Дисертації з теми "Periodontitis; omega-3; fish oil"
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Rodrigues, Ana Sofia de Figueiredo. "Industrial production of omega-3 polyunsaturated fatty acids from fish oil and microalgae." Master's thesis, ISA/UTL, 2012. http://hdl.handle.net/10400.5/5257.
Повний текст джерелаω-3 polyunsaturated fatty acids (PUFAs) ingredients, especially eicosapentaenoic acid (EPA, 20:5ω3) and docosahexaenoic acid (DHA, 22:6ω3) are known for its vital and unique role in human health and well-being by an extensive scientific research. These facts are widely spread by media. At present, the major source of ω-3 PUFAs is fish oil from oily fish like sardine (Sardina pilchardus). This work proposes the use of heterotrophic microalgae such as Crypthecodinium cohnii as an alternative source of interest for the commercial production of ω-3 EPA and DHA. It is also suggested the use of a common process suitable for both feedstock. EPA and/or DHA production are accomplished through oil saponification and PUFAs concentration winterization and urea concentration. PUFAs purification by chromatography is only necessary when oil is extracted from fish since fractions obtained from C. cohnii have high proportions in DHA and they do not require further purification steps for food applications. The combination of traditional (seasonal) and alternative sources (year-round) using a common production process shows an economic advange with increasing earnings for market development.
Gruenfelder, Catherine A. "Sensory evaluation of heart-healthy foods enriched with omega-3 fats from fish oil." Thesis, College of Saint Elizabeth, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1555163.
Повний текст джерелаA diet rich in omega-3 fats has been shown to reduce the risk of cardiovascular disease. Long chain omega-3 fats found in fatty fish are especially important to cardiovascular health. Consumption of these fats is low, in part because there are few natural sources. This has led to the development of omega-3 fortified foods. Currently available fortified foods demonstrate conflicting nutritional information. Addition of omega-3 fats to an otherwise unhealthy food is perceived by consumers as an advertising gimmick. Mistrust of food companies and confusing ingredient labels negatively impact sales. Careful nutritional guidance, combined with proper sensory analysis, is critical to developing omega-3 fortified food products that are consistent with medical recommendations. Results from this study indicate that a therapeutic dose of fish oil (1000 mg per serving) can be added to two heart-healthy foods without adversely affecting sensory qualities.
Soewono, Adri A. "Blending palm oil with flaxseed oil or menhaden fish oil to produce enriched omega-3 oils for deep-fat-frying." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/32399.
Повний текст джерелаLand and Food Systems, Faculty of
Graduate
Smith, Bryan K. "Exercise and fish oil : additive effect on postprandial lipemia? /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074443.
Повний текст джерелаHolmes-Miller, Leah. "The Effect of Supplementing Grazing Dairy Cattle Diets with Fish Oil and Linseed Oil on Milk CLA and Omega-3 Fatty Acid Content." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1885462201&sid=2&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерелаBrown, William. "Effects of supplementing grazing dairy cows with fish oil and linseed oil on milk conjugated linoleic acid and omega-3 fatty acids content /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1456286001&sid=2&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерелаHannah, Sabrina. "Microencapsulation of an omega-3 polyunsaturated fatty acid source with polysaccharides for food applications." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/29525.
Повний текст джерелаPh. D.
Fernández, Castaño Irene. "Efecto de la administración de ácido docosahexanóico sobre las alteraciones metabólicas y sobre la distribución de grasa corporal en pacientes con infección por VIH-1 sometidos a tratamiento antiretroviral." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399575.
Повний текст джерелаBackground. Hypertriglyceridemia is common in HIV-infected patients. Omega-3 fatty acids reduce fasting serum triglyceride (TG) levels in HIV-infected patients. It is not known whether docosahexanoic acid (DHA) supplementation can reduce hypertriglyceridemia and modify fat distribution in HIV-infected patients. Methods. We conducted a randomized, double-blind, placebo-controlled trial with 84 antiretroviral-treated patients who had fasting TG levels from 2.26-5.65 mmol/l and were randomized to receive DHA or placebo for 48 weeks. TG levels were assessed at baseline, week 4 and every 12 weeks. Body composition was assessed at baseline and at week 48. And systemic inflammatory and molecular SAT markers were assessed at baseline and at week 48 in a subgroup of 39 patients. This study is registered with ClinicalTrials.gov, NCT02005900. Results. Patients receiving DHA had a 43.9% median decline in fasting TG levels at week 4 (IQR: -31% to -56%), compared with -2.9% (-18.6% to 16.5%) in the placebo group (P < 0.0001). There was a significant correlation between DHA levels and decrease in TG at week 4 in the DHA arm (r = 0.7110, P < 0.0001). By week 12, the median reduction in TG levels in the DHA arm was -43.7% (-32.4% to -57.5%), and in the placebo arm +2.9% (-21.3% to +30.1%). The difference between study arms remained statistically significant at week 48 (P = 0.0253). Low-density lipoprotein cholesterol levels had significantly increased at week 4 by 7.1% (IQR: -4.8% to +35.3%) in the DHA arm but not in the placebo group. No significant changes were observed in HDL cholesterol, insulin, and HOMA-IR during the study. Limb fat significantly increased in both arms, without statistically significant differences between groups (P = 0.3889). High sensitivity C reactive protein (hsCRP) and arachidonic acid levels significantly decreased in the DHA group. Adipogenesis-related genes (PPAR-γ, adiponectin) and mitochondrial-related gene expression did not experience significant changes in either group. Mitochondrial DNA (mtDNA) significantly decreased in the placebo group. SAT inflammation-related gene expression (TNF-α, MCP-1) significantly decreased in the DHA but remained unaltered in the placebo group. DHA was well tolerated; only 3 patients experienced treatment-limiting toxicity. Conclusions Supplementation with DHA reduced fasting TG levels in antiretroviral-treated HIV-infected patients with mild hypertriglyceridemia. DHA was well tolerated with minor GI symptoms. Peripheral fat significantly increased in the DHA group but did not increase significantly compared with placebo. DHA supplementation down-regulated inflammatory gene expression in SAT, but did not modify adipogenesis-related gene expression. DHA impact on markers of systemic inflammation was restricted to a significant decrease in hsCRP and arachidonic acid.
Ramakrishnan, Sarathiraja. "Encapsulation of omega-3 fatty acids by premix membrane emulsification." Doctoral thesis, Universitat Rovira i Virgili, 2013. http://hdl.handle.net/10803/145770.
Повний текст джерелаEl aceite de pescado es altamente valorado en la industria alimentaria por su demostrada actividad en la prevención y tratamiento de numerosas patologías, asociada a su contenido en ácidos grasos omega-3. La incorporación de aceite de pescado en alimentos presenta algunas dificultades relacionadas con su rápida oxidación y su característico aroma y sabor. La encapsulación del aceite de pescado retrasa la oxidación y permite enmascarar sus propiedades sensoriales. Tradicionalmente, la encapsulación se lleva a cabo combinando una etapa de emulsificación seguida de secado por atomización. El objetivo principal del trabajo es estudiar el efecto del método de emulsificación y la formulación de la emulsión y las microcápsulas en los parámetros físico-químicos más relevantes de las microcápsulas. En este proyecto se combina por primera vez la emulsificación por membranas con el secado por atomización para obtener microcápsulas de aceite de pescado aplicables a la industria alimentaria. Los resultados muestran una clara mejora en la eficiencia de encapsulación del aceite cuando se reduce el tamaño de gota de la emulsión y se incrementa la cantidad de material de pared de las microcápsulas. La combinación de un polisacárido con una proteína para la formación de la pared mejora la estabilidad oxidativa de las microcápsulas durante el almacenamiento. Por otra parte la adición de proteínas desnaturalizadas para reforzar las paredes de las microcápsulas ha resultado en una mejora de la eficiencia de encapsulación de aceite pero no ha mejora su resistencia mecánica
Jensen, Maren T. "Effects of A-beta immunotherapy and Omega-3 fatty acid administration in Alzheimer's transgenic mice." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001438.
Повний текст джерелаJaritkhuan, Somtawin. "Thraustochytrids as a food source in aquaculture." Thesis, University of Portsmouth, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343334.
Повний текст джерелаMcDaniel, J., Karen A. Massey, and Anna Nicolaou. "Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds." Wiley, 2010. http://hdl.handle.net/10454/4577.
Повний текст джерелаChronic wounds often result from prolonged inflammation involving excessive polymorphonuclear leukocyte activity. Studies show that the omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids found in fish oils generate bioactive lipid mediators that reduce inflammation and polymorphonuclear leukocyte recruitment in numerous inflammatory disease models. The purpose of this study was to test the hypotheses that boosting plasma levels of eicosapentaenoic and docosahexaenoic acids with oral supplementation would alter lipid mediator levels in acute wound microenvironments and reduce polymorphonuclear leukocyte levels. Eighteen individuals were randomized to 28 days of either eicosapentaenoic + docosahexaenoic acid supplementation (Active Group) or placebo. After 28 days the Active Group had significantly higher plasma levels of eicosapentaenoic (p<0.001) and docosahexaenoic acid (p<0.001) than the Placebo Group and significantly lower wound fluid levels of two 15-lipoxygenase products of omega-6 polyunsaturated fatty acids, [9- hydroxyoctadecadienoic (HODE) acid (p = 0.033) and15-hydroxyeicosatrienoic acid (HETrE) (p = 0.006)], at 24 hours post wounding. The Active Group also had lower mean levels of myeloperoxidase, a leukocyte marker, at 12 hours and significantly more re-epithelialization on Day 5 post wounding. We suggest that lipid mediator profiles can be manipulated by altering polyunsaturated fatty acid intake to create a wound microenvironment more conducive to healing.
Arshad, Ali. "Phase II trial of the effect of gemcitabine with intravenous omega-3 fish oil infusion in patients with unresectable pancreatic adenocarcinoma." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28133.
Повний текст джерелаHarvey, Jessica C. "The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125476.
Повний текст джерелаBurkey, Carren Nyambare. "Bioprocessing of soybean seed-coats for production of proteins & omega-3 fatty acids using Pythium isolates." Bowling Green State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu159361093538274.
Повний текст джерелаConto, Leilane Costa de 1984. "Production of microcapsules containing fish oil omega-3 polyunsatureted fatty acid ethyl esters = Produção de microcápsulas contendo éster etílico de ácidos graxos polinsaturados ômega-3 de óleo de peixe." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/255088.
Повний текст джерелаTexto em português e inglês
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
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Resumo: Óleos e gorduras são importantes na alimentação humana como fonte de energia,além de alguns serem considerados essenciais ao funcionamento dos organismos, tais como determinados ácidos graxos polinsaturados ômega-3. O ácido eicosapentaenóico (EPA) e o ácido docosahexaenóico (DHA), provenientes de fontes marinhas, são as principais formas de ingestão direta de ômega-3,porém estes são muito sensíveis à oxidação e apresentam flavors característicos que levam à rejeição por alguns consumidores. Uma alternativa para contornar estes problemas é a microencapsulação. Uma técnica muito difundida para este tipo de produto sensível é a coacervação, no entanto algumas novas técnicas vêm surgindo na busca de solução destas deficiências. A gelificação enzimática pode ser citada como uma nova tecnologia que objetiva reduzir algumas etapas do processo e tempo de produção, se comparado ao processo de coacervação.Neste trabalho buscou-se compreender o comportamento do material de recheio (éster etílico de óleo de peixe), visto que são encontrados poucos estudos referentes às análises da integridade dos materiais de recheio de natureza lipídica quando encapsulados, e dos materiais de parede (principalmente isolado protéico de soja e isolado protéico de soro) quando utilizados para a produção de microcápsulas por gelificação enzimática e por coacervação complexa, avaliando tanto as cargas eletrostáticas do meio pelo seu potencial zeta para a coacervação, quanto na caracterização completa das cápsulas produzidas por gelificação enzimática e coacervação. Entre os materiais de parede estudados, foram utilizados isolado protéico de soro e isolado protéico de soja, sendo que este último na concentração de 10% apresentou formação de microcápsulas com características superiores pela técnica de gelificação enzimática. Quando estudadas mais a fundo as características das microcápsulas produzidas por gelificação enzimática, a ánalise do material encapsulado constatou-se que ocorreu a encapsulação de óleo de milho da segunda emulsão, reduzindo assim a eficiência real de encapsulação, mostrando-se assim uma técnica não eficaz,mesmo se obtendo cápsulas com elevada resistência mecânica. Comparando-se os métodos de degradação destas cápsulas, foi observada a total degradação da parede para a metodologia de degradação ácida, e parcial para a metodologia de degradação enzimática alcalina. Entretanto a melhor metodologia de degradação para se determinar a composição do material encapsulado foi a degradação ácida com determinação direta da composição em ácidos graxos. No estudo estatístico de microcápsulas contendo éster etílico de óleo de peixe produzidas por coacervação complexa utilizando isolado protéico de soja e goma arábica como material de parede obteve-se cápsulas contendo mais de 20 g de EPA + DHA / 100 g microcápsulas, sendo necessária a adição de menos de 0,5 g de microcápsulas em porções de 100 g ou 100 mL de alimentos para este poder ser considerado funcional. Contudo, uma grande variação no processo foi observadalevando a um estudo mais aprofundado do processo de coacervação através do potencial zeta dos materiais de parede e de recheio separadamente e em diferentes misturas, onde foi constatado que o isolado protéico de soja, por possuir variação na sua constituição e baixa solubilidade, dificulta a determinação exata do potencial zeta zero das misturas, sendo a máxima eficiência de encapsulação encontrada quando as misturas de 1,5:1,0 (massa:massa) isolado protéico de soja:Goma arábica e 2,0:1,0 (massa:massa) material de parede:material de recheio em pH 4,0 foram testados
Abstract: Fats and oils are important energy sources in human feeding, and some, such as the omega-3 polyunsaturated fatty acids, are considered essential to the functioning of the organisms. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids from marine sources are the principal forms used for the direct ingestion of omega-3, but are highly sensitive to oxidation and present characteristic flavors leading to their rejection by some consumers. One alternative to overcome these problems is microencapsulation, and one well known technique for this type of sensitive product is coacervation, although some new techniques are currently appearing which also attempt to overcome these deficiencies.Enzymatic gelation could be cited as a new technology which aims to reduce some of the processing steps and production time when compared to coacervation. This work aimed to understand the behavior of the core material (fish oil ethyl ester),since few studies can be found referring to analyses of the integrity of the core materials of a lipid nature when encapsulated, and of the wall materials (principally soy protein isolate and whey protein isolate), when used in the production of microcapsules by enzymatic gelation and by complex coacervation, evaluating both the electrostatic charges in the medium from their zeta potential for coacervation, and a complete characterization of the resulting capsules produced by both enzymatic gelation and coacervation. Of the wall materials studied, whey protein isolate and soy protein isolate were used, the latter, at a concentration of 10%, producing microcapsules with the best characteristics by the enzymatic gelation technique. However, when the characteristics of the microcapsules produced by enzymatic gelation were studied at greater depth, the analysis of the core material showed that lipid material from another source had been coencapsulated due to the processing conditions, thus reducing the true efficiency of the encapsulation, showing that this technique was not efficient, despite the elevated mechanical resistance of the microcapsules. A comparison of the methods used to degrade the capsules showed total degradation of the wall by the acid degradation methodology, and only partial degradation for the enzymatic alkaline degradation methodology. Thus the best degradation methodology to determine the composition of the encapsulated material was acid degradation with the direct determination of the fatty acid composition. In the statistical study of the production of microcapsules containing fish oil ethyl ester by complex coacervation using soy protein isolate and gum Arabic as the wall materials, capsules were obtained containing more than 20 g EPA + DHA / 100 g of microcapsules, requiring the addition of less than 0.5 g of microcapsules to 100 g or 100 mL portions of foods for the food to be considered functional. However considerable process variation was observed, leading to a study in greater depth of the coacervation process as from the zeta potential of the wall and core materials separately, and in different mixtures. Thus it was shown that the soy protein isolate presented variation in its constitution and low solubility, which made it difficult to determine the exact zero zeta potential of the mixtures, the maximum encapsulation efficiency being found with mixtures of 1.5:1.0 (w:w) soy protein isolate: gum Arabic as the wall material and a ratio of 2.0:1.0 (w:w) for the wall material: core material at pH 4.0
Doutorado
Tecnologia de Alimentos
Doutora em Tecnologia de Alimentos
Mori, Agnes Veridiana. "Utilização de óleo de peixe e linhaça na ração como fontes de ácidos graxos poliinsaturados ômega-3 em ovos de galinha." Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-16042013-134432/.
Повний текст джерелаTo investigate the effect of increasing levels of dietary flaxseed, combined or not with fish oil, upon fatty acid composition of eggs, 288 Babcock laying hens were used for a 9 week experimental period. Reproductive performance of hens, internal and external egg quality, egg flavor, and yolk cholesterol levels were evaluated. The experiment had a 2X6 factorial design, hens were fed a basal diet (without animal products) supplemented with ground flaxseed (0%, 7%, 14%,21%,28% and 35%), combined or not with fish oil (2%). Egg weight was significantly decreased (p<0,05) frem 21% dietary flaxseed, and from 14% when fish oil was added to the diet. In birds fed either 28% or 35% flaxseed, egg production was depressed, regardless of the addition of fish oil. Feeding diets containing both fat sources did not affect egg quality, and yolk cholesterol content (mg/g) was significantly increased in eggs laid by hens fed 35% flaxseed. Yolk concentrations of linolenic acid were enhanced as a result of feeding hens increasing levels of dietary flaxseed, and its deposition was markedly increased when fish oil was included in the diet. Yolk contents of EPA (eicosapentaenoic acid) were significantly increased when diets included 35% flaxseed, and the combination with fish oil produced enhanced levels of EPA from 7% dietary flaxseed. Egg contents of DHA (docosahexaenoic acid) were significantly increased from 7% dietary flaxseed, and the deposition of such n-3 fatty acid was greater when in combination with fish oil. Dietary fish oil and flaxseed caused a narrow ratio of n-6 to n-3 fatty acids, meeting the current dietary allowances. Regression equations allow to predict contents of linolenic acid, EPA, DHA, arachidonic acid, total of n-3 fatty acids and ratio of n-6 to n-3 in the yolk from levels of dietary flaxseed or linolenic acid. Fishy flavor was detected in eggs from hens fed 2% fish oil combined with flaxseed at 28 or 35%. In order to maximize the content of n-3, mainly the longer chain n-3 fatty acids, without impairing performance parameters and egg flavor, the combination of 2% fish oil and 7% flaxseed in the hen\'s diet is the most appropriate.
Schmidt, Mikki. "Effects of supplementing mare diets with marine-derived n-3 fatty acids on serum, follicular fluid and follicular dynamics during the estrous cycle." Thesis, Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/3898.
Повний текст джерелаCorrea, Ana Paula Antunes. "Fracionamento de oleo de peixe com dioxido de carbono supercritico." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256368.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
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Resumo: Os ácidos graxos polinsaturados ômega-3 (EPA, DHA) são compostos com propriedades terapêuticas no tratamento e prevenção de doenças coronárias, hipertensão, arteriosclerose e artrite, além de serem essenciais para o desenvolvimento e manutenção das funções do sistema nervoso central. Os óleos de peixes de origem marinha são as fontes mais ricas em ômega-3 e por isso têm sido usados com freqüência para a obtenção de concentrados destes ácidos graxos. A deficiência de ômega-3 na dieta da população causada pela baixa ingestão destes ácidos graxos, através do consumo de peixes, toma interessante o enriquecimento de alimentos mais populares como a margarina, pães e produtos lácteos com esses ácidos graxos. A extração com fluido supercrítico é um processo de separação relativamente novo que traz vantagens em relação às técnicas convencionais. Para alimentos, o dióxido de carbono tem sido o solvente mais empregado, por ser inerte, relativamente barato e não inflamável e por possuir pressão e temperatura crítica moderadas (304,15 K, 7,38 MPa), evitando problemas de degradação térmica. Neste trabalho, estudou se o fracionamento com dióxido de carbono supercrítico do óleo de peixe em diferentes condições de temperatura e pressão. Os experimentos foram realizados de 14,7 a 29,4 Mpa e de 301,15 a 323,15 K. O procedimento experimental consistiu em promover o contato entre o óleo de peixe aderido à esferas de vidro e o CO2 supercrítico, em um processo dinâmico, de forma a promover o equilíbrio de fases. O corpo do sistema permanecia imerso dentro de um banho termostatizado. O extrato do óleo de peixe (amostra da fase leve) foi coletado no final do extrator em condições de equilíbrio com a fa_e pesada e a sua composição em ácidos graxos foi determinada através de cromatografia em fase gasosa. A altas pressões (14,7 a 29,4 MPa), o extrato apresentou pouca diferença na sua composição em ácidos graxos em relação a fase pesada. A 7,8 MPa e 301,15 K um pequeno fracionamento foi obtido para o ácido docosahexaenóico (DHA). O ácido eicosapentaenóico (EPA) foi o ácido graxo que mostrou maior resistência ao fracionamento em todas as condições estudadas. Logo, neste estudo o dióxido de carbono supercrítico não se mostrou efetivo para o fracionamento do óleo de peixe rico em ácidos graxos polinsaturados. Estas dificuldades podem ser atribuídas à complexidade da composição do óleo de peixe em triacilgliceróis, os quais apresentam-se distribuídos em muitas frações com baixa porcentagem mássica no óleo e por serem formados por ácidos graxos de diferentes tamanhos de moléculas
Abstract: The omega-3 (EPA and DHA) polyunsaturated fatty acids are compounds with therapeutic properties, that may play an important role in the prevention and treatment of cardiovascular disease, hypertension, atherosclerosi, and arthriti. Furthermore, they are essencial for development and maintaince of central nervous system. Because there is a gap between intake of n-3 fatty acids by fish consumption and the recommended amount, it would be useful to enrich ordinary foods as margarine, bread and dairy foods with this fatty acids. The marine fish oils are the richest source of n-3 and it has been used as raw material for preparation of this fatty acid concentrate. Supercritical fluid extraction is a relatively new separation process that may circumvent some of the problems associated with the use of conventional separation techniques. In foods processes, carbon dioxide is the most used solvent, because it is inert, inexpensive and non-flamable and it has moderate critical temperature and pressure (304,15 K, 7,38 MPa), which avoid problems of thermo degradation. In the present work, the fractionation of fish oil with supercritical carbon dioxide at different conditions of temperature and pressure: pressure ranged from from 14,7 to 29,4 MPa and temperature ranged from 301,15 to 323,15 K. A known amount of fish oil was mixed with glass spheres and put inside the column extraction. The supercritical carbon dioxide was contacted with the fish oil in a dynamic system and the oil present in the light phase was collected in the end columm, which was in equilibrium conditions with the heavy phase. All the experimental body system was immersed in water bath to ensure isothermal conditions. The oil present in the light phase was trapped in a flask and its fatty acids composition was determined by gas phase chromatography. At higher pressures the extract obtained (Iight phase) showed similar composition in poliunsatured fatty acids when compared with heavy phase, so no fractionation effect was observed at this conditions. At 7,8 MPa and 301,15 K a modest fractionation was obtained for docosahexaenoic acid (DHA). The eicosapentaenoic acid (EPA) was the most difficult one to fraction at the studied conditions. So, in the present work, the supercritical carbon dioxide didn't show effective in the fractionation of fish oil rich in polyunsaturated fatty acids. This difficult can be explained by the complex composition of fish oil in triacylglicerols with different chain length fatty acids ligants and by similar molecular mass
Mestrado
Mestre em Engenharia de Alimentos
Roby, Mohamed Hussein Hamdy. "Synthèse et caractérisation de biomolécules antioxidantes." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0083/document.
Повний текст джерелаAn efficient solvent-free bioprocess was developed for the synthesis of DHA phenolic ester, using the lipase B from Candida antarctica. The protocol developed here led to high-level production (440 g/L) of DHA vanillyl ester (DHA-VE) that exhibits interesting application potential as food ingredient. DHA-VE was characterized by a high stability and a high radical scavenging activity towards DPPH, ABTS and hydroxyl radicals. Neuroprotective properties of DHA-VE were also demonstrated in rat primary neurons exposed to amyloid-[beta] oligomers. Enzymatic esterification of DHA with vanillyl alcohol (VA) led to increased DHA levels in erythrocytes and brain tissues of mice fed DHA-VE-supplemented diet comparing with DHA. No visible toxicity of the ester was found. Enrichment of emulsions with DHA-VE improved significantly their oxidative stability whatever the conditions of storage, showing the potential of DHA-VE to enrich various food matrices with DHA while protecting them against oxidation. The enzymatic process was applied to salmon oil as a source of omega-3 polyunsaturated fatty acids (PUFA). The total conversion of VA (50 g/L) was achieved after 24 h of reaction, leading to the production of a wide variety of esters that mirror the initial composition of the oil. The crude reaction medium recovered from salmon oil alcoholysis exhibited a high stability together with high antioxidant properties in comparison with native salmon oil. In conclusion, the approach that consists in bringing phenolic compounds and PUFA-rich lipids together within a single structure is expected to provide stable bioactive ingredients that should broaden the scope of application of omega-3 PUFAs whose health benefits are increasingly sought
Silva, Danielle Alves. "Comparação entre o óleo de peixe e de linhaça por via oral no tratamento de ceratoconjuntivite seca experimentalmente induzida em coelhos." Universidade do Oeste Paulista, 2014. http://bdtd.unoeste.br:8080/tede/handle/tede/316.
Повний текст джерелаThe keratoconjunctivitis sicca ( CCS ) , or dry eye, is a common chronic inflammatory eye disease in dogs and humans , which occurs due to deficiency of production of the aqueous portion of the tear film ( quantitative deficiency ) and / or excessive tear evaporation (disability qualitative ) , mainly affecting the cornea and conjunctiva may result in blindness . Treatment consists mainly in the use of tear substitutes as the use of immunosuppressive drugs (cyclosporine , tacrolimus and pimecrolimus ) (Stevenson et al , 2012) . Some studies in medicine and veterinary showed good results in controlling the CCS with the use of essential fatty acids (AGE ) , ω -3 and ω -6 , due to its ability to produce anti -inflammatory mediators ( BARABINO et al. 2003 , . NEVES et al , 2013 ) How fish oil and flaxseed oil are sources of AGE , but with differences in composition and concentration , and to the present time there is a comparative study of the efficacy of these compounds in the treatment of CCS . The objective of this study is to compare these two important sources of ω - 3 and ω - 6 , orally , in the treatment of experimentally induced in rabbits CCS .In order to compare the efficacy in the treatment of keratoconjunctivitis sicca ( CCS ) induced experimentally in rabbits , between two sources of omega 3 and 6 orally , fish oil ( FO) and linseed oil ( OL ) . We used 28 female rabbits of New Zealand breed , divided into 4 groups of 7 animals each : Group C (control ) , Group OP ( fish oil) , OL Group ( flaxseed oil ) and Group OPL ( Oil fish oil and flaxseed ) . The animals were evaluated by Schirmer Tear Test ( TLS ) , Rose Bengal Test ( TRB ) , Fluorescein test ( TF ) , Time Tear Film Break ( TRFL ) , ocular cytology and histopathology . The results showed a significant increase in the values of TLS and TRFL in all treatment groups , but this increase was earlier in the OP group . TRB in the performance of the groups was similar. With respect to the parameter TF , negative marking was delayed in group OPL . There was a significant decrease in the number of goblet cells in the OPL group in relation to other grupos.Os results showed that OL and OP orally improve the clinical signs of CCS , however this improvement was more rapid with the OP . The combined use of oils brought no additional benefit . These results can help in the future with new oral formulations useful in the adjuvant treatment of CCS .
A ceratoconjuntivite seca (CCS), ou olho seco, é uma doença ocular inflamatória crônica frequente em cães e humanos, que ocorre devido a deficiência de produção da porção aquosa do filme lacrimal (deficiência quantitativa) e/ou pela evaporação excessiva da lágrima (deficiência qualitativa), afetando principalmente a córnea e a conjuntiva podendo evoluir para cegueira. O tratamento consiste principalmente no uso como substitutos da lágrima e o uso de imunossupressores (ciclosporina, tacrolimus e pimecrolimus) (STEVENSON et al, 2012). Alguns estudos na Medicina e na Veterinária mostraram bons resultados no controle da CCS com a utilização de ácidos graxos essenciais (AGE), ω-3 e ω-6, devido à sua capacidade de produzir mediadores anti-inflamatórios (BARABINO et al., 2003; NEVES et al., 2013) Como o óleo de peixe e o óleo de linhaça são fontes de AGE, porém com diferenças na sua composição e concentração, e até o presente momento não há um estudo comparativo da eficácia destes compostos no tratamento da CCS. O objetivo deste estudo foi comparar a eficácia no tratamento de ceratoconjuntivite seca (CCS) induzida experimentalmente em coelhos, entre duas fontes de ômega 3 e 6 por via oral, o óleo de peixe (OP) e o óleo de linhaça (OL). Foram utilizados 28 coelhos, fêmeas, da raça Nova Zelândia, divididos em 4 grupos com 7 animais cada: Grupo C (controle), Grupo OP (óleo de peixe), Grupo OL (óleo de linhaça) e Grupo OPL (óleo de peixe e óleo de linhaça). Os animais foram avaliados pelo Teste Lacrimal de Schirmer (TLS), Teste de Rosa Bengala (TRB), Teste de Fluoresceína (TF), Tempo de Ruptura do Filme Lacrimal (TRFL), citologia ocular e análise histopatológica. Os resultados demonstraram que houve aumento significativo nos valores de TLS e TRFL em todos os grupos de tratamento, porém esse aumento foi mais precoce no grupo OP. No TRB o desempenho dos grupos foi similar. Com relação ao parâmetro TF, a marcação negativa foi mais tardia no grupo OPL. Houve uma diminuição significativa no número de células caliciformes no grupo OPL em relação aos demais grupos.Os resultados demonstraram que o OP e OL por via oral melhoram os sinais clínicos da CCS, porém essa melhora foi mais rápida com o OP. O uso combinado dos óleos não trouxe benefício adicional. Esses resultados podem contribuir no futuro com novas formulações orais úteis no tratamento adjuvante da CCS.
Chen, Hongjiang. "Studies on Cell Injury Induced by Hypoxia-Reoxygenation and Oxidized Low Density Lipoprotein : With Special Reference to the Protectiove Effect of Mixed Tocopherols, Omega-3 Fatty Acids and Transforming Growth Factor-beta1." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3769.
Повний текст джерелаSanders, Lisa Merle. "Effects of dietary fat and fiber on the oxidative status of the small intestine and colon of rats." Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/3764.
Повний текст джерелаChee, Brian. "Long chain omega-3 fatty acids as an adjunct to non-surgical periodontal therapy: a randomised double-blind placebo controlled trial." Thesis, 2015. http://hdl.handle.net/2440/92344.
Повний текст джерелаThesis (D.Clin.Dent.) -- University of Adelaide, School of Dentistry, 2015
"Omega-3 Supplementation and Body Weight in Healthy Young Women." Master's thesis, 2013. http://hdl.handle.net/2286/R.I.16438.
Повний текст джерелаDissertation/Thesis
M.S. Nutrition 2013
Metherel, Adam Henry. "Omega-3 Fatty Acid Blood Biomarkers Before and After Acute Fish Oil Supplementation in Men and Women." Thesis, 2007. http://hdl.handle.net/10012/3241.
Повний текст джерелаAndersson, Jonas. "Ökar omega-3-fettsyror graden av muskelproteinsyntes hos vuxna?" Thesis, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-104472.
Повний текст джерелаLoss of muscle mass with aging impairs physical functions, but also reduces quality of life andcan lead to weakness and premature death. Omega-3 fatty acids stimulate protein anabolism andmay therefore be usefull to treat sarcopenia. Purpose: The aim of this study was to evaluate theeffect of omega-3 fatty acid supplements on the degree of muscle protein synthesis in adults.Metod: The study is conducted as a literature study where relevant scientific and publishedstudies, evaluations and its results have been analyzed to answer the purpose of the study. Therelevance of the studies were assessed on the basis of the title and abstract of the articles. 234studies in Onesearch, 5 studies in PubMed were initially reviewed. 30 abstracts were read, 21studies were read in full text, based on the inclusion and exclusion criteria 7 studies wereselected for the study after reading in full text. Results: Most studies have evaluated the effect ofomega-3 supplements in younger adults (18-30 years) and older adults (65 years and older).Although there is a relative lack of studies evaluating the development of omega-3 supplementson MPS in adults 30-70 years, it seems that omega-3 can promote anabolic increases in olderindividuals. Couclusion: Further research is needed in this area to draw relevant conclusions.This literature review concludes that omega-3 fatty acids stimulate the synthesis of muscleprotein in adults and may be useful to prevent and treat sarcopenia.
"Fish Oil Supplementation and Cardiovascular Disease Risk in Individuals of Blood Type A and Blood Type O." Master's thesis, 2014. http://hdl.handle.net/2286/R.I.25146.
Повний текст джерелаDissertation/Thesis
M.S. Nutrition 2014
Head, Sally K. "The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma." Thesis, 2012. http://hdl.handle.net/1805/2752.
Повний текст джерелаAsthma, a chronic inflammatory disease of the airways, affects nearly 25 million Americans. The vast majority of these patients suffer from exercise-induced bronchoconstriction (EIB), a complication of asthma. Although traditionally treated pharmacologically, nutritional strategies provide a promising alternative for managing EIB as the prevalence of asthma may be due in part to changes in diet. Our objective was to determine the effects of novel nutritional strategies on hyperpnea-induced bronchoconstriction (HIB) in asthmatic individuals. HIB uses rapid breathing to identify EIB in a research or clinical setting. Fish oil, a combination of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docsahexaenoic acid (DHA), has been shown to be effective in suppressing EIB. However, its use in combination with other nutritional supplements, the optimal fish oil formula, and its effect on smooth muscle contractility have not been fully explored. An in vivo study (study 1) was conducted in individuals with both asthma and HIB to determine whether a combination of fish oil and vitamin C was more effective than either one alone in alleviating HIB. Pulmonary function was significantly improved with both fish oil and the combination treatment but not with vitamin C alone. In study 2, individuals with both asthma and HIB were supplemented with DHA alone since the optimal formula for fish oil has yet to be ascertained; previous in vitro studies have suggested DHA may be the more potent omega-3 fatty acid in fish oil. However, no significant changes in pulmonary function or airway inflammation were seen with DHA supplementation. For study 3, canine airway smooth muscle tissue was treated with fish oil to determine the in vitro effect of fish oil on smooth muscle contractility. Acute treatment with fish oil relaxed smooth muscle strips that had been contracted with 5-hydroxytryptamine. These minor relaxations in smooth muscle tension with fish oil may represent significant changes at the level of the smaller airways. These studies have confirmed that fish oil represents a viable treatment modality for asthmatic individuals with EIB and suggest that fish oil may influence airway smooth muscle contractility.
Miller, Mathew. "The assessment of omega 3 oil sources for use in aquaculture – alternatives to the unsustainable harvest of wild fish stocks." 2007. http://eprints.utas.edu.au/7788.
Повний текст джерелаHill, Alison M. "DHA-rich fish oil and regular moderate exercise: a combined intervention to improve cardiovascular, metabolic and inflammatory biomarkers in obesity." 2007. http://hdl.handle.net/2440/39341.
Повний текст джерелаhttp://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1283720
Thesis (PhD) -- School of Molecular and Biomedical Science, 2007
Hill, Alison M. "DHA-rich fish oil and regular moderate exercise: a combined intervention to improve cardiovascular, metabolic and inflammatory biomarkers in obesity." Thesis, 2007. http://hdl.handle.net/2440/39341.
Повний текст джерелаThesis (PhD) -- School of Molecular and Biomedical Science, 2007
Gawlik, Nicola Rachael. "A randomised controlled trial of DHA-rich fish oil supplementation during pregnancy and subsequent development of language in early childhood." Thesis, 2016. http://hdl.handle.net/2440/104057.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Medicine, 2016.
Phang, Melinda. "Differential effects of long chain omega-3 polyunsaturated fatty acids on platelet aggregation and hemostatic variables in healthy male versus female subjects." Thesis, 2013. http://hdl.handle.net/1959.13/938766.
Повний текст джерелаThrombosis is a critical event that accounts for considerable morbidity and mortality in the Western world. Thrombosis is associated with arterial diseases including, myocardial infarction, stroke, and peripheral occlusive disease as well as with venous thromboembolic disorders. Consequently, the primary goal for the prevention of arterial and venous thrombosis to combat disease progression is to limit thrombus extension. Platelet activation and aggregation is considered to be central to thrombus production; thus anti-thrombotic treatments to inhibit platelet activity have been a major drug target to retard the thrombotic and atherosclerotic processes. Despite extensive resource investment in cardiovascular research and treatment, the current pharmacological strategies for the inhibition of platelet aggregation, although effective, may present limitations and adverse health effects have been reported. Given the toll taken by thrombotic complications, a safe and efficacious non-pharmacological approach may be paramount for the prevention and management of thrombotic disease. While a wealth of evidence supports that fish oil provides preventative or ameliorative effects against thrombotic disease, the mechanisms responsible for this association are not understood and are further complicated by contrasting reports. Fish oils are a rich source long chain omega-3 polyunsaturated fatty acids including eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), however it is not clear whether the anti-thrombotic effects are due to EPA or DHA or whether both are equally effective. In the available literature relating fish oil and platelet aggregation, wide variability in terms of dosage, concentration ratios, study design, subject characteristics and gender inequality are apparent, hence there is discrepancy regarding the effect of fish oils on platelet activity. Consequently, the anti-thrombotic potential of fish oil supplementation is controversial and largely disregarded by the medical community. This dissertation investigated the independent effects of EPA and DHA on platelet and coagulant activity. A series of three controlled studies were undertaken to elucidate the mechanisms by which EPA and DHA influence hemostatic parameters with the hope to resolve the existing controversy. The ultimate and unifying theme of these studies was to provide a safe and efficacious approach to optimise cardio-protection via anti-thrombotic potential of EPA versus DHA. Firstly, an in vitro investigation was carried out that compared the effects of EPA with DHA on platelet aggregation in healthy male and female subjects. The inhibition of platelet aggregation by EPA/DPA/DHA was equally effective and correlated with lag time; however most strikingly the results were influenced in a gender-specific manner. These observations suggest that interactions between sex hormones and fish oils exist to influence platelet response differentially. With a new perspective of gender bias effects, an acute supplementation study monitored the platelet responses up to 24 hours after consumption of a single dose of an EPA versus DHA-rich oil capsule in thirty male and female subjects. The kinetics of the EPA and DHA supplement on platelet activity was examined according to gender stratified treatment. Subgroup gender analysis showed that the anti-aggregatory effects of EPA were predominately evident in males while female platelets were more responsive to DHA. The marked decrease in platelet aggregation with EPA supplementation was paralleled with a reduction in platelet microparticle activity in the male subjects only, and an inverse relationship between testosterone levels and platelet responses were observed. Findings from this study reflected the in vitro observations and suggest that EPA and DHA inhibit platelet aggregation via independent pathways compounded by sex hormonal influences. Confirmation of gender-specific platelet responses with omega-3 fatty acid supplementation was achieved in a chronic supplementation study involving ninety-four healthy male and female subjects. Subsequently, this four week dietary intervention trial demonstrated that the anti-thrombotic potential is apparent with longer term exposure to EPA/DHA and explored the mechanistic pathways. Significant interactions between gender and treatment were observed; the effects of EPA were specific in reducing platelet aggregation and specific coagulation factors in males, whereas no effects were observed in the female cohort. Conversely, the effects of DHA were unique to females with a similar decrease in platelet aggregability. Interactions between sex hormones with coagulation factors and retention of EPA and DHA in plasma were also observed.In conclusion, the study findings presented in this thesis provide evidence that the effects of EPA and DHA on platelet aggregation are apparent; the effects are neither shared nor complementary, rather they are gender-specific. Furthermore, the results herein may explain the existing controversy between fish oils, platelets and thrombosis that have intrigued clinical investigators for several decades. With respect to thrombotic disease risk, males would likely benefit more from supplementation with EPA while females are more responsive to DHA. The significance of these findings allows optimal cardio-protection tailored for both gender groups offering a safe and efficacious non-pharmacological approach.
Sung, Hyunsin. "The effect of krill oil supplementation focusing on the incorporation of plasma omega-3 polyunsaturated fatty acids, clinical biomarkers and lipidomic profiles in women." Thesis, 2017. https://vuir.vu.edu.au/36975/.
Повний текст джерелаHull, M. A., A. C. Sandell, A. A. Montgomery, R. F. A. Logan, G. M. Clifford, C. J. Rees, Paul M. Loadman, and D. Whitham. "A randomised controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma (or polyp) prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: The seAFOod (Systematic Evaluation of Aspirin and Fish Oil) Polyp Prevention Trial." 2013. http://hdl.handle.net/10454/9532.
Повний текст джерелаThe naturally-occurring omega (ω)-3 polyunsaturated fatty acid (PUFA) eicosapentaenoic acid (EPA) reduces colorectal adenoma (polyp) number and size in patients with familial adenomatous polyposis. The safety profile and potential cardiovascular benefits associated with ω-3 PUFAs make EPA a strong candidate for colorectal cancer (CRC) chemoprevention, alone or in combination with aspirin, which itself has recognized anti-CRC activity. Colorectal adenoma number and size are recognized as biomarkers of future CRC risk and are established as surrogate end-points in CRC chemoprevention trials. The seAFOod Polyp Prevention Trial is a randomized, double-blind, placebo-controlled, 2 × 2 factorial ‘efficacy’ study, which will determine whether EPA prevents colorectal adenomas, either alone or in combination with aspirin. Participants are 55–73 year-old patients, who have been identified as ‘high risk’ (detection of ≥5 small adenomas or ≥3 adenomas with at least one being ≥10 mm in diameter) at screening colonoscopy in the English Bowel Cancer Screening Programme (BCSP). Exclusion criteria include the need for more than one repeat endoscopy within the three-month BCSP screening period, malignant change in an adenoma, regular use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs, regular use of fish oil supplements and concomitant warfarin or anti-platelet agent therapy. Patients are randomized to either EPA-free fatty acid 1 g twice daily or identical placebo AND aspirin 300 mg once daily or identical placebo, for approximately 12 months. The primary end-point is the number of participants with one or more adenomas detected at routine one-year BCSP surveillance colonoscopy. Secondary end-points include the number of adenomas (total and ‘advanced’) per patient, the location (left versus right colon) of colorectal adenomas and the number of participants re-classified as ‘intermediate risk’ for future surveillance. Exploratory end-points include levels of bioactive lipid mediators such as ω-3 PUFAs, resolvin E1 and PGE-M in plasma, urine, erythrocytes and rectal mucosa in order to gain insights into the mechanism(s) of action of EPA and aspirin, alone and in combination, as well as to discover predictive biomarkers of chemopreventive efficacy. The recruitment target is 904 patients.
Medical Research Council (MRC) and managed by the National Institute for Health Research (NIHR) on behalf of the MRC-NIHR partnership
Alves, Beatriz Cerqueira Bento. "Relatório de Estágio e Monografia intitulada “Ácidos Gordos Ómega-3 e o seu Potencial Anti-Inflamatório: Benefícios na Saúde"." Master's thesis, 2020. http://hdl.handle.net/10316/93112.
Повний текст джерелаOs ácidos gordos polinsaturados incluem classes como os ácidos gordos ómega-3 (AG ω-3) e os ácidos gordos ómega-6 (AG ω-6) essenciais na dieta humana, cuja estrutura dita o seu papel biológico. Enquanto os AG ω-6 estão associados a comportamentos pro-inflamatórios, os ácidos gordos ómega-3 têm vindo a conquistar uma elevada importância devido aos seus efeitos pro-resolutivos e anti-inflamatórios. Os AG ω-3, tal como o ácido eicosapentaenóico (EPA) e o ácido docosahexaenóico (DHA), presentes em grandes quantidades em peixes gordos e óleos de peixe, possibilitam a produção de eicosanóides (tais como prostaglandinas e leucotrienos) biologicamente menos potentes do que os produzidos através da metabolização do ácido araquidónico (ARA), um AG ω-6, e a produção de mediadores especializados na pró-resolução, como é o caso das resolvinas e das protectinas. Igualmente, reduzem a quimiotaxia de leucócitos, a expressão da molécula de adesão, a própria interação leucócito-endotélio, a produção de citocinas inflamatórias e da reatividade das células T. A obtenção destes efeitos anti-inflamatórios ainda não se encontra totalmente esclarecida, porém, mostra-se estar relacionada com a alteração da composição dos ácidos gordos na membrana fosfolipídica (permitindo uma maior metabolização de EPA e/ou DHA ao invés doARA), com a redução da expressão de genes inflamatórios através da inibição da ativação do Fator Nuclear Kappa B (NF-B) e através da ativação do fator de transcrição anti-inflamatório, denominado recetor ativado por proliferadores de peroxissoma tipo gama (PPAR-γ), e do recetor acoplado à proteína G (GPR120). Esta diminuição de eventos inflamatórios e posterior sintomatologia pode, então, ser atenuada pelos AG ω-3, motivo pelo qual apresenta benefícios em patologias inflamatórias crónicas como a asma e a artrite reumatoide, ou até mesmo nodesenvolvimento cerebral, obesidade, diabetes e doenças cardiovasculares.
Polyunsaturated fatty acids include classes such as omega 3 fatty acids (ω-3 FA) and omega-6 fatty acids (ω-6 FA) essential in the human diet, whose structure dictates their biological role. While ω-6 FA are associated with pro-inflammatory effects, ω-3 FA have managed to gain significant importance due to their pro-resolving and anti inflammatory effects. The ω-3 FA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), present in large amounts in oily fish and fish oils, enable the production of eicosanoids (such as prostaglandins and leukotrienes), biologically less potent than those produced by the metabolism of arachidonic acid (ARA), an ω-6 FA, and the production of specialized pro-resolving mediators,such as resolvins and protectins. It also decreases leukocyte chemotaxis, adhesion molecule, the own leukocyte-endothelium interaction expression, production of inflammatory cytokines and T-cell reactivity. The achievement of these anti inflammatory effects is not yet fully understood, but it has been shown to be related to an altered fatty acid composition in membrane phospholipids (allowing metabolism of EPA and/or DHA instead of ARA), decreasing inflammatory gene expression by inhibiting transcription factor nuclear factor kappa B (NF-B) activation, and by activating the anti-inflammatory transcription factor named peroxisome gamma proliferator activated receptor (PPAR-γ) and G protein coupled receptor (GPR120). This decrease in inflammatory events and subsequent symptoms can be attenuatedby FA ω-3, which is why it has benefits in chronic inflammatory pathologies such as asthma and rheumatoid arthritis, or even in brain development, obesity, diabetes and in cardiovascular diseases.
Venkateswaran, Lakshmi 1965. "Effect of n-3 vs n-6 fatty acids and methyl ethyl ketone peroxide on adipose tissue cellularity, muscle weight, and lipoprotein lipase activity in rats." Thesis, 1993. http://hdl.handle.net/1957/26056.
Повний текст джерелаLange, Bålman Miriam. "GRAVIDA KVINNORS INTAG AV KOSTTILLSKOTT : En kvantitativ studie med fokus på järn och probiotika." Thesis, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157637.
Повний текст джерелаAbstract Background Vitamin and mineral deficiencies in pregnant women can lead to miscarriage and serious disturbances in children’s development. The intestinal flora of the mother is most likely transmitted to the child during childbirth and may lay the foundation for the child's health. One possible solution to ensure an adequate intake may be the consumption of dietary supplements and probiotics. At present, there is insufficient data on supplement consumption among pregnant women. Objective The purpose of the study was to examine how many pregnant women in Västerbotten County chose to consume dietary supplements, mainly iron and probiotics, and whether there was a difference between different factors and intake. Method A quantitative cross-sectional study where pregnant women (n=1473) from the Northpop-study in Västerbotten County responded to a questionnaire regarding consumption of dietary supplements and factors such as age, education, diet etc. The material was analyzed in SPSS with Chi-2-test, independent T-Test and Mann-Whitney U-Test. Using significance level <0.05. Results The majority of participants, 90 percent, responded that they consumed dietary supplements. The factors that increased the intake of dietary supplements in pregnant women were higher age (p=0.030), higher education (p=0.006) and vegetarian/vegan diet (p=0.021). Iron was reported to be consumed by 804 people, 55 percent. The factors that increased the intake of iron supplement in pregnant women were vegetarian/vegan diet (p=0.001). Probiotics were consumed by 25 people, 2 percent. Living in urban areas (p=0.024) and eating vegetarian/vegan diet (p=0.002) increased consumption of probiotics. Conclusion The majority of participants chose to consume some type of dietary supplement, half of the participants consumed iron supplements and a small part consumed probiotics. It appears that pregnant women who are low educated, younger, eating an omnivorous diet and living outside urban areas are in the risk zone for not consuming dietary supplements.
Northpop