Дисертації з теми "PBAC"
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Pereira, Danilo Assis. "Adaptação e evidências de validade do teste neuropsicológico PBAC para a população brasileira." reponame:Repositório Institucional da UnB, 2014. http://repositorio.unb.br/handle/10482/17166.
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Instrumentos de rastreio cognitivos são utilizados em todo o mundo por vários profissionais de saúde para detectar indivíduos com provável comprometimento cognitivo. O teste PBAC(Philadelphia Brief Assessment of Cognition) foi proposto a partir de uma série de instrumentos neuropsicológicos bem estabelecidos na literatura para avaliar comportamento social, memória,linguagem, percepção visoespacial e funções executivas. A literatura aponta que os subtestes do PBAC são correlacionados com perda de massa encefálica em pacientes com doenças neurodegenerativas. Este estudo tem como objetivo verificar evidências de validade da adaptação brasileira do teste de rastreio cognitivo PBAC usando amostras clínicas e populacionais, comparando-o a outros testes de rastreio cognitivo e funcionais. Participaram deste estudo 325 voluntários entre 18 e 94 anos de idade (mediana de 65), com escolaridade entre 0 e 19 anos (mediana de 13). Quatro amostras distintas foram utilizadas: 103 jovens universitários, 183 idosos hígidos, 24 pacientes portadores de demências (sendo mais comum a doença de Alzheimer) e 16 Kalungas moradores da região de Cavalcante-GO, descendentes dos quilombolas. Outros instrumentos de rastreio cognitivo (MEEM, Teste do Relógio, Trilhas A e B,Stroop) e funcionais (GDS e Pfeffer) foram utilizados numa sub amostra para a validação convergente e discriminante. Análises especiais de modelagem de equação estrutural Bayesiana(BSEM) e teoria de resposta ao item multidimensionais (TRIm) e multigrupo foram utilizadas. O teste PBAC possui boa confiabilidade na amostra geral (alfa = 0,86), mas não na amostra de jovens (0,37). Quatro dimensões distintas foram encontradas: memória, linguagem, habilidade visoconstrutiva e funções executivas. O modelo BSEM mostrou para o grupo de idosos hígidos que a idade influencia negativamente a memória, mas não as demais habilidades. A escolaridade apresentou influência positiva em todos os constructos latentes. Com exceção dos itens Escrita e Trilhas, todos os demais apresentaram maior informação nas habilidades latentes dos idosos com demência, quando comparados aos hígidos nas funções de informações da TRI multigrupo.Tabelas normativas com a habilidade (teta), escore z e escala T foram calculadas para cada dimensão do teste, tendo como norma os dados dos idosos hígidos. O teste de rastreio cognitivo PBAC se mostrou tão sensível e específico quanto o MEEM para a detecção de demência do tipo Alzheimer. O teste é mais informativo em pessoas com habilidades latentes mais baixas. A retirada de alguns itens do teste pode aumentar sua acurácia para o diagnóstico de Alzheimer,no entanto mais estudos com outros grupos clínicos se tornam essenciais, uma vez que sua construção objetivou a avaliação multiclínica. ________________________________________________________________________________ ABSTRACT
Cognitive screening tests are used worldwide by many health professionals to detect individuals with probable cognitive impairment. The PBAC (Philadelphia Brief Assessment of Cognition) was proposed based on a series of well-established neuropsychological instruments to assess socialbehavior/comportment, memory, language, visuospatial perception, and executive functions. The literature indicates that the subtests of the PBAC are correlated with loss of brain tissue in patients with several neurodegenerative diseases. This study aims to find evidence of validation of the PBAC using clinical and population samples, and comparing it to other cognitive and functional screening tests. Participated in this study 325 individuals aged between 18 and 94 years-old(median 65), and schooling between 0 and 19 years (median 13). Four different samples were used: 103 university students, 183 healthy elderly, 24 patients with dementia (most common being Alzheimer's disease), and 16 afro-descendants (called Kalungas, living at Cavalcante-GO). All participants signed a consent form. Other cognitive screening instruments (MMSE, Clock Design Test, Trail Tests A and B, and Victoria Stroop Test) and functional tests (Pfeffer and GDS) were used in a subsample for the convergent and discriminant validity. Special analysis of Bayesianstructural equation modeling (BSEM), multi-group and multidimensional response theory item(mIRT) were used. The PBAC test showed good reliability in the overall sample (alpha = 0.86),but not in the youth sample (0.37). Four distinct dimensions were found: memory, language,executive functions, and visuos patial perception. The BSEM model showed that in healthy elderly people, age negatively influences memory, but not other skills. Education had a positive influence on all latent constructs. Except Writing and Oral Trails, all other items presented greaterinformation on the latent abilities for the clinical group when compared to the information functions of the healthy elderly group. Normative tables with the ability (theta), z scale, and T scores were calculated for each dimension of the test, using the healthy elderly normative data. The PBAC cognitive screening test proved to be as sensitive and specific as the MMSE for detecting cognitive disorders associated to Alzheimer’s dementia. The test is more informative on those individuals with lower latent abilities. The withdrawal of some items can increase PBAC’saccuracy for the diagnosis of Alzheimer's, however further studies with other clinical groups are essential since its construction aimed to evaluate other kind of neurodegenerative disease.
CALO', LUCIA. "ANALISI DEI PROBLEMI GINECOLOGICI ED OSTETRICI NELLE DONNE CON COAGULOPATIA A DIATESI EMORRAGICA ATTRAVERSO IL REGISTRO INTERNAZIONALE (WRBDD)." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/170490.
Повний текст джерелаSilva, Rafael Soares. "Termo-estabilização da blenda PLA/PBAT." Universidade Presbiteriana Mackenzie, 2016. http://tede.mackenzie.br/jspui/handle/tede/2854.
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This study aimed to evaluate the effects of additives (primary and secondary antioxidants) in thermal stabilization process of poly (lactic acid) / poly (butylene adipate-co-terephthalate) - PLA / PBAT using a torque rheometer as a preliminary tool evaluation of the stabilization process. The additives Irganox 1010, Irganox 1076, Irganox B900, Irgafos 168, and a flavonoid were used in two concentrations, 0.3 and 0.5% w/w. The assessment of the effects of stabilizing additives was carried out by monitoring the torque during mixing molar mass measurements, infrared analysis, turbidity and Scanning Electron Microscopy of the samples after processing. It carried out the monitoring of the pure blend torque values and addition of stabilizing additives during processing up to 5 minutes in an internal mixer of the type "mixer" under rotation of 60 rpm and a temperature of 180 °C. Within a series of primary and secondary antioxidants, it was found that some of these additives failed torque values greater than or similar to the pure blend at certain concentrations (Irganox 1076, Irganox B900 and Irgafos 168). molar mass measurements showed that pure processed blend undergoes a large number of chain scission and most additives stabilizing action achieved unless the flavonoid. One important information obtained through analyzes of torque rheometry and molar mass that is higher drying time strongly prevents hydrolysis reactions. Comparing the infrared spectra of pure and pure blend blend processed, there is not the appearance of no new peak occurs due to the degradative process. By UV-Vis analysis of the polymer solutions we verified the presence of crosslinked polymer microstructures due to thermo-oxidative reactions. Images obtained by scanning Elletrônica Microscopy (SEM), one can observe the presence of two distinct phases for the pure blend processed, and the use of additives in both compositions show a much smaller difference of phases to blend pure. These results indicate the possibility of using commercial additives used for non-biodegradable polymers in systems using biodegradable polymers.
Este trabalho teve como objetivo avaliar a ação de aditivos (antioxidantes primários e secundários) no processo de estabilização térmica da blenda poli(ácido láctico)/poli(butileno adipato-co-tereftalato) - PLA/PBAT usando um reômetro de torque como ferramenta prévia de avaliação do processo de estabilização. Os aditivos Irganox 1010, Irganox 1076, Irganox B900, Irgafos 168 e o Flavonóide foram usados em duas concentrações, 0,3 e 0,5% em massa. A avaliação dos efeitos dos aditivos estabilizantes foi realizada por meio de monitoramento do torque durante mistura, medidas de massa molar, análises de infravermelho, turbidez e microscopia eletrônica de varredura das amostras após processamento. Realizou-se o monitoramento dos valores de torque da blenda pura e com adição de aditivos estabilizantes durante processamento por até 5 minutos em um misturador interno do tipo “Mixer” sob rotação de 60 rpm e temperatura de 180 oC. Dentro de uma série de antioxidantes primários e secundários, verificou-se o uso de alguns desses aditivos conseguiram valores de torque superior ou semelhante ao da blenda pura em determinadas concentrações (Irganox 1076, Irganox B900 e Irgafos 168). Medidas de massa molar mostraram que a blenda pura processada sofre um grande número de cisão de cadeias e que a maioria dos aditivos conseguiram ação estabilizante menos o flavonóide. Uma informação importante obtida por meio das análises de reometria de torque e massa molar é que um tempo maior de secagem evita fortemente as reações de hidrólise. Comparando-se os espectros de infravermelho da blenda pura e da blenda pura processada, nota-se que não aparecem nenhum novos picos relacionados ao processo degradativo. Através da análise de UV-Vis das soluções poliméricas verificou-se a presença de microestruturas poliméricas reticuladas em virtude das reações termo-oxidativas. Imagens obtidas por Microscopia Elletrônica de varredura (MEV), evidenciam a presença de duas fases distintas para a blenda pura processada, e o uso dos aditivos nas duas composições mostram uma diferenciação das fases muito menor que para blenda pura. Esses resultados indicam que existe a possibilidade do uso de aditivos comerciais usados para polímeros não-biodegradáveis em sistemas com polímeros biodegradáveis.
Fu, Yang. "Morphologie des mélanges ternaires PLA/PBAT/PA." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEM068/document.
Повний текст джерелаThis work aims at achieving direct core-shell morphologies in ternary PLA/PBAT/PA polymer blends by melt mixing. The final goal is to improve the toughness of polylactic acid (PLA). The morphology of multi-phase polymer blends is controlled by the thermodynamics of the system. The morphology of ternary blends can be predicted from the relative values of the three spreading coefficients characterizing the triplet of polymers. Spreading coefficients are calculated from the values of interfacial tensions between binary components. The determination of interfacial tensions between a PLA, a poly(butylene adipate-co-terephthalate) (PBAT) and a copolyamide (PA) predicts a complex dispersed morphology in the PLA matrix where PA subinclusions are partly encapsulated in the PBAT phase. This morphology was obtained by melt mixing the three components, as observed by scanning electron microscopy. In a second step, selective compatibilization was used to modify the PA sub-inclusion location. To this end, PBAT-b-PLA and PA-b-PBAT di-block copolymers were synthesized. The presence of the di-block copolymers enabled to modify the interfacial tension in PLA/PBAT and PA/PBAT. The modification of the interfacial tension balance was shown to successfully change the morphology from semi-encapsulation to full encapsulation of PA sub-inclusions in the PBAT drops. The mechanical performance of this ternary blend was evaluated
Vaccioli, Kleber. "Estudo da blenda PBAT/PLA com cargas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/3/3133/tde-12072016-101827/.
Повний текст джерелаIn this work, composites were prepared with 100% biodegradable commercial blend Ecovio® C2224 BASF, a polymer blend composed of 55 wt% of a biodegradable copolyester, the Ecoflex®, poly [(butylene adipate) -co- (butylene terephthalate)], and 45 wt% of PLA poly(lactic acid). Two types of commercial clays of the smectite group, predominantly montmorillonites, were used as fillers: Cloisite Na+® and Cloisite 30B®. The commercial colloidal silica Aerosil 200®, with a surface area of 200 m2/g and an average particle diameter of 12 nm, was also used as filler. The composites containing 5 and 10 wt% of filler were obtained in a twin screw extruder coupled to a torque rheometer. This study was divided in three steps: 1st) Preparation and characterization of Ecovio®/clay and Ecovio®/silica composites; 2nd) Evaluation of the photodegradation of pure Ecovio® and of the composites; 3rd) Biodegradability assessment of pure Ecovio® and composites after exposure to UV chamber. The mechanical properties of the composites before and after the exposition to UV were evaluated by tensile and Izod impact strength. The results obtained in the 1st step showed an increase in the tensile modulus of all blends, especially for the compositions with 5 and 10 wt% of colloidal silica, which presented an increase of 115% in their tensile modulus values without significant reduction in impact and tensile strength and elongation, when compared to the pure blend. In the 2nd step, from 20 UV exposure days, all compositions (blends and composites), presented a significant reduction in the mechanical properties as a function of the increase of the UV radiation exposure time. In step 3, regardless of the filler type or content, all blend compositions showed biodegradability index, after 120 days, of 40 to 60%, due to the prior UV exposure.
Khan, Anastassiya. "Synthesis and characterization of defective PBAs electrode material." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21015/.
Повний текст джерелаBøe, Andreas Gagnat. "Degradation and Stability of PBCA and POCA Nanoparticles." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for fysikk, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22417.
Повний текст джерелаSOUSA, Jokderlea Correa de. "Estudo da cinética de cristalização do compósito poli(butileno-adipato-co-tereftalato)/fibra de coco." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/17526.
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Neste trabalho estudou-se compósitos poliméricos obtidos a partir de um poliéster biodegradável e fibra de coco (Cocus nucifera), uma fibra abundante na região Nordeste e para a qual não existem relatos na literatura de sua utilização em compósitos com o poli(butileno-adipato-co-tereftalato)(PBAT). O uso de fibra de coco nas formulações é uma alternativa para redução de custos, pois propõe uma substituição parcial do polímero a ser utilizado. Estudou-se a influência da fibra sobre as propriedades reológicas e térmicas dos compósitos. As fibras naturais foram secas e classificadas antes de sua utilização. Foi realizado um teste preliminar por Calorimetria Diferencial Exploratória (DSC) com o PBAT onde foi definida a temperatura de fusão para o processamento no reômetro. Compósitos de PBAT e fibra de coco foram preparados com formulações de 10, 20, 30, 40 e 50% em massa de fibra em um misturador interno. Foi possível quantificar a dependência do torque com a velocidade de rotação dos rotores pelo índice de pseudoplasticidade através da lei da potência. A avaliação reológica dos compósitos obtidos mostrou a dependência do torque e da temperatura com a quantidade de fibra adicionada. Foi realizado um estudo sobre a cristalização dos compósitos com 10, 20 e 30% de fibra comparando com o polímero puro, submetido as mesmas condições de preparação. A análise dos resultados obtidos pelo DSC indicou que a adição de fibras nos compósitos alterou a temperatura de cristalização para valores mais elevados, sugerindo que as fibras podem ter um efeito nucleante. Os compósitos quando submetidos a variações nas velocidades de resfriamento, mostraram que o processo de cristalização se altera, deslocando os picos de cristalização para temperaturas menores, conforme aumentava a velocidade de arrefecimento. Foi construído o modelo cinético de Pseudo-Avrami para o compósito PBAT/10% fibra de coco, pois seus parâmetros de cristalização apresentaram desvios menores ou próximos de 10% em relação ao PBAT puro. Houve boa adequação dos modelos aos dados experimentais nas três taxas de resfriamento utilizadas.
In this work, it was studied polymer composites made from a biodegradable polyester and natural coconut fibre (Cocus nucifera). Great abundance of this fibre can be found in the northeast areas of Brazil, and there are no reports in the literature of its use in polymer composites with poly (butylene-adipate-co-terephthalate). The use of coconut fiber in the formulations is an alternative for reducing costs, because it proposes a partial replacement for the polymer to be used. The study assessed the effects of the fibre on rheological and thermal properties of the biocomposites. Natural fibres were dried and classified before its utilization. Initially, the PBAT characterization was performed by differential scanning calorimetry in which were defined the melting temperature for processing in the rheometer. Composites of PBAT and coconut fibre were prepered with formulations containing 10, 20, 30, 40 and 50% in mass of fibre in the internal mixer. It was possible to quantify the dependence of torque with rotor speeds by the pseudoplasticity index through the power law. The rheological evaluation of the obtained composites showed the dependency on torque and temperature with the amount of fiber added. A study was conducted on composites crystallization of 10, 20 and 30% of fibre comparing it to the pure polymer submitted to the same conditions of preparation. Analysis of the results obtained by DSC indicated that the addition of fibres in the composite altered the crystallization temperature to higher values, suggesting that the fibres may have a nucleating effect. The composites when exposed to variations in the cooling rates, showed that the crystallization process is changed, displacing the crystallization peaks to lower temperatures as the cooling rate was increased. It was built the kinetic model of Pseudo-Avrami for the composite PBAT/10% coconut fibre, because its crystallization parameters showed lower error values or near 10% compared to pure PBAT. There was a good adjustment between models and experimental data in the three cooling rates utilized.
Abass, Abdul-Kariem. "Electrical and optical studies of lead phthalocynanine (PbPc) thin films." Thesis, Lancaster University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239800.
Повний текст джерелаReis, Pedro Rodrigo de Sousa. "Obtenção e caracterização de compósitos de blendas poliméricas biodegradáveis reforçadas com bio-hidroxiapatita." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-01112018-151923/.
Повний текст джерелаThis work presents the preparation and characterization of composites based on blends of poly (lactic acid) - PLA and poly (adipate co-terephthalate of butylene) - PBAT reinforced with bio-hydroxyapatite \"HAp\", obtained from avian eggshells waste of white color. The HAp was obtained by the wet chemical method from the acid-base reaction. Firstly, the bio-calcium carbonate (bio-CaCO3) was obtained from the avian eggshells waste. The bio-CaCO3 was submitted to a heating cycle at 800 °C in order to convert bio-CaCO3 in the bio-calcium oxide, which was then sintered at 900 °C and the bio-HAp was obtained. PLA/PBAT reinforced with 1, 3 and 5 % in weight of HAp, particle size ≤ 10 μm, were prepared by the extrusion process using a twin-screw extruder. After the extrusion process, the PLA/PBAT blend and its composites were fed into a laboratory injection molding machine and the specimens test were obtained for the characterization tests. Part of the specimens was submitted to sterilization by gamma radiation (radio-sterilization) with electron-beam using an industrial electron accelerator of 1.5 MeV, at the radiation dose of 25 kGy, room temperature and in the presence of air. HAp was characterized by X ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG) and scanning electron microscopy with field emission source (FE-SEM) analysis. The blends and composites (non-irradiated and irradiated samples) were characterized by XRD; TG; FE-SEM and differential scanning calorimetry (DSC) analysis. The thermal distortion temperature (HDT), Vicat softening temperature, tensile, flexural, and impact Izod tests were also carried out. The validation of materials sterilization process (Bioburden tests) and cytotoxicity test \"in vitro\" to evaluating the biocompatibility of the material composites were also made. XRD analyzes results showed a characteristic peak in the amorphous phase of HAp. FTIR analysis identified broad peaks and bands belonging to the molecular groups of HAp. The thermal stability of the HAp was confirmed by the TG analysis, which showed a small loss of mass with the increase of temperature due to the burning of solvents, water evaporation and burning of organic materials present in the sample of HAp. The FE-SEM images showed irregular structures characteristic of HAp. Regarding the PLA/PBAT/HAP composites, it can be observed increases up to 10 % in thermal distortion temperature and Vicat softening temperature, higher than 15 % in the tensile and flexural strength, and higher than 10 % in the Izod impact when compared with neat PLA/PBAT blend. The bioburden tests showed that radiation dose of 25 kGy was effective for sterilization of the materials. The results of the cytotoxicity test \"in vitro\" showed that all samples are biocompatible in the cellular environment, and therefore, presents a potential for \"in vivo\" study.
Schmidmaier, Ralf. "Beeinflussung der Regulatorfunktion mononukleärer Zellen des peripheren Blutes (PBMC) in vitro." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964406845.
Повний текст джерелаCabello, Hernández Pablo Jesús. "Single nanoparticle devices: Trapping and characterizaton." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/150605.
Повний текст джерелаLa fabricación y posicionamiento de nanopartículas de tamaño y composición ajustable resulta interesante debido a las propiedades que surgen producto del confinamiento en bajas dimensiones. Para acceder a ellas es necesario reemplazar los dispositivos electrónicos macroscópicos típicos por equivalentes nanométricos. En este campo, uno de los mayores retos es elaborar un esquema de medición que permita estudiar el transporte de cargas a través de una nanopartícula individual. Con tal de contactar las nanopartículas a los electrodos en este nuevo esquema, es necesario conocer tanto las propiedades de ambos como sus interacciones. Dado el tamaño reducido de las nanopartículas, resulta fundamental el poder fabricar electrodos nano-espaciados. En esta tesis se realizaron caracterizaciones eléctricas de dos tipos de nanopartículas: análogas al azul Prusiano (PBA por su sigla en ingles) y a base de hierro. Dichas nanopartículas fueron depositadas sobre muestras de electrodos nano-espaciados fabricados mediante la técnica de enmascaramiento con óxido de cromo. Se concluyó que estos dispositivos son una plataforma confiable para un amplio rango de temperaturas ($4$-$300$ K). Más aún, se pudo establecer que son compatibles tanto con técnicas actualmente disponibles como drop-casting, como con nuevas técnicas como la deposición directa de clústeres generados por pulverización catódica con magnetrón. La caracterización eléctrica de las nanopartículas de \ce{CoFe} PBA depositadas por \textit{drop-casting}, permitió demostrar que es posible atraparlas y estudiar sus curvas corriente-voltaje usando los dispositivos fabricados. Sin embargo, los datos obtenidos a bajas temperaturas no permitieron esclarecer el mecanismo involucrado en el transporte eléctrico. En este sentido es importante mencionar que se observaron dos comportamientos: Un primer grupo de dispositivos que no mostró evidencia de ser afectado por el láser ($640$ nm) y que presentó un \textit{Coulomb gap}, sugiriendo transporte individual de electrones; y un segundo grupo en el que si se evidenció un efecto tras la irradiación, que no se presenta \textit{Coulomb gap}, y cuya dependencia en temperatura de la resistencia se desvió fuertemente de la ecuación de Arrhenius ($\log(R) \propto T^{-1}$). En el caso de las nanopartículas a base de hierro, se consideró un nuevo esquema de fabricación y depósito de éstas, utilizando pulverización catódica. Mediciones a temperatura ambiente indicaron que las nanopartículas habían sido atrapadas entre los electrodos tras depositarlas. Las mediciones a baja temperatura mostraron una disminución en la resistencia medida y la aparición de un \textit{Coulomb gap}, lo que sugiere transporte individual de electrones. Usando teoría ortodoxa, y la aproximación de condensador de placas paralelas, fue posible estimar que el tamaño del punto de contacto entre la nanopartícula y los electrodos estaba en el rango de $1$ a $2$ nm, lo cual tiene sentido dado el tamaño de las primeras.
Este trabajo ha sido financiado a través de los Proyectos Fondecyt 1140770 y DAFNEOX
Megliorini, Leonardo de Souza. "Produção de filmes de PBAT/PLA por eletrofiação para liberação de nitrofurazona." Universidade Estadual do Oeste do Paraná, 2018. http://tede.unioeste.br/handle/tede/4082.
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Nitrofurazone is a drug used to treat burns and skin transplants. The drug product is salled in cream and solution form. The ecovio® polymer is composed of poly(lactic acid) / poly(butylene adipate co-teraphtalate) and is biocompatible. In this work a film with the combination of ecovio® and nitrofurazone was produced by the electrospinning technique forming nanofibers. Two films were produced. The first was produced with dimethylformamide / tetrahydrofuran (15:85 v / v) and was capable of releasing 100% of the nitrofurazone reproducibly in the dissolution profile test evaluated for 300 minutes. The second film was produced with dimethylformamide/chloroform (15:85 v/v) and released about 90% of the nitrofurazone. But did not show reproducible results in the same range. Physicalchemical analyzes lead to the conclusion that the interaction of nitrofurazone with the polymer occurs mainly among the more polar groups. The dissolution test was performed following pharmacopoeial parameters. The quantitation of the released nitrofurazone was performed by UV-Vis spectrophotometry at 375 nm. The method used was validated and proved to be adequate, showing linearity in range 0.25 - 12.50 mg.L-1 with correlation coefficient 0.9999, high precision with relative standard deviation ≤ 1.6%, accuracy 98.9 - 100.4%, selectivity and limit of quantification 0.4 mg.L-1.
A nitrofurazona é um fármaco utilizado no tratamento de queimaduras e em transplantes de pele. O medicamento é comercializado na forma de pomada e solução. O polímero ecovio® é composto de poli(ácido lático)/poli(butileno adipato coteraftalato) e é biocompatível. Neste trabalho foi produzido um filme com a combinação de ecovio® e nitrofurazona pela técnica de eletrofiação formando nanofibras. Dois filmes foram produzidos. O primeiro foi produzido com dimetilformamida/tetrahidrofurano (15:85 v/v) e foi capaz de liberar 100% da nitrofurazona de forma reprodutível no teste de perfil de dissolução avaliado por 300 minutos. O segundo filme foi produzido com dimetilformamida/clorofórmio (15:85 v/v) e liberou cerca de 90% da nitrofurazona, mas não apresentou resultados reprodutíveis no mesmo intervalo. Análises físico-químicas levam à conclusão de que a interação da nitrofurazona com o polímero ocorre principalmente entre os grupamentos mais polares. O teste de dissolução foi realizado seguindo parâmetros farmacopeicos. A quantificação da nitrofurazona liberada foi realizada por espectrofotometria na região do UV-Vis em 375 nm. O método utilizado foi validado e comprovou-se estatisticamente que é adequado, apresentando linearidade no intervalo de 0,25 a 12,50 mg.L-1 com coeficiente de correlação de 0,9999, precisão elevada com desvio padrão relativo ≤ 1,6%, exatidão de 98,9 a 100,4%, seletividade e limite de quantificação de 0,4 mg.L-1.
Silva, Misael Leonardo. "Interação do adenovírus humano, sorotipo 41, com células origem hematopoiética: análise da permissividade celular e da expressão gênica viral." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-03062008-190643/.
Повний текст джерелаIn order to verify the permissiveness of hematopoietic cells to HAdV-41 infection, PBMC and IEL from volunteers were infected. The infection assays were compared with infected HEK -293 cells. We analysed the E1A, E1B (55K), E3 (14K), VARNA, hexon and short fiber (SF) viral gene expression and GAPDH cellular gene expression. The mRNA were detected by real time PCR and the viral protein synthesis were detected by IIF. In HEK-293 cells E1A, E1B and E3 gene expression were detected 11h p.i Hexon gene expression was detected at 13h p.i, while VARNA and SF were detected 14h p.i In PBMC, E1A, E1B and VARNA gene expression were detected 17h p.i and the hexon and SF were detected 18h p.i and 20h p.i, respectively. The viral gene expression level in infected HEK-293 cells was 200 fold higher than infected PBMC. The IEL also were permissive to HAdV-41 infection showed by viral gene expressions. This is the first evidence that HAdV-41 is able to infect these cells types. These results helps to understand the virus-cell interaction mechanisms.
Boucher, Jérôme. "Feasibility studies of the pbar p -->pi0e+e- electromagnetic channel at PANDA." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00662455.
Повний текст джерелаZehetmeyer, Gislene. "Desenvolvimento e caracterização de embalagens ativas compostas de PBAT com incorporação de nisina." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/143867.
Повний текст джерелаIn this study biodegradable films were developed composed by poly(butylene adipate-co-terephthalate) (PBAT) using an antimicrobial additive (nisin) at different concentrations through three different methodologies. In the first method, films were prepared from the melt processing technique using a twin-screw extruder. The second method was based on electrospinning technique. Finally, the third methodology consists of the preparation of active bilayer films composed by extruded and electrospun matrices. The film morphology was evaluated, as well as the structural, mechanical, thermal and antimicrobial properties. Furthermore, the biodegradability of the extruded films was investigated. The micrographs for films processed by extrusion and electrospinning showed that nisin was well dispersed in the polymer matrix, presenting some agglomerates when the nisin concentration was increased. The glass transition temperature (Tg) and melting temperature (Tm) were not affected by nisin incorporation. Besides, the addition of nisin did not change the tensile strength of the films. However, the presence of nisin in higher concentration caused a decrease in elongation at break. The Young’s modulus changed with presence of nisin, suggesting a slight reduction in stiffness of these materials. The active films demonstrated inhibition against Gram-positive bacteria Listeria monocytogenes. Antimicrobial activity of the films was investigated in food simulant solutions, all samples were more active in the surfactant solutions containing Tween 20 or acetic acid, increasing until 48 h. The presence of nisin increased oxygen barrier properties to PBAT/nisin films. The biodegradation was detected after 30 days, when the films showed changes on visual aspect, then confirming the fungi action. The bilayer films showed high mechanical properties due to the synergism of the films. Therefore, PBAT/nisin films showed promising results, indicating that these new materials may be possible used as active packaging materials in food industry aiming enhanced food safety and extending the shelf life of the packaged product.
Mançanares, Ana Carolina Furlanetto. "O estudo das células Tγδ na manutenção da tolerância materna em vacas gestantes." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-13052016-110412/.
Повний текст джерелаThe maternal immune system plays an important role on the establishment and maintenance of pregnancy until the onset of parturition in mammals. Our hypothesis is that there is a recruitment of γδT-cell to the endometrium during pregnancy. These cells express a particular cytokine profile that is important to the establishment and maintenance of maternal toleranceto fetal antigens in cattle. Experiment I - To study the population dynamics of immune cells in the peripheral blood of NLNP, 1st and 3rd trimester of pregnancy, PBMCs were separated by Ficoll density gradient and the abundance of CD3+, CD4+, CD8+, CD14+, CD25+ and WC1+ was analyzed by single-color flow cytometry. There was no statistical difference of the abundance of CD3+, CD4+, CD8+ and CD25+ among groups of cows. Experiment II To analyze the gene expression profile of 1st trimester, LNP and NLNP. PBMCs were isolated by Ficoll density gradient and γδT-cells (WC1+) were enriched by magnetic cell sorting. Both PBMC and WC1+ cells gene expression was analyzed for IFNG; IL10; IL15; IL17; IL18; IL1B; IL4; IL-6; ISG15; PFR; TGFB2 and TNFA by qRT-PCR. Gene expression analysis showed increased expression of the IL1B, IL6 and TGFB2 in PBMC in NLNP compared with 1st trimester of pregnancy and LNP cows, while other genes analyzed showed no significant difference. Experiment III fragments of endometrium were collected from cows at the early (33 to 35 days of pregnancy), mid (143 to 182 days of pregnancy) and late pregnancy (228 to 247 days of pregnancy). Endometrial immune cells were quantified (CD3+, CD4+, CD8+, CD14+, CD18+, CD25+, CD62L+, and WC1+) by single-color immunofluorescence. There was an increase CD25+ and CD62L+ cells in the endometrium in early pregnancy. In the mid of pregnancy, there was an increase of WC1+ and CD14+ cells. At the end of pregnancy, there was an increase of CD14+, CD25+, CD18+ and CD62L+. In conclusion, our data suggest that the maternal immune system is modulated according to the stage of pregnancy in the cow. In early pregnancy, there is an increased number of endometrial CD25+ cells that may reflect the activation of local immune response and recruitment of putative T-reg cells to the endometrium for an active establishment of maternal tolerance to fetal antigens. While, in mid pregnancy there is a massive recruitment of γδT-cells and CD14+ to the pregnant endometrium perhaps to maintain an tolerogenic microenvironment and to promote tissue remodeling for proper fetal development and growth. Finally, in late pregnancy, there is a recruitment of effector immune cells such as CD62L+, CD18 and CD14+ cells associated with an increased expression of proinflammatory cytokines (i.e. IFNG, IL-6) to play a role on induction of parturition and uterine involution in the cow
Felix, Daniel André. "PBC and MEIS class genes in the planarian Schmidtea mediterranea." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.575479.
Повний текст джерелаKronsbein, Juliane. "Einfluss einer RSV-Exposition auf das Zytokinmuster humaner T-Lymphozyten und PBMC in vitro." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=975113704.
Повний текст джерелаKuchnier, Caroline Nogueira 1983. "Estudo do efeito de aditivo extensor de cadeia multifuncional em blendas de PLA/PBAT." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/266107.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Química
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Resumo: O poli(ácido lático), PLA, é um polímero biodegradável muito promissor para aplicações industriais e médicas. Contudo, algumas de suas características, como fragilidade à temperatura ambiente limitam sua potencial utilização e restringem sua degradação às condições de compostagem. Para promover modificações de propriedades do PLA este trabalho tem como objetivo o estudo de blendas com Poli(adipato-co-tereftalato de butileno), PBAT, outro polímero biodegradável. Buscou-se ainda, melhorar a compatibilidade entre os dois polímeros com a utilização do agente extensor de cadeia multifuncional Joncryl ADR-4368, que contém grupos epóxido reativos. Dois tipos de processamento foram adotados: em homogeneizador Drais e em reômetro de torque. Amostras dos polímeros puros e blendas em diferentes composições foram preparadas com e sem adição do extensor de cadeia. Na análise de calorimetria diferencial de varredura (DSC), a temperatura de transição vítrea (Tg) dos polímeros originais mostraram-se inalteradas nas blendas e revelou a imiscibilidade entre PLA e PBAT. O comportamento associado à fração cristalina apresentou variações em função da composição dos polímeros nas blendas e as transições térmicas não foram alteradas pelo extensor de cadeia. Análises de termogravimetria (TGA) mostraram o efeito de aumento na estabilidade térmica gerada pelo extensor de cadeia e o aumento da degradação térmica no processamento por injeção. A espectroscopia do infravermelho (FTIR) mostrou que grupos epóxido podem ter reagido com carboxilas e hidroxilas dos polímeros. A cromatografia por permeação em gel (GPC) mostrou que o extensor de cadeia promoveu aumento na massa molar do PLA, mas não apresentou o mesmo efeito no PBAT. Pela microscopia eletrônica de varredura (SEM), observou-se a presença de duas fases distintas. O extensor de cadeia promoveu a diminuição significativa no tamanho dos domínios da fase dispersa. Ensaios de resistência à tração mostraram que o PBAT aumentou a flexibilidade do PLA. Testes de resistência ao impacto mostraram aumento na resistência mecânica do PLA pela incorporação do PBAT. O extensor de cadeia reduziu a flexibilidade do PLA puro, mas aumentou a flexibilidade e a resistência mecânica nas blendas PLA/PBAT. Palavras-chave: Blendas poliméricas, plástico biodegradável, poli(ácido lático), aditivos
Abstract: Poly (latic acid) (PLA) is an attractive biodegradable polymer for industrial and medical applications. Although, some PLA properties like brittleness at room temperature restrict its potential applications and limit its full degradation only for composting conditions. The purpose of this work is to promote modifications in PLA properties by blending it with other biodegradable polymer, Poly (butylene-adipate-co-terephtalate) (PBAT). Joncryl ADR-4368, a multifunctional chain extender with epoxy functional groups was also used to increase polymers compatibility. Two processing methods were adopted: the samples in different compositions were processed in Drais homogenizer and torque reometer. Polymers and blends were processed with and without the chain extender. Differential Scanning Calorimetry (DSC) showed that the glass transition temperature (Tg) of the polymers did not change, which reveals immiscibility between PLA and PBAT. The behavior of the crystalline fraction exhibited variations depending on the composition of the blends and thermal transitions were not changed by chain extender. Thermo gravimetric analysis (TGA) showed that the chain extender caused an increase on thermal stability, and an increase of thermal degradation caused by injection molding processing. Infrared spectroscopy (FTIR) indicated that epoxy groups may be reacted with carboxyl and hydroxyl polymers functional groups. Gel permeation chromatograph (GPC) revealed that chain extender promoted molecular weight increasing in PLA but did not have the same effect on PBAT. Using Scanning electron microscopy (SEM) two phases morphology was detected. Chain extender promoted remarkable domains size reduction of the dispersed phase. Tensile strength tests demonstrated that PBAT enhanced flexibility and reduced brittleness of PLA. Impact strength tests showed an increment on PLA strength due to the presence of the PBAT. Chain extender reduced flexibility of PLA but also increased flexibility and tensile strength in PLA/PBAT blends. Keywords: polymer blends, biodegradable plastic, poly (latic acid), additives
Mestrado
Ciencia e Tecnologia de Materiais
Mestra em Engenharia Química
Pozza, Junior Mario Cezar. "Caracterização e aplicação de fibras obtidas por eletrofiação de PLA/PBAT com grafite incorporado." Universidade Estadual do Oeste do Paraná, 2018. http://tede.unioeste.br/handle/tede/3765.
Повний текст джерелаMade available in DSpace on 2018-06-15T23:20:03Z (GMT). No. of bitstreams: 1 Mario_Pozza_Junior_2018.pdf: 2690359 bytes, checksum: 4ed77b14d4ddbed87c7173f8cce14179 (MD5) Previous issue date: 2018-03-23
Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
The need for new tools to detect pollutants and of importance in the subject, electrochemical sensors are shown as a great alternative, considering its low cost, good limits of detection, and speed of analysis. An electro-spinning technique is a small fiber production technique where many possibilities for a sensor construction are offered, mainly using biodegradable polymers. This work has the objective of incorporating polymeric fibers with graphite optimized by an electrochemical technique, as well as an electrochemical sensor capable of obtaining a detection limit for the 2,4,6-trichlorophenol compound. A total of 35 experiments were carried out, using five different electrophilic techniques (needle distance to the collector, flow, tension, % of polymers, and % of graphite), as fibers as morphologically characterized using optical microscopy, SEM and a test of Wettability. For physical e structural analyzes, DSC, TGA and FTIR analyzes were performed, where it was sought to know if the incorporation of graphite into the polymer is capable of altering its structure. Then, for a sensor construction, a membrane obtained by electrospinning was then subjected to a heat treatment of 500°C for 3 hours, the powder obtained was mixed with the Nujol® wetting agent, thereby forming a uniform paste which was inserted into the End of a hypodermic plastic syringe with a silver wire for electrical contact, being manually pressed. The electrode was subjected to a characterization and an evaluation where a limit of detection was established for compound 2,4,6-TCP, in addition to a test with real samples collected in water treatment station supply. The minimum diameter obtained in the fibers was 1.49μm, using where the stress and voltage flows interacted, showing the effect of the second most significant order among all. As it analyzes morphologically revealed that a graphite incorporation has given the polymer membrane new characteristics to the surface, while as thermal analyzes show what is graphite changing a structure of the fibers when incorporated as its own. The only oxidation pic viewed with the Cyclic Voltammetry analysis characterizated the sensor containing a irreversible behavior face to 2,4,6-TCP. Based on the Square Wave Voltammetry analyzes, was obtained a detection limit for the 2,4,6-TCP of 1x10-7 mol.L-1 and showed a detection of the concentration test of 6x10-7 mol.L-1, with recovery rates of water samples between 80 and 93%, both in accordance with current Brazilian legislation.
A necessidade de novas ferramentas para detecção de poluentes é de suma importância atualmente, neste quesito, sensores eletroquímicos se mostram como uma ótima alternativa, tendo em vista seu baixo custo, bons limites de detecção, e rapidez na análise. A eletrofiação é uma técnica de produção de fibras em pequenas escalas onde muitas possiblidades para a construção de sensores são ofertadas, principalmente utilizando polímeros biodegradáveis. Este trabalho tem por objetivo obter fibras poliméricas incorporadas com grafite de forma otimizada pela técnica de eletrofiação, além de desenvolver um sensor eletroquímico capaz de obter um limite de detecção para o composto 2,4,6-Triclorofenol. Foram realizados 35 ensaios utilizando cinco diferentes parâmetros para eletrofiação (Distância da agulha ao coletor, fluxo, tensão, % de polímeros, e % de grafite), as fibras foram caracterizadas morfologicamente utilizando microscópio óptico, MEV, e um teste de molhabilidade. Para as análises físicas e estruturais, foram realizadas analises de DSC, TGA e FTIR, onde buscou-se saber se a incorporação de grafite ao polímero foi capaz de alterar sua estrutura. Depois, para a construção do sensor, a membrana obtida por eletrofiação foi então submetida a um tratamento térmico de 500°C por 3 horas, e o pó obtido foi misturado ao agente umectante Nujol®, formando assim uma pasta uniforme que foi inserida no interior da extremidade de uma seringa plástica hipodérmica com um fio de prata para o contato elétrico, sendo prensada manualmente. O eletrodo foi submetido a uma avaliação onde estabeleceu-se uma caracterização e um limite de detecção para o composto 2,4,6-TCP, além de um teste com amostras reais coletadas em estação de tratamento de águas de abastecimento. O Diâmetro mínimo obtido nas fibras foi de 1.49μm onde os parâmetros fluxo e tensão interagiram apresentando o efeito de segunda ordem mais significativo entre todos. As analises morfológicas revelaram que a incorporação de grafite concedeu a membrana polimérica novas características a superfície, enquanto que as análises térmicas mostraram que o grafite alterou a estrutura das fibras quando incorporado as mesmas. Ao obter apenas um pico de oxidação com a análise de voltametria cíclica o sensor apresentou um comportamento irreversível frente ao 2,4,6-TCP. Já com base nas análises de voltametria de onda quadrada obteve-se com o sensor um limite de detecção para 2,4,6-TCP de 1x10-7 mol.L-1 e o teste com águas de abastecimento detectou a concentração de 6x10-7 mol.L-1, com taxas de recuperação das amostras de água tratada entre 80 e 93%, ambas em concordância com a legislação brasileira vigente.
Oliveira, Marcelo Ferreira Leão de. "Preparação, caracterização e avaliação de nanocompósitos de PBAT/amido de milho e vermiculita organofilizada." Universidade do Estado do Rio de Janeiro, 2015. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9360.
Повний текст джерелаNos últimos 20-30 anos polímeros biodegradáveis vêm sendo estudados e desenvolvidos e atualmente já são comercializados. Contudo, o custo, a processabilidade e algumas propriedades ainda dificultam a penetração desses polímeros no mercado e a competição com as chamadas commodities. Não são poucos os autores que se dedicam a desenvolver aditivos e formulações para superar essas limitações. Desta forma, esta Tese se dedicou ao desenvolvimento de compósitos de Ecobras, fabricado pela Basf e comercializado pela Corn Products, utilizando como carga mineral resíduo da extração da bauxita, no município de Santa Luzia/PB, o qual consiste em sua totalidade de vermiculita. Esta vermiculita foi quimicamente modificada com sais de alquil fosfônio para melhorar a compatibilidade com a matriz polimérica e também espaçar as camadas de aluminossilicato. De fato, a modificação com o brometo de hexadecil tributil fosfônio resultou na esfoliação da vermiculita tornando-a potencialmente apropriada para a obtenção de nanocompósitos. A preparação dos compósitos foi realizada pelo método de intercalação no estado fundido e foram comparadas a utilização da câmara interna de mistura e da mini extrusora de dupla rosca, sendo esta última mais eficaz na dispersão da vermiculita, conforme revelado pela microscopia eletrônica de varredura, difração de raios-X e reometria de placas. O grau de dispersão também foi influenciado pela estrutura química do modificador da vermiculita e pelo teor dessa carga incorporada à matriz. Teores mais elevados levaram a formação de aglomerados, enquanto a modificação da carga implicou na formação de micro e nanocompósitos. Ainda houve alterações das propriedades térmicas com aumento dos valores da temperatura de transição vítrea, de cristalização e fusão, embora o grau de cristalinidade tenha sido mantido. Nitidamente, foram obtidos materiais mais rígidos, com maior módulo e menor capacidade de deformação. Cerca de 58% de perda de massa foi observada para os micro e nanocompósitos obtidos após 17 semanas de enterro em solo simulado para avaliação da biodegradabilidade, valor bem próximo ao Ecobras puro. De modo geral, a incorporação das diferentes vermiculitas retardou nas primeiras semanas a biodegradação, provavelmente em função de modificações na estrutura cristalina, conforme sugerido pelos maiores valores de temperatura de fusão observados durante o acompanhamento do processo de biodegradação. No entanto, após 7 semanas os perfis de biodegradação dos micro e nanocompósitos se aproximaram bastante do Ecobras puro. Desta forma, foi possível nesta Tese obter um nanocompósito de Ecobras com vermiculita modificada com brometo de hexadecil fosfônio utilizando ferramentas comuns de processamento no estado fundido com biodegradabilidade próxima ao polímero de partida, porém mais rígido e menos deformável
In the last 20-30 years biodegradable polymers have been studied and developed and currently are already commercialized. However, cost, processability and some properties still avoid the penetration of such polymers on the market and the competition with the so-called commodity. There are few authors who are dedicated to developing additives and formulations to overcome these limitations. Thus, this thesis is devoted to the development of Ecobras composites, blend of PBAT and starch manufactured by BASF and commercialized by Corn Products, using as mineral filler a residue of bauxite extraction from Santa Luzia / PB, which consists entirely of vermiculite. The vermiculite was chemically modified with alkyl phosphonium salts to improve compatibility with the polymer matrix, and also to increase the space between aluminosilicate layers. In fact, its modification with hexadecyl tributyl phosphonium bromide promoted the exfoliation of vermiculite making it potentially suitable for obtaining a nanocomposite. The preparation of the composites was performed by the melt intercalation technique. Internal mixing chamber and a twin screw mini-extruder were compared as processing tool, the latter was more effective in dispersing the vermiculite, as revealed by scanning electron microscopy, X-ray diffraction and plate rheometry. The degree of dispersion was also influenced by the amount and chemical structure of the vermiculite. Higher filler levels led to formation of agglomerates, while filler modification led to formation of micro and nanocomposites. There were changes in the thermal properties with increasing temperature values of glass transition, crystallization and melting, although the degree of crystallinity has been retained. Clearly, stiffer materials were obtained, with a higher modulus and low strain capacity. About 58% of weight loss was observed for micro and nanocomposites after 17 weeks of burial in simulated soil for evaluation of biodegradability, very close to pure Ecobras value. Generally, the incorporation of different vermiculite delayed biodegradation in the first weeks, probably due to changes in crystalline structure as suggested by the higher melting temperature values observed during the monitoring of the biodegradation process. However, after seven weeks of the micro and nanocomposites biodegradation profiles approached quite to pure Ecobras. Thus, it was possible in this work obtain a Ecobras nanocomposite with hexadecyl tetrabutyl phosphonium bromide modified vermiculite prepared by melt intercalation technique using common processing tools and with biodegradability close the starting polymer, but more rigid and less deformable
Nossa, Tamires de Souza. "Novas composições poliméricas obtidas a partir da modificação do amido via extrusão reativa." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/18/18158/tde-09012015-104750/.
Повний текст джерелаThermoplastic starch (TPS) is a biodegradable material, inexpensive, with high potential of usage in the biodegradable plastics composition. Many studies have been performed to improve some properties, mainly its low mechanical strength, high hydrophilicity and low miscibility with commercial polymers, factors that hinder the usage expansion such material as plastic. An alternative to improve these properties is the polymer blends of starch production with other polymers. However, when the materials chemical nature is quite variable then is necessary to make the polymers compatible. Usually, the reactive compatibility is obtained by the addition of coupling agents or promoting reactions during extrusion. In the present study, new alternatives were studied in order to increase the starch application potential including: the citric acid effect on starch modification; use of urea to stabilize the starch molecular weight by reactive extrusion allowing its reprocessing; the starch modification with citric acid and 4,4\'-diphenyl methane diisocyanate and the use of two reactive extrusion processes for thermoplastic starch producing; starch blends production with poly (butylene adipate co-terephthalate) and poly (lactic acid); the starch modification by incorporating crosslinking thermoreversible Diels-Alder adduct. Several characterizations were made including thermal analysis by means of thermogravimetry (TGA), differential scanning calorimetry (DSC), dynamical mechanical analysis (DMA) mechanical testing, moisture absorption, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), rheology analysis, chromatography (HPSEC) and viscometry. The research results have contributed to the development of new thermoplastic polymers or thermosetting from corn starch and helped to clarify issues not addressed in the literature about the starch modification by reactive extrusion process.
Lu, Daoqiang. "Synthesis and characterization of a star-like poly(p-Benzamide) (PBA)." Thesis, Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/8604.
Повний текст джерелаSchmiech, Peter [Verfasser]. "Zur Vorhersage des Kristallhabitus unter Fremdstoffeinfluss mittels PBC-Vektoren / Peter Schmiech." Aachen : Shaker, 2005. http://d-nb.info/1181614430/34.
Повний текст джерелаPopayán, Avila Jhossep Augusto. "Contributions to ida-pbc with adaptive control for underactuated mechanical systems." Master's thesis, Pontificia Universidad Católica del Perú, 2018. http://tesis.pucp.edu.pe/repositorio/handle/123456789/12894.
Повний текст джерелаTesis
Vidal, Sandoval Jesus Enrique. "Implicit IDA-PBC Design and Implementation for a Portal Crane System." Master's thesis, Pontificia Universidad Católica del Perú, 2019. http://hdl.handle.net/20.500.12404/15353.
Повний текст джерелаInterconnection and damping assignment passivity-based control (IDA-PBC) ist eine wohlbekannte Methode zur Regelung von nichtlinearen Systemen, die im geschlossenen Regelkreis eine gewünschte Port-Hamiltonian-Struktur (pH) haben. Die Anwendung auf unteraktuierte mechanische Systeme (UMS) erfordert die Erfüllung von sogenannten Matching Conditions, die meistens die Lösung partieller Differentialgleichungen (PDE) benötigt. Erst kürzlich wurde die IDA-PBC auf implizit modellierte UMS erweitert, bei denen die Systemdynamik in pH-Darstellungen durch Differentialalgebraische Gleichungen (DAE) beschrieben wird. Dieser implizite Ansatz ermöglicht bei einigen Systemklassen, das PDE-Problem zu umgehen und auch eine Ausgangsrückführung zu entwerfen. Die vorliegende Masterarbeit beschäftigt sich mit dem Entwurf und der Implementierung des impliziten IDA-PBC zur Gesamtenergievorgabe auf einem Portalkransystem im Labor des Fachgebiets Regelungstechnik der TU-Ilmenau. Der implizite Regler wird mit einem vereinfachten (expliziten) IDA-PBC verglichen [1]. Dieser Algorithmus gibt ebenso die Gesamtenergie vor und vermeidet das PDE-Problem. In der Masterarbeit wird in diesem Algorithmus ein wesentlicher Implementierungsfehler offengelegt und behoben.
Tesis
Cron, Mélanie. "Implication of microRNAs in the pathophysiology of autoimmune Myasthenia Gravis Analysis of microRNA expression in the thymus of Myasthenia Gravis patients opens new research avenues Use of Toll-like receptor agonists to induce ectopic lymphoid structures in Myasthenia gravis Mouse Models." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS395.
Повний текст джерелаAutoimmune Myasthenia Gravis (MG), characterized by autoantibodies directed against the acetylcholine receptor at the neuromuscular junction, is a rare disease causing muscular weaknesses. This study shows the involvement of small non coding RNAs, miRNAs, in the pathophysiology of MG. We investigated the expression of dysregulated miRNAs in the effector organ of the disease, the thymus, through a miRnome analysis. I showed 1) that miR-7-5p could participate in thymic abnormalities observed in patients through its action on CCL21, 2) the down-regulation of two miRNA clusters on chromosome X and, 3) a new MG inflammatory pathway involving miR-125a-5p and WDR1. I also studied the sensitivity of miR-29a KO mice to the experimental model of MG. Indeed, miR-29a is down-regulated in MG thymuses and modulates type 1 interferon pathway, involved in thymic changes. Finally, I investigated the causes and consequences of the serum overexpression of miR-150-5p, characterized as a biomarker in MG. We showed that miR-150 is overexpressed in MG thymuses and correlated to the presence of ectopic germinal centers. Moreover, miR-150 is down-regulated in CD4+T cells, in the blood of patients. Once in the serum, miR-150 modulated the expression of target genes, such as MYB, and is involved in the survival of CD4+ and CD8+ T cells. These studies allows a better understanding of how miRNAs are involved in the pathophysiology of MG and allowed us to open new research avenues in MG
Siddique, Manazzar T. "Interactions of caboxylated acrylic polymer latex particles with hydrating portland cement materials." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297921.
Повний текст джерелаGupta, Priyanka. "Host gene expression and its regulation by microRNA in HCV and HIV/HCV co-infection." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/11998.
Повний текст джерелаAGOSTINI, L. P. "AMENDMENT Of Gene Expression In Mononuclear Cells Of Human Peripheral Blood Submitted To Exposure With Herbicide Based On Glyphosate." Universidade Federal do Espírito Santo, 2018. http://repositorio.ufes.br/handle/10/10333.
Повний текст джерелаO Glifosato [N-(fosfonometil)glicina] é um herbicida pós-emergente, não seletivo e sistêmico. No processo de criação das formulações comerciais de herbicidas a base de glifosato (GBHs, do inglês glyphosate-based herbicides), como o Roundup®, são adicionados surfactantes com o intuito de aumentar a eficiência do composto base. A rota prioritária de degradação do glifosato por micro-organismos no solo resulta na formação do ácido aminometilfosfônico (AMPA). As respostas moleculares ao glifosato têm sido extensivamente estudadas em espécies de plantas e em alguns vertebrados. Em humanos, apesar dos estudos até agora realizados, não se conhece exatamente quais os riscos e mecanismos de atuação que explicariam a toxicidade ao glifosato relatada em alguns experimentos. Sendo assim, a hipótese dessa tese é de que a exposição rápida ao Roundup® e ao AMPA leva à alterações de expressão gênica em importantes processos celulares. Dessa forma, o objetivo desse trabalho é identificar genes diferencialmente expressos (DEGs, do inglês differentially expressed genes) em células mononucleares do sangue periférico (PBMCs, do inglês, peripheral blood mononuclear cells) humano submetidas à exposição rápida com herbicida à base de glifosato (Roundup®) e AMPA. O teste de MTT [3(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazólio brometo], realizado em triplicatas, foi utilizado para avaliar a viabilidade celular e para a escolha das condições de tratamento utilizadas na técnica de microarray (GeneChip® Human Transcriptome Array 2.0, Affymetrix). As condições analisadas foram controle (3 chips), AMPA (10 mM; 3 chips) e Roundup® (0,05%; 2 chips), expostos durante 3 horas. Utilizando um valor de p<0,05 e fold-change de 1,5 foram identificados 5 DEGs no tratamento com o AMPA e 26 no tratamento com Roundup®. As análises de enriquecimento mostraram que os genes com expressão alterada após exposição ao Roundup® estavam associados a 33 processos celulares, principalmente relacionados à regulação destes processos. A plataforma digital Pathview foi utilizada para identificar a atuação dos DEGs após exposição ao Roundup® em diferentes vias. Os genes TNF, LTA, TAB2 e ATM foram relacionados à via de sinalização NF-kappa β; BCL2L11 e ATM à via de sinalização FoxO; SESN3 e ATM à via de sinalização p53; e TNF, BCL2L11 e ATM à apoptose. Dessa forma, os resultados sugerem que o Roundup® altera o padrão de expressão gênica de diversos genes associados com o controle do ciclo celular, regulação de processos celulares e apoptose.
Deng, Yixin. "Optimising properties of poly(lactic acid) blends through co-continuous phase morphology." Thesis, Loughborough University, 2017. https://dspace.lboro.ac.uk/2134/33338.
Повний текст джерелаUhl, Juli D. "Hox Specificity: Constrained vs. Flexible Requirements for the PBC and MEIS Cofactors." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397234792.
Повний текст джерелаFrantz, Markus. "Dehydroepiandrosteron (DHEA): Ein Steroidhormon mit immunmodulatorischem Potential im Hinblick auf die PBMC-Funktion abdominal-chirurgischer Patienten." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-39353.
Повний текст джерелаZannini, Chiara <1988>. "Studio dell'effetto immunomodulatorio in vitro di NGAL su PBMC di pazienti in trattamento emodialitico e iperimmuni." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8282/1/Chiara%20Zannini_PhD%20thesis.pdf.
Повний текст джерелаIn recent years, an increasing number of patients waiting for a kidney transplant showed the presence of alloantibodies against HLA antigens and non-HLA. Evidence demonstrates the contribution of regulatory T lymphocyte cells (Treg) in modulating the immune response in different animal models and in clinical transplant, to suggest their potential use as markers of tolerance, rejection or prediction of organ transplant outcome. Recently, Treg has been shown to increase immunotolerance following MSCs infusion into experimental models of solid organ transplantation. We have previously provided in vitro evidence that NGAL (Neutrophil gelatinase-associated lipocalin), a known biomarker of renal injury, is able to induce immune tolerance by upregulating HLA-G expression and expansion of Treg in normal subjects. In this study, we evaluated the effect of NGAL on the expansion of Treg and HLA-G expression in haemodialysis and hyperimmunized patients; then, we investigated the immunomodulatory effect of adipose-derived mesenchymal stem cells (ASCs) on PBMCs derived from patients. We carried out isolation from peripheral blood mononuclear cells (PBMCs) and immunophenotypic in vitro characterization of Treg after NGAL treatment and after co-culture with ASCs. Our results demonstrated an immunomodulatory effect NGAL-mediated on lymphomonocyte population derived by non-hyperimmunized, as Treg population and HLA-G expression augmented, while this effect is inhibited in PBMCs derived from hyperimmunized patients. The immunomodulatory effect on PBMCs in these patients is re-established in vitro by co-culture with adipose-derived mesenchymal stem cells. ASCs could be a good future possibility for modulating immune system before or during kidney transplant in hyperimmunized patients, expanding access to transplants to these complex patients.
Su, Shiwei. "Effectiveness of central bank communication on financial markets in emerging economies, with a special focus on China." Thesis, Loughborough University, 2018. https://dspace.lboro.ac.uk/2134/33386.
Повний текст джерелаDunn, Andrew W. "Cationic Nanoparticles for the Targeting and Delivery of Nucleic Acids to the Pulmonary Endothelium." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1544098242321181.
Повний текст джерелаKohrs, Nicholas John. "SYNTHESIS AND CHARACTERIZATION OF BLUE LIGHT POLY(β-AMINO ESTER)S". UKnowledge, 2018. https://uknowledge.uky.edu/cbme_etds/53.
Повний текст джерелаSilva, Lorena Christine Ferreira da. "Interação de acanthamoeba polyphaga mimivirus com o sistema interferon humano em células mononucleares do sangue periférico (PBMC)." Universidade Federal de Minas Gerais, 2013. http://hdl.handle.net/1843/BUBD-9UKJ3B.
Повний текст джерелаAcanthamoeba polyphaga mimivirus (APMV) é um vírus gigante de DNA, descoberto em 2003, pertencente a família Mimiviridae e que apresenta elevada complexidade estrutural e genômica. Embora amebas de vida livre sejam consideradas hospedeiros de APMV, estudos recentes têm demonstrado que o vírus é capaz de multiplicar em fagócitos e acredita-se que pode ser um agente patogênico causador de pneumonia em humanos. No presente estudo, foi investigado como alguns componentes do sistema interferon humano são estimulados por APMV em células mononucleares do sangue periférico (PBMC) e como a multiplicação do vírus é afetada pelo tratamento com IFN do tipo I. Os resultados demonstraram que APMV é capaz de se replicar em PBMC humanas totais, induzindo IFN do tipo I nestas células, mas inibindo genes estimulados por IFN (ISG) por um mecanismo independente da presença de viroceptores e desfosforilação de STAT. Foi visto também que APMV é resistente à ação antiviral do IFN alfa2 (IFNA2) mas é sensível à ação antiviral de IFN beta (IFNB1). Os resultados obtidos confirmam estudos anteriores, os quais demonstraram que há infecção produtiva de fagócitos profissionais com APMV, e mais, mostram que este vírus é reconhecido pelo sistema imunitário dos vertebrados e é capaz de inibí-lo. Assim, foram fornecidos os primeiros dados sobre interação do sistema IFN e APMV e levantadas novas questões evolutivas e relevantes sobre a relação entre APMV e hospedeiros vertebrados.
Mells, George Frank Gannaway. "Investigation of the genetic basis of primary biliary cirrhosis : the PBC genetics study." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648610.
Повний текст джерелаFoos, Nicolas. "Etudes structurales d'un complexe HOX-PBC de drosophile. : Un exemple de régulateur transcriptionnel." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4075.
Повний текст джерелаHox proteins are homeodomain proteins belonging to the Transcription Factors superfamilly. These proteins are necessary for the determination of the cellular identity along the anteroposterior, dorsoventral and proximodistal axes. It's essential to recognize DNA targets with high specificity. One possible mechanism to acquire specificity implies the cooperativity between Hox and their PBC partners. Ubx (Hox) and Exd (PBC) proteins from D. melanogaster are the object of this work. One mechanisme of coopertivity involves the “hexapeptide” motif in Ubx and another one that involves its UbdA motif. The UbdA motif is located C-terminal to the recognition helix. We have solved seven different structures of Ubx-Exd-DNA complexes. Thanks to these structures, we show that UbdA can have a multipurpose role : it can provide an interaction surface to contact Exd and it can also act like a hinge between the C-terminal regions of Ubx and its homeodomain. UbdA and HX motifs from Ubx are not the only regions involved in the control of these proteins functions. Ubx and Exd also contain intrinsically disordered regions which are the linker region and the homeodomain N-terminal arm, for Ubx and Exd respectively. They interact with the DNA in the minor groove and can explore the space around. We studied the Exd 's C-terminal motif and determined that it has a flexible, helical fold. The folding of this fourth helix could modify the contacts established with Ubx and with the DNA. All these observations allow us to add supplementary information for the understanding of functional specificity and provide new arguments for the monkey-bar and for the « gliding interface » DNA- scanning models
Escudero, Astudillo Paulino Alberto. "Diseño de un silo dosificador para pasta de baterías." Tesis, Universidad de Chile, 2016. http://repositorio.uchile.cl/handle/2250/143614.
Повний текст джерелаEl trabajo muestra el diseño de un silo para el acopio y dosificación de pasta de baterías (PBat), para la línea productiva de una planta industrial y fundición; que se dedica al reciclaje de baterías de plomo-ácido para la obtención de plomo refinado. El objetivo del trabajo es el diseño de un silo para el acopio y dosificación de PBat integrado en una línea de manejo y dosificación de materiales. Los objetivos específicos son: i) Revisar el es-tado del arte sobre silos para acopio y dosificación de pastas, ii) Caracterizar la PBat y determinar las condiciones de operación del silo inserto en la línea de producción, iii) Diseñar los mecanismos de extracción de la PBat, iv) Seleccionar y diseñar detalladamente una motorización ad hoc para el silo, y v) Diseñar una lógica de control que permita integrar el silo de PBat con la tecnología Weightfeeders de la línea de manejo y dosificación de materiales. Para desarrollar los objetivos específicos se emplea una metodología que integra revisión biblio-gráfica del estado del arte de silos y dosificación de pasta para obtener el marco teórico para el diseño de los componentes principales; revisión de normas internacionales ASTM para diseñar y validar técnicamente los ensayos de caracterización de la PBat. Para el diseño detallado se em-plean los resultados de los ensayos y los requerimientos de operación a partir de los que se realiza el dimensionamiento y la configuración de los mecanismos de descarga y dosificación junto con la motorización de ellos. Para abordar el sistema de control se define la filosofía de control, los sensores y los lazos de control. Los principales resultados del trabajo muestran que: i. La tecnología para silos de pasta se centra en los sistemas de descarga. Los sistemas más im-portantes en la actualidad son descarga mecánica por: movimiento alternativo, ejes encontra-dos, descargador de tornillo y descargador rotatorio. ii. La pasta de baterías es un material reologicamente complejo con facilidad para formar bóvedas con un ángulo de reposo alto, una granulometría heterogénea y un esfuerzo de cizalle rela-tivamente alto de 0,6 kg/cm2. iii. El silo, un estanque cilíndrico-cónico de 4,5 m3 en AISI 316L, contempla dos sistemas de des-carga complementarios: un descargador rotatorio que arrastra la pasta por el fondo del silo sin compactarla descargando el material por una lumbrera y un sistema de arrastre vertical; que destruye las bóvedas al forzar el avance de la pasta hacia el fondo del silo. iv. La lógica de control integra los distintos equipos que forman la línea de manejo de materiales plomados. En particular la integración con los weightfeeder está diseñada lograr la dosificación precisa de los materiales involucrados en la línea de proceso.
Kam, Siu-kei Christy. "The role of TGF-[beta] signaling in the initiation of TNF-[beta] expression in human PBMC derived macrophages." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38746049.
Повний текст джерелаKam, Siu-kei Christy, та 甘笑琪. "The role of TGF-{221} signaling in the initiation of TNF-α expression in human PBMC derived macrophages". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38746049.
Повний текст джерелаChuck, Lisa. "A PREDICTIVE MODEL FOR BENCHMARKING ACADEMIC PROGRAMS (PBAP)USING U.S. NEWS RANKING DATA FOR ENGINEERING COLLEGES OFFERING GRADU." Doctoral diss., University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2397.
Повний текст джерелаEd.D.
Department of Educational Research, Technology and Leadership
Education
Educational Leadership
ABANS, Mariângela de Oliveira. "Parametrização de redes neurais artificiais em problemas de séries temporais não lineares empregando PBCA (Plackett-burman correlation analysis)." reponame:Repositório Institucional da UNIFEI, 2018. http://repositorio.unifei.edu.br/xmlui/handle/123456789/1429.
Повний текст джерелаMade available in DSpace on 2018-06-29T17:53:27Z (GMT). No. of bitstreams: 1 tese_2018016.pdf: 7348957 bytes, checksum: 39237c89c95bdb2055e4b91fe2b855c3 (MD5) Previous issue date: 2018-04-20
Séries temporais são encontradas em fenômenos naturais, mercadológicos e financeiros, e em processos de manufatura, entre outros, o que as torna importantes objetos de pesquisa. Quando não são lineares, sua modelagem é complexa devido ao grande número de parâmetros, à existência de fatores exógenos, à alta volatilidade e à presença de sazonalidade. Tem sido demonstrado que, nesses casos, RNAs apresentam bom desempenho tanto na apreensão do comportamento dos dados como na sua previsão dentro dos limites de exatidão requeridos. Apesar do grande número de parâmetros de uma RNA, delineamentos têm sido usados com sucesso, porém a alta demanda de recursos humanos, computacionais, financeiros e de tempo são obstáculos para sua total exploração. Neste trabalho, implantou-se uma nova metodologia denominada Análise de Correlação em Plackett_Burman (Plackett_Burman Correlation Analysis ̶ PBCA) na parametrização de Redes Neurais Artificiais ̶ RNAs, com o propósito de modelar e prever Séries Temporais Univariadas Não Lineares. Esta é uma metodologia de seleção de variáveis significativas baseada no Delineamento de Experimentos (DOE) de Plackett_Burman com rebatimento e que propõe a análise de correlação entre as séries de resíduos, consideradas como sinais. Sua vantagem é requerer um número de experimentos menor que o Delineamento Fatorial Completo e ser capaz de identificar as significativas interações de segunda ordem entre todas as variáveis. Nesta tese, implementou-se esta nova metodologia PBCA na construção de RNAs previsoras para auxiliar os profissionais responsáveis por decisões tático-estratégicas baseadas em séries temporais. A metodologia foi aplicada a dois casos: (i) número de horas disponíveis para pesquisa em um observatório astronômico profissional de classe mundial e (ii) distribuição de carga elétrica fornecida a uma empresa brasileira, com o objetivo de fornecer previsões de curtíssimo e curto prazos para a tomada de decisões sobre o melhor uso das infraestruturas envolvidas. Ambas as séries foram primeiramente estudadas através da aplicação de técnicas e modelos ditos “clássicos” a fim de estabelecer benchmarking para comparação. Os resultados deste trabalho sugerem a adequação apenas parcial da metodologia para estes fins. Não é possível aplicar a PBCA totalmente devido (i) à maneira de definir as RNAs, (ii) ao fato do processo não ser modelável, afinal e (iii) à impossibilidade de uso das interações de ordem dois entre as variáveis significativas no software Statistica®. São também apresentados possíveis desdobramentos da pesquisa e aplicações em outras áreas do conhecimento.
Hammack, Lindsay Jo. "Identification of the Pba1 and Pba2 Binding Sites on 20S Core Particle Intermediates." 2013. http://hdl.handle.net/1805/3362.
Повний текст джерелаThe proteasome is responsible for breaking down the majority of the proteins in the cell. However, a complete understanding of how this large multi-subunit protease is assembled is currently lacking. Proper and timely assembly of the proteasome is critical for the functioning of the ubiquitin-proteasome pathway, defects in which have been associated with several different cancers. A recently discovered heterodimeric proteasome assembly chaperone, Pba1p-Pba2p, has been suggested to prevent the assembly process from straying off path. Pba1p-Pba2p associates with proteasomal assembly intermediates via C-terminal HbYX motifs. The HbYX motif is a tri-peptide sequence containing a hydrophobic residue (Hb) followed by a tyrosine (Y), then any amino acid (X). This motif was originally identified in proteasomal activators, and shown to mediate the association of activators with the proteasome by inserting into intersubunit pockets on either end of the proteasome. There are seven unique intersubunit binding pockets, located between neighboring α subunits on the proteasome, to which a HbYX-containing protein can bind; which of these pockets Pba1p-Pba2p binds to remains elusive. I attempted to identify where Pba1p and Pba2p bind via a crosslinking approach. Specific residues were mutagenized to cysteines on Pba1p, Pba2p, and the individual α subunits in order to generate crosslinkable species. By exposing yeast cells expressing these crosslinkable proteins to mild oxidizing conditions, I attempted to trap the Pba1p and Pba2p α intersubunit pocket interactions. In order to optimize crosslinking conditions, the assay was modified several ways. Additionally, measures were taken to increase detection of the crosslinked species via immunoblotting. Despite the efforts to improve the crosslinking and detection, I was unable to successfully detect a crosslinked species. However, crosslinking is a reasonable method to identify the Pba1p and Pba2p proteasomal binding sites, having been successfully used to identify binding sites for other HbYX-motif-containing proteins; further assay optimization should yield Pba1p and Pba2p proteasomal crosslinks.
Liao, Hsiang-Chou, and 廖翔舟. "PBAT/MA crosslink films physical and to confer PBAT biodegradable conditions." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/30349848572644601507.
Повний текст джерела國立臺灣科技大學
高分子系
96
First part of this dissertation is to study the crosslink reaction between PBAT and MA in order to apply to the study of the biodegradable membrane by analyzing the physical property, chemical property and biolysis of the membrane after adding different MA proportion o PBAT. Second part is to study the life cycle of Alcaligens faecalis and resolving condition of PBAT membrane by resolving the PBAT membrane (Poly (butylene adipate-co-terephthalate) by Alcaligens faecalis. Under NB medium environment, the amount of Alcaligens faecalis reaches the maximum germs after 11 hours of culture. And Under the mineral medium (MM) environment, 2.6% (the percentage of loss of weight) of PBAT is resolved in two weeks. As of the PBAT membrane after crosslink reaction with MA, -OH peak disappears (observed by IR); both stress and Yang's modulus increase (by tension test); the roughness is reduced (observed by AFM); the heat stability property of the material increase while Tm does not to rise (by TGA and DSC); the original crystallization structure of PBAT is invariant after the crosslink reaction of PBAT/MA (by SAXS). In general, after PBAT/MA crosslink reaction, the mechanical property of PBAT membrane is improved so that expand the application in the biodegradable environmental protection membrane.
Ke, Li Yuan, and 柯力元. "Measuring Magnetoresistance of PbAu Alloy at Low Temperatures." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/qn2y9d.
Повний текст джерела國立清華大學
物理系
105
Binary surface alloy made of heavy elements, Pb and Au, has exhibited strong Rashba effect in its band structure. To investigate its corresponding performance in electric transport, we first grew such a PbAu-alloy thin film, composed of the Pb film with PbAu alloy layer on the top, in the UHV chamber. After the sample of PbAu-alloy film was made, we took the sample out of UHV chamber and fabricate it into a Hall-bar device via lithography for low-temperature magneto-resistance measurement with the applied magnetic field parallel to the sample surface. Based on the experimental result, we could find that once the temperature dropped below transition temperature. ~ 6 K, of Pb, the spin-polarized charge current appeared in the transverse direction causing the observed abrupt increase of the voltage. Furthermore, we also observed that the oscillation of voltage as a function of applied magnetic field in the weak limits from 0.2 Tesla to 3.6 Tesla and the non-ohmic behavior in terms of the I-V relation. One can realize the appearance of spin-polarized charge current by considering the influence from Rashba effect, leading to spin Hall or anomalous Hall effect. Such spin -polarized charge current is closely related to superconductivity of Pb thin films; when the temperature goes below the transition temperature, the transport currents would concentrate on the Pb film so as to increase the probability of scattering to top PbAu alloy layer that has giant Rashba effect. Such strong spin-orbital interaction would not just lead to the diffusion of spin-polarized current in transverse direction but very likely breaking time-resolved symmetry via the change of superconducting state under Rashba interaction. When the temperature goes above transition temperature, spin polarized charge current is small, so the behavior becomes more Ohmic. Finally, the measured oscillation of voltage under the weak magnetic field could be realized by considering spin-magnetic moment of electrons in the spin-polarized charged currents exposed to the external magnetic field resulting in precession of spin magnetic moment.
Liu, Tien Sheng, and 劉天聲. "Characterization of PBAT/PEgMA Blends and Blend-based Nanocomposites." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/88937833257857119515.
Повний текст джерела