatórias, uma elevada expressão de HIF-1α pode induzir os linfócitos à imunossupressão, reduzindo o reconhecimento dos antígenos tumorais, permitindo o crescimento tumoral. O presente trabalho objetivou investigar a relação entre a expressão de HIF-1α em linfócitos do infiltrado inflamatório intratumoral e peritumoral de 56 pacientes com carcinoma epidermoide de cavidade oral. Os resultados indicaram um valor prognóstico para esta expressão. Uma elevada expressão da HIF-1α em células do infiltrado inflamatório peritumoral foi significantemente relacionada com o pior prognóstico do paciente, enquanto esta elevada expressão nos linfócitos na região intratumoral foi correlacionado com um melhor prognóstico. Um perfil de risco indicando a chance para a recidiva e óbito foi desenhado baseado na expressão de HIF-1α nos linfócitos do infiltrado inflamatório peritumoral e intratumoral, definindo os riscos baixo, intermediário e alto. Este perfil de risco foi hábil para determinar que a expressão forte de HIF-1α nos linfócitos peritumorais são relacionados com um pior prognóstico, independente da expressão nas células intratumorais. A expressão fraca de HIF-1α nos linfócitos peritumorais e forte nos linfócitos intratumorais foram considerados um perfil de baixo risco, mostrando nenhum caso de recidiva da doença e óbito decorrente da doença. O risco intermediário foi associado com baixa expressão de HIF-1α tanto em infiltrado inflamatório intratumoral como peritumoral. Estes resultados sugerem que a expressão da HIF-1α em células linfoides do infiltrado inflamatório intratumoral e peritumoral pode exercer um papel importante como um marcador prognóstico tumoral.
Makdissi, Fabiana Baroni Alves. ""Análise da expressão de E-caderina, Snail e Hakai em células epiteliais de tumor e tecido peritumoral de mulheres com carcinoma ductal invasivo da mama: correlação com comprometimento linfonodal"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-07082006-110753/.
Повний текст джерелаE-cadherin (Ecad) expression may be transcriptionally or post-transcriptionally regulated by Snail and Hakai. Our aim was to determine the expression of Ecad, Snail and Hakai, in epithelial cells (EC) obtained from tumor and its adjacent tissue from women with invasive ductal breast carcinoma (IDC) and evaluate their correlation to the axillary's lymph node (LN+) involvement. Tissue from 45 patients (52% LN+) had their EC recovered by immunomagnetic antibody process, RNA was extracted and real-time RT-PCR was performed using specific primers. Ecad, Snail and Hakai mRNA expression did not vary between tumoral and peritumoral samples and their expression was not correlated to LN involvement
GIANNICE, RAFFAELLA. "Il microambiente peritumorale nel carcinoma dell'endometrio." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/31294.
Повний текст джерелаLemée, Jean-Michel. "Au delà des frontières du glioblastome : caractérisation de la zone péritumorale des glioblastomes." Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0001/document.
Повний текст джерелаGlioblastoma (GB) is a heterogeneous andaggressive tumor, before which therapeutic options arelimited. The study of the macroscopically normalperitumoral brain zone (PBZ) of GB is essential tounderstand its mechanisms of progression andrecurrence.The first objective of this thesis work was tocompare the transcriptomic and proteomic data from theGB tumor area obtained through the “Grand Ouest”glioma Project. The concordance rate between the 2modalities is low. However, one of the common featureis the dysregulation of neurofilament light polypeptide,which could serve as a biomarker potential of GB.The second objective of this thesis was thecharacterization of the PBZ. We have shown that thisarea, similar at first glance to that of healthy braintissue, is not a simple transition area between the GBand healthy brain tissue but a specific entity withcharacteristics of its own. For example, the ZMNpresents a particular phenotype of infiltrating GB cellsand stromal cells and a surexpression of CRYAB andH3F3A proteins.This thesis work was also an opportunity todevelop new intraoperative imaging techniques of thePBZ, with the aim to assess the presence of a tumoralinfiltration and optimize the quality of the surgicalresection.The characterization of this PBZ allows us tobetter understand its involvement in tumorigenesis andthe presence of specific characteristics of this areaopens the door for the detection of specific biomarkersand the development of targeted therapies.This thesis work was led to 2 publications, 2articles submitted and a patent being evaluated andredacted by a patent office
Sarraf, Michel. "Evaluation non-invasive des Gliomes par Imagerie Résonance Magnétique : Effets des traitements anti-angiogéniques (Avastin) sur la microvascularisation et la microarchitecture tumorale et péritumorale." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAS040.
Повний текст джерелаIn neuro-oncology, the effects of anti-angiogenic treatments are not predictable, as observed in glioblastomas treated with Avastin. Only a minority of patients show a significant response to treatment. Conventional imaging modalities are not able to evaluate the efficiency in the early phase of the treatment. Thus, the challenge remains to find and to validate new biomarkers that are able to predict the early response to such therapies.The aim of this work is to develop and implement a preclinical multiparametric magnetic resonance imaging (MRI) protocol for the characterization and follow up of early microvascular and microstructural changes in the tumor and its peritumoral regions after treatment with Avastin. For this purpose, the quantification of the blood volume and Kmodel (an apparent coefficient that is related to the contrast agent (CA) uptake rate), and evaluation of brain microarchitecture by diffusion tensor imaging were developed and evaluated as biomarkers.The Rapid Steady State T1 (RSST1) method was initially developed for blood volume quantification in the absence of CA extravasation. In the first part of this thesis, we have implemented and adapted this MRI technique for the quantification of both blood volume and Kmodel in tumors where the CA extravasates. We developed a mathematical model for the RSST1 signals that accounts for the unidirectional bi-compartmental exchange of CA from the vascular towards the extravascular compartment. This development allows to the quantification of vascular parameters in a rat glioma model (C6). The results were confirmed using another MRI modality, the steady state magnetic susceptibility method, and quantitative histology.In the second part, we studied the sensitivity of the RSST1 method for the follow up of the glioma response to anti-angiogenic treatment under clinical conditions. In this study, the effect of Avastin treatment in a murine orthotopic U87 MG glioma model was analyzed. The RSST1 method demonstrated a high reproducibility in the blood volume quantification and a superior sensitivity in comparison to CA enhanced T1-weighted imaging (T1W-Gd-DOTA) for the detection and follow-up of the tumor response to Avastin, especially in early stages of tumor progression. Blood volume quantification by MRI was correlated to measures obtained by two-photon microscopy.In the last part of this thesis, we have studied the capacity of diffusion tensor imaging (DTI) coupled with FLAIR (fluid-attenuated inversion recovery) MRI and T1w-Gd-DOTA, to characterize tumor, peritumoral, and contralateral regions of the U87MG glioma model. We quantified DTI parameters before and during the invasion of tumor cells induced by Avastin in the peritumoral zone for different administration modes: intravenous and intratumoral via Convention-Enhanced Delivery. Therefore, the delineation of peritumoral regions for each tumor in an early stage was based on anatomical images, that took into account the individual tumor progression at later stages. Significant differences were detected for DTI parameters between the tumor, peritumoral, and contralateral regions and a different evolution of these parameters was noticed according to the Avastin injection mode
Книги з теми "Peritumoral"
Cherdanceva, Tat'yana, Vladimir Klimechev, and Igor' Bobrov. Pathological and molecular biological analysis of renal cell carcinoma. Diagnosis and prognosis. ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1020785.
Повний текст джерелаHatef, Jeffrey, and Russell R. Lonser. Hemangioblastoma. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0007.
Повний текст джерелаWoolf, Eric C., and Adrienne C. Scheck. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer. Edited by Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0013.
Повний текст джерелаЧастини книг з теми "Peritumoral"
Chang, Han Soo. "Peritumoral Edema." In Meningiomas, 565–71. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84628-784-8_60.
Повний текст джерелаBradač, Gianni Boris, Ron Ferszt, and Brian E. Kendall. "Peritumoral Oedema in Meningiomas." In Cranial Meningiomas, 120–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-72581-4_13.
Повний текст джерелаKawamura, Atsufumi, T. Nagashima, K. Fujita, and N. Tamaki. "Peritumoral Brain Edema Associated with Pediatric Brain Tumors: Characteristics of Peritumoral Edema in Developing Brain." In Brain Edema IX, 381–83. Vienna: Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_103.
Повний текст джерелаGröger, U., P. Huber, and H. J. Reulen. "Formation and Resolution of Human Peritumoral Brain Edema." In Brain Edema IX, 373–74. Vienna: Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_100.
Повний текст джерелаIde, Mitsunobu, M. Jimbo, O. Kubo, M. Yamamoto, E. Takeyama, and H. Imanaga. "Peritumoral Brain Edema and Cortical Damage by Meningioma." In Brain Edema IX, 369–72. Vienna: Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_99.
Повний текст джерелаGutwald, J., W. Groth, and G. Mahrle. "Erste Ergebnisse mit peritumoral injiziertem I1-2 beim Melanom." In Operative Dermatologie, 65–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79468-1_12.
Повний текст джерелаShirotani, Toshiki, K. Shima, and H. Chigasaki. "Resolution of Peritumoral Brain Edema Following Excision of Meningioma." In Brain Edema IX, 416–18. Vienna: Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_113.
Повний текст джерелаIto, Umeo, H. Tomita, O. Tone, H. Masaoka, and B. Tominaga. "Peritumoral Edema in Meningioma: a Contrast Enhanced CT Study." In Brain Edema IX, 361–64. Vienna: Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_97.
Повний текст джерелаOuld Ismail, Abdol Aziz, Drew Parker, Moises Hernandez-Fernandez, Steven Brem, Simon Alexander, Ofer Pasternak, Emmanuel Caruyer, and Ragini Verma. "Characterizing Peritumoral Tissue Using DTI-Based Free Water Elimination." In Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, 123–31. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11723-8_12.
Повний текст джерелаIkeda, Y., and S. Nakazawa. "Peritumoral Edema: Analysis of CT Scan and Dynamic CT Scan." In Brain Edema, 479–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70696-7_72.
Повний текст джерелаТези доповідей конференцій з теми "Peritumoral"
Campos, Ingrid, Paulo de Aguiar, Ingrid Campos, Cassiano Marchi, and Fábio Nakazone. "Edema cerebral peritumoral em glioblastoma." In XXXII Congresso Brasileiro de Neurocirurgia. Thieme Revinter Publicações Ltda, 2018. http://dx.doi.org/10.1055/s-0038-1672376.
Повний текст джерелаYashin, Konstantin S., Ksenia A. Achkasova, Alexander A. Moiseev, Elena B. Kiseleva, Evgenia L. Bederina, Anna A. Epishkina, Anton Y. Ermolaev, Igor A. Medyanik, Elena V. Zagaynova, and Natalia D. Gladkova. "Quantification of peritumoral white matter damage using cross-polarization OCT." In Clinical and Translational Neurophotonics 2021, edited by Victor X. D. Yang and Jana M. Kainerstorfer. SPIE, 2021. http://dx.doi.org/10.1117/12.2578274.
Повний текст джерелаPilones, Karsten, Silvia Formenti, and Sandra Demaria. "Abstract 1416: Peritumoral IL-15 potentiates radiation-induced anti-tumor immunity." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1416.
Повний текст джерелаKarwat, Piotr, Ziemowit Klimonda, Hanna Piotrzkowska-Wroblewska, Katarzyna Dobruch-Sobczak, and Jerzy Litniewski. "Quantitative ultrasound examination of peritumoral tissue improves classification of breast lesions." In 2019 IEEE International Ultrasonics Symposium (IUS). IEEE, 2019. http://dx.doi.org/10.1109/ultsym.2019.8925988.
Повний текст джерелаTrivedi, Megh, Alankrita Raghavan, Paramita Das, Pablo Recinos, and Varun Kshettry. "Peritumoral Edema and Surgical Outcome in Secretory Meningiomas: A Matched Cohort Analysis." In 29th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1679459.
Повний текст джерелаPapadas, Athanasios, Alexander Cicala, Alejandro Rizo, Chelsea Hope, Katerina Politi, Christian Capitini, Kristina Matkowskyj, Scott Abrams, and Fotis Asimakopoulos. "981 Peritumoral stromal remodeling licenses cDC1 through CD40 to elicit T-cell inflammation." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0981.
Повний текст джерелаWilliams, T., E. Roman-Perez, JL Rein, KD Amos, and MA Troester. "P1-03-07: Subtype-Specific Gene Expression Signatures in Peritumoral Non-Neoplastic Breast Tissue." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p1-03-07.
Повний текст джерелаRao, Manasa G., Travis R. Ladner, William H. Shuman, Rui Feng, Johanna T. Fifi, Reade A. D. Leacy, J. Mocco, and Raj Shrivastava. "Safety and Efficacy of Preoperative Embolization of Meningioma in Patients with Preoperative Peritumoral Edema." In Special Virtual Symposium of the North American Skull Base Society. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1725490.
Повний текст джерелаRathore, Saima, Hamed Akbari, Martin Rozycki, Michel Bilello, Robert A. Lustig, Christos A. Davatzikos, Jimit Doshi, and Gaurav Shukla. "Technical note: a radiomic signature of infiltration in peritumoral edema predicts subsequent recurrence in glioblastoma." In Image-Guided Procedures, Robotic Interventions, and Modeling, edited by Robert J. Webster and Baowei Fei. SPIE, 2018. http://dx.doi.org/10.1117/12.2323331.
Повний текст джерелаSebiskveradze, David, Cyril Gobinet, Nathalie CARDOT-LECCIA, Jean-Paul ORTONNE, Michel MANFAIT, Pierre JEANNESSON, and Olivier PIOT. "Abstract 4052: Highlighting intratumoral heterogeneity and peritumoral areas in human melanoma biopsies by infrared spectral microimaging." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4052.
Повний текст джерела