Статті в журналах: "PDMv2"

1

Duan, Yang, Zhihua Xu, Hongyi Li, Xiaonan Cai, Cancan Chang, and Benqiang Yang. "Prominent deep medullary veins: a predictive biomarker for stroke risk from transient ischemic attack?" Acta Radiologica 59, no. 5 (August 16, 2017): 606–11. http://dx.doi.org/10.1177/0284185117726813.

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Background Deep medullary veins (DMVs) are a biomarker of severity and prognosis in patients with acute cerebral infarction. However, their clinical significance remains unclear in patients with transient ischemic attack (TIA). Purpose To determine whether prominent deep medullary veins (PDMVs) are a predictive biomarker for stroke risk after TIA. Material and Methods Clinical and imaging data of 49 patients with TIA and 49 sex- and age-matched controls were studied. PDMVs were defined as DMVs with a score of 3 (TDMVs) or asymmetric DMVs (ADMVs), and the relationship between PDMVs and clinical features was analyzed. The DMV score based on susceptibility weighted imaging (SWI) ranged from 0 (not visible) to 3 (very prominent) and was calculated for both hemispheres separately. A different score in each hemisphere was defined as ADMVs and an equal score was defined as symmetric DMVs. The asymmetry and score of DMVs were compared between the two groups and with respect to the time from TIA onset to imaging analysis. Results Agreement between neuroradiologists for the DMV asymmetry/score on SWI was excellent. The frequency of ADMVs and TDMVs was significantly higher in patients with TIA than controls ( P < 0.05). The patients showed no correlation between the time from TIA onset to imaging and the DMV asymmetry/score ( P > 0.05); PDMVs were not correlated with age, blood pressure, or diabetes. However, PDMVs were associated with the ABCD2 score (≥4), clinical symptoms, and duration of TIA (≥10 min). Conclusion Prominent deep medullary veins is a predictive biomarker for the risk of stroke in many patients having suffered from TIA.

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Suzuki, Takanori, Yuto Sakano, Tomohiro Iwai, Shinichi Iwashita, Youhei Miura, Ryo Katoono, Hidetoshi Kawai, Kenshu Fujiwara, Yasushi Tsuji, and Takanori Fukushima. "Electrochromic and unique chiroptical properties of helically deformed tetraarylquinodimethanes generated from less-hindered dicationic precursors upon reduction." Pure and Applied Chemistry 86, no. 4 (April 17, 2014): 507–16. http://dx.doi.org/10.1515/pac-2013-1003.

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AbstractElectron-donating 1,1,4,4-tetraarylbutadiene is a representative electrochromic dye, and the same chromophore can be found in 9,10-bis(diarylmethylene)-9,10-dihydrophenanthrene (dibenzo-oQD) albeit in a fixed s-cis geometry. Unlike thermodynamically unstable 7,7,8,8-tetraaryl-o-quinodimethane, spontaneous electrocyclization is prohibited by dibenzo-annulation. Several derivatives of dibenzo-oQD were successfully generated despite highly strained geometry caused by steric hindrance between the bulky diarylmethylene units. Their precursors are phenanthrene-9,10-diyl bis(diarylmethylium) dyes (PDM2+) stabilized by four electron-donating alkoxy groups. The redox pairs of dibenzo-oQD/PDM2+ exhibit vivid change in color upon redox interconversion (electrochromism). Both dibenzo-oQD and PDM2+ adopt a helical conformation, whose configuration is unstable. When a chiral alkoxy substituent is attached on each of the aryl groups, the point chirality is successfully transmitted to helicity of PDM2+. Resulting diastereomeric biasing is the key for dibenzo-oQD/PDM2+ to exhibit the two-way-output response (e.g., UV–vis and CD). In addition, much more strained quinodimethane derivatives, 1,2-bis(diarylmethylene)acenaphthene and 1,16-diaryldibenzo[b,n]perylene, were also generated from the dicationic precursors, demonstrating that the reductive transformation can serve as a useful protocol to generate severely deformed π-conjugated systems.

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3

Barker, Jamie B., Andrew L. Evans, Pete Coffee, Matt J. Slater, and Paul J. McCarthy. "Consulting on Tour: A Dual-Phase Personal-Disclosure Mutual-Sharing Intervention and Group Functioning in Elite Youth Cricket." Sport Psychologist 28, no. 2 (June 2014): 186–97. http://dx.doi.org/10.1123/tsp.2013-0042.

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In a one group pretest-posttest design, 15 elite academy cricketers were exposed to two personal-disclosure mutual-sharing (PDMS) sessions during a preseason tour. Within PDMS1, athletes disclosed (via prepared speeches) relationship-oriented information and within PDMS2, mastery oriented information. Social identity, social identity content, and collective efficacy were measured at baseline (1 week before the tour), post-PDMS1, midpoint, and post-PDMS2, while social validation was also obtained after each intervention session. Quantitative data revealed significant increases in social identity and friendships identity content at post-PDMS1, and results identity content and collective efficacy at post-PDMS2. Qualitative social validation data highlighted the thoughts and feelings of the athletes before their speeches and supported the effectiveness of the PDMS sessions. In sum, the data suggest practitioners can develop team outcomes (e.g., a focus on results) through developing specific aspects of teams’ identities. Study limitations, practitioner guidelines, and areas for future research are discussed.

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4

Elzey, Bennett D., Scott A. Crist, Daniel L. Sprague, and Timothy L. Ratliff. "Response: Are PDMVs the biologically active source of CD154 in ATR?" Blood 112, no. 12 (December 1, 2008): 4780–81. http://dx.doi.org/10.1182/blood-2008-07-165357.

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5

Mushtaq, Shehla, Nasir M. Ahmad, Azhar Mahmood, and Mudassir Iqbal. "Antibacterial Amphiphilic Copolymers of Dimethylamino Ethyl Methacrylate and Methyl Methacrylate to Control Biofilm Adhesion for Antifouling Applications." Polymers 13, no. 2 (January 9, 2021): 216. http://dx.doi.org/10.3390/polym13020216.

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Amphiphilic copolymers are recognized as important biomaterials and used as antibacterial agents due to their effective inhibition of bacterial growth. In current study, the amphiphilic copolymers of P(DMAEMA-co-MMA) were synthesized using free radical polymerization by varying the concentrations of hydrophilic monomer 2-dimethylamino ethylmethacrylate (DMAEMA) and hydrophobic monomer methyl methacrylate (MMA) having PDI value of 1.65–1.93. The DMAEMA monomer, through ternary amine with antibacterial property optimized copolymers, P(DMAEMA-co-MMA), compositions to control biofilm adhesion. Antibacterial activity of synthesized copolymers was elucidated against Gram-positive Staphylococcus aureus (ATCC 6538) and Gram-negative Escherchia coli (ATCC 8739) by disk diffusion method, and zones of inhibition were measured. The desired composition that was PDM1 copolymer had shown good zones of inhibition i.e., 19 ± 0.33 mm and 20 ± 0.33 mm for E. coli and S. aureus respectively. The PDM1 and PDM2 have exhibited significant control over bacterial biofilm adhesion as tested by six well plate method. SEM study of bacterial biofilm formation has illustrated that these copolymers act in a similar fashion like cationic biocide. These compositions viz. PDM1 and PDM2, may be useful in development of bioreactors, sensors, surgical equipment and drug delivery devices.

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Mushtaq, Shehla, Nasir M. Ahmad, Azhar Mahmood, and Mudassir Iqbal. "Antibacterial Amphiphilic Copolymers of Dimethylamino Ethyl Methacrylate and Methyl Methacrylate to Control Biofilm Adhesion for Antifouling Applications." Polymers 13, no. 2 (January 9, 2021): 216. http://dx.doi.org/10.3390/polym13020216.

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Amphiphilic copolymers are recognized as important biomaterials and used as antibacterial agents due to their effective inhibition of bacterial growth. In current study, the amphiphilic copolymers of P(DMAEMA-co-MMA) were synthesized using free radical polymerization by varying the concentrations of hydrophilic monomer 2-dimethylamino ethylmethacrylate (DMAEMA) and hydrophobic monomer methyl methacrylate (MMA) having PDI value of 1.65–1.93. The DMAEMA monomer, through ternary amine with antibacterial property optimized copolymers, P(DMAEMA-co-MMA), compositions to control biofilm adhesion. Antibacterial activity of synthesized copolymers was elucidated against Gram-positive Staphylococcus aureus (ATCC 6538) and Gram-negative Escherchia coli (ATCC 8739) by disk diffusion method, and zones of inhibition were measured. The desired composition that was PDM1 copolymer had shown good zones of inhibition i.e., 19 ± 0.33 mm and 20 ± 0.33 mm for E. coli and S. aureus respectively. The PDM1 and PDM2 have exhibited significant control over bacterial biofilm adhesion as tested by six well plate method. SEM study of bacterial biofilm formation has illustrated that these copolymers act in a similar fashion like cationic biocide. These compositions viz. PDM1 and PDM2, may be useful in development of bioreactors, sensors, surgical equipment and drug delivery devices.

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7

Chang, Ning, Qingqing Sun, Yiqiong Li, Yajuan Mu, Jinglei Hu, Yue Feng, Xiaomin Liu, and Hongbo Gao. "PDV2 has a dosage effect on chloroplast division in Arabidopsis." Plant Cell Reports 36, no. 3 (December 17, 2016): 471–80. http://dx.doi.org/10.1007/s00299-016-2096-6.

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8

Commendatore, Víctor. "Función β celular en prediabetes tipo 2. Eficacia terapéutica en prediabetes: opciones de preservación de célula beta". Revista de la Sociedad Argentina de Diabetes 55, № 3Sup (25 листопада 2021): 19. http://dx.doi.org/10.47196/diab.v55i3sup.500.

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La evolución del islote de Langerhans, y dentro de éste del pool celular β desde la normalidad hasta la diabetes mellitus tipo 2 (DM2), pasa por diferentes momentos dentro de los que pueden observarse la hiperplasia adaptativa inicial a la insulinorresistencia y su posterior claudicación con una reducción de la masa celular mayor al 50%, aumento de las células α, fibrosis y aparición de depósitos amiloides1. Entre estos dos períodos, se detecta uno intermedio, correspondiente al que clínicamente se manifiesta como prediabetes (PDM2), en el que ya existen alteraciones en la dinámica de secreción normal de la insulina, con pérdida de su primer pico2.Para prevenir la progresión desde la PDM2 a la DM2, se plantean diferentes estrategias terapéuticas:• Monitorizar anualmente a estas personas ante el posible desarrollo de DM2 (E*).• Incorporarlas a programas de cambios en el estilo de vida (CEV) para lograr y mantener una pérdida del peso corporal de al menos el 7% (A).• Incorporarlas a rutinas de actividad física de al menos 150 minutos semanales de caminata enérgica (A).• Con planes de alimentación adecuados (B).• Utilizando programas de asistencia a través de aplicaciones (B).Dado su costo-efectividad (A), todos estos programas deberían ser costeados por el sistema de salud3.Se encontró que, aún sin pérdida de peso, 150 minutos semanales de actividad física (700 kcal/semana) redujeron la incidencia de DM2 en un 44%; también que, si bien un 7% de la pérdida de peso corporal es suficiente para disminuir la incidencia de DM2, los resultados son mejores reduciendo un 10%. Se estimó necesaria una pérdida de peso de entre 0,5 y 1 Kg/semana, con una restricción calórica de entre 500 y 1000 calorías/día, no habiendo un patrón definido respecto de la composición de la dieta para lograr este objetivo4.Dado que los CEV son difíciles de lograr o mantener, se puede considerar el uso de fármacos. Aquellos que demostraron efectividad en estudios aleatorizados prospectivos son: acarbosa, liraglutida, rosiglitazona, pioglitazona, glargina, orlistat, fentermina más topiramato y metformina.La metformina es la recomendada por la American Diabetes Association3 y ésta más acarbosa por la American Association of Clinical Endocrinologist and American College of Endocrinology sumando, de existir PDM2 con más de un criterio diagnóstico, TZD y/o a-GLP1. Debe tenerse en cuenta que, sumado a los CEV, con el objeto de disminuir el peso, se puede agregar medicación u otras terapias como la cirugía bariátrica5.* Nivel de evidencia

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9

Sun, Bing, Qi-yang Zhang, Huan Yuan, Wei Gao, Bo Han, and Min Zhang. "PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring." Plant Physiology 182, no. 4 (January 31, 2020): 1966–78. http://dx.doi.org/10.1104/pp.19.01490.

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10

Takatsu, H., H. Yoshizawa, and Y. Maeno. "Comparative study of conductive delafossites with and without frustrated spins on a triangular lattice, PdMO2(M= Cr;Co)." Journal of Physics: Conference Series 145 (January 1, 2009): 012046. http://dx.doi.org/10.1088/1742-6596/145/1/012046.

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11

Shen, Yanfei, Shuiju Wang, and Kaihuei Huang. "Effects of chloride precursors on the palladium valency and surface structures of PdMg2+/SiO2catalysts for carbon monoxide hydrogenation." Applied Catalysis 57, no. 1 (January 1990): 55–70. http://dx.doi.org/10.1016/s0166-9834(00)80723-x.

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12

Miyagishima, Shin-ya, John E. Froehlich, and Katherine W. Osteryoung. "PDV1 and PDV2 Mediate Recruitment of the Dynamin-Related Protein ARC5 to the Plastid Division Site." Plant Cell 18, no. 10 (September 22, 2006): 2517–30. http://dx.doi.org/10.1105/tpc.106.045484.

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13

Parnovsky, S. L. "Possible Modification of the Standard Cosmological Model to Resolve a Tension with Hubble Constant Values." Ukrainian Journal of Physics 66, no. 9 (October 4, 2021): 739. http://dx.doi.org/10.15407/ujpe66.9.739.

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The tensions concerning the values of Hubble constant obtained from the early and the late Universe data pose a significant challenge to modern cosmology. Possible modifications of the flat homogeneous isotropic cosmological ΛCDM model are considered, in which the Universe contains the dark energy, cold baryonic matter, and dark matter. They are based on general relativity and satisfy two requirements: (1) the value of the Hubble constant calculated from the value of the Hubble parameter at the recombination by formulas of the flat ΛCDM model, should be equal to 92% of the one based on low-redshift observations; (2) deviations from the ΛCDM model should not lead to effects that contradict astronomical observations and estimations obtained thereof. The analysis showed that there are few opportunities for the choice. Either we should consider DM with negative pressure −pdmc2 ≪ pdm < 0, which weakly affects the evolution of the Universe and the observed manifestations of DM, or we should admit the mechanism of generation of new matter, for example, by the dark energy decay.

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14

Paudel, Sarita, Je Won Park, Joo Ho Lee, Yeo Joon Yoon, and Jae Kyung Sohng. "Functional analysis of ABC transporter genes pdmR1 and pdmR2 in Actinomadura hibisca P-1752 and enhancement of pradimicin production." Biotechnology and Bioprocess Engineering 17, no. 1 (February 2012): 8–15. http://dx.doi.org/10.1007/s12257-011-0310-5.

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15

Bailón-Salas, Ana M., Luis A. Ordaz-Diaz, and Pedro A. Domínguez-Calleros. "Agave durangensis vinasse as a biocide for forest pest control." BioResources 17, no. 1 (January 5, 2022): 1285–300. http://dx.doi.org/10.15376/biores.17.1.1285-1300.

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In forestry practice, the prevention and fight against insect pests and diseases is a priority to preserve the health of these ecosystems. To combat it, insecticides of chemical and biological origin have been used. However, there are alternatives that have not yet been investigated, e.g., the use of agro-industrial waste. In the mezcal distillation process, polluting liquid residues called vinasses are generated, and these can be considered for pest control. In this project, the effect of vinasse from Agave durangensis subjected to different treatments was studied to evaluate its effect on forest phytopathogenic fungi. The mezcal vinasse was characterized physicochemically and by its metabolites. Furthermore, the percentage of inhibition in vitro of phytopathogenic (causing root wilt) fungi isolated from Pinus cooperi seedlings was studied. The fungi inhibition was related to the vinasse concentration. The lower pH and sterile raw vinasse showed a better inhibition effect. Four phytopathogenic strains of Pinus cooperi were isolated and identified, which corresponded to the genera Fusarium, Aspergillus, and Penicillium. None of the isolated were able to grow in potato dextrose-mezcal vinasse medium (PDMVM). Therefore, the mezcal vinasse showed fungicide activity in vitro against all strains.

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Rao, A. V., K. Bala, and J. C. Tarafdar. "Dehydrogenase and phosphatase activities in soil as influenced by the growth of arid-land crops." Journal of Agricultural Science 115, no. 2 (October 1990): 221–25. http://dx.doi.org/10.1017/s0021859600075158.

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SUMMARYThe distribution of dehydrogenase activity (DHA) and the activities of phosphatases were studied in the rhizosphere of four varieties each of clusterbean (Cyamopsis tetragonoloba (L.) Taub.), mung bean (Vigna radiata (L.) Wilczek), moth bean (Vigna aconitifolia (Jacq.) Marechal) and pearl millet (Pennisetum americanum (L.) Leeke) grown in pots containing soil low in available P. Activities of dehydrogenase and phosphatases were greatest 25 days after sowing and remained constant from 50 days after sowing until crop maturity. Rhizosphere soils showed higher activities than other soils: 26–158% for acid phosphatase, 66–264% for alkaline phosphatase and up to 292% for DHA. Dehydrogenase and alkaline phosphatase activities were significantly higher in the rhizospheres of legumes than in those of P. americanum.In general, the rhizospheres of C. tetragonoloba ‘HFG314’, V. radiata ‘PDM62’, V. aconitifolia ‘IPCMO344’ and P. americanum ‘RCB2’ had higher activities than those of other varieties of the same species. Acid phosphatase activity was lower than alkaline phosphatase activity and differences between species and varieties were small and nonsignificant. The results suggest that the higher phosphatase activities in the rhizospheres of some crops may increase P availability and utilization from arid soils.

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17

Bersoult, Anne, Sylvie Camut, Ariana Perhald, Attila Kereszt, György B. Kiss, and Julie V. Cullimore. "Expression of the Medicago truncatula DMI2 Gene Suggests Roles of the Symbiotic Nodulation Receptor Kinase in Nodules and During Early Nodule Development." Molecular Plant-Microbe Interactions® 18, no. 8 (August 2005): 869–76. http://dx.doi.org/10.1094/mpmi-18-0869.

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The Medicago truncatula DMI2 gene encodes a receptorlike kinase required for establishing root endosymbioses. The DMI2 gene was shown to be expressed much more highly in roots and nodules than in leaves and stems. In roots, its expression was not altered by nitrogen starvation or treatment with lipochitooligosaccharidic Nod factors. Moreover, the DMI2 mRNA abundance in roots of the nfp, dmi1, dmi3, nsp1, nsp2, and hcl symbiotic mutants was similar to the wild type, whereas lower levels in some dmi2 mutants could be explained by regulation by the nonsense-mediated decay, RNA surveillance mechanism. Using pDMI2::GUS fusions, the expression of DMI2 in roots appeared to be localized primarily in the cortical and epidermal cells of the younger, lateral roots and was not observed in the root apices. Following inoculation with Sinorhizobium meliloti, the DMI2 gene was induced in the nodule primordia, before penetration by the infection threads. No increased expression was seen in lateral-root primordia. In nodules, expression was observed primarily in a few cell layers of the preinfection zone. These results are consistent with the DMI2 gene mediating Nod factor perception and transduction leading to rhizobial infection, not only in root epidermal cells but also during nodule development.

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18

Javed, Awais, Pierre Mattar, Suying Lu, Kamil Kruczek, Magdalena Kloc, Anai Gonzalez-Cordero, Rod Bremner, Robin R. Ali, and Michel Cayouette. "Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina." Development 147, no. 18 (September 2, 2020): dev188730. http://dx.doi.org/10.1242/dev.188730.

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ABSTRACTMultipotent retinal progenitor cells (RPCs) generate various cell types in a precise chronological order, but how exactly cone photoreceptor production is restricted to early stages remains unclear. Here, we show that the POU-homeodomain factors Pou2f1/Pou2f2, the homologs of Drosophila temporal identity factors nub/pdm2, regulate the timely production of cones in mice. Forcing sustained expression of Pou2f1 or Pou2f2 in RPCs expands the period of cone production, whereas misexpression in late-stage RPCs triggers ectopic cone production at the expense of late-born fates. Mechanistically, we report that Pou2f1 induces Pou2f2 expression, which binds to a POU motif in the promoter of the rod-inducing factor Nrl to repress its expression. Conversely, conditional inactivation of Pou2f2 in RPCs increases Nrl expression and reduces cone production. Finally, we provide evidence that Pou2f1 is part of a cross-regulatory cascade with the other temporal identity factors Ikzf1 and Casz1. These results uncover Pou2f1/2 as regulators of the temporal window for cone genesis and, given their widespread expression in the nervous system, raise the possibility of a general role in temporal patterning.This article has an associated ‘The people behind the papers’ interview.

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Hsieh, Chia-Hsuan, Nur Adila Mohd Razali, Wei-Chih Lin, Zhi-Wei Yu, Dwita Istiqomah, Yohei Kotsuchibashi, and Hsing-Hao Su. "Development of Thermo-Responsive Polycaprolactone–Polydimethylsiloxane Shrinkable Nanofibre Mesh." Nanomaterials 10, no. 7 (July 21, 2020): 1427. http://dx.doi.org/10.3390/nano10071427.

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A thermally activated shape memory polymer based on the mixture of polycaprolactone (PCL) and polydimethylsiloxane (PDMS) was fabricated into the nanofibre mesh using the electrospinning process. The added percentages of the PDMS segment in the PCL-based polymer influenced the mechanical properties. Polycaprolactone serves as a switching segment to adjust the melting temperature of the shape memory electro-spun PCL–PDMS scaffolds to our body temperature at around 37 °C. Three electro-spun PCL–PDMS copolymer nanofibre samples, including PCL6–PDMS4, PCL7–PDMS3 and PCL8–PDMS2, were characterised to study the thermal and mechanical properties along with the shape memory responses. The results from the experiment showed that the PCL switching segment ratio determines the crystallinity of the copolymer nanofibres, where a higher PCL ratio results in a higher degree of crystallinity. In contrast, the results showed that the mechanical properties of the copolymer samples decreased with the PCL composition ratio. After five thermomechanical cycles, the fabricated copolymer nanofibres exhibited excellent shape memory properties with 98% shape fixity and above 100% recovery ratio. Moreover, biological experiments were applied to evaluate the biocompatibility of the fabricated PCL–PDMS nanofibre mesh. Owing to the thermally activated shape memory performance, the electro-spun PCL–PDMS fibrous mesh has a high potential for biomedical applications such as medical shrinkable tubing and wire.

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20

Alexopoulou, Konstantina I., Catherine P. Raptopoulou, Vassilis Psycharis, Aris Terzis, Vassilis Tangoulis, Theocharis C. Stamatatos, and Spyros P. Perlepes. "Solvent-Dependent Access to Two Different Ni4II Core Topologies from the First Use of Pyridine-2,6-dimethanol in Nickel(II) Cluster Chemistry." Australian Journal of Chemistry 65, no. 12 (2012): 1608. http://dx.doi.org/10.1071/ch12424.

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The use of pyridine-2,6-dimethanol, pdmH2, in reactions with nickel(ii) acetate has led to two Ni4 clusters, depending on the solvent. [Ni4(O2CMe)4(pdmH)4]·MeCN (1·MeCN) can be obtained from MeCN and [Ni4(O2CMe)6(pdmH)2(EtOH)2]·1.2EtOH (2·1.2EtOH) from EtOH. Each cluster can be converted into the other in the appropriate solvent. The tetranuclear cluster molecule 1 possesses a distorted cubane {Ni4(μ3-OR)4}4+ core (RO– = pdmH–) with the NiII atoms and the alkoxide-type oxygen atoms from the η3 : η1 : μ3 pdmH– ligands occupying alternate vertices of the cube; four η1 : η1 : μ MeCO2– groups cap four faces of the cube. The four NiII atoms in molecule 2 are located at four vertices of a defective dicubane and are bridged by six oxygen atoms, two μ3 from the η3 : η1 : η1 : μ3 pdmH– ligands and four from four monoatomically bridging MeCO2– groups; peripheral ligation is provided by two η1 : η1 : μ MeCO2– groups and two terminal EtOH ligands. IR data are discussed in terms of the coordination modes of the ligands. Variable-temperature direct-current magnetic susceptibility data of 1 and 2 were modelled with two and three J values respectively, indicating diamagnetic ground states (S = 0). The sign and the magnitude of the J values are discussed in terms of structural features of the complexes.

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Glynn, Jonathan M., John E. Froehlich, and Katherine W. Osteryoung. "Arabidopsis ARC6 Coordinates the Division Machineries of the Inner and Outer Chloroplast Membranes through Interaction with PDV2 in the Intermembrane Space." Plant Cell 20, no. 9 (September 2008): 2460–70. http://dx.doi.org/10.1105/tpc.108.061440.

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Byers, Peter K., Allan J. Canty, Brian W. Skelton, and Allan H. White. "The oxidative addition of lodomethane to [PdMe2(bpy)] and the X-ray structure of the organopalladium(IV) product fac-[PdMe3(bpy)l](bpy = 2,2′-bipyridyl)." J. Chem. Soc., Chem. Commun., no. 23 (1986): 1722–24. http://dx.doi.org/10.1039/c39860001722.

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Desjardins, Sylvie Y., Alison A. Way, Michael C. Murray, Dan Adirim, and Michael C. Baird. "Nature of the Initiation, Propagation, and Chain Transfer Steps during the Formation of Ethylene Oligomers Catalyzed by PdMe2(N,N,N‘N‘-tetramethylethylenediamine)/B(C6F5)3." Organometallics 17, no. 12 (June 1998): 2382–84. http://dx.doi.org/10.1021/om971060p.

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Johnscher, Michael, Marcel Kersting, Samir F. Matar, and Rainer Pöttgen. "CaTMg2 and CaTCd2 (T =Rh, Pd, Pt) with YPd2Si-type Structure." Zeitschrift für Naturforschung B 68, no. 2 (February 1, 2013): 111–20. http://dx.doi.org/10.5560/znb.2013-2317.

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The intermetallic calcium compounds CaTMg2 and CaTCd2 (T =Rh, Pd, Pt) were obtained by high-frequency melting of the elements in sealed niobium ampoules or through reactions in muffle furnaces. The polycrystalline samples were characterized by powder X-ray diffraction. They crystallize with a site occupancy variant of YPd2Si, a ternary ordered version of Fe3C. The structures of CaPdMg2 and CaPdCd2 were refined from single-crystal diffractometer data: Pnma, a=792.2(2), b=803.4(2), c=572.0(1) pm, wR2=0.0663, 1621 F2 values, 24 variables for Ca0:94PdMg2:06 and a=794.6(2), b=809.5(3), c=554.7(2) pm, wR2=0.0301, 819 F2 values, 23 variables for CaPdCd2. A small range of homogeneity was observed for Ca1-xPdMg2+x. The magnesium and cadmium atoms build up three-dimensional tetrahedral substructures (306 - 327 pm Mg-Mg and 307 - 317 pm Cd-Cd) that resemble hexagonal diamond, lonsdaleite. Together with the palladium atoms one obtains three-dimensional, covalently bonded [PdMg2] and [PdCd2] networks which leave cages for the calcium atoms. The latter are bonded to these networks via shorter Ca-Pd contacts (298 - 319 pm in Ca0:94PdMg2:06 and 295 - 312 pm in CaPdCd2). The course of the interatomic distances is in line with calculated overlap populations. The CaPdMg2, SrPdMg2 and CaRhIn2 structures are all derived from a CaIn2-related subcell by an ordered filling of transition metal atoms into trigonal prisms. This leads to different herringbone patterns for the networks of puckered and elongated hexagons of magnesium and indium atoms.

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25

Bhat, K. M., and P. Schedl. "The Drosophila miti-mere gene, a member of the POU family, is required for the specification of the RP2/sibling lineage during neurogenesis." Development 120, no. 6 (June 1, 1994): 1483–501. http://dx.doi.org/10.1242/dev.120.6.1483.

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The Drosophila POU gene miti-mere (previously known as pdm2) has a complex spatial and temporal pattern of expression during early development; initially it is expressed in gap-gene-like pattern, then in 14 stripes and finally in a subset of the cells in the developing CNS and PNS. To study the function of this gene during development, we generated a ‘synthetic anti-morphic mutation’ by expressing a truncated version of the miti protein from a constitutive hsp83 and an inducible hsp70 promoter. We show that these delta miti transgenes behave like classical antimorphic mutations. Using these dominant negative transgenes, together with deletions and a duplication for the gene, we show that miti is required during segmentation and neurogenesis. We have also used temperature-shift experiments with the hsp70 delta miti transgene to demonstrate that miti function in segmentation is distinct and separable from its function during neurogenesis. In segmentation, miti appears to be required in the specification of the segments A2 and A6. In the CNS, miti is required for the elaboration of the NB4-2-->GMC-1-->RP2/sib lineage. miti is initially required in this lineage to establish the identity of the parental ganglion mother cell, GMC-1. miti must then be down-regulated to allow the asymmetric division of GMC-1 into the RP2 and its sibling cell.

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Chew, Ching Hoong, Yvonne Ai Lian Lim, and Kek Heng Chua. "Heterologous expression of Plasmodium vivax apical membrane antigen 1 (PvAMA1) for binding peptide selection." PeerJ 5 (September 13, 2017): e3794. http://dx.doi.org/10.7717/peerj.3794.

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Background Plasmodium is an obligate intracellular parasite. Apical membrane antigen 1 (AMA1) is the most prominent and well characterized malarial surface antigen that is essential for parasite-host cell invasion, i.e., for sporozoite to invade and replicate within hepatocytes in the liver stage and merozoite to penetrate and replicate within erythrocytes in the blood stage. AMA1 has long served as a potent antimalarial drug target and is a pivotal vaccine candidate. A good understanding of the structure and molecular function of this Plasmodium protein, particularly its involvement in host-cell adhesion and invasion, is of great interest and hence it offers an attractive target for the development of novel therapeutics. The present study aims to heterologous express recombinant Plasmodium AMA1 ectodomain of P. vivax (rPvAMA1) for the selection of binding peptides. Methods The rPvAMA1 protein was heterologous expressed using a tag-free Profinity eXactTM system and codon optimized BL21-Codon Plus (DE3)-RIL Escherichia coli strain and further refolded by dialysis for renaturation. Binding peptides toward refolded rPvAMA1 were panned using a Ph.D.-12 random phage display library. Results The rPvAMA1 was successfully expressed and refolded with three phage-displayed dodecapeptides designated as PdV1 (DLTFTVNPLSKA), PdV2 (WHWSWWNPNQLT), and PdV3 (TSVSYINNRHNL) with affinity towards rPvAMA1 identified. All of them exhibited positive binding signal to rPvAMA1 in both direct phage assays, i.e., phage ELISA binding assay and Western blot binding assay. Discussion Phage display technology enables the mapping of protein-protein interactions based on a simple principle that a library of phage particles displaying peptides is used and the phage clones that bind to the target protein are selected and identified. The binding sites of each selected peptides toward PvAMA1 (Protein Data Bank, PDB ID: 1W8K) were in silico predicted using CABS-dock web server. In this case, the binding peptides provide a valuable starting point for the development of peptidomimetic as antimalarial antagonists directed at PvAMA1.

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Canty, Allan J., and Hong Jin. "SnBrMe3 and dichalcogenides (ER)2 as oxidants: Synthesis of platinum(IV) complexes, and C⋯C and C⋯E coupling from pallada(IV)cyclopentane complexes and PdMe2(EPh){(pz)3BH} {E=O2C, S, Se; [(pz)3BH]−=tris(pyrazol-1-yl)borate}." Journal of Organometallic Chemistry 565, no. 1-2 (August 1998): 135–40. http://dx.doi.org/10.1016/s0022-328x(98)00454-9.

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28

Tan, Avalene W. K., Ronald H. L. Li, Yu Ueda, Joshua A. Stern, Mehrab Hussain, Satoshi Haginoya, Ashely N. Sharpe, Catherine T. Gunther-Harrington, Steven E. Epstein, and Nghi Nguyen. "Platelet Priming and Activation in Naturally Occurring Thermal Burn Injuries and Wildfire Smoke Exposure Is Associated With Intracardiac Thrombosis and Spontaneous Echocardiographic Contrast in Feline Survivors." Frontiers in Veterinary Science 9 (July 14, 2022). http://dx.doi.org/10.3389/fvets.2022.892377.

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Wildfires pose a major health risk for humans, wildlife, and domestic animals. We previously discovered pathophysiologic parallels between domestic cats with naturally occurring smoke inhalation and thermal burn injuries and human beings with similar injuries; these were characterized by transient myocardial thickening, cardiac troponin I elevation and formation of intracardiac thrombosis. While the underlying mechanisms remain unclear, results from murine models suggest that platelet priming and activation may contribute to a global hypercoagulable state and thrombosis. Herein, we evaluated and compared the degree of platelet activation, platelet response to physiologic agonists and levels of platelet-derived microvesicles (PDMV) in 29 cats with naturally occurring wildfire thermal injuries (WF), 21 clinically healthy cats with subclinical hypertrophic cardiomyopathy (HCM) and 11 healthy cats without HCM (CC). We also quantified and compared circulating PDMVs in WF cats to CC cats. In addition, we examined the association between thrombotic events, severity of burn injuries, myocardial changes, and the degree of platelet activation in cats exposed to wildfires. Flow cytometric detection of platelet surface P-selectin expression showed that WF cats had increased platelet response to adenosine diphosphate (ADP) and thrombin compared to the two control groups indicating the presence of primed platelets in circulation. In addition, cats in the WF group had increased circulating levels of PDMV, characterized by increased phosphatidylserine on the external leaflet. Cats in the WF group with documented intracardiac thrombosis had elevated platelet activation and platelet priming in the presence of ADP. While high dose arachidonic acid (AA) mostly resulted in platelet inhibition, persistent response to AA was noted among cats in the WF group with intracardiac thrombosis. Univariate and multiple logistic regression analyses demonstrated that increased platelet response to AA was independently associated with thrombotic events. This is the first study reporting the significant association between platelet priming and intracardiac thrombosis in domestic cats with naturally occurring wildfire-related injuries and smoke inhalation. Further studies are required to delineate additional mechanisms between inflammation and thrombosis, especially regarding platelet primers and the cyclooxygenase pathway.One Sentence SummaryPlatelet activation and shedding of platelet-derived microvesicles due to platelet priming is present following naturally occurring wildfire smoke exposure and thermal burn injuries in a population of domestic cats.

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Ezcurra Loiola, Patxi. "Cuándo y cómo iniciar la insulinización." La insulina: un antes y un después en el tratamiento de la diabetes, October 13, 2021, 14–20. http://dx.doi.org/10.52102/insulina/art-2.

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La insulinización en las personas con diabetes mellitus tipo 2 (PDM2) debe realizarse en el momento del diagnóstico cuando existe clínica de insulinopenia y cifras elevadas de glucemia basal (> 300 mg/dl) o hemoglobina glucosilada (HbA1c )> 10 %. También cuando no se logran los objetivos individualizados del paciente tras triple terapia con antidiabéticos no insulínicos (ADNI), valorando previamente las comorbilidades de la PDM2 y sus preferencias. El comienzo se realizará preferentemente con insulina basal 10 UI o 0,2 UI/kg de peso en obesos administrada antes de acostarse. El ajuste de la dosis se realiza en función de las glucemias basales, priorizando el autoajuste de la dosificación por parte de la PDM2. Deben mantenerse los tratamientos con ADNI al comenzar con insulina basal y se aconseja retirar la sulfonilurea y las meglitinidas con la introducción de la insulina prandial. Debieran contemplarse estrategias para las distintas barreras al inicio de la insulinización por parte de las PDM2.

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Wang, Wenhe, Jinyu Li, Qingqing Sun, Xiaoyu Yu, Weiwei Zhang, Ning Jia, Chuanjing An, et al. "Structural insights into the coordination of plastid division by the ARC6–PDV2 complex." Nature Plants 3, no. 3 (March 2017). http://dx.doi.org/10.1038/nplants.2017.11.

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Wang, Lulu, Mingdong Tang, Wenwen Huang, Jinjie An, Xiaomin Liu, and Hongbo Gao. "A Tissue-Chopping Based Immunofluorescence Staining Method for Chloroplast Proteins." Frontiers in Plant Science 13 (May 19, 2022). http://dx.doi.org/10.3389/fpls.2022.910569.

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Immunofluorescence staining is an important method for detecting the localization of proteins in the cell. It is also frequently used in the localization study of chloroplast-division proteins. Although this method has been improved before by using protoplasts, it still has some limitations. Now we developed a new method to make it much easier. We just broke the plant leaf tissue with a serrated blade, stained the samples directly, and simply lysed the tissue into separatable cells. The localization of the target protein can then be observed with a clear view. Since this method directly uses broken leaf pieces, it is very fast. It can also be applied to the plants in which protoplasts are difficult to prepare. We first used this method to observe the localization of a chloroplast division protein FtsZ1 in the wild-type Arabidopsis. A ring was clearly seen in the middle of chloroplasts. In addition, we used this method to analyze the localization of FtsZ1 in arc3 and pdv2 mutants, as well as in dozens of other species, including some woody plants. This new immunofluorescence staining method is not only easy to use, but also has a wide applicability in various plants.

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Zhang, Zhipeng, Jinyao Wang, Guoming Xing, Meilan Li, and Sen Li. "Integrating physiology, genetics, and transcriptome to decipher a new thermo-sensitive and light-sensitive virescent leaf gene mutant in cucumber." Frontiers in Plant Science 13 (August 16, 2022). http://dx.doi.org/10.3389/fpls.2022.972620.

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Chloroplasts are the material basis of photosynthesis, and temperature and light severely affect chloroplast development and thus influence photosynthetic efficiency. This study identified a spontaneous virescent leaf mutant, SC311Y, whose cotyledons and true leaves were yellow and gradually turned green. However, temperature and light affected the process of turning green. In addition, this mutant (except at the seedling stage) had ruffled leaves with white stripes, sterile males, and poorly fertile female flowers. Genetic characteristics analysis revealed that the recessive gene controlled the virescent leaf. Two F2 populations mapped v-3 to the interval of 33.54–35.66 Mb on chromosome 3. In this interval, BSA-Seq, RNA-Seq, and cDNA sequence analyses revealed only one nonsynonymous mutation in the Csa3G042730 gene, which encoded the RNA exosome supercomplex subunit resurrection1 (RST1). Csa3G042730 was predicted to be the candidate gene controlling the virescent leaf, and the candidate gene may regulate chloroplast development by regulating plastid division2 (PDV2). A transcriptome analysis showed that different factors caused the reduced chlorophyll and carotenoid content in the mutants. To our knowledge, this study is the first report of map-based cloning related to virescent leaf, male-sterile, and chloroplast RNA regulation in cucumber. The results could accelerate the study of the RNA exosome supercomplex for the dynamic regulation of chloroplast RNA.

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"1D Effective Stress Site Response Analysis; Using Stress Based Pore Pressure Model and Plasticity Model." Journal of Applied and Emerging Sciences, June 25, 2020, 6–12. http://dx.doi.org/10.36785/buitems.jaes.304.

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The accumulated stress based porewater pressure (PWP) generation model is a simplified model using the concept of damage parameter. The only input of this PWP model is liquefaction resistance curve (CRR-N). The model is very useful since the CSR-N curves can be developed empirically from in-situ penetration tests measurements. In this research work the estimation of excess PWP development during seismic loading by using stress based PWP generation model is compared with a rigorous plasticity model. One dimensional (1D) effective stress nonlinear site response analyses were conducted in DEEPSOIL and Opensees using the stress based PWP model and PressureDependentMultiYield02 (PDMY2) model, respectively. The site response analysis were performed on a sand column 30 m in depth comprises of a low density liquefiable layer in between two dense non-liquefiable layers. Three bed rock outcropping motions with peak ground acceleration (PGA) level of 0.11 g, 0.124 g and 0.357 g were used as input motion in the analysis. The maximum ru profiles computed from the two models were compared and analyzed. The ru time histories at the center of the non-liquefiable layers and liquefiable layer were also compared. The comparisons revealed that the two models used in this study compute most comparable ru values. The computed ru is also found in line with density of soil and the PGA of the input ground motions where the ru increases with increase in the PGA and decreases with increasing density.

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Wu, Zhengzhong, Leye Yan, Junqing Lin, Kun Ke, and Weizhu Yang. "Constitutive TDO2 expression promotes liver cancer progression by an autocrine IL-6 signaling pathway." Cancer Cell International 21, no. 1 (October 17, 2021). http://dx.doi.org/10.1186/s12935-021-02228-9.

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Abstract Background Increased tryptophan (Trp) metabolism by indoleamine 2,3-dioxygenase (IDO)/tryptophan 2,3-dioxygenase (TDO) represents one of the most studied pathways for immunosuppression in tumor tissues. However, the pro-tumor effects induced by Trp metabolism remain controversial. Methods The paraffin sections of tumor tissues were obtained from patients with liver cancer and examined by immunohistochemical staining to investigate the role of Trp metabolic enzymes. To further confirm the pro-tumor effects induced by TDO2, we established TDO2 overexpression SMC-7721 and HepG2 liver cancer cell lines, and western blotting, cell proliferation, and colony formation were evaluated. Meanwhile, liver cancer subcutaneous mice models were established, and the tumorigenic rates of SMC-7721 cells, tumor volume and survival of bearing mice were calculated. In addition, the survival data of liver cancer patients from The Cancer Genome Atlas (TCGA) database were downloaded to analyze the effect of TDO2 expression on the survival of patients with liver cancer. Results Here, we showed that constitutive TDO2 expression gave rise to liver cancer through upregulation of Trp metabolism. And the TDO2 expression was positively correlated with the poor prognosis in liver cancer patients. TDO2 expression in tumor cells accounted for the release of kynurenine (Kyn), which activated aryl hydrocarbon receptor (AhR) to promote liver cancer cells proliferation. Mechanistically, we found that AhR expression contributed to the secretion of Interleukin-6 (IL-6), thereby promoting tumor cells proliferation through the STAT3 and NF-kB/TIM4 signals. Interrupt of AhR signals by PDM2 revealed improved outcomes in subcutaneous tumor-bearing mice. Conclusions Together, our study showed that the TDO2/Kyn/AhR/IL-6 signaling pathway was a novel mechanism underlying the malignancy of liver cancer, and suggested that AhR signals might be a valuable therapeutic target for tumor therapy.

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